Opaleye Management Inc. Activity Q4 2013-Q3 2023

Q3 2023

			Value		Shares		↓ Weighting
HROW	Buy	HARROW HEALTH INC	$54,534,150	-24.1%	3,795,000	+0.5%	17.74%	+3.2%
	Sell	ACELYRIN INC	$42,166,223	-51.5%	4,146,138	-0.3%	13.72%	-34.0%
OCUL	Buy	OCULAR THERAPEUTIX INC	$20,309,520	-31.9%	6,468,000	+11.9%	6.61%	-7.4%
TGTX	New	TG THERAPEUTICS INC	$15,800,400	–	1,890,000	–	5.14%	–
RYTM	Sell	RHYTHM PHARMACEUTICALS INC	$14,970,025	+23.5%	653,000	-11.2%	4.87%	+68.0%
CPRX	New	CATALYST PHARMACEUTICALS INC	$14,086,450	–	1,205,000	–	4.58%	–
KROS	Buy	KEROS THERAPEUTICS INC	$11,489,552	-18.9%	360,400	+2.2%	3.74%	+10.3%
	Sell	BIOHAVEN LTD	$11,418,390	-11.6%	439,000	-18.7%	3.72%	+20.2%
CRNX	Sell	CRINETICS PHARMACEUTICALS INC	$11,003,800	-27.7%	370,000	-56.2%	3.58%	-1.7%
ETON	Buy	ETON PHARMACEUTICALS INC	$10,134,226	+27.1%	2,430,270	+6.4%	3.30%	+72.8%
IDYA	Sell	IDEAYA BIOSCIENCES INC	$8,404,270	-13.8%	311,500	-24.9%	2.73%	+17.2%
TELA	Sell	TELA BIO INC	$6,000,000	-62.5%	750,000	-52.5%	1.95%	-49.0%
EWTX	Buy	EDGEWISE THERAPEUTICS INC	$5,016,071	-20.6%	875,405	+7.4%	1.63%	+8.0%
KALV	Sell	KALVISTA PHARMACEUTICALS INC	$4,815,000	-25.7%	500,000	-30.6%	1.57%	+1.0%
	Sell	MARINUS PHARMACEUTICALS INC	$4,701,200	-30.7%	584,000	-6.6%	1.53%	-5.8%
PCVX	Sell	VAXCYTE INC	$4,588,200	-48.1%	90,000	-49.2%	1.49%	-29.4%
URGN	Sell	UROGEN PHARMA LTD	$4,483,200	-24.0%	320,000	-43.9%	1.46%	+3.4%
GERN	Sell	GERON CORP	$4,059,800	-46.2%	1,915,000	-18.5%	1.32%	-26.8%
GOSS	Buy	GOSSAMER BIO INC	$3,959,298	-2.1%	4,754,200	+41.1%	1.29%	+33.2%
FDMT	Buy	4D MOLECULAR THERAPEUTICS INC	$3,927,205	-2.0%	308,500	+39.2%	1.28%	+33.4%
XOMA	Sell	XOMA CORP DEL	$3,867,705	+550.3%	274,500	-0.2%	1.26%	+785.9%
TRVI	Buy	TREVI THERAPEUTICS INC	$3,718,862	-8.6%	1,705,900	+0.3%	1.21%	+24.4%
LRMR	Sell	LARIMAR THERAPEUTICS INC	$3,351,575	-23.0%	848,500	-39.0%	1.09%	+4.7%
	Sell	NYXOAH S A	$3,115,367	-12.6%	441,896	-0.7%	1.01%	+18.9%
	New	GOSSAMER BIO INCnote 5.000% 6/0	$3,098,704	–	8,000,000	–	1.01%	–
BDSX	New	BRIDGEBIO PHARMA INC	$3,038,295	–	455,573	–	0.99%	–
IOVA	Buy	IOVANCE BIOTHERAPEUTICS INC	$2,775,500	-6.4%	610,000	+44.9%	0.90%	+27.4%
APLT	New	APPLIED THERAPEUTICS	$2,223,570	–	893,000	–	0.72%	–
IGMS	Buy	IGM BIOSCIIENCES INC	$2,179,350	+271.8%	261,000	+311.0%	0.71%	+406.4%
CDXS	Buy	CODEXIS INC	$2,114,721	+11.9%	1,118,900	+65.8%	0.69%	+52.2%
	Buy	VERASTEM INC	$1,718,682	+126.5%	211,400	+107.3%	0.56%	+207.1%
PGEN	New	PRECIGEN INC	$1,318,470	–	928,500	–	0.43%	–
	New	XERIS BIOPHARMA HOLDINGS INC	$725,400	–	390,000	–	0.24%	–
FBIO	Sell	FORTRESS BIOTECH INC	$580,600	-68.1%	2,000,000	-39.6%	0.19%	-56.6%
KZR	Buy	KEZAR LIFE SCIENCES INC	$505,750	+108.9%	425,000	+330.2%	0.16%	+184.5%
RLMD	New	RELMADA THERAPEUTICS INC	$90,000	–	30,000	–	0.03%	–
FULC	Exit	FULCRUM THERAPEUTICS INC	$0	–	-143,600	–	-0.11%	–
JNCE	Exit	JASPER	$0	–	-669,944	–	-0.22%	–
PRQR	Exit	PROQR THERAPEUTICS NV	$0	–	-653,000	–	-0.25%	–
BDTX	Exit	BLACK DIAMOND THERAPEUTICS	$0	–	-275,000	–	-0.33%	–
STRO	Exit	SUTRO BIOPHARMA INC	$0	–	-307,000	–	-0.34%	–
	Exit	ASTRIA THERAPEUTICS INC	$0	–	-305,000	–	-0.61%	–
STXS	Exit	SPECTRUM PHARMACEUTICALS	$0	–	-3,074,995	–	-0.71%	–
KPTI	Exit	KARYOPHARM THERAPEUTICS INC	$0	–	-1,785,000	–	-0.76%	–
EDAP	Exit	EDAP TMS S Asponsored adr	$0	–	-380,000	–	-0.84%	–
CYTK	Exit	CYTOKINETICS INC	$0	–	-130,000	–	-1.01%	–
NTLA	Exit	INTELLIA THERAPEUTICS INC	$0	–	-120,000	–	-1.17%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INC	$0	–	-217,000	–	-1.24%	–
	Exit	THESEUS PHARMACEUTICALS INC	$0	–	-597,500	–	-1.33%	–
TBPH	Exit	THERAVANCE BIOPHARMA INC	$0	–	-543,500	–	-1.35%	–
CBAY	Exit	CYMABAY THERAPEUTICS INC	$0	–	-566,700	–	-1.48%	–

Q2 2023

			Value		Shares		↓ Weighting
	New	ACELYRIN INC	$86,915,534	–	4,158,638	–	20.79%	–
HROW	New	HARROW HEALTH INC	$71,876,000	–	3,775,000	–	17.19%	–
OCUL	New	OCULAR THERAPEUTIX INC	$29,824,800	–	5,780,000	–	7.13%	–
TELA	New	TELA BIO INC	$16,005,400	–	1,580,000	–	3.83%	–
CRNX	New	CRINETICS PHARMACEUTICALS INC	$15,226,900	–	845,000	–	3.64%	–
KROS	New	KEROS THERAPEUTICS INC	$14,169,477	–	352,650	–	3.39%	–
	New	BIOHAVEN LTD	$12,916,800	–	540,000	–	3.09%	–
RYTM	New	RHYTHM PHARMACEUTICALS INC	$12,120,150	–	735,000	–	2.90%	–
IDYA	New	IDEAYA BIOSCIENCES INC	$9,752,500	–	415,000	–	2.33%	–
MOR	New	MORPHOSYS AGsponsored ads	$9,034,069	–	1,209,380	–	2.16%	–
PCVX	New	VAXCYTE INC	$8,839,380	–	177,000	–	2.11%	–
ETON	New	ETON PHARMACEUTICALS INC	$7,974,650	–	2,285,000	–	1.91%	–
GERN	New	GERON CORP	$7,543,500	–	2,350,000	–	1.80%	–
	New	MARINUS PHARMACEUTICALS INC	$6,787,500	–	625,000	–	1.62%	–
KALV	New	KALVISTA PHARMACEUTICALS INC	$6,480,000	–	720,000	–	1.55%	–
TARA	New	PROTARA THERAPEUTICS INC	$6,435,300	–	2,692,594	–	1.54%	–
EWTX	New	EDGEWISE THERAPEUTICS INC	$6,316,250	–	815,000	–	1.51%	–
CBAY	New	CYMABAY THERAPEUTICS INC	$6,205,365	–	566,700	–	1.48%	–
URGN	New	UROGEN PHARMA LTD	$5,899,500	–	570,000	–	1.41%	–
TBPH	New	THERAVANCE BIOPHARMA INC	$5,625,225	–	543,500	–	1.35%	–
	New	THESEUS PHARMACEUTICALS INC	$5,574,675	–	597,500	–	1.33%	–
ACAD	New	ACADIA PHARMACEUTICALS INC	$5,197,150	–	217,000	–	1.24%	–
NTLA	New	INTELLIA THERAPEUTICS INC	$4,893,600	–	120,000	–	1.17%	–
LQDA	New	LIQUIDIA CORPORATION	$4,479,995	–	570,700	–	1.07%	–
LRMR	New	LARIMAR THERAPEUTICS INC	$4,350,700	–	1,390,000	–	1.04%	–
CYTK	New	CYTOKINETICS INC	$4,240,600	–	130,000	–	1.01%	–
TRVI	New	TREVI THERAPEUTICS INC	$4,066,585	–	1,701,500	–	0.97%	–
GOSS	New	GOSSAMER BIO INC	$4,044,000	–	3,370,000	–	0.97%	–
FDMT	New	4D MOLECULAR THERAPEUTICS INC	$4,006,119	–	221,700	–	0.96%	–
	New	NYXOAH S A	$3,564,450	–	445,000	–	0.85%	–
EDAP	New	EDAP TMS S Asponsored adr	$3,503,600	–	380,000	–	0.84%	–
KPTI	New	KARYOPHARM THERAPEUTICS INC	$3,195,150	–	1,785,000	–	0.76%	–
IOVA	New	IOVANCE BIOTHERAPEUTICS INC	$2,963,840	–	421,000	–	0.71%	–
STXS	New	SPECTRUM PHARMACEUTICALS	$2,951,995	–	3,074,995	–	0.71%	–
	New	ASTRIA THERAPEUTICS INC	$2,540,650	–	305,000	–	0.61%	–
CDXS	New	CODEXIS INC	$1,890,000	–	675,000	–	0.45%	–
FBIO	New	FORTRESS BIOTECH INC	$1,820,500	–	3,310,000	–	0.44%	–
STRO	New	SUTRO BIOPHARMA INC	$1,427,550	–	307,000	–	0.34%	–
TCON	New	TRACON PHARMACEUTICALS INC	$1,386,472	–	4,764,508	–	0.33%	–
BDTX	New	BLACK DIAMOND THERAPEUTICS	$1,388,750	–	275,000	–	0.33%	–
PRQR	New	PROQR THERAPEUTICS NV	$1,057,860	–	653,000	–	0.25%	–
JNCE	New	JASPER	$917,823	–	669,944	–	0.22%	–
	New	VERASTEM INC	$758,880	–	102,000	–	0.18%	–
XOMA	New	XOMA CORP DEL	$594,750	–	275,000	–	0.14%	–
IGMS	New	IGM BIOSCIIENCES INC	$586,105	–	63,500	–	0.14%	–
FULC	New	FULCRUM THERAPEUTICS INC	$473,880	–	143,600	–	0.11%	–
KZR	New	KEZAR LIFE SCIENCES INC	$242,050	–	98,796	–	0.06%	–

Q4 2022

			Value		Shares		↓ Weighting
BLRX	Exit	BIOLINERX LTDsponsored ads	$0	–	-16,667	–	-0.01%	–
IDYA	Exit	IDEAYA BIOSCIENCES INC	$0	–	-1,500	–	-0.01%	–
MGTX	Exit	MEIRAGTX HLDGS PLC	$0	–	-10,000	–	-0.04%	–
OPTN	Exit	OPTINOSE INC	$0	–	-90,970	–	-0.14%	–
NLTX	Exit	NEOLEUKIN THERAPEUTICS INC	$0	–	-575,000	–	-0.15%	–
LUMO	Exit	LUMOS PHARMA INC	$0	–	-46,576	–	-0.17%	–
NPCE	Exit	NEUROPACE INC	$0	–	-116,324	–	-0.18%	–
EDAP	Exit	EDAP TMS SAsponsored adr	$0	–	-71,300	–	-0.24%	–
MOR	Exit	MORPHOSYS AGsponsored ads	$0	–	-121,015	–	-0.25%	–
	Exit	JOURNEY MEDICINE CORP	$0	–	-259,293	–	-0.26%	–
CMRX	Exit	CHIMERIX INC	$0	–	-365,000	–	-0.29%	–
ALLK	Exit	ALLAKOS INC	$0	–	-153,500	–	-0.39%	–
	Exit	MODULAR MEDICAL INC	$0	–	-275,422	–	-0.47%	–
	Exit	ASTRIA THERAPEUTICS INC	$0	–	-133,500	–	-0.50%	–
IMPL	Exit	IMPEL PHARMACEUTICALS INC	$0	–	-255,250	–	-0.51%	–
	Exit	THESEUS PHARMACEUTICALS INC	$0	–	-220,650	–	-0.53%	–
GRPH	Exit	GRAPHITE BIO INC	$0	–	-577,250	–	-0.76%	–
PRQR	Exit	PROQR THERAPEUTICS NV	$0	–	-3,115,000	–	-0.96%	–
FBIO	Exit	FORTRESS BIOTECH INC	$0	–	-2,999,000	–	-1.06%	–
STXS	Exit	STEREOTAXIS INC	$0	–	-1,556,800	–	-1.16%	–
FDMT	Exit	4D MOLECULAR THERAPEUTICS INC	$0	–	-350,700	–	-1.16%	–
LQDA	Exit	LIQUIDIA CORPORATION	$0	–	-563,500	–	-1.27%	–
URGN	Exit	UROGEN PHARMA LTD	$0	–	-397,500	–	-1.37%	–
XOMA	Exit	XOMA CORP DEL	$0	–	-248,000	–	-1.84%	–
PCVX	Exit	VAXCYTE INC	$0	–	-190,000	–	-1.88%	–
MRUS	Exit	MERUS N.V.	$0	–	-253,200	–	-2.10%	–
INBX	Exit	INHIBRX INC	$0	–	-292,700	–	-2.17%	–
ETON	Exit	ETON PHARMACEUTICALS INC	$0	–	-2,521,000	–	-2.19%	–
LRMR	Exit	LARIMAR THERAPEUTICS INC	$0	–	-1,661,784	–	-2.20%	–
MRSN	Exit	MERSANA THERAPEUTICS INC	$0	–	-900,300	–	-2.51%	–
EWTX	Exit	EDGEWISE THERAPEUTICS INC	$0	–	-635,000	–	-2.58%	–
CUTR	Exit	CUTERA INC	$0	–	-147,700	–	-2.78%	–
TCON	Exit	TRACON PHARMACEUTICALS INC	$0	–	-4,190,000	–	-2.89%	–
CDXS	Exit	CODEXIS INC	$0	–	-1,155,000	–	-2.89%	–
TARA	Exit	PROTARA THERAPEUTICS INC	$0	–	-2,708,067	–	-3.30%	–
KROS	Exit	KEROS THERAPEUTICS INC	$0	–	-321,300	–	-4.99%	–
CYTK	Exit	CYTOKINETICS INC	$0	–	-263,000	–	-5.26%	–
CRNX	Exit	CRINETICS PHARMACEUTICALS INC	$0	–	-671,300	–	-5.44%	–
TELA	Exit	TELA BIO INC	$0	–	-2,036,551	–	-7.17%	–
RYTM	Exit	RHYTHM PHARMACEUTICALS INC	$0	–	-810,000	–	-8.20%	–
OCUL	Exit	OCULAR THERAPEUTIX INC	$0	–	-6,465,000	–	-11.08%	–
HROW	Exit	HARROW HEALTH INC	$0	–	-3,343,817	–	-16.67%	–

Q3 2022

			Value		Shares		↓ Weighting
HROW	Buy	HARROW HEALTH INC	$40,360,000	+66.4%	3,343,817	+0.3%	16.67%	+52.4%
OCUL	Buy	OCULAR THERAPEUTIX INC	$26,830,000	+11.7%	6,465,000	+8.2%	11.08%	+2.4%
RYTM	Buy	RHYTHM PHARMACEUTICALS INC	$19,845,000	+1221.2%	810,000	+123.8%	8.20%	+1110.6%
TELA	Buy	TELA BIO INC	$17,351,000	+50.6%	2,036,551	+23.9%	7.17%	+38.0%
CYTK	Sell	CYTOKINETICS INC	$12,742,000	+7.2%	263,000	-13.1%	5.26%	-1.8%
KROS	Buy	KEROS THERAPEUTICS INC	$12,087,000	+58.5%	321,300	+16.4%	4.99%	+45.2%
TARA	Buy	PROTARA THERAPEUTICS INC	$7,993,000	-10.0%	2,708,067	+0.9%	3.30%	-17.6%
CDXS	Sell	CODEXIS INC	$6,999,000	-48.1%	1,155,000	-10.4%	2.89%	-52.4%
TCON	Buy	TRACON PHARMACEUTICALS INC	$6,997,000	-15.2%	4,190,000	+1.6%	2.89%	-22.3%
EWTX	Buy	EDGEWISE THERAPEUTICS INC	$6,248,000	+73.9%	635,000	+40.7%	2.58%	+59.3%
MRSN	Sell	MERSANA THERAPEUTICS INC	$6,086,000	+25.8%	900,300	-14.0%	2.51%	+15.3%
LRMR	Buy	LARIMAR THERAPEUTICS INC	$5,318,000	+190.9%	1,661,784	+78.1%	2.20%	+166.5%
ETON	Buy	ETON PHARMACEUTICALS INC	$5,294,000	-17.9%	2,521,000	+2.4%	2.19%	-24.8%
INBX	Sell	INHIBRX INC	$5,254,000	-21.5%	292,700	-50.4%	2.17%	-28.1%
MRUS	Sell	MERUS N.V.	$5,072,000	-33.7%	253,200	-25.1%	2.10%	-39.3%
XOMA	Sell	XOMA CORP DEL	$4,442,000	-24.2%	248,000	-5.7%	1.84%	-30.5%
URGN	Buy	UROGEN PHARMA LTD	$3,307,000	+69.2%	397,500	+66.5%	1.37%	+55.1%
LQDA	Buy	LIQUIDIA CORPORATION	$3,065,000	+34.8%	563,500	+8.1%	1.27%	+23.5%
FDMT	Buy	4D MOLECULAR THERAPEUTICS INC	$2,820,000	+24.3%	350,700	+7.9%	1.16%	+13.9%
STXS	Sell	STEREOTAXIS INC	$2,802,000	-27.5%	1,556,800	-25.9%	1.16%	-33.6%
FBIO	Sell	FORTRESS BIOTECH INC	$2,579,000	-5.4%	2,999,000	-7.6%	1.06%	-13.3%
PRQR	Buy	PROQR THERAPEUTICS NV	$2,318,000	+8.8%	3,115,000	+13.7%	0.96%	-0.4%
GRPH	Buy	GRAPHITE BIO INC	$1,830,000	+44.7%	577,250	+25.5%	0.76%	+32.6%
	Buy	THESEUS PHARMACEUTICALS INC	$1,280,000	+615.1%	220,650	+583.1%	0.53%	+553.1%
IMPL	Buy	IMPEL PHARMACEUTICALS INC	$1,243,000	-7.8%	255,250	+76.5%	0.51%	-15.6%
	New	ASTRIA THERAPEUTICS INC	$1,207,000	–	133,500	–	0.50%	–
ALLK	New	ALLAKOS INC	$939,000	–	153,500	–	0.39%	–
CMRX	Sell	CHIMERIX INC	$704,000	-76.3%	365,000	-74.5%	0.29%	-78.3%
	Buy	JOURNEY MEDICINE CORP	$638,000	-30.6%	259,293	+5.5%	0.26%	-36.5%
MOR	New	MORPHOSYS AGsponsored ads	$609,000	–	121,015	–	0.25%	–
EDAP	New	EDAP TMS SAsponsored adr	$588,000	–	71,300	–	0.24%	–
NPCE	Buy	NEUROPACE INC	$436,000	-2.2%	116,324	+29.1%	0.18%	-10.4%
LUMO	Buy	LUMOS PHARMA INC	$412,000	+148.2%	46,576	+116.4%	0.17%	+126.7%
NLTX	Sell	NEOLEUKIN THERAPEUTICS INC	$368,000	-41.4%	575,000	-5.7%	0.15%	-46.3%
MGTX	New	MEIRAGTX HLDGS PLC	$84,000	–	10,000	–	0.04%	–
IDYA	New	IDEAYA BIOSCIENCES INC	$22,000	–	1,500	–	0.01%	–
	Exit	AVALO THERAPEUTICS INC	$0	–	-450,000	–	-0.10%	–
	Exit	MARINUS PHARMACEUTICALS INC	$0	–	-68,900	–	-0.15%	–
FMTX	Exit	FORMA THERAPEUTICS HLDGS INC	$0	–	-58,700	–	-0.18%	–
MGNX	Exit	MACROGENICS INC	$0	–	-208,300	–	-0.28%	–
	Exit	HYPERFINE INC	$0	–	-763,075	–	-0.77%	–
VSTM	Exit	VERASTEM INC	$0	–	-1,590,000	–	-0.83%	–
	Exit	GINKGO BIOWORKS HOLDINGS INCclass a shares	$0	–	-815,000	–	-0.87%	–
CLDX	Exit	CELLDEX THERAPEUTICS INC NEW	$0	–	-90,000	–	-1.09%	–
MASS	Exit	908 DEVICES INC	$0	–	-166,406	–	-1.54%	–
RETA	Exit	REATA PHARMACEUTICALS INCclass a	$0	–	-183,750	–	-2.52%	–
KNSA	Exit	KINIKSA PHARMACEUTICALS LTD	$0	–	-814,250	–	-3.56%	–

Q2 2022

			Value		Shares		↓ Weighting
HROW	New	HARROW HEALTH INC	$24,262,000	–	3,332,732	–	10.94%	–
OCUL	New	OCULAR THERAPEUTIX INC	$24,019,000	–	5,974,800	–	10.83%	–
CDXS	New	CODEXIS INC	$13,477,000	–	1,288,450	–	6.08%	–
CRNX	New	CRINETICS PHARMACEUTICALS INC	$12,520,000	–	671,300	–	5.64%	–
CYTK	New	CYTOKINETICS INC	$11,885,000	–	302,500	–	5.36%	–
TELA	New	TELA BIO INC	$11,520,000	–	1,643,367	–	5.19%	–
TARA	New	PROTARA THERAPEUTICS INC	$8,885,000	–	2,684,167	–	4.00%	–
TCON	New	TRACON PHARMACEUTICALS INC	$8,251,000	–	4,125,322	–	3.72%	–
KNSA	New	KINIKSA PHARMACEUTICALS LTD	$7,890,000	–	814,250	–	3.56%	–
MRUS	New	MERUS N.V.	$7,652,000	–	338,000	–	3.45%	–
KROS	New	KEROS THERAPEUTICS INC	$7,626,000	–	276,000	–	3.44%	–
INBX	New	INHIBRX INC	$6,697,000	–	590,000	–	3.02%	–
ETON	New	ETON PHARMACEUTICALS INC	$6,452,000	–	2,462,500	–	2.91%	–
XOMA	New	XOMA CORP DEL	$5,861,000	–	263,050	–	2.64%	–
RETA	New	REATA PHARMACEUTICALS INCclass a	$5,584,000	–	183,750	–	2.52%	–
CUTR	New	CUTERA	$5,539,000	–	147,700	–	2.50%	–
MRSN	New	MERSANA THERAPEUTICS INC	$4,837,000	–	1,047,000	–	2.18%	–
PCVX	New	VAXCYTE INC	$4,134,000	–	190,000	–	1.86%	–
STXS	New	STEREOTAXIS INC	$3,864,000	–	2,099,971	–	1.74%	–
EWTX	New	EDGEWISE THERAPEUTICS INC	$3,593,000	–	451,400	–	1.62%	–
MASS	New	908 DEVICES INC	$3,426,000	–	166,406	–	1.54%	–
CMRX	New	CHIMERIX INC	$2,974,000	–	1,430,000	–	1.34%	–
FBIO	New	FORTRESS BIOTECH INC	$2,727,000	–	3,247,180	–	1.23%	–
CLDX	New	CELLDEX THERAPEUTICS INC NEW	$2,426,000	–	90,000	–	1.09%	–
LQDA	New	LIQUIDIA CORPORATION	$2,274,000	–	521,500	–	1.02%	–
FDMT	New	4D MOLECULAR THERAPEUTICS INC	$2,269,000	–	325,000	–	1.02%	–
PRQR	New	PROQR THERAPEUTICS NV	$2,131,000	–	2,740,000	–	0.96%	–
URGN	New	UROGEN PHARMA LTD	$1,955,000	–	238,670	–	0.88%	–
	New	GINKGO BIOWORKS HOLDINGS INCclass a shares	$1,940,000	–	815,000	–	0.87%	–
VSTM	New	VERASTEM INC	$1,844,000	–	1,590,000	–	0.83%	–
LRMR	New	LARIMAR THERAPEUTICS INC	$1,828,000	–	932,814	–	0.82%	–
	New	HYPERFINE INC	$1,702,000	–	763,075	–	0.77%	–
RYTM	New	RHYTHM PHARMACEUTICALS INC	$1,502,000	–	362,000	–	0.68%	–
	New	MODULAR MEDICAL INC	$1,427,000	–	275,422	–	0.64%	–
IMPL	New	IMPEL PHARMACEUTICALS INC	$1,348,000	–	144,642	–	0.61%	–
GRPH	New	GRAPHITE BIO INC	$1,265,000	–	460,000	–	0.57%	–
	New	JOURNEY MEDICINE CORP	$919,000	–	245,733	–	0.41%	–
NLTX	New	NEOLEUKIN THERAPEUTICS INC	$628,000	–	610,000	–	0.28%	–
MGNX	New	MACROGENICS INC	$614,000	–	208,300	–	0.28%	–
NPCE	New	NEUROPACE INC	$446,000	–	90,100	–	0.20%	–
FMTX	New	FORMA THERAPEUTICS HLDGS INC	$404,000	–	58,700	–	0.18%	–
OPTN	New	OPTINOSE INC	$333,000	–	90,970	–	0.15%	–
	New	MARINUS PHARMACEUTICALS INC	$333,000	–	68,900	–	0.15%	–
	New	AVALO THERAPEUTICS INC	$225,000	–	450,000	–	0.10%	–
	New	THESEUS PHARMACEUTICALS INC	$179,000	–	32,300	–	0.08%	–
LUMO	New	LUMOS PHARMA INC	$166,000	–	21,520	–	0.08%	–
BLRX	New	BIOLINERX LTDsponsored ads	$21,000	–	16,667	–	0.01%	–

Q4 2021

			Value		Shares		↓ Weighting
BLRX	Exit	BIOLINERX LTDsponsored ads	$0	–	-16,667	–	-0.01%	–
CBAY	Exit	CYMABAY THERAPEUTICS INC	$0	–	-115,015	–	-0.08%	–
SELB	Exit	SELECTA BIOSCIENCES INC	$0	–	-106,000	–	-0.08%	–
AKBA	Exit	AKEBIA THERAPEUTICS INC	$0	–	-311,300	–	-0.17%	–
	Exit	APTOSE BIOSCIENCES INC	$0	–	-549,000	–	-0.22%	–
NCNA	Exit	NUCANA PLCsponsored adr	$0	–	-479,600	–	-0.23%	–
	Exit	AADI BIOSCIENCES INC	$0	–	-45,020	–	-0.25%	–
DTIL	Exit	PRECISION BIOSCIENCES INC	$0	–	-163,900	–	-0.35%	–
LPTX	Exit	LEAP THERAPEUTICS INC	$0	–	-476,000	–	-0.36%	–
SIOX	Exit	SIO GENE THERAPIES INC	$0	–	-955,000	–	-0.39%	–
VIRX	Exit	VIRACTA THERAPEUTICS INC	$0	–	-258,556	–	-0.39%	–
MRUS	Exit	MERUS N.V.	$0	–	-100,250	–	-0.41%	–
AVEO	Exit	AVEO BIOSCIENCES INC	$0	–	-455,600	–	-0.53%	–
FOLD	Exit	AMICUS THERAPEUTICS INC	$0	–	-320,800	–	-0.57%	–
	Exit	AVALO THERAPEUTICS INC	$0	–	-1,459,400	–	-0.59%	–
SRRA	Exit	SIERRA ONCOLOGY INC	$0	–	-165,778	–	-0.68%	–
FMTX	Exit	FORMA THERAPEUTICS HOLDINGS INC	$0	–	-182,950	–	-0.79%	–
MEIP	Exit	MEI PHARMA INC	$0	–	-1,565,000	–	-0.81%	–
OPTN	Exit	OPTINOSE INC	$0	–	-1,558,500	–	-0.87%	–
AFIB	Exit	ACUTUS MEDICAL INC	$0	–	-590,000	–	-0.97%	–
PTGX	Exit	PROTAGONIST THERAPEUTICS INC	$0	–	-330,222	–	-1.09%	–
TELA	Exit	TELA BIO INC	$0	–	-443,199	–	-1.13%	–
DCPH	Exit	DECIPHERA PHARMACEUTICALS IN	$0	–	-205,381	–	-1.30%	–
VSTM	Exit	VERASTEM INC	$0	–	-2,325,000	–	-1.34%	–
ADMS	Exit	ADAMAS PHARMACEUTICALS INC	$0	–	-1,460,000	–	-1.34%	–
NLTX	Exit	NEOLEUKIN THERAPEUTICS INC	$0	–	-1,047,300	–	-1.41%	–
XOMA	Exit	XOMA CORP DEL	$0	–	-338,350	–	-1.56%	–
CRNX	Exit	CRINETICS PHARMACEUTICALS INC	$0	–	-402,113	–	-1.58%	–
PCVX	Exit	VAXCYTE INC	$0	–	-353,400	–	-1.68%	–
LRMR	Exit	LARIMAR THERAPEUTICS INC	$0	–	-832,807	–	-1.79%	–
MGNX	Exit	MACROGENICS INC	$0	–	-462,000	–	-1.81%	–
TCON	Exit	TRACON PHARMACEUTICALS INC	$0	–	-2,518,371	–	-1.82%	–
STRO	Exit	SUTRO BIOPHARMA INC	$0	–	-537,800	–	-1.90%	–
PRQR	Exit	PROQR THERAPEUTICS NV	$0	–	-1,424,200	–	-2.23%	–
FBIO	Exit	FORTRESS BIOTECH INC	$0	–	-3,750,000	–	-2.26%	–
STXS	Exit	STEREOTAXIS INC	$0	–	-2,526,500	–	-2.54%	–
KROS	Exit	KEROS THERAPEUTICS INC	$0	–	-352,500	–	-2.60%	–
KNSA	Exit	KINIKSA PHARMACEUTICALS LTD	$0	–	-1,310,000	–	-2.79%	–
ETON	Exit	ETON PHARMACEUTICALS INC	$0	–	-3,088,100	–	-2.91%	–
TARA	Exit	PROTARA THERAPEUTICS INC	$0	–	-2,558,472	–	-3.31%	–
CYTK	Exit	CYTOKINETICS INC	$0	–	-580,000	–	-3.87%	–
BBIO	Exit	BRIDGEBIO PHARMA INC	$0	–	-511,500	–	-4.48%	–
SMLR	Exit	SEMLER SCIENTIFIC INC	$0	–	-225,566	–	-5.27%	–
HROW	Exit	HARROW HEALTH INC	$0	–	-3,285,000	–	-5.58%	–
CMRX	Exit	CHIMERIX INC	$0	–	-5,030,000	–	-5.82%	–
CDXS	Exit	CODEXIS INC	$0	–	-1,345,000	–	-5.84%	–
CLDX	Exit	CELLDEX THERAPEUTICS INC	$0	–	-985,000	–	-9.91%	–
OCUL	Exit	OCULAR THERAPEUTIX INC	$0	–	-6,480,000	–	-12.10%	–

Q3 2021

			Value		Shares		↓ Weighting
CMRX	Buy	CHIMERIX INC	$31,136,000	-15.9%	5,030,000	+8.6%	5.82%	-5.5%
HROW	Buy	HARROW HEALTH INC	$29,861,000	+2.4%	3,285,000	+4.6%	5.58%	+15.1%
SMLR	New	SEMLER SCIENTIFIC INC	$28,203,000	–	225,566	–	5.27%	–
BBIO	Sell	BRIDGEBIO PHARMA INC	$23,974,000	-24.0%	511,500	-1.1%	4.48%	-14.5%
ETON	Sell	ETON PHARMACEUTICALS INC	$15,564,000	-46.9%	3,088,100	-16.4%	2.91%	-40.3%
KNSA	Buy	KINIKSA PHARMACEUTICALS LTD	$14,921,000	-7.3%	1,310,000	+13.4%	2.79%	+4.3%
KROS	Buy	KEROS THERAPEUTICS INC	$13,945,000	+39.7%	352,500	+50.0%	2.60%	+57.1%
FBIO	Sell	FORTRESS BIOTECH INC	$12,075,000	-12.7%	3,750,000	-3.2%	2.26%	-1.9%
PRQR	Buy	PROQR THERAPEUTICS NV	$11,921,000	+28.1%	1,424,200	+3.2%	2.23%	+44.1%
STRO	Buy	SUTRO BIOPHARMA INC	$10,159,000	+10.0%	537,800	+8.2%	1.90%	+23.7%
MGNX	Sell	MACROGENICS INC	$9,674,000	-37.7%	462,000	-20.1%	1.81%	-29.9%
LRMR	Buy	LARIMAR THERAPEUTICS INC	$9,602,000	+34.4%	832,807	+14.4%	1.79%	+51.1%
PCVX	Sell	VAXCYTE INC	$8,966,000	+11.3%	353,400	-1.2%	1.68%	+25.2%
CRNX	Buy	CRINETICS PHARMACEUTICALS INC	$8,464,000	+124.0%	402,113	+100.6%	1.58%	+151.8%
XOMA	Sell	XOMA CORP DEL	$8,374,000	-28.3%	338,350	-1.5%	1.56%	-19.4%
NLTX	Sell	NEOLEUKIN THERAPEUTICS INC	$7,572,000	-29.0%	1,047,300	-9.4%	1.41%	-20.2%
ADMS	Sell	ADAMAS PHARMACEUTICALS INC	$7,169,000	-18.7%	1,460,000	-12.6%	1.34%	-8.6%
TELA	Buy	TELA BIO INC	$6,054,000	-14.7%	443,199	+0.6%	1.13%	-4.1%
AFIB	Sell	ACUTUS MEDICAL INC	$5,216,000	-48.8%	590,000	-1.7%	0.97%	-42.4%
OPTN	Buy	OPTINOSE INC	$4,676,000	+22.6%	1,558,500	+27.1%	0.87%	+37.7%
FMTX	Buy	FORMA THERAPEUTICS HOLDINGS INC	$4,243,000	-0.3%	182,950	+7.0%	0.79%	+12.2%
SRRA	Buy	SIERRA ONCOLOGY INC	$3,634,000	+12.8%	165,778	+0.2%	0.68%	+26.9%
	New	AVALO THERAPEUTICS INC	$3,181,000	–	1,459,400	–	0.59%	–
FOLD	New	AMICUS THERAPEUTICS INC	$3,064,000	–	320,800	–	0.57%	–
AVEO	Sell	AVEO BIOSCIENCES INC	$2,816,000	-34.0%	455,600	-29.6%	0.53%	-25.7%
MRUS	New	MERUS N.V.	$2,206,000	–	100,250	–	0.41%	–
VIRX	Buy	VIRACTA THERAPEUTICS INC	$2,074,000	-28.9%	258,556	+0.5%	0.39%	-20.2%
SIOX	Sell	SIO GENE THERAPIES INC	$2,072,000	-60.6%	955,000	-52.2%	0.39%	-55.7%
LPTX	Sell	LEAP THERAPEUTICS INC	$1,909,000	+115.5%	476,000	-11.9%	0.36%	+142.9%
DTIL	New	PRECISION BIOSCIENCES INC	$1,891,000	–	163,900	–	0.35%	–
	New	AADI BIOSCIENCES INC	$1,322,000	–	45,020	–	0.25%	–
NCNA	New	NUCANA PLCsponsored adr	$1,237,000	–	479,600	–	0.23%	–
	Sell	APTOSE BIOSCIENCES INC	$1,197,000	-63.2%	549,000	-44.0%	0.22%	-58.5%
AKBA	New	AKEBIA THERAPEUTICS INC	$897,000	–	311,300	–	0.17%	–
SELB	New	SELECTA BIOSCIENCES INC	$441,000	–	106,000	–	0.08%	–
CBAY	New	CYMABAY THERAPEUTICS INC	$420,000	–	115,015	–	0.08%	–
CDTX	Exit	CIDARA THERAPEUTICS INC	$0	–	-73,351	–	-0.02%	–
CFRX	Exit	CONTRAFECT CORP	$0	–	-57,900	–	-0.04%	–
PHVS	Exit	PHARVARIS NV	$0	–	-79,837	–	-0.25%	–
CRDF	Exit	CARDIFF ONCOLOGY INC	$0	–	-463,000	–	-0.51%	–
KZR	Exit	KEZAR LIFE SCIENCES INC	$0	–	-697,800	–	-0.63%	–
LUMO	Exit	LUMOS PHARMA INC	$0	–	-382,000	–	-0.63%	–
CERC	Exit	CERECOR INC	$0	–	-1,567,494	–	-0.85%	–
CMLF	Exit	CM LIFE SCIENCES INC	$0	–	-373,828	–	-0.87%	–
MCRB	Exit	SERES THERAPEUTICS INC	$0	–	-250,000	–	-0.99%	–
EPIX	Exit	ESSA PHARMA INC	$0	–	-284,050	–	-1.35%	–

Q2 2021

			Value		Shares		↓ Weighting
OCUL	New	OCULAR THERAPEUTIX INC	$91,886,000	–	6,480,000	–	15.26%	–
CMRX	New	CHIMERIX INC	$37,040,000	–	4,630,000	–	6.15%	–
CLDX	New	CELLDEX THERAPEUTICS INC	$32,938,000	–	985,000	–	5.47%	–
BBIO	New	BRIDGEBIO PHARMA INC	$31,525,000	–	517,150	–	5.24%	–
CDXS	New	CODEXIS INC	$30,478,000	–	1,345,000	–	5.06%	–
ETON	New	ETON PHARMACEUTICALS INC	$29,310,000	–	3,692,600	–	4.87%	–
HROW	New	HARROW HEALTH INC	$29,171,000	–	3,140,000	–	4.84%	–
TARA	New	PROTARA THERAPEUTICS INC	$24,920,000	–	2,558,472	–	4.14%	–
STXS	New	STEREOTAXIS INC	$24,355,000	–	2,526,500	–	4.04%	–
TCON	New	TRACON PHARMACEUTICALS INC	$16,344,000	–	2,518,371	–	2.72%	–
KNSA	New	KINIKSA PHARMACEUTICALS LTD	$16,092,000	–	1,155,200	–	2.67%	–
MGNX	New	MACROGENICS INC	$15,529,000	–	578,150	–	2.58%	–
PTGX	New	PROTAGONIST THERAPEUTICS INC	$14,820,000	–	330,222	–	2.46%	–
FBIO	New	FORTRESS BIOTECH INC	$13,834,000	–	3,875,000	–	2.30%	–
XOMA	New	XOMA CORP DEL	$11,682,000	–	343,600	–	1.94%	–
CYTK	New	CYTOKINETICS INC	$11,478,000	–	580,000	–	1.91%	–
NLTX	New	NEOLEUKIN THERAPEUTICS INC	$10,672,000	–	1,156,200	–	1.77%	–
AFIB	New	ACUTUS MEDICAL INC	$10,188,000	–	599,990	–	1.69%	–
KROS	New	KEROS THERAPEUTICS INC	$9,980,000	–	235,000	–	1.66%	–
VSTM	New	VERASTEM INC	$9,463,000	–	2,325,000	–	1.57%	–
PRQR	New	PROQR THERAPEUTICS NV	$9,304,000	–	1,380,400	–	1.54%	–
STRO	New	SUTRO BIOPHARMA INC	$9,237,000	–	496,900	–	1.53%	–
ADMS	New	ADAMAS PHARMACEUTICALS INC	$8,821,000	–	1,670,600	–	1.46%	–
EPIX	New	ESSA PHARMA INC	$8,115,000	–	284,050	–	1.35%	–
PCVX	New	VAXCYTE INC	$8,054,000	–	357,800	–	1.34%	–
DCPH	New	DECIPHERA PHARMACEUTICALS IN	$7,519,000	–	205,381	–	1.25%	–
LRMR	New	LARIMAR THERAPEUTICS INC	$7,147,000	–	727,800	–	1.19%	–
TELA	New	TELA BIO INC	$7,096,000	–	440,465	–	1.18%	–
MCRB	New	SERES THERAPEUTICS INC	$5,963,000	–	250,000	–	0.99%	–
SIOX	New	SIO GENE THERAPIES INC	$5,258,000	–	2,000,000	–	0.87%	–
CMLF	New	CM LIFE SCIENCES INC	$5,237,000	–	373,828	–	0.87%	–
CERC	New	CERECOR INC	$5,126,000	–	1,567,494	–	0.85%	–
MEIP	New	MEI PHARMA INC	$4,460,000	–	1,565,000	–	0.74%	–
AVEO	New	AVEO BIOSCIENCES INC	$4,264,000	–	647,000	–	0.71%	–
FMTX	New	FORMA THERAPEUTICS HOLDINGS INC	$4,256,000	–	171,000	–	0.71%	–
OPTN	New	OPTINOSE INC	$3,815,000	–	1,226,600	–	0.63%	–
LUMO	New	LUMOS PHARMA INC	$3,820,000	–	382,000	–	0.63%	–
KZR	New	KEZAR LIFE SCIENCES INC	$3,789,000	–	697,800	–	0.63%	–
CRNX	New	CRINETICS PHARMACEUTICALS INC	$3,779,000	–	200,500	–	0.63%	–
	New	APTOSE BIOSCIENCES INC	$3,254,000	–	980,000	–	0.54%	–
SRRA	New	SIERRA ONCOLOGY INC	$3,222,000	–	165,500	–	0.54%	–
CRDF	New	CARDIFF ONCOLOGY INC	$3,079,000	–	463,000	–	0.51%	–
VIRX	New	VIRACTA THERAPEUTICS INC	$2,917,000	–	257,189	–	0.48%	–
PHVS	New	PHARVARIS NV	$1,487,000	–	79,837	–	0.25%	–
LPTX	New	LEAP THERAPEUTICS INC	$886,000	–	540,000	–	0.15%	–
CFRX	New	CONTRAFECT CORP	$255,000	–	57,900	–	0.04%	–
CDTX	New	CIDARA THERAPEUTICS INC	$148,000	–	73,351	–	0.02%	–
BLRX	New	BIOLINERX LTDsponsored ads	$47,000	–	16,667	–	0.01%	–

Q4 2020

			Value		Shares		↓ Weighting
MRUS	Exit	MERUS NV	$0	–	-200	–	0.00%	–
BLRX	Exit	BIOLINERX LTDsponsored ads	$0	–	-16,667	–	-0.01%	–
INFI	Exit	INFINITY PHARMACEUTICALS INC	$0	–	-3,171,800	–	-0.03%	–
PIRS	Exit	PIERIS PHARMACEUTICALS INC	$0	–	-145,000	–	-0.06%	–
ONCT	Exit	ONCTERNAL THERAPEUTICS INC	$0	–	-194,541	–	-0.06%	–
XFOR	Exit	X4 PHARMACEUTICALS INC	$0	–	-75,000	–	-0.10%	–
AMRN	Exit	AMARIN CORP PLCsponsored adr new	$0	–	-225,000	–	-0.18%	–
CNCE	Exit	CONCERT PHARMACEUTICALS INC	$0	–	-100,000	–	-0.19%	–
CFRX	Exit	CONTRAFECT INC	$0	–	-226,127	–	-0.23%	–
STRO	Exit	SUTRO BIOPHARMA INC	$0	–	-146,000	–	-0.29%	–
EPIX	Exit	ESSA PHARMA INC	$0	–	-271,350	–	-0.37%	–
OM	Exit	OUTSET MED INC	$0	–	-45,000	–	-0.44%	–
NERV	Exit	MINERVA NEUROSCIENCES INC	$0	–	-767,400	–	-0.48%	–
AGLE	Exit	AEGLEA BIOTHERAPEUTICS INC	$0	–	-375,000	–	-0.52%	–
CDTX	Exit	CIDARA THERAPEUTICS INC	$0	–	-970,664	–	-0.54%	–
VSTM	Exit	VERASTEM INC	$0	–	-2,200,000	–	-0.63%	–
KZR	Exit	KEZAR LIFE SCIENCES INC	$0	–	-678,000	–	-0.64%	–
LUMO	Exit	LUMOS PHARMA INC	$0	–	-240,892	–	-0.65%	–
FULC	Exit	FULCRUM THERAPEUTICS INC	$0	–	-452,000	–	-0.70%	–
CRNX	Exit	CRINETICS PHARMACEUTICALS INC	$0	–	-240,000	–	-0.74%	–
CYTK	Exit	CYTOKINETICS INC	$0	–	-208,800	–	-0.88%	–
EDAP	Exit	EDAP TMS SAsponsored adr	$0	–	-1,040,000	–	-0.94%	–
MEIP	Exit	MEI PHARMA INC	$0	–	-1,556,000	–	-0.95%	–
KALV	Exit	KALVISTA PHARMACEUTICALS INC	$0	–	-470,203	–	-1.15%	–
TELA	Exit	TELA BIO INC	$0	–	-362,074	–	-1.17%	–
FGEN	Exit	FIBROGEN INC	$0	–	-147,000	–	-1.18%	–
ADMS	Exit	ADAMAS PHARMACEUTICALS INC	$0	–	-1,487,800	–	-1.20%	–
BHVN	Exit	BIOHAVEN PHARMACEUTICAL HLDG	$0	–	-114,350	–	-1.45%	–
CERC	Exit	CERECOR INC	$0	–	-3,372,500	–	-1.50%	–
XOMA	Exit	XOMA CORP DEL	$0	–	-455,000	–	-1.68%	–
KNSA	Exit	KINIKSA PHARMACEUTICALS LTD	$0	–	-338,000	–	-1.72%	–
AXGT	Exit	AXOVANT SCIENCES LTD	$0	–	-2,039,100	–	-1.84%	–
MCRB	Exit	SERES THERAPEUTICS	$0	–	-335,312	–	-1.86%	–
CMRX	Exit	CHIMERIX INC	$0	–	-3,841,500	–	-1.87%	–
MYOV	Exit	MYOVANT SCIENCES LTD	$0	–	-682,500	–	-1.88%	–
FBIO	Exit	FORTRESS BIOTECH INC	$0	–	-3,830,000	–	-2.01%	–
TCON	Exit	TRACON PHARMACEUTICALS INC	$0	–	-2,013,438	–	-2.04%	–
TGTX	Exit	TG THERAPEUTICS INC	$0	–	-390,000	–	-2.04%	–
ATXI	Exit	AVENUE THERAPEUTICS INC	$0	–	-984,692	–	-2.09%	–
	Exit	APTOSE BIOSCIENCES INC	$0	–	-1,799,000	–	-2.11%	–
STXS	Exit	STEREOTAXIS INC	$0	–	-3,021,436	–	-2.12%	–
DCPH	Exit	DECIPHERA PHARMACEUTICALS IN	$0	–	-222,000	–	-2.23%	–
MGNX	Exit	MACROGENICS INC	$0	–	-527,000	–	-2.60%	–
CLDX	Exit	CELLDEX THERAPEUTICS INC	$0	–	-992,000	–	-2.88%	–
PCVX	Exit	VAXCYTE	$0	–	-313,000	–	-3.02%	–
EIDX	Exit	EIDOS THERAPEUTICS INC	$0	–	-315,550	–	-3.12%	–
CDXS	Exit	CODEXIS INC	$0	–	-1,400,000	–	-3.21%	–
HROW	Exit	HARROW HEALTH INC	$0	–	-2,959,000	–	-3.24%	–
NLTX	Exit	NEOLEUKIN THERAPEUTICS INC	$0	–	-1,386,300	–	-3.25%	–
CCXI	Exit	CHEMOCENTRYX INC	$0	–	-356,000	–	-3.82%	–
AFIB	Exit	ACUTUS MEDICAL INC	$0	–	-749,990	–	-4.37%	–
CRDF	Exit	CARDIFF ONCOLOGY INC	$0	–	-1,731,600	–	-4.80%	–
ETON	Exit	ETON PHARMACEUTICALS INC	$0	–	-3,640,000	–	-5.62%	–
TARA	Exit	PROTARA THERAPEUTICS INC	$0	–	-2,558,472	–	-8.42%	–
OCUL	Exit	OCULAR THERAPEUTIX INC	$0	–	-5,984,200	–	-8.91%	–

Q3 2020

			Value		Shares		↓ Weighting
TARA	Buy	PROTARA THERAPEUTICS INC	$43,059,000	-33.5%	2,558,472	+15.8%	8.42%	-35.6%
CRDF	Buy	CARDIFF ONCOLOGY INC	$24,571,000	+731.2%	1,731,600	+193.5%	4.80%	+704.9%
AFIB	New	ACUTUS MEDICAL INC	$22,350,000	–	749,990	–	4.37%	–
CCXI	Sell	CHEMOCENTRYX INC	$19,509,000	-6.3%	356,000	-1.5%	3.82%	-9.3%
NLTX	Sell	NEOLEUKIN THERAPEUTICS INC	$16,636,000	-28.4%	1,386,300	-1.0%	3.25%	-30.7%
HROW	Buy	HARROW HEALTH INC	$16,541,000	+17.2%	2,959,000	+9.2%	3.24%	+13.5%
PCVX	New	VAXCYTE	$15,456,000	–	313,000	–	3.02%	–
CLDX	Sell	CELLDEX THERAPEUTICS INC	$14,711,000	+5.7%	992,000	-7.4%	2.88%	+2.3%
MGNX	Buy	MACROGENICS INC	$13,275,000	-5.1%	527,000	+5.2%	2.60%	-8.1%
STXS	Sell	STEREOTAXIS INC	$10,817,000	-30.9%	3,021,436	-14.0%	2.12%	-33.1%
	Sell	APTOSE BIOSCIENCES INC	$10,794,000	-45.3%	1,799,000	-42.5%	2.11%	-47.1%
ATXI	Sell	AVENUE THERAPEUTICS INC	$10,664,000	-4.3%	984,692	-4.9%	2.09%	-7.3%
TGTX	Sell	TG THERAPEUTICS INC	$10,436,000	+17.3%	390,000	-14.6%	2.04%	+13.6%
TCON	New	TRACON PHARMACEUTICALS INC	$10,409,000	–	2,013,438	–	2.04%	–
CMRX	Buy	CHIMERIX INC	$9,565,000	+46.6%	3,841,500	+82.5%	1.87%	+42.0%
MCRB	New	SERES THERAPEUTICS	$9,493,000	–	335,312	–	1.86%	–
AXGT	New	AXOVANT SCIENCES LTD	$9,421,000	–	2,039,100	–	1.84%	–
KNSA	Sell	KINIKSA PHARMACEUTICALS LTD	$8,778,000	0.0%	338,000	-1.9%	1.72%	-3.2%
XOMA	Buy	XOMA CORP DEL	$8,572,000	+4.4%	455,000	+9.5%	1.68%	+1.1%
ADMS	Buy	ADAMAS PHARMACEUTICALS INC	$6,130,000	+149.4%	1,487,800	+55.0%	1.20%	+141.7%
FGEN	Buy	FIBROGEN INC	$6,045,000	+6.3%	147,000	+0.7%	1.18%	+2.9%
TELA	Buy	TELA BIO INC	$5,989,000	+84.8%	362,074	+44.8%	1.17%	+79.1%
KALV	Buy	KALVISTA PHARMACEUTICALS INC	$5,863,000	+5.0%	470,203	+1.9%	1.15%	+1.7%
EDAP	Sell	EDAP TMS SAsponsored adr	$4,784,000	+2.9%	1,040,000	-44.6%	0.94%	-0.3%
CYTK	Sell	CYTOKINETICS INC	$4,521,000	-36.7%	208,800	-31.1%	0.88%	-38.7%
CRNX	Sell	CRINETICS PHARMACEUTICALS INC	$3,761,000	-50.7%	240,000	-44.9%	0.74%	-52.2%
FULC	New	FULCRUM THERAPEUTICS INC	$3,584,000	–	452,000	–	0.70%	–
LUMO	New	LUMOS PHARMA INC	$3,329,000	–	240,892	–	0.65%	–
KZR	New	KEZAR LIFE SCIENCES INC	$3,282,000	–	678,000	–	0.64%	–
VSTM	New	VERASTEM INC	$3,201,000	–	2,200,000	–	0.63%	–
AGLE	New	AEGLEA BIOTHERAPEUTICS INC	$2,659,000	–	375,000	–	0.52%	–
NERV	New	MINERVA NEUROSCIENCES INC	$2,440,000	–	767,400	–	0.48%	–
OM	New	OUTSET MED INC	$2,250,000	–	45,000	–	0.44%	–
EPIX	Buy	ESSA PHARMA INC	$1,872,000	+72.5%	271,350	+55.1%	0.37%	+67.1%
STRO	New	SUTRO BIOPHARMA INC	$1,467,000	–	146,000	–	0.29%	–
CFRX	New	CONTRAFECT INC	$1,194,000	–	226,127	–	0.23%	–
CNCE	New	CONCERT PHARMACEUTICALS INC	$982,000	–	100,000	–	0.19%	–
AMRN	Sell	AMARIN CORP PLCsponsored adr new	$947,000	-69.9%	225,000	-50.5%	0.18%	-70.9%
XFOR	New	X4 PHARMACEUTICALS INC	$508,000	–	75,000	–	0.10%	–
ONCT	New	ONCTERNAL THERAPEUTICS INC	$331,000	–	194,541	–	0.06%	–
PIRS	New	PIERIS PHARMACEUTICALS INC	$300,000	–	145,000	–	0.06%	–
INFI	New	INFINITY PHARMACEUTICALS INC	$137,000	–	3,171,800	–	0.03%	–
MRUS	New	MERUS NV	$2,000	–	200	–	0.00%	–
MGTA	Exit	MAGENTA THERAPEUTICS INC	$0	–	-51,225	–	-0.08%	–
ASRT	Exit	ASSERTIO HOLDINGS INC	$0	–	-880,000	–	-0.15%	–
AUTL	Exit	AUTOLUS THERAPEUTICS PLCsponsored ads	$0	–	-60,000	–	-0.19%	–
FENC	Exit	FENNEC PHARMACEUTICALS INC	$0	–	-171,000	–	-0.29%	–
ARDX	Exit	ARDELYX INC	$0	–	-471,600	–	-0.66%	–
LQDA	Exit	LIQUIDIA TECHOLOGIES INC	$0	–	-400,000	–	-0.68%	–
KALA	Exit	KALA PHARMACEUTICALS INC	$0	–	-361,000	–	-0.77%	–
BTAI	Exit	BIOXCEL THERAPEUTICS INC	$0	–	-94,000	–	-1.01%	–
CPRX	Exit	CATALYST PHARMACEUTICALS INC	$0	–	-1,155,000	–	-1.08%	–
TCDA	Exit	TRICIDA INC	$0	–	-238,300	–	-1.32%	–
MTEM	Exit	MOLECULAR TEMPLATES INC	$0	–	-495,000	–	-1.38%	–
QURE	Exit	VAXCYTE	$0	–	-270,400	–	-1.73%	–
ODT	Exit	ODONATE THERAPEUTICS INC	$0	–	-250,000	–	-2.14%	–

Q2 2020

			Value		Shares		↓ Weighting
TARA	New	PROTARA THERAPEUTICS INC	$64,752,000	–	2,208,472	–	13.08%	–
OCUL	New	OCULAR THERAPEUTIX INC	$49,848,000	–	5,984,200	–	10.07%	–
NLTX	New	NEOLEUKIN THERAPEUTICS INC	$23,240,000	–	1,400,000	–	4.69%	–
CCXI	New	CHEMOCENTRYX INC	$20,816,000	–	361,600	–	4.20%	–
ETON	New	ETON PHARMACEUTICALS INC	$19,838,000	–	3,640,000	–	4.01%	–
	New	APTOSE BIOSCIENCES INC	$19,750,000	–	3,130,000	–	3.99%	–
CDXS	New	CODEXIS INC	$16,089,000	–	1,400,000	–	3.25%	–
STXS	New	STEREOTAXIS INC	$15,661,000	–	3,511,500	–	3.16%	–
EIDX	New	EIDOS THERAPEUTICS INC	$14,634,000	–	315,550	–	2.96%	–
HROW	New	HARROW HEALTH INC	$14,119,000	–	2,710,000	–	2.85%	–
MYOV	New	MYOVANT SCIENCES LTD	$14,073,000	–	682,500	–	2.84%	–
MGNX	New	MACROGENICS INC	$13,988,000	–	501,000	–	2.82%	–
CLDX	New	CELLDEX THERAPEUTICS INC	$13,923,000	–	1,071,000	–	2.81%	–
DCPH	New	DECIPHERA PHARMACEUTICALS IN	$13,081,000	–	222,000	–	2.64%	–
ATXI	New	AVENUE THERAPEUTICS INC	$11,147,000	–	1,035,000	–	2.25%	–
ODT	New	ODONATE THERAPEUTICS INC	$10,585,000	–	250,000	–	2.14%	–
FBIO	New	FORTRESS BIOTECH INC	$10,264,000	–	3,830,000	–	2.07%	–
TGTX	New	TG THERAPEUTICS INC	$8,895,000	–	456,600	–	1.80%	–
KNSA	New	KINIKSA PHARMACEUTICALS LTD	$8,778,000	–	344,500	–	1.77%	–
CERC	New	CERECOR INC	$8,768,000	–	3,372,500	–	1.77%	–
QURE	New	VAXCYTE	$8,547,000	–	270,400	–	1.73%	–
BHVN	New	BIOHAVEN PHARMACEUTICAL HLDG	$8,360,000	–	114,350	–	1.69%	–
XOMA	New	XOMA CORP DEL	$8,208,000	–	415,380	–	1.66%	–
CRNX	New	CRINETICS PHARMACEUTICALS INC	$7,625,000	–	435,200	–	1.54%	–
CYTK	New	CYTOKINETICS INC	$7,143,000	–	303,050	–	1.44%	–
MTEM	New	MOLECULAR TEMPLATES INC	$6,826,000	–	495,000	–	1.38%	–
TCDA	New	TRICIDA INC	$6,548,000	–	238,300	–	1.32%	–
CMRX	New	CHIMERIX INC	$6,526,000	–	2,105,000	–	1.32%	–
MEIP	New	MEI PHARMA INC	$6,426,000	–	1,556,000	–	1.30%	–
FGEN	New	FIBROGEN INC	$5,688,000	–	146,000	–	1.15%	–
KALV	New	KALVISTA PHARMACEUTICALS INC	$5,584,000	–	461,500	–	1.13%	–
CPRX	New	CATALYST PHARMACEUTICALS INC	$5,336,000	–	1,155,000	–	1.08%	–
BTAI	New	BIOXCEL THERAPEUTICS INC	$4,983,000	–	94,000	–	1.01%	–
EDAP	New	EDAP TMS SAsponsored adr	$4,648,000	–	1,878,500	–	0.94%	–
KALA	New	KALA PHARMACEUTICALS INC	$3,794,000	–	361,000	–	0.77%	–
CDTX	New	CIDARA THERAPEUTICS INC	$3,582,000	–	970,664	–	0.72%	–
LQDA	New	LIQUIDIA TECHOLOGIES INC	$3,368,000	–	400,000	–	0.68%	–
ARDX	New	ARDELYX INC	$3,263,000	–	471,600	–	0.66%	–
TELA	New	TELA BIO INC	$3,240,000	–	250,000	–	0.65%	–
AMRN	New	AMARIN CORP PLCsponsored adr	$3,149,000	–	455,000	–	0.64%	–
CRDF	New	CARDIFF ONCOLOGY INC	$2,956,000	–	590,000	–	0.60%	–
ADMS	New	ADAMAS PHARMACEUTICALS INC	$2,458,000	–	960,000	–	0.50%	–
FENC	New	FENNEC PHARMACEUTICALS INC	$1,428,000	–	171,000	–	0.29%	–
EPIX	New	ESSA PHARMA INC	$1,085,000	–	175,000	–	0.22%	–
AUTL	New	AUTOLUS THERAPEUTICS PLCsponsored ads	$962,000	–	60,000	–	0.19%	–
ASRT	New	ASSERTIO HOLDINGS INC	$754,000	–	880,000	–	0.15%	–
MGTA	New	MAGENTA THERAPEUTICS INC	$385,000	–	51,225	–	0.08%	–
BLRX	New	BIOLINERX LTDsponsored ads	$29,000	–	16,667	–	0.01%	–

Q4 2019

			Value		Shares		↓ Weighting
PRTO	Exit	PROTEON THERAPEUTICS INC	$0	–	-54,000	–	-0.01%	–
BLRX	Exit	BIOLINERX LTDsponsored adr	$0	–	-16,667	–	-0.02%	–
ASMB	Exit	ASSEMBLY BIOSCIENCES INC	$0	–	-50,000	–	-0.18%	–
VRML	Exit	VERMILLION INC	$0	–	-1,265,000	–	-0.24%	–
CBAY	Exit	CYMABAY THERAPEUTICS INC	$0	–	-140,000	–	-0.26%	–
SBBP	Exit	STRONGBRIDGE BIOPHARMA PLC	$0	–	-490,000	–	-0.42%	–
ITCI	Exit	INTRA CELLULAR THERAPIES INC	$0	–	-170,000	–	-0.46%	–
EDAP	Exit	EDAP TMS SAsponsored adr	$0	–	-300,000	–	-0.49%	–
CCXI	Exit	CHEMOCENTRYX INC	$0	–	-200,000	–	-0.49%	–
FLXN	Exit	FLEXION THERAPEUTICS INC	$0	–	-105,000	–	-0.52%	–
	Exit	APTOSE BIOSCIENCES INC	$0	–	-720,000	–	-0.54%	–
RDUS	Exit	RADIUS HEALTH INC	$0	–	-75,000	–	-0.70%	–
	Exit	FORTRESS BIOTECH INC	$0	–	-1,655,000	–	-0.84%	–
NXTC	Exit	NEXTCURE INC	$0	–	-85,000	–	-0.95%	–
FTSV	Exit	FORTY SEVEN INC	$0	–	-425,000	–	-0.99%	–
NLTX	Exit	NEOLEUKIN THERAPEUTICS INC	$0	–	-995,000	–	-1.03%	–
THOR	Exit	SYNTHORX INC	$0	–	-180,000	–	-1.06%	–
CRNX	Exit	CRINETICS PHARMACEUTICALS INC	$0	–	-207,000	–	-1.13%	–
RARX	Exit	RA PHARMACEUTICALS INC	$0	–	-141,800	–	-1.21%	–
TGTX	Exit	TG THERAPEUTICS INC	$0	–	-612,500	–	-1.24%	–
MGTA	Exit	MAGENTA THERAPEUTICS INC	$0	–	-385,000	–	-1.43%	–
QTRX	Exit	QUANTERIX CORP	$0	–	-185,000	–	-1.47%	–
ZYME	Exit	ZYMEWORKS INC	$0	–	-170,000	–	-1.52%	–
SWAV	Exit	SHOCKWAVE MED INC	$0	–	-160,000	–	-1.73%	–
FGEN	Exit	FIBROGEN INC	$0	–	-150,000	–	-2.01%	–
ATXI	Exit	AVENUE THERAPEUTICS INC	$0	–	-952,600	–	-2.05%	–
TCDA	Exit	TRICIDA INC	$0	–	-195,000	–	-2.18%	–
PTCT	Exit	PTC THERAPEUTICS INC	$0	–	-190,000	–	-2.32%	–
BHVN	Exit	BIOHAVEN PHARMACEUTICAL HLDG	$0	–	-160,000	–	-2.41%	–
CERC	Exit	CERECOR INC	$0	–	-2,185,536	–	-2.60%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INC	$0	–	-200,000	–	-2.60%	–
ETON	Exit	ETON PHARMACEUTICALS INC	$0	–	-1,165,000	–	-2.66%	–
XOMA	Exit	XOMA CORP DEL	$0	–	-375,000	–	-2.67%	–
	Exit	CYTOKINETICS	$0	–	-650,000	–	-2.68%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-105,000	–	-2.79%	–
DCPH	Exit	DECIPHERA PHARMACEUTICALS IN	$0	–	-230,000	–	-2.82%	–
BOLD	Exit	AUDENTES THERAPEUTICS INC	$0	–	-285,000	–	-2.90%	–
CARA	Exit	CARA THERAPEUTICS INC	$0	–	-440,000	–	-2.91%	–
QURE	Exit	UNIQURE NV	$0	–	-205,000	–	-2.92%	–
AXGN	Exit	AXOGEN INC	$0	–	-700,000	–	-3.03%	–
OCUL	Exit	OCULAR THERAPEUTIX INC	$0	–	-2,775,000	–	-3.05%	–
ODT	Exit	ODONATE THERAPEUTICS INC	$0	–	-350,000	–	-3.30%	–
AMRN	Exit	AMARIN CORP PLCsponsored adr	$0	–	-645,000	–	-3.54%	–
TPTX	Exit	TURNING POINT THERAPEUTICS INC	$0	–	-287,500	–	-3.91%	–
EIDX	Exit	EIDOS THERAPEUTICS INC	$0	–	-305,550	–	-3.97%	–
IMMY	Exit	HARROW HEALTH	$0	–	-2,370,000	–	-4.82%	–
EPZM	Exit	EPIZYME INC	$0	–	-1,365,000	–	-5.09%	–
STXS	Exit	STEREOTAXIS INC	$0	–	-4,070,000	–	-5.17%	–
CDXS	Exit	CODEXIS INC	$0	–	-1,350,000	–	-6.70%	–

Q3 2019

			Value		Shares		↓ Weighting
STXS	New	STEREOTAXIS INC	$14,286,000	–	4,070,000	–	5.17%	–
IMMY	Buy	HARROW HEALTH	$13,319,000	-30.7%	2,370,000	+7.2%	4.82%	-17.8%
TPTX	New	TURNING POINT THERAPEUTICS INC	$10,810,000	–	287,500	–	3.91%	–
ODT	Sell	ODONATE THERAPEUTICS INC	$9,111,000	-41.6%	350,000	-17.6%	3.30%	-30.7%
OCUL	Sell	OCULAR THERAPEUTIX INC	$8,436,000	-35.0%	2,775,000	-5.9%	3.05%	-22.9%
AXGN	Sell	AXOGEN INC	$8,376,000	-53.0%	700,000	-22.2%	3.03%	-44.2%
CARA	New	CARA THERAPEUTICS INC	$8,043,000	–	440,000	–	2.91%	–
BOLD	Buy	AUDENTES THERAPEUTICS INC	$8,006,000	-24.5%	285,000	+1.8%	2.90%	-10.4%
DCPH	Sell	DECIPHERA PHARMACEUTICALS IN	$7,806,000	+11.7%	230,000	-25.8%	2.82%	+32.5%
BPMC	Sell	BLUEPRINT MEDICINES CORP	$7,714,000	-34.6%	105,000	-16.0%	2.79%	-22.4%
	Sell	CYTOKINETICS	$7,397,000	-26.9%	650,000	-27.8%	2.68%	-13.3%
XOMA	Sell	XOMA CORP DEL	$7,391,000	+24.3%	375,000	-6.2%	2.67%	+47.5%
ETON	Buy	ETON PHARMACEUTICALS INC	$7,363,000	-13.3%	1,165,000	+8.4%	2.66%	+2.9%
BHVN	Buy	BIOHAVEN PHARMACEUTICAL HLDG	$6,675,000	+1.6%	160,000	+6.7%	2.41%	+20.6%
PTCT	Sell	PTC THERAPEUTICS INC	$6,426,000	-36.9%	190,000	-16.1%	2.32%	-25.2%
ATXI	Buy	AVENUE THERAPEUTICS INC	$5,677,000	-3.1%	952,600	+2.4%	2.05%	+14.9%
SWAV	New	SHOCKWAVE MED INC	$4,789,000	–	160,000	–	1.73%	–
QTRX	New	QUANTERIX CORP	$4,063,000	–	185,000	–	1.47%	–
MGTA	Sell	MAGENTA THERAPEUTICS INC	$3,950,000	-49.9%	385,000	-28.0%	1.43%	-40.6%
TGTX	Sell	TG THERAPEUTICS INC	$3,439,000	-65.4%	612,500	-46.7%	1.24%	-59.0%
RARX	Buy	RA PHARMACEUTICALS INC	$3,354,000	+118.6%	141,800	+178.0%	1.21%	+159.2%
CRNX	Buy	CRINETICS PHARMACEUTICALS INC	$3,113,000	+245.9%	207,000	+475.0%	1.13%	+310.9%
THOR	Buy	SYNTHORX INC	$2,929,000	+37.6%	180,000	+14.2%	1.06%	+63.2%
NLTX	New	NEOLEUKIN THERAPEUTICS INC	$2,836,000	–	995,000	–	1.03%	–
FTSV	New	FORTY SEVEN INC	$2,729,000	–	425,000	–	0.99%	–
NXTC	New	NEXTCURE INC	$2,622,000	–	85,000	–	0.95%	–
	Sell	FORTRESS BIOTECH INC	$2,334,000	-34.2%	1,655,000	-30.0%	0.84%	-21.9%
RDUS	New	RADIUS HEALTH INC	$1,931,000	–	75,000	–	0.70%	–
	New	APTOSE BIOSCIENCES INC	$1,501,000	–	720,000	–	0.54%	–
FLXN	New	FLEXION THERAPEUTICS INC	$1,439,000	–	105,000	–	0.52%	–
CCXI	New	CHEMOCENTRYX INC	$1,356,000	–	200,000	–	0.49%	–
EDAP	New	EDAP TMS SAsponsored adr	$1,347,000	–	300,000	–	0.49%	–
ITCI	New	INTRA CELLULAR THERAPIES INC	$1,270,000	–	170,000	–	0.46%	–
SBBP	Sell	STRONGBRIDGE BIOPHARMA PLC	$1,171,000	-67.2%	490,000	-57.0%	0.42%	-61.1%
CBAY	New	CYMABAY THERAPEUTICS INC	$717,000	–	140,000	–	0.26%	–
VRML	Sell	VERMILLION INC	$661,000	-82.5%	1,265,000	-70.2%	0.24%	-79.3%
ASMB	New	ASSEMBLY BIOSCIENCES INC	$492,000	–	50,000	–	0.18%	–
BLRX	Sell	BIOLINERX LTDsponsored adr	$44,000	-51.6%	16,667	-93.3%	0.02%	-42.9%
PRTO	New	PROTEON THERAPEUTICS INC	$14,000	–	54,000	–	0.01%	–
AZRX	Exit	AZURRX BIOPHARMA INC	$0	–	-145,000	–	-0.08%	–
PLX	Exit	PROTALIX BIOTHERAPEUTICS INC	$0	–	-1,000,000	–	-0.14%	–
ARQL	Exit	ARQULE INC	$0	–	-100,000	–	-0.34%	–
FENC	Exit	FENNEC PHARMACEUTICALS INC	$0	–	-295,000	–	-0.36%	–
AQST	Exit	AQUESTIVE THERAPEUTICS INC	$0	–	-590,000	–	-0.76%	–
AIMT	Exit	AIMMUNE THERAPEUTICS INC	$0	–	-130,000	–	-0.82%	–
VKTX	Exit	VIKING THERAPEUTICS INC	$0	–	-400,000	–	-1.01%	–
ARVN	Exit	ARVINAS INC	$0	–	-220,000	–	-1.48%	–
IRWD	Exit	IRONWOOD PHARMACEUTICAL INC	$0	–	-525,400	–	-1.75%	–
CMRX	Exit	CHIMERIX INC	$0	–	-1,470,000	–	-1.94%	–
LXRX	Exit	LEXICON PHARMACEUTICALS INC	$0	–	-1,480,000	–	-2.84%	–

Q2 2019

			Value		Shares		↓ Weighting
CDXS	New	CODEXIS INC	$24,881,000	–	1,350,000	–	7.58%	–
IMMY	New	HARROW HEALTH	$19,227,000	–	2,210,000	–	5.86%	–
AXGN	New	AXOGEN INC	$17,820,000	–	900,000	–	5.43%	–
EPZM	New	EPIZYME INC	$17,131,000	–	1,365,000	–	5.22%	–
QURE	New	UNIQURE NV	$16,021,000	–	205,000	–	4.88%	–
ODT	New	ODONATE THERAPEUTICS INC	$15,593,000	–	425,000	–	4.75%	–
OCUL	New	OCULAR THERAPEUTIX INC	$12,980,000	–	2,950,000	–	3.96%	–
AMRN	New	AMARIN CORP PLCsponsored adr	$12,507,000	–	645,000	–	3.81%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$11,791,000	–	125,000	–	3.59%	–
CERC	New	CERECOR INC	$11,176,000	–	2,185,536	–	3.41%	–
BOLD	New	AUDENTES THERAPEUTICS INC	$10,601,000	–	280,000	–	3.23%	–
PTCT	New	PTC THERAPEUTICS INC	$10,187,000	–	226,388	–	3.10%	–
	New	CYTOKINETICS	$10,125,000	–	900,000	–	3.09%	–
TGTX	New	TG THERAPEUTICS INC	$9,948,000	–	1,150,000	–	3.03%	–
EIDX	New	EIDOS THERAPEUTICS INC	$9,496,000	–	305,550	–	2.89%	–
LXRX	New	LEXICON PHARMACEUTICALS INC	$9,309,000	–	1,480,000	–	2.84%	–
ETON	New	ETON PHARMACEUTICALS INC	$8,493,000	–	1,075,000	–	2.59%	–
MGTA	New	MAGENTA THERAPEUTICS INC	$7,891,000	–	535,000	–	2.40%	–
TCDA	New	TRICIDA INC	$7,695,000	–	195,000	–	2.34%	–
DCPH	New	DECIPHERA PHARMACEUTICALS IN	$6,991,000	–	310,000	–	2.13%	–
FGEN	New	FIBROGEN INC	$6,777,000	–	150,000	–	2.07%	–
BHVN	New	BIOHAVEN PHARMACEUTICAL HLDG	$6,569,000	–	150,000	–	2.00%	–
CMRX	New	CHIMERIX INC	$6,350,000	–	1,470,000	–	1.94%	–
XOMA	New	XOMA CORP DEL	$5,944,000	–	400,000	–	1.81%	–
ATXI	New	AVENUE THERAPEUTICS INC	$5,859,000	–	930,000	–	1.79%	–
IRWD	New	IRONWOOD PHARMACEUTICAL INC	$5,748,000	–	525,400	–	1.75%	–
ACAD	New	ACADIA PHARMACEUTICALS INC	$5,346,000	–	200,000	–	1.63%	–
ARVN	New	ARVINAS INC	$4,838,000	–	220,000	–	1.48%	–
VRML	New	VERMILLION INC	$3,783,000	–	4,250,000	–	1.15%	–
ZYME	New	ZYMEWORKS INC	$3,744,000	–	170,000	–	1.14%	–
SBBP	New	STRONGBRIDGE BIOPHARMA PLC	$3,568,000	–	1,140,000	–	1.09%	–
	New	FORTRESS BIOTECH INC	$3,548,000	–	2,365,000	–	1.08%	–
VKTX	New	VIKING THERAPEUTICS INC	$3,320,000	–	400,000	–	1.01%	–
AIMT	New	AIMMUNE THERAPEUTICS INC	$2,708,000	–	130,000	–	0.82%	–
AQST	New	AQUESTIVE THERAPEUTICS INC	$2,478,000	–	590,000	–	0.76%	–
THOR	New	SYNTHORX INC	$2,129,000	–	157,600	–	0.65%	–
RARX	New	RA PHARMACEUTICALS INC	$1,534,000	–	51,000	–	0.47%	–
FENC	New	FENNEC PHARMACEUTICALS INC	$1,180,000	–	295,000	–	0.36%	–
ARQL	New	ARQULE INC	$1,101,000	–	100,000	–	0.34%	–
CRNX	New	CRINETICS PHARMACEUTICALS INC	$900,000	–	36,000	–	0.27%	–
PLX	New	PROTALIX BIOTHERAPEUTICS INC	$469,000	–	1,000,000	–	0.14%	–
AZRX	New	AZURRX BIOPHARMA INC	$247,000	–	145,000	–	0.08%	–
BLRX	New	BIOLINERX LTD (Does not reflect a reverse stock split effectuated after June 30, 2019)sponsored adr	$91,000	–	250,000	–	0.03%	–

Q4 2018

			Value		Shares		↓ Weighting
BLRX	Exit	BIOLINERX LTDsponsored adr	$0	–	-250,000	–	-0.07%	–
FOMX	Exit	FOAMIX LTD	$0	–	-91,000	–	-0.13%	–
INFI	Exit	INFINITY PHARMACEUTICALS INC	$0	–	-275,000	–	-0.19%	–
ACHN	Exit	ACHILLION PHARMACEUTICALS INC	$0	–	-275,000	–	-0.26%	–
DERM	Exit	DERMIRA INC	$0	–	-97,400	–	-0.27%	–
BFRA	Exit	BIOFRONTERA AGsponsored adr	$0	–	-79,007	–	-0.27%	–
TCDA	Exit	TRICIDA INC	$0	–	-51,000	–	-0.40%	–
CMTA	Exit	CLEMENTIA PHARMACEUTICAL INC	$0	–	-148,832	–	-0.42%	–
PLX	Exit	PROTALIX BIOTHERAPEUTICS INC	$0	–	-2,500,000	–	-0.46%	–
TGTX	Exit	TG THERAPEUTICS INC	$0	–	-350,000	–	-0.50%	–
EPZM	Exit	EPIZYME INC	$0	–	-200,000	–	-0.54%	–
ARDX	Exit	ARDELYX INC	$0	–	-650,000	–	-0.72%	–
CLLS	Exit	CELLECTIS SAsponsored ads	$0	–	-110,000	–	-0.79%	–
ARQL	Exit	ARQULE INC	$0	–	-550,000	–	-0.79%	–
CARA	Exit	CARA THERAPEUTICS INC	$0	–	-130,000	–	-0.79%	–
CTIC	Exit	CTI BIOPHARMA CORP	$0	–	-1,550,000	–	-0.85%	–
IOVA	Exit	IOVANCE BIOTHERAPEUTICS INC	$0	–	-325,000	–	-0.93%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INC	$0	–	-195,000	–	-1.03%	–
IMMY	Exit	IMPRIMIS PHARMACEUTICALS	$0	–	-1,620,000	–	-1.15%	–
CMRX	Exit	CHIMERIX INC	$0	–	-1,185,000	–	-1.17%	–
CORI	Exit	CORIUM INTERNATIONAL INC	$0	–	-550,000	–	-1.33%	–
CDTX	Exit	CIDARA THERAPEUTICS INC	$0	–	-1,200,000	–	-1.34%	–
OCUL	Exit	OCULAR THERAPEUTIX INC	$0	–	-800,000	–	-1.40%	–
XOMA	Exit	XOMA CORP DEL	$0	–	-320,000	–	-1.43%	–
RARE	Exit	ULTRAGENYX PHARMACEUTICALS INC	$0	–	-80,000	–	-1.55%	–
XNCR	Exit	XENCOR INC	$0	–	-180,000	–	-1.56%	–
APLS	Exit	APELLIS PHARMACEUTICALS INC	$0	–	-375,000	–	-1.70%	–
XENE	Exit	XENON PHARMACEUTICALS INC	$0	–	-465,200	–	-1.78%	–
CBAY	Exit	CYMABAY THERAPEUTICS INC	$0	–	-698,100	–	-1.97%	–
MGEN	Exit	MIRAGEN THERAPEUTICS INC	$0	–	-1,395,700	–	-1.98%	–
FENC	Exit	FENNEC PHARMACEUTICALS INC	$0	–	-975,000	–	-2.03%	–
SGMO	Exit	SANGAMO BIOSCIENCES INC	$0	–	-490,000	–	-2.11%	–
SBBP	Exit	STRONGBRIDGE BIOPHARMA PLC	$0	–	-1,730,000	–	-2.14%	–
AMAG	Exit	AMAG PHARMACEUTICALS INC	$0	–	-420,000	–	-2.14%	–
PTCT	Exit	PTC THERAPEUTICS INC	$0	–	-180,000	–	-2.15%	–
MGTA	Exit	MAGENTA THERAPEUTICS INC	$0	–	-725,000	–	-2.22%	–
BOLD	Exit	AUDENTES THERAPEUTICS INC	$0	–	-225,000	–	-2.27%	–
AGIO	Exit	AGIOS PHARMACEUTICALS	$0	–	-130,000	–	-2.55%	–
FGEN	Exit	FIBROGEN INC	$0	–	-200,000	–	-3.09%	–
VKTX	Exit	VIKING THERAPEUTICS INC	$0	–	-825,000	–	-3.66%	–
PTE	Exit	POLARITYTE INC	$0	–	-765,000	–	-3.72%	–
DCPH	Exit	DECIPHERA PHARMACEUTICALS IN	$0	–	-420,000	–	-4.14%	–
BPMC	Exit	BLUEPRINT MEDICINES	$0	–	-300,000	–	-5.96%	–
AMRN	Exit	AMARIN CORP PLCsponsored adr	$0	–	-1,600,000	–	-6.62%	–
LOXO	Exit	LOXO ONCOLOGY	$0	–	-175,000	–	-7.61%	–
CDXS	Exit	CODEXIS INC	$0	–	-1,750,000	–	-7.64%	–
AXGN	Exit	AXOGEN INC	$0	–	-1,300,000	–	-12.19%	–

Q3 2018

			Value		Shares		↓ Weighting
AXGN	Sell	AXOGEN INC	$47,905,000	-33.8%	1,300,000	-9.7%	12.19%	-34.9%
AMRN	Sell	AMARIN CORP PLCsponsored adr	$26,032,000	+381.4%	1,600,000	-8.6%	6.62%	+373.4%
BPMC	Sell	BLUEPRINT MEDICINES	$23,418,000	+5.4%	300,000	-14.3%	5.96%	+3.6%
PTE	Sell	POLARITYTE INC	$14,611,000	-22.4%	765,000	-4.4%	3.72%	-23.7%
VKTX	Sell	VIKING THERAPEUTICS INC	$14,371,000	+26.2%	825,000	-31.2%	3.66%	+24.0%
FGEN	Sell	FIBROGEN INC	$12,150,000	-46.1%	200,000	-44.4%	3.09%	-47.0%
BOLD	Buy	AUDENTES THERAPEUTICS INC	$8,907,000	+22.7%	225,000	+18.4%	2.27%	+20.6%
MGTA	Buy	MAGENTA THERAPEUTICS INC	$8,707,000	+17.3%	725,000	+31.8%	2.22%	+15.2%
SBBP	Sell	STRONGBRIDGE BIOPHARMA PLC	$8,390,000	-23.6%	1,730,000	-5.5%	2.14%	-24.9%
SGMO	Sell	SANGAMO BIOSCIENCES INC	$8,305,000	+15.8%	490,000	-3.0%	2.11%	+13.8%
FENC	Buy	FENNEC PHARMACEUTICALS INC	$7,995,000	-19.0%	975,000	+3.2%	2.03%	-20.3%
MGEN	Buy	MIRAGEN THERAPEUTICS INC	$7,788,000	+1.2%	1,395,700	+16.3%	1.98%	-0.5%
CBAY	Buy	CYMABAY THERAPEUTICS INC	$7,735,000	-17.4%	698,100	+0.1%	1.97%	-18.8%
XENE	New	XENON PHARMACEUTICALS INC	$7,014,000	–	465,200	–	1.78%	–
APLS	Buy	APELLIS PHARMACEUTICALS INC	$6,667,000	+14.4%	375,000	+41.5%	1.70%	+12.4%
XOMA	Sell	XOMA CORP DEL	$5,622,000	-15.9%	320,000	-0.1%	1.43%	-17.3%
OCUL	Sell	OCULAR THERAPEUTIX INC	$5,504,000	-26.6%	800,000	-28.0%	1.40%	-27.9%
CORI	Sell	CORIUM INTERNATIONAL INC	$5,230,000	-18.4%	550,000	-31.2%	1.33%	-19.8%
CMRX	Buy	CHIMERIX INC	$4,609,000	-15.8%	1,185,000	+3.0%	1.17%	-17.2%
IMMY	New	IMPRIMIS PHARMACEUTICALS	$4,503,000	–	1,620,000	–	1.15%	–
ACAD	New	ACADIA PHARMACEUTICALS INC	$4,048,000	–	195,000	–	1.03%	–
IOVA	New	IOVANCE BIOTHERAPEUTICS INC	$3,656,000	–	325,000	–	0.93%	–
CTIC	Buy	CTI BIOPHARMA CORP	$3,348,000	+316.9%	1,550,000	+860.3%	0.85%	+309.6%
CARA	New	CARA THERAPEUTICS INC	$3,113,000	–	130,000	–	0.79%	–
ARQL	Buy	ARQULE INC	$3,113,000	+34.1%	550,000	+31.0%	0.79%	+31.8%
CLLS	New	CELLECTIS SAsponsored ads	$3,104,000	–	110,000	–	0.79%	–
ARDX	New	ARDELYX INC	$2,827,000	–	650,000	–	0.72%	–
EPZM	Sell	EPIZYME INC	$2,120,000	-43.1%	200,000	-27.3%	0.54%	-44.1%
TGTX	Sell	TG THERAPEUTICS INC	$1,960,000	-76.1%	350,000	-44.0%	0.50%	-76.5%
PLX	Sell	PROTALIX BIOTHERAPEUTICS INC	$1,817,000	+36.3%	2,500,000	-19.4%	0.46%	+33.9%
CMTA	New	CLEMENTIA PHARMACEUTICAL INC	$1,660,000	–	148,832	–	0.42%	–
TCDA	New	TRICIDA INC	$1,558,000	–	51,000	–	0.40%	–
BFRA	Sell	BIOFRONTERA AGsponsored adr	$1,073,000	-77.4%	79,007	-79.8%	0.27%	-77.8%
DERM	New	DERMIRA INC	$1,061,000	–	97,400	–	0.27%	–
ACHN	New	ACHILLION PHARMACEUTICALS INC	$1,012,000	–	275,000	–	0.26%	–
INFI	New	INFINITY PHARMACEUTICALS INC	$745,000	–	275,000	–	0.19%	–
FOMX	Sell	FOAMIX LTD	$521,000	-86.4%	91,000	-63.6%	0.13%	-86.6%
AZRX	Exit	AZURRX BIOPHARMA INC	$0	–	-130,000	–	-0.11%	–

Q2 2018

			Value		Shares		↓ Weighting
AXGN	New	AXOGEN INC	$72,360,000	–	1,440,000	–	18.73%	–
LOXO	New	LOXO ONCOLOGY	$30,359,000	–	175,000	–	7.86%	–
CDXS	New	CODEXIS INC	$25,200,000	–	1,750,000	–	6.52%	–
FGEN	New	FIBROGEN INC	$22,536,000	–	360,000	–	5.83%	–
BPMC	New	BLUEPRINT MEDICINES	$22,218,000	–	350,000	–	5.75%	–
PTE	New	POLARITYTE INC	$18,832,000	–	800,000	–	4.87%	–
DCPH	New	DECIPHERA PHARMACEUTICALS IN	$16,527,000	–	420,000	–	4.28%	–
VKTX	New	VIKING THERAPEUTICS INC	$11,388,000	–	1,200,000	–	2.95%	–
SBBP	New	STRONGBRIDGE BIOPHARMA PLC	$10,980,000	–	1,830,000	–	2.84%	–
AGIO	New	AGIOS PHARMACEUTICALS	$10,949,000	–	130,000	–	2.83%	–
FENC	New	FENNEC PHARMACEUTICALS INC	$9,865,000	–	945,000	–	2.55%	–
CBAY	New	CYMABAY THERAPEUTICS INC	$9,360,000	–	697,500	–	2.42%	–
TGTX	New	TG THERAPEUTICS INC	$8,218,000	–	625,000	–	2.13%	–
AMAG	New	AMAG PHARMACEUTICALS INC	$8,190,000	–	420,000	–	2.12%	–
MGEN	New	MIRAGEN THERAPEUTICS INC	$7,692,000	–	1,200,000	–	1.99%	–
OCUL	New	OCULAR THERAPEUTIX INC	$7,499,000	–	1,111,000	–	1.94%	–
MGTA	New	MAGENTA THERAPEUTICS INC	$7,425,000	–	550,000	–	1.92%	–
BOLD	New	AUDENTES THERAPEUTICS INC	$7,259,000	–	190,000	–	1.88%	–
SGMO	New	SANGAMO BIOSCIENCES INC	$7,171,000	–	505,000	–	1.86%	–
XOMA	New	XOMA CORP DEL	$6,685,000	–	320,200	–	1.73%	–
XNCR	New	XENCOR INC	$6,661,000	–	180,000	–	1.72%	–
CORI	New	CORIUM INTERNATIONAL INC	$6,408,000	–	800,000	–	1.66%	–
CDTX	New	CIDARA THERAPEUTICS INC	$6,240,000	–	1,200,000	–	1.62%	–
RARE	New	ULTRAGENYX PHARMACEUTICALS INC	$6,149,000	–	80,000	–	1.59%	–
PTCT	New	PTC THERAPEUTICS INC	$6,071,000	–	180,000	–	1.57%	–
APLS	New	APELLIS PHARMACEUTICALS INC	$5,830,000	–	265,000	–	1.51%	–
CMRX	New	CHIMERIX INC	$5,474,000	–	1,150,000	–	1.42%	–
AMRN	New	AMARIN CORP PLCsponsored adr	$5,407,000	–	1,750,000	–	1.40%	–
BFRA	New	BIOFRONTERA AGsponsored adr	$4,755,000	–	391,400	–	1.23%	–
FOMX	New	GTX INC	$3,827,000	–	250,000	–	0.99%	–
EPZM	New	EPIZYME INC	$3,726,000	–	275,000	–	0.96%	–
ARQL	New	ARQULE INC	$2,322,000	–	420,000	–	0.60%	–
PLX	New	PROTALIX BIOTHERAPEUTICS INC	$1,333,000	–	3,100,000	–	0.34%	–
CTIC	New	CTI BIOPHARMA CORP	$803,000	–	161,400	–	0.21%	–
AZRX	New	AZURRX BIOPHARMA INC	$417,000	–	130,000	–	0.11%	–
BLRX	New	BIOLINERX LTDsponsored adr	$222,000	–	250,000	–	0.06%	–

Q4 2017

			Value		Shares		↓ Weighting
BLRX	Exit	BIOLINERX LTDsponsored adr	$0	–	-250,000	–	-0.10%	–
QUOT	Exit	QUOTIENT TECHNOLOGY INC	$0	–	-110,000	–	-0.19%	–
ARQL	Exit	ARQULE INC	$0	–	-1,220,000	–	-0.48%	–
ICPT	Exit	INTERCEPT PHARMACEUTICALS INC	$0	–	-28,400	–	-0.58%	–
SYRS	Exit	SYROS PHARMACEUTICALS INC	$0	–	-116,574	–	-0.61%	–
SELB	Exit	SELECTA BIOSCIENCES INC	$0	–	-95,000	–	-0.61%	–
PETX	Exit	ARATANA THERAPEUTICS INC	$0	–	-420,000	–	-0.91%	–
	Exit	NEURODERM LTD	$0	–	-70,000	–	-0.96%	–
ITEK	Exit	INOTEK PHARMACEUTICALS CORP	$0	–	-1,802,000	–	-1.13%	–
INSM	Exit	INSMED INC	$0	–	-120,000	–	-1.32%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-101,500	–	-1.34%	–
ARDX	Exit	ARDELYX	$0	–	-700,000	–	-1.39%	–
DCPH	Exit	DECIPHERA PHARMACEUTICALS INC	$0	–	-217,000	–	-1.46%	–
ENTA	Exit	ENANTA PHARMACEUTICALS INC	$0	–	-100,000	–	-1.66%	–
SYBX	Exit	SYNLOGIC INC	$0	–	-250,000	–	-1.68%	–
BOLD	Exit	AUDENTES THERAPEUTICS INC	$0	–	-180,000	–	-1.78%	–
CBAY	Exit	CYMABAY THERAPEUTICS INC	$0	–	-665,000	–	-1.89%	–
TBPH	Exit	THERAVANCE BIOPHARMA INC	$0	–	-180,000	–	-2.18%	–
XOMA	Exit	XOMA CORP DEL	$0	–	-320,200	–	-2.22%	–
FOMX	Exit	FOAMIX PHARMACEUTICALS LTD	$0	–	-1,142,000	–	-2.24%	–
CMRX	Exit	CHIMERIX INC	$0	–	-1,403,000	–	-2.60%	–
EGRX	Exit	EAGLE PHARMACEUTICALS INC	$0	–	-130,000	–	-2.74%	–
SBBP	Exit	STRONGBRIDGE BIOPHARMA PLC	$0	–	-1,180,000	–	-2.88%	–
CTMX	Exit	CYTOMX THERAPEUTICS INC	$0	–	-450,000	–	-2.89%	–
AGIO	Exit	AGIOS PHARMACEUTICALS	$0	–	-130,000	–	-3.07%	–
SGMO	Exit	SANGAMO BIOSCIENCES INC	$0	–	-580,000	–	-3.08%	–
MNTA	Exit	MOMENTA PHARMACEUTICALS INC	$0	–	-500,000	–	-3.27%	–
CORI	Exit	CORIUM INTERNATIONAL INC	$0	–	-920,000	–	-3.60%	–
CDXS	Exit	CODEXIS INC	$0	–	-1,700,600	–	-4.00%	–
LOXO	Exit	LOXO ONCOLOGY	$0	–	-130,000	–	-4.24%	–
IMMU	Exit	IMMUNOMEDICS INC	$0	–	-898,800	–	-4.44%	–
FGEN	Exit	FIBROGEN INC	$0	–	-360,000	–	-6.85%	–
AXGN	Exit	AXOGEN INC	$0	–	-1,970,000	–	-13.48%	–
BPMC	Exit	BLUEPRINT MEDICINES	$0	–	-735,000	–	-18.11%	–

Q3 2017

			Value		Shares		↓ Weighting
BPMC	Sell	BLUEPRINT MEDICINES	$51,207,000	+14.8%	735,000	-16.5%	18.11%	-2.8%
IMMU	Sell	IMMUNOMEDICS INC	$12,565,000	+58.1%	898,800	-0.1%	4.44%	+33.9%
CDXS	Buy	CODEXIS INC	$11,309,000	+41.2%	1,700,600	+15.7%	4.00%	+19.5%
CORI	Buy	CORIUM INTERNATIONAL INC	$10,193,000	+91.1%	920,000	+28.7%	3.60%	+61.8%
MNTA	Buy	MOMENTA PHARMACEUTICALS INC	$9,250,000	+21.6%	500,000	+11.1%	3.27%	+3.0%
CTMX	Sell	CYTOMX THERAPEUTICS INC	$8,176,000	+14.7%	450,000	-2.2%	2.89%	-2.9%
EGRX	Buy	EAGLE PHARMACEUTICALS INC	$7,753,000	+63.8%	130,000	+116.7%	2.74%	+38.7%
CMRX	Buy	CHIMERIX INC	$7,365,000	+5.6%	1,403,000	+9.6%	2.60%	-10.6%
FOMX	Buy	FOAMIX PHARMACEUTICALS LTD	$6,338,000	+20.4%	1,142,000	+0.6%	2.24%	+1.9%
XOMA	Buy	XOMA CORP DEL	$6,292,000	+183.8%	320,200	+0.9%	2.22%	+140.3%
CBAY	New	CYMABAY THERAPEUTICS INC	$5,356,000	–	665,000	–	1.89%	–
BOLD	Buy	AUDENTES THERAPEUTICS INC	$5,041,000	+75.7%	180,000	+20.0%	1.78%	+48.8%
SYBX	New	SYNLOGIC INC	$4,753,000	–	250,000	–	1.68%	–
DCPH	New	DECIPHERA PHARMACEUTICALS INC	$4,120,000	–	217,000	–	1.46%	–
ARDX	Buy	ARDELYX	$3,920,000	+40.7%	700,000	+28.1%	1.39%	+19.1%
XLRN	Buy	ACCELERON PHARMA INC	$3,788,000	+24.6%	101,500	+1.5%	1.34%	+5.6%
INSM	New	INSMED INC	$3,745,000	–	120,000	–	1.32%	–
ITEK	New	INOTEK PHARMACEUTICALS CORP	$3,207,000	–	1,802,000	–	1.13%	–
	Sell	NEURODERM LTD	$2,723,000	-24.3%	70,000	-41.8%	0.96%	-35.9%
PETX	Buy	ARATANA THERAPEUTICS INC	$2,574,000	+12.9%	420,000	+19.9%	0.91%	-4.4%
SELB	New	SELECTA BIOSCIENCES INC	$1,733,000	–	95,000	–	0.61%	–
SYRS	Buy	SYROS PHARMACEUTICALS INC	$1,716,000	-2.6%	116,574	+6.5%	0.61%	-17.5%
ICPT	New	INTERCEPT PHARMACEUTICALS INC	$1,648,000	–	28,400	–	0.58%	–
ARQL	Buy	ARQULE INC	$1,354,000	+12.6%	1,220,000	+25.8%	0.48%	-4.8%
QUOT	New	QUOTIENT TECHNOLOGY INC	$542,000	–	110,000	–	0.19%	–
NEOS	Exit	NEOS THERAPEUTICS INC	$0	–	-50,000	–	-0.15%	–
SNSS	Exit	SUNESIS PHARMACEUTICALS INC	$0	–	-380,000	–	-0.43%	–
	Exit	INTRA CELLULAR THERAPIES INC	$0	–	-85,000	–	-0.44%	–
GBT	Exit	GLOBAL BLOOD THERAPEUTICS IN	$0	–	-40,000	–	-0.46%	–
EDGE	Exit	EDGE THERAPEUTICS INC	$0	–	-130,000	–	-0.56%	–
	Exit	PROTALIX BIOTHERAPEUTICS INC	$0	–	-1,835,000	–	-0.64%	–
TNXP	Exit	TONIX PHARMACEUTICALS HOLDING	$0	–	-370,000	–	-0.67%	–
ZSAN	Exit	ZOSANO PHARMA CORP	$0	–	-1,225,000	–	-0.72%	–
MIRN	Exit	MIRNA THERAPEUTICS INC	$0	–	-1,148,100	–	-0.80%	–
WVE	Exit	WAVE LIFE SCIENCES LTD	$0	–	-125,000	–	-0.97%	–
TTPH	Exit	TETRAPHASE PHARMACEUTICALS I	$0	–	-330,000	–	-0.98%	–
IMMY	Exit	IMPRIMIS PHARMACEUTICALS INC	$0	–	-895,000	–	-1.20%	–
PRTA	Exit	PROTHENA CORP PLC	$0	–	-85,000	–	-1.92%	–
ADMS	Exit	ADAMAS PHARMACEUTICALS INC	$0	–	-290,000	–	-2.12%	–
NVLNF	Exit	NOVELION THERAPEUTICS INC	$0	–	-750,000	–	-2.89%	–

Q2 2017

			Value		Shares		↓ Weighting
BPMC	New	BLUEPRINT MEDICINES	$44,589,000	–	880,000	–	18.62%	–
AXGN	New	AXOGEN INC	$32,997,000	–	1,970,000	–	13.78%	–
FGEN	New	FIBROGEN INC	$11,628,000	–	360,000	–	4.86%	–
LOXO	New	LOXO ONCOLOGY	$10,425,000	–	130,000	–	4.36%	–
SBBP	New	STRONGBRIDGE BIOPHARMA PLC	$8,437,000	–	1,180,000	–	3.52%	–
CDXS	New	CODEXIS INC	$8,011,000	–	1,470,000	–	3.35%	–
IMMU	New	IMMUNOMEDICS INC	$7,947,000	–	900,000	–	3.32%	–
MNTA	New	MOMENTA PHARMACEUTICALS INC	$7,605,000	–	450,000	–	3.18%	–
TBPH	New	THERAVANCE BIOPHARMA INC	$7,171,000	–	180,000	–	3.00%	–
CTMX	New	CYTOMX THERAPEUTICS INC	$7,130,000	–	460,000	–	2.98%	–
CMRX	New	CHIMERIX INC	$6,976,000	–	1,280,000	–	2.91%	–
NVLNF	New	NOVELION THERAPEUTICS INC	$6,922,000	–	750,000	–	2.89%	–
AGIO	New	AGIOS PHARMACEUTICALS	$6,688,000	–	130,000	–	2.79%	–
CORI	New	CORIUM INTERNATIONAL INC	$5,334,000	–	715,000	–	2.23%	–
FOMX	New	FOAMIX PHARMACEUTICALS LTD	$5,266,000	–	1,135,000	–	2.20%	–
SGMO	New	SANGAMO BIOSCIENCES INC	$5,104,000	–	580,000	–	2.13%	–
ADMS	New	ADAMAS PHARMACEUTICALS INC	$5,072,000	–	290,000	–	2.12%	–
EGRX	New	EAGLE PHARMACEUTICALS INC	$4,733,000	–	60,000	–	1.98%	–
PRTA	New	PROTHENA CORP PLC	$4,600,000	–	85,000	–	1.92%	–
ENTA	New	ENANTA PHARMACEUTICALS INC	$3,598,000	–	100,000	–	1.50%	–
	New	NEURODERM LTD	$3,597,000	–	120,300	–	1.50%	–
XLRN	New	ACCELERON PHARMA INC	$3,039,000	–	100,000	–	1.27%	–
BOLD	New	AUDENTES THERAPEUTICS INC	$2,869,000	–	150,000	–	1.20%	–
IMMY	New	IMPRIMIS PHARMACEUTICALS INC	$2,864,000	–	895,000	–	1.20%	–
ARDX	New	ARDELYX	$2,787,000	–	546,500	–	1.16%	–
TTPH	New	TETRAPHASE PHARMACEUTICALS I	$2,353,000	–	330,000	–	0.98%	–
WVE	New	WAVE LIFE SCIENCES LTD	$2,325,000	–	125,000	–	0.97%	–
PETX	New	ARATANA THERAPEUTICS INC	$2,279,000	–	350,200	–	0.95%	–
XOMA	New	XOMA CORP DEL	$2,217,000	–	317,200	–	0.93%	–
MIRN	New	MIRNA THERAPEUTICS INC	$1,917,000	–	1,148,100	–	0.80%	–
SYRS	New	SYROS PHARMACEUTICALS INC	$1,762,000	–	109,500	–	0.74%	–
ZSAN	New	ZOSANO PHARMA CORP	$1,727,000	–	1,225,000	–	0.72%	–
TNXP	New	TONIX PHARMACEUTICALS HOLDING	$1,602,000	–	370,000	–	0.67%	–
	New	PROTALIX BIOTHERAPEUTICS INC	$1,537,000	–	1,835,000	–	0.64%	–
EDGE	New	EDGE THERAPEUTICS INC	$1,334,000	–	130,000	–	0.56%	–
ARQL	New	ARQULE INC	$1,203,000	–	970,000	–	0.50%	–
GBT	New	GLOBAL BLOOD THERAPEUTICS IN	$1,094,000	–	40,000	–	0.46%	–
	New	INTRA CELLULAR THERAPIES INC	$1,056,000	–	85,000	–	0.44%	–
SNSS	New	SUNESIS PHARMACEUTICALS INC	$1,026,000	–	380,000	–	0.43%	–
NEOS	New	NEOS THERAPEUTICS INC	$365,000	–	50,000	–	0.15%	–
BLRX	New	BIOLINERX LTDsponsored adr	$212,000	–	250,000	–	0.09%	–

Q4 2016

			Value		Shares		↓ Weighting
DEPO	Exit	DEPOMED INC	$0	–	-1,650	–	-0.02%	–
BLRX	Exit	BIOLINERX LTDsponsored adr	$0	–	-250,000	–	-0.15%	–
AMAG	Exit	AMAG PHARMACEUTICALS INC	$0	–	-15,000	–	-0.19%	–
ABEO	Exit	ABEONA THERAPEUTICS INC	$0	–	-100,000	–	-0.31%	–
	Exit	PORTOLA PHARMACEUTICALS INC	$0	–	-35,000	–	-0.42%	–
TENX	Exit	TENAX THERAPEUTICS INC	$0	–	-390,000	–	-0.47%	–
	Exit	INTEC PHARMA LTD JERUSALEM	$0	–	-175,000	–	-0.54%	–
AFMD	Exit	AFFIMED N V	$0	–	-430,000	–	-0.62%	–
INNL	Exit	INNOCOLL HLDGS PLC	$0	–	-269,100	–	-0.82%	–
NBRV	Exit	NABRIVA THERAPEUTICS AGsponsored adr	$0	–	-239,500	–	-0.88%	–
	Exit	NEURODERM LTD	$0	–	-98,500	–	-0.95%	–
AMRN	Exit	AMARIN CORP PLCspons adr new	$0	–	-700,000	–	-1.17%	–
CORI	Exit	CORIUM INTL INC	$0	–	-400,000	–	-1.18%	–
LBIO	Exit	LION BIOTECHNOLOGIES INC	$0	–	-280,000	–	-1.21%	–
PTI	Exit	PROTEOSTASIS THERAPEUTICS IN	$0	–	-152,000	–	-1.24%	–
RARE	Exit	ULTRAGENYX PHARMACEUTICAL IN	$0	–	-35,000	–	-1.30%	–
CTMX	Exit	CYTOMX THERAPEUTICS INC	$0	–	-160,000	–	-1.31%	–
ZGNX	Exit	ZOGENIX INC	$0	–	-220,000	–	-1.32%	–
	Exit	TRILLIUM THERAPEUTICS INC	$0	–	-175,000	–	-1.35%	–
LOXO	Exit	LOXO ONCOLOGY INC	$0	–	-110,000	–	-1.51%	–
EDGE	Exit	EDGE THERAPEUTICS INC	$0	–	-280,000	–	-1.53%	–
PRTA	Exit	PROTHENA CORP PLC	$0	–	-50,000	–	-1.57%	–
XENE	Exit	XENON PHARMACEUTICALS INC	$0	–	-410,000	–	-1.74%	–
	Exit	INOTEK PHARMACEUTICALS CORP	$0	–	-400,000	–	-1.98%	–
IMMU	Exit	IMMUNOMEDICS INC	$0	–	-1,200,000	–	-2.04%	–
ADMS	Exit	ADAMAS PHARMACEUTICALS INC	$0	–	-250,000	–	-2.15%	–
AQXP	Exit	AQUINOX PHARMACEUTICALS INC	$0	–	-310,000	–	-2.17%	–
CMRX	Exit	CHIMERIX INC	$0	–	-780,000	–	-2.26%	–
MGNX	Exit	MACROGENICS INC	$0	–	-145,000	–	-2.27%	–
	Exit	PROTALIX BIOTHERAPEUTICS INC	$0	–	-8,070,000	–	-2.41%	–
GBT	Exit	GLOBAL BLOOD THERAPEUTICS IN	$0	–	-200,000	–	-2.41%	–
IMMY	Exit	IMPRIMIS PHARMACEUTICALS INC	$0	–	-1,215,381	–	-2.42%	–
EGRX	Exit	EAGLE PHARMACEUTICALS INC	$0	–	-70,000	–	-2.56%	–
HZNP	Exit	HORIZON GLOBAL CORP	$0	–	-275,000	–	-2.61%	–
CYNA	Exit	CYNAPSUS THERAPEUTICS INC	$0	–	-125,000	–	-2.63%	–
CDXS	Exit	CODEXIS INC	$0	–	-1,170,000	–	-2.72%	–
CARA	Exit	CARA THERAPEUTICS INC	$0	–	-675,000	–	-2.95%	–
FOMX	Exit	FOAMIX PHARMACEUTICALS LTD	$0	–	-630,000	–	-3.05%	–
FGEN	Exit	FIBROGEN INC	$0	–	-330,000	–	-3.58%	–
AGIO	Exit	AGIOS PHARMACEUTICALS	$0	–	-130,000	–	-3.59%	–
MDGN	Exit	MEDGENICS INC	$0	–	-1,800,000	–	-5.25%	–
ARIA	Exit	ARIAD PHARMACEUTICALS INC	$0	–	-1,045,000	–	-7.49%	–
AXGN	Exit	AXOGEN INC	$0	–	-2,000,000	–	-9.45%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-785,000	–	-12.20%	–

Q3 2016

			Value		Shares		↓ Weighting
BPMC	Buy	BLUEPRINT MEDICINES CORP	$23,315,000	+360.5%	785,000	+214.0%	12.20%	+260.8%
AXGN	Sell	AXOGEN INC	$18,060,000	+23.8%	2,000,000	-5.7%	9.45%	-3.0%
ARIA	Sell	ARIAD PHARMACEUTICALS INC	$14,306,000	+54.9%	1,045,000	-16.4%	7.49%	+21.3%
MDGN	Sell	MEDGENICS INC	$10,026,000	-7.4%	1,800,000	-7.7%	5.25%	-27.4%
AGIO	Buy	AGIOS PHARMACEUTICALS	$6,867,000	+92.8%	130,000	+52.9%	3.59%	+51.1%
FOMX	Sell	FOAMIX PHARMACEUTICALS LTD	$5,834,000	+32.2%	630,000	-9.4%	3.05%	+3.6%
CARA	Sell	CARA THERAPEUTICS INC	$5,636,000	+40.3%	675,000	-19.2%	2.95%	+10.0%
CDXS	Sell	CODEXIS INC	$5,195,000	+9.4%	1,170,000	-0.7%	2.72%	-14.3%
HZNP	Buy	HORIZON GLOBAL CORP	$4,986,000	+51.4%	275,000	+37.5%	2.61%	+18.6%
EGRX	Buy	EAGLE PHARMACEUTICALS INC	$4,900,000	+152.6%	70,000	+40.0%	2.56%	+97.8%
IMMY	Sell	IMPRIMIS PHARMACEUTICALS INC	$4,631,000	-2.8%	1,215,381	-4.1%	2.42%	-23.9%
GBT	Buy	GLOBAL BLOOD THERAPEUTICS IN	$4,610,000	+82.8%	200,000	+31.6%	2.41%	+43.2%
	Sell	PROTALIX BIOTHERAPEUTICS INC	$4,600,000	-12.3%	8,070,000	-1.6%	2.41%	-31.3%
MGNX	Buy	MACROGENICS INC	$4,337,000	+43.5%	145,000	+29.5%	2.27%	+12.4%
CMRX	Buy	CHIMERIX INC	$4,321,000	+62.9%	780,000	+15.6%	2.26%	+27.6%
AQXP	Buy	AQUINOX PHARMACEUTICALS INC	$4,142,000	+112.1%	310,000	+5.1%	2.17%	+66.1%
ADMS	Sell	ADAMAS PHARMACEUTICALS INC	$4,103,000	-9.7%	250,000	-16.7%	2.15%	-29.2%
IMMU	Sell	IMMUNOMEDICS INC	$3,900,000	+29.3%	1,200,000	-7.7%	2.04%	+1.3%
	Sell	INOTEK PHARMACEUTICALS CORP	$3,792,000	-21.0%	400,000	-38.0%	1.98%	-38.1%
PRTA	New	PROTHENA CORP PLC	$2,999,000	–	50,000	–	1.57%	–
EDGE	Buy	EDGE THERAPEUTICS INC	$2,915,000	+27.8%	280,000	+24.1%	1.53%	+0.1%
LOXO	New	LOXO ONCOLOGY INC	$2,880,000	–	110,000	–	1.51%	–
	Sell	TRILLIUM THERAPEUTICS INC	$2,587,000	+47.7%	175,000	-10.3%	1.35%	+15.7%
ZGNX	Sell	ZOGENIX INC	$2,515,000	+30.2%	220,000	-8.3%	1.32%	+1.9%
RARE	Sell	ULTRAGENYX PHARMACEUTICAL IN	$2,483,000	-21.9%	35,000	-46.2%	1.30%	-38.8%
PTI	Buy	PROTEOSTASIS THERAPEUTICS IN	$2,370,000	+86.0%	152,000	+44.8%	1.24%	+45.7%
LBIO	Buy	LION BIOTECHNOLOGIES INC	$2,304,000	+9.4%	280,000	+7.7%	1.21%	-14.3%
CORI	Buy	CORIUM INTL INC	$2,252,000	+80.3%	400,000	+11.1%	1.18%	+41.4%
AMRN	Sell	AMARIN CORP PLCspons adr new	$2,233,000	-41.3%	700,000	-60.2%	1.17%	-54.0%
	Buy	NEURODERM LTD	$1,821,000	+113.5%	98,500	+87.6%	0.95%	+67.2%
NBRV	Sell	NABRIVA THERAPEUTICS AGsponsored adr	$1,688,000	-16.6%	239,500	-11.3%	0.88%	-34.7%
INNL	Buy	INNOCOLL HLDGS PLC	$1,563,000	+7.1%	269,100	+1.5%	0.82%	-16.1%
AFMD	Sell	AFFIMED N V	$1,195,000	-19.0%	430,000	-27.7%	0.62%	-36.6%
	Sell	INTEC PHARMA LTD JERUSALEM	$1,029,000	-65.6%	175,000	-73.1%	0.54%	-73.0%
TENX	Sell	TENAX THERAPEUTICS INC	$905,000	-23.9%	390,000	-16.1%	0.47%	-40.4%
	New	PORTOLA PHARMACEUTICALS INC	$795,000	–	35,000	–	0.42%	–
ABEO	New	ABEONA THERAPEUTICS INC	$600,000	–	100,000	–	0.31%	–
AMAG	Sell	AMAG PHARMACEUTICALS INC	$368,000	-87.2%	15,000	-87.5%	0.19%	-89.9%
DEPO	New	DEPOMED INC	$41,000	–	1,650	–	0.02%	–
ADAP	Exit	ADAPTIMMUNE THERAPEUTICS PLCsponds adr	$0	–	-40,000	–	-0.22%	–
CDTX	Exit	CIDARA THERAPEUTICS INC	$0	–	-43,000	–	-0.30%	–
EVOK	Exit	EVOKE PHARMA INC	$0	–	-130,000	–	-0.60%	–
TGTX	Exit	TG THERAPEUTICS INC	$0	–	-175,000	–	-0.71%	–
OCUL	Exit	OCULAR THERAPEUTIX INC	$0	–	-260,000	–	-0.86%	–
EARS	Exit	AURIS MED HLDG AG	$0	–	-340,000	–	-0.95%	–
TNXP	Exit	TONIX PHARMACEUTICALS HLDG C	$0	–	-800,000	–	-1.06%	–
MCRB	Exit	SERES THERAPEUTICS INC	$0	–	-57,500	–	-1.12%	–
PRTK	Exit	PARATEK PHARMACEUTICALS INC	$0	–	-146,700	–	-1.36%	–
SUPN	Exit	SUPERNUS PHARMACEUTICALS INC	$0	–	-125,000	–	-1.70%	–

Q2 2016

			Value		Shares		↓ Weighting
AXGN	New	AXOGEN INC	$14,586,000	–	2,120,000	–	9.74%	–
MDGN	New	MEDGENICS INC	$10,823,000	–	1,950,000	–	7.23%	–
ARIA	New	ARIAD PHARMACEUTICALS INC	$9,238,000	–	1,250,000	–	6.17%	–
FGEN	New	FIBROGEN INC	$5,415,000	–	330,000	–	3.62%	–
	New	PROTALIX BIOTHERAPEUTICS INC	$5,248,000	–	8,200,000	–	3.50%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$5,063,000	–	250,000	–	3.38%	–
	New	INOTEK PHARMACEUTICALS CORP	$4,799,000	–	645,000	–	3.21%	–
IMMY	New	IMPRIMIS PHARMACEUTICALS INC	$4,766,000	–	1,267,500	–	3.18%	–
CDXS	New	CODEXIS INC	$4,749,000	–	1,178,500	–	3.17%	–
ADMS	New	ADAMAS PHARMACEUTICALS INC	$4,542,000	–	300,000	–	3.03%	–
FOMX	New	FOAMIX PHARMACEUTICALS LTD	$4,413,000	–	695,000	–	2.95%	–
CARA	New	CARA THERAPEUTICS INC	$4,016,000	–	835,000	–	2.68%	–
AMRN	New	AMARIN CORP PLCspons adr new	$3,802,000	–	1,760,000	–	2.54%	–
AGIO	New	AGIOS PHARMACEUTICALS	$3,561,000	–	85,000	–	2.38%	–
HZNP	New	HORIZON PHARMA PLC	$3,294,000	–	200,000	–	2.20%	–
RARE	New	ULTRAGENYX PHARMACEUTICAL IN	$3,179,000	–	65,000	–	2.12%	–
MGNX	New	MACROGENICS INC	$3,023,000	–	112,000	–	2.02%	–
IMMU	New	IMMUNOMEDICS INC	$3,016,000	–	1,300,000	–	2.02%	–
	New	INTEC PHARMA LTD JERUSALEM	$2,989,000	–	650,000	–	2.00%	–
AMAG	New	AMAG PHARMACEUTICALS INC	$2,870,000	–	120,000	–	1.92%	–
CMRX	New	CHIMERIX INC	$2,653,000	–	675,000	–	1.77%	–
SUPN	New	SUPERNUS PHARMACEUTICALS INC	$2,546,000	–	125,000	–	1.70%	–
GBT	New	GLOBAL BLOOD THERAPEUTICS IN	$2,522,000	–	152,000	–	1.68%	–
XENE	New	XENON PHARMACEUTICALS INC	$2,419,000	–	410,000	–	1.62%	–
EDGE	New	EDGE THERAPEUTICS INC	$2,281,000	–	225,600	–	1.52%	–
LBIO	New	LION BIOTECHNOLOGIES INC	$2,106,000	–	260,000	–	1.41%	–
CYNA	New	CYNAPSUS THERAPEUTICS INC	$2,094,000	–	125,000	–	1.40%	–
PRTK	New	PARATEK PHARMACEUTICALS INC	$2,041,000	–	146,700	–	1.36%	–
NBRV	New	NABRIVA THERAPEUTICS AGsponsored adr	$2,025,000	–	270,000	–	1.35%	–
AQXP	New	AQUINOX PHARMACEUTICALS INC	$1,953,000	–	295,000	–	1.30%	–
EGRX	New	EAGLE PHARMACEUTICALS INC	$1,940,000	–	50,000	–	1.30%	–
ZGNX	New	ZOGENIX INC	$1,932,000	–	240,000	–	1.29%	–
	New	TRILLIUM THERAPEUTICS INC	$1,751,000	–	195,000	–	1.17%	–
MCRB	New	SERES THERAPEUTICS INC	$1,670,000	–	57,500	–	1.12%	–
CTMX	New	CYTOMX THERAPEUTICS INC	$1,634,000	–	160,000	–	1.09%	–
TNXP	New	TONIX PHARMACEUTICALS HLDG C	$1,592,000	–	800,000	–	1.06%	–
AFMD	New	AFFIMED NV	$1,476,000	–	595,000	–	0.99%	–
INNL	New	INNOCOLL HOLDINGS PLC	$1,460,000	–	265,000	–	0.98%	–
EARS	New	AURIS MED HLDG AG	$1,425,000	–	340,000	–	0.95%	–
OCUL	New	OCULAR THERAPEUTIX INC	$1,287,000	–	260,000	–	0.86%	–
PTI	New	PROTEOSTASIS THERAPEUTICS IN	$1,274,000	–	105,000	–	0.85%	–
CORI	New	CORIUM INTL INC	$1,249,000	–	360,000	–	0.83%	–
TENX	New	TENAX THERAPEUTICS INC	$1,190,000	–	465,000	–	0.80%	–
TGTX	New	TG THERAPEUTICS INC	$1,061,000	–	175,000	–	0.71%	–
EVOK	New	EVOKE PHARMA INC	$891,000	–	130,000	–	0.60%	–
	New	NEURODERM LTD	$853,000	–	52,500	–	0.57%	–
CDTX	New	CIDARA THERAPEUTICS INC	$443,000	–	43,000	–	0.30%	–
ADAP	New	ADAPTIMMUNE THERAPEUTICS PLCsponds adr	$326,000	–	40,000	–	0.22%	–
BLRX	New	BIOLINERX LTDsponsored adr	$223,000	–	250,000	–	0.15%	–

Q4 2015

			Value		Shares		↓ Weighting
	Exit	TRACON PHARMACEUTICALS INC	$0	–	-12,172	–	-0.06%	–
BLRX	Exit	BIOLINERX LTDsponsored adr	$0	–	-250,000	–	-0.19%	–
CYNA	Exit	CYNAPSUS THERAPEUTICS INC	$0	–	-29,000	–	-0.23%	–
ALDR	Exit	ALDER PHARMACEUTICALS INC	$0	–	-16,100	–	-0.26%	–
CELGZ	Exit	CELGENE CORPrights 12/31/2030	$0	–	-340,000	–	-0.27%	–
INNL	Exit	INNOCOLL AGsponsored adr	$0	–	-55,543	–	-0.34%	–
EVOK	Exit	EVOKE PHARMA INC	$0	–	-260,000	–	-0.37%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-20,000	–	-0.42%	–
XENE	Exit	XENON PHARMACEUTICALS INC	$0	–	-151,300	–	-0.62%	–
EARS	Exit	AURIS MED HLDG AG	$0	–	-355,000	–	-0.62%	–
AXDX	Exit	ACCELERATE DIAGNOSTICS INC	$0	–	-95,000	–	-0.76%	–
TENX	Exit	TENAX THERAPEUTICS INC	$0	–	-635,000	–	-0.94%	–
FOMX	Exit	FOAMIX PHARMACEUTICALS LTD	$0	–	-285,000	–	-1.03%	–
XOMA	Exit	XOMA CORP DEL	$0	–	-2,950,000	–	-1.09%	–
NVLS	Exit	NIVALIS THERAPEUTICS INC	$0	–	-175,200	–	-1.12%	–
AVGR	Exit	AVINGER INC	$0	–	-175,000	–	-1.27%	–
AGRX	Exit	AGILE THERAPEUTICS INC	$0	–	-385,000	–	-1.28%	–
TGTX	Exit	TG THERAPEUTICS INC	$0	–	-260,000	–	-1.29%	–
MNTA	Exit	MOMENTA PHARMACEUTICALS INC	$0	–	-160,000	–	-1.29%	–
ADMS	Exit	ADAMAS PHARMACEUTICALS INC	$0	–	-165,700	–	-1.36%	–
BPMC	Exit	BLUEPRINT MEDICINES CORPrights	$0	–	-130,000	–	-1.36%	–
TNXP	Exit	TONIX PHARMACEUTICALS HLDG C	$0	–	-570,000	–	-1.48%	–
	Exit	TRILLIUM THERAPEUTICS INC	$0	–	-245,275	–	-1.57%	–
ZGNX	Exit	ZOGENIX INC	$0	–	-250,000	–	-1.66%	–
AMRN	Exit	AMARIN CORP PLCspons adr new	$0	–	-1,760,000	–	-1.67%	–
	Exit	INTEC PHARMA LTD JERUSALEM	$0	–	-630,000	–	-1.74%	–
	Exit	CYTRX CORP	$0	–	-1,525,000	–	-1.78%	–
AFMD	Exit	AFFIMED N V	$0	–	-590,300	–	-1.79%	–
OPHT	Exit	OPHTHOTECH CORP	$0	–	-105,000	–	-2.09%	–
	Exit	PROTALIX BIOTHERAPEUTICS INC	$0	–	-3,640,000	–	-2.11%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-125,000	–	-2.45%	–
GERN	Exit	GERON CORP	$0	–	-1,825,000	–	-2.48%	–
FLML	Exit	FLAMEL TECHNOLOGIES SAsponsored adr	$0	–	-310,000	–	-2.49%	–
EGRX	Exit	EAGLE PHARMACEUTICALS INC	$0	–	-73,200	–	-2.67%	–
CDXS	Exit	CODEXIS INC	$0	–	-1,620,000	–	-2.70%	–
CARA	Exit	CARA THERAPEUTICS INC	$0	–	-415,000	–	-2.92%	–
	Exit	INOTEK PHARMACEUTICALS CORP	$0	–	-642,800	–	-2.97%	–
ZSPH	Exit	ZS PHARMA INC	$0	–	-95,000	–	-3.07%	–
SUPN	Exit	SUPERNUS PHARMACEUTICALS INC	$0	–	-460,000	–	-3.18%	–
FGEN	Exit	FIBROGEN INC	$0	–	-325,000	–	-3.51%	–
RTRX	Exit	RETROPHIN INC	$0	–	-370,000	–	-3.69%	–
ARIA	Exit	ARIAD PHARMACEUTICALS INC	$0	–	-1,310,000	–	-3.76%	–
IMMY	Exit	IMPRIMIS PHARMACEUTICALS INC	$0	–	-1,205,000	–	-3.81%	–
AMAG	Exit	AMAG PHARMACEUTICALS INC	$0	–	-200,000	–	-3.91%	–
MDGN	Exit	MEDGENICS INC	$0	–	-1,058,400	–	-4.07%	–
AXGN	Exit	AXOGEN INC	$0	–	-2,120,000	–	-4.30%	–
CEMP	Exit	CEMPRA INC	$0	–	-360,000	–	-4.93%	–
RARE	Exit	ULTRAGENYX PHARMACEUTICAL IN	$0	–	-110,000	–	-5.21%	–
CMRX	Exit	CHIMERIX INC	$0	–	-310,000	–	-5.83%	–

Q3 2015

			Value		Shares		↓ Weighting
CMRX	Sell	CHIMERIX INC	$11,842,000	-41.7%	310,000	-29.5%	5.83%	-28.0%
CEMP	Sell	CEMPRA INC	$10,022,000	-40.5%	360,000	-26.5%	4.93%	-26.4%
MDGN	Buy	MEDGENICS INC	$8,277,000	+28.6%	1,058,400	+0.8%	4.07%	+59.0%
AMAG	Buy	AMAG PHARMACEUTICALS INC	$7,946,000	-39.4%	200,000	+5.3%	3.91%	-25.1%
ARIA	Sell	ARIAD PHARMACEUTICALS INC	$7,650,000	-38.3%	1,310,000	-12.7%	3.76%	-23.7%
RTRX	Sell	RETROPHIN INC	$7,496,000	-50.8%	370,000	-19.6%	3.69%	-39.2%
SUPN	Sell	SUPERNUS PHARMACEUTICALS INC	$6,454,000	-29.0%	460,000	-14.0%	3.18%	-12.1%
	Buy	INOTEK PHARMACEUTICALS CORP	$6,042,000	+103.9%	642,800	+6.3%	2.97%	+152.2%
CARA	Buy	CARA THERAPEUTICS INC	$5,930,000	+43.5%	415,000	+22.1%	2.92%	+77.5%
CDXS	Sell	CODEXIS INC	$5,492,000	-18.1%	1,620,000	-6.0%	2.70%	+1.3%
EGRX	Buy	EAGLE PHARMACEUTICALS INC	$5,419,000	+34.0%	73,200	+46.4%	2.67%	+65.8%
NBIX	Sell	NEUROCRINE BIOSCIENCES INC	$4,973,000	-28.2%	125,000	-13.8%	2.45%	-11.2%
	Buy	PROTALIX BIOTHERAPEUTICS INC	$4,295,000	-12.1%	3,640,000	+45.3%	2.11%	+8.7%
	New	CYTRX CORP	$3,614,000	–	1,525,000	–	1.78%	–
	New	INTEC PHARMA LTD JERUSALEM	$3,528,000	–	630,000	–	1.74%	–
AMRN	Buy	AMARIN CORP PLCspons adr new	$3,397,000	-21.3%	1,760,000	+0.3%	1.67%	-2.6%
ZGNX	Sell	ZOGENIX INC	$3,375,000	+120.2%	250,000	-72.6%	1.66%	+172.3%
	Sell	TRILLIUM THERAPEUTICS INC	$3,196,000	-41.4%	245,275	-1.9%	1.57%	-27.5%
TNXP	Buy	TONIX PHARMACEUTICALS HLDG C	$3,015,000	+76.9%	570,000	+200.0%	1.48%	+118.9%
BPMC	New	BLUEPRINT MEDICINES CORPrights	$2,774,000	–	130,000	–	1.36%	–
ADMS	Buy	ADAMAS PHARMACEUTICALS INC	$2,774,000	-29.5%	165,700	+10.5%	1.36%	-12.8%
MNTA	New	MOMENTA PHARMACEUTICALS INC	$2,626,000	–	160,000	–	1.29%	–
TGTX	New	TG THERAPEUTICS INC	$2,621,000	–	260,000	–	1.29%	–
AGRX	Buy	AGILE THERAPEUTICS INC	$2,595,000	+449.8%	385,000	+600.0%	1.28%	+579.3%
AVGR	Sell	AVINGER INC	$2,574,000	-4.2%	175,000	-15.9%	1.27%	+18.4%
NVLS	New	NIVALIS THERAPEUTICS INC	$2,272,000	–	175,200	–	1.12%	–
XOMA	Buy	XOMA CORP DEL	$2,218,000	-12.1%	2,950,000	+353.8%	1.09%	+8.8%
FOMX	Buy	FOAMIX PHARMACEUTICALS LTD	$2,089,000	+139.8%	285,000	+235.3%	1.03%	+196.3%
AXDX	Sell	ACCELERATE DIAGNOSTICS INC	$1,537,000	-40.8%	95,000	-5.6%	0.76%	-26.8%
XENE	New	XENON PHARMACEUTICALS INC	$1,250,000	–	151,300	–	0.62%	–
SAGE	New	SAGE THERAPEUTICS INC	$846,000	–	20,000	–	0.42%	–
EVOK	Buy	EVOKE PHARMA INC	$757,000	-44.1%	260,000	+0.3%	0.37%	-30.8%
INNL	Sell	INNOCOLL AGsponsored adr	$695,000	-53.1%	55,543	-45.1%	0.34%	-41.9%
CELGZ	Sell	CELGENE CORPrights 12/31/2030	$547,000	-42.4%	340,000	-25.5%	0.27%	-28.8%
ALDR	New	ALDER PHARMACEUTICALS INC	$527,000	–	16,100	–	0.26%	–
CYNA	New	CYNAPSUS THERAPEUTICS INC	$469,000	–	29,000	–	0.23%	–
DERM	Exit	DERMIRA INC	$0	–	-18,800	–	-0.13%	–
	Exit	NEURODERM LTD	$0	–	-26,000	–	-0.16%	–
TTPH	Exit	TETRAPHASE PHARMACEUTICALS I	$0	–	-65,000	–	-1.23%	–
INSYQ	Exit	INSYS THERAPEUTICS INC NEW	$0	–	-89,000	–	-1.27%	–
MGNX	Exit	MACROGENICS INC	$0	–	-90,000	–	-1.36%	–
MDXG	Exit	MIMEDX GROUP INC	$0	–	-617,000	–	-2.84%	–
CLVS	Exit	CLOVIS ONCOLOGY INC	$0	–	-90,000	–	-3.15%	–

Q2 2015

			Value		Shares		↓ Weighting
CMRX	New	CHIMERIX INC	$20,328,000	–	440,000	–	8.09%	–
CEMP	New	CEMPRA INC	$16,836,000	–	490,000	–	6.70%	–
RTRX	New	RETROPHIN INC	$15,249,000	–	460,000	–	6.07%	–
AMAG	New	AMAG PHARMACEUTICALS INC	$13,121,000	–	190,000	–	5.22%	–
ARIA	New	ARIAD PHARMACEUTICALS INC	$12,405,000	–	1,500,000	–	4.94%	–
RARE	New	ULTRAGENYX PHARMACEUTICAL IN	$11,263,000	–	110,000	–	4.48%	–
IMMY	New	IMPRIMIS PHARMACEUTICALS INC	$9,797,000	–	1,205,000	–	3.90%	–
SUPN	New	SUPERNUS PHARMACEUTICALS INC	$9,084,000	–	535,000	–	3.61%	–
AFMD	New	AFFIMED NV	$7,951,000	–	590,300	–	3.16%	–
CLVS	New	CLOVIS ONCOLOGY INC	$7,909,000	–	90,000	–	3.15%	–
GERN	New	GERON CORP	$7,811,000	–	1,825,000	–	3.11%	–
FGEN	New	FIBROGEN INC	$7,638,000	–	325,000	–	3.04%	–
MDXG	New	MIMEDX GROUP INC	$7,151,000	–	617,000	–	2.84%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$6,925,000	–	145,000	–	2.76%	–
CDXS	New	CODEXIS INC	$6,706,000	–	1,724,000	–	2.67%	–
AXGN	New	AXOGEN INC	$6,657,000	–	2,120,000	–	2.65%	–
FLML	New	FLAMEL TECHNOLOGIES SA	$6,569,000	–	310,000	–	2.61%	–
MDGN	New	MEDGENICS INC	$6,437,000	–	1,050,000	–	2.56%	–
OPHT	New	OPHTHOTECH CORP	$5,487,000	–	105,000	–	2.18%	–
	New	TRILLIUM THERAPEUTICS INC	$5,455,000	–	250,000	–	2.17%	–
ZSPH	New	ZS PHARMA INC	$4,977,000	–	95,000	–	1.98%	–
	New	PROTALIX BIOTHERAPEUTICS INC	$4,885,000	–	2,505,000	–	1.94%	–
AMRN	New	AMARIN CORP PLC	$4,315,000	–	1,754,000	–	1.72%	–
CARA	New	CARA THERAPEUTICS INC	$4,131,000	–	340,000	–	1.64%	–
EGRX	New	EAGLE PHARMACEUTICALS INC	$4,043,000	–	50,000	–	1.61%	–
ADMS	New	ADAMAS PHARMACEUTICALS INC	$3,933,000	–	150,000	–	1.56%	–
MGNX	New	MACROGENICS INC	$3,417,000	–	90,000	–	1.36%	–
INSYQ	New	INSYS THERAPEUTICS INC NEW	$3,197,000	–	89,000	–	1.27%	–
TTPH	New	TETRAPHASE PHARMACEUTICALS I	$3,084,000	–	65,000	–	1.23%	–
	New	INOTEK PHARMACEUTICALS CORP	$2,963,000	–	604,700	–	1.18%	–
AVGR	New	AVINGER INC	$2,688,000	–	208,200	–	1.07%	–
AXDX	New	ACCELERATE DIAGNOSTICS INC	$2,596,000	–	100,600	–	1.03%	–
XOMA	New	XOMA CORP DEL	$2,522,000	–	650,000	–	1.00%	–
TENX	New	TENAX THERAPEUTICS INC	$2,343,000	–	635,000	–	0.93%	–
EARS	New	AURIS MED HLDG AG	$1,725,000	–	355,000	–	0.69%	–
TNXP	New	TONIX PHARMACEUTICALS HLDG C	$1,704,000	–	190,000	–	0.68%	–
ZGNX	New	ZOGENIX INC	$1,533,000	–	912,500	–	0.61%	–
INNL	New	INNOCOLL AG	$1,481,000	–	101,200	–	0.59%	–
EVOK	New	EVOKE PHARMA INC	$1,355,000	–	259,100	–	0.54%	–
CELGZ	New	CELGENE CORPrights	$950,000	–	456,492	–	0.38%	–
FOMX	New	FOAMIX PHARMACEUTICALS LTD	$871,000	–	85,000	–	0.35%	–
BLRX	New	BIOLINERX LTD	$495,000	–	250,000	–	0.20%	–
AGRX	New	AGILE THERAPEUTICS INC	$472,000	–	55,000	–	0.19%	–
	New	NEURODERM LTD	$399,000	–	26,000	–	0.16%	–
DERM	New	DERMIRA INC	$330,000	–	18,800	–	0.13%	–
	New	TRACON PHARMACEUTICALS INC	$138,000	–	12,172	–	0.06%	–

Q4 2014

			Value		Shares		↓ Weighting
KIPS	Exit	KIPS BAY MED INC	$0	–	-50,000	–	-0.01%	–
BLRX	Exit	BIOLINERX LTD	$0	–	-490,000	–	-0.59%	–
CPXX	Exit	CELATOR PHARMACEUTICALS INC	$0	–	-405,000	–	-0.80%	–
OPHT	Exit	OPHTHOTECH CORP	$0	–	-35,000	–	-1.06%	–
EVOK	Exit	EVOKE PHARMA	$0	–	-267,000	–	-1.14%	–
GERN	Exit	GERON CORP	$0	–	-820,000	–	-1.28%	–
FLDM	Exit	FLUIDIGM CORP DEL	$0	–	-67,000	–	-1.28%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-134,500	–	-1.34%	–
AXDX	Exit	ACCELERATE DIAGNOSTICS INC	$0	–	-89,200	–	-1.49%	–
AEGR	Exit	AEGERION PHARMACEUTICALS INC	$0	–	-57,500	–	-1.50%	–
CELGZ	Exit	CELGENE CORPright 12/31/2030	$0	–	-660,000	–	-1.74%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INC	$0	–	-29,100	–	-1.77%	–
CSII	Exit	CARDIOVASCULAR SYS INC DEL	$0	–	-125,000	–	-2.30%	–
CPRX	Exit	CATALYST PHARM PARTNERS INC	$0	–	-975,000	–	-2.52%	–
TTPH	Exit	TETRAPHASE PHARMACEUTICALS I	$0	–	-169,700	–	-2.64%	–
PRTA	Exit	PROTHENA CORP PLC	$0	–	-157,000	–	-2.71%	–
IMMY	Exit	IMPRIMIS PHARMACEUTICALS INC	$0	–	-502,500	–	-2.91%	–
BINDQ	Exit	BIND THERAPEUTICS INC	$0	–	-450,000	–	-3.01%	–
CDXS	Exit	CODEXIS INC	$0	–	-1,690,000	–	-3.07%	–
NSPR	Exit	INSPIREMD INC	$0	–	-2,088,500	–	-3.58%	–
INSYQ	Exit	INSYS THERAPEUTICS INC NEWS	$0	–	-122,500	–	-3.70%	–
RARE	Exit	ULTRAGENYX PHARMACEUTICAL IN	$0	–	-85,000	–	-3.75%	–
GNMK	Exit	GENMARK DIAGNOSTICS INC	$0	–	-550,000	–	-3.84%	–
CEMP	Exit	CEMPRA INC	$0	–	-504,800	–	-4.31%	–
CLVS	Exit	CLOVIS ONCOLOGY INC.	$0	–	-140,000	–	-4.84%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INC	$0	–	-113,500	–	-5.43%	–
ARIA	Exit	ARIAD PHARMACEUTICALS INC	$0	–	-1,500,000	–	-6.31%	–
RTRX	Exit	RETROPHIN INC	$0	–	-1,000,000	–	-7.03%	–
PCYC	Exit	PHARMACYCLICS INC	$0	–	-85,000	–	-7.78%	–
CMRX	Exit	CHIMERIX INC	$0	–	-755,000	–	-16.25%	–

Q3 2014

			Value		Shares		↓ Weighting
CMRX	Sell	CHIMERIX INC	$20,853,100,000	+120208.7%	755,000	-4.4%	16.25%	+8.8%
PCYC	Sell	PHARMACYCLICS INC	$9,981,550,000	+111164.6%	85,000	-15.0%	7.78%	+0.6%
RTRX	Sell	RETROPHIN INC	$9,020,000,000	+63060.8%	1,000,000	-17.8%	7.03%	-42.9%
ARIA	Sell	ARIAD PHARMACEUTICALS INC	$8,100,000,000	+76503.0%	1,500,000	-9.6%	6.31%	-30.7%
AGIO	Sell	AGIOS PHARMACEUTICALS INC	$6,963,225,000	+132054.6%	113,500	-1.3%	5.43%	+19.5%
CLVS	Buy	CLOVIS ONCOLOGY INC.	$6,210,400,000	+115571.4%	140,000	+7.7%	4.84%	+4.6%
GNMK	Buy	GENMARK DIAGNOSTICS INC	$4,933,500,000	+72826.8%	550,000	+10.0%	3.84%	-34.1%
RARE	Buy	ULTRAGENYX PHARMACEUTICAL IN	$4,811,000,000	+238068.3%	85,000	+88.9%	3.75%	+115.3%
INSYQ	Buy	INSYS THERAPEUTICS INC NEWS	$4,750,550,000	+177159.3%	122,500	+42.8%	3.70%	+60.2%
NSPR	Sell	INSPIREMD INC	$4,594,700,000	+71346.1%	2,088,500	-4.2%	3.58%	-35.4%
CDXS	Buy	CODEXIS INC	$3,937,700,000	+328864.1%	1,690,000	+106.1%	3.07%	+197.4%
BINDQ	Sell	BIND THERAPEUTICS INC	$3,865,500,000	+59506.8%	450,000	-8.5%	3.01%	-46.1%
IMMY	New	IMPRIMIS PHARMACEUTICALS INC	$3,728,550,000	–	502,500	–	2.91%	–
PRTA	Buy	PROTHENA CORP PLC	$3,479,120,000	+1179262.7%	157,000	+1098.1%	2.71%	+967.7%
CPRX	Sell	CATALYST PHARM PARTNERS INC	$3,237,000,000	+92703.9%	975,000	-29.3%	2.52%	-16.1%
CSII	Sell	CARDIOVASCULAR SYS INC DEL	$2,953,750,000	+70110.4%	125,000	-7.4%	2.30%	-36.5%
ALNY	Buy	ALNYLAM PHARMACEUTICALS INC	$2,272,710,000	+499396.7%	29,100	+304.2%	1.77%	+351.8%
AEGR	New	AEGERION PHARMACEUTICALS INC	$1,919,350,000	–	57,500	–	1.50%	–
AXDX	New	ACCELERATE DIAGNOSTICS INC	$1,916,016,000	–	89,200	–	1.49%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$1,712,185,000	–	134,500	–	1.34%	–
FLDM	New	FLUIDIGM CORP DEL	$1,641,500,000	–	67,000	–	1.28%	–
GERN	New	GERON CORP	$1,640,000,000	–	820,000	–	1.28%	–
EVOK	Buy	EVOKE PHARMA	$1,468,367,000	+74740.3%	267,000	+10.1%	1.14%	-32.3%
OPHT	New	OPHTHOTECH CORP	$1,362,550,000	–	35,000	–	1.06%	–
CPXX	Buy	CELATOR PHARMACEUTICALS INC	$1,024,650,000	+95393.9%	405,000	+19.7%	0.80%	-13.6%
BLRX	Sell	BIOLINERX LTD	$754,600,000	+55713.6%	490,000	-24.6%	0.59%	-49.6%
KIPS	Sell	KIPS BAY MED INC	$8,510,000	+2297.2%	50,000	-93.5%	0.01%	-97.7%
KBIO	Exit	KALOBIOS PHARMACEUTICALS INC	$0	–	-320,000	–	-0.63%	–
KPTI	Exit	KARYOPHARM THERAPEUTICS INC	$0	–	-30,000	–	-1.20%	–
REPH	Exit	RECRO PHARMA INC	$0	–	-220,000	–	-1.52%	–
MZOR	Exit	MAZOR ROBOTICS LTD	$0	–	-120,000	–	-1.82%	–

Q2 2014

			Value		Shares		↓ Weighting
CMRX	New	CHIMERIX INC	$17,333,000	–	790,000	–	14.94%	–
RTRX	New	RETROPHIN INC	$14,281,000	–	1,216,400	–	12.31%	–
ARIA	New	ARIAD PHARMACEUTICALS INC	$10,574,000	–	1,660,000	–	9.12%	–
PCYC	New	PHARMACYCLICS INC	$8,971,000	–	100,000	–	7.74%	–
GNMK	New	GENMARK DIAGNOSTICS INC	$6,765,000	–	500,000	–	5.83%	–
BINDQ	New	BIND THERAPEUTICS INC	$6,485,000	–	492,000	–	5.59%	–
NSPR	New	INSPIREMD INC	$6,431,000	–	2,180,000	–	5.54%	–
CEMP	New	CEMPRA INC	$5,417,000	–	504,800	–	4.67%	–
CLVS	New	CLOVIS ONCOLOGY INC	$5,369,000	–	130,000	–	4.63%	–
AGIO	New	AGIOS PHARMACEUTICALS INC	$5,269,000	–	115,000	–	4.54%	–
CSII	New	CARDIOVASCULAR SYS INC DEL	$4,207,000	–	135,000	–	3.63%	–
CPRX	New	CATALYST PHARM PARTNERS INC	$3,488,000	–	1,378,584	–	3.01%	–
INSYQ	New	INSYS THERAPEUTICS INC NEW	$2,680,000	–	85,800	–	2.31%	–
TTPH	New	TETRAPHASE PHARMACEUTICALS I	$2,289,000	–	169,700	–	1.97%	–
MZOR	New	MAZOR ROBOTICS LTD	$2,108,000	–	120,000	–	1.82%	–
RARE	New	ULTRAGENYX PHARMACEUTICAL IN	$2,020,000	–	45,000	–	1.74%	–
EVOK	New	EVOKE PHARMA INC	$1,962,000	–	242,500	–	1.69%	–
REPH	New	RECRO PHARMA INC	$1,762,000	–	220,000	–	1.52%	–
CELGZ	New	CELGENE CORPright 12/31/2030	$1,716,000	–	660,000	–	1.48%	–
KPTI	New	KARYOPHARM THERAPEUTICS INC	$1,397,000	–	30,000	–	1.20%	–
BLRX	New	BIOLINERX LTD	$1,352,000	–	650,000	–	1.17%	–
CDXS	New	CODEXIS INC	$1,197,000	–	820,000	–	1.03%	–
CPXX	New	CELATOR PHARMACEUTICALS INC	$1,073,000	–	338,402	–	0.92%	–
KBIO	New	KALOBIOS PHARMACEUTICALS INC	$730,000	–	320,000	–	0.63%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$455,000	–	7,200	–	0.39%	–
KIPS	New	KIPS BAY MED INC	$355,000	–	772,031	–	0.31%	–
PRTA	New	PROTHENA CORP PLC	$295,000	–	13,104	–	0.25%	–

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