$800 Million is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 78 reported holdings in Q1 2020. The portfolio turnover from Q4 2019 to Q1 2020 was 67.4% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| IWM | New | ISHARES TRput | $103,014,000 | – | 900,000 | +100.0% | 12.88% | – |
| MRK | Buy | MERCK & CO. INC | $66,824,000 | +32.4% | 868,518 | +56.5% | 8.36% | +100.9% |
| SPY | New | SPDR S&P 500 ETF TRput | $54,102,000 | – | 209,900 | +100.0% | 6.77% | – |
| JNJ | Sell | JOHNSON & JOHNSON | $45,719,000 | -28.5% | 348,653 | -20.5% | 5.72% | +8.4% |
| BMY | Sell | BRISTOL-MYERS SQUIBB CO | $43,477,000 | -26.0% | 780,000 | -14.8% | 5.44% | +12.4% |
| SNY | Sell | SANOFIsponsored adr | $42,408,000 | -25.9% | 970,000 | -14.9% | 5.30% | +12.5% |
| XBI | Sell | SPDR SER TRput | $38,720,000 | -85.5% | 500,000 | -82.1% | 4.84% | -77.9% |
| NVO | Sell | NOVO-NORDISK A Sadr | $34,675,000 | -6.4% | 576,000 | -10.0% | 4.34% | +42.1% |
| AZN | New | ASTRAZENECA PLCsponsored adr | $25,456,000 | – | 570,000 | +100.0% | 3.18% | – |
| SRPT | Buy | SAREPTA THERAPEUTICS INC | $25,238,000 | +39.7% | 258,000 | +84.3% | 3.16% | +112.0% |
| ALXN | Buy | ALEXION PHARMACEUTICALS INC | $22,393,000 | +78.9% | 249,396 | +115.5% | 2.80% | +171.7% |
| FOLD | Sell | AMICUS THERAPEUTICS INC | $18,643,000 | -31.6% | 2,017,624 | -28.0% | 2.33% | +3.7% |
| PFE | New | PFIZER INC | $17,952,000 | – | 550,000 | +100.0% | 2.24% | – |
| MSFT | Buy | MICROSOFT CORP | $14,819,000 | +60.0% | 93,964 | +60.0% | 1.85% | +142.9% |
| ABBV | New | ABBVIE INC | $12,571,000 | – | 165,000 | +100.0% | 1.57% | – |
| NVS | Sell | NOVARTIS A Gsponsored adr | $11,543,000 | -39.0% | 140,000 | -30.0% | 1.44% | -7.5% |
| KPTI | Buy | KARYOPHARM THERAPEUTICS INC | $10,566,000 | +67.0% | 550,000 | +66.7% | 1.32% | +153.6% |
| AMZN | Buy | AMAZON COM INC | $10,275,000 | +50.3% | 5,270 | +42.4% | 1.28% | +128.2% |
| QURE | Buy | UNIQURE NV | $9,543,000 | -4.6% | 201,107 | +44.1% | 1.19% | +44.9% |
| CNCE | Buy | CONCERT PHARMACEUTICALS INC | $8,955,000 | +593.1% | 1,013,039 | +623.6% | 1.12% | +956.6% |
| XFOR | Buy | X4 PHARMACEUTICALS INC | $8,732,000 | +13.3% | 873,215 | +21.3% | 1.09% | +72.0% |
| ALLT | Sell | ALLOT LTD | $8,650,000 | +4.8% | 915,302 | -5.7% | 1.08% | +59.1% |
| YMAB | Buy | Y-MABS THERAPEUTICS INC | $8,023,000 | +20.4% | 307,379 | +44.1% | 1.00% | +82.7% |
| XLP | New | SELECT SECTOR SPDR TRsbi cons stpls | $7,909,000 | – | 145,207 | +100.0% | 0.99% | – |
| ZYME | Buy | ZYMEWORKS INC | $7,336,000 | +2.8% | 206,830 | +31.7% | 0.92% | +56.1% |
| AXGT | Buy | AXOVANT GENE THERAPIES LTD | $7,152,000 | +250.4% | 2,931,018 | +635.4% | 0.90% | +432.7% |
| PASG | New | PASSAGE BIO INC | $7,135,000 | – | 478,171 | +100.0% | 0.89% | – |
| ACAD | Sell | ACADIA PHARMACEUTICALS INC | $6,633,000 | -56.6% | 157,000 | -56.0% | 0.83% | -34.1% |
| BPMC | Buy | BLUEPRINT MEDICINES CORP | $6,404,000 | -24.6% | 109,500 | +3.3% | 0.80% | +14.4% |
| ARVN | Sell | ARVINAS INC | $5,875,000 | -28.1% | 145,781 | -26.7% | 0.74% | +9.2% |
| ADMA | Buy | ADMA BIOLOGICS INC | $5,294,000 | +145.1% | 1,838,100 | +240.4% | 0.66% | +271.9% |
| CRM | New | SALESFORCE COM INC | $5,115,000 | – | 35,529 | +100.0% | 0.64% | – |
| New | TRILLIUM THERAPEUTICS INC | $5,093,000 | – | 1,260,694 | +100.0% | 0.64% | – | |
| AUDC | Sell | AUDIOCODES LTDord | $4,936,000 | -37.2% | 206,619 | -32.5% | 0.62% | -4.8% |
| DCPH | New | DECIPHERA PHARMACEUTICALS IN | $4,920,000 | – | 119,500 | +100.0% | 0.62% | – |
| XCUR | Buy | EXICURE INC | $4,861,000 | -41.2% | 3,284,795 | +13.7% | 0.61% | -10.7% |
| BEAM | New | BEAM THERAPEUTICS INC | $4,764,000 | – | 264,681 | +100.0% | 0.60% | – |
| RCKT | Sell | ROCKET PHARMACEUTICALS INC | $4,673,000 | -43.3% | 335,016 | -7.4% | 0.58% | -14.0% |
| NLTX | Buy | NEOLEUKIN THERAPEUTICS INC | $4,518,000 | -3.5% | 397,000 | +4.5% | 0.56% | +46.4% |
| GRTX | Buy | GALERA THERAPEUTICS INC | $4,519,000 | -27.2% | 475,677 | +0.9% | 0.56% | +10.6% |
| ORGS | New | ORGENESIS INC | $4,216,000 | – | 1,109,564 | +100.0% | 0.53% | – |
| PTGX | Sell | PROTAGONIST THERAPEUTICS INC | $3,714,000 | -16.4% | 526,075 | -16.5% | 0.46% | +27.0% |
| ASND | Sell | ASCENDIS PHARMA A Ssponsored adr | $3,668,000 | -64.3% | 32,573 | -55.8% | 0.46% | -45.7% |
| TEVA | Buy | TEVA PHARMACEUTICAL INDS LTDsponsored ads | $3,203,000 | +25.6% | 356,713 | +37.0% | 0.40% | +91.0% |
| PTI | PROTEOSTASIS THERAPEUTICS IN | $2,892,000 | -50.0% | 2,536,600 | 0.0% | 0.36% | -24.1% | |
| VKTX | VIKING THERAPEUTICS INC | $2,761,000 | -41.7% | 590,000 | 0.0% | 0.34% | -11.5% | |
| PANW | Sell | PALO ALTO NETWORKS INC | $2,697,000 | -62.3% | 16,452 | -46.9% | 0.34% | -42.9% |
| FVRR | Sell | FIVERR INTL LTD | $2,639,000 | -52.0% | 104,839 | -55.2% | 0.33% | -27.2% |
| ALDX | ALDEYRA THERAPEUTICS INC | $2,641,000 | -57.5% | 1,069,089 | 0.0% | 0.33% | -35.5% | |
| SAVA | New | CASSAVA SCIENCES INC | $2,528,000 | – | 615,000 | +100.0% | 0.32% | – |
| ZFGN | Buy | ZAFGEN INC | $2,434,000 | +530.6% | 3,161,562 | +809.4% | 0.30% | +850.0% |
| EOLS | Buy | EVOLUS INC | $2,283,000 | +25.0% | 550,000 | +266.7% | 0.29% | +90.7% |
| ARYAU | ARYA SCIENCES ACQUISITION COunit 10/04/2023 | $2,258,000 | -1.8% | 200,000 | 0.0% | 0.28% | +48.4% | |
| APLT | New | APPLIED THERAPEUTICS INC | $2,222,000 | – | 67,967 | +100.0% | 0.28% | – |
| PRQR | Sell | PROQR THRAPEUTICS N V | $1,900,000 | -76.2% | 346,148 | -57.0% | 0.24% | -63.8% |
| NEOS | Sell | NEOS THERAPEUTICS INC | $1,882,000 | -64.7% | 2,509,468 | -28.9% | 0.24% | -46.5% |
| KALV | Buy | KALVISTA PHARMACEUTICALS INC | $1,837,000 | -30.2% | 240,140 | +62.6% | 0.23% | +6.0% |
| VRTX | New | VERTEX PHARMACEUTICALS INC | $1,666,000 | – | 7,000 | +100.0% | 0.21% | – |
| IMVTU | Sell | IMMUNOVANT INCunit 12/18/2024 | $1,564,000 | -37.1% | 94,500 | -5.5% | 0.20% | -4.4% |
| ARGX | Sell | ARGENX SEsponsored adr | $1,352,000 | -49.2% | 10,265 | -38.1% | 0.17% | -22.8% |
| GBT | New | GLOBAL BLOOD THERAPEUTICS IN | $1,265,000 | – | 24,752 | +100.0% | 0.16% | – |
| NERV | Sell | MINERVA NEUROSCIENCES INC | $1,014,000 | -83.3% | 168,357 | -80.3% | 0.13% | -74.7% |
| LPTX | New | LEAP THERAPEUTICS INC | $948,000 | – | 600,000 | +100.0% | 0.12% | – |
| DTIL | Sell | PRECISION BIOSCIENCES INC | $889,000 | -87.0% | 147,352 | -70.2% | 0.11% | -80.4% |
| APTX | New | APTINYX INC | $889,000 | – | 411,666 | +100.0% | 0.11% | – |
| SNDX | New | SYNDAX PHARMACEUTICALS INC | $747,000 | – | 68,134 | +100.0% | 0.09% | – |
| ALNA | Sell | ALLENA PHARMACEUTICALS INC | $643,000 | -74.3% | 667,800 | -27.2% | 0.08% | -61.4% |
| STOK | Sell | STOKE THERAPEUTICS INC | $624,000 | -91.4% | 27,254 | -89.4% | 0.08% | -87.0% |
| New | NICE SYS INCnote 1.250% 1/1 | $445,000 | – | 250,000 | +100.0% | 0.06% | – | |
| ISEE | Sell | IVERIC BIO INC | $425,000 | -94.3% | 123,424 | -85.8% | 0.05% | -91.4% |
| ZYNE | New | ZYNERBA PHARMACEUTICALS INC | $383,000 | – | 100,000 | +100.0% | 0.05% | – |
| CYCN | New | CYCLERION THERAPEUTICS INC | $331,000 | – | 124,976 | +100.0% | 0.04% | – |
| SNSS | Sell | SUNESIS PHARMACEUTICALS INC | $299,000 | -58.6% | 721,800 | -66.3% | 0.04% | -38.3% |
| IMVT | Sell | IMMUNOVANT INC | $296,000 | -6.6% | 19,032 | -4.8% | 0.04% | +42.3% |
| BMYRT | New | BRISTOL-MYERS SQUIBB COright 99/99/9999 | $190,000 | – | 50,000 | +100.0% | 0.02% | – |
| MIST | New | MILESTONE PHARMACEUTICALS IN | $125,000 | – | 67,992 | +100.0% | 0.02% | – |
| OTLKW | New | OUTLOOK THERAPEUTICS INC*w exp 02/18/202 | $130,000 | – | 129,500 | +100.0% | 0.02% | – |
| CLRB | CELLECTAR BIOSCIENCES INC | $111,000 | -43.7% | 87,500 | 0.0% | 0.01% | -12.5% | |
| BLCM | Exit | BELLICUM PHARMACEUTICALS INC | $0 | – | -400,000 | -100.0% | -0.04% | – |
| MLNX | Exit | MELLANOX TECHNOLOGIES LTD | $0 | – | -8,452 | -100.0% | -0.08% | – |
| IFRX | Exit | INFLARX NV | $0 | – | -330,000 | -100.0% | -0.11% | – |
| ASMB | Exit | ASSEMBLY BIOSCIENCES INC | $0 | – | -88,248 | -100.0% | -0.15% | – |
| ABEO | Exit | ABEONA THERAPEUTICS INC | $0 | – | -720,472 | -100.0% | -0.19% | – |
| CYTK | Exit | CYTOKINETICS INC | $0 | – | -268,747 | -100.0% | -0.24% | – |
| WAB | Exit | WABTEC CORP | $0 | – | -40,000 | -100.0% | -0.26% | – |
| NVMI | Exit | NOVA MEASURING INSTRUMENTS L | $0 | – | -91,466 | -100.0% | -0.28% | – |
| KRNT | Exit | KORNIT DIGITAL LTD | $0 | – | -101,759 | -100.0% | -0.29% | – |
| BURL | Exit | BURLINGTON STORES INC | $0 | – | -19,500 | -100.0% | -0.37% | – |
| FSCT | Exit | FORESCOUT TECHNOLOGIES INC | $0 | – | -137,021 | -100.0% | -0.37% | – |
| RTRX | Exit | RETROPHIN INC | $0 | – | -317,381 | -100.0% | -0.37% | – |
| PRNB | Exit | PRINCIPIA BIOPHARMA INC | $0 | – | -86,500 | -100.0% | -0.39% | – |
| KRYS | Exit | KRYSTAL BIOTECH INC | $0 | – | -86,280 | -100.0% | -0.39% | – |
| RARE | Exit | ULTRAGENYX PHARMACEUTICAL IN | $0 | – | -115,000 | -100.0% | -0.40% | – |
| WIX | Exit | WIX COM LTD | $0 | – | -41,415 | -100.0% | -0.42% | – |
| CSTE | Exit | CAESARSTONE LTD | $0 | – | -354,357 | -100.0% | -0.44% | – |
| SEDG | Exit | SOLAREDGE TECHNOLOGIES INC | $0 | – | -56,822 | -100.0% | -0.44% | – |
| BLUE | Exit | BLUEBIRD BIO INC | $0 | – | -64,500 | -100.0% | -0.47% | – |
| HARP | Exit | HARPOON THERAPEUTICS INC | $0 | – | -384,031 | -100.0% | -0.47% | – |
| ARQL | Exit | ARQULE INC | $0 | – | -297,227 | -100.0% | -0.49% | – |
| PTLA | Exit | PORTOLA PHARMACEUTICALS INC | $0 | – | -317,000 | -100.0% | -0.62% | – |
| SWTX | Exit | SPRINGWORKS THERAPEUTICS INC | $0 | – | -200,000 | -100.0% | -0.63% | – |
| FISV | Exit | FISERV INC | $0 | – | -67,279 | -100.0% | -0.64% | – |
| GWPH | Exit | GW PHARMACEUTICALS PLCads | $0 | – | -77,000 | -100.0% | -0.66% | – |
| PTCT | Exit | PTC THERAPEUTICS INC | $0 | – | -214,736 | -100.0% | -0.85% | – |
| MYL | Exit | MYLAN N V | $0 | – | -560,000 | -100.0% | -0.93% | – |
| TEVA | Exit | TEVA PHARMACEUTICAL INDS LTDcall | $0 | – | -1,220,600 | -100.0% | -0.99% | – |
| VRNT | Exit | VERINT SYS INC | $0 | – | -290,699 | -100.0% | -1.33% | – |
| BMRN | Exit | BIOMARIN PHARMACEUTICAL INC | $0 | – | -251,382 | -100.0% | -1.75% | – |
| SGEN | Exit | SEATTLE GENETICS INCcall | $0 | – | -250,000 | -100.0% | -2.35% | – |
| GILD | Exit | GILEAD SCIENCES INCcall | $0 | – | -500,000 | -100.0% | -2.68% | – |
| IBB | Exit | ISHARES TRput | $0 | – | -1,000,000 | -100.0% | -9.93% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2020-05-14
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| TEVA PHARMACEUTICAL-SP ADR | 36 | Q3 2023 | 8.4% |
| MERCK & CO INC NEW | 35 | Q3 2023 | 8.4% |
| NICE Systems Ltd | 27 | Q3 2023 | 4.4% |
| BIOGEN INC | 26 | Q3 2023 | 6.7% |
| AMICUS THERAPEUTICS INC | 26 | Q2 2022 | 4.3% |
| PFIZER INC | 25 | Q3 2023 | 9.2% |
| SAREPTA THERAPEUTICS INC | 25 | Q3 2023 | 3.2% |
| JOHNSON & JOHNSON | 24 | Q3 2023 | 8.0% |
| UNIQURE NV | 23 | Q3 2023 | 1.2% |
| SYNDAX PHARMACEUTICALS INC | 22 | Q3 2023 | 3.9% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Cyclacel Pharmaceuticals, Inc. | February 06, 2023 | 250,000 | 2.0% |
| Altimmune, Inc. | February 14, 2022 | 1,244,241 | 3.1% |
| Allot Ltd. | February 16, 2021 | 1,129,054 | 3.2% |
| Larimar Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Neos Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Orgenesis Inc. | February 16, 2021 | 525,216 | 0.0% |
| Sio Gene Therapies Inc. | February 16, 2021 | ? | ? |
| X4 Pharmaceuticals, Inc | February 16, 2021 | 250,000 | 0.0% |
| Axovant Gene Therapies Ltd. | February 25, 2020 | 2,931,017 | 8.0% |
| Axovant Gene Therapies Ltd. | February 11, 2020 | 398,540 | 1.8% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 13F-HR/A | 2024-02-15 |
| 13F-HR | 2024-02-14 |
| SC 13G | 2024-02-08 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| 13F-HR | 2023-11-14 |
| SC 13G | 2023-10-10 |
| SC 13G | 2023-08-30 |
View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.