$406 Million is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 104 reported holdings in Q2 2014. The portfolio turnover from Q1 2014 to Q2 2014 was 83.8% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| NVS | Sell | Novartis AGsponsored adr | $48,272,000 | +6.2% | 533,100 | -0.4% | 11.90% | +14.7% |
| MRK | Sell | Merck & Co Inc | $24,876,000 | -17.3% | 430,000 | -18.9% | 6.13% | -10.7% |
| TEVA | Buy | Teva Pharmaceutical Industriesadr | $23,301,000 | +615.9% | 444,500 | +621.6% | 5.74% | +672.8% |
| JNJ | Sell | Johnson & Johnson | $22,347,000 | +1.7% | 213,600 | -4.5% | 5.51% | +9.8% |
| PFE | Sell | Pfizer Inc | $19,428,000 | -29.2% | 654,596 | -23.4% | 4.79% | -23.6% |
| GSK | Sell | GlaxoSmithKline PLCsponsored adr | $16,044,000 | -53.8% | 300,000 | -53.8% | 3.95% | -50.1% |
| SHPG | New | Shire PLCsponsored adr | $14,065,000 | – | 180,000 | +100.0% | 3.47% | – |
| SNY | Sell | Sanofisponsored adr | $12,746,000 | -61.8% | 120,000 | -62.5% | 3.14% | -58.8% |
| SGEN | Buy | Seattle Genetics Inc | $11,391,000 | +95.6% | 297,800 | +133.0% | 2.81% | +111.2% |
| BMRN | New | BioMarin Pharmaceutical Inc | $7,465,000 | – | 120,000 | +100.0% | 1.84% | – |
| BIIB | Buy | Biogen Idec Inc | $6,937,000 | +33.4% | 22,000 | +29.4% | 1.71% | +44.1% |
| New | Allergan Inc/United States | $6,769,000 | – | 40,000 | +100.0% | 1.67% | – | |
| VRNT | New | Verint Systems Inc | $6,600,000 | – | 134,550 | +100.0% | 1.63% | – |
| DYAX | New | Dyax Corp | $6,240,000 | – | 650,000 | +100.0% | 1.54% | – |
| LLY | Sell | Eli Lilly & Co | $6,217,000 | -64.8% | 100,000 | -66.7% | 1.53% | -62.0% |
| AVNR | New | AVANIR Pharmaceuticals Inccl a new | $5,640,000 | – | 1,000,000 | +100.0% | 1.39% | – |
| MDVN | New | Medivation Inc | $5,396,000 | – | 70,000 | +100.0% | 1.33% | – |
| ORBK | Buy | Orbotech Ltdord | $5,216,000 | +51.8% | 343,602 | +54.0% | 1.28% | +63.9% |
| ACOR | New | Acorda Therapeutics Inc | $5,057,000 | – | 150,000 | +100.0% | 1.25% | – |
| Sell | Amgen Inc | $4,735,000 | -45.2% | 40,000 | -42.9% | 1.17% | -40.8% | |
| BCOMF | New | B Communications Ltd | $4,708,000 | – | 241,705 | +100.0% | 1.16% | – |
| YUM | New | Yum! Brands Inc | $4,582,000 | – | 56,433 | +100.0% | 1.13% | – |
| CSX | Buy | CSX Corp | $4,570,000 | +35.0% | 148,325 | +27.0% | 1.13% | +45.7% |
| WAG | Buy | Walgreen Co | $4,521,000 | +33.1% | 60,993 | +18.5% | 1.11% | +43.7% |
| PCYC | New | Pharmacyclics Inc | $4,486,000 | – | 50,000 | +100.0% | 1.11% | – |
| TW | New | Towers Watson & Cocl a | $4,351,000 | – | 41,740 | +100.0% | 1.07% | – |
| CLVS | Buy | Clovis Oncology Inc | $4,348,000 | +56.9% | 105,000 | +162.5% | 1.07% | +69.4% |
| GILD | Sell | Gilead Sciences Inc | $4,146,000 | -37.8% | 50,000 | -46.8% | 1.02% | -32.8% |
| INCY | Sell | Incyte Corp Ltd | $4,120,000 | -7.2% | 73,000 | -12.0% | 1.02% | +0.1% |
| PTCT | New | PTC Therapeutics Inc | $3,921,000 | – | 150,000 | +100.0% | 0.97% | – |
| EPZM | New | Epizyme Inc | $3,522,000 | – | 113,188 | +100.0% | 0.87% | – |
| CL | Sell | Colgate-Palmolive Co | $3,259,000 | -20.0% | 47,799 | -23.9% | 0.80% | -13.7% |
| AN | New | AutoNation Inc | $3,139,000 | – | 52,600 | +100.0% | 0.77% | – |
| BRCM | Sell | Broadcom Corpcl a | $2,937,000 | -17.1% | 79,120 | -29.7% | 0.72% | -10.5% |
| CSTE | Buy | Caesarstone Sdot-Yam Ltd | $2,925,000 | +586.6% | 59,600 | +661.2% | 0.72% | +643.3% |
| AERI | Sell | Aerie Pharmaceuticals Inc | $2,725,000 | +14.3% | 110,000 | -2.2% | 0.67% | +23.5% |
| TTPH | New | Tetraphase Pharmaceuticals Inc | $2,671,000 | – | 198,000 | +100.0% | 0.66% | – |
| GOOG | New | Google Inccl c | $2,612,000 | – | 4,540 | +100.0% | 0.64% | – |
| AMPE | Buy | Ampio Pharmaceuticals Inc | $2,605,000 | +82.3% | 312,000 | +38.7% | 0.64% | +96.9% |
| RCPT | New | Receptos Inc | $2,556,000 | – | 60,000 | +100.0% | 0.63% | – |
| MGNX | Buy | MacroGenics Inc | $2,412,000 | +111.4% | 111,000 | +170.7% | 0.59% | +128.5% |
| CLDN | New | Celladon Corp | $2,403,000 | – | 150,000 | +100.0% | 0.59% | – |
| ONTY | Oncothyreon Inc | $2,392,000 | +8.3% | 738,336 | 0.0% | 0.59% | +16.9% | |
| PCLN | Sell | priceline.com Inc | $2,324,000 | -13.0% | 1,932 | -13.8% | 0.57% | -6.1% |
| VNDA | Buy | Vanda Pharmaceuticals Inc | $2,265,000 | +114.5% | 140,000 | +115.4% | 0.56% | +131.5% |
| GOOGL | Buy | Google Inccl a | $2,212,000 | -30.7% | 3,784 | +32.1% | 0.54% | -25.2% |
| ATNM | New | Actinium Pharmaceuticals Inc | $2,166,000 | – | 300,000 | +100.0% | 0.53% | – |
| AKBA | New | Akebia Therapeutics Inc | $2,015,000 | – | 72,500 | +100.0% | 0.50% | – |
| IMMU | Buy | Immunomedics Inc | $2,008,000 | +59.0% | 550,000 | +83.3% | 0.50% | +71.9% |
| Gilead Sciences Inccall | $2,008,000 | +76.1% | 2,000 | 0.0% | 0.50% | +90.4% | ||
| TRVN | Buy | Trevena Inc | $1,927,000 | -1.9% | 341,000 | +36.4% | 0.48% | +5.8% |
| AMBI | Buy | Ambit Biosciences Corp | $1,918,000 | +41.7% | 277,568 | +87.0% | 0.47% | +53.1% |
| Buy | Vertex Pharmaceuticals Inccall | $1,905,000 | +250.8% | 1,000 | +100.0% | 0.47% | +278.2% | |
| RXDX | Ignyta Inc | $1,863,000 | +9.5% | 205,000 | 0.0% | 0.46% | +18.0% | |
| XLV | Sell | Health Care Select Sector SPDRsbi healthcare | $1,786,000 | -80.8% | 29,353 | -81.6% | 0.44% | -79.3% |
| AQXP | Aquinox Pharmaceuticals Inc | $1,780,000 | -26.4% | 190,000 | 0.0% | 0.44% | -20.5% | |
| OMED | New | OncoMed Pharmaceuticals Inc | $1,748,000 | – | 75,000 | +100.0% | 0.43% | – |
| CYTR | Sell | CytRx Corp | $1,672,000 | +18.3% | 400,000 | -1.2% | 0.41% | +27.6% |
| GLMD | Galmed Pharmaceuticals Ltd | $1,656,000 | -15.1% | 170,000 | 0.0% | 0.41% | -8.3% | |
| PBYI | New | Puma Biotechnology Inc | $1,650,000 | – | 25,000 | +100.0% | 0.41% | – |
| P103PS | Sell | NPS Pharmaceuticals Inc | $1,619,000 | -30.7% | 49,000 | -37.2% | 0.40% | -25.1% |
| ITCI | Sell | Intra-Cellular Therapies Inc | $1,590,000 | -12.5% | 94,300 | -5.7% | 0.39% | -5.5% |
| INSM | Buy | Insmed Inc | $1,586,000 | +19.0% | 79,400 | +13.4% | 0.39% | +28.6% |
| RNA | New | Prosensa Holding BV | $1,578,000 | – | 125,000 | +100.0% | 0.39% | – |
| GNVC | GenVec Inc | $1,478,000 | -3.0% | 575,000 | 0.0% | 0.36% | +4.6% | |
| CVS | Sell | CVS Caremark Corp | $1,454,000 | -45.7% | 19,295 | -46.1% | 0.36% | -41.5% |
| PAG | New | Penske Automotive Group Inc | $1,452,000 | – | 29,327 | +100.0% | 0.36% | – |
| New | Arrowhead Research Corp | $1,431,000 | – | 100,000 | +100.0% | 0.35% | – | |
| TJX | Sell | TJX Cos Inc | $1,377,000 | -69.7% | 25,916 | -65.4% | 0.34% | -67.3% |
| SAH | New | Sonic Automotive Inccl a | $1,334,000 | – | 50,000 | +100.0% | 0.33% | – |
| ARRY | New | Array BioPharma Inc | $1,300,000 | – | 285,000 | +100.0% | 0.32% | – |
| BLRX | BioLine RX Ltdsponsored adr | $1,248,000 | -6.7% | 600,000 | 0.0% | 0.31% | +1.0% | |
| Buy | Teva Pharmaceutical Industriescall | $1,240,000 | -51.0% | 3,210 | +7.0% | 0.31% | -47.1% | |
| TLOG | TetraLogic Pharmaceuticals Cor | $1,178,000 | -7.7% | 200,000 | 0.0% | 0.29% | -0.3% | |
| AGIO | New | Agios Pharmaceuticals Inc | $1,146,000 | – | 25,000 | +100.0% | 0.28% | – |
| ACHN | New | Achillion Pharmaceuticals Inc | $1,136,000 | – | 150,000 | +100.0% | 0.28% | – |
| New | Amgen Inccall | $1,120,000 | – | 1,238 | +100.0% | 0.28% | – | |
| STEM | New | StemCells Inc | $1,015,000 | – | 500,000 | +100.0% | 0.25% | – |
| OCRX | Buy | Ocera Therapeutics Inc | $971,000 | -24.0% | 127,048 | +4.9% | 0.24% | -18.2% |
| DPRX | Sell | Dipexium Pharmaceuticals Inc | $916,000 | -27.0% | 94,400 | -24.5% | 0.23% | -21.0% |
| New | SALIX PHARMACEUTICALS LTcall | $915,000 | – | 500 | +100.0% | 0.22% | – | |
| DSCO | Discovery Laboratories Inc | $890,000 | -17.2% | 500,000 | 0.0% | 0.22% | -10.6% | |
| KBIO | KaloBios Pharmaceuticals Inc | $821,000 | -15.9% | 360,000 | 0.0% | 0.20% | -9.4% | |
| GlaxoSmithKline PLCcall | $698,000 | -20.5% | 3,000 | 0.0% | 0.17% | -14.0% | ||
| ORA | Ormat Technologies Inc | $677,000 | -3.8% | 23,472 | 0.0% | 0.17% | +3.7% | |
| TGTX | Sell | TG Therapeutics Inc | $563,000 | -59.2% | 60,000 | -70.0% | 0.14% | -55.9% |
| Impax Laboratories Inccall | $550,000 | +64.2% | 1,000 | 0.0% | 0.14% | +78.9% | ||
| CORI | New | Corium International Inc | $537,000 | – | 69,100 | +100.0% | 0.13% | – |
| RXII | New | RXi Pharmaceuticals Corp | $531,000 | – | 175,815 | +100.0% | 0.13% | – |
| SMMF | Sell | Summit Corp PLC | $455,000 | -74.0% | 777 | -100.0% | 0.11% | -72.0% |
| New | SPDR S&P 500 ETF Trustcall | $338,000 | – | 1,500 | +100.0% | 0.08% | – | |
| CYTK | Sell | Cytokinetics Inc | $311,000 | -74.8% | 65,100 | -49.9% | 0.08% | -72.7% |
| Insmed Inccall | $293,000 | -17.5% | 1,000 | 0.0% | 0.07% | -11.1% | ||
| ELLO | Sell | Ellomay Capital Ltd | $192,000 | -80.7% | 20,564 | -79.6% | 0.05% | -79.3% |
| New | Teva Pharmaceutical Industriesput | $80,000 | – | 1,000 | +100.0% | 0.02% | – | |
| TISA | New | TOP Image Systems Ltdord | $79,000 | – | 20,000 | +100.0% | 0.02% | – |
| New | TJX Cos Inccall | $69,000 | – | 500 | +100.0% | 0.02% | – | |
| Auxilium Pharmaceuticals Inccall | $40,000 | -88.0% | 935 | 0.0% | 0.01% | -86.8% | ||
| New | Vertex Pharmaceuticals Incput | $13,000 | – | 1,500 | +100.0% | 0.00% | – | |
| LMNS | New | Lumenis Ltd | $0 | – | 245 | +100.0% | 0.00% | – |
| Exit | Cytokinetics Inccall | $0 | – | -131 | -100.0% | -0.00% | – | |
| Exit | Pfizer Inccall | $0 | – | -2,000 | -100.0% | -0.02% | – | |
| Exit | Corcept Therapeutics Inccall | $0 | – | -1,206 | -100.0% | -0.03% | – | |
| VICL | Exit | Vical Inc | $0 | – | -300,000 | -100.0% | -0.09% | – |
| IMGN | Exit | Immunogen Inc | $0 | – | -34,500 | -100.0% | -0.12% | – |
| CNAT | Exit | Conatus Pharmaceuticals Inc | $0 | – | -80,000 | -100.0% | -0.15% | – |
| FFIV | Exit | F5 NETWORKS INC | $0 | – | -6,222 | -100.0% | -0.15% | – |
| XLRN | Exit | Acceleron Pharma Inc | $0 | – | -20,000 | -100.0% | -0.16% | – |
| Exit | Ishares Russell 2000 Indexput | $0 | – | -3,000 | -100.0% | -0.16% | – | |
| Exit | COMPUGEN LTDord | $0 | – | -69,109 | -100.0% | -0.17% | – | |
| BIOD | Exit | Biodel Inc | $0 | – | -283,900 | -100.0% | -0.18% | – |
| TNXP | Exit | Tonix Pharmaceuticals Holding | $0 | – | -100,000 | -100.0% | -0.24% | – |
| SRCL | Exit | STERICYCLE INC | $0 | – | -9,439 | -100.0% | -0.24% | – |
| QLTI | Exit | QLT Inc | $0 | – | -200,000 | -100.0% | -0.25% | – |
| XNCR | Exit | Xencor Inc | $0 | – | -100,000 | -100.0% | -0.27% | – |
| OMER | Exit | Omeros Corp | $0 | – | -100,000 | -100.0% | -0.28% | – |
| NKTR | Exit | Nektar Therapeutics | $0 | – | -100,000 | -100.0% | -0.28% | – |
| PPHM | Exit | Peregrine Pharmaceuticals Inc | $0 | – | -640,000 | -100.0% | -0.28% | – |
| GALTW | Exit | Galectin Therapeutics Inc*w exp 03/28/201 | $0 | – | -80,000 | -100.0% | -0.28% | – |
| CRIS | Exit | Curis Inc | $0 | – | -438,800 | -100.0% | -0.28% | – |
| ADS | Exit | ALLIANCE DATA SYSTEMS CORP | $0 | – | -4,596 | -100.0% | -0.29% | – |
| BLUE | Exit | Bluebird Bio Inc | $0 | – | -57,435 | -100.0% | -0.30% | – |
| CTIC | Exit | Cell Therapeutics Inc | $0 | – | -400,000 | -100.0% | -0.31% | – |
| IRWD | Exit | Ironwood Pharmaceuticals Inc | $0 | – | -112,484 | -100.0% | -0.32% | – |
| RLYP | Exit | Relypsa Inc | $0 | – | -47,300 | -100.0% | -0.32% | – |
| VRTX | Exit | Vertex Pharmaceuticals Inc | $0 | – | -20,000 | -100.0% | -0.32% | – |
| QURE | Exit | uniQure B.V. | $0 | – | -100,000 | -100.0% | -0.36% | – |
| Exit | Medivation Incnote 2.625% 4/0 | $0 | – | -25,000 | -100.0% | -0.37% | – | |
| FLXN | Exit | Flexion Therapeutics Inc | $0 | – | -103,955 | -100.0% | -0.39% | – |
| COST | Exit | COSTCO WHOLESALE CORP | $0 | – | -15,409 | -100.0% | -0.39% | – |
| GLYC | Exit | GlycoMimetics Inc | $0 | – | -106,000 | -100.0% | -0.40% | – |
| NCR | Exit | NCR CORPORATION | $0 | – | -47,840 | -100.0% | -0.40% | – |
| FPRX | Exit | FivePrime Therapeutics Inc | $0 | – | -90,000 | -100.0% | -0.40% | – |
| CHKP | Exit | CHECK POINT SOFTWARE TECHord | $0 | – | -26,513 | -100.0% | -0.41% | – |
| SCHW | Exit | SCHWAB (CHARLES) CORP | $0 | – | -69,200 | -100.0% | -0.43% | – |
| SILC | Exit | SILICOM LTDord | $0 | – | -32,088 | -100.0% | -0.46% | – |
| NVMI | Exit | NOVA MEASURING INSTRUMENTS US | $0 | – | -181,184 | -100.0% | -0.46% | – |
| PRTA | Exit | Prothena Corp PLC | $0 | – | -55,000 | -100.0% | -0.48% | – |
| RNN | Exit | Rexahn Pharmaceuticals Inc | $0 | – | -2,006,200 | -100.0% | -0.50% | – |
| LVS | Exit | LAS VEGAS SANDS CORP | $0 | – | -27,847 | -100.0% | -0.51% | – |
| Exit | BioMarin Pharmaceutical Incnote 1.875% 4/2 | $0 | – | -35,000 | -100.0% | -0.54% | – | |
| RDHL | Exit | Redhill Biopharma Ltdsponsored ads | $0 | – | -1,714,880 | -100.0% | -0.55% | – |
| RGDO | Exit | Regado Biosciences Inc | $0 | – | -200,000 | -100.0% | -0.57% | – |
| XLI | Exit | INDUSTRIAL SELECT SECT SPDR HEDGEFUNDsbi int-inds | $0 | – | -54,623 | -100.0% | -0.65% | – |
| PCP | Exit | PRECISION CASTPARTS CORP | $0 | – | -12,520 | -100.0% | -0.72% | – |
| FEZ | Exit | SPDR EURO STOXX 50 ETF HEDGEFUNDeuro stoxx 50 | $0 | – | -83,000 | -100.0% | -0.81% | – |
| XLE | Exit | ENERGY SELECT SECTOR SPDR HEDGEFUNDsbi int-energy | $0 | – | -40,000 | -100.0% | -0.81% | – |
| Exit | SPDR S&P Biotech ETFput | $0 | – | -2,800 | -100.0% | -0.83% | – | |
| NKE | Exit | NIKE INC -CL Bcl b | $0 | – | -49,544 | -100.0% | -0.84% | – |
| UTHR | Exit | United Therapeutics Corp | $0 | – | -50,000 | -100.0% | -1.07% | – |
| PRGO | Exit | PERRIGO CO | $0 | – | -36,106 | -100.0% | -1.28% | – |
| XLF | Exit | FINANCIAL SELECT SECTOR SPDR HEDGEFUNDsbi int-finl | $0 | – | -680,659 | -100.0% | -3.47% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR/A filed 2014-08-20
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| TEVA PHARMACEUTICAL-SP ADR | 36 | Q3 2023 | 8.4% |
| MERCK & CO INC NEW | 35 | Q3 2023 | 8.4% |
| NICE Systems Ltd | 27 | Q3 2023 | 4.4% |
| BIOGEN INC | 26 | Q3 2023 | 6.7% |
| AMICUS THERAPEUTICS INC | 26 | Q2 2022 | 4.3% |
| PFIZER INC | 25 | Q3 2023 | 9.2% |
| SAREPTA THERAPEUTICS INC | 25 | Q3 2023 | 3.2% |
| JOHNSON & JOHNSON | 24 | Q3 2023 | 8.0% |
| UNIQURE NV | 23 | Q3 2023 | 1.2% |
| SYNDAX PHARMACEUTICALS INC | 22 | Q3 2023 | 3.9% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Cyclacel Pharmaceuticals, Inc. | February 06, 2023 | 250,000 | 2.0% |
| Altimmune, Inc. | February 14, 2022 | 1,244,241 | 3.1% |
| Allot Ltd. | February 16, 2021 | 1,129,054 | 3.2% |
| Larimar Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Neos Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Orgenesis Inc. | February 16, 2021 | 525,216 | 0.0% |
| Sio Gene Therapies Inc. | February 16, 2021 | ? | ? |
| X4 Pharmaceuticals, Inc | February 16, 2021 | 250,000 | 0.0% |
| Axovant Gene Therapies Ltd. | February 25, 2020 | 2,931,017 | 8.0% |
| Axovant Gene Therapies Ltd. | February 11, 2020 | 398,540 | 1.8% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 13F-HR/A | 2024-02-15 |
| 13F-HR | 2024-02-14 |
| SC 13G | 2024-02-08 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| 13F-HR | 2023-11-14 |
| SC 13G | 2023-10-10 |
| SC 13G | 2023-08-30 |
View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.