$725 Million is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 110 reported holdings in Q2 2018. The portfolio turnover from Q1 2018 to Q2 2018 was 69.2% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| New | SPDR SERIES TRUSTput | $71,393,000 | – | 750,000 | +100.0% | 9.84% | – | |
| MRK | Buy | MERCK & CO INC | $41,276,000 | +30.6% | 680,000 | +17.2% | 5.69% | +18.6% |
| MYL | Buy | MYLAN N V | $30,864,000 | +30.6% | 854,000 | +48.8% | 4.26% | +18.6% |
| GSK | Buy | GLAXOSMITHKLINE PLCsponsored adr | $30,837,000 | +57.9% | 765,000 | +53.0% | 4.25% | +43.3% |
| GILD | New | GILEAD SCIENCES INC | $25,148,000 | – | 355,000 | +100.0% | 3.47% | – |
| New | ISHARES TRput | $24,566,000 | – | 150,000 | +100.0% | 3.39% | – | |
| SHPG | Sell | SHIRE PLCsponsored adr | $21,353,000 | -27.3% | 126,500 | -35.6% | 2.94% | -33.9% |
| ALXN | Buy | ALEXION PHARMACEUTICALS INC | $19,932,000 | +118.1% | 160,544 | +95.8% | 2.75% | +98.0% |
| ALNY | New | ALNYLAM PHARMACEUTICALS INC | $19,228,000 | – | 195,232 | +100.0% | 2.65% | – |
| SRPT | Sell | SAREPTA THERAPEUTICS INC | $19,179,000 | +4.0% | 145,096 | -41.7% | 2.64% | -5.6% |
| FOLD | Sell | AMICUS THERAPEUTICS INC | $18,573,000 | -33.1% | 1,189,056 | -35.6% | 2.56% | -39.2% |
| AMGN | New | AMGEN INC | $18,459,000 | – | 100,000 | +100.0% | 2.54% | – |
| BIIB | Sell | BIOGEN INC | $14,512,000 | -18.5% | 50,000 | -23.1% | 2.00% | -25.9% |
| PFE | Sell | PFIZER INC | $14,149,000 | -32.4% | 390,000 | -33.9% | 1.95% | -38.6% |
| CLSD | Buy | CLEARSIDE BIOMEDICAL INC | $11,425,000 | +3.4% | 1,068,720 | +3.8% | 1.58% | -6.1% |
| BLUE | New | BLUEBIRD BIO INC | $11,376,000 | – | 72,483 | +100.0% | 1.57% | – |
| AGN | ALLERGAN PLC | $10,003,000 | -0.9% | 60,000 | 0.0% | 1.38% | -10.0% | |
| CLLS | Buy | CELLECTIS S Asponsored ads | $9,955,000 | -6.9% | 351,874 | +3.7% | 1.37% | -15.5% |
| RTRX | Buy | RETROPHIN INC | $9,625,000 | +95.7% | 353,072 | +60.5% | 1.33% | +77.6% |
| ARQL | Sell | ARQULE INC | $8,282,000 | +27.0% | 1,497,683 | -33.9% | 1.14% | +15.4% |
| INNT | INNOVATE BIOPHARMACEUTICLS I | $7,844,000 | -36.0% | 980,502 | 0.0% | 1.08% | -41.9% | |
| VKTX | Sell | VIKING THERAPEUTICS INC | $7,425,000 | +6.7% | 782,424 | -50.9% | 1.02% | -3.1% |
| MSFT | Buy | MICROSOFT CORP | $7,340,000 | +20.3% | 74,435 | +11.3% | 1.01% | +9.3% |
| IMMU | Sell | IMMUNOMEDICS INC | $7,259,000 | +3.5% | 306,655 | -36.1% | 1.00% | -6.0% |
| MLNX | Sell | MELLANOX TECHNOLOGIES LTD | $7,246,000 | -0.8% | 85,954 | -14.3% | 1.00% | -9.9% |
| NERV | Buy | MINERVA NEUROSCIENCES INC | $6,766,000 | +39.7% | 820,120 | +5.8% | 0.93% | +26.9% |
| ALDX | Sell | ALDEYRA THERAPEUTICS INC | $6,733,000 | -11.0% | 846,935 | -16.1% | 0.93% | -19.2% |
| KURA | Buy | KURA ONCOLOGY INC | $6,406,000 | +3.5% | 351,953 | +6.7% | 0.88% | -6.0% |
| SODA | New | SODASTREAM INTERNATIONAL LTD | $6,292,000 | – | 73,762 | +100.0% | 0.87% | – |
| MLNT | Buy | MELINTA THERAPEUTICS INC | $6,252,000 | +246.4% | 984,492 | +303.7% | 0.86% | +214.6% |
| NICE | Sell | NICE LTDsponsored adr | $6,231,000 | -2.1% | 60,043 | -11.4% | 0.86% | -11.1% |
| KDMN | Buy | KADMON HLDGS INC | $6,196,000 | -2.2% | 1,552,846 | +4.2% | 0.85% | -11.2% |
| QURE | Buy | UNIQURE NV | $5,764,000 | +92.2% | 152,490 | +19.5% | 0.80% | +74.7% |
| ARRY | Sell | ARRAY BIOPHARMA INC | $5,702,000 | -13.7% | 339,804 | -16.1% | 0.79% | -21.7% |
| ADMS | Sell | ADAMAS PHARMACEUTICALS INC | $5,518,000 | -31.2% | 213,625 | -36.3% | 0.76% | -37.5% |
| BHVN | Buy | BIOHAVEN PHARMACTL HLDG CO L | $5,430,000 | +60.8% | 137,388 | +4.8% | 0.75% | +46.0% |
| AGLE | New | AEGLEA BIOTHERAPEUTICS INC | $5,386,000 | – | 509,118 | +100.0% | 0.74% | – |
| V | VISA INC | $5,351,000 | +10.7% | 40,401 | 0.0% | 0.74% | +0.5% | |
| ASND | Sell | ASCENDIS PHARMA A Ssponsored adr | $5,192,000 | -16.8% | 78,048 | -18.3% | 0.72% | -24.5% |
| ZFGN | New | ZAFGEN INC | $4,910,000 | – | 480,000 | +100.0% | 0.68% | – |
| RETA | Sell | REATA PHARMACEUTICALS INCcl a | $4,757,000 | +3.1% | 136,044 | -39.5% | 0.66% | -6.4% |
| AUTL | New | AUTOLUS THERAPEUTICS PLCspon ads | $4,716,000 | – | 176,045 | +100.0% | 0.65% | – |
| SESN | New | SESEN BIO INC | $4,635,000 | – | 2,377,068 | +100.0% | 0.64% | – |
| WAB | New | WABTEC CORP | $4,590,000 | – | 46,564 | +100.0% | 0.63% | – |
| ARPO | New | AERPIO PHARMACEUTICALS INC | $4,580,000 | – | 1,103,554 | +100.0% | 0.63% | – |
| LPTX | Buy | LEAP THERAPEUTICS INC | $4,492,000 | +26.7% | 499,137 | +16.9% | 0.62% | +15.1% |
| MA | Buy | MASTERCARD INCORPORATEDcl a | $4,473,000 | +54.5% | 22,760 | +37.7% | 0.62% | +40.2% |
| SRRK | New | SCHOLAR ROCK HLDG CORP | $4,430,000 | – | 283,997 | +100.0% | 0.61% | – |
| CTIC | Buy | CTI BIOPHARMA CORP | $4,355,000 | +34.0% | 874,407 | +4.9% | 0.60% | +21.5% |
| CSCO | New | CISCO SYS INC | $4,303,000 | – | 100,000 | +100.0% | 0.59% | – |
| PIRS | Buy | PIERIS PHARMACEUTICALS INC | $4,272,000 | -21.7% | 842,632 | +5.3% | 0.59% | -28.9% |
| EPZM | New | EPIZYME INC | $4,162,000 | – | 307,154 | +100.0% | 0.57% | – |
| SBBP | New | STRONGBRIDGE BIOPHARMA PLC | $4,044,000 | – | 673,996 | +100.0% | 0.56% | – |
| XENE | New | XENON PHARMACEUTICALS INC | $4,039,000 | – | 439,034 | +100.0% | 0.56% | – |
| KZR | New | KEZAR LIFE SCIENCES INC | $3,943,000 | – | 227,900 | +100.0% | 0.54% | – |
| GLYC | Buy | GLYCOMIMETICS INC | $3,870,000 | +58.9% | 239,933 | +60.0% | 0.53% | +44.3% |
| FB | Buy | FACEBOOK INCcl a | $3,712,000 | +281.1% | 19,100 | +213.3% | 0.51% | +245.9% |
| GOOGL | Sell | ALPHABET INCcap stk cl a | $3,691,000 | -25.7% | 3,269 | -31.8% | 0.51% | -32.6% |
| CRVS | Buy | CORVUS PHARMACEUTICALS INC | $3,689,000 | -0.5% | 335,987 | +4.5% | 0.51% | -9.6% |
| OBSV | Sell | OBSEVA SA | $3,689,000 | -63.3% | 243,669 | -67.3% | 0.51% | -66.6% |
| DCPH | Buy | DECIPHERA PHARMACEUTICALS IN | $3,661,000 | +347.0% | 93,031 | +127.8% | 0.50% | +307.3% |
| FLEX | Sell | FLEX LTDord | $3,666,000 | -27.1% | 259,824 | -15.6% | 0.50% | -33.8% |
| PRQR | Sell | PROQR THRAPEUTICS N V | $3,604,000 | +78.0% | 493,749 | -25.0% | 0.50% | +61.9% |
| ABEO | Sell | ABEONA THERAPEUTICS INC | $3,571,000 | -15.6% | 223,172 | -24.3% | 0.49% | -23.5% |
| EVOK | Buy | EVOKE PHARMA INC | $3,527,000 | +330.6% | 1,410,946 | +258.2% | 0.49% | +291.9% |
| ALNA | Sell | ALLENA PHARMACEUTICALS INC | $3,484,000 | -22.9% | 267,349 | -34.8% | 0.48% | -30.0% |
| CSTE | Buy | CAESARSTONE LTD | $3,485,000 | +1352.1% | 230,816 | +1792.7% | 0.48% | +1233.3% |
| VRTX | New | VERTEX PHARMACEUTICALS INC | $3,399,000 | – | 20,000 | +100.0% | 0.47% | – |
| SRRA | Buy | SIERRA ONCOLOGY INC | $3,184,000 | +53.8% | 1,075,806 | +7.6% | 0.44% | +39.8% |
| ORLY | O REILLY AUTOMOTIVE INC NEW | $2,967,000 | +10.6% | 10,844 | 0.0% | 0.41% | +0.5% | |
| WIX | New | WIX COM LTD | $2,963,000 | – | 29,542 | +100.0% | 0.41% | – |
| FIXX | Buy | HOMOLOGY MEDICINES INC | $2,893,000 | +16.3% | 141,836 | +6.6% | 0.40% | +5.6% |
| ELOX | New | ELOXX PHARMACEUTICALS INC | $2,859,000 | – | 167,474 | +100.0% | 0.39% | – |
| FSCT | New | FORESCOUT TECHNOLOGIES INC | $2,617,000 | – | 76,400 | +100.0% | 0.36% | – |
| LRCX | Buy | LAM RESEARCH CORP | $2,523,000 | -7.0% | 14,597 | +9.3% | 0.35% | -15.5% |
| VRCA | New | VERRICA PHARMACEUTICALS INC | $2,482,000 | – | 125,800 | +100.0% | 0.34% | – |
| APTX | New | APTINYX INC | $2,477,000 | – | 102,474 | +100.0% | 0.34% | – |
| APLS | New | APELLIS PHARMACEUTICALS INC | $2,438,000 | – | 110,803 | +100.0% | 0.34% | – |
| MRVL | New | MARVELL TECHNOLOGY GROUP LTDord | $2,355,000 | – | 109,842 | +100.0% | 0.32% | – |
| SEDG | Buy | SOLAREDGE TECHNOLOGIES INC | $2,342,000 | +159.1% | 48,948 | +184.7% | 0.32% | +135.8% |
| KRNT | New | KORNIT DIGITAL LTD | $2,329,000 | – | 130,831 | +100.0% | 0.32% | – |
| NEOS | Buy | NEOS THERAPEUTICS INC | $2,201,000 | -17.3% | 352,142 | +9.8% | 0.30% | -25.0% |
| CTMX | Sell | CYTOMX THERAPEUTICS INC | $1,901,000 | -62.9% | 83,142 | -53.8% | 0.26% | -66.3% |
| VTGN | Buy | VISTAGEN THERAPEUTICS INC | $1,879,000 | +62.4% | 1,371,892 | +10.0% | 0.26% | +47.2% |
| TBIO | New | TRANSLATE BIO INC | $1,645,000 | – | 130,000 | +100.0% | 0.23% | – |
| GILT | Buy | GILAT SATELLITE NETWORKS LTD | $1,501,000 | +52.4% | 163,367 | +46.3% | 0.21% | +38.0% |
| PTLA | New | PORTOLA PHARMACEUTICALS INC | $1,385,000 | – | 120,000 | +100.0% | 0.19% | – |
| DK | Sell | DELEK US HLDGS INC NEW | $1,231,000 | -75.3% | 24,533 | -79.9% | 0.17% | -77.5% |
| ZYME | New | ZYMEWORKS INC | $1,091,000 | – | 73,800 | +100.0% | 0.15% | – |
| RDCM | Sell | RADCOM LTD | $1,042,000 | -13.7% | 52,760 | -19.8% | 0.14% | -21.3% |
| TEVA PHARMACEUTICAL FIN LLCdbcv 0.250% 2/0 | $970,000 | +38.0% | 2,135 | 0.0% | 0.13% | +25.2% | ||
| AAP | ADVANCE AUTO PARTS INC | $724,000 | +14.4% | 5,336 | 0.0% | 0.10% | +4.2% | |
| MRTX | New | MIRATI THERAPEUTICS INC | $707,000 | – | 14,335 | +100.0% | 0.10% | – |
| AQXP | Buy | AQUINOX PHARMACEUTICALS INC | $683,000 | -35.8% | 257,613 | +241.1% | 0.09% | -42.0% |
| RCKT | Sell | ROCKET PHARMACEUTICALS INC | $677,000 | -88.1% | 34,475 | -88.6% | 0.09% | -89.2% |
| TCDA | New | TRICIDA INC | $610,000 | – | 20,410 | +100.0% | 0.08% | – |
| BMRN | New | BIOMARIN PHARMACEUTICAL INC | $589,000 | – | 6,250 | +100.0% | 0.08% | – |
| SERV | SERVICEMASTER GLOBAL HLDGS I | $565,000 | +17.0% | 9,500 | 0.0% | 0.08% | +6.8% | |
| UNH | UNITEDHEALTH GROUP INC | $491,000 | +14.7% | 2,000 | 0.0% | 0.07% | +4.6% | |
| AUDC | New | AUDIOCODES LTDord | $461,000 | – | 59,226 | +100.0% | 0.06% | – |
| RDWR | Sell | RADWARE LTDord | $443,000 | +13.9% | 17,527 | -3.9% | 0.06% | +3.4% |
| CHTR | Sell | CHARTER COMMUNICATIONS INC Ncl a | $416,000 | -59.8% | 1,419 | -57.4% | 0.06% | -63.7% |
| SITE | SITEONE LANDSCAPE SUPPLY INC | $252,000 | +9.1% | 3,000 | 0.0% | 0.04% | 0.0% | |
| MHK | MOHAWK INDS INC | $236,000 | -7.5% | 1,100 | 0.0% | 0.03% | -15.4% | |
| CISN | New | CISION LTD | $224,000 | – | 15,000 | +100.0% | 0.03% | – |
| SNA | SNAP ON INC | $220,000 | +8.9% | 1,366 | 0.0% | 0.03% | -3.2% | |
| EIDX | New | EIDOS THERAPEUTICS INC | $220,000 | – | 10,828 | +100.0% | 0.03% | – |
| ULTI | ULTIMATE SOFTWARE GROUP INC | $206,000 | +5.6% | 800 | 0.0% | 0.03% | -6.7% | |
| KMPH | New | KEMPHARM INC | $147,000 | – | 22,622 | +100.0% | 0.02% | – |
| LPSN | Exit | LIVEPERSON INC | $0 | – | -136 | -100.0% | 0.00% | – |
| ATHX | Exit | ATHERSYS INC | $0 | – | -773 | -100.0% | 0.00% | – |
| VSTO | Exit | VISTA OUTDOOR INC | $0 | – | -6,000 | -100.0% | -0.02% | – |
| XRAY | Exit | DENTSPLY SIRONA INC | $0 | – | -2,500 | -100.0% | -0.02% | – |
| GLIBA | Exit | GCI LIBERTY INC | $0 | – | -3,000 | -100.0% | -0.02% | – |
| SEE | Exit | SEALED AIR CORP NEW | $0 | – | -4,500 | -100.0% | -0.03% | – |
| CMCSA | Exit | COMCAST CORP NEWcl a | $0 | – | -10,000 | -100.0% | -0.05% | – |
| WSO | Exit | WATSCO INC | $0 | – | -2,100 | -100.0% | -0.06% | – |
| VTVT | Exit | VTV THERAPEUTICS INCcl a | $0 | – | -281,679 | -100.0% | -0.17% | – |
| PRGO | Exit | PERRIGO CO PLC | $0 | – | -19,221 | -100.0% | -0.24% | – |
| FGEN | Exit | FIBROGEN INC | $0 | – | -39,779 | -100.0% | -0.28% | – |
| EXPE | Exit | EXPEDIA GROUP INC | $0 | – | -18,900 | -100.0% | -0.32% | – |
| VBIV | Exit | VBI VACCINES INC | $0 | – | -666,284 | -100.0% | -0.35% | – |
| ERYP | Exit | ERYTECH PHARMAsponsored adr | $0 | – | -120,000 | -100.0% | -0.38% | – |
| ASNS | Exit | ARSANIS INC | $0 | – | -114,972 | -100.0% | -0.40% | – |
| BOLD | Exit | AUDENTES THERAPEUTICS INC | $0 | – | -95,000 | -100.0% | -0.43% | – |
| CHRS | Exit | COHERUS BIOSCIENCES INC | $0 | – | -270,000 | -100.0% | -0.45% | – |
| RGNX | Exit | REGENXBIO INC | $0 | – | -100,000 | -100.0% | -0.45% | – |
| CMTA | Exit | CLEMENTIA PHARMACEUTICALS IN | $0 | – | -200,000 | -100.0% | -0.46% | – |
| GEMP | Exit | GEMPHIRE THERAPEUTICS INC | $0 | – | -481,046 | -100.0% | -0.48% | – |
| ENDP | Exit | ENDO INTL PLC | $0 | – | -550,000 | -100.0% | -0.50% | – |
| NTLA | Exit | INTELLIA THERAPEUTICS INC | $0 | – | -160,000 | -100.0% | -0.51% | – |
| MGNX | Exit | MACROGENICS INC | $0 | – | -135,000 | -100.0% | -0.52% | – |
| REPH | Exit | RECRO PHARMA INC | $0 | – | -364,197 | -100.0% | -0.61% | – |
| PBYI | Exit | PUMA BIOTECHNOLOGY INC | $0 | – | -60,000 | -100.0% | -0.62% | – |
| SNDX | Exit | SYNDAX PHARMACEUTICALS INC | $0 | – | -298,472 | -100.0% | -0.64% | – |
| EIGR | Exit | EIGER BIOPHARMACEUTICALS INC | $0 | – | -475,000 | -100.0% | -0.71% | – |
| TSRO | Exit | TESARO INC | $0 | – | -106,175 | -100.0% | -0.92% | – |
| MNOV | Exit | MEDICINOVA INC | $0 | – | -630,838 | -100.0% | -0.98% | – |
| PTLA | Exit | PORTOLA PHARMACEUTICALS INCcall | $0 | – | -200,000 | -100.0% | -0.99% | – |
| LJPC | Exit | LA JOLLA PHARMACEUTICAL CO | $0 | – | -260,000 | -100.0% | -1.18% | – |
| CLVS | Exit | CLOVIS ONCOLOGY INC | $0 | – | -168,000 | -100.0% | -1.35% | – |
| QQQ | Exit | POWERSHARES QQQ TRUSTput | $0 | – | -80,000 | -100.0% | -1.94% | – |
| REGN | Exit | REGENERON PHARMACEUTICALS | $0 | – | -41,500 | -100.0% | -2.17% | – |
| CELG | Exit | CELGENE CORP | $0 | – | -319,000 | -100.0% | -4.32% | – |
| XBI | Exit | SPDR SERIES TRUSTput | $0 | – | -750,000 | -100.0% | -9.99% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2018-08-13
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| TEVA PHARMACEUTICAL-SP ADR | 36 | Q3 2023 | 8.4% |
| MERCK & CO INC NEW | 35 | Q3 2023 | 8.4% |
| NICE Systems Ltd | 27 | Q3 2023 | 4.4% |
| BIOGEN INC | 26 | Q3 2023 | 6.7% |
| AMICUS THERAPEUTICS INC | 26 | Q2 2022 | 4.3% |
| PFIZER INC | 25 | Q3 2023 | 9.2% |
| SAREPTA THERAPEUTICS INC | 25 | Q3 2023 | 3.2% |
| JOHNSON & JOHNSON | 24 | Q3 2023 | 8.0% |
| UNIQURE NV | 23 | Q3 2023 | 1.2% |
| SYNDAX PHARMACEUTICALS INC | 22 | Q3 2023 | 3.9% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Cyclacel Pharmaceuticals, Inc. | February 06, 2023 | 250,000 | 2.0% |
| Altimmune, Inc. | February 14, 2022 | 1,244,241 | 3.1% |
| Allot Ltd. | February 16, 2021 | 1,129,054 | 3.2% |
| Larimar Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Neos Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Orgenesis Inc. | February 16, 2021 | 525,216 | 0.0% |
| Sio Gene Therapies Inc. | February 16, 2021 | ? | ? |
| X4 Pharmaceuticals, Inc | February 16, 2021 | 250,000 | 0.0% |
| Axovant Gene Therapies Ltd. | February 25, 2020 | 2,931,017 | 8.0% |
| Axovant Gene Therapies Ltd. | February 11, 2020 | 398,540 | 1.8% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 13F-HR/A | 2024-02-15 |
| 13F-HR | 2024-02-14 |
| SC 13G | 2024-02-08 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| 13F-HR | 2023-11-14 |
| SC 13G | 2023-10-10 |
| SC 13G | 2023-08-30 |
View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.