$708 Million is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 66 reported holdings in Q1 2022. The portfolio turnover from Q4 2021 to Q1 2022 was 64.4% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| AZN | Sell | ASTRAZENECA PLCsponsored adr | $55,514,000 | -9.7% | 836,817 | -20.7% | 7.85% | +16.1% |
| JNJ | Buy | JOHNSON & JOHNSON | $52,287,000 | +97.0% | 295,023 | +90.2% | 7.39% | +153.3% |
| SNY | Sell | SANOFIsponsored adr | $49,924,000 | -8.0% | 972,415 | -10.2% | 7.06% | +18.2% |
| QQQ | New | INVESCO QQQ TRput | $45,680,000 | – | 126,000 | +100.0% | 6.46% | – |
| ABBV | Sell | ABBVIE INC | $30,962,000 | -50.7% | 190,994 | -58.9% | 4.38% | -36.7% |
| FIVN | Buy | FIVE9 INCcall | $27,479,000 | +12.1% | 248,900 | +39.4% | 3.88% | +44.1% |
| PFE | Buy | PFIZER INC | $26,665,000 | +97.6% | 515,070 | +125.4% | 3.77% | +154.0% |
| NVO | New | NOVO-NORDISK A Sadr | $26,363,000 | – | 237,400 | +100.0% | 3.73% | – |
| SWTX | Buy | SPRINGWORKS THERAPEUTICS INC | $25,964,000 | +22.3% | 460,025 | +34.3% | 3.67% | +57.2% |
| MRK | Sell | MERCK & CO INC | $22,826,000 | -14.0% | 278,200 | -19.7% | 3.23% | +10.5% |
| SNDX | Buy | SYNDAX PHARMACEUTICALS INC | $22,201,000 | -13.8% | 1,277,413 | +8.6% | 3.14% | +10.8% |
| LLY | Sell | LILLY ELI & CO | $20,130,000 | -54.4% | 70,295 | -56.0% | 2.84% | -41.3% |
| TEVA | New | TEVA PHARMACEUTICAL INDS LTDcall | $17,747,000 | – | 1,890,000 | +100.0% | 2.51% | – |
| BMRN | Sell | BIOMARIN PHARMACEUTICAL INC | $16,293,000 | -15.0% | 211,326 | -2.6% | 2.30% | +9.3% |
| KYMR | Buy | KYMERA THERAPEUTICS INC | $15,576,000 | -23.0% | 368,061 | +15.5% | 2.20% | -1.0% |
| ISEE | Buy | IVERIC BIO INC | $13,029,000 | +60.7% | 774,130 | +59.6% | 1.84% | +106.4% |
| GNRC | Buy | GENERAC HLDGS INC | $12,548,000 | -15.2% | 42,211 | +0.4% | 1.77% | +9.0% |
| CRNX | Buy | CRINETICS PHARMACEUTICALS IN | $11,457,000 | -4.7% | 521,947 | +23.3% | 1.62% | +22.5% |
| AMD | New | ADVANCED MICRO DEVICES INC | $10,934,000 | – | 100,000 | +100.0% | 1.54% | – |
| MRUS | Buy | MERUS N V | $10,818,000 | -0.2% | 409,141 | +20.0% | 1.53% | +28.3% |
| ZIM | New | ZIM INTEGRATED SHIPPING SERV | $10,761,000 | – | 148,000 | +100.0% | 1.52% | – |
| KURA | Sell | KURA ONCOLOGY INC | $9,941,000 | -14.7% | 618,244 | -25.7% | 1.40% | +9.7% |
| CCCC | Sell | C4 THERAPEUTICS INC | $8,795,000 | -31.5% | 362,528 | -9.0% | 1.24% | -11.9% |
| KDNY | Buy | CHINOOK THERAPEUTICS INC | $8,077,000 | +343.5% | 493,677 | +342.2% | 1.14% | +471.0% |
| ALT | Buy | ALTIMMUNE INC | $7,959,000 | -30.2% | 1,306,953 | +5.0% | 1.12% | -10.2% |
| RLMD | Sell | RELMADA THERAPEUTICS INC | $7,861,000 | -27.0% | 291,252 | -39.1% | 1.11% | -6.2% |
| TEVA | Buy | TEVA PHARMACEUTICAL INDS LTDsponsored ads | $7,821,000 | +17.2% | 832,878 | +0.0% | 1.10% | +50.8% |
| KROS | Buy | KEROS THERAPEUTICS INC | $7,590,000 | +8.4% | 139,581 | +16.6% | 1.07% | +39.4% |
| SWTX | New | SPRINGWORKS THERAPEUTICS INCcall | $7,055,000 | – | 125,000 | +100.0% | 1.00% | – |
| RUN | SUNRUN INCcall | $6,924,000 | -11.5% | 228,000 | 0.0% | 0.98% | +13.8% | |
| Buy | PERION NETWORK LTD | $6,883,000 | +27.2% | 306,051 | +36.0% | 0.97% | +63.5% | |
| IMUX | Sell | IMMUNIC INC | $6,590,000 | +3.3% | 583,206 | -12.5% | 0.93% | +32.8% |
| VTGN | Buy | VISTAGEN THERAPEUTICS INC | $6,140,000 | -21.8% | 4,951,423 | +23.0% | 0.87% | +0.6% |
| V | New | VISA INC | $5,589,000 | – | 25,200 | +100.0% | 0.79% | – |
| ABNB | Sell | AIRBNB INC | $5,153,000 | -35.1% | 30,000 | -37.1% | 0.73% | -16.6% |
| IMTX | IMMATICS N.V | $4,969,000 | -40.6% | 621,925 | 0.0% | 0.70% | -23.6% | |
| RUN | New | SUNRUN INC | $4,556,000 | – | 150,000 | +100.0% | 0.64% | – |
| CSTE | Sell | CAESARSTONE LTD | $4,503,000 | -38.4% | 428,046 | -33.5% | 0.64% | -20.8% |
| MA | New | MASTERCARD INCORPORATEDcl a | $4,324,000 | – | 12,100 | +100.0% | 0.61% | – |
| Sell | FIVERR INTL LTDnote 11/0 | $4,227,000 | -65.3% | 4,951,000 | -61.9% | 0.60% | -55.4% | |
| New | AIRBNB INCcall | $4,174,000 | – | 24,300 | +100.0% | 0.59% | – | |
| ALNY | New | ALNYLAM PHARMACEUTICALS INC | $4,044,000 | – | 24,768 | +100.0% | 0.57% | – |
| NAUT | Buy | NAUTILUS BIOTECHNOLOGY INC | $3,646,000 | -12.0% | 840,000 | +5.0% | 0.52% | +12.9% |
| REPL | New | REPLIMUNE GROUP INC | $3,611,000 | – | 212,640 | +100.0% | 0.51% | – |
| FATE | Sell | FATE THERAPEUTICS INC | $3,467,000 | -68.1% | 89,425 | -51.8% | 0.49% | -58.9% |
| VRNA | Sell | VERONA PHARMA PLCsponsored ads | $3,325,000 | -38.2% | 666,339 | -16.8% | 0.47% | -20.6% |
| FIVN | Sell | FIVE9 INC | $3,279,000 | -72.1% | 29,699 | -65.3% | 0.46% | -64.2% |
| KZR | Sell | KEZAR LIFE SCIENCES INC | $3,118,000 | -44.7% | 187,599 | -44.4% | 0.44% | -28.9% |
| ASND | New | ASCENDIS PHARMA A/Ssponsored adr | $3,113,000 | – | 26,529 | +100.0% | 0.44% | – |
| IS | New | IRONSOURCE LTD | $2,976,000 | – | 620,000 | +100.0% | 0.42% | – |
| VINC | VINCERX PHARMA INC | $2,881,000 | -60.7% | 720,161 | 0.0% | 0.41% | -49.6% | |
| CAT | New | CATERPILLAR INC | $2,674,000 | – | 12,000 | +100.0% | 0.38% | – |
| HOWL | Sell | WEREWOLF THERAPEUTICS INC | $2,570,000 | -66.7% | 584,203 | -9.9% | 0.36% | -57.2% |
| S | Sell | SENTINELONE INCcl a | $2,518,000 | -75.0% | 65,000 | -67.5% | 0.36% | -67.9% |
| TEVA | New | TEVA PHARMACEUTICAL INDS LTDput | $1,972,000 | – | 210,000 | +100.0% | 0.28% | – |
| KRYS | New | KRYSTAL BIOTECH INC | $1,684,000 | – | 25,310 | +100.0% | 0.24% | – |
| CYCC | CYCLACEL PHARMACEUTICALS INC | $1,550,000 | -21.6% | 508,322 | 0.0% | 0.22% | +0.9% | |
| MGIC | Buy | MAGIC SOFTWARE ENTERPRISES Lord | $1,401,000 | +16.0% | 81,293 | +40.9% | 0.20% | +48.9% |
| LIANBIOsponsored ads | $1,020,000 | -38.6% | 275,007 | 0.0% | 0.14% | -21.3% | ||
| AYLA | AYALA PHARMACEUTICALS INC | $995,000 | -53.2% | 250,000 | 0.0% | 0.14% | -39.7% | |
| ONCR | Sell | ONCORUS INC | $962,000 | -68.0% | 540,258 | -5.4% | 0.14% | -58.9% |
| Sell | OTONOMO TECHNOLOGIES LTDordinary shares | $772,000 | -68.2% | 391,863 | -34.0% | 0.11% | -59.2% | |
| NICE SYS INCnote 1.250% 1/1 | $662,000 | -28.1% | 250,000 | 0.0% | 0.09% | -6.9% | ||
| Sell | OUTBRAIN INC | $564,000 | -90.7% | 52,531 | -87.8% | 0.08% | -88.0% | |
| Sell | ARBE ROBOTICS LTDordinary shares | $300,000 | -73.2% | 43,165 | -64.1% | 0.04% | -65.9% | |
| IMTXW | IMMATICS N.V*w exp 07/01/202 | $175,000 | -60.1% | 100,000 | 0.0% | 0.02% | -47.9% | |
| OTLKW | Exit | OUTLOOK THERAPEUTICS INC*w exp 02/18/202 | $0 | – | -129,500 | -100.0% | -0.00% | – |
| LVTX | Exit | LAVA THERAPEUTICS NV | $0 | – | -137,857 | -100.0% | -0.08% | – |
| VRTX | Exit | VERTEX PHARMACEUTICALS INC | $0 | – | -4,411 | -100.0% | -0.11% | – |
| CYT | Exit | CYTEIR THERAPEUTICS INC | $0 | – | -98,860 | -100.0% | -0.12% | – |
| DYN | Exit | DYNE THERAPEUTICS INC | $0 | – | -105,204 | -100.0% | -0.14% | – |
| ANNX | Exit | ANNEXON INC | $0 | – | -123,637 | -100.0% | -0.16% | – |
| ARGX | Exit | ARGENX SEsponsored adr | $0 | – | -4,291 | -100.0% | -0.16% | – |
| Exit | ARYA SCIENCES ACQUISITN CORP | $0 | – | -200,000 | -100.0% | -0.21% | – | |
| QURE | Exit | UNIQURE NVcall | $0 | – | -100,000 | -100.0% | -0.23% | – |
| BLSA | Exit | BCLS ACQUISITION CORP | $0 | – | -216,250 | -100.0% | -0.23% | – |
| CMPX | Exit | COMPASS THERAPEUTICS INC | $0 | – | -700,000 | -100.0% | -0.24% | – |
| ACET | Exit | ADICET BIO INC | $0 | – | -150,000 | -100.0% | -0.29% | – |
| INBX | Exit | INHIBRX INC | $0 | – | -61,931 | -100.0% | -0.30% | – |
| BIIB | Exit | BIOGEN INC | $0 | – | -13,000 | -100.0% | -0.34% | – |
| TPTX | Exit | TURNING POINT THERAPEUTICS I | $0 | – | -68,734 | -100.0% | -0.36% | – |
| PNT | Exit | POINT BIOPHARMA GLOBAL INC | $0 | – | -592,592 | -100.0% | -0.36% | – |
| CAMT | Exit | CAMTEK LTDord | $0 | – | -75,000 | -100.0% | -0.38% | – |
| BCAB | Exit | BIOATLA INC | $0 | – | -180,006 | -100.0% | -0.39% | – |
| Exit | OMEGA THERAPEUTICS INC | $0 | – | -352,948 | -100.0% | -0.44% | – | |
| ALLT | Exit | ALLOT LTD | $0 | – | -340,912 | -100.0% | -0.44% | – |
| KALV | Exit | KALVISTA PHARMACEUTICALS INC | $0 | – | -316,200 | -100.0% | -0.46% | – |
| STRO | Exit | SUTRO BIOPHARMA INC | $0 | – | -281,702 | -100.0% | -0.46% | – |
| PMVP | Exit | PMV PHARMACEUTICALS INC | $0 | – | -190,525 | -100.0% | -0.48% | – |
| IOVA | Exit | IOVANCE BIOTHERAPEUTICS INC | $0 | – | -281,769 | -100.0% | -0.59% | – |
| IDYA | Exit | IDEAYA BIOSCIENCES INC | $0 | – | -235,695 | -100.0% | -0.61% | – |
| EPIX | Exit | ESSA PHARMA INC | $0 | – | -422,461 | -100.0% | -0.66% | – |
| CLDX | Exit | CELLDEX THERAPEUTICS INC NEW | $0 | – | -166,766 | -100.0% | -0.71% | – |
| ZLAB | Exit | ZAI LAB LTDadr | $0 | – | -111,641 | -100.0% | -0.77% | – |
| ASAN | Exit | ASANA INCcl a | $0 | – | -96,500 | -100.0% | -0.79% | – |
| GRPH | Exit | GRAPHITE BIO INC | $0 | – | -663,194 | -100.0% | -0.91% | – |
| PTGX | Exit | PROTAGONIST THERAPEUTICS INCcall | $0 | – | -250,000 | -100.0% | -0.94% | – |
| LESL | Exit | LESLIES INC | $0 | – | -372,569 | -100.0% | -0.97% | – |
| ARYD | Exit | ARYA SCIENCES ACQU CORP IVcl a | $0 | – | -1,000,000 | -100.0% | -1.09% | – |
| VRNT | Exit | VERINT SYS INC | $0 | – | -200,000 | -100.0% | -1.16% | – |
| BURL | Exit | BURLINGTON STORES INC | $0 | – | -41,501 | -100.0% | -1.33% | – |
| PANW | Exit | PALO ALTO NETWORKS INC | $0 | – | -24,000 | -100.0% | -1.47% | – |
| FB | Exit | META PLATFORMS INCcl a | $0 | – | -41,622 | -100.0% | -1.54% | – |
| AMZN | Exit | AMAZON COM INC | $0 | – | -4,200 | -100.0% | -1.54% | – |
| MSFT | Exit | MICROSOFT CORP | $0 | – | -50,536 | -100.0% | -1.87% | – |
| Exit | WIX COM LTDnote 8/1 | $0 | – | -18,959,000 | -100.0% | -1.91% | – | |
| XBI | Exit | SPDR SER TRcall | $0 | – | -220,000 | -100.0% | -2.71% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2022-05-16
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| TEVA PHARMACEUTICAL-SP ADR | 36 | Q3 2023 | 8.4% |
| MERCK & CO INC NEW | 35 | Q3 2023 | 8.4% |
| NICE Systems Ltd | 27 | Q3 2023 | 4.4% |
| BIOGEN INC | 26 | Q3 2023 | 6.7% |
| AMICUS THERAPEUTICS INC | 26 | Q2 2022 | 4.3% |
| PFIZER INC | 25 | Q3 2023 | 9.2% |
| SAREPTA THERAPEUTICS INC | 25 | Q3 2023 | 3.2% |
| JOHNSON & JOHNSON | 24 | Q3 2023 | 8.0% |
| UNIQURE NV | 23 | Q3 2023 | 1.2% |
| SYNDAX PHARMACEUTICALS INC | 22 | Q3 2023 | 3.9% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Cyclacel Pharmaceuticals, Inc. | February 06, 2023 | 250,000 | 2.0% |
| Altimmune, Inc. | February 14, 2022 | 1,244,241 | 3.1% |
| Allot Ltd. | February 16, 2021 | 1,129,054 | 3.2% |
| Larimar Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Neos Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Orgenesis Inc. | February 16, 2021 | 525,216 | 0.0% |
| Sio Gene Therapies Inc. | February 16, 2021 | ? | ? |
| X4 Pharmaceuticals, Inc | February 16, 2021 | 250,000 | 0.0% |
| Axovant Gene Therapies Ltd. | February 25, 2020 | 2,931,017 | 8.0% |
| Axovant Gene Therapies Ltd. | February 11, 2020 | 398,540 | 1.8% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 13F-HR/A | 2024-02-15 |
| 13F-HR | 2024-02-14 |
| SC 13G | 2024-02-08 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| 13F-HR | 2023-11-14 |
| SC 13G | 2023-10-10 |
| SC 13G | 2023-08-30 |
View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.