$1.06 Billion is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 87 reported holdings in Q2 2020. The portfolio turnover from Q1 2020 to Q2 2020 was 93.6% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| XBI | Buy | SPDR SER TRput | $83,962,000 | +116.8% | 750,000 | +50.0% | 7.90% | +63.0% |
| ABBV | Buy | ABBVIE INC | $72,123,000 | +473.7% | 734,598 | +345.2% | 6.78% | +331.5% |
| MRK | Sell | MERCK & CO. INC | $60,612,000 | -9.3% | 783,808 | -9.8% | 5.70% | -31.8% |
| SPY | Sell | SPDR S&P 500 ETF TRput | $58,280,000 | +7.7% | 189,000 | -10.0% | 5.48% | -19.0% |
| SNY | Buy | SANOFIsponsored adr | $57,176,000 | +34.8% | 1,120,000 | +15.5% | 5.38% | +1.4% |
| AZN | Buy | ASTRAZENECA PLCsponsored adr | $47,072,000 | +84.9% | 890,000 | +56.1% | 4.43% | +39.0% |
| JNJ | Sell | JOHNSON & JOHNSON | $42,189,000 | -7.7% | 300,000 | -14.0% | 3.97% | -30.6% |
| BMY | Sell | BRISTOL-MYERS SQUIBB CO | $41,160,000 | -5.3% | 700,000 | -10.3% | 3.87% | -28.8% |
| QQQ | New | INVESCO QQQ TRput | $38,997,000 | – | 157,500 | +100.0% | 3.67% | – |
| PFE | New | PFIZER INCput | $32,700,000 | – | 1,000,000 | +100.0% | 3.08% | – |
| NVO | Sell | NOVO-NORDISK A Sadr | $26,192,000 | -24.5% | 400,000 | -30.6% | 2.46% | -43.2% |
| FOLD | Sell | AMICUS THERAPEUTICS INC | $24,559,000 | +31.7% | 1,628,550 | -19.3% | 2.31% | -0.9% |
| NICE | New | NICE LTDsponsored adr | $24,489,000 | – | 129,406 | +100.0% | 2.30% | – |
| SRPT | Sell | SAREPTA THERAPEUTICS INC | $19,754,000 | -21.7% | 123,200 | -52.2% | 1.86% | -41.1% |
| AMGN | New | AMGEN INC | $18,869,000 | – | 80,000 | +100.0% | 1.78% | – |
| DCPH | Buy | DECIPHERA PHARMACEUTICALS IN | $16,899,000 | +243.5% | 282,965 | +136.8% | 1.59% | +158.4% |
| MSFT | Sell | MICROSOFT CORP | $16,680,000 | +12.6% | 81,964 | -12.8% | 1.57% | -15.3% |
| NVS | Buy | NOVARTIS AGsponsored adr | $15,721,000 | +36.2% | 180,000 | +28.6% | 1.48% | +2.4% |
| LLY | New | LILLY ELI & CO | $14,776,000 | – | 90,000 | +100.0% | 1.39% | – |
| RETA | New | REATA PHARMACEUTICALS INCcl a | $12,801,000 | – | 82,049 | +100.0% | 1.20% | – |
| FVRR | Buy | FIVERR INTL LTD | $12,328,000 | +367.1% | 167,002 | +59.3% | 1.16% | +251.2% |
| YMAB | Sell | Y-MABS THERAPEUTICS INC | $12,193,000 | +52.0% | 282,252 | -8.2% | 1.15% | +14.4% |
| AMZN | Sell | AMAZON COM INC | $11,918,000 | +16.0% | 4,320 | -18.0% | 1.12% | -12.8% |
| ALLT | Buy | ALLOT LTD | $10,087,000 | +16.6% | 963,456 | +5.3% | 0.95% | -12.3% |
| FIXX | New | HOMOLOGY MEDICINES INC | $10,009,000 | – | 658,919 | +100.0% | 0.94% | – |
| MYOK | New | MYOKARDIA INC | $9,662,000 | – | 100,000 | +100.0% | 0.91% | – |
| WIX | New | WIX COM LTD | $9,631,000 | – | 37,588 | +100.0% | 0.91% | – |
| IOVA | New | IOVANCE BIOTHERAPEUTICS INC | $9,553,000 | – | 348,000 | +100.0% | 0.90% | – |
| Sell | TRILLIUM THERAPEUTICS INC | $9,533,000 | +87.2% | 1,178,346 | -6.5% | 0.90% | +40.8% | |
| KRNT | New | KORNIT DIGITAL LTD | $9,422,000 | – | 176,507 | +100.0% | 0.89% | – |
| PASG | Sell | PASSAGE BIO INC | $9,414,000 | +31.9% | 344,439 | -28.0% | 0.88% | -0.8% |
| FISV | New | FISERV INC | $9,298,000 | – | 95,246 | +100.0% | 0.87% | – |
| KURA | New | KURA ONCOLOGY INC | $8,712,000 | – | 534,494 | +100.0% | 0.82% | – |
| MRTX | New | MIRATI THERAPEUTICS INC | $8,220,000 | – | 72,000 | +100.0% | 0.77% | – |
| AXGT | Sell | AXOVANT GENE THERAPIES | $8,060,000 | +12.7% | 2,857,998 | -2.5% | 0.76% | -15.3% |
| FATE | New | FATE THERAPEUTICS INC | $7,720,000 | – | 225,000 | +100.0% | 0.73% | – |
| RPTX | New | REPARE THERAPEUTICS INC | $7,600,000 | – | 245,000 | +100.0% | 0.72% | – |
| KPTI | Sell | KARYOPHARM THERAPEUTICS INC | $7,440,000 | -29.6% | 392,831 | -28.6% | 0.70% | -47.0% |
| TEVA | Buy | TEVA PHARMACEUTICAL INDS LTDsponsored ads | $7,187,000 | +124.4% | 582,878 | +63.4% | 0.68% | +68.6% |
| RCKT | Buy | ROCKET PHARMACEUTICALS INC | $7,117,000 | +52.3% | 340,016 | +1.5% | 0.67% | +14.6% |
| CNCE | Sell | CONCERT PHARMACEUTICALS INC | $6,972,000 | -22.1% | 700,710 | -30.8% | 0.66% | -41.4% |
| PANW | Buy | PALO ALTO NETWORKS INC | $6,890,000 | +155.5% | 30,000 | +82.3% | 0.65% | +92.3% |
| SEDG | New | SOLAREDGE TECHNOLOGIES INC | $6,386,000 | – | 46,017 | +100.0% | 0.60% | – |
| APRE | New | APREA THERAPEUTICS INC | $6,138,000 | – | 158,289 | +100.0% | 0.58% | – |
| KRYS | New | KRYSTAL BIOTECH INC | $5,988,000 | – | 144,573 | +100.0% | 0.56% | – |
| ITCI | New | INTRA CELLULAR THERAPIES INCcall | $5,871,000 | – | 228,700 | +100.0% | 0.55% | – |
| ADMA | Buy | ADMA BIOLOGICS INC | $5,816,000 | +9.9% | 1,984,949 | +8.0% | 0.55% | -17.4% |
| DOV | New | DOVER CORP | $5,560,000 | – | 57,576 | +100.0% | 0.52% | – |
| DPZ | New | DOMINOS PIZZA INC | $5,365,000 | – | 14,521 | +100.0% | 0.50% | – |
| XFOR | Sell | X4 PHARMACEUTICALS INC | $5,273,000 | -39.6% | 565,804 | -35.2% | 0.50% | -54.6% |
| RTRX | New | RETROPHIN INC | $5,103,000 | – | 250,000 | +100.0% | 0.48% | – |
| LRMR | New | LARIMAR THERAPEUTICS INC | $5,099,000 | – | 396,787 | +100.0% | 0.48% | – |
| ASND | Buy | ASCENDIS PHARMA A Ssponsored adr | $5,084,000 | +38.6% | 34,373 | +5.5% | 0.48% | +4.1% |
| QURE | Sell | UNIQURE NV | $4,957,000 | -48.1% | 110,000 | -45.3% | 0.47% | -61.0% |
| XCUR | Sell | EXICURE INC | $4,636,000 | -4.6% | 1,900,000 | -42.2% | 0.44% | -28.3% |
| ZYME | Sell | ZYMEWORKS INC | $4,195,000 | -42.8% | 116,310 | -43.8% | 0.40% | -57.0% |
| ORGS | Sell | ORGENESIS INC | $4,048,000 | -4.0% | 665,767 | -40.0% | 0.38% | -27.7% |
| ARYAU | ARYA SCIENCES ACQUISITION COunit 10/04/2023 | $4,000,000 | +77.1% | 200,000 | 0.0% | 0.38% | +33.3% | |
| ARYBU | New | ARYA SCIENCES ACQUISTION COunit 06/09/2027 | $3,480,000 | – | 300,000 | +100.0% | 0.33% | – |
| CPRX | New | CATALYST PHARMACEUTICALS INC | $3,375,000 | – | 730,557 | +100.0% | 0.32% | – |
| GRTX | Sell | GALERA THERAPEUTICS INC | $3,350,000 | -25.9% | 469,245 | -1.4% | 0.32% | -44.2% |
| ENPH | New | ENPHASE ENERGY INC | $3,330,000 | – | 70,000 | +100.0% | 0.31% | – |
| SNDX | Buy | SYNDAX PHARMACEUTICALS INC | $3,260,000 | +336.4% | 220,000 | +222.9% | 0.31% | +230.1% |
| WVE | New | WAVE LIFE SCIENCES LTD | $3,050,000 | – | 293,000 | +100.0% | 0.29% | – |
| CGEN | New | COMPUGEN LTDord | $3,004,000 | – | 200,000 | +100.0% | 0.28% | – |
| KALV | KALVISTA PHARMACEUTICALS INC | $2,906,000 | +58.2% | 240,140 | 0.0% | 0.27% | +18.7% | |
| PRGO | New | PERRIGO CO PLC | $2,764,000 | – | 50,000 | +100.0% | 0.26% | – |
| SLNO | New | SOLENO THERAPEUTICS INC | $2,739,000 | – | 1,233,676 | +100.0% | 0.26% | – |
| IMVT | Buy | IMMUNOVANT INC | $2,557,000 | +763.9% | 105,000 | +451.7% | 0.24% | +548.6% |
| ARGX | ARGENX SEsponsored adr | $2,312,000 | +71.0% | 10,265 | 0.0% | 0.22% | +28.4% | |
| AKUS | New | AKOUOS INC | $2,250,000 | – | 100,000 | +100.0% | 0.21% | – |
| AKBA | New | AKEBIA THERAPEUTICS INC | $2,105,000 | – | 155,000 | +100.0% | 0.20% | – |
| CRBP | New | CORBUS PHARMACEUTICALS HLDGScall | $2,001,000 | – | 238,500 | +100.0% | 0.19% | – |
| LPTX | Buy | LEAP THERAPEUTICS INC | $1,839,000 | +94.0% | 880,000 | +46.7% | 0.17% | +45.4% |
| MEIP | New | MEI PHARMA INC | $1,693,000 | – | 410,000 | +100.0% | 0.16% | – |
| VKTX | Sell | VIKING THERAPEUTICS INC | $1,478,000 | -46.5% | 205,000 | -65.3% | 0.14% | -59.7% |
| SNDX | New | SYNDAX PHARMACEUTICALS INCcall | $1,482,000 | – | 100,000 | +100.0% | 0.14% | – |
| NBSE | New | NEUBASE THERAPEUTICS INC | $1,317,000 | – | 150,000 | +100.0% | 0.12% | – |
| IMUX | New | IMMUNIC INC | $1,212,000 | – | 100,000 | +100.0% | 0.11% | – |
| ISEE | Buy | IVERIC BIO INC | $1,020,000 | +140.0% | 200,000 | +62.0% | 0.10% | +81.1% |
| BLU | New | BELLUS HEALTH INC NEW | $1,006,000 | – | 97,805 | +100.0% | 0.10% | – |
| NEOS | Sell | NEOS THERAPEUTICS INC | $651,000 | -65.4% | 950,311 | -62.1% | 0.06% | -74.0% |
| NICE SYS INCnote 1.250% 1/1 | $573,000 | +28.8% | 250,000 | 0.0% | 0.05% | -3.6% | ||
| CAMT | New | CAMTEK LTDord | $468,000 | – | 37,184 | +100.0% | 0.04% | – |
| TCRR | New | TCR2 THERAPEUTICS INC | $461,000 | – | 30,000 | +100.0% | 0.04% | – |
| CLRB | CELLECTAR BIOSCIENCES INC | $112,000 | +0.9% | 87,500 | 0.0% | 0.01% | -21.4% | |
| OTLKW | OUTLOOK THERAPEUTICS INC*w exp 02/18/202 | $33,000 | -74.6% | 129,500 | 0.0% | 0.00% | -81.2% | |
| MIST | Exit | MILESTONE PHARMACEUTICALS IN | $0 | – | -67,992 | -100.0% | -0.02% | – |
| BMYRT | Exit | BRISTOL-MYERS SQUIBB COright 99/99/9999 | $0 | – | -50,000 | -100.0% | -0.02% | – |
| SNSS | Exit | SUNESIS PHARMACEUTICALS INC | $0 | – | -721,800 | -100.0% | -0.04% | – |
| CYCN | Exit | CYCLERION THERAPEUTICS INC | $0 | – | -124,976 | -100.0% | -0.04% | – |
| ZYNE | Exit | ZYNERBA PHARMACEUTICALS INC | $0 | – | -100,000 | -100.0% | -0.05% | – |
| STOK | Exit | STOKE THERAPEUTICS INC | $0 | – | -27,254 | -100.0% | -0.08% | – |
| ALNA | Exit | ALLENA PHARMACEUTICALS INC | $0 | – | -667,800 | -100.0% | -0.08% | – |
| APTX | Exit | APTINYX INC | $0 | – | -411,666 | -100.0% | -0.11% | – |
| DTIL | Exit | PRECISION BIOSCIENCES INC | $0 | – | -147,352 | -100.0% | -0.11% | – |
| NERV | Exit | MINERVA NEUROSCIENCES INC | $0 | – | -168,357 | -100.0% | -0.13% | – |
| GBT | Exit | GLOBAL BLOOD THERAPEUTICS IN | $0 | – | -24,752 | -100.0% | -0.16% | – |
| IMVTU | Exit | IMMUNOVANT INCunit 12/18/2024 | $0 | – | -94,500 | -100.0% | -0.20% | – |
| VRTX | Exit | VERTEX PHARMACEUTICALS INC | $0 | – | -7,000 | -100.0% | -0.21% | – |
| PRQR | Exit | PROQR THRAPEUTICS N V | $0 | – | -346,148 | -100.0% | -0.24% | – |
| APLT | Exit | APPLIED THERAPEUTICS INC | $0 | – | -67,967 | -100.0% | -0.28% | – |
| EOLS | Exit | EVOLUS INC | $0 | – | -550,000 | -100.0% | -0.29% | – |
| ZFGN | Exit | ZAFGEN INC | $0 | – | -3,161,562 | -100.0% | -0.30% | – |
| SAVA | Exit | CASSAVA SCIENCES INC | $0 | – | -615,000 | -100.0% | -0.32% | – |
| ALDX | Exit | ALDEYRA THERAPEUTICS INC | $0 | – | -1,069,089 | -100.0% | -0.33% | – |
| PTI | Exit | PROTEOSTASIS THERAPEUTICS IN | $0 | – | -2,536,600 | -100.0% | -0.36% | – |
| PTGX | Exit | PROTAGONIST THERAPEUTICS INC | $0 | – | -526,075 | -100.0% | -0.46% | – |
| NLTX | Exit | NEOLEUKIN THERAPEUTICS INC | $0 | – | -397,000 | -100.0% | -0.56% | – |
| BEAM | Exit | BEAM THERAPEUTICS INC | $0 | – | -264,681 | -100.0% | -0.60% | – |
| AUDC | Exit | AUDIOCODES LTDord | $0 | – | -206,619 | -100.0% | -0.62% | – |
| CRM | Exit | SALESFORCE COM INC | $0 | – | -35,529 | -100.0% | -0.64% | – |
| ARVN | Exit | ARVINAS INC | $0 | – | -145,781 | -100.0% | -0.74% | – |
| BPMC | Exit | BLUEPRINT MEDICINES CORP | $0 | – | -109,500 | -100.0% | -0.80% | – |
| ACAD | Exit | ACADIA PHARMACEUTICALS INC | $0 | – | -157,000 | -100.0% | -0.83% | – |
| XLP | Exit | SELECT SECTOR SPDR TRsbi cons stpls | $0 | – | -145,207 | -100.0% | -0.99% | – |
| PFE | Exit | PFIZER INC | $0 | – | -550,000 | -100.0% | -2.24% | – |
| ALXN | Exit | ALEXION PHARMACEUTICALS INC | $0 | – | -249,396 | -100.0% | -2.80% | – |
| IWM | Exit | ISHARES TRput | $0 | – | -900,000 | -100.0% | -12.88% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2020-08-13
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| TEVA PHARMACEUTICAL-SP ADR | 36 | Q3 2023 | 8.4% |
| MERCK & CO INC NEW | 35 | Q3 2023 | 8.4% |
| NICE Systems Ltd | 27 | Q3 2023 | 4.4% |
| BIOGEN INC | 26 | Q3 2023 | 6.7% |
| AMICUS THERAPEUTICS INC | 26 | Q2 2022 | 4.3% |
| PFIZER INC | 25 | Q3 2023 | 9.2% |
| SAREPTA THERAPEUTICS INC | 25 | Q3 2023 | 3.2% |
| JOHNSON & JOHNSON | 24 | Q3 2023 | 8.0% |
| UNIQURE NV | 23 | Q3 2023 | 1.2% |
| SYNDAX PHARMACEUTICALS INC | 22 | Q3 2023 | 3.9% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Cyclacel Pharmaceuticals, Inc. | February 06, 2023 | 250,000 | 2.0% |
| Altimmune, Inc. | February 14, 2022 | 1,244,241 | 3.1% |
| Allot Ltd. | February 16, 2021 | 1,129,054 | 3.2% |
| Larimar Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Neos Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Orgenesis Inc. | February 16, 2021 | 525,216 | 0.0% |
| Sio Gene Therapies Inc. | February 16, 2021 | ? | ? |
| X4 Pharmaceuticals, Inc | February 16, 2021 | 250,000 | 0.0% |
| Axovant Gene Therapies Ltd. | February 25, 2020 | 2,931,017 | 8.0% |
| Axovant Gene Therapies Ltd. | February 11, 2020 | 398,540 | 1.8% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 13F-HR/A | 2024-02-15 |
| 13F-HR | 2024-02-14 |
| SC 13G | 2024-02-08 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| 13F-HR | 2023-11-14 |
| SC 13G | 2023-10-10 |
| SC 13G | 2023-08-30 |
View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.