$871 Million is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 113 reported holdings in Q3 2018. The portfolio turnover from Q2 2018 to Q3 2018 was 55.0% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| XBI | New | SPDR SERIES TRUSTput | $105,457,000 | – | 1,100,000 | +100.0% | 12.11% | – |
| MRK | Buy | MERCK & CO INC | $55,333,000 | +34.1% | 780,000 | +14.7% | 6.35% | +11.6% |
| MYL | Buy | MYLAN N V | $48,495,000 | +57.1% | 1,325,000 | +55.2% | 5.57% | +30.8% |
| JNJ | New | JOHNSON & JOHNSON | $44,905,000 | – | 325,000 | +100.0% | 5.16% | – |
| GSK | Buy | GLAXOSMITHKLINE PLCsponsored adr | $34,747,000 | +12.7% | 865,000 | +13.1% | 3.99% | -6.2% |
| BMY | New | BRISTOL MYERS SQUIBB CO | $33,523,000 | – | 540,000 | +100.0% | 3.85% | – |
| GILD | Buy | GILEAD SCIENCES INC | $32,428,000 | +28.9% | 420,000 | +18.3% | 3.72% | +7.4% |
| FOLD | Buy | AMICUS THERAPEUTICS INC | $21,617,000 | +16.4% | 1,787,994 | +50.4% | 2.48% | -3.1% |
| ALXN | Sell | ALEXION PHARMACEUTICALS INC | $19,698,000 | -1.2% | 141,700 | -11.7% | 2.26% | -17.7% |
| ALDX | Buy | ALDEYRA THERAPEUTICS INC | $15,761,000 | +134.1% | 1,142,089 | +34.8% | 1.81% | +94.9% |
| VKTX | Buy | VIKING THERAPEUTICS INC | $14,976,000 | +101.7% | 859,727 | +9.9% | 1.72% | +67.9% |
| IMMU | Buy | IMMUNOMEDICS INC | $14,561,000 | +100.6% | 699,039 | +128.0% | 1.67% | +67.0% |
| CLLS | Buy | CELLECTIS S Asponsored ads | $12,642,000 | +27.0% | 447,970 | +27.3% | 1.45% | +5.8% |
| SRPT | Sell | SAREPTA THERAPEUTICS INC | $12,293,000 | -35.9% | 76,116 | -47.5% | 1.41% | -46.6% |
| BLUE | Buy | BLUEBIRD BIO INC | $11,446,000 | +0.6% | 78,396 | +8.2% | 1.31% | -16.2% |
| ARQL | Buy | ARQULE INC | $11,350,000 | +37.0% | 2,005,243 | +33.9% | 1.30% | +14.1% |
| NERV | Buy | MINERVA NEUROSCIENCES INC | $10,572,000 | +56.3% | 842,391 | +2.7% | 1.21% | +30.1% |
| CSTE | Buy | CAESARSTONE LTD | $10,412,000 | +198.8% | 561,311 | +143.2% | 1.20% | +149.0% |
| ARGX | New | ARGENX SEsponsored adr | $10,343,000 | – | 136,381 | +100.0% | 1.19% | – |
| PTCT | New | PTC THERAPEUTICS INC | $9,870,000 | – | 210,000 | +100.0% | 1.13% | – |
| RTRX | Sell | RETROPHIN INC | $9,357,000 | -2.8% | 325,678 | -7.8% | 1.07% | -19.1% |
| AUTL | Buy | AUTOLUS THERAPEUTICS PLCspon ads | $8,935,000 | +89.5% | 296,251 | +68.3% | 1.03% | +57.8% |
| BMRN | Buy | BIOMARIN PHARMACEUTICAL INC | $8,533,000 | +1348.7% | 88,000 | +1308.0% | 0.98% | +1109.9% |
| SAGE | New | SAGE THERAPEUTICS INC | $8,475,000 | – | 60,000 | +100.0% | 0.97% | – |
| MSFT | Sell | MICROSOFT CORP | $7,967,000 | +8.5% | 69,656 | -6.4% | 0.92% | -9.6% |
| PRQR | Sell | PROQR THRAPEUTICS N V | $7,716,000 | +114.1% | 398,749 | -19.2% | 0.89% | +78.3% |
| SRRK | Buy | SCHOLAR ROCK HLDG CORP | $7,644,000 | +72.6% | 296,856 | +4.5% | 0.88% | +43.7% |
| RETA | Sell | REATA PHARMACEUTICALS INCcl a | $7,581,000 | +59.4% | 92,719 | -31.8% | 0.87% | +32.6% |
| VRNT | New | VERINT SYS INC | $7,521,000 | – | 150,126 | +100.0% | 0.86% | – |
| CLSD | Buy | CLEARSIDE BIOMEDICAL INC | $7,101,000 | -37.8% | 1,154,690 | +8.0% | 0.82% | -48.3% |
| ASND | Buy | ASCENDIS PHARMA A Ssponsored adr | $6,567,000 | +26.5% | 92,673 | +18.7% | 0.75% | +5.3% |
| QURE | Buy | UNIQURE NV | $6,472,000 | +12.3% | 177,849 | +16.6% | 0.74% | -6.5% |
| MLNT | Buy | MELINTA THERAPEUTICS INC | $6,387,000 | +2.2% | 1,616,867 | +64.2% | 0.73% | -15.0% |
| AGLE | Buy | AEGLEA BIOTHERAPEUTICS INC | $6,250,000 | +16.0% | 653,112 | +28.3% | 0.72% | -3.4% |
| CARA | New | CARA THERAPEUTICS INC | $6,130,000 | – | 255,930 | +100.0% | 0.70% | – |
| V | VISA INC | $6,064,000 | +13.3% | 40,401 | 0.0% | 0.70% | -5.7% | |
| ARRY | Buy | ARRAY BIOPHARMA INC | $6,004,000 | +5.3% | 395,000 | +16.2% | 0.69% | -12.3% |
| BHVN | Buy | BIOHAVEN PHARMACTL HLDG CO L | $5,840,000 | +7.6% | 155,515 | +13.2% | 0.67% | -10.5% |
| SBBP | Buy | STRONGBRIDGE BIOPHARMA PLC | $5,718,000 | +41.4% | 1,179,010 | +74.9% | 0.66% | +17.6% |
| SEDG | Buy | SOLAREDGE TECHNOLOGIES INC | $5,678,000 | +142.4% | 150,817 | +208.1% | 0.65% | +101.9% |
| FIXX | Buy | HOMOLOGY MEDICINES INC | $5,603,000 | +93.7% | 245,104 | +72.8% | 0.64% | +61.2% |
| WAB | Buy | WABTEC CORP | $5,571,000 | +21.4% | 53,114 | +14.1% | 0.64% | +1.1% |
| MRTX | Buy | MIRATI THERAPEUTICS INC | $5,318,000 | +652.2% | 112,908 | +687.6% | 0.61% | +529.9% |
| IFF | New | INTERNATIONAL FLAVORS&FRAGRA | $5,071,000 | – | 36,450 | +100.0% | 0.58% | – |
| PIRS | Buy | PIERIS PHARMACEUTICALS INC | $5,066,000 | +18.6% | 904,686 | +7.4% | 0.58% | -1.2% |
| MA | MASTERCARD INCORPORATEDcl a | $5,067,000 | +13.3% | 22,760 | 0.0% | 0.58% | -5.7% | |
| ZFGN | Sell | ZAFGEN INC | $5,027,000 | +2.4% | 430,000 | -10.4% | 0.58% | -14.8% |
| XENE | Sell | XENON PHARMACEUTICALS INC | $5,009,000 | +24.0% | 379,484 | -13.6% | 0.58% | +3.2% |
| KDMN | Sell | KADMON HLDGS INC | $4,977,000 | -19.7% | 1,490,000 | -4.0% | 0.57% | -33.1% |
| CSCO | CISCO SYS INC | $4,865,000 | +13.1% | 100,000 | 0.0% | 0.56% | -5.7% | |
| BOLD | New | AUDENTES THERAPEUTICS INC | $4,751,000 | – | 120,000 | +100.0% | 0.54% | – |
| FSCT | Buy | FORESCOUT TECHNOLOGIES INC | $4,700,000 | +79.6% | 124,463 | +62.9% | 0.54% | +49.6% |
| KZR | Sell | KEZAR LIFE SCIENCES INC | $4,539,000 | +15.1% | 212,000 | -7.0% | 0.52% | -4.2% |
| OBSV | OBSEVA SA | $4,393,000 | +19.1% | 243,669 | 0.0% | 0.50% | -1.0% | |
| ABEO | Buy | ABEONA THERAPEUTICS INC | $4,313,000 | +20.8% | 336,939 | +51.0% | 0.50% | +0.6% |
| TEVA | New | TEVA PHARMACEUTICAL INDS LTDsponsored adr | $4,308,000 | – | 200,000 | +100.0% | 0.50% | – |
| CTMX | Buy | CYTOMX THERAPEUTICS INC | $4,313,000 | +126.9% | 233,151 | +180.4% | 0.50% | +88.9% |
| DCPH | Buy | DECIPHERA PHARMACEUTICALS IN | $4,260,000 | +16.4% | 110,033 | +18.3% | 0.49% | -3.2% |
| EPZM | Buy | EPIZYME INC | $4,235,000 | +1.8% | 399,502 | +30.1% | 0.49% | -15.3% |
| EVOK | EVOKE PHARMA INC | $4,205,000 | +19.2% | 1,410,946 | 0.0% | 0.48% | -0.6% | |
| STRO | New | SUTRO BIOPHARMA INC | $4,125,000 | – | 275,000 | +100.0% | 0.47% | – |
| ARVN | New | ARVINAS INC | $4,049,000 | – | 240,000 | +100.0% | 0.46% | – |
| NEOS | Buy | NEOS THERAPEUTICS INC | $4,034,000 | +83.3% | 831,697 | +136.2% | 0.46% | +52.8% |
| ACIU | New | AC IMMUNE SA | $4,029,000 | – | 503,563 | +100.0% | 0.46% | – |
| SNA | Buy | SNAP ON INC | $3,978,000 | +1708.2% | 21,666 | +1486.1% | 0.46% | +1423.3% |
| IDRA | New | IDERA PHARMACEUTICALS INC | $3,970,000 | – | 445,558 | +100.0% | 0.46% | – |
| GOOGL | ALPHABET INCcap stk cl a | $3,946,000 | +6.9% | 3,269 | 0.0% | 0.45% | -11.0% | |
| PTLA | Buy | PORTOLA PHARMACEUTICALS INC | $3,915,000 | +182.7% | 147,000 | +22.5% | 0.45% | +135.1% |
| APLS | Buy | APELLIS PHARMACEUTICALS INC | $3,778,000 | +55.0% | 212,470 | +91.8% | 0.43% | +29.2% |
| ORLY | O REILLY AUTOMOTIVE INC NEW | $3,766,000 | +26.9% | 10,844 | 0.0% | 0.43% | +5.6% | |
| ASMB | New | ASSEMBLY BIOSCIENCES INC | $3,730,000 | – | 100,431 | +100.0% | 0.43% | – |
| MLNX | Sell | MELLANOX TECHNOLOGIES LTD | $3,679,000 | -49.2% | 50,093 | -41.7% | 0.42% | -57.8% |
| GLYC | Buy | GLYCOMIMETICS INC | $3,615,000 | -6.6% | 251,013 | +4.6% | 0.42% | -22.3% |
| ALNY | Sell | ALNYLAM PHARMACEUTICALS INC | $3,501,000 | -81.8% | 40,000 | -79.5% | 0.40% | -84.8% |
| ARPO | Buy | AERPIO PHARMACEUTICALS INC | $3,497,000 | -23.6% | 1,131,819 | +2.6% | 0.40% | -36.5% |
| ALNA | Buy | ALLENA PHARMACEUTICALS INC | $3,170,000 | -9.0% | 295,199 | +10.4% | 0.36% | -24.2% |
| TBIO | Buy | TRANSLATE BIO INC | $2,766,000 | +68.1% | 276,639 | +112.8% | 0.32% | +40.1% |
| CRVS | Sell | CORVUS PHARMACEUTICALS INC | $2,758,000 | -25.2% | 321,430 | -4.3% | 0.32% | -37.7% |
| LPTX | Sell | LEAP THERAPEUTICS INC | $2,590,000 | -42.3% | 332,525 | -33.4% | 0.30% | -52.0% |
| DOVA | New | DOVA PHARMACEUTICALS INC | $2,516,000 | – | 120,000 | +100.0% | 0.29% | – |
| VTGN | Buy | VISTAGEN THERAPEUTICS INC | $2,427,000 | +29.2% | 1,673,918 | +22.0% | 0.28% | +7.7% |
| SVRA | New | SAVARA INC | $2,339,000 | – | 209,596 | +100.0% | 0.27% | – |
| ALLT | New | ALLOT COMMUNICATIONS LTD | $2,326,000 | – | 376,451 | +100.0% | 0.27% | – |
| MTEM | New | MOLECULAR TEMPLATES INC | $2,156,000 | – | 400,000 | +100.0% | 0.25% | – |
| FLEX | Sell | FLEX LTDord | $2,093,000 | -42.9% | 159,549 | -38.6% | 0.24% | -52.5% |
| UROV | New | UROVANT SCIENCES LTD | $1,968,000 | – | 164,030 | +100.0% | 0.23% | – |
| VRCA | Sell | VERRICA PHARMACEUTICALS INC | $1,901,000 | -23.4% | 117,000 | -7.0% | 0.22% | -36.3% |
| SRRA | Sell | SIERRA ONCOLOGY INC | $1,739,000 | -45.4% | 1,022,759 | -4.9% | 0.20% | -54.4% |
| AQST | New | AQUESTIVE THERAPEUTICS INC | $1,669,000 | – | 95,300 | +100.0% | 0.19% | – |
| GILT | GILAT SATELLITE NETWORKS LTD | $1,398,000 | -6.9% | 163,367 | 0.0% | 0.16% | -22.7% | |
| SESN | Sell | SESEN BIO INC | $1,355,000 | -70.8% | 630,000 | -73.5% | 0.16% | -75.6% |
| ZYME | ZYMEWORKS INC | $1,159,000 | +6.2% | 73,800 | 0.0% | 0.13% | -11.3% | |
| ERYP | New | ERYTECH PHARMAsponsored adr | $1,046,000 | – | 120,000 | +100.0% | 0.12% | – |
| AAP | ADVANCE AUTO PARTS INC | $898,000 | +24.0% | 5,336 | 0.0% | 0.10% | +3.0% | |
| TEVA PHARMACEUTICAL FIN LLCdbcv 0.250% 2/0 | $862,000 | -11.1% | 2,135 | 0.0% | 0.10% | -26.1% | ||
| AUDC | AUDIOCODES LTDord | $596,000 | +29.3% | 59,226 | 0.0% | 0.07% | +6.2% | |
| UNH | UNITEDHEALTH GROUP INC | $532,000 | +8.4% | 2,000 | 0.0% | 0.06% | -10.3% | |
| RDWR | RADWARE LTDord | $464,000 | +4.7% | 17,527 | 0.0% | 0.05% | -13.1% | |
| CHTR | CHARTER COMMUNICATIONS INC Ncl a | $462,000 | +11.1% | 1,419 | 0.0% | 0.05% | -7.0% | |
| ADVM | New | ADVERUM BIOTECHNOLOGIES INC | $454,000 | – | 75,000 | +100.0% | 0.05% | – |
| VKTX | New | VIKING THERAPEUTICS INCcall | $416,000 | – | 23,900 | +100.0% | 0.05% | – |
| SERV | SERVICEMASTER GLOBAL HLDGS I | $395,000 | -30.1% | 9,500 | 0.0% | 0.04% | -42.3% | |
| ABUS | New | ARBUTUS BIOPHARMA CORP | $378,000 | – | 40,000 | +100.0% | 0.04% | – |
| New | NICE SYS INCnote 1.250% 1/1 | $359,000 | – | 250,000 | +100.0% | 0.04% | – | |
| EIDX | Buy | EIDOS THERAPEUTICS INC | $315,000 | +43.2% | 31,522 | +191.1% | 0.04% | +20.0% |
| BNTC | New | BENITEC BIOPHARMA LTDspons adr new | $294,000 | – | 120,000 | +100.0% | 0.03% | – |
| LOW | New | LOWES COS INC | $287,000 | – | 2,500 | +100.0% | 0.03% | – |
| CLRB | New | CELLECTAR BIOSCIENCES INC | $263,000 | – | 87,500 | +100.0% | 0.03% | – |
| ULTI | ULTIMATE SOFTWARE GROUP INC | $258,000 | +25.2% | 800 | 0.0% | 0.03% | +7.1% | |
| CISN | CISION LTD | $252,000 | +12.5% | 15,000 | 0.0% | 0.03% | -6.5% | |
| SITE | SITEONE LANDSCAPE SUPPLY INC | $226,000 | -10.3% | 3,000 | 0.0% | 0.03% | -25.7% | |
| CMCSA | New | COMCAST CORP NEWcl a | $212,000 | – | 5,993 | +100.0% | 0.02% | – |
| CUE | New | CUE BIOPHARMA INC | $181,000 | – | 20,000 | +100.0% | 0.02% | – |
| KMPH | Exit | KEMPHARM INC | $0 | – | -22,622 | -100.0% | -0.02% | – |
| MHK | Exit | MOHAWK INDS INC | $0 | – | -1,100 | -100.0% | -0.03% | – |
| TCDA | Exit | TRICIDA INC | $0 | – | -20,410 | -100.0% | -0.08% | – |
| RCKT | Exit | ROCKET PHARMACEUTICALS INC | $0 | – | -34,475 | -100.0% | -0.09% | – |
| AQXP | Exit | AQUINOX PHARMACEUTICALS INC | $0 | – | -257,613 | -100.0% | -0.09% | – |
| RDCM | Exit | RADCOM LTD | $0 | – | -52,760 | -100.0% | -0.14% | – |
| DK | Exit | DELEK US HLDGS INC NEW | $0 | – | -24,533 | -100.0% | -0.17% | – |
| KRNT | Exit | KORNIT DIGITAL LTD | $0 | – | -130,831 | -100.0% | -0.32% | – |
| MRVL | Exit | MARVELL TECHNOLOGY GROUP LTDord | $0 | – | -109,842 | -100.0% | -0.32% | – |
| APTX | Exit | APTINYX INC | $0 | – | -102,474 | -100.0% | -0.34% | – |
| LRCX | Exit | LAM RESEARCH CORP | $0 | – | -14,597 | -100.0% | -0.35% | – |
| ELOX | Exit | ELOXX PHARMACEUTICALS INC | $0 | – | -167,474 | -100.0% | -0.39% | – |
| WIX | Exit | WIX COM LTD | $0 | – | -29,542 | -100.0% | -0.41% | – |
| VRTX | Exit | VERTEX PHARMACEUTICALS INC | $0 | – | -20,000 | -100.0% | -0.47% | – |
| FB | Exit | FACEBOOK INCcl a | $0 | – | -19,100 | -100.0% | -0.51% | – |
| CTIC | Exit | CTI BIOPHARMA CORP | $0 | – | -874,407 | -100.0% | -0.60% | – |
| ADMS | Exit | ADAMAS PHARMACEUTICALS INC | $0 | – | -213,625 | -100.0% | -0.76% | – |
| NICE | Exit | NICE LTDsponsored adr | $0 | – | -60,043 | -100.0% | -0.86% | – |
| SODA | Exit | SODASTREAM INTERNATIONAL LTD | $0 | – | -73,762 | -100.0% | -0.87% | – |
| KURA | Exit | KURA ONCOLOGY INC | $0 | – | -351,953 | -100.0% | -0.88% | – |
| INNT | Exit | INNOVATE BIOPHARMACEUTICLS I | $0 | – | -980,502 | -100.0% | -1.08% | – |
| AGN | Exit | ALLERGAN PLC | $0 | – | -60,000 | -100.0% | -1.38% | – |
| PFE | Exit | PFIZER INC | $0 | – | -390,000 | -100.0% | -1.95% | – |
| BIIB | Exit | BIOGEN INC | $0 | – | -50,000 | -100.0% | -2.00% | – |
| AMGN | Exit | AMGEN INC | $0 | – | -100,000 | -100.0% | -2.54% | – |
| SHPG | Exit | SHIRE PLCsponsored adr | $0 | – | -126,500 | -100.0% | -2.94% | – |
| Exit | ISHARES TRput | $0 | – | -150,000 | -100.0% | -3.39% | – | |
| Exit | SPDR SERIES TRUSTput | $0 | – | -750,000 | -100.0% | -9.84% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2018-11-14
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| TEVA PHARMACEUTICAL-SP ADR | 36 | Q3 2023 | 8.4% |
| MERCK & CO INC NEW | 35 | Q3 2023 | 8.4% |
| NICE Systems Ltd | 27 | Q3 2023 | 4.4% |
| BIOGEN INC | 26 | Q3 2023 | 6.7% |
| AMICUS THERAPEUTICS INC | 26 | Q2 2022 | 4.3% |
| PFIZER INC | 25 | Q3 2023 | 9.2% |
| SAREPTA THERAPEUTICS INC | 25 | Q3 2023 | 3.2% |
| JOHNSON & JOHNSON | 24 | Q3 2023 | 8.0% |
| UNIQURE NV | 23 | Q3 2023 | 1.2% |
| SYNDAX PHARMACEUTICALS INC | 22 | Q3 2023 | 3.9% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Cyclacel Pharmaceuticals, Inc. | February 06, 2023 | 250,000 | 2.0% |
| Altimmune, Inc. | February 14, 2022 | 1,244,241 | 3.1% |
| Allot Ltd. | February 16, 2021 | 1,129,054 | 3.2% |
| Larimar Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Neos Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Orgenesis Inc. | February 16, 2021 | 525,216 | 0.0% |
| Sio Gene Therapies Inc. | February 16, 2021 | ? | ? |
| X4 Pharmaceuticals, Inc | February 16, 2021 | 250,000 | 0.0% |
| Axovant Gene Therapies Ltd. | February 25, 2020 | 2,931,017 | 8.0% |
| Axovant Gene Therapies Ltd. | February 11, 2020 | 398,540 | 1.8% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 13F-HR/A | 2024-02-15 |
| 13F-HR | 2024-02-14 |
| SC 13G | 2024-02-08 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| 13F-HR | 2023-11-14 |
| SC 13G | 2023-10-10 |
| SC 13G | 2023-08-30 |
View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.