$910 Million is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 90 reported holdings in Q4 2021. The portfolio turnover from Q3 2021 to Q4 2021 was 65.5% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| ABBV | Sell | ABBVIE INC | $62,852,000 | -2.3% | 464,194 | -22.2% | 6.91% | +27.9% |
| AZN | Sell | ASTRAZENECA PLCsponsored adr | $61,481,000 | -20.7% | 1,055,467 | -18.3% | 6.76% | +3.7% |
| SNY | Buy | SANOFIsponsored adr | $54,278,000 | +33.5% | 1,083,400 | +28.5% | 5.97% | +74.7% |
| LLY | Sell | LILLY ELI & CO | $44,111,000 | -45.2% | 159,695 | -54.2% | 4.85% | -28.3% |
| MRK | New | MERCK & CO INC | $26,550,000 | – | 346,423 | +100.0% | 2.92% | – |
| JNJ | Sell | JOHNSON & JOHNSON | $26,537,000 | -31.2% | 155,123 | -35.1% | 2.92% | -10.0% |
| SNDX | Buy | SYNDAX PHARMACEUTICALS INC | $25,755,000 | +79.6% | 1,176,585 | +56.8% | 2.83% | +135.0% |
| XBI | New | SPDR SER TRcall | $24,631,000 | – | 220,000 | +100.0% | 2.71% | – |
| FIVN | New | FIVE9 INCcall | $24,512,000 | – | 178,500 | +100.0% | 2.70% | – |
| SWTX | Buy | SPRINGWORKS THERAPEUTICS INC | $21,232,000 | +35.0% | 342,566 | +38.2% | 2.33% | +76.7% |
| KYMR | Sell | KYMERA THERAPEUTICS INC | $20,232,000 | -4.1% | 318,667 | -11.3% | 2.22% | +25.4% |
| BMRN | Buy | BIOMARIN PHARMACEUTICAL INC | $19,170,000 | +66.4% | 216,977 | +45.6% | 2.11% | +117.8% |
| Buy | WIX COM LTDnote 8/1 | $17,337,000 | +61.7% | 18,959,000 | +70.8% | 1.91% | +111.5% | |
| MSFT | Sell | MICROSOFT CORP | $16,996,000 | -10.7% | 50,536 | -25.2% | 1.87% | +16.8% |
| GNRC | Sell | GENERAC HLDGS INC | $14,801,000 | -49.0% | 42,057 | -40.8% | 1.63% | -33.3% |
| AMZN | Buy | AMAZON COM INC | $14,004,000 | +2547.3% | 4,200 | +2508.7% | 1.54% | +3400.0% |
| FB | Buy | META PLATFORMS INCcl a | $14,000,000 | +19.9% | 41,622 | +21.0% | 1.54% | +56.9% |
| PFE | Sell | PFIZER INC | $13,495,000 | -71.6% | 228,528 | -79.3% | 1.48% | -62.9% |
| PANW | Sell | PALO ALTO NETWORKS INC | $13,362,000 | -10.0% | 24,000 | -22.6% | 1.47% | +17.7% |
| CCCC | Buy | C4 THERAPEUTICS INC | $12,831,000 | -24.8% | 398,469 | +4.4% | 1.41% | -1.5% |
| New | FIVERR INTL LTDnote 11/0 | $12,175,000 | – | 13,000,000 | +100.0% | 1.34% | – | |
| BURL | New | BURLINGTON STORES INC | $12,098,000 | – | 41,501 | +100.0% | 1.33% | – |
| CRNX | Sell | CRINETICS PHARMACEUTICALS IN | $12,024,000 | +4.1% | 423,248 | -22.9% | 1.32% | +36.3% |
| FIVN | New | FIVE9 INC | $11,749,000 | – | 85,556 | +100.0% | 1.29% | – |
| KURA | Buy | KURA ONCOLOGY INC | $11,651,000 | -21.1% | 832,238 | +5.5% | 1.28% | +3.2% |
| ALT | Buy | ALTIMMUNE INC | $11,397,000 | -7.5% | 1,244,241 | +14.3% | 1.25% | +21.1% |
| FATE | Sell | FATE THERAPEUTICS INC | $10,852,000 | -16.5% | 185,476 | -15.4% | 1.19% | +9.2% |
| MRUS | Buy | MERUS N V | $10,842,000 | +59.3% | 340,951 | +10.2% | 1.19% | +108.4% |
| RLMD | New | RELMADA THERAPEUTICS INC | $10,774,000 | – | 478,208 | +100.0% | 1.18% | – |
| VRNT | Buy | VERINT SYS INC | $10,502,000 | +56.3% | 200,000 | +33.3% | 1.16% | +104.8% |
| S | New | SENTINELONE INCcl a | $10,089,000 | – | 199,824 | +100.0% | 1.11% | – |
| ARYD | ARYA SCIENCES ACQU CORP IVcl a | $9,930,000 | -1.3% | 1,000,000 | 0.0% | 1.09% | +29.2% | |
| LESL | Buy | LESLIES INC | $8,815,000 | +186.1% | 372,569 | +148.4% | 0.97% | +274.1% |
| PTGX | PROTAGONIST THERAPEUTICS INCcall | $8,550,000 | +93.0% | 250,000 | 0.0% | 0.94% | +152.7% | |
| IMTX | Sell | IMMATICS N.V | $8,359,000 | -19.6% | 621,925 | -22.3% | 0.92% | +5.1% |
| GRPH | Buy | GRAPHITE BIO INC | $8,244,000 | -5.3% | 663,194 | +24.8% | 0.91% | +23.8% |
| ISEE | IVERIC BIO INC | $8,109,000 | +3.0% | 485,001 | 0.0% | 0.89% | +34.7% | |
| ABNB | New | AIRBNB INC | $7,940,000 | – | 47,689 | +100.0% | 0.87% | – |
| VTGN | Buy | VISTAGEN THERAPEUTICS INC | $7,849,000 | -25.1% | 4,024,938 | +5.2% | 0.86% | -1.9% |
| RUN | New | SUNRUN INCcall | $7,820,000 | – | 228,000 | +100.0% | 0.86% | – |
| HOWL | Sell | WEREWOLF THERAPEUTICS INC | $7,722,000 | -34.6% | 648,391 | -5.8% | 0.85% | -14.5% |
| VINC | Buy | VINCERX PHARMA INC | $7,338,000 | -30.7% | 720,161 | +10.0% | 0.81% | -9.2% |
| CSTE | CAESARSTONE LTD | $7,305,000 | -8.7% | 644,146 | 0.0% | 0.80% | +19.5% | |
| ASAN | New | ASANA INCcl a | $7,194,000 | – | 96,500 | +100.0% | 0.79% | – |
| ZLAB | Sell | ZAI LAB LTDadr | $7,017,000 | -54.4% | 111,641 | -23.5% | 0.77% | -40.4% |
| KROS | New | KEROS THERAPEUTICS INC | $7,003,000 | – | 119,681 | +100.0% | 0.77% | – |
| TEVA | Sell | TEVA PHARMACEUTICAL INDS LTDsponsored ads | $6,671,000 | -17.8% | 832,877 | -0.0% | 0.73% | +7.5% |
| CLDX | Buy | CELLDEX THERAPEUTICS INC NEW | $6,444,000 | -8.4% | 166,766 | +28.0% | 0.71% | +19.8% |
| IMUX | Buy | IMMUNIC INC | $6,379,000 | +84.9% | 666,602 | +71.0% | 0.70% | +141.7% |
| OUTBRAIN INC | $6,037,000 | -5.4% | 431,194 | 0.0% | 0.66% | +23.9% | ||
| EPIX | Sell | ESSA PHARMA INC | $5,999,000 | +59.8% | 422,461 | -10.0% | 0.66% | +109.5% |
| KZR | New | KEZAR LIFE SCIENCES INC | $5,640,000 | – | 337,293 | +100.0% | 0.62% | – |
| IDYA | Sell | IDEAYA BIOSCIENCES INC | $5,572,000 | -25.8% | 235,695 | -20.0% | 0.61% | -2.9% |
| New | PERION NETWORK LTD | $5,411,000 | – | 225,000 | +100.0% | 0.60% | – | |
| VRNA | VERONA PHARMA PLCsponsored ads | $5,384,000 | +22.6% | 801,256 | 0.0% | 0.59% | +60.4% | |
| IOVA | Sell | IOVANCE BIOTHERAPEUTICS INC | $5,379,000 | -55.9% | 281,769 | -43.1% | 0.59% | -42.3% |
| PMVP | PMV PHARMACEUTICALS INC | $4,401,000 | -22.5% | 190,525 | 0.0% | 0.48% | +1.5% | |
| STRO | Sell | SUTRO BIOPHARMA INC | $4,192,000 | -24.7% | 281,702 | -4.5% | 0.46% | -1.5% |
| KALV | New | KALVISTA PHARMACEUTICALS INC | $4,183,000 | – | 316,200 | +100.0% | 0.46% | – |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | $4,144,000 | -15.6% | 800,000 | 0.0% | 0.46% | +10.4% | |
| ALLT | Sell | ALLOT LTD | $4,050,000 | -20.1% | 340,912 | -0.0% | 0.44% | +4.5% |
| Sell | OMEGA THERAPEUTICS INC | $3,999,000 | -59.8% | 352,948 | -33.1% | 0.44% | -47.4% | |
| BCAB | Sell | BIOATLA INC | $3,534,000 | -44.0% | 180,006 | -16.0% | 0.39% | -26.6% |
| CAMT | New | CAMTEK LTDord | $3,453,000 | – | 75,000 | +100.0% | 0.38% | – |
| PNT | Sell | POINT BIOPHARMA GLOBAL INC | $3,319,000 | -41.6% | 592,592 | -19.8% | 0.36% | -23.6% |
| TPTX | New | TURNING POINT THERAPEUTICS I | $3,279,000 | – | 68,734 | +100.0% | 0.36% | – |
| BIIB | New | BIOGEN INC | $3,119,000 | – | 13,000 | +100.0% | 0.34% | – |
| ONCR | Sell | ONCORUS INC | $3,010,000 | -63.4% | 571,204 | -35.1% | 0.33% | -52.1% |
| INBX | Sell | INHIBRX INC | $2,705,000 | -73.8% | 61,931 | -80.0% | 0.30% | -65.8% |
| ACET | New | ADICET BIO INC | $2,624,000 | – | 150,000 | +100.0% | 0.29% | – |
| Sell | OTONOMO TECHNOLOGIES LTDordinary shares | $2,428,000 | -15.3% | 593,650 | -1.1% | 0.27% | +10.8% | |
| CMPX | New | COMPASS THERAPEUTICS INC | $2,219,000 | – | 700,000 | +100.0% | 0.24% | – |
| AYLA | New | AYALA PHARMACEUTICALS INC | $2,128,000 | – | 250,000 | +100.0% | 0.23% | – |
| BLSA | Sell | BCLS ACQUISITION CORP | $2,132,000 | -69.0% | 216,250 | -68.6% | 0.23% | -59.5% |
| QURE | UNIQURE NVcall | $2,074,000 | -35.2% | 100,000 | 0.0% | 0.23% | -15.2% | |
| CYCC | CYCLACEL PHARMACEUTICALS INC | $1,977,000 | -26.2% | 508,322 | 0.0% | 0.22% | -3.6% | |
| ARYA SCIENCES ACQUISITN CORP | $1,940,000 | -1.8% | 200,000 | 0.0% | 0.21% | +28.3% | ||
| KDNY | New | CHINOOK THERAPEUTICS INC | $1,821,000 | – | 111,653 | +100.0% | 0.20% | – |
| New | LIANBIOsponsored ads | $1,662,000 | – | 275,007 | +100.0% | 0.18% | – | |
| ARGX | Sell | ARGENX SEsponsored adr | $1,503,000 | -46.2% | 4,291 | -53.6% | 0.16% | -29.8% |
| ANNX | ANNEXON INC | $1,421,000 | -38.2% | 123,637 | 0.0% | 0.16% | -19.2% | |
| DYN | Sell | DYNE THERAPEUTICS INC | $1,251,000 | -65.8% | 105,204 | -53.3% | 0.14% | -55.0% |
| MGIC | MAGIC SOFTWARE ENTERPRISES Lord | $1,208,000 | +4.7% | 57,704 | 0.0% | 0.13% | +37.1% | |
| CYT | Sell | CYTEIR THERAPEUTICS INC | $1,124,000 | -52.6% | 98,860 | -26.8% | 0.12% | -37.7% |
| New | ARBE ROBOTICS LTDordinary shares | $1,120,000 | – | 120,400 | +100.0% | 0.12% | – | |
| VRTX | New | VERTEX PHARMACEUTICALS INC | $969,000 | – | 4,411 | +100.0% | 0.11% | – |
| NICE SYS INCnote 1.250% 1/1 | $921,000 | +8.9% | 250,000 | 0.0% | 0.10% | +42.3% | ||
| LVTX | Sell | LAVA THERAPEUTICS NV | $758,000 | -40.5% | 137,857 | -36.0% | 0.08% | -22.4% |
| IMTXW | IMMATICS N.V*w exp 07/01/202 | $439,000 | +3.8% | 100,000 | 0.0% | 0.05% | +33.3% | |
| OTLKW | OUTLOOK THERAPEUTICS INC*w exp 02/18/202 | $15,000 | -42.3% | 129,500 | 0.0% | 0.00% | 0.0% | |
| LOGC | Exit | LOGICBIO THERAPEUTICS INC | $0 | – | -24,042 | -100.0% | -0.01% | – |
| IMCR | Exit | IMMUNOCORE HLDGS PLCads | $0 | – | -4,235 | -100.0% | -0.01% | – |
| SRSA | Exit | SARISSA CAPITAL ACQUISITN COcl a | $0 | – | -23,900 | -100.0% | -0.02% | – |
| UPWK | Exit | UPWORK INC | $0 | – | -10,000 | -100.0% | -0.04% | – |
| IONS | Exit | IONIS PHARMACEUTICALS INC | $0 | – | -22,000 | -100.0% | -0.06% | – |
| CMLTU | Exit | CM LIFE SCIENCES III INCunit 04/30/2028 | $0 | – | -75,000 | -100.0% | -0.06% | – |
| YMTX | Exit | YUMANITY THERAPEUTICS INC | $0 | – | -75,836 | -100.0% | -0.07% | – |
| ACIU | Exit | AC IMMUNE SA | $0 | – | -121,019 | -100.0% | -0.07% | – |
| OMEG | Exit | OMEGA ALPHA SPACcl a | $0 | – | -100,000 | -100.0% | -0.08% | – |
| FLAC | Exit | FRAZIER LIFESCIENCES ACQU CO | $0 | – | -126,687 | -100.0% | -0.10% | – |
| Exit | ERASCA INC | $0 | – | -70,000 | -100.0% | -0.12% | – | |
| MOLN | Exit | MOLECULAR PARTNERS AGads | $0 | – | -80,555 | -100.0% | -0.13% | – |
| AMAT | Exit | APPLIED MATLS INC | $0 | – | -14,500 | -100.0% | -0.16% | – |
| ACHL | Exit | ACHILLES THERAPEUTICS PLCsponsored ads | $0 | – | -242,500 | -100.0% | -0.16% | – |
| JYAC | Exit | JIYA ACQUISITION CORP | $0 | – | -199,028 | -100.0% | -0.16% | – |
| TMPM | Exit | TURMERIC ACQUISITION CORPcl a | $0 | – | -219,440 | -100.0% | -0.18% | – |
| CVRX | Exit | CVRX INC | $0 | – | -150,000 | -100.0% | -0.21% | – |
| RPTX | Exit | REPARE THERAPEUTICS INC | $0 | – | -100,391 | -100.0% | -0.22% | – |
| Exit | HIPPO HLDGS INC | $0 | – | -564,967 | -100.0% | -0.22% | – | |
| GLUE | Exit | MONTE ROSA THERAPEUTICS INC | $0 | – | -119,647 | -100.0% | -0.22% | – |
| Exit | DICE THERAPEUTICS INC | $0 | – | -85,000 | -100.0% | -0.23% | – | |
| NTLA | Exit | INTELLIA THERAPEUTICS INC | $0 | – | -23,647 | -100.0% | -0.27% | – |
| EUCR | Exit | EUCRATES BIOMEDICAL ACQU COR | $0 | – | -329,025 | -100.0% | -0.27% | – |
| DVAX | Exit | DYNAVAX TECHNOLOGIES CORP | $0 | – | -198,880 | -100.0% | -0.32% | – |
| ALGS | Exit | ALIGOS THERAPEUTICS INC | $0 | – | -249,197 | -100.0% | -0.32% | – |
| IS | Exit | IRONSOURCE LTD | $0 | – | -367,070 | -100.0% | -0.34% | – |
| PTGX | Exit | PROTAGONIST THERAPEUTICS INC | $0 | – | -260,379 | -100.0% | -0.39% | – |
| FOLD | Exit | AMICUS THERAPEUTICS INC | $0 | – | -491,159 | -100.0% | -0.39% | – |
| Exit | CARIBOU BIOSCIENCES INC | $0 | – | -200,000 | -100.0% | -0.40% | – | |
| CALX | Exit | CALIX INC | $0 | – | -105,290 | -100.0% | -0.44% | – |
| QURE | Exit | UNIQURE NV | $0 | – | -172,000 | -100.0% | -0.46% | – |
| XENE | Exit | XENON PHARMACEUTICALS INC | $0 | – | -373,510 | -100.0% | -0.48% | – |
| RACB | Exit | RESEARCH ALLIANCE CORP II | $0 | – | -600,000 | -100.0% | -0.50% | – |
| ZEN | Exit | ZENDESK INC | $0 | – | -53,910 | -100.0% | -0.53% | – |
| AFMD | Exit | AFFIMED N V | $0 | – | -1,117,619 | -100.0% | -0.58% | – |
| ADSK | Exit | AUTODESK INC | $0 | – | -27,500 | -100.0% | -0.66% | – |
| RUN | Exit | SUNRUN INC | $0 | – | -189,000 | -100.0% | -0.70% | – |
| NKE | Exit | NIKE INCcl b | $0 | – | -65,000 | -100.0% | -0.79% | – |
| ALXO | Exit | ALX ONCOLOGY HLDGS INC | $0 | – | -128,706 | -100.0% | -0.80% | – |
| TEVA | Exit | TEVA PHARMACEUTICAL INDS LTDcall | $0 | – | -1,050,000 | -100.0% | -0.86% | – |
| AUDC | Exit | AUDIOCODES LTDord | $0 | – | -316,428 | -100.0% | -0.86% | – |
| KRNT | Exit | KORNIT DIGITAL LTD | $0 | – | -72,076 | -100.0% | -0.88% | – |
| NICE | Exit | NICE LTDsponsored adr | $0 | – | -37,786 | -100.0% | -0.90% | – |
| ALT | Exit | ALTIMMUNE INCcall | $0 | – | -1,000,000 | -100.0% | -0.95% | – |
| TWLO | Exit | TWILIO INCcl a | $0 | – | -35,500 | -100.0% | -0.95% | – |
| IONS | Exit | IONIS PHARMACEUTICALS INCcall | $0 | – | -350,000 | -100.0% | -0.99% | – |
| SEDG | Exit | SOLAREDGE TECHNOLOGIES INC | $0 | – | -50,000 | -100.0% | -1.11% | – |
| BIIB | Exit | BIOGEN INCcall | $0 | – | -50,000 | -100.0% | -1.19% | – |
| BMY | Exit | BRISTOL-MYERS SQUIBB COcall | $0 | – | -500,000 | -100.0% | -2.49% | – |
| IWM | Exit | ISHARES TRput | $0 | – | -210,000 | -100.0% | -3.86% | – |
| XBI | Exit | SPDR SER TRput | $0 | – | -400,000 | -100.0% | -4.22% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2022-02-14
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| TEVA PHARMACEUTICAL-SP ADR | 36 | Q3 2023 | 8.4% |
| MERCK & CO INC NEW | 35 | Q3 2023 | 8.4% |
| NICE Systems Ltd | 27 | Q3 2023 | 4.4% |
| BIOGEN INC | 26 | Q3 2023 | 6.7% |
| AMICUS THERAPEUTICS INC | 26 | Q2 2022 | 4.3% |
| PFIZER INC | 25 | Q3 2023 | 9.2% |
| SAREPTA THERAPEUTICS INC | 25 | Q3 2023 | 3.2% |
| JOHNSON & JOHNSON | 24 | Q3 2023 | 8.0% |
| UNIQURE NV | 23 | Q3 2023 | 1.2% |
| SYNDAX PHARMACEUTICALS INC | 22 | Q3 2023 | 3.9% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Cyclacel Pharmaceuticals, Inc. | February 06, 2023 | 250,000 | 2.0% |
| Altimmune, Inc. | February 14, 2022 | 1,244,241 | 3.1% |
| Allot Ltd. | February 16, 2021 | 1,129,054 | 3.2% |
| Larimar Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Neos Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Orgenesis Inc. | February 16, 2021 | 525,216 | 0.0% |
| Sio Gene Therapies Inc. | February 16, 2021 | ? | ? |
| X4 Pharmaceuticals, Inc | February 16, 2021 | 250,000 | 0.0% |
| Axovant Gene Therapies Ltd. | February 25, 2020 | 2,931,017 | 8.0% |
| Axovant Gene Therapies Ltd. | February 11, 2020 | 398,540 | 1.8% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 13F-HR/A | 2024-02-15 |
| 13F-HR | 2024-02-14 |
| SC 13G | 2024-02-08 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| 13F-HR | 2023-11-14 |
| SC 13G | 2023-10-10 |
| SC 13G | 2023-08-30 |
View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.