$766 Million is the total value of Opaleye Management Inc.'s 59 reported holdings in Q4 2020. The portfolio turnover from Q3 2020 to Q4 2020 was 43.6% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| OCUL | Buy | OCULAR THERAPEUTIX INC | $134,758,000 | +195.9% | 6,510,000 | +8.8% | 17.60% | +97.6% |
| TARA | PROTARA THERAPEUTICS INC | $61,941,000 | +43.9% | 2,558,472 | 0.0% | 8.09% | -3.9% | |
| EIDX | EIDOS THERAPEUTICS INC | $41,520,000 | +160.4% | 315,550 | 0.0% | 5.42% | +73.9% | |
| ETON | Buy | ETON PHARMACEUTICALS INC | $32,845,000 | +14.2% | 4,040,000 | +11.0% | 4.29% | -23.7% |
| CDXS | CODEXIS INC | $30,562,000 | +85.9% | 1,400,000 | 0.0% | 3.99% | +24.2% | |
| CRDF | Sell | CARDIFF ONCOLOGY INC | $29,908,000 | +21.7% | 1,662,500 | -4.0% | 3.91% | -18.7% |
| TCON | Buy | TRACON PHARMACEUTICALS INC | $29,465,000 | +183.1% | 2,518,371 | +25.1% | 3.85% | +89.0% |
| CCXI | Sell | CHEMOCENTRYX INC | $21,672,000 | +11.1% | 350,000 | -1.7% | 2.83% | -25.8% |
| AFIB | ACUTUS MEDICAL INC | $21,607,000 | -3.3% | 749,990 | 0.0% | 2.82% | -35.4% | |
| HROW | Buy | HARROW HEALTH INC | $21,029,000 | +27.1% | 3,065,416 | +3.6% | 2.75% | -15.1% |
| TGTX | Sell | TG THERAPEUTICS INC | $20,158,000 | +93.2% | 387,500 | -0.6% | 2.63% | +29.0% |
| XOMA | XOMA CORP DEL | $20,079,000 | +134.2% | 455,000 | 0.0% | 2.62% | +56.5% | |
| NLTX | NEOLEUKIN THERAPEUTICS INC | $19,547,000 | +17.5% | 1,386,300 | 0.0% | 2.55% | -21.5% | |
| CMRX | Buy | CHIMERIX INC | $19,110,000 | +99.8% | 3,956,500 | +3.0% | 2.50% | +33.4% |
| CLDX | CELLDEX THERAPEUTICS INC | $17,380,000 | +18.1% | 992,000 | 0.0% | 2.27% | -21.1% | |
| STXS | STEREOTAXIS INC | $15,379,000 | +42.2% | 3,021,436 | 0.0% | 2.01% | -5.1% | |
| DCPH | DECIPHERA PHARMACEUTICALS IN | $12,670,000 | +11.2% | 222,000 | 0.0% | 1.66% | -25.7% | |
| FBIO | Buy | FORTRESS BIOTECH INC | $12,323,000 | +20.1% | 3,887,500 | +1.5% | 1.61% | -19.8% |
| CYTK | Buy | CYTOKINETICS INC | $12,111,000 | +167.9% | 582,800 | +179.1% | 1.58% | +79.0% |
| MYOV | MYOVANT SCIENCES LTD | $10,487,000 | +9.4% | 682,500 | 0.0% | 1.37% | -26.9% | |
| LUMO | Buy | LUMOS PHARMA INC | $10,045,000 | +201.7% | 281,287 | +16.8% | 1.31% | +101.5% |
| MCRB | SERES THERAPEUTICS | $9,804,000 | +3.3% | 335,312 | 0.0% | 1.28% | -31.0% | |
| BHVN | Sell | BIOHAVEN PHARMACEUTICAL HLDG | $9,771,000 | +31.4% | 114,000 | -0.3% | 1.28% | -12.2% |
| KALV | KALVISTA PHARMACEUTICALS INC | $8,929,000 | +52.3% | 470,203 | 0.0% | 1.17% | +1.7% | |
| PCVX | Buy | VAXCYTE | $8,906,000 | -42.4% | 335,200 | +7.1% | 1.16% | -61.5% |
| MGNX | Sell | MACROGENICS INC | $8,472,000 | -36.2% | 370,600 | -29.7% | 1.11% | -57.4% |
| FSDC | New | FS DEV CORP | $7,748,000 | – | 704,400 | +100.0% | 1.01% | – |
| PTGX | New | PROTAGONIST THERAPEUTICS INC | $7,020,000 | – | 260,000 | +100.0% | 0.92% | – |
| STRO | Buy | SUTRO BIOPHARMA INC | $6,995,000 | +376.8% | 322,200 | +120.7% | 0.91% | +218.5% |
| CERC | Sell | CERECOR INC | $6,917,000 | -9.9% | 2,620,000 | -22.3% | 0.90% | -39.8% |
| TCDA | New | TRICIDA INC | $6,761,000 | – | 959,000 | +100.0% | 0.88% | – |
| INFI | INFINITY PHARMACEUTICALS INC | $6,724,000 | +4808.0% | 3,171,800 | 0.0% | 0.88% | +3151.9% | |
| FPRX | New | FIVE PRIME THERAPEUTICS INC | $6,496,000 | – | 381,900 | +100.0% | 0.85% | – |
| ADMS | ADAMAS PHARMACEUTICALS INC | $6,442,000 | +5.1% | 1,487,800 | 0.0% | 0.84% | -29.9% | |
| MRUS | Buy | MERUS NV | $6,188,000 | +309300.0% | 353,000 | +176400.0% | 0.81% | – |
| SIOX | New | SIO GENE THERAPIES INC | $5,560,000 | – | 2,000,000 | +100.0% | 0.73% | – |
| TELA | Buy | TELA BIO INC | $5,490,000 | -8.3% | 365,000 | +0.8% | 0.72% | -38.8% |
| FGEN | FIBROGEN INC | $5,452,000 | -9.8% | 147,000 | 0.0% | 0.71% | -39.8% | |
| VSTM | Buy | VERASTEM INC | $4,761,000 | +48.7% | 2,325,000 | +5.7% | 0.62% | -0.6% |
| MEIP | MEI PHARMA INC | $4,108,000 | -15.4% | 1,556,000 | 0.0% | 0.54% | -43.5% | |
| KNSA | Sell | KINIKSA PHARMACEUTICALS LTD | $3,960,000 | -54.9% | 224,100 | -33.7% | 0.52% | -69.9% |
| KZR | Buy | KEZAR LIFE SCIENCES INC | $3,696,000 | +12.6% | 708,000 | +4.4% | 0.48% | -24.8% |
| Sell | APTOSE BIOSCIENCES INC | $3,504,000 | -67.5% | 800,000 | -55.5% | 0.46% | -78.3% | |
| PRAX | New | PRAXIS PRECISION MEDICINES INC | $3,489,000 | – | 63,416 | +100.0% | 0.46% | – |
| RYTM | New | RHYTHM PHARMACEUTICALS INC | $3,419,000 | – | 115,000 | +100.0% | 0.45% | – |
| EDAP | Sell | EDAP TMS SAsponsored adr | $3,399,000 | -29.0% | 657,500 | -36.8% | 0.44% | -52.6% |
| EPIX | Buy | ESSA PHARMA INC | $3,389,000 | +81.0% | 284,050 | +4.7% | 0.44% | +21.0% |
| CNCE | Buy | CONCERT PHARMACEUTICALS INC | $3,211,000 | +227.0% | 254,000 | +154.0% | 0.42% | +118.2% |
| CFRX | Buy | CONTRAFECT CORP | $2,222,000 | +86.1% | 440,000 | +94.6% | 0.29% | +23.9% |
| OPTN | New | OPTINOSE INC | $1,801,000 | – | 435,000 | +100.0% | 0.24% | – |
| SRRA | New | SIERRA ONCOLOGY INC | $1,208,000 | – | 75,379 | +100.0% | 0.16% | – |
| AMRN | AMARIN CORP PLCsponsored adr new | $1,100,000 | +16.2% | 225,000 | 0.0% | 0.14% | -22.2% | |
| FULC | Sell | FULCRUM THERAPEUTICS INC | $1,034,000 | -71.1% | 88,300 | -80.5% | 0.14% | -80.7% |
| CBIO | New | CATALYST BIOSCIENCES INC | $939,000 | – | 148,800 | +100.0% | 0.12% | – |
| AKUS | New | AKOUS INC | $901,000 | – | 45,459 | +100.0% | 0.12% | – |
| New | CATABASIS PHARMACEUTICALS INC | $402,000 | – | 187,750 | +100.0% | 0.05% | – | |
| MGTA | New | MAGENTA THERAPEUTICS INC | $375,000 | – | 47,804 | +100.0% | 0.05% | – |
| AVEO | New | AVEO BIOSCIENCES INC | $339,000 | – | 58,800 | +100.0% | 0.04% | – |
| BLRX | BIOLINERX LTDsponsored ads | $42,000 | +27.3% | 16,667 | 0.0% | 0.01% | -16.7% | |
| PIRS | Exit | PIERIS PHARMACEUTICALS INC | $0 | – | -145,000 | -100.0% | -0.06% | – |
| ONCT | Exit | ONCTERNAL THERAPEUTICS INC | $0 | – | -194,541 | -100.0% | -0.06% | – |
| XFOR | Exit | X4 PHARMACEUTICALS INC | $0 | – | -75,000 | -100.0% | -0.10% | – |
| OM | Exit | OUTSET MED INC | $0 | – | -45,000 | -100.0% | -0.44% | – |
| NERV | Exit | MINERVA NEUROSCIENCES INC | $0 | – | -767,400 | -100.0% | -0.48% | – |
| AGLE | Exit | AEGLEA BIOTHERAPEUTICS INC | $0 | – | -375,000 | -100.0% | -0.52% | – |
| CDTX | Exit | CIDARA THERAPEUTICS INC | $0 | – | -970,664 | -100.0% | -0.54% | – |
| CRNX | Exit | CRINETICS PHARMACEUTICALS INC | $0 | – | -240,000 | -100.0% | -0.74% | – |
| AXGT | Exit | AXOVANT SCIENCES LTD | $0 | – | -2,039,100 | -100.0% | -1.84% | – |
| ATXI | Exit | AVENUE THERAPEUTICS INC | $0 | – | -984,692 | -100.0% | -2.09% | – |
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2021-02-12
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| CODEXIS INC | 39 | Q3 2023 | 10.9% |
| CHIMERIX INC | 31 | Q3 2022 | 16.4% |
| XOMA CORP DEL | 27 | Q3 2023 | 3.6% |
| FIBROGEN INC | 26 | Q1 2021 | 6.8% |
| BIOLINERX LTD (Does not reflect a reverse stock split effectuated after June 30, 2019) | 26 | Q1 2020 | 2.4% |
| OCULAR THERAPEUTIX INC | 24 | Q3 2023 | 17.6% |
| AXOGEN INC | 20 | Q4 2019 | 18.7% |
| ETON PHARMACEUTICALS INC | 20 | Q3 2023 | 5.6% |
| AMARIN CORP PLC | 20 | Q4 2020 | 6.6% |
| IMPRIMIS PHARMACEUTICALS INC | 19 | Q1 2020 | 5.9% |
View Opaleye Management Inc.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| CHIMERIX INCSold out | February 13, 2023 | 0 | 0.0% |
| Larimar Therapeutics, Inc. | January 23, 2023 | 1,560,000 | 3.6% |
| TELA Bio, Inc. | June 10, 2022 | 1,557,500 | 10.7% |
| Gemini Therapeutics, Inc. /DESold out | February 01, 2022 | 0 | 0.0% |
| Adamas Pharmaceuticals IncSold out | January 26, 2022 | 0 | 0.0% |
| AVENUE THERAPEUTICS, INC. | February 12, 2021 | 9 | 11.0% |
| Cardiff Oncology, Inc. | February 12, 2021 | 9 | 11.0% |
| EDAP TMS SA | February 12, 2021 | 9 | 11.0% |
| Fortress Biotech, Inc. | February 12, 2021 | 9 | 11.0% |
| Gemini Therapeutics, Inc. /DE | February 12, 2021 | 9 | 11.0% |
View Opaleye Management Inc.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 4 | 2024-04-25 |
| 4 | 2024-04-24 |
| 4 | 2024-04-19 |
| SC 13G/A | 2024-04-09 |
| SC 13G | 2024-04-08 |
| 4 | 2024-03-28 |
| 4 | 2024-03-22 |
| 13F-HR | 2024-02-14 |
| SC 13G/A | 2024-02-14 |
| SC 13G/A | 2024-02-14 |
View Opaleye Management Inc.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.