SPHERA FUNDS MANAGEMENT LTD. - Q1 2019 holdings

Add to watchlist

$1.1 Billion is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 104 reported holdings in Q1 2019. The portfolio turnover from Q4 2018 to Q1 2019 was 68.0% .

All

			Value		Shares		↓ Weighting
XBI	Buy	SPDR SERIES TRUSTput	$301,951,000	+55.9%	3,335,000	+23.5%	27.56%	+26.2%
BMY	Buy	BRISTOL MYERS SQUIBB CO	$41,980,000	+28.2%	879,900	+39.7%	3.83%	+3.8%
JNJ	New	JOHNSON & JOHNSON	$37,044,000	–	265,000	+100.0%	3.38%	–
FOLD	Buy	AMICUS THERAPEUTICS INC	$33,838,000	+44.3%	2,488,078	+1.6%	3.09%	+16.9%
ALXN	Buy	ALEXION PHARMACEUTICALS INC	$33,430,000	+104.3%	247,300	+47.1%	3.05%	+65.4%
MRK	Sell	MERCK & CO INC	$31,355,000	-13.1%	377,000	-20.1%	2.86%	-29.6%
GILD	Buy	GILEAD SCIENCES INC	$31,205,000	+42.5%	480,000	+37.1%	2.85%	+15.4%
MYL	Sell	MYLAN N V	$28,405,000	-38.2%	1,002,307	-40.2%	2.59%	-49.9%
AZN	Buy	ASTRAZENECA PLCsponsored adr	$28,301,000	+44.7%	700,000	+35.9%	2.58%	+17.1%
CELG	New	CELGENE CORPput	$28,302,000	–	300,000	+100.0%	2.58%	–
CELG	Sell	CELGENE CORP	$23,585,000	-20.9%	250,000	-46.2%	2.15%	-35.9%
NVO	New	NOVO-NORDISK A Sadr	$20,924,000	–	400,000	+100.0%	1.91%	–
GSK	Buy	GLAXOSMITHKLINE PLCsponsored adr	$17,970,000	+51.7%	430,000	+38.7%	1.64%	+22.8%
VRNT	Buy	VERINT SYS INC	$15,799,000	-33.0%	263,926	+77.0%	1.44%	-45.7%
BIIB	New	BIOGEN INCput	$14,183,000	–	60,000	+100.0%	1.30%	–
BLUE	Sell	BLUEBIRD BIO INC	$13,184,000	-4.2%	83,796	-39.6%	1.20%	-22.5%
QURE	New	UNIQURE NVcall	$11,930,000	–	200,000	+100.0%	1.09%	–
URGN	New	UROGEN PHARMA LTD	$11,391,000	–	308,377	+100.0%	1.04%	–
ICPT	New	INTERCEPT PHARMACEUTICALS IN	$11,186,000	–	100,000	+100.0%	1.02%	–
RTRX	Buy	RETROPHIN INC	$9,859,000	+33.8%	435,678	+33.8%	0.90%	+8.3%
ALDX	Sell	ALDEYRA THERAPEUTICS INC	$9,654,000	-5.6%	1,069,089	-13.2%	0.88%	-23.6%
NVS	New	NOVARTIS A Gsponsored adr	$9,614,000	–	100,000	+100.0%	0.88%	–
SRPT	Sell	SAREPTA THERAPEUTICS INC	$8,749,000	-31.2%	73,405	-37.0%	0.80%	-44.2%
PTCT	Sell	PTC THERAPEUTICS INC	$8,300,000	-30.0%	220,500	-36.2%	0.76%	-43.3%
CLLS		CELLECTIS S Asponsored ads	$8,216,000	+10.1%	447,970	0.0%	0.75%	-10.8%
ASND	Buy	ASCENDIS PHARMA A Ssponsored adr	$8,036,000	+120.1%	68,273	+17.2%	0.73%	+77.9%
AGLE	Buy	AEGLEA BIOTHERAPEUTICS INC	$7,849,000	+74.7%	975,000	+62.5%	0.72%	+41.2%
ALLT	Buy	ALLOT COMMUNICATIONS LTD	$7,669,000	-43.2%	965,931	+62.1%	0.70%	-54.0%
PANW	Buy	PALO ALTO NETWORKS INC	$7,470,000	-57.3%	30,754	+23.6%	0.68%	-65.5%
CSTE	Buy	CAESARSTONE LTD	$7,463,000	-68.7%	478,114	+1.9%	0.68%	-74.6%
MSFT	Buy	MICROSOFT CORP	$7,241,000	-59.4%	61,397	+30.6%	0.66%	-67.1%
AERI	New	AERIE PHARMACEUTICALS INC	$7,125,000	–	150,000	+100.0%	0.65%	–
BIIB	New	BIOGEN INC	$7,091,000	–	30,000	+100.0%	0.65%	–
RETA	Sell	REATA PHARMACEUTICALS INCcl a	$6,989,000	-43.7%	81,769	-63.0%	0.64%	-54.4%
ARQL	Sell	ARQULE INC	$6,862,000	+21.9%	1,432,643	-29.5%	0.63%	-1.4%
AXGT	Sell	AXOVANT SCIENCES LTD	$6,794,000	-16.8%	5,108,333	-37.7%	0.62%	-32.7%
IMMU	Sell	IMMUNOMEDICS INC	$6,275,000	-37.8%	326,660	-53.8%	0.57%	-49.6%
CAMT	New	CAMTEK LTDord	$6,249,000	–	700,574	+100.0%	0.57%	–
AUTL	Sell	AUTOLUS THERAPEUTICS PLCspon ads	$6,074,000	-8.9%	192,994	-4.9%	0.55%	-26.2%
KRYS	Buy	KRYSTAL BIOTECH INC	$5,975,000	+64.6%	181,625	+4.0%	0.54%	+33.3%
CARA		CARA THERAPEUTICS INC	$5,963,000	+50.9%	303,930	0.0%	0.54%	+22.2%
GOOGL	New	ALPHABET INCcap stk cl a	$5,884,000	–	5,000	+100.0%	0.54%	–
MYOK	New	MYOKARDIA INC	$5,875,000	–	113,000	+100.0%	0.54%	–
MLNX	Buy	MELLANOX TECHNOLOGIES LTD	$5,846,000	-40.3%	49,394	+74.2%	0.53%	-51.6%
NEOS		NEOS THERAPEUTICS INC	$5,746,000	+58.2%	2,201,697	0.0%	0.52%	+28.1%
XENE	Buy	XENON PHARMACEUTICALS INC	$5,422,000	+91.2%	533,655	+18.7%	0.50%	+54.7%
AMZN	New	AMAZON COM INC	$5,342,000	–	3,000	+100.0%	0.49%	–
ANAB	New	ANAPTYSBIO INC	$5,114,000	–	70,000	+100.0%	0.47%	–
RCKT		ROCKET PHARMACEUTICALS INC	$5,087,000	+18.4%	290,001	0.0%	0.46%	-4.1%
NERV	Sell	MINERVA NEUROSCIENCES INC	$5,046,000	-4.3%	642,018	-17.9%	0.46%	-22.4%
STRO	Buy	SUTRO BIOPHARMA INC	$4,988,000	+35.6%	437,889	+7.4%	0.46%	+9.6%
SBBP	Buy	STRONGBRIDGE BIOPHARMA PLC	$4,739,000	+13.5%	951,600	+2.1%	0.43%	-7.9%
MHK	Buy	MOHAWK INDS INC	$4,668,000	+0.2%	37,000	+247.1%	0.43%	-18.9%
QURE	Sell	UNIQURE NV	$4,614,000	-31.2%	77,349	-66.8%	0.42%	-44.3%
CBAY	New	CYMABAY THERAPEUTICS INC	$4,589,000	–	345,535	+100.0%	0.42%	–
MLNX	New	MELLANOX TECHNOLOGIES LTDput	$4,557,000	–	38,500	+100.0%	0.42%	–
BHVN	Sell	BIOHAVEN PHARMACTL HLDG CO L	$4,530,000	-7.9%	88,015	-33.8%	0.41%	-25.5%
SEDG	New	SOLAREDGE TECHNOLOGIES INC	$4,486,000	–	119,067	+100.0%	0.41%	–
FIXX		HOMOLOGY MEDICINES INC	$4,465,000	+24.0%	161,000	0.0%	0.41%	+0.5%
MGNX	New	MACROGENICS INC	$4,225,000	–	235,000	+100.0%	0.39%	–
GBT	Sell	GLOBAL BLOOD THERAPEUTICS IN	$4,234,000	-29.8%	80,000	-45.6%	0.39%	-43.2%
ARGX	Sell	ARGENX SEsponsored adr	$4,192,000	-49.9%	33,581	-61.4%	0.38%	-59.4%
XHB	New	SPDR SERIES TRUSTs&p homebuild	$4,161,000	–	107,934	+100.0%	0.38%	–
LOGC		LOGICBIO THERAPEUTICS INC	$4,126,000	-5.0%	417,625	0.0%	0.38%	-23.1%
DTIL	New	PRECISION BIOSCIENCES INC	$4,039,000	–	225,000	+100.0%	0.37%	–
KDMN		KADMON HLDGS INC	$3,934,000	+26.9%	1,490,000	0.0%	0.36%	+2.9%
NICE	New	NICE LTDsponsored adr	$3,892,000	–	31,771	+100.0%	0.36%	–
GLYC	Buy	GLYCOMIMETICS INC	$3,875,000	+63.0%	311,013	+23.9%	0.35%	+32.1%
TLT	New	ISHARES TR20 yr tr bd etf	$3,793,000	–	30,000	+100.0%	0.35%	–
ITCI	New	INTRA CELLULAR THERAPIES INCcall	$3,654,000	–	300,000	+100.0%	0.33%	–
FISV	New	FISERV INC	$3,563,000	–	40,365	+100.0%	0.32%	–
ORTX	Sell	ORCHARD THERAPEUTICS PLCads	$3,536,000	-39.2%	197,786	-46.5%	0.32%	-50.8%
FSCT	Buy	FORESCOUT TECHNOLOGIES INC	$3,169,000	-44.8%	75,625	+27.8%	0.29%	-55.4%
HARP	New	HARPOON THERAPEUTICS INC	$3,133,000	–	330,800	+100.0%	0.29%	–
OSMT	Sell	OSMOTICA PHARMACEUTICALS PLC	$3,110,000	-56.5%	864,006	-6.3%	0.28%	-64.8%
ALNA	Buy	ALLENA PHARMACEUTICALS INC	$3,027,000	+60.9%	431,193	+24.9%	0.28%	+30.2%
AAP	New	ADVANCE AUTO PARTS INC	$2,967,000	–	17,400	+100.0%	0.27%	–
WAB	New	WABTEC CORP	$2,949,000	–	40,000	+100.0%	0.27%	–
ARVN	Sell	ARVINAS INC	$2,923,000	-16.1%	198,053	-26.9%	0.27%	-32.1%
DCPH		DECIPHERA PHARMACEUTICALS IN	$2,670,000	+10.6%	115,033	0.0%	0.24%	-10.3%
PRQR	Sell	PROQR THRAPEUTICS N V	$2,635,000	-50.9%	190,000	-44.1%	0.24%	-60.2%
AUDC	New	AUDIOCODES LTDord	$2,589,000	–	187,045	+100.0%	0.24%	–
VTGN	Buy	VISTAGEN THERAPEUTICS INC	$2,588,000	+17.1%	2,022,066	+37.2%	0.24%	-5.2%
RDWR	New	RADWARE LTDord	$2,150,000	–	82,277	+100.0%	0.20%	–
ARYA		ARYA SCIENCES ACQUISITION CO	$2,070,000	+1.1%	200,000	0.0%	0.19%	-18.2%
CTMX	Sell	CYTOMX THERAPEUTICS INC	$1,969,000	-52.3%	183,151	-32.9%	0.18%	-61.3%
GILT	Buy	GILAT SATELLITE NETWORKS LTD	$1,482,000	-74.0%	176,406	+5.8%	0.14%	-79.0%
KRNT	Buy	KORNIT DIGITAL LTD	$1,461,000	-31.1%	61,404	+102.4%	0.13%	-44.4%
TOCA	New	TOCAGEN INC	$1,304,000	–	120,000	+100.0%	0.12%	–
ACER	New	ACER THERAPEUTICS INC	$1,215,000	–	50,000	+100.0%	0.11%	–
DK	New	DELEK US HLDGS INC NEW	$1,098,000	–	30,157	+100.0%	0.10%	–
MRSN	New	MERSANA THERAPEUTICS INC	$1,052,000	–	200,000	+100.0%	0.10%	–
CHRS	New	COHERUS BIOSCIENCES INC	$1,031,000	–	75,600	+100.0%	0.09%	–
ERYP		ERYTECH PHARMAsponsored adr	$912,000	+14.6%	120,000	0.0%	0.08%	-7.8%
TEVA	Sell	TEVA PHARMACEUTICAL INDS LTDsponsored adr	$844,000	-92.2%	53,834	-92.4%	0.08%	-93.7%
MGTX	Sell	MEIRAGTX HOLDINGS PLC	$623,000	-9.2%	36,159	-49.2%	0.06%	-26.0%
CNST	Sell	CONSTELLATION PHARMCETICLS I	$544,000	+93.6%	40,162	-42.8%	0.05%	+56.2%
SBPH		SPRING BK PHARMACEUTICALS IN	$535,000	+0.9%	51,015	0.0%	0.05%	-18.3%
CUE		CUE BIOPHARMA INC	$387,000	+64.7%	50,000	0.0%	0.04%	+34.6%
		NICE SYS INCnote 1.250% 1/1	$376,000	-70.8%	250,000	0.0%	0.03%	-76.6%
CRVS	Sell	CORVUS PHARMACEUTICALS INC	$336,000	-71.5%	83,607	-74.0%	0.03%	-76.7%
MGIC	New	MAGIC SOFTWARE ENTERPRISES Lord	$324,000	–	38,784	+100.0%	0.03%	–
BNTC		BENITEC BIOPHARMA LTDspons adr new	$228,000	+26.7%	120,000	0.0%	0.02%	+5.0%
CLRB		CELLECTAR BIOSCIENCES INC	$206,000	+51.5%	87,500	0.0%	0.02%	+26.7%
ADVM	Exit	ADVERUM BIOTECHNOLOGIES INC	$0	–	-63,355	-100.0%	-0.02%	–
SRRA	Exit	SIERRA ONCOLOGY INC	$0	–	-258,510	-100.0%	-0.04%	–
KZR	Exit	KEZAR LIFE SCIENCES INC	$0	–	-20,000	-100.0%	-0.05%	–
VRCA	Exit	VERRICA PHARMACEUTICALS INC	$0	–	-97,000	-100.0%	-0.09%	–
SVRA	Exit	SAVARA INC	$0	–	-110,000	-100.0%	-0.09%	–
IDRA	Exit	IDERA PHARMACEUTICALS INC	$0	–	-445,558	-100.0%	-0.14%	–
CLSD	Exit	CLEARSIDE BIOMEDICAL INC	$0	–	-1,185,124	-100.0%	-0.14%	–
MLNT	Exit	MELINTA THERAPEUTICS INC	$0	–	-1,616,867	-100.0%	-0.14%	–
DOVA	Exit	DOVA PHARMACEUTICALS INC	$0	–	-185,000	-100.0%	-0.16%	–
UROV	Exit	UROVANT SCIENCES LTD	$0	–	-214,030	-100.0%	-0.16%	–
APLS	Exit	APELLIS PHARMACEUTICALS INC	$0	–	-117,000	-100.0%	-0.17%	–
MTEM	Exit	MOLECULAR TEMPLATES INC	$0	–	-400,000	-100.0%	-0.18%	–
ARRY	Exit	ARRAY BIOPHARMA INC	$0	–	-125,000	-100.0%	-0.20%	–
PIRS	Exit	PIERIS PHARMACEUTICALS INC	$0	–	-700,000	-100.0%	-0.21%	–
ZFGN	Exit	ZAFGEN INC	$0	–	-380,000	-100.0%	-0.21%	–
ARPO	Exit	AERPIO PHARMACEUTICALS INC	$0	–	-1,131,819	-100.0%	-0.22%	–
ABEO	Exit	ABEONA THERAPEUTICS INC	$0	–	-270,036	-100.0%	-0.22%	–
TBIO	Exit	TRANSLATE BIO INC	$0	–	-309,400	-100.0%	-0.26%	–
SAGE	Exit	SAGE THERAPEUTICS INCput	$0	–	-24,500	-100.0%	-0.26%	–
PTLA	Exit	PORTOLA PHARMACEUTICALS INC	$0	–	-147,000	-100.0%	-0.32%	–
ACIU	Exit	AC IMMUNE SA	$0	–	-310,613	-100.0%	-0.33%	–
ALLO	Exit	ALLOGENE THERAPEUTICS INC	$0	–	-113,437	-100.0%	-0.34%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INC	$0	–	-67,500	-100.0%	-0.35%	–
XBI	Exit	SPDR SERIES TRUSTs&p biotech	$0	–	-45,000	-100.0%	-0.36%	–
EVOK	Exit	EVOKE PHARMA INC	$0	–	-1,410,946	-100.0%	-0.39%	–
SGMO	Exit	SANGAMO THERAPEUTICS INC	$0	–	-340,000	-100.0%	-0.44%	–
SRRK	Exit	SCHOLAR ROCK HLDG CORP	$0	–	-175,511	-100.0%	-0.45%	–
EPZM	Exit	EPIZYME INC	$0	–	-749,502	-100.0%	-0.52%	–
VKTX	Exit	VIKING THERAPEUTICS INC	$0	–	-745,727	-100.0%	-0.64%	–
GWPH	Exit	GW PHARMACEUTICALS PLCads	$0	–	-77,000	-100.0%	-0.84%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-103,500	-100.0%	-1.12%	–
ITRN	Exit	ITURAN LOCATION AND CONTROL	$0	–	-122,177	-100.0%	-1.65%	–

Other managers

Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):

Original filings

The following EDGAR filing(s) were analyzed to create this report:

View 13F-HR filed 2019-05-15
View 13F-HR/A filed 2019-06-20

Signatures

The EDGAR filing(s) were signed by:

Top long-term holdings

Name	Quarters owned	Latest quarter owned	Max weighting
TEVA PHARMACEUTICAL-SP ADR	36	Q3 2023	8.4%
MERCK & CO INC NEW	35	Q3 2023	8.4%
NICE Systems Ltd	27	Q3 2023	4.4%
BIOGEN INC	26	Q3 2023	6.7%
AMICUS THERAPEUTICS INC	26	Q2 2022	4.3%
PFIZER INC	25	Q3 2023	9.2%
SAREPTA THERAPEUTICS INC	25	Q3 2023	3.2%
JOHNSON & JOHNSON	24	Q3 2023	8.0%
UNIQURE NV	23	Q3 2023	1.2%
SYNDAX PHARMACEUTICALS INC	22	Q3 2023	3.9%

View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.

Latest significant ownerships (13-D/G)

SPHERA FUNDS MANAGEMENT LTD. Q1 2019 significant holdings filed using form 13D/G when ownership exceeds 5% of a company's total stock issue.
	Filed	Shares	Percentage
Cyclacel Pharmaceuticals, Inc.	February 06, 2023	250,000	2.0%
Altimmune, Inc.	February 14, 2022	1,244,241	3.1%
Allot Ltd.	February 16, 2021	1,129,054	3.2%
Larimar Therapeutics, Inc.	February 16, 2021	?	?
Neos Therapeutics, Inc.	February 16, 2021	?	?
Orgenesis Inc.	February 16, 2021	525,216	0.0%
Sio Gene Therapies Inc.	February 16, 2021	?	?
X4 Pharmaceuticals, Inc	February 16, 2021	250,000	0.0%
Axovant Gene Therapies Ltd.	February 25, 2020	2,931,017	8.0%
Axovant Gene Therapies Ltd.	February 11, 2020	398,540	1.8%

View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.

Latest filings

Type	Filed
13F-HR/A	2024-02-15
13F-HR	2024-02-14
SC 13G	2024-02-08
SC 13G/A	2024-02-05
SC 13G/A	2024-02-05
SC 13G/A	2024-02-05
SC 13G/A	2024-02-05
13F-HR	2023-11-14
SC 13G	2023-10-10
SC 13G	2023-08-30

View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.

All filings

View complete filings history.

Compare quarters

Issues

The following issues were detected while analyzing the report:

The reported total value is incorrect (1095613000.0 != 1095609000.0)
The reported has been amended

Export SPHERA FUNDS MANAGEMENT LTD.'s holdings