$887 Million is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 100 reported holdings in Q4 2018. The portfolio turnover from Q3 2018 to Q4 2018 was 54.0% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| XBI | Buy | SPDR SERIES TRUSTput | $193,725,000 | +83.7% | 2,700,000 | +145.5% | 21.84% | +80.4% |
| MYL | Buy | MYLAN N V | $45,956,000 | -5.2% | 1,677,241 | +26.6% | 5.18% | -7.0% |
| MRK | Sell | MERCK & CO INC | $36,066,000 | -34.8% | 472,000 | -39.5% | 4.06% | -36.0% |
| BMY | Buy | BRISTOL MYERS SQUIBB CO | $32,747,000 | -2.3% | 630,000 | +16.7% | 3.69% | -4.1% |
| CELG | New | CELGENE CORP | $29,802,000 | – | 465,000 | +100.0% | 3.36% | – |
| CSTE | Sell | CAESARSTONE LTD | $23,808,000 | +128.7% | 469,160 | -16.4% | 2.68% | +124.5% |
| VRNT | Sell | VERINT SYS INC | $23,573,000 | +213.4% | 149,100 | -0.7% | 2.66% | +207.9% |
| FOLD | Buy | AMICUS THERAPEUTICS INC | $23,452,000 | +8.5% | 2,447,994 | +36.9% | 2.64% | +6.5% |
| GILD | Sell | GILEAD SCIENCES INC | $21,893,000 | -32.5% | 350,000 | -16.7% | 2.47% | -33.7% |
| AZN | New | ASTRAZENECA PLCsponsored adr | $19,560,000 | – | 515,000 | +100.0% | 2.20% | – |
| MSFT | Sell | MICROSOFT CORP | $17,838,000 | +123.9% | 46,998 | -32.5% | 2.01% | +119.8% |
| PANW | New | PALO ALTO NETWORKS INC | $17,514,000 | – | 24,885 | +100.0% | 1.97% | – |
| ALXN | Buy | ALEXION PHARMACEUTICALS INC | $16,366,000 | -16.9% | 168,100 | +18.6% | 1.84% | -18.4% |
| ITRN | New | ITURAN LOCATION AND CONTROL | $14,637,000 | – | 122,177 | +100.0% | 1.65% | – |
| BLUE | Buy | BLUEBIRD BIO INC | $13,769,000 | +20.3% | 138,796 | +77.0% | 1.55% | +18.1% |
| ALLT | Buy | ALLOT COMMUNICATIONS LTD | $13,513,000 | +481.0% | 595,764 | +58.3% | 1.52% | +470.4% |
| SRPT | Buy | SAREPTA THERAPEUTICS INC | $12,716,000 | +3.4% | 116,517 | +53.1% | 1.43% | +1.6% |
| RETA | Buy | REATA PHARMACEUTICALS INCcl a | $12,413,000 | +63.7% | 221,269 | +138.6% | 1.40% | +60.8% |
| PTCT | Buy | PTC THERAPEUTICS INC | $11,858,000 | +20.1% | 345,500 | +64.5% | 1.34% | +18.0% |
| GSK | Sell | GLAXOSMITHKLINE PLCsponsored adr | $11,845,000 | -65.9% | 310,000 | -64.2% | 1.34% | -66.5% |
| TEVA | Buy | TEVA PHARMACEUTICAL INDS LTDsponsored adr | $10,863,000 | +152.2% | 704,500 | +252.2% | 1.22% | +147.3% |
| ALDX | Buy | ALDEYRA THERAPEUTICS INC | $10,226,000 | -35.1% | 1,232,089 | +7.9% | 1.15% | -36.3% |
| IMMU | Buy | IMMUNOMEDICS INC | $10,082,000 | -30.8% | 706,539 | +1.1% | 1.14% | -32.1% |
| SAGE | Buy | SAGE THERAPEUTICS INC | $9,914,000 | +17.0% | 103,500 | +72.5% | 1.12% | +14.8% |
| MLNX | Sell | MELLANOX TECHNOLOGIES LTD | $9,787,000 | +166.0% | 28,351 | -43.4% | 1.10% | +161.4% |
| ARGX | Sell | ARGENX SEsponsored adr | $8,366,000 | -19.1% | 87,081 | -36.1% | 0.94% | -20.6% |
| AXGT | New | AXOVANT SCIENCES LTD | $8,167,000 | – | 8,200,000 | +100.0% | 0.92% | – |
| GWPH | New | GW PHARMACEUTICALS PLCads | $7,499,000 | – | 77,000 | +100.0% | 0.84% | – |
| CLLS | CELLECTIS S Asponsored ads | $7,459,000 | -41.0% | 447,970 | 0.0% | 0.84% | -42.0% | |
| RTRX | RETROPHIN INC | $7,370,000 | -21.2% | 325,678 | 0.0% | 0.83% | -22.6% | |
| OSMT | New | OSMOTICA PHARMACEUTICALS PLC | $7,147,000 | – | 922,200 | +100.0% | 0.81% | – |
| QURE | Buy | UNIQURE NV | $6,711,000 | +3.7% | 232,849 | +30.9% | 0.76% | +1.7% |
| AUTL | Sell | AUTOLUS THERAPEUTICS PLCspon ads | $6,666,000 | -25.4% | 202,994 | -31.5% | 0.75% | -26.8% |
| GBT | New | GLOBAL BLOOD THERAPEUTICS IN | $6,034,000 | – | 147,000 | +100.0% | 0.68% | – |
| ORTX | New | ORCHARD THERAPEUTICS PLCads | $5,820,000 | – | 370,000 | +100.0% | 0.66% | – |
| FSCT | Sell | FORESCOUT TECHNOLOGIES INC | $5,746,000 | +22.3% | 59,169 | -52.5% | 0.65% | +20.0% |
| VKTX | Sell | VIKING THERAPEUTICS INC | $5,705,000 | -61.9% | 745,727 | -13.3% | 0.64% | -62.6% |
| GILT | Buy | GILAT SATELLITE NETWORKS LTD | $5,705,000 | +308.1% | 166,663 | +2.0% | 0.64% | +301.9% |
| ARQL | Buy | ARQULE INC | $5,630,000 | -50.4% | 2,032,643 | +1.4% | 0.64% | -51.3% |
| PRQR | Sell | PROQR THRAPEUTICS N V | $5,365,000 | -30.5% | 340,000 | -14.7% | 0.60% | -31.7% |
| NERV | Sell | MINERVA NEUROSCIENCES INC | $5,271,000 | -50.1% | 782,018 | -7.2% | 0.59% | -51.1% |
| BHVN | Sell | BIOHAVEN PHARMACTL HLDG CO L | $4,919,000 | -15.8% | 133,015 | -14.5% | 0.55% | -17.3% |
| MHK | New | MOHAWK INDS INC | $4,659,000 | – | 10,661 | +100.0% | 0.52% | – |
| EPZM | Buy | EPIZYME INC | $4,617,000 | +9.0% | 749,502 | +87.6% | 0.52% | +7.0% |
| AGLE | Sell | AEGLEA BIOTHERAPEUTICS INC | $4,494,000 | -28.1% | 600,000 | -8.1% | 0.51% | -29.4% |
| LOGC | New | LOGICBIO THERAPEUTICS INC | $4,343,000 | – | 417,625 | +100.0% | 0.49% | – |
| RCKT | New | ROCKET PHARMACEUTICALS INC | $4,298,000 | – | 290,001 | +100.0% | 0.48% | – |
| SBBP | Sell | STRONGBRIDGE BIOPHARMA PLC | $4,174,000 | -27.0% | 931,600 | -21.0% | 0.47% | -28.4% |
| CTMX | Buy | CYTOMX THERAPEUTICS INC | $4,125,000 | -4.4% | 273,151 | +17.2% | 0.46% | -6.1% |
| SRRK | Sell | SCHOLAR ROCK HLDG CORP | $4,031,000 | -47.3% | 175,511 | -40.9% | 0.45% | -48.3% |
| CARA | Buy | CARA THERAPEUTICS INC | $3,951,000 | -35.5% | 303,930 | +18.8% | 0.44% | -36.8% |
| SGMO | New | SANGAMO THERAPEUTICS INC | $3,903,000 | – | 340,000 | +100.0% | 0.44% | – |
| STRO | Buy | SUTRO BIOPHARMA INC | $3,679,000 | -10.8% | 407,889 | +48.3% | 0.42% | -12.4% |
| ASND | Sell | ASCENDIS PHARMA A Ssponsored adr | $3,651,000 | -44.4% | 58,273 | -37.1% | 0.41% | -45.4% |
| NEOS | Buy | NEOS THERAPEUTICS INC | $3,633,000 | -9.9% | 2,201,697 | +164.7% | 0.41% | -11.7% |
| KRYS | New | KRYSTAL BIOTECH INC | $3,629,000 | – | 174,625 | +100.0% | 0.41% | – |
| FIXX | Sell | HOMOLOGY MEDICINES INC | $3,600,000 | -35.7% | 161,000 | -34.3% | 0.41% | -36.9% |
| EVOK | EVOKE PHARMA INC | $3,499,000 | -16.8% | 1,410,946 | 0.0% | 0.39% | -18.4% | |
| ARVN | Buy | ARVINAS INC | $3,483,000 | -14.0% | 271,053 | +12.9% | 0.39% | -15.5% |
| XBI | New | SPDR SERIES TRUSTs&p biotech | $3,228,000 | – | 45,000 | +100.0% | 0.36% | – |
| AGIO | New | AGIOS PHARMACEUTICALS INC | $3,112,000 | – | 67,500 | +100.0% | 0.35% | – |
| KDMN | KADMON HLDGS INC | $3,099,000 | -37.7% | 1,490,000 | 0.0% | 0.35% | -38.9% | |
| ALLO | New | ALLOGENE THERAPEUTICS INC | $3,055,000 | – | 113,437 | +100.0% | 0.34% | – |
| ACIU | Sell | AC IMMUNE SA | $2,935,000 | -27.2% | 310,613 | -38.3% | 0.33% | -28.5% |
| PTLA | PORTOLA PHARMACEUTICALS INC | $2,869,000 | -26.7% | 147,000 | 0.0% | 0.32% | -28.1% | |
| XENE | Buy | XENON PHARMACEUTICALS INC | $2,836,000 | -43.4% | 449,484 | +18.4% | 0.32% | -44.3% |
| DCPH | Buy | DECIPHERA PHARMACEUTICALS IN | $2,415,000 | -43.3% | 115,033 | +4.5% | 0.27% | -44.4% |
| GLYC | GLYCOMIMETICS INC | $2,377,000 | -34.2% | 251,013 | 0.0% | 0.27% | -35.4% | |
| SAGE | New | SAGE THERAPEUTICS INCput | $2,347,000 | – | 24,500 | +100.0% | 0.26% | – |
| TBIO | Buy | TRANSLATE BIO INC | $2,321,000 | -16.1% | 309,400 | +11.8% | 0.26% | -17.6% |
| VTGN | Sell | VISTAGEN THERAPEUTICS INC | $2,211,000 | -8.9% | 1,473,918 | -11.9% | 0.25% | -10.8% |
| KRNT | New | KORNIT DIGITAL LTD | $2,122,000 | – | 30,342 | +100.0% | 0.24% | – |
| ARYA | New | ARYA SCIENCES ACQUISITION CO | $2,048,000 | – | 200,000 | +100.0% | 0.23% | – |
| ARPO | AERPIO PHARMACEUTICALS INC | $1,924,000 | -45.0% | 1,131,819 | 0.0% | 0.22% | -45.9% | |
| ABEO | Sell | ABEONA THERAPEUTICS INC | $1,928,000 | -55.3% | 270,036 | -19.9% | 0.22% | -56.2% |
| ALNA | Buy | ALLENA PHARMACEUTICALS INC | $1,881,000 | -40.7% | 345,199 | +16.9% | 0.21% | -41.8% |
| ZFGN | Sell | ZAFGEN INC | $1,881,000 | -62.6% | 380,000 | -11.6% | 0.21% | -63.3% |
| PIRS | Sell | PIERIS PHARMACEUTICALS INC | $1,862,000 | -63.2% | 700,000 | -22.6% | 0.21% | -63.9% |
| ARRY | Sell | ARRAY BIOPHARMA INC | $1,781,000 | -70.3% | 125,000 | -68.4% | 0.20% | -70.8% |
| MTEM | MOLECULAR TEMPLATES INC | $1,616,000 | -25.0% | 400,000 | 0.0% | 0.18% | -26.6% | |
| APLS | Sell | APELLIS PHARMACEUTICALS INC | $1,543,000 | -59.2% | 117,000 | -44.9% | 0.17% | -59.9% |
| UROV | Buy | UROVANT SCIENCES LTD | $1,410,000 | -28.4% | 214,030 | +30.5% | 0.16% | -29.6% |
| DOVA | Buy | DOVA PHARMACEUTICALS INC | $1,402,000 | -44.3% | 185,000 | +54.2% | 0.16% | -45.3% |
| NICE SYS INCnote 1.250% 1/1 | $1,286,000 | +258.2% | 250,000 | 0.0% | 0.14% | +253.7% | ||
| MLNT | MELINTA THERAPEUTICS INC | $1,282,000 | -79.9% | 1,616,867 | 0.0% | 0.14% | -80.4% | |
| CLSD | Buy | CLEARSIDE BIOMEDICAL INC | $1,268,000 | -82.1% | 1,185,124 | +2.6% | 0.14% | -82.5% |
| IDRA | New | IDERA PHARMACEUTICALS INC | $1,234,000 | – | 445,558 | +100.0% | 0.14% | – |
| CRVS | CORVUS PHARMACEUTICALS INC | $1,180,000 | -57.2% | 321,430 | 0.0% | 0.13% | -58.0% | |
| SVRA | Sell | SAVARA INC | $833,000 | -64.4% | 110,000 | -47.5% | 0.09% | -65.1% |
| ERYP | ERYTECH PHARMAsponsored adr | $796,000 | -23.9% | 120,000 | 0.0% | 0.09% | -25.0% | |
| VRCA | Sell | VERRICA PHARMACEUTICALS INC | $791,000 | -58.4% | 97,000 | -17.1% | 0.09% | -59.2% |
| MGTX | New | MEIRAGTX HOLDINGS PLC | $686,000 | – | 71,159 | +100.0% | 0.08% | – |
| SBPH | New | SPRING BK PHARMACEUTICALS IN | $530,000 | – | 51,015 | +100.0% | 0.06% | – |
| KZR | Sell | KEZAR LIFE SCIENCES INC | $472,000 | -89.6% | 20,000 | -90.6% | 0.05% | -89.8% |
| SRRA | Sell | SIERRA ONCOLOGY INC | $341,000 | -80.4% | 258,510 | -74.7% | 0.04% | -81.0% |
| CNST | New | CONSTELLATION PHARMCETICLS I | $281,000 | – | 70,162 | +100.0% | 0.03% | – |
| CUE | Buy | CUE BIOPHARMA INC | $235,000 | +29.8% | 50,000 | +150.0% | 0.03% | +23.8% |
| ADVM | Sell | ADVERUM BIOTECHNOLOGIES INC | $200,000 | -55.9% | 63,355 | -15.5% | 0.02% | -55.8% |
| BNTC | BENITEC BIOPHARMA LTDspons adr new | $180,000 | -38.8% | 120,000 | 0.0% | 0.02% | -41.2% | |
| CLRB | CELLECTAR BIOSCIENCES INC | $136,000 | -48.3% | 87,500 | 0.0% | 0.02% | -50.0% | |
| CMCSA | Exit | COMCAST CORP NEWcl a | $0 | – | -5,993 | -100.0% | -0.02% | – |
| SITE | Exit | SITEONE LANDSCAPE SUPPLY INC | $0 | – | -3,000 | -100.0% | -0.03% | – |
| CISN | Exit | CISION LTD | $0 | – | -15,000 | -100.0% | -0.03% | – |
| ULTI | Exit | ULTIMATE SOFTWARE GROUP INC | $0 | – | -800 | -100.0% | -0.03% | – |
| LOW | Exit | LOWES COS INC | $0 | – | -2,500 | -100.0% | -0.03% | – |
| EIDX | Exit | EIDOS THERAPEUTICS INC | $0 | – | -31,522 | -100.0% | -0.04% | – |
| ABUS | Exit | ARBUTUS BIOPHARMA CORP | $0 | – | -40,000 | -100.0% | -0.04% | – |
| SERV | Exit | SERVICEMASTER GLOBAL HLDGS I | $0 | – | -9,500 | -100.0% | -0.04% | – |
| VKTX | Exit | VIKING THERAPEUTICS INCcall | $0 | – | -23,900 | -100.0% | -0.05% | – |
| CHTR | Exit | CHARTER COMMUNICATIONS INC Ncl a | $0 | – | -1,419 | -100.0% | -0.05% | – |
| RDWR | Exit | RADWARE LTDord | $0 | – | -17,527 | -100.0% | -0.05% | – |
| UNH | Exit | UNITEDHEALTH GROUP INC | $0 | – | -2,000 | -100.0% | -0.06% | – |
| AUDC | Exit | AUDIOCODES LTDord | $0 | – | -59,226 | -100.0% | -0.07% | – |
| Exit | TEVA PHARMACEUTICAL FIN LLCdbcv 0.250% 2/0 | $0 | – | -2,135 | -100.0% | -0.10% | – | |
| AAP | Exit | ADVANCE AUTO PARTS INC | $0 | – | -5,336 | -100.0% | -0.10% | – |
| ZYME | Exit | ZYMEWORKS INC | $0 | – | -73,800 | -100.0% | -0.13% | – |
| SESN | Exit | SESEN BIO INC | $0 | – | -630,000 | -100.0% | -0.16% | – |
| AQST | Exit | AQUESTIVE THERAPEUTICS INC | $0 | – | -95,300 | -100.0% | -0.19% | – |
| FLEX | Exit | FLEX LTDord | $0 | – | -159,549 | -100.0% | -0.24% | – |
| LPTX | Exit | LEAP THERAPEUTICS INC | $0 | – | -332,525 | -100.0% | -0.30% | – |
| ALNY | Exit | ALNYLAM PHARMACEUTICALS INC | $0 | – | -40,000 | -100.0% | -0.40% | – |
| ASMB | Exit | ASSEMBLY BIOSCIENCES INC | $0 | – | -100,431 | -100.0% | -0.43% | – |
| ORLY | Exit | O REILLY AUTOMOTIVE INC NEW | $0 | – | -10,844 | -100.0% | -0.43% | – |
| GOOGL | Exit | ALPHABET INCcap stk cl a | $0 | – | -3,269 | -100.0% | -0.45% | – |
| IDRA | Exit | IDERA PHARMACEUTICALS INC | $0 | – | -445,558 | -100.0% | -0.46% | – |
| SNA | Exit | SNAP ON INC | $0 | – | -21,666 | -100.0% | -0.46% | – |
| OBSV | Exit | OBSEVA SA | $0 | – | -243,669 | -100.0% | -0.50% | – |
| BOLD | Exit | AUDENTES THERAPEUTICS INC | $0 | – | -120,000 | -100.0% | -0.54% | – |
| CSCO | Exit | CISCO SYS INC | $0 | – | -100,000 | -100.0% | -0.56% | – |
| MA | Exit | MASTERCARD INCORPORATEDcl a | $0 | – | -22,760 | -100.0% | -0.58% | – |
| IFF | Exit | INTERNATIONAL FLAVORS&FRAGRA | $0 | – | -36,450 | -100.0% | -0.58% | – |
| MRTX | Exit | MIRATI THERAPEUTICS INC | $0 | – | -112,908 | -100.0% | -0.61% | – |
| WAB | Exit | WABTEC CORP | $0 | – | -53,114 | -100.0% | -0.64% | – |
| SEDG | Exit | SOLAREDGE TECHNOLOGIES INC | $0 | – | -150,817 | -100.0% | -0.65% | – |
| V | Exit | VISA INC | $0 | – | -40,401 | -100.0% | -0.70% | – |
| BMRN | Exit | BIOMARIN PHARMACEUTICAL INC | $0 | – | -88,000 | -100.0% | -0.98% | – |
| JNJ | Exit | JOHNSON & JOHNSON | $0 | – | -325,000 | -100.0% | -5.16% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2019-02-14
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| TEVA PHARMACEUTICAL-SP ADR | 36 | Q3 2023 | 8.4% |
| MERCK & CO INC NEW | 35 | Q3 2023 | 8.4% |
| NICE Systems Ltd | 27 | Q3 2023 | 4.4% |
| BIOGEN INC | 26 | Q3 2023 | 6.7% |
| AMICUS THERAPEUTICS INC | 26 | Q2 2022 | 4.3% |
| PFIZER INC | 25 | Q3 2023 | 9.2% |
| SAREPTA THERAPEUTICS INC | 25 | Q3 2023 | 3.2% |
| JOHNSON & JOHNSON | 24 | Q3 2023 | 8.0% |
| UNIQURE NV | 23 | Q3 2023 | 1.2% |
| SYNDAX PHARMACEUTICALS INC | 22 | Q3 2023 | 3.9% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Cyclacel Pharmaceuticals, Inc. | February 06, 2023 | 250,000 | 2.0% |
| Altimmune, Inc. | February 14, 2022 | 1,244,241 | 3.1% |
| Allot Ltd. | February 16, 2021 | 1,129,054 | 3.2% |
| Larimar Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Neos Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Orgenesis Inc. | February 16, 2021 | 525,216 | 0.0% |
| Sio Gene Therapies Inc. | February 16, 2021 | ? | ? |
| X4 Pharmaceuticals, Inc | February 16, 2021 | 250,000 | 0.0% |
| Axovant Gene Therapies Ltd. | February 25, 2020 | 2,931,017 | 8.0% |
| Axovant Gene Therapies Ltd. | February 11, 2020 | 398,540 | 1.8% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 13F-HR/A | 2024-02-15 |
| 13F-HR | 2024-02-14 |
| SC 13G | 2024-02-08 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| 13F-HR | 2023-11-14 |
| SC 13G | 2023-10-10 |
| SC 13G | 2023-08-30 |
View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.