$549 Million is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 83 reported holdings in Q3 2023. The portfolio turnover from Q2 2023 to Q3 2023 was 49.4% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| TEVA | Sell | TEVA PHARMACEUTICAL INDS LTDcall | $51,140,759 | -16.6% | 5,013,800 | -38.4% | 9.32% | -2.7% |
| New | INVESCO QQQ TRput | $48,903,854 | – | 136,500 | +100.0% | 8.91% | – | |
| SNY | Sell | SANOFIsponsored adr | $26,793,985 | -6.1% | 499,515 | -5.7% | 4.88% | +9.5% |
| AZN | ASTRAZENECA PLCsponsored adr | $19,304,263 | -5.4% | 285,060 | 0.0% | 3.52% | +10.4% | |
| NICE | Buy | NICE LTDcall | $17,850,000 | +476.3% | 105,000 | +600.0% | 3.25% | +571.7% |
| Buy | ENPHASE ENERGY INCnote 3/0 | $17,329,862 | +29.0% | 20,900,000 | +46.1% | 3.16% | +50.5% | |
| JNJ | Sell | JOHNSON & JOHNSON | $14,769,928 | -25.5% | 94,831 | -20.9% | 2.69% | -13.1% |
| MRK | Buy | MERCK & CO INC | $12,724,620 | -8.6% | 123,600 | +2.5% | 2.32% | +6.7% |
| AMZN | Sell | AMAZON COM INC | $12,114,536 | -25.2% | 95,300 | -23.3% | 2.21% | -12.8% |
| TSEM | Buy | TOWER SEMICONDUCTOR LTD | $11,532,737 | +83.6% | 469,574 | +180.4% | 2.10% | +114.2% |
| SNDX | Buy | SYNDAX PHARMACEUTICALS INC | $11,224,846 | -25.8% | 773,061 | +6.9% | 2.04% | -13.5% |
| MSFT | Buy | MICROSOFT CORP | $10,875,062 | -6.9% | 34,442 | +0.4% | 1.98% | +8.6% |
| RARE | Buy | ULTRAGENYX PHARMACEUTICAL IN | $9,238,163 | +9.0% | 259,135 | +41.1% | 1.68% | +27.2% |
| BBIO | Buy | BRIDGEBIO PHARMA INC | $9,111,811 | +64.7% | 345,537 | +7.4% | 1.66% | +92.1% |
| NVO | Buy | NOVO-NORDISK A Sadr | $8,464,695 | -7.5% | 93,080 | +64.6% | 1.54% | +7.9% |
| PRAX | Sell | PRAXIS PRECISION MEDICINES I | $8,294,042 | -17.7% | 4,850,317 | -44.7% | 1.51% | -4.0% |
| LLY | Sell | ELI LILLY & CO | $7,621,875 | +3.6% | 14,190 | -9.6% | 1.39% | +20.8% |
| MDGL | Buy | MADRIGAL PHARMACEUTICALS INC | $7,428,617 | +28.6% | 50,867 | +103.5% | 1.35% | +50.0% |
| SWTX | Buy | SPRINGWORKS THERAPEUTICS INC | $7,396,342 | -9.8% | 319,911 | +2.3% | 1.35% | +5.2% |
| IMTX | IMMATICS N.V | $7,146,863 | +0.3% | 617,173 | 0.0% | 1.30% | +17.1% | |
| Sell | SHL TELEMEDICINE LTDsponsored ads | $6,956,523 | -12.6% | 632,256 | -11.5% | 1.27% | +1.9% | |
| SEDG | New | SOLAREDGE TECHNOLOGIES INCcall | $6,928,785 | – | 53,500 | +100.0% | 1.26% | – |
| CYTK | New | CYTOKINETICS INC | $6,891,666 | – | 233,933 | +100.0% | 1.26% | – |
| ABBV | Sell | ABBVIE INC | $6,856,760 | -9.1% | 46,000 | -17.9% | 1.25% | +6.0% |
| PANW | Buy | PALO ALTO NETWORKS INC | $6,742,260 | -2.3% | 28,759 | +6.5% | 1.23% | +14.0% |
| BIIB | Buy | BIOGEN INC | $6,642,680 | -2.2% | 25,846 | +8.4% | 1.21% | +14.0% |
| DAWN | DAY ONE BIOPHARMACEUTICALS I | $6,503,100 | +2.8% | 530,000 | 0.0% | 1.18% | +19.9% | |
| KURA | Buy | KURA ONCOLOGY INC | $6,413,977 | +0.5% | 703,287 | +16.6% | 1.17% | +17.2% |
| ALNY | Sell | ALNYLAM PHARMACEUTICALS INC | $6,393,487 | -15.8% | 36,101 | -9.7% | 1.16% | -1.8% |
| NICE | Sell | NICE LTDsponsored adr | $6,371,940 | -64.7% | 37,482 | -57.2% | 1.16% | -58.8% |
| PNT | POINT BIOPHARMA GLOBAL INC | $6,354,122 | -26.4% | 952,642 | 0.0% | 1.16% | -14.2% | |
| TEVA | Sell | TEVA PHARMACEUTICAL INDS LTDsponsored ads | $6,120,000 | -22.6% | 600,000 | -42.9% | 1.12% | -9.7% |
| NVS | NOVARTIS AGsponsored adr | $6,111,600 | +0.9% | 60,000 | 0.0% | 1.11% | +17.8% | |
| SRPT | SAREPTA THERAPEUTICS INC | $6,061,000 | +5.9% | 50,000 | 0.0% | 1.10% | +23.5% | |
| MRUS | Sell | MERUS N V | $5,973,592 | -18.5% | 253,333 | -9.0% | 1.09% | -4.9% |
| Sell | DISC MEDICINE INC | $5,233,478 | -30.9% | 111,398 | -34.7% | 0.95% | -19.4% | |
| INZY | Buy | INOZYME PHARMA INC | $5,186,609 | -17.7% | 1,234,907 | +9.1% | 0.94% | -4.0% |
| AMD | New | ADVANCED MICRO DEVICES INC | $4,968,262 | – | 48,320 | +100.0% | 0.90% | – |
| CLDX | Buy | CELLDEX THERAPEUTICS INC NEW | $4,953,600 | -8.8% | 180,000 | +12.5% | 0.90% | +6.4% |
| ETNB | Buy | 89BIO INC | $4,930,007 | +92.7% | 319,301 | +136.5% | 0.90% | +125.1% |
| PTCT | Buy | PTC THERAPEUTICS INC | $4,895,666 | +20.3% | 218,459 | +118.2% | 0.89% | +40.3% |
| INBX | Buy | INHIBRX INC | $4,704,408 | +262.4% | 256,371 | +412.7% | 0.86% | +322.2% |
| FB | New | META PLATFORMS INCcl a | $4,569,196 | – | 15,220 | +100.0% | 0.83% | – |
| GRCL | Buy | GRACELL BIOTECHNOLOGIES INCsponsored ads | $4,410,711 | -5.8% | 1,531,497 | +24.6% | 0.80% | +9.8% |
| Buy | MINERALYS THERAPEUTICS INC | $4,330,854 | -37.3% | 455,400 | +12.3% | 0.79% | -26.9% | |
| Buy | ASTRIA THERAPEUTICS INC | $4,331,269 | +10.4% | 580,599 | +23.3% | 0.79% | +28.7% | |
| RCKT | Sell | ROCKET PHARMACEUTICALS INC | $4,283,230 | -8.7% | 209,040 | -11.4% | 0.78% | +6.6% |
| COGT | COGENT BIOSCIENCES INC | $4,095,000 | -17.7% | 420,000 | 0.0% | 0.75% | -3.9% | |
| Buy | JASPER THERAPEUTICS INC | $3,980,994 | -32.0% | 5,687,134 | +33.1% | 0.72% | -20.7% | |
| New | PROMIS NEUROSCIENCES INC | $3,686,424 | – | 1,834,042 | +100.0% | 0.67% | – | |
| XBI | SPDR SER TRs&p biotech | $3,651,000 | -12.2% | 50,000 | 0.0% | 0.66% | +2.3% | |
| GSK PLCsponsored adr | $3,625,000 | +1.7% | 100,000 | 0.0% | 0.66% | +18.7% | ||
| MIRM | New | MIRUM PHARMACEUTICALS INC | $3,611,374 | – | 114,284 | +100.0% | 0.66% | – |
| Buy | AMYLYX PHARMACEUTICALS INC | $3,545,732 | +64.4% | 193,650 | +93.6% | 0.65% | +91.7% | |
| FUSN | Buy | FUSION PHARMACEUTICALS INC | $3,521,071 | -43.3% | 1,354,258 | +1.9% | 0.64% | -33.8% |
| REPL | New | REPLIMUNE GROUP INC | $3,165,624 | – | 185,016 | +100.0% | 0.58% | – |
| GILD | GILEAD SCIENCES INC | $2,997,600 | -2.8% | 40,000 | 0.0% | 0.55% | +13.5% | |
| PFE | Sell | PFIZER INC | $2,985,300 | -41.9% | 90,000 | -35.7% | 0.54% | -32.2% |
| XENE | New | XENON PHARMACEUTICALS INCput | $2,814,784 | – | 82,400 | +100.0% | 0.51% | – |
| CLDX | New | CELLDEX THERAPEUTICS INC NEWcall | $2,752,000 | – | 100,000 | +100.0% | 0.50% | – |
| PLRX | New | PLIANT THERAPEUTICS INC | $2,707,364 | – | 156,134 | +100.0% | 0.49% | – |
| ICL | New | ICL GROUP LTD | $2,608,500 | – | 470,000 | +100.0% | 0.48% | – |
| CRWD | New | CROWDSTRIKE HLDGS INCcl a | $2,510,700 | – | 15,000 | +100.0% | 0.46% | – |
| KZR | Buy | KEZAR LIFE SCIENCES INC | $2,441,494 | -49.9% | 2,051,676 | +3.2% | 0.44% | -41.5% |
| MORF | MORPHIC HLDG INC | $2,061,900 | -60.0% | 90,000 | 0.0% | 0.38% | -53.3% | |
| ALPN | Sell | ALPINE IMMUNE SCIENCES INC | $2,061,000 | +0.2% | 180,000 | -10.0% | 0.38% | +16.8% |
| CYTK | New | CYTOKINETICS INCcall | $1,914,900 | – | 65,000 | +100.0% | 0.35% | – |
| GOSS | New | GOSSAMER BIO INC | $1,609,443 | – | 1,932,568 | +100.0% | 0.29% | – |
| VERA | VERA THERAPEUTICS INCcl a | $1,439,550 | -14.6% | 105,000 | 0.0% | 0.26% | -0.4% | |
| HOWL | WEREWOLF THERAPEUTICS INC | $1,341,373 | -29.8% | 626,810 | 0.0% | 0.24% | -18.4% | |
| RIGL | RIGEL PHARMACEUTICALS INC | $1,326,376 | -16.3% | 1,228,126 | 0.0% | 0.24% | -2.0% | |
| XENE | New | XENON PHARMACEUTICALS INC | $1,330,839 | – | 38,959 | +100.0% | 0.24% | – |
| RZLT | Sell | REZOLUTE INC | $1,315,657 | -42.5% | 996,710 | -13.8% | 0.24% | -32.8% |
| CGEN | Buy | COMPUGEN LTDord | $1,226,892 | -12.5% | 1,319,239 | +7.3% | 0.22% | +1.8% |
| Sell | MEDIWOUND LTD | $1,154,791 | -2.5% | 108,533 | -2.3% | 0.21% | +13.5% | |
| QURE | UNIQURE NV | $998,005 | -41.4% | 148,734 | 0.0% | 0.18% | -31.6% | |
| SELB | Sell | SELECTA BIOSCIENCES INC | $797,265 | -65.1% | 752,137 | -63.1% | 0.14% | -59.3% |
| New | APOGEE THERAPEUTICS INC | $639,000 | – | 30,000 | +100.0% | 0.12% | – | |
| ELEV | ELEVATION ONCOLOGY INC | $596,340 | -56.4% | 900,000 | 0.0% | 0.11% | -49.1% | |
| New | VISTAGEN THERAPEUTICS INC | $524,000 | – | 100,000 | +100.0% | 0.10% | – | |
| IMTXW | IMMATICS N.V*w exp 07/01/202 | $354,000 | +3.5% | 100,000 | 0.0% | 0.06% | +20.8% | |
| CALT | New | CALLIDITAS THERAPEUTICS ABsponsered ads | $216,618 | – | 11,863 | +100.0% | 0.04% | – |
| Exit | ARBE ROBOTICS LTDordinary shares | $0 | – | -43,165 | -100.0% | -0.02% | – | |
| CYCC | Exit | CYCLACEL PHARMACEUTICALS INC | $0 | – | -250,000 | -100.0% | -0.02% | – |
| INFI | Exit | INFINITY PHARMACEUTICALS INC | $0 | – | -1,476,000 | -100.0% | -0.05% | – |
| PMVP | Exit | PMV PHARMACEUTICALS INC | $0 | – | -187,800 | -100.0% | -0.18% | – |
| DYN | Exit | DYNE THERAPEUTICS INC | $0 | – | -119,918 | -100.0% | -0.21% | – |
| MRSN | Exit | MERSANA THERAPEUTICS INC | $0 | – | -418,562 | -100.0% | -0.22% | – |
| ALT | Exit | ALTIMMUNE INC | $0 | – | -500,000 | -100.0% | -0.28% | – |
| BBIO | Exit | BRIDGEBIO PHARMA INCcall | $0 | – | -130,000 | -100.0% | -0.35% | – |
| Exit | ARCELLX INC | $0 | – | -77,488 | -100.0% | -0.38% | – | |
| TVTX | Exit | TRAVERE THERAPEUTICS INC | $0 | – | -213,462 | -100.0% | -0.51% | – |
| Exit | ENLIGHT RENEWABLE ENERGY LTD | $0 | – | -211,586 | -100.0% | -0.59% | – | |
| QCOM | Exit | QUALCOMM INC | $0 | – | -32,000 | -100.0% | -0.60% | – |
| ARGX | Exit | ARGENX SEput | $0 | – | -10,000 | -100.0% | -0.61% | – |
| ISEE | Exit | IVERIC BIO INC | $0 | – | -134,414 | -100.0% | -0.83% | – |
| SAGE | Exit | SAGE THERAPEUTICS INC | $0 | – | -128,000 | -100.0% | -0.94% | – |
| ENPH | Exit | ENPHASE ENERGY INCcall | $0 | – | -40,000 | -100.0% | -1.05% | – |
| CAMT | Exit | CAMTEK LTDord | $0 | – | -189,494 | -100.0% | -1.05% | – |
| MSFT | Exit | MICROSOFT CORPcall | $0 | – | -21,000 | -100.0% | -1.12% | – |
| GNRC | Exit | GENERAC HLDGS INCcall | $0 | – | -52,500 | -100.0% | -1.22% | – |
| NVMI | Exit | NOVA LTD | $0 | – | -70,000 | -100.0% | -1.28% | – |
| SRPT | Exit | SAREPTA THERAPEUTICS INCcall | $0 | – | -78,300 | -100.0% | -1.40% | – |
| TSEM | Exit | TOWER SEMICONDUCTOR LTDput | $0 | – | -332,100 | -100.0% | -1.95% | – |
| AMD | Exit | ADVANCED MICRO DEVICES INCcall | $0 | – | -120,000 | -100.0% | -2.13% | – |
| QQQ | Exit | INVESCO QQQ TRput | $0 | – | -126,000 | -100.0% | -7.27% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2023-11-14
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| TEVA PHARMACEUTICAL-SP ADR | 36 | Q3 2023 | 8.4% |
| MERCK & CO INC NEW | 35 | Q3 2023 | 8.4% |
| NICE Systems Ltd | 27 | Q3 2023 | 4.4% |
| BIOGEN INC | 26 | Q3 2023 | 6.7% |
| AMICUS THERAPEUTICS INC | 26 | Q2 2022 | 4.3% |
| PFIZER INC | 25 | Q3 2023 | 9.2% |
| SAREPTA THERAPEUTICS INC | 25 | Q3 2023 | 3.2% |
| JOHNSON & JOHNSON | 24 | Q3 2023 | 8.0% |
| UNIQURE NV | 23 | Q3 2023 | 1.2% |
| SYNDAX PHARMACEUTICALS INC | 22 | Q3 2023 | 3.9% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Cyclacel Pharmaceuticals, Inc. | February 06, 2023 | 250,000 | 2.0% |
| Altimmune, Inc. | February 14, 2022 | 1,244,241 | 3.1% |
| Allot Ltd. | February 16, 2021 | 1,129,054 | 3.2% |
| Larimar Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Neos Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Orgenesis Inc. | February 16, 2021 | 525,216 | 0.0% |
| Sio Gene Therapies Inc. | February 16, 2021 | ? | ? |
| X4 Pharmaceuticals, Inc | February 16, 2021 | 250,000 | 0.0% |
| Axovant Gene Therapies Ltd. | February 25, 2020 | 2,931,017 | 8.0% |
| Axovant Gene Therapies Ltd. | February 11, 2020 | 398,540 | 1.8% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 13F-HR/A | 2024-02-15 |
| 13F-HR | 2024-02-14 |
| SC 13G | 2024-02-08 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| 13F-HR | 2023-11-14 |
| SC 13G | 2023-10-10 |
| SC 13G | 2023-08-30 |
View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.