SPHERA FUNDS MANAGEMENT LTD. - Q1 2014 holdings

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$438 Million is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 114 reported holdings in Q1 2014. The portfolio turnover from Q4 2013 to Q1 2014 was 103.1% .

All

			Value		Shares		↓ Weighting
NVS	Buy	Novartis AGsponsored adr	$45,435,000	+1784.5%	535,100	+1683.7%	10.37%	+1443.5%
GSK	Buy	GlaxoSmithKline PLCsponsored adr	$34,730,000	+18.3%	650,000	+18.2%	7.93%	-3.1%
SNY	New	Sanofisponsored adr	$33,378,000	–	320,000	+100.0%	7.62%	–
MRK	Buy	Merck & Co Inc	$30,088,000	+114.7%	530,000	+89.3%	6.87%	+75.9%
PFE	Buy	Pfizer Inc	$27,450,000	+27.6%	854,596	+21.7%	6.27%	+4.6%
JNJ	Buy	Johnson & Johnson	$21,964,000	+2976.2%	223,600	+2766.7%	5.01%	+2419.6%
LLY	New	Eli Lilly & Co	$17,658,000	–	300,000	+100.0%	4.03%	–
XLF	Sell	FINANCIAL SELECT SECTOR SPDR HEDGEFUNDsbi int-finl	$15,206,000	-8.8%	680,659	-10.8%	3.47%	-25.3%
XLV	Buy	HEALTH CARE SELECT SECTOR HEDGEFUNDsbi healthcare	$9,321,000	+23.6%	159,353	+17.2%	2.13%	+1.3%
		Amgen Inc	$8,634,000	+8.0%	70,000	0.0%	1.97%	-11.5%
GILD		Gilead Sciences Inc	$6,661,000	-5.7%	94,000	0.0%	1.52%	-22.7%
SGEN	Buy	Seattle Genetics Inc	$5,823,000	+18.9%	127,800	+4.1%	1.33%	-2.6%
PRGO	New	PERRIGO CO	$5,584,000	–	36,106	+100.0%	1.28%	–
BIIB	Buy	Biogen Idec Inc	$5,200,000	+54.9%	17,000	+41.7%	1.19%	+27.0%
UTHR	New	United Therapeutics Corp	$4,702,000	–	50,000	+100.0%	1.07%	–
TJX	Buy	TJX COMPANIES INC	$4,544,000	+9.3%	74,916	+14.9%	1.04%	-10.4%
INCY	Sell	Incyte Corp Ltd	$4,442,000	-32.5%	83,000	-36.2%	1.01%	-44.7%
CL	Buy	COLGATE-PALMOLIVE CO	$4,074,000	+17.2%	62,799	+17.8%	0.93%	-3.9%
NKE	Buy	NIKE INC -CL Bcl b	$3,659,000	+210.3%	49,544	+230.4%	0.84%	+154.6%
	New	SPDR S&P Biotech ETFput	$3,620,000	–	2,800	+100.0%	0.83%	–
XLE	New	ENERGY SELECT SECTOR SPDR HEDGEFUNDsbi int-energy	$3,562,000	–	40,000	+100.0%	0.81%	–
BRCM	Buy	BROADCOM CORP-CL Acl a	$3,542,000	+24.5%	112,500	+17.2%	0.81%	+2.0%
FEZ	New	SPDR EURO STOXX 50 ETF HEDGEFUNDeuro stoxx 50	$3,541,000	–	83,000	+100.0%	0.81%	–
ORBK	Buy	ORBOTECH LTDord	$3,435,000	+22.9%	223,174	+7.9%	0.78%	+0.6%
WAG	Buy	WALGREEN CO	$3,397,000	+67.5%	51,453	+45.8%	0.78%	+37.2%
CSX	Buy	CSX CORP	$3,384,000	+60.4%	116,825	+59.3%	0.77%	+31.5%
TEVA	Sell	Teva Pharmaceutical Industriesadr	$3,255,000	-45.9%	61,600	-58.9%	0.74%	-55.6%
GOOGL	New	GOOGLE INC-CL Acl a	$3,192,000	–	2,864	+100.0%	0.73%	–
PCP	Buy	PRECISION CASTPARTS CORP	$3,165,000	+11.7%	12,520	+19.0%	0.72%	-8.4%
XLI	Sell	INDUSTRIAL SELECT SECT SPDR HEDGEFUNDsbi int-inds	$2,858,000	-42.2%	54,623	-42.3%	0.65%	-52.7%
CLVS	Sell	Clovis Oncology Inc	$2,771,000	+2.2%	40,000	-11.1%	0.63%	-16.2%
CVS	New	CVS CAREMARK CORP	$2,680,000	–	35,795	+100.0%	0.61%	–
PCLN	Buy	PRICELINE.COM INC	$2,672,000	+16.4%	2,242	+13.5%	0.61%	-4.7%
	Sell	Teva Pharmaceutical Industriescall	$2,531,000	-36.9%	3,000	-97.0%	0.58%	-48.2%
RGDO	New	Regado Biosciences Inc	$2,504,000	–	200,000	+100.0%	0.57%	–
RDHL	New	Redhill Biopharma Ltdsponsored ads	$2,428,000	–	1,714,880	+100.0%	0.55%	–
AQXP	New	Aquinox Pharmaceuticals Inc	$2,419,000	–	190,000	+100.0%	0.55%	–
	New	BioMarin Pharmaceutical Incnote 1.875% 4/2	$2,387,000	–	35,000	+100.0%	0.54%	–
AERI	Buy	Aerie Pharmaceuticals Inc	$2,384,000	+20.6%	112,500	+2.3%	0.54%	-1.1%
P103PS	Sell	NPS Pharmaceuticals Inc	$2,335,000	-39.9%	78,000	-39.1%	0.53%	-50.7%
LVS	Buy	LAS VEGAS SANDS CORP	$2,249,000	+15.6%	27,847	+12.8%	0.51%	-5.4%
ONTY	Sell	Oncothyreon Inc	$2,208,000	+67.7%	738,336	-1.3%	0.50%	+37.3%
RNN	Buy	Rexahn Pharmaceuticals Inc	$2,167,000	+183.3%	2,006,200	+33.7%	0.50%	+132.4%
PRTA	Buy	Prothena Corp PLC	$2,107,000	+58.9%	55,000	+10.0%	0.48%	+30.4%
NVMI	New	NOVA MEASURING INSTRUMENTS US	$2,029,000	–	181,184	+100.0%	0.46%	–
SILC	Sell	SILICOM LTDord	$1,991,000	+15.2%	32,088	-15.2%	0.46%	-5.6%
TRVN	New	Trevena Inc	$1,965,000	–	250,000	+100.0%	0.45%	–
GLMD	New	Galmed Pharmaceuticals Ltd	$1,950,000	–	170,000	+100.0%	0.44%	–
SCHW	Sell	SCHWAB (CHARLES) CORP	$1,891,000	-25.7%	69,200	-29.3%	0.43%	-39.1%
ITCI	New	Intra-Cellular Therapies Inc	$1,818,000	–	100,000	+100.0%	0.42%	–
CHKP	Sell	CHECK POINT SOFTWARE TECHord	$1,793,000	-49.8%	26,513	-52.1%	0.41%	-58.9%
FPRX	New	FivePrime Therapeutics Inc	$1,769,000	–	90,000	+100.0%	0.40%	–
SMMF	New	Summit Corp PLC	$1,753,000	–	10,921,656	+100.0%	0.40%	–
NCR	New	NCR CORPORATION	$1,749,000	–	47,840	+100.0%	0.40%	–
GLYC	New	GlycoMimetics Inc	$1,731,000	–	106,000	+100.0%	0.40%	–
COST	Sell	COSTCO WHOLESALE CORP	$1,721,000	-48.1%	15,409	-44.7%	0.39%	-57.4%
FLXN	New	Flexion Therapeutics Inc	$1,710,000	–	103,955	+100.0%	0.39%	–
RXDX	New	Ignyta Inc	$1,702,000	–	205,000	+100.0%	0.39%	–
	New	Medivation Incnote 2.625% 4/0	$1,609,000	–	25,000	+100.0%	0.37%	–
QURE	New	uniQure B.V.	$1,555,000	–	100,000	+100.0%	0.36%	–
GNVC	New	GenVec Inc	$1,524,000	–	575,000	+100.0%	0.35%	–
AMPE	New	Ampio Pharmaceuticals Inc	$1,429,000	–	225,000	+100.0%	0.33%	–
CYTR	Buy	CytRx Corp	$1,413,000	-27.3%	405,000	+30.6%	0.32%	-40.3%
VRTX	New	Vertex Pharmaceuticals Inc	$1,414,000	–	20,000	+100.0%	0.32%	–
RLYP	Buy	Relypsa Inc	$1,410,000	+88.0%	47,300	+57.7%	0.32%	+54.1%
IRWD	Sell	Ironwood Pharmaceuticals Inc	$1,386,000	-65.4%	112,484	-67.4%	0.32%	-71.7%
TGTX	New	TG Therapeutics Inc	$1,380,000	–	200,000	+100.0%	0.32%	–
CTIC	New	Cell Therapeutics Inc	$1,360,000	–	400,000	+100.0%	0.31%	–
AMBI	Sell	Ambit Biosciences Corp	$1,354,000	-40.0%	148,468	-36.6%	0.31%	-50.8%
BLRX	New	BioLine RX Ltdsponsored adr	$1,338,000	–	600,000	+100.0%	0.30%	–
INSM	Buy	Insmed Inc	$1,333,000	+66.8%	70,000	+48.9%	0.30%	+36.3%
BLUE	Sell	Bluebird Bio Inc	$1,306,000	-32.6%	57,435	-37.9%	0.30%	-44.8%
OCRX	Buy	Ocera Therapeutics Inc	$1,278,000	+562.2%	121,148	+714.1%	0.29%	+440.7%
TLOG	Buy	TetraLogic Pharmaceuticals Cor	$1,276,000	-23.4%	200,000	+14.3%	0.29%	-37.3%
IMMU	New	Immunomedics Inc	$1,263,000	–	300,000	+100.0%	0.29%	–
DPRX	New	Dipexium Pharmaceuticals Inc	$1,255,000	–	125,000	+100.0%	0.29%	–
ADS	New	ALLIANCE DATA SYSTEMS CORP	$1,252,000	–	4,596	+100.0%	0.29%	–
CYTK	Sell	Cytokinetics Inc	$1,235,000	+13.7%	130,000	-22.2%	0.28%	-6.6%
CRIS	New	Curis Inc	$1,237,000	–	438,800	+100.0%	0.28%	–
GALTW	New	Galectin Therapeutics Inc*w exp 03/28/201	$1,225,000	–	80,000	+100.0%	0.28%	–
PPHM	New	Peregrine Pharmaceuticals Inc	$1,216,000	–	640,000	+100.0%	0.28%	–
NKTR	New	Nektar Therapeutics	$1,212,000	–	100,000	+100.0%	0.28%	–
OMER	New	Omeros Corp	$1,207,000	–	100,000	+100.0%	0.28%	–
XNCR	Sell	Xencor Inc	$1,173,000	-13.3%	100,000	-32.4%	0.27%	-28.9%
	New	Gilead Sciences Inccall	$1,140,000	–	2,000	+100.0%	0.26%	–
MGNX	New	MacroGenics Inc	$1,141,000	–	41,000	+100.0%	0.26%	–
QLTI		QLT Inc	$1,112,000	-0.2%	200,000	0.0%	0.25%	-18.1%
SRCL	Sell	STERICYCLE INC	$1,072,000	-67.2%	9,439	-66.5%	0.24%	-73.1%
DSCO		Discovery Laboratories Inc	$1,075,000	-4.4%	500,000	0.0%	0.24%	-21.7%
VNDA	Sell	Vanda Pharmaceuticals Inc	$1,056,000	-10.4%	65,000	-31.6%	0.24%	-26.5%
TNXP	New	Tonix Pharmaceuticals Holding	$1,041,000	–	100,000	+100.0%	0.24%	–
ELLO	Buy	ELLOMAY CAPITAL LTD	$995,000	+4.2%	100,853	+1.9%	0.23%	-14.7%
KBIO	Sell	KaloBios Pharmaceuticals Inc	$976,000	-42.7%	360,000	-6.5%	0.22%	-53.0%
	New	GlaxoSmithKline PLCcall	$878,000	–	3,000	+100.0%	0.20%	–
BIOD	New	Biodel Inc	$775,000	–	283,900	+100.0%	0.18%	–
	New	COMPUGEN LTDord	$726,000	–	69,109	+100.0%	0.17%	–
ORA	New	ORMAT TECHNOLOGIES INC	$704,000	–	23,472	+100.0%	0.16%	–
XLRN	Sell	Acceleron Pharma Inc	$690,000	-65.2%	20,000	-60.0%	0.16%	-71.4%
	New	Ishares Russell 2000 Indexput	$690,000	–	3,000	+100.0%	0.16%	–
FFIV	New	F5 NETWORKS INC	$663,000	–	6,222	+100.0%	0.15%	–
CNAT	Sell	Conatus Pharmaceuticals Inc	$651,000	+15.2%	80,000	-8.7%	0.15%	-5.1%
	New	Vertex Pharmaceuticals Inccall	$543,000	–	500	+100.0%	0.12%	–
IMGN	New	Immunogen Inc	$515,000	–	34,500	+100.0%	0.12%	–
CSTE	New	CAESARSTONE SDOT-YAM LTD	$426,000	–	7,830	+100.0%	0.10%	–
VICL	New	Vical Inc	$387,000	–	300,000	+100.0%	0.09%	–
	New	Insmed Inccall	$355,000	–	1,000	+100.0%	0.08%	–
	New	Impax Laboratories Inccall	$335,000	–	1,000	+100.0%	0.08%	–
	New	Auxilium Pharmaceuticals Inccall	$332,000	–	935	+100.0%	0.08%	–
	New	Corcept Therapeutics Inccall	$124,000	–	1,206	+100.0%	0.03%	–
	Sell	Pfizer Inccall	$82,000	-99.6%	2,000	-99.7%	0.02%	-99.7%
	New	Cytokinetics Inccall	$16,000	–	131	+100.0%	0.00%	–
PTX	Exit	PERNIX THERAPEUTICS HLDGS IN	$0	–	-56,500	-100.0%	-0.04%	–
	Exit	ARROWHEAD RESH CORP	$0	–	-20,000	-100.0%	-0.06%	–
GERN	Exit	GERON CORP	$0	–	-100,000	-100.0%	-0.13%	–
XNPT	Exit	XENOPORT INC	$0	–	-90,000	-100.0%	-0.14%	–
	Exit	SYNTA PHARMACEUTICALS CORPcall	$0	–	-100,000	-100.0%	-0.15%	–
	Exit	MERRIMACK PHARMACEUTICALS INcall	$0	–	-100,000	-100.0%	-0.15%	–
OGXI	Exit	ONCOGENEX PHARMACEUTICALS IN	$0	–	-74,100	-100.0%	-0.17%	–
ARQL	Exit	ARQULE INC	$0	–	-291,100	-100.0%	-0.17%	–
RIGL	Exit	RIGEL PHARMACEUTICALS INC	$0	–	-229,100	-100.0%	-0.18%	–
ENTA	Exit	ENANTA PHARMACEUTICALS INC	$0	–	-25,292	-100.0%	-0.19%	–
SPNS	Exit	SAPIENS INTL CORP N V	$0	–	-102,798	-100.0%	-0.22%	–
RNA	Exit	PROSENSA HLDG N V	$0	–	-192,428	-100.0%	-0.25%	–
THRX	Exit	THERAVANCE INC	$0	–	-28,500	-100.0%	-0.28%	–
XOMA	Exit	XOMA CORP DEL	$0	–	-160,000	-100.0%	-0.30%	–
ISIS	Exit	ISIS PHARMACEUTICALS INC	$0	–	-30,000	-100.0%	-0.33%	–
RDWR	Exit	RADWARE Ltdord	$0	–	-67,268	-100.0%	-0.34%	–
TRGT	Exit	TARGACEPT INC	$0	–	-300,000	-100.0%	-0.35%	–
PTCT	Exit	PTC THERAPEUTICS INC	$0	–	-73,583	-100.0%	-0.35%	–
CMG	Exit	Chipotle Mexican Grill Inc	$0	–	-2,450	-100.0%	-0.36%	–
ONTX	Exit	ONCONOVA THERAPEUTICS INC	$0	–	-120,000	-100.0%	-0.38%	–
INFI	Exit	INFINITY PHARMACEUTICALS INC	$0	–	-100,000	-100.0%	-0.38%	–
	Exit	ACADIA PHARMACEUTICALS INC	$0	–	-60,000	-100.0%	-0.42%	–
SRPT	Exit	SAREPTA THERAPEUTICS INC	$0	–	-80,000	-100.0%	-0.45%	–
PTLA	Exit	PORTOLA PHARMACEUTICALS INC	$0	–	-63,471	-100.0%	-0.46%	–
MDCO	Exit	MEDICINES CO	$0	–	-44,000	-100.0%	-0.47%	–
YHOO	Exit	YAHOO INC	$0	–	-44,138	-100.0%	-0.50%	–
MDVN	Exit	MEDIVATION INC	$0	–	-30,000	-100.0%	-0.53%	–
	Exit	SodaStream International Ltdput	$0	–	-40,000	-100.0%	-0.55%	–
CPRT	Exit	Copart Inc	$0	–	-57,200	-100.0%	-0.58%	–
RPRX	Exit	REPROS THERAPEUTICS INC	$0	–	-120,000	-100.0%	-0.61%	–
FL	Exit	Foot Locker Inc	$0	–	-55,119	-100.0%	-0.64%	–
	Exit	B/E Aerospace Inc	$0	–	-26,700	-100.0%	-0.65%	–
SEE	Exit	SEALED AIR CORP NEW	$0	–	-70,000	-100.0%	-0.66%	–
ITB	Exit	ISHARESmsci aust etf	$0	–	-102,000	-100.0%	-0.71%	–
	Exit	Apple Inc	$0	–	-5,520	-100.0%	-0.86%	–
	Exit	ALLERGAN INCcall	$0	–	-30,000	-100.0%	-0.93%	–
QQQ	Exit	POWERSHARES QQQ TRUSTunit ser 1	$0	–	-80,700	-100.0%	-1.98%	–
IWM	Exit	ISHARESmsci aust etf	$0	–	-67,209	-100.0%	-2.16%	–
	Exit	GILEAD SCIENCES INCput	$0	–	-120,000	-100.0%	-2.51%	–
SHPG	Exit	SHIRE PLCsponsored adr	$0	–	-65,000	-100.0%	-2.56%	–
	Exit	MERCK & CO INC NEWcall	$0	–	-200,000	-100.0%	-2.79%	–
	Exit	JOHNSON & JOHNSONcall	$0	–	-350,000	-100.0%	-8.93%	–

Other managers

Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):

Original filings

The following EDGAR filing(s) were analyzed to create this report:

View 13F-HR filed 2014-05-14

Signatures

The EDGAR filing(s) were signed by:

Israel Mor — Partner

Top long-term holdings

Name	Quarters owned	Latest quarter owned	Max weighting
TEVA PHARMACEUTICAL-SP ADR	36	Q3 2023	8.4%
MERCK & CO INC NEW	35	Q3 2023	8.4%
NICE Systems Ltd	27	Q3 2023	4.4%
BIOGEN INC	26	Q3 2023	6.7%
AMICUS THERAPEUTICS INC	26	Q2 2022	4.3%
PFIZER INC	25	Q3 2023	9.2%
SAREPTA THERAPEUTICS INC	25	Q3 2023	3.2%
JOHNSON & JOHNSON	24	Q3 2023	8.0%
UNIQURE NV	23	Q3 2023	1.2%
SYNDAX PHARMACEUTICALS INC	22	Q3 2023	3.9%

View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.

Latest significant ownerships (13-D/G)

SPHERA FUNDS MANAGEMENT LTD. Q1 2014 significant holdings filed using form 13D/G when ownership exceeds 5% of a company's total stock issue.
	Filed	Shares	Percentage
Cyclacel Pharmaceuticals, Inc.	February 06, 2023	250,000	2.0%
Altimmune, Inc.	February 14, 2022	1,244,241	3.1%
Allot Ltd.	February 16, 2021	1,129,054	3.2%
Larimar Therapeutics, Inc.	February 16, 2021	?	?
Neos Therapeutics, Inc.	February 16, 2021	?	?
Orgenesis Inc.	February 16, 2021	525,216	0.0%
Sio Gene Therapies Inc.	February 16, 2021	?	?
X4 Pharmaceuticals, Inc	February 16, 2021	250,000	0.0%
Axovant Gene Therapies Ltd.	February 25, 2020	2,931,017	8.0%
Axovant Gene Therapies Ltd.	February 11, 2020	398,540	1.8%

View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.

Latest filings

Type	Filed
13F-HR/A	2024-02-15
13F-HR	2024-02-14
SC 13G	2024-02-08
SC 13G/A	2024-02-05
SC 13G/A	2024-02-05
SC 13G/A	2024-02-05
SC 13G/A	2024-02-05
13F-HR	2023-11-14
SC 13G	2023-10-10
SC 13G	2023-08-30

View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.

All filings

View complete filings history.

Compare quarters

Issues

The following issues were detected while analyzing the report:

The reported total value is incorrect (438056000.0 != 438058000.0)

Export SPHERA FUNDS MANAGEMENT LTD.'s holdings