$681 Million is the total value of Opaleye Management Inc.'s 58 reported holdings in Q1 2021. The portfolio turnover from Q4 2020 to Q1 2021 was 52.5% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| OCUL | Sell | OCULAR THERAPEUTIX INC | $106,337,000 | -21.1% | 6,480,000 | -0.5% | 15.62% | -11.3% |
| CMRX | Buy | CHIMERIX INC | $43,284,000 | +126.5% | 4,490,000 | +13.5% | 6.36% | +154.7% |
| TARA | PROTARA THERAPEUTICS INC | $40,270,000 | -35.0% | 2,558,472 | 0.0% | 5.92% | -26.9% | |
| BBIO | New | BRIDGEBIO PHARMA INC | $35,960,000 | – | 583,767 | +100.0% | 5.28% | – |
| CDXS | CODEXIS INC | $32,046,000 | +4.9% | 1,400,000 | 0.0% | 4.71% | +17.9% | |
| ETON | ETON PHARMACEUTICALS INC | $29,573,000 | -10.0% | 4,040,000 | 0.0% | 4.34% | +1.3% | |
| MGNX | Buy | MACROGENICS INC | $21,218,000 | +150.4% | 666,200 | +79.8% | 3.12% | +181.6% |
| TCON | TRACON PHARMACEUTICALS INC | $20,726,000 | -29.7% | 2,518,371 | 0.0% | 3.04% | -20.9% | |
| HROW | HARROW HEALTH INC | $20,692,000 | -1.6% | 3,065,416 | 0.0% | 3.04% | +10.6% | |
| CLDX | Sell | CELLDEX THERAPEUTICS INC | $20,291,000 | +16.7% | 985,000 | -0.7% | 2.98% | +31.3% |
| XOMA | Sell | XOMA CORP DEL | $17,854,000 | -11.1% | 437,500 | -3.8% | 2.62% | -0.0% |
| STXS | Sell | STEREOTAXIS INC | $16,978,000 | +10.4% | 2,526,500 | -16.4% | 2.49% | +24.1% |
| NLTX | Sell | NEOLEUKIN THERAPEUTICS INC | $15,080,000 | -22.9% | 1,225,000 | -11.6% | 2.22% | -13.2% |
| FBIO | Sell | FORTRESS BIOTECH INC | $13,679,000 | +11.0% | 3,875,000 | -0.3% | 2.01% | +24.8% |
| CYTK | Sell | CYTOKINETICS INC | $13,491,000 | +11.4% | 580,000 | -0.5% | 1.98% | +25.3% |
| AUTL | New | AUTOLUS THERAPEUTICS PLCsponsored ads | $12,107,000 | – | 2,112,918 | +100.0% | 1.78% | – |
| GMTX | New | GEMINI THERAPEUTICS INC | $10,982,000 | – | 810,500 | +100.0% | 1.61% | – |
| DCPH | DECIPHERA PHARMACEUTICALS IN | $9,954,000 | -21.4% | 222,000 | 0.0% | 1.46% | -11.7% | |
| MCRB | Sell | SERES THERAPEUTICS | $9,804,000 | 0.0% | 300,000 | -10.5% | 1.44% | +12.4% |
| KROS | New | KEROS THERAPEUTICS INC | $9,694,000 | – | 157,500 | +100.0% | 1.42% | – |
| CKPT | New | CHECKPOINT THERAPEUTICS INC | $9,188,000 | – | 2,925,963 | +100.0% | 1.35% | – |
| PRQR | New | PROQR THERAPEUTICS NV | $8,613,000 | – | 1,303,000 | +100.0% | 1.26% | – |
| EPIX | ESSA PHARMA INC | $8,252,000 | +143.5% | 284,050 | 0.0% | 1.21% | +173.6% | |
| AFIB | Sell | ACUTUS MEDICAL INC | $8,222,000 | -61.9% | 614,990 | -18.0% | 1.21% | -57.2% |
| ADMS | Buy | ADAMAS PHARMACEUTICALS INC | $8,019,000 | +24.5% | 1,670,600 | +12.3% | 1.18% | +40.1% |
| CERC | Sell | CERECOR INC | $7,852,000 | +13.5% | 2,600,000 | -0.8% | 1.15% | +27.5% |
| STRO | Buy | SUTRO BIOPHARMA INC | $7,783,000 | +11.3% | 341,950 | +6.1% | 1.14% | +25.1% |
| PTGX | Buy | PROTAGONIST THERAPEUTICS INC | $7,692,000 | +9.6% | 297,000 | +14.2% | 1.13% | +23.2% |
| IMVT | New | IMMUNOVANT INC | $7,491,000 | – | 467,000 | +100.0% | 1.10% | – |
| PCVX | Buy | VAXCYTE INC | $7,067,000 | -20.6% | 357,800 | +6.7% | 1.04% | -10.7% |
| SMTI | New | SANARA MEDTECH INC | $7,009,000 | – | 225,000 | +100.0% | 1.03% | – |
| CBIO | Buy | CATALYST BIOSCIENCES INC | $6,300,000 | +570.9% | 1,250,000 | +740.1% | 0.92% | +652.0% |
| AVEO | Buy | AVEO BIOSCIENCES INC | $6,112,000 | +1702.9% | 835,000 | +1320.1% | 0.90% | +1940.9% |
| KNSA | Buy | KINIKSA PHARMACEUTICALS LTD | $5,940,000 | +50.0% | 320,926 | +43.2% | 0.87% | +68.7% |
| VSTM | VERASTEM INC | $5,743,000 | +20.6% | 2,325,000 | 0.0% | 0.84% | +35.7% | |
| TELA | TELA BIO INC | $5,439,000 | -0.9% | 365,000 | 0.0% | 0.80% | +11.4% | |
| MEIP | MEI PHARMA INC | $5,337,000 | +29.9% | 1,556,000 | 0.0% | 0.78% | +46.0% | |
| CRDF | Sell | CARDIFF ONCOLOGY INC | $5,334,000 | -82.2% | 576,000 | -65.4% | 0.78% | -80.0% |
| SIOX | SIO GENE THERAPIES INC | $5,220,000 | -6.1% | 2,000,000 | 0.0% | 0.77% | +5.6% | |
| Buy | APTOSE BIOSCIENCES INC | $5,209,000 | +48.7% | 871,800 | +9.0% | 0.76% | +67.0% | |
| MYOV | Sell | MYOVANT SCIENCES LTD | $5,141,000 | -51.0% | 249,800 | -63.4% | 0.76% | -44.9% |
| FGEN | FIBROGEN INC | $5,102,000 | -6.4% | 147,000 | 0.0% | 0.75% | +5.2% | |
| LUMO | Buy | LUMOS PHARMA INC | $4,410,000 | -56.1% | 376,900 | +34.0% | 0.65% | -50.6% |
| KZR | Buy | KEZAR LIFE SCIENCES INC | $4,239,000 | +14.7% | 711,200 | +0.5% | 0.62% | +29.0% |
| OPTN | Buy | OPTINOSE INC | $3,048,000 | +69.2% | 826,000 | +89.9% | 0.45% | +90.6% |
| CRNX | New | CRINETICS PHARMACEUTICALS INC | $2,873,000 | – | 188,000 | +100.0% | 0.42% | – |
| CAPA | New | HIGHCAPE CAPITAL ACQUISITION CORP | $2,876,000 | – | 241,300 | +100.0% | 0.42% | – |
| EDAP | Sell | EDAP TMS SAsponsored adr | $2,867,000 | -15.7% | 341,300 | -48.1% | 0.42% | -5.2% |
| SRRA | Buy | SIERRA ONCOLOGY INC | $2,604,000 | +115.6% | 151,139 | +100.5% | 0.38% | +141.8% |
| BHVN | Sell | BIOHAVEN PHARMACEUTICAL HLDG | $1,709,000 | -82.5% | 25,000 | -78.1% | 0.25% | -80.3% |
| ALPN | New | ALPINE IMMUNE SCIENCES INC | $1,659,000 | – | 156,500 | +100.0% | 0.24% | – |
| ARPO | New | AERPIO PHARMACEUTICALS INC | $1,290,000 | – | 1,000,000 | +100.0% | 0.19% | – |
| AYLA | New | AYALA PHARMECEUTICALS INC | $1,184,000 | – | 108,551 | +100.0% | 0.17% | – |
| CFRX | Sell | CONTRAFECT CORP | $1,171,000 | -47.3% | 244,000 | -44.5% | 0.17% | -40.7% |
| MGTA | Buy | MAGENTA THERAPEUTICS INC | $1,047,000 | +179.2% | 88,400 | +84.9% | 0.15% | +214.3% |
| VIRX | New | VIRACTA THERAPEUTICS INC | $958,000 | – | 103,600 | +100.0% | 0.14% | – |
| LPTX | New | LEAP THERAPEUTICS INC | $737,000 | – | 388,100 | +100.0% | 0.11% | – |
| BLRX | BIOLINERX LTDsponsored ads | $47,000 | +11.9% | 16,667 | 0.0% | 0.01% | +40.0% | |
| Exit | CATABASIS PHARMACEUTICALS INC | $0 | – | -187,750 | -100.0% | -0.05% | – | |
| AKUS | Exit | AKOUS INC | $0 | – | -45,459 | -100.0% | -0.12% | – |
| FULC | Exit | FULCRUM THERAPEUTICS INC | $0 | – | -88,300 | -100.0% | -0.14% | – |
| AMRN | Exit | AMARIN CORP PLCsponsored adr new | $0 | – | -225,000 | -100.0% | -0.14% | – |
| CNCE | Exit | CONCERT PHARMACEUTICALS INC | $0 | – | -254,000 | -100.0% | -0.42% | – |
| RYTM | Exit | RHYTHM PHARMACEUTICALS INC | $0 | – | -115,000 | -100.0% | -0.45% | – |
| PRAX | Exit | PRAXIS PRECISION MEDICINES INC | $0 | – | -63,416 | -100.0% | -0.46% | – |
| MRUS | Exit | MERUS NV | $0 | – | -353,000 | -100.0% | -0.81% | – |
| FPRX | Exit | FIVE PRIME THERAPEUTICS INC | $0 | – | -381,900 | -100.0% | -0.85% | – |
| INFI | Exit | INFINITY PHARMACEUTICALS INC | $0 | – | -3,171,800 | -100.0% | -0.88% | – |
| TCDA | Exit | TRICIDA INC | $0 | – | -959,000 | -100.0% | -0.88% | – |
| FSDC | Exit | FS DEV CORP | $0 | – | -704,400 | -100.0% | -1.01% | – |
| KALV | Exit | KALVISTA PHARMACEUTICALS INC | $0 | – | -470,203 | -100.0% | -1.17% | – |
| TGTX | Exit | TG THERAPEUTICS INC | $0 | – | -387,500 | -100.0% | -2.63% | – |
| CCXI | Exit | CHEMOCENTRYX INC | $0 | – | -350,000 | -100.0% | -2.83% | – |
| EIDX | Exit | EIDOS THERAPEUTICS INC | $0 | – | -315,550 | -100.0% | -5.42% | – |
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2021-05-18
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| CODEXIS INC | 39 | Q3 2023 | 10.9% |
| CHIMERIX INC | 31 | Q3 2022 | 16.4% |
| XOMA CORP DEL | 27 | Q3 2023 | 3.6% |
| FIBROGEN INC | 26 | Q1 2021 | 6.8% |
| BIOLINERX LTD (Does not reflect a reverse stock split effectuated after June 30, 2019) | 26 | Q1 2020 | 2.4% |
| OCULAR THERAPEUTIX INC | 24 | Q3 2023 | 17.6% |
| AXOGEN INC | 20 | Q4 2019 | 18.7% |
| ETON PHARMACEUTICALS INC | 20 | Q3 2023 | 5.6% |
| AMARIN CORP PLC | 20 | Q4 2020 | 6.6% |
| IMPRIMIS PHARMACEUTICALS INC | 19 | Q1 2020 | 5.9% |
View Opaleye Management Inc.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| CHIMERIX INCSold out | February 13, 2023 | 0 | 0.0% |
| Larimar Therapeutics, Inc. | January 23, 2023 | 1,560,000 | 3.6% |
| TELA Bio, Inc. | June 10, 2022 | 1,557,500 | 10.7% |
| Gemini Therapeutics, Inc. /DESold out | February 01, 2022 | 0 | 0.0% |
| Adamas Pharmaceuticals IncSold out | January 26, 2022 | 0 | 0.0% |
| AVENUE THERAPEUTICS, INC. | February 12, 2021 | 9 | 11.0% |
| Cardiff Oncology, Inc. | February 12, 2021 | 9 | 11.0% |
| EDAP TMS SA | February 12, 2021 | 9 | 11.0% |
| Fortress Biotech, Inc. | February 12, 2021 | 9 | 11.0% |
| Gemini Therapeutics, Inc. /DE | February 12, 2021 | 9 | 11.0% |
View Opaleye Management Inc.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 4 | 2024-04-25 |
| 4 | 2024-04-24 |
| 4 | 2024-04-19 |
| SC 13G/A | 2024-04-09 |
| SC 13G | 2024-04-08 |
| 4 | 2024-03-28 |
| 4 | 2024-03-22 |
| 13F-HR | 2024-02-14 |
| SC 13G/A | 2024-02-14 |
| SC 13G/A | 2024-02-14 |
View Opaleye Management Inc.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.