$1.02 Billion is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 97 reported holdings in Q3 2020. The portfolio turnover from Q2 2020 to Q3 2020 was 79.3% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| MRK | Buy | MERCK & CO. INC | $73,312,000 | +21.0% | 883,808 | +12.8% | 7.20% | +26.4% |
| ABBV | Buy | ABBVIE INC | $69,196,000 | -4.1% | 790,000 | +7.5% | 6.80% | +0.2% |
| QQQ | Buy | INVESCO QQQ TRput | $58,346,000 | +49.6% | 210,000 | +33.3% | 5.73% | +56.3% |
| JNJ | Buy | JOHNSON & JOHNSON | $56,574,000 | +34.1% | 380,000 | +26.7% | 5.56% | +40.1% |
| SNY | SANOFIsponsored adr | $56,190,000 | -1.7% | 1,120,000 | 0.0% | 5.52% | +2.7% | |
| AZN | Sell | ASTRAZENECA PLCsponsored adr | $44,936,000 | -4.5% | 820,000 | -7.9% | 4.42% | -0.3% |
| LLY | New | LILLY ELI & COcall | $29,604,000 | – | 200,000 | +100.0% | 2.91% | – |
| AMGN | Buy | AMGEN INC | $27,958,000 | +48.2% | 110,000 | +37.5% | 2.75% | +54.8% |
| NVS | Buy | NOVARTIS AGsponsored adr | $24,784,000 | +57.6% | 285,000 | +58.3% | 2.44% | +64.7% |
| SRPT | Buy | SAREPTA THERAPEUTICS INC | $24,084,000 | +21.9% | 171,500 | +39.2% | 2.37% | +27.4% |
| LLY | Buy | LILLY ELI & CO | $23,091,000 | +56.3% | 156,000 | +73.3% | 2.27% | +63.2% |
| SRPT | New | SAREPTA THERAPEUTICS INCput | $21,064,000 | – | 150,000 | +100.0% | 2.07% | – |
| SRPT | New | SAREPTA THERAPEUTICS INCcall | $21,064,000 | – | 150,000 | +100.0% | 2.07% | – |
| DCPH | Buy | DECIPHERA PHARMACEUTICALS IN | $17,645,000 | +4.4% | 343,965 | +21.6% | 1.73% | +9.1% |
| FOLD | Sell | AMICUS THERAPEUTICS INC | $17,559,000 | -28.5% | 1,243,550 | -23.6% | 1.72% | -25.3% |
| YMAB | Buy | Y-MABS THERAPEUTICS INC | $15,222,000 | +24.8% | 396,521 | +40.5% | 1.50% | +30.4% |
| TEVA | Buy | TEVA PHARMACEUTICAL INDS LTDsponsored ads | $14,262,000 | +98.4% | 1,582,878 | +171.6% | 1.40% | +107.2% |
| NICE | Sell | NICE LTDsponsored adr | $14,185,000 | -42.1% | 62,481 | -51.7% | 1.39% | -39.5% |
| GNRC | New | GENERAC HLDGS INC | $12,974,000 | – | 67,000 | +100.0% | 1.28% | – |
| IWP | New | ISHARES TRput | $12,706,000 | – | 73,500 | +100.0% | 1.25% | – |
| AMZN | Sell | AMAZON COM INC | $12,028,000 | +0.9% | 3,820 | -11.6% | 1.18% | +5.4% |
| BTAI | New | BIOXCEL THERAPEUTICS INC | $11,677,000 | – | 269,300 | +100.0% | 1.15% | – |
| MYOK | Sell | MYOKARDIA INC | $11,043,000 | +14.3% | 81,000 | -19.0% | 1.08% | +19.4% |
| KURA | Sell | KURA ONCOLOGY INC | $11,015,000 | +26.4% | 359,494 | -32.7% | 1.08% | +32.1% |
| ABBV | New | ABBVIE INCcall | $10,949,000 | – | 125,000 | +100.0% | 1.08% | – |
| MSFT | Sell | MICROSOFT CORP | $10,785,000 | -35.3% | 51,278 | -37.4% | 1.06% | -32.4% |
| ALLT | Buy | ALLOT LTD | $9,513,000 | -5.7% | 1,045,337 | +8.5% | 0.94% | -1.5% |
| KRNT | Sell | KORNIT DIGITAL LTD | $9,301,000 | -1.3% | 143,381 | -18.8% | 0.91% | +3.2% |
| FB | New | FACEBOOK INCcl a | $9,167,000 | – | 35,000 | +100.0% | 0.90% | – |
| Sell | TRILLIUM THERAPEUTICS INC | $9,172,000 | -3.8% | 645,435 | -45.2% | 0.90% | +0.4% | |
| IMAB | New | I MABsponsored ads | $8,551,000 | – | 181,820 | +100.0% | 0.84% | – |
| IMTX | New | IMMATICS N.V | $8,488,000 | – | 800,000 | +100.0% | 0.83% | – |
| IOVA | Sell | IOVANCE BIOTHERAPEUTICS INC | $8,329,000 | -12.8% | 253,000 | -27.3% | 0.82% | -8.9% |
| FROG | New | JFROG LTD | $8,077,000 | – | 95,415 | +100.0% | 0.79% | – |
| FVRR | Sell | FIVERR INTL LTD | $7,964,000 | -35.4% | 57,301 | -65.7% | 0.78% | -32.4% |
| KRYS | Buy | KRYSTAL BIOTECH INC | $7,946,000 | +32.7% | 184,573 | +27.7% | 0.78% | +38.7% |
| WVE | Buy | WAVE LIFE SCIENCES LTD | $7,906,000 | +159.2% | 931,200 | +217.8% | 0.78% | +170.7% |
| RPTX | REPARE THERAPEUTICS INC | $7,539,000 | -0.8% | 245,000 | 0.0% | 0.74% | +3.6% | |
| SNDX | Buy | SYNDAX PHARMACEUTICALS INC | $7,528,000 | +130.9% | 510,000 | +131.8% | 0.74% | +141.0% |
| FATE | Sell | FATE THERAPEUTICS INC | $7,514,000 | -2.7% | 188,000 | -16.4% | 0.74% | +1.7% |
| FISV | Sell | FISERV INC | $7,239,000 | -22.1% | 70,246 | -26.2% | 0.71% | -18.6% |
| BURL | New | BURLINGTON STORES INC | $7,213,000 | – | 35,000 | +100.0% | 0.71% | – |
| VRNS | New | VARONIS SYS INC | $6,951,000 | – | 60,225 | +100.0% | 0.68% | – |
| DPZ | Buy | DOMINOS PIZZA INC | $6,898,000 | +28.6% | 16,221 | +11.7% | 0.68% | +34.3% |
| ALXO | New | ALX ONCOLOGY HLDGS INC | $6,871,000 | – | 182,070 | +100.0% | 0.68% | – |
| ZNTL | New | ZENTALIS PHARMACEUTICALS INC | $6,374,000 | – | 194,996 | +100.0% | 0.63% | – |
| VRNA | New | VERONA PHARMA PLCsponsored ads | $6,240,000 | – | 1,000,000 | +100.0% | 0.61% | – |
| ITOS | New | ITEOS THERAPEUTICS INC | $6,168,000 | – | 250,000 | +100.0% | 0.61% | – |
| IMVT | Buy | IMMUNOVANT INC | $5,982,000 | +133.9% | 170,000 | +61.9% | 0.59% | +145.0% |
| ALBO | New | ALBIREO PHARMA INC | $5,793,000 | – | 173,600 | +100.0% | 0.57% | – |
| RETA | Sell | REATA PHARMACEUTICALS INCcl a | $5,761,000 | -55.0% | 59,139 | -27.9% | 0.57% | -53.0% |
| ARNA | New | ARENA PHARMACEUTICALS INC | $5,609,000 | – | 75,000 | +100.0% | 0.55% | – |
| ARYBU | Buy | ARYA SCIENCES ACQUISTION COunit 06/09/2027 | $5,489,000 | +57.7% | 499,000 | +66.3% | 0.54% | +64.8% |
| CLDX | New | CELLDEX THERAPEUTICS INC NEW | $5,487,000 | – | 370,000 | +100.0% | 0.54% | – |
| MRTX | Sell | MIRATI THERAPEUTICS INC | $5,480,000 | -33.3% | 33,000 | -54.2% | 0.54% | -30.4% |
| AXGT | Sell | AXOVANT SCIENCES LTD | $5,327,000 | -33.9% | 1,152,998 | -59.7% | 0.52% | -31.0% |
| RCKT | Sell | ROCKET PHARMACEUTICALS INC | $5,212,000 | -26.8% | 228,016 | -32.9% | 0.51% | -23.5% |
| LRMR | Sell | LARIMAR THERAPEUTICS INC | $5,189,000 | +1.8% | 342,064 | -13.8% | 0.51% | +6.2% |
| KYMR | New | KYMERA THERAPEUTICS INC | $5,170,000 | – | 160,000 | +100.0% | 0.51% | – |
| INZY | New | INOZYME PHARMA INC | $5,164,000 | – | 196,411 | +100.0% | 0.51% | – |
| ASND | Sell | ASCENDIS PHARMA A/Ssponsored adr | $5,031,000 | -1.0% | 32,599 | -5.2% | 0.49% | +3.3% |
| QURE | Buy | UNIQURE NV | $4,641,000 | -6.4% | 126,000 | +14.5% | 0.46% | -2.1% |
| ARYA | New | ARYA SCIENCES ACQUISITION CO | $4,288,000 | – | 400,000 | +100.0% | 0.42% | – |
| GRTX | GALERA THERAPEUTICS INC | $4,242,000 | +26.6% | 469,245 | 0.0% | 0.42% | +32.4% | |
| AVRO | New | AVROBIO INC | $4,238,000 | – | 325,500 | +100.0% | 0.42% | – |
| KNSA | New | KINIKSA PHARMACEUTICALS LTD | $3,983,000 | – | 259,990 | +100.0% | 0.39% | – |
| ZYME | Sell | ZYMEWORKS INC | $3,726,000 | -11.2% | 80,000 | -31.2% | 0.37% | -7.3% |
| DRNA | New | DICERNA PHARMACEUTICALS INC | $3,598,000 | – | 199,980 | +100.0% | 0.35% | – |
| PASG | Sell | PASSAGE BIO INC | $3,488,000 | -62.9% | 266,037 | -22.8% | 0.34% | -61.2% |
| PRGO | Buy | PERRIGO CO PLC | $3,285,000 | +18.8% | 71,559 | +43.1% | 0.32% | +24.2% |
| ALT | New | ALTIMMUNE INC | $3,208,000 | – | 243,000 | +100.0% | 0.32% | – |
| ARVN | New | ARVINAS INC | $3,187,000 | – | 135,000 | +100.0% | 0.31% | – |
| CNCE | Sell | CONCERT PHARMACEUTICALS INC | $3,044,000 | -56.3% | 310,000 | -55.8% | 0.30% | -54.4% |
| KALV | KALVISTA PHARMACEUTICALS INC | $3,023,000 | +4.0% | 240,140 | 0.0% | 0.30% | +8.8% | |
| ARGX | ARGENX SEsponsored adr | $2,695,000 | +16.6% | 10,265 | 0.0% | 0.26% | +22.1% | |
| ADMA | Sell | ADMA BIOLOGICS INC | $2,584,000 | -55.6% | 1,081,292 | -45.5% | 0.25% | -53.6% |
| ATHA | New | ATHIRA PHARMA INC | $2,068,000 | – | 112,000 | +100.0% | 0.20% | – |
| ORGS | Sell | ORGENESIS INC | $2,010,000 | -50.3% | 398,803 | -40.1% | 0.20% | -48.0% |
| ALPN | New | ALPINE IMMUNE SCIENCES INC | $1,743,000 | – | 198,260 | +100.0% | 0.17% | – |
| EPIX | New | ESSA PHARMA INC | $1,725,000 | – | 250,000 | +100.0% | 0.17% | – |
| LPTX | Sell | LEAP THERAPEUTICS INC | $1,584,000 | -13.9% | 800,000 | -9.1% | 0.16% | -9.8% |
| ETNB | New | 89BIO INC | $1,512,000 | – | 58,939 | +100.0% | 0.15% | – |
| DYN | New | DYNE THERAPEUTICS INC | $1,413,000 | – | 70,000 | +100.0% | 0.14% | – |
| XCUR | Sell | EXICURE INC | $1,291,000 | -72.2% | 737,557 | -61.2% | 0.13% | -70.9% |
| NBSE | NEUBASE THERAPEUTICS INC | $1,139,000 | -13.5% | 150,000 | 0.0% | 0.11% | -9.7% | |
| HSAQ | New | HEALTH SCIENCES ACQ CORP 2 | $1,100,000 | – | 100,000 | +100.0% | 0.11% | – |
| PAND | New | PANDION THERAPEUTICS INC | $1,089,000 | – | 95,000 | +100.0% | 0.11% | – |
| SEDG | Sell | SOLAREDGE TECHNOLOGIES INC | $957,000 | -85.0% | 4,017 | -91.3% | 0.09% | -84.4% |
| NRIX | New | NURIX THERAPEUTICS INC | $785,000 | – | 22,480 | +100.0% | 0.08% | – |
| NICE SYS INCnote 1.250% 1/1 | $681,000 | +18.8% | 250,000 | 0.0% | 0.07% | +24.1% | ||
| CRDF | New | CARDIFF ONCOLOGY INC | $568,000 | – | 40,000 | +100.0% | 0.06% | – |
| IMTXW | New | IMMATICS N.V*w exp 07/01/202 | $350,000 | – | 100,000 | +100.0% | 0.03% | – |
| RACA | New | THERAPEUTICS ACQUISITION COR | $288,000 | – | 20,000 | +100.0% | 0.03% | – |
| CRBP | Sell | CORBUS PHARMACEUTICALS HLDGScall | $141,000 | -93.0% | 78,500 | -67.1% | 0.01% | -92.6% |
| CLRB | CELLECTAR BIOSCIENCES INC | $109,000 | -2.7% | 87,500 | 0.0% | 0.01% | 0.0% | |
| OTLKW | OUTLOOK THERAPEUTICS INC*w exp 02/18/202 | $17,000 | -48.5% | 129,500 | 0.0% | 0.00% | -33.3% | |
| TCRR | Exit | TCR2 THERAPEUTICS INC | $0 | – | -30,000 | -100.0% | -0.04% | – |
| CAMT | Exit | CAMTEK LTDord | $0 | – | -37,184 | -100.0% | -0.04% | – |
| NEOS | Exit | NEOS THERAPEUTICS INC | $0 | – | -950,311 | -100.0% | -0.06% | – |
| BLU | Exit | BELLUS HEALTH INC NEW | $0 | – | -97,805 | -100.0% | -0.10% | – |
| ISEE | Exit | IVERIC BIO INC | $0 | – | -200,000 | -100.0% | -0.10% | – |
| IMUX | Exit | IMMUNIC INC | $0 | – | -100,000 | -100.0% | -0.11% | – |
| SNDX | Exit | SYNDAX PHARMACEUTICALS INCcall | $0 | – | -100,000 | -100.0% | -0.14% | – |
| VKTX | Exit | VIKING THERAPEUTICS INC | $0 | – | -205,000 | -100.0% | -0.14% | – |
| MEIP | Exit | MEI PHARMA INC | $0 | – | -410,000 | -100.0% | -0.16% | – |
| AKBA | Exit | AKEBIA THERAPEUTICS INC | $0 | – | -155,000 | -100.0% | -0.20% | – |
| AKUS | Exit | AKOUOS INC | $0 | – | -100,000 | -100.0% | -0.21% | – |
| SLNO | Exit | SOLENO THERAPEUTICS INC | $0 | – | -1,233,676 | -100.0% | -0.26% | – |
| CGEN | Exit | COMPUGEN LTDord | $0 | – | -200,000 | -100.0% | -0.28% | – |
| ENPH | Exit | ENPHASE ENERGY INC | $0 | – | -70,000 | -100.0% | -0.31% | – |
| CPRX | Exit | CATALYST PHARMACEUTICALS INC | $0 | – | -730,557 | -100.0% | -0.32% | – |
| ARYAU | Exit | ARYA SCIENCES ACQUISITION COunit 10/04/2023 | $0 | – | -200,000 | -100.0% | -0.38% | – |
| RTRX | Exit | RETROPHIN INC | $0 | – | -250,000 | -100.0% | -0.48% | – |
| XFOR | Exit | X4 PHARMACEUTICALS INC | $0 | – | -565,804 | -100.0% | -0.50% | – |
| DOV | Exit | DOVER CORP | $0 | – | -57,576 | -100.0% | -0.52% | – |
| ITCI | Exit | INTRA CELLULAR THERAPIES INCcall | $0 | – | -228,700 | -100.0% | -0.55% | – |
| APRE | Exit | APREA THERAPEUTICS INC | $0 | – | -158,289 | -100.0% | -0.58% | – |
| PANW | Exit | PALO ALTO NETWORKS INC | $0 | – | -30,000 | -100.0% | -0.65% | – |
| KPTI | Exit | KARYOPHARM THERAPEUTICS INC | $0 | – | -392,831 | -100.0% | -0.70% | – |
| WIX | Exit | WIX COM LTD | $0 | – | -37,588 | -100.0% | -0.91% | – |
| FIXX | Exit | HOMOLOGY MEDICINES INC | $0 | – | -658,919 | -100.0% | -0.94% | – |
| NVO | Exit | NOVO-NORDISK A Sadr | $0 | – | -400,000 | -100.0% | -2.46% | – |
| PFE | Exit | PFIZER INCput | $0 | – | -1,000,000 | -100.0% | -3.08% | – |
| BMY | Exit | BRISTOL-MYERS SQUIBB CO | $0 | – | -700,000 | -100.0% | -3.87% | – |
| SPY | Exit | SPDR S&P 500 ETF TRput | $0 | – | -189,000 | -100.0% | -5.48% | – |
| XBI | Exit | SPDR SER TRput | $0 | – | -750,000 | -100.0% | -7.90% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2020-11-12
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| TEVA PHARMACEUTICAL-SP ADR | 36 | Q3 2023 | 8.4% |
| MERCK & CO INC NEW | 35 | Q3 2023 | 8.4% |
| NICE Systems Ltd | 27 | Q3 2023 | 4.4% |
| BIOGEN INC | 26 | Q3 2023 | 6.7% |
| AMICUS THERAPEUTICS INC | 26 | Q2 2022 | 4.3% |
| PFIZER INC | 25 | Q3 2023 | 9.2% |
| SAREPTA THERAPEUTICS INC | 25 | Q3 2023 | 3.2% |
| JOHNSON & JOHNSON | 24 | Q3 2023 | 8.0% |
| UNIQURE NV | 23 | Q3 2023 | 1.2% |
| SYNDAX PHARMACEUTICALS INC | 22 | Q3 2023 | 3.9% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Cyclacel Pharmaceuticals, Inc. | February 06, 2023 | 250,000 | 2.0% |
| Altimmune, Inc. | February 14, 2022 | 1,244,241 | 3.1% |
| Allot Ltd. | February 16, 2021 | 1,129,054 | 3.2% |
| Larimar Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Neos Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Orgenesis Inc. | February 16, 2021 | 525,216 | 0.0% |
| Sio Gene Therapies Inc. | February 16, 2021 | ? | ? |
| X4 Pharmaceuticals, Inc | February 16, 2021 | 250,000 | 0.0% |
| Axovant Gene Therapies Ltd. | February 25, 2020 | 2,931,017 | 8.0% |
| Axovant Gene Therapies Ltd. | February 11, 2020 | 398,540 | 1.8% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 13F-HR/A | 2024-02-15 |
| 13F-HR | 2024-02-14 |
| SC 13G | 2024-02-08 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| 13F-HR | 2023-11-14 |
| SC 13G | 2023-10-10 |
| SC 13G | 2023-08-30 |
View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.