$1.21 Billion is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 86 reported holdings in Q4 2019. The portfolio turnover from Q3 2019 to Q4 2019 was 59.5% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| XBI | New | SPDR SERIES TRUSTput | $266,308,000 | – | 2,800,000 | +100.0% | 21.95% | – |
| IBB | New | ISHARES TRput | $120,510,000 | – | 1,000,000 | +100.0% | 9.93% | – |
| JNJ | Buy | JOHNSON & JOHNSON | $63,986,000 | +23.6% | 438,653 | +9.7% | 5.27% | -34.0% |
| BMY | Sell | BRISTOL MYERS SQUIBB CO | $58,734,000 | +4.4% | 915,000 | -17.6% | 4.84% | -44.3% |
| SNY | Buy | SANOFIsponsored adr | $57,228,000 | +76.5% | 1,140,000 | +62.9% | 4.72% | -5.9% |
| MRK | Buy | MERCK & CO INC | $50,477,000 | +27.6% | 555,000 | +18.1% | 4.16% | -31.9% |
| NVO | Buy | NOVO-NORDISK A Sadr | $37,043,000 | +59.2% | 640,000 | +42.2% | 3.05% | -15.1% |
| GILD | New | GILEAD SCIENCES INCcall | $32,490,000 | – | 500,000 | +100.0% | 2.68% | – |
| SGEN | New | SEATTLE GENETICS INCcall | $28,565,000 | – | 250,000 | +100.0% | 2.35% | – |
| FOLD | Sell | AMICUS THERAPEUTICS INC | $27,275,000 | +16.1% | 2,800,320 | -4.4% | 2.25% | -38.1% |
| BMRN | New | BIOMARIN PHARMACEUTICAL INC | $21,254,000 | – | 251,382 | +100.0% | 1.75% | – |
| NVS | New | NOVARTIS A Gsponsored adr | $18,938,000 | – | 200,000 | +100.0% | 1.56% | – |
| SRPT | Sell | SAREPTA THERAPEUTICS INC | $18,066,000 | -3.3% | 140,000 | -43.6% | 1.49% | -48.4% |
| VRNT | Buy | VERINT SYS INC | $16,093,000 | +179.7% | 290,699 | +116.2% | 1.33% | +49.2% |
| ACAD | Buy | ACADIA PHARMACEUTICALS INC | $15,272,000 | +371.5% | 357,000 | +296.7% | 1.26% | +151.8% |
| ALXN | Sell | ALEXION PHARMACEUTICALS INC | $12,514,000 | -22.9% | 115,713 | -30.2% | 1.03% | -58.9% |
| TEVA | New | TEVA PHARMACEUTICAL INDS LTDcall | $11,962,000 | – | 1,220,600 | +100.0% | 0.99% | – |
| MYL | New | MYLAN N V | $11,256,000 | – | 560,000 | +100.0% | 0.93% | – |
| PTCT | Sell | PTC THERAPEUTICS INC | $10,314,000 | -1.6% | 214,736 | -30.7% | 0.85% | -47.5% |
| ASND | ASCENDIS PHARMA A Ssponsored adr | $10,263,000 | +44.4% | 73,773 | 0.0% | 0.85% | -23.0% | |
| QURE | Sell | UNIQURE NV | $9,998,000 | +43.1% | 139,514 | -21.4% | 0.82% | -23.6% |
| MSFT | Buy | MICROSOFT CORP | $9,263,000 | +24.0% | 58,741 | +9.3% | 0.76% | -33.9% |
| BPMC | Buy | BLUEPRINT MEDICINES CORP | $8,492,000 | +172.0% | 106,000 | +149.4% | 0.70% | +45.2% |
| XCUR | Buy | EXICURE INC | $8,262,000 | +23.8% | 2,888,888 | +9.5% | 0.68% | -33.9% |
| ALLT | Buy | ALLOT LTD | $8,251,000 | +54.9% | 970,666 | +46.8% | 0.68% | -17.4% |
| RCKT | Sell | ROCKET PHARMACEUTICALS INC | $8,237,000 | +7.1% | 361,888 | -45.2% | 0.68% | -42.8% |
| ARVN | Sell | ARVINAS INC | $8,168,000 | +84.6% | 198,781 | -3.2% | 0.67% | -1.5% |
| GWPH | Buy | GW PHARMACEUTICALS PLCads | $8,051,000 | -5.4% | 77,000 | +4.1% | 0.66% | -49.6% |
| PRQR | Sell | PROQR THRAPEUTICS N V | $7,978,000 | +51.4% | 805,000 | -12.0% | 0.66% | -19.3% |
| AUDC | Sell | AUDIOCODES LTDord | $7,863,000 | +26.7% | 306,053 | -6.8% | 0.65% | -32.4% |
| FISV | FISERV INC | $7,779,000 | +11.6% | 67,279 | 0.0% | 0.64% | -40.5% | |
| XFOR | Buy | X4 PHARMACEUTICALS INC | $7,704,000 | +1179.7% | 720,000 | +1419.3% | 0.64% | +582.8% |
| SWTX | Sell | SPRINGWORKS THERAPEUTICS INC | $7,698,000 | +14.5% | 200,000 | -35.5% | 0.63% | -38.9% |
| PTLA | Buy | PORTOLA PHARMACEUTICALS INC | $7,570,000 | +8.6% | 317,000 | +21.9% | 0.62% | -42.1% |
| ISEE | New | IVERIC BIO INC | $7,449,000 | – | 868,200 | +100.0% | 0.61% | – |
| STOK | Sell | STOKE THERAPEUTICS INC | $7,261,000 | -1.7% | 256,380 | -26.0% | 0.60% | -47.6% |
| PANW | Sell | PALO ALTO NETWORKS INC | $7,163,000 | +6.6% | 30,976 | -6.1% | 0.59% | -43.2% |
| ZYME | Sell | ZYMEWORKS INC | $7,137,000 | +69.3% | 157,000 | -7.6% | 0.59% | -9.7% |
| DTIL | Buy | PRECISION BIOSCIENCES INC | $6,858,000 | +124.0% | 493,739 | +35.3% | 0.56% | +19.5% |
| AMZN | Buy | AMAZON COM INC | $6,837,000 | +79.0% | 3,700 | +68.2% | 0.56% | -4.6% |
| YMAB | Buy | Y MABS THERAPEUTICS INC | $6,665,000 | +34.6% | 213,293 | +12.3% | 0.55% | -28.2% |
| KPTI | New | KARYOPHARM THERAPEUTICS INC | $6,326,000 | – | 330,000 | +100.0% | 0.52% | – |
| ALDX | ALDEYRA THERAPEUTICS INC | $6,211,000 | +10.2% | 1,069,089 | 0.0% | 0.51% | -41.1% | |
| GRTX | New | GALERA THERAPEUTICS INC | $6,204,000 | – | 471,439 | +100.0% | 0.51% | – |
| NERV | Buy | MINERVA NEUROSCIENCES INC | $6,079,000 | +2.9% | 855,000 | +12.2% | 0.50% | -45.1% |
| ARQL | Sell | ARQULE INC | $5,933,000 | -60.3% | 297,227 | -85.7% | 0.49% | -78.8% |
| PTI | New | PROTEOSTASIS THERAPEUTICS IN | $5,783,000 | – | 2,536,600 | +100.0% | 0.48% | – |
| HARP | Buy | HARPOON THERAPEUTICS INC | $5,680,000 | +11.2% | 384,031 | +2.7% | 0.47% | -40.7% |
| BLUE | New | BLUEBIRD BIO INC | $5,660,000 | – | 64,500 | +100.0% | 0.47% | – |
| FVRR | Buy | FIVERR INTL LTD | $5,494,000 | +107.9% | 233,805 | +65.4% | 0.45% | +11.0% |
| SEDG | Sell | SOLAREDGE TECHNOLOGIES INC | $5,403,000 | +0.8% | 56,822 | -11.2% | 0.44% | -46.3% |
| CSTE | Sell | CAESARSTONE LTD | $5,340,000 | -30.3% | 354,357 | -23.2% | 0.44% | -62.8% |
| NEOS | Sell | NEOS THERAPEUTICS INC | $5,331,000 | -7.8% | 3,530,731 | -9.7% | 0.44% | -50.9% |
| WIX | Buy | WIX COM LTD | $5,068,000 | +17.7% | 41,415 | +12.3% | 0.42% | -37.1% |
| RARE | New | ULTRAGENYX PHARMACEUTICAL IN | $4,912,000 | – | 115,000 | +100.0% | 0.40% | – |
| KRYS | Sell | KRYSTAL BIOTECH INC | $4,778,000 | +17.0% | 86,280 | -26.6% | 0.39% | -37.6% |
| VKTX | New | VIKING THERAPEUTICS INC | $4,732,000 | – | 590,000 | +100.0% | 0.39% | – |
| PRNB | New | PRINCIPIA BIOPHARMA INC | $4,738,000 | – | 86,500 | +100.0% | 0.39% | – |
| NLTX | New | NEOLEUKIN THERAPEUTICS INC | $4,682,000 | – | 379,998 | +100.0% | 0.39% | – |
| RTRX | Sell | RETROPHIN INC | $4,507,000 | +17.8% | 317,381 | -3.9% | 0.37% | -37.2% |
| FSCT | Sell | FORESCOUT TECHNOLOGIES INC | $4,494,000 | -31.8% | 137,021 | -21.1% | 0.37% | -63.7% |
| BURL | BURLINGTON STORES INC | $4,447,000 | +14.1% | 19,500 | 0.0% | 0.37% | -39.2% | |
| PTGX | New | PROTAGONIST THERAPEUTICS INC | $4,442,000 | – | 630,000 | +100.0% | 0.37% | – |
| KRNT | Sell | KORNIT DIGITAL LTD | $3,483,000 | -14.0% | 101,759 | -22.7% | 0.29% | -54.2% |
| NVMI | Buy | NOVA MEASURING INSTRUMENTS L | $3,460,000 | +109.7% | 91,466 | +76.1% | 0.28% | +11.8% |
| WAB | WABTEC CORP | $3,112,000 | +8.3% | 40,000 | 0.0% | 0.26% | -42.3% | |
| CYTK | New | CYTOKINETICS INC | $2,851,000 | – | 268,747 | +100.0% | 0.24% | – |
| ARGX | Sell | ARGENX SEsponsored adr | $2,662,000 | -39.5% | 16,581 | -57.0% | 0.22% | -67.7% |
| KALV | New | KALVISTA PHARMACEUTICALS INC | $2,631,000 | – | 147,700 | +100.0% | 0.22% | – |
| TEVA | Sell | TEVA PHARMACEUTICAL INDS LTDsponsored ads | $2,551,000 | -76.1% | 260,352 | -83.2% | 0.21% | -87.2% |
| ALNA | Buy | ALLENA PHARMACEUTICALS INC | $2,506,000 | -5.6% | 917,800 | +36.2% | 0.21% | -49.5% |
| IMVTU | New | IMMUNOVANT INCunit 12/18/2024 | $2,487,000 | – | 100,000 | +100.0% | 0.20% | – |
| ABEO | New | ABEONA THERAPEUTICS INC | $2,356,000 | – | 720,472 | +100.0% | 0.19% | – |
| ARYAU | ARYA SCIENCES ACQUISITION COunit 10/04/2023 | $2,300,000 | +5.1% | 200,000 | 0.0% | 0.19% | -43.8% | |
| ADMA | New | ADMA BIOLOGICS INC | $2,160,000 | – | 540,000 | +100.0% | 0.18% | – |
| AXGT | Sell | AXOVANT GENE THERAPIES LTD | $2,041,000 | -52.7% | 398,541 | -40.4% | 0.17% | -74.8% |
| EOLS | New | EVOLUS INC | $1,826,000 | – | 150,000 | +100.0% | 0.15% | – |
| ASMB | Sell | ASSEMBLY BIOSCIENCES INC | $1,806,000 | +53.1% | 88,248 | -26.5% | 0.15% | -18.1% |
| IFRX | New | INFLARX NV | $1,307,000 | – | 330,000 | +100.0% | 0.11% | – |
| CNCE | CONCERT PHARMACEUTICALS INC | $1,292,000 | +57.0% | 140,000 | 0.0% | 0.11% | -16.5% | |
| MLNX | Sell | MELLANOX TECHNOLOGIES LTD | $990,000 | -88.2% | 8,452 | -89.0% | 0.08% | -93.7% |
| SNSS | SUNESIS PHARMACEUTICALS INC | $723,000 | -53.1% | 2,141,800 | 0.0% | 0.06% | -74.8% | |
| BLCM | Sell | BELLICUM PHARMACEUTICALS INC | $516,000 | -34.5% | 400,000 | -46.7% | 0.04% | -64.8% |
| ZFGN | New | ZAFGEN INC | $386,000 | – | 347,670 | +100.0% | 0.03% | – |
| IMVT | New | IMMUNOVANT INC | $317,000 | – | 20,000 | +100.0% | 0.03% | – |
| CLRB | CELLECTAR BIOSCIENCES INC | $197,000 | +12.6% | 87,500 | 0.0% | 0.02% | -40.7% | |
| TUFN | Exit | TUFIN SOFTWARE TECHNOLOGIS L | $0 | – | -12,231 | -100.0% | -0.03% | – |
| MRSN | Exit | MERSANA THERAPEUTICS INC | $0 | – | -200,000 | -100.0% | -0.05% | – |
| CUE | Exit | CUE BIOPHARMA INC | $0 | – | -50,000 | -100.0% | -0.06% | – |
| ERYP | Exit | ERYTECH PHARMAsponsored adr | $0 | – | -117,837 | -100.0% | -0.08% | – |
| ABUS | Exit | ARBUTUS BIOPHARMA CORP | $0 | – | -500,000 | -100.0% | -0.12% | – |
| HSACU | Exit | HEALTH SCIENCES ACQUSTN CORPunit 04/01/2024 | $0 | – | -100,000 | -100.0% | -0.17% | – |
| PRVL | Exit | PREVAIL THERAPEUTICS INC | $0 | – | -90,217 | -100.0% | -0.17% | – |
| AVRO | Exit | AVROBIO INC | $0 | – | -126,324 | -100.0% | -0.28% | – |
| DK | Exit | DELEK US HLDGS INC NEW | $0 | – | -50,000 | -100.0% | -0.28% | – |
| CHTR | Exit | CHARTER COMMUNICATIONS INC Ncl a | $0 | – | -6,000 | -100.0% | -0.38% | – |
| AKRO | Exit | AKERO THERAPEUTICS INC | $0 | – | -130,000 | -100.0% | -0.46% | – |
| ITRN | Exit | ITURAN LOCATION AND CONTROL | $0 | – | -135,311 | -100.0% | -0.52% | – |
| STRO | Exit | SUTRO BIOPHARMA INC | $0 | – | -422,589 | -100.0% | -0.59% | – |
| CHMA | Exit | CHIASMA INC | $0 | – | -990,000 | -100.0% | -0.76% | – |
| RETA | Exit | REATA PHARMACEUTICALS INCcl a | $0 | – | -63,269 | -100.0% | -0.78% | – |
| URGN | Exit | UROGEN PHARMA LTD | $0 | – | -335,817 | -100.0% | -1.24% | – |
| DRNA | Exit | DICERNA PHARMACEUTICALS INC | $0 | – | -565,000 | -100.0% | -1.25% | – |
| NICE | Exit | NICE LTDsponsored adr | $0 | – | -57,193 | -100.0% | -1.27% | – |
| CELG | Exit | CELGENE CORP | $0 | – | -250,000 | -100.0% | -3.84% | – |
| GILD | Exit | GILEAD SCIENCES INC | $0 | – | -705,000 | -100.0% | -6.90% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2020-02-13
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| TEVA PHARMACEUTICAL-SP ADR | 36 | Q3 2023 | 8.4% |
| MERCK & CO INC NEW | 35 | Q3 2023 | 8.4% |
| NICE Systems Ltd | 27 | Q3 2023 | 4.4% |
| BIOGEN INC | 26 | Q3 2023 | 6.7% |
| AMICUS THERAPEUTICS INC | 26 | Q2 2022 | 4.3% |
| PFIZER INC | 25 | Q3 2023 | 9.2% |
| SAREPTA THERAPEUTICS INC | 25 | Q3 2023 | 3.2% |
| JOHNSON & JOHNSON | 24 | Q3 2023 | 8.0% |
| UNIQURE NV | 23 | Q3 2023 | 1.2% |
| SYNDAX PHARMACEUTICALS INC | 22 | Q3 2023 | 3.9% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Cyclacel Pharmaceuticals, Inc. | February 06, 2023 | 250,000 | 2.0% |
| Altimmune, Inc. | February 14, 2022 | 1,244,241 | 3.1% |
| Allot Ltd. | February 16, 2021 | 1,129,054 | 3.2% |
| Larimar Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Neos Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Orgenesis Inc. | February 16, 2021 | 525,216 | 0.0% |
| Sio Gene Therapies Inc. | February 16, 2021 | ? | ? |
| X4 Pharmaceuticals, Inc | February 16, 2021 | 250,000 | 0.0% |
| Axovant Gene Therapies Ltd. | February 25, 2020 | 2,931,017 | 8.0% |
| Axovant Gene Therapies Ltd. | February 11, 2020 | 398,540 | 1.8% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 13F-HR/A | 2024-02-15 |
| 13F-HR | 2024-02-14 |
| SC 13G | 2024-02-08 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| 13F-HR | 2023-11-14 |
| SC 13G | 2023-10-10 |
| SC 13G | 2023-08-30 |
View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.