$935 Million is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 57 reported holdings in Q2 2022. The portfolio turnover from Q1 2022 to Q2 2022 was 74.2% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| QQQ | New | INVESCO QQQ TRcall | $278,262,000 | – | 992,800 | +100.0% | 29.76% | – |
| SPY | New | SPDR S&P 500 ETF TRcall | $75,261,000 | – | 199,500 | +100.0% | 8.05% | – |
| AZN | Sell | ASTRAZENECA PLCsponsored adr | $52,764,000 | -5.0% | 798,610 | -4.6% | 5.64% | -28.1% |
| JNJ | Sell | JOHNSON & JOHNSON | $49,073,000 | -6.1% | 276,451 | -6.3% | 5.25% | -29.0% |
| LLY | Buy | LILLY ELI & CO | $42,879,000 | +113.0% | 132,250 | +88.1% | 4.59% | +61.2% |
| SNY | Sell | SANOFIsponsored adr | $42,336,000 | -15.2% | 846,215 | -13.0% | 4.53% | -35.8% |
| ABBV | Buy | ABBVIE INC | $33,448,000 | +8.0% | 218,385 | +14.3% | 3.58% | -18.2% |
| XBI | New | SPDR SER TRs&p biotech | $32,512,000 | – | 437,748 | +100.0% | 3.48% | – |
| NVO | Buy | NOVO-NORDISK A Sadr | $29,132,000 | +10.5% | 261,440 | +10.1% | 3.12% | -16.4% |
| MRK | Buy | MERCK & CO INC | $25,983,000 | +13.8% | 285,000 | +2.4% | 2.78% | -13.9% |
| TEVA | Buy | TEVA PHARMACEUTICAL INDS LTDcall | $25,430,000 | +43.3% | 3,381,600 | +78.9% | 2.72% | +8.5% |
| SNDX | Sell | SYNDAX PHARMACEUTICALS INC | $21,921,000 | -1.3% | 1,139,329 | -10.8% | 2.34% | -25.3% |
| ALT | Buy | ALTIMMUNE INC | $16,297,000 | +104.8% | 1,392,884 | +6.6% | 1.74% | +54.9% |
| XBI | New | SPDR SER TRcall | $14,854,000 | – | 200,000 | +100.0% | 1.59% | – |
| SWTX | Buy | SPRINGWORKS THERAPEUTICS INC | $13,213,000 | -49.1% | 536,664 | +16.7% | 1.41% | -61.5% |
| FIVN | Buy | FIVE9 INC | $12,848,000 | +291.8% | 140,968 | +374.7% | 1.37% | +196.8% |
| KDNY | Buy | CHINOOK THERAPEUTICS INC | $11,259,000 | +39.4% | 643,731 | +30.4% | 1.20% | +5.4% |
| CRNX | Buy | CRINETICS PHARMACEUTICALS IN | $10,944,000 | -4.5% | 586,820 | +12.4% | 1.17% | -27.7% |
| ALNY | New | ALNYLAM PHARMACEUTICALS INCcall | $10,939,000 | – | 75,000 | +100.0% | 1.17% | – |
| NICE | New | NICE LTDsponsored adr | $10,678,000 | – | 55,482 | +100.0% | 1.14% | – |
| MRUS | Buy | MERUS N V | $9,263,000 | -14.4% | 409,161 | +0.0% | 0.99% | -35.2% |
| ISEE | Buy | IVERIC BIO INC | $9,259,000 | -28.9% | 962,470 | +24.3% | 0.99% | -46.2% |
| KURA | Sell | KURA ONCOLOGY INC | $9,066,000 | -8.8% | 494,595 | -20.0% | 0.97% | -31.0% |
| RLMD | Buy | RELMADA THERAPEUTICS INC | $8,865,000 | +12.8% | 466,830 | +60.3% | 0.95% | -14.7% |
| TEVA | Buy | TEVA PHARMACEUTICAL INDS LTDsponsored ads | $8,632,000 | +10.4% | 1,147,878 | +37.8% | 0.92% | -16.5% |
| FOLD | New | AMICUS THERAPEUTICS INC | $8,088,000 | – | 753,037 | +100.0% | 0.86% | – |
| FB | New | META PLATFORMS INCcl a | $8,063,000 | – | 50,000 | +100.0% | 0.86% | – |
| IMTX | Buy | IMMATICS N.V | $6,365,000 | +28.1% | 730,712 | +17.5% | 0.68% | -3.0% |
| INZY | New | INOZYME PHARMA INC | $5,560,000 | – | 1,165,600 | +100.0% | 0.60% | – |
| CCCC | Buy | C4 THERAPEUTICS INC | $5,321,000 | -39.5% | 705,736 | +94.7% | 0.57% | -54.2% |
| FIVERR INTL LTDnote 11/0 | $3,786,000 | -10.4% | 4,951,000 | 0.0% | 0.40% | -32.2% | ||
| RZLT | New | REZOLUTE INC | $3,734,000 | – | 1,155,897 | +100.0% | 0.40% | – |
| VTGN | Sell | VISTAGEN THERAPEUTICS INC | $2,896,000 | -52.8% | 3,291,135 | -33.5% | 0.31% | -64.3% |
| CNCE | New | CONCERT PHARMACEUTICALS INC | $2,860,000 | – | 679,400 | +100.0% | 0.31% | – |
| RIGL | New | RIGEL PHARMACEUTICALS INC | $2,853,000 | – | 2,525,000 | +100.0% | 0.30% | – |
| PMVP | New | PMV PHARMACEUTICALS INC | $2,676,000 | – | 187,800 | +100.0% | 0.29% | – |
| V | Sell | VISA INC | $2,481,000 | -55.6% | 12,600 | -50.0% | 0.26% | -66.5% |
| KZR | Buy | KEZAR LIFE SCIENCES INC | $2,478,000 | -20.5% | 299,654 | +59.7% | 0.26% | -39.9% |
| ABNB | Sell | AIRBNB INC | $2,468,000 | -52.1% | 27,700 | -7.7% | 0.26% | -63.7% |
| HOWL | Buy | WEREWOLF THERAPEUTICS INC | $2,442,000 | -5.0% | 597,003 | +2.2% | 0.26% | -28.1% |
| QQQ | New | INVESCO QQQ TRunit ser 1 | $2,294,000 | – | 8,186 | +100.0% | 0.24% | – |
| ISEE | New | IVERIC BIO INCcall | $1,924,000 | – | 200,000 | +100.0% | 0.21% | – |
| KROS | Sell | KEROS THERAPEUTICS INC | $1,879,000 | -75.2% | 67,997 | -51.3% | 0.20% | -81.3% |
| NVDA | New | NVIDIA CORPORATION | $1,711,000 | – | 11,288 | +100.0% | 0.18% | – |
| MGIC | MAGIC SOFTWARE ENTERPRISES Lord | $1,445,000 | +3.1% | 81,293 | 0.0% | 0.16% | -21.7% | |
| ETNB | New | 89BIO INC | $1,449,000 | – | 450,000 | +100.0% | 0.16% | – |
| VTGN | New | VISTAGEN THERAPEUTICS INCcall | $1,320,000 | – | 1,500,000 | +100.0% | 0.14% | – |
| AMD | Sell | ADVANCED MICRO DEVICES INC | $1,206,000 | -89.0% | 15,773 | -84.2% | 0.13% | -91.7% |
| KNTE | New | KINNATE BIOPHARMA INC | $1,156,000 | – | 91,673 | +100.0% | 0.12% | – |
| ONCR | ONCORUS INC | $681,000 | -29.2% | 540,258 | 0.0% | 0.07% | -46.3% | |
| NICE SYS INCnote 1.250% 1/1 | $588,000 | -11.2% | 250,000 | 0.0% | 0.06% | -33.0% | ||
| New | WIX COM LTDnote 8/1 | $566,000 | – | 700,000 | +100.0% | 0.06% | – | |
| GNRC | Sell | GENERAC HLDGS INC | $486,000 | -96.1% | 2,310 | -94.5% | 0.05% | -97.1% |
| OTONOMO TECHNOLOGIES LTDordinary shares | $431,000 | -44.2% | 391,863 | 0.0% | 0.05% | -57.8% | ||
| ARBE ROBOTICS LTDordinary shares | $237,000 | -21.0% | 43,165 | 0.0% | 0.02% | -40.5% | ||
| IMTXW | IMMATICS N.V*w exp 07/01/202 | $204,000 | +16.6% | 100,000 | 0.0% | 0.02% | -12.0% | |
| VINC | Sell | VINCERX PHARMA INC | $93,000 | -96.8% | 70,467 | -90.2% | 0.01% | -97.5% |
| Exit | OUTBRAIN INC | $0 | – | -52,531 | -100.0% | -0.08% | – | |
| AYLA | Exit | AYALA PHARMACEUTICALS INC | $0 | – | -250,000 | -100.0% | -0.14% | – |
| Exit | LIANBIOsponsored ads | $0 | – | -275,007 | -100.0% | -0.14% | – | |
| CYCC | Exit | CYCLACEL PHARMACEUTICALS INC | $0 | – | -508,322 | -100.0% | -0.22% | – |
| KRYS | Exit | KRYSTAL BIOTECH INC | $0 | – | -25,310 | -100.0% | -0.24% | – |
| TEVA | Exit | TEVA PHARMACEUTICAL INDS LTDput | $0 | – | -210,000 | -100.0% | -0.28% | – |
| S | Exit | SENTINELONE INCcl a | $0 | – | -65,000 | -100.0% | -0.36% | – |
| CAT | Exit | CATERPILLAR INC | $0 | – | -12,000 | -100.0% | -0.38% | – |
| IS | Exit | IRONSOURCE LTD | $0 | – | -620,000 | -100.0% | -0.42% | – |
| ASND | Exit | ASCENDIS PHARMA A/Ssponsored adr | $0 | – | -26,529 | -100.0% | -0.44% | – |
| VRNA | Exit | VERONA PHARMA PLCsponsored ads | $0 | – | -666,339 | -100.0% | -0.47% | – |
| FATE | Exit | FATE THERAPEUTICS INC | $0 | – | -89,425 | -100.0% | -0.49% | – |
| REPL | Exit | REPLIMUNE GROUP INC | $0 | – | -212,640 | -100.0% | -0.51% | – |
| NAUT | Exit | NAUTILUS BIOTECHNOLOGY INC | $0 | – | -840,000 | -100.0% | -0.52% | – |
| ALNY | Exit | ALNYLAM PHARMACEUTICALS INC | $0 | – | -24,768 | -100.0% | -0.57% | – |
| Exit | AIRBNB INCcall | $0 | – | -24,300 | -100.0% | -0.59% | – | |
| MA | Exit | MASTERCARD INCORPORATEDcl a | $0 | – | -12,100 | -100.0% | -0.61% | – |
| CSTE | Exit | CAESARSTONE LTD | $0 | – | -428,046 | -100.0% | -0.64% | – |
| RUN | Exit | SUNRUN INC | $0 | – | -150,000 | -100.0% | -0.64% | – |
| IMUX | Exit | IMMUNIC INC | $0 | – | -583,206 | -100.0% | -0.93% | – |
| Exit | PERION NETWORK LTD | $0 | – | -306,051 | -100.0% | -0.97% | – | |
| RUN | Exit | SUNRUN INCcall | $0 | – | -228,000 | -100.0% | -0.98% | – |
| SWTX | Exit | SPRINGWORKS THERAPEUTICS INCcall | $0 | – | -125,000 | -100.0% | -1.00% | – |
| ZIM | Exit | ZIM INTEGRATED SHIPPING SERV | $0 | – | -148,000 | -100.0% | -1.52% | – |
| KYMR | Exit | KYMERA THERAPEUTICS INC | $0 | – | -368,061 | -100.0% | -2.20% | – |
| BMRN | Exit | BIOMARIN PHARMACEUTICAL INC | $0 | – | -211,326 | -100.0% | -2.30% | – |
| PFE | Exit | PFIZER INC | $0 | – | -515,070 | -100.0% | -3.77% | – |
| FIVN | Exit | FIVE9 INCcall | $0 | – | -248,900 | -100.0% | -3.88% | – |
| QQQ | Exit | INVESCO QQQ TRput | $0 | – | -126,000 | -100.0% | -6.46% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2022-08-15
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| TEVA PHARMACEUTICAL-SP ADR | 36 | Q3 2023 | 8.4% |
| MERCK & CO INC NEW | 35 | Q3 2023 | 8.4% |
| NICE Systems Ltd | 27 | Q3 2023 | 4.4% |
| BIOGEN INC | 26 | Q3 2023 | 6.7% |
| AMICUS THERAPEUTICS INC | 26 | Q2 2022 | 4.3% |
| PFIZER INC | 25 | Q3 2023 | 9.2% |
| SAREPTA THERAPEUTICS INC | 25 | Q3 2023 | 3.2% |
| JOHNSON & JOHNSON | 24 | Q3 2023 | 8.0% |
| UNIQURE NV | 23 | Q3 2023 | 1.2% |
| SYNDAX PHARMACEUTICALS INC | 22 | Q3 2023 | 3.9% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Cyclacel Pharmaceuticals, Inc. | February 06, 2023 | 250,000 | 2.0% |
| Altimmune, Inc. | February 14, 2022 | 1,244,241 | 3.1% |
| Allot Ltd. | February 16, 2021 | 1,129,054 | 3.2% |
| Larimar Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Neos Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Orgenesis Inc. | February 16, 2021 | 525,216 | 0.0% |
| Sio Gene Therapies Inc. | February 16, 2021 | ? | ? |
| X4 Pharmaceuticals, Inc | February 16, 2021 | 250,000 | 0.0% |
| Axovant Gene Therapies Ltd. | February 25, 2020 | 2,931,017 | 8.0% |
| Axovant Gene Therapies Ltd. | February 11, 2020 | 398,540 | 1.8% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 13F-HR/A | 2024-02-15 |
| 13F-HR | 2024-02-14 |
| SC 13G | 2024-02-08 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| 13F-HR | 2023-11-14 |
| SC 13G | 2023-10-10 |
| SC 13G | 2023-08-30 |
View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.