$4.9 Billion is the total value of RTW INVESTMENTS, LP's 77 reported holdings in Q4 2022. The portfolio turnover from Q3 2022 to Q4 2022 was 12.8% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| ALNY | ALNYLAM PHARMACEUTICALS INC | $400,050,979 | +18.7% | 1,683,362 | 0.0% | 8.17% | +5.1% | |
| RXDX | Buy | PROMETHEUS BIOSCIENCES INC | $368,973,330 | +96.0% | 3,354,303 | +5.2% | 7.53% | +73.6% |
| RCKT | Buy | ROCKET PHARMACEUTICALS INC | $346,149,698 | +37.2% | 17,687,772 | +11.9% | 7.07% | +21.5% |
| IMCR | Buy | IMMUNOCORE HLDGS PLCads | $317,270,507 | +51.8% | 5,559,322 | +24.9% | 6.48% | +34.5% |
| TMO | THERMO FISHER SCIENTIFIC INC | $239,825,495 | +8.6% | 435,500 | 0.0% | 4.90% | -3.8% | |
| AXSM | Buy | AXSOME THERAPEUTICS INC | $229,884,577 | +173.7% | 2,980,482 | +58.4% | 4.69% | +142.4% |
| MASI | Buy | MASIMO CORP | $222,145,889 | +9.3% | 1,501,493 | +4.3% | 4.54% | -3.2% |
| PTCT | Sell | PTC THERAPEUTICS INC | $214,339,322 | -24.0% | 5,615,387 | -0.1% | 4.38% | -32.7% |
| RARE | Buy | ULTRAGENYX PHARMACEUTICAL IN | $183,787,172 | +88.1% | 3,966,915 | +68.1% | 3.75% | +66.5% |
| ARGX | Buy | ARGENX SEsponsored adr | $182,669,932 | +10.7% | 482,195 | +3.2% | 3.73% | -1.9% |
| MRTX | Buy | MIRATI THERAPEUTICS INC | $165,069,495 | +25.5% | 3,643,114 | +93.5% | 3.37% | +11.2% |
| ESTA | Buy | ESTABLISHMENT LABS HLDGS INC | $155,862,160 | +20.5% | 2,374,138 | +0.2% | 3.18% | +6.7% |
| PEN | PENUMBRA INC | $155,359,613 | +17.3% | 698,371 | 0.0% | 3.17% | +3.9% | |
| CLDX | CELLDEX THERAPEUTICS INC NEW | $137,463,463 | +58.6% | 3,084,215 | 0.0% | 2.81% | +40.4% | |
| RNA | Buy | AVIDITY BIOSCIENCES INC | $124,387,510 | +47.3% | 5,605,566 | +8.4% | 2.54% | +30.4% |
| CYTK | CYTOKINETICS INC | $117,949,752 | -5.4% | 2,574,198 | 0.0% | 2.41% | -16.2% | |
| ILMN | ILLUMINA INC | $114,116,625 | +6.0% | 564,375 | 0.0% | 2.33% | -6.1% | |
| NTRA | Buy | NATERA INC | $104,814,898 | +8.3% | 2,609,283 | +18.1% | 2.14% | -4.1% |
| VCEL | VERICEL CORP | $81,651,471 | +13.5% | 3,099,904 | 0.0% | 1.67% | +0.5% | |
| CUTR | Buy | CUTERA INC | $79,537,409 | -1.5% | 1,798,675 | +1.6% | 1.62% | -12.7% |
| ACAD | ACADIA PHARMACEUTICALS INC | $58,441,333 | -2.7% | 3,670,938 | 0.0% | 1.19% | -13.9% | |
| GMED | GLOBUS MED INCcl a | $55,530,565 | +24.7% | 747,685 | 0.0% | 1.13% | +10.4% | |
| AXNX | AXONICS INC | $55,337,424 | -11.2% | 884,974 | 0.0% | 1.13% | -21.4% | |
| VENTYX BIOSCIENCES INC | $50,882,801 | -6.1% | 1,551,778 | 0.0% | 1.04% | -16.8% | ||
| RGNX | REGENXBIO INC | $41,852,901 | -14.2% | 1,845,366 | 0.0% | 0.85% | -24.0% | |
| AVDL | AVADEL PHARMACEUTICALS PLCsponsored adr | $41,112,283 | +42.9% | 5,741,939 | 0.0% | 0.84% | +26.5% | |
| PTGX | Sell | PROTAGONIST THERAPEUTICS INC | $39,188,567 | +11.3% | 3,591,986 | -14.0% | 0.80% | -1.5% |
| PMVP | PMV PHARMACEUTICALS INC | $37,905,204 | -26.9% | 4,356,920 | 0.0% | 0.77% | -35.2% | |
| ACET | ADICET BIO INC | $37,918,760 | -37.1% | 4,241,472 | 0.0% | 0.77% | -44.3% | |
| TARS | Buy | TARSUS PHARMACEUTICALS INC | $37,355,513 | +7.8% | 2,548,125 | +25.9% | 0.76% | -4.5% |
| BCYC | Sell | BICYCLE THERAPEUTICS PLCsponsored ads | $37,254,175 | +25.5% | 1,258,587 | -1.4% | 0.76% | +11.1% |
| FULC | Buy | FULCRUM THERAPEUTICS INC | $36,351,071 | +12.7% | 4,993,279 | +25.3% | 0.74% | -0.1% |
| STOK | Buy | STOKE THERAPEUTICS INC | $35,729,155 | -23.8% | 3,870,981 | +6.0% | 0.73% | -32.6% |
| TXG | Buy | 10X GENOMICS INC | $31,797,252 | +74.5% | 872,592 | +36.4% | 0.65% | +54.5% |
| OYST | Buy | OYSTER PT PHARMA INC | $25,746,593 | +124.1% | 2,304,977 | +12.8% | 0.53% | +98.5% |
| OLK | OLINK HLDG ABsponsored ads | $24,921,079 | +109.1% | 981,918 | 0.0% | 0.51% | +85.1% | |
| OM | OUTSET MED INC | $23,487,215 | +62.1% | 909,652 | 0.0% | 0.48% | +43.4% | |
| GHRS | GH RESEARCH PLCordinary shares | $21,082,262 | -16.4% | 2,168,957 | 0.0% | 0.43% | -26.0% | |
| ISEE | Sell | IVERIC BIO INC | $17,583,776 | -73.0% | 821,288 | -77.3% | 0.36% | -76.1% |
| MIST | MILESTONE PHARMACEUTICALS IN | $17,087,804 | -56.9% | 4,315,102 | 0.0% | 0.35% | -61.8% | |
| CINCOR PHARMA INC | $17,079,474 | -62.6% | 1,389,705 | 0.0% | 0.35% | -66.8% | ||
| CCCC | C4 THERAPEUTICS INC | $16,634,885 | -32.7% | 2,819,472 | 0.0% | 0.34% | -40.4% | |
| ALLK | ALLAKOS INC | $13,838,270 | +37.6% | 1,643,500 | 0.0% | 0.28% | +21.6% | |
| CSTL | CASTLE BIOSCIENCES INC | $12,170,062 | -9.7% | 516,995 | 0.0% | 0.25% | -20.3% | |
| GH | Sell | GUARDANT HEALTH INC | $11,720,126 | -70.0% | 430,887 | -40.6% | 0.24% | -73.5% |
| TERN | New | TERNS PHARMACEUTICALS INC | $10,180,000 | – | 1,000,000 | +100.0% | 0.21% | – |
| HSAQ | HEALTH SCIENCES ACQ CORP 2 | $9,980,000 | +0.8% | 1,000,000 | 0.0% | 0.20% | -10.5% | |
| AADI BIOSCIENCE INC | $9,811,114 | -9.2% | 764,701 | 0.0% | 0.20% | -19.7% | ||
| GLUE | MONTE ROSA THERAPEUTICS INC | $9,242,893 | -6.9% | 1,214,572 | 0.0% | 0.19% | -17.5% | |
| SIGHT SCIENCES INC | $8,123,594 | +92.3% | 665,323 | 0.0% | 0.17% | +71.1% | ||
| APYX | APYX MEDICAL CORPORATION | $7,951,973 | -47.9% | 3,398,279 | 0.0% | 0.16% | -54.0% | |
| URGN | UROGEN PHARMA LTD | $7,605,706 | +6.6% | 857,464 | 0.0% | 0.16% | -5.5% | |
| IMTX | Buy | IMMATICS N.V | $7,359,950 | +110.3% | 845,000 | +141.4% | 0.15% | +85.2% |
| RLMD | Sell | RELMADA THERAPEUTICS INC | $7,216,706 | -92.6% | 2,067,824 | -21.8% | 0.15% | -93.5% |
| ROIVANT SCIENCES LTD | $6,413,709 | +148.1% | 802,717 | 0.0% | 0.13% | +118.3% | ||
| JNCE | JOUNCE THERAPEUTICS INC | $5,668,039 | -52.6% | 5,106,341 | 0.0% | 0.12% | -57.8% | |
| IMUX | Buy | IMMUNIC INC | $5,405,806 | -38.1% | 3,861,290 | +39.8% | 0.11% | -45.3% |
| MOONLAKE IMMUNOTHERAPEUTICSclass a ord | $5,250,000 | +35.3% | 500,000 | 0.0% | 0.11% | +20.2% | ||
| ARYD | ARYA SCIENCES ACQU CORP IVcl a | $5,050,000 | +1.9% | 500,000 | 0.0% | 0.10% | -9.6% | |
| SMIHU | SUMMIT HEALTHCRE ACQUISTN COunit 06/03/2026 | $5,060,000 | +2.7% | 500,000 | 0.0% | 0.10% | -9.6% | |
| ARYA SCIENCES ACQUISITN CORP | $5,045,000 | +3.0% | 500,000 | 0.0% | 0.10% | -8.8% | ||
| TENAYA THERAPEUTICS INC | $4,942,088 | -30.7% | 2,458,750 | 0.0% | 0.10% | -38.4% | ||
| Sell | DERMTECH INC | $4,811,490 | -61.0% | 2,718,356 | -12.8% | 0.10% | -65.6% | |
| AKYA | AKOYA BIOSCIENCES INC | $4,630,110 | -18.6% | 483,815 | 0.0% | 0.10% | -27.5% | |
| TELA | TELA BIO INC | $4,489,186 | +35.0% | 390,364 | 0.0% | 0.09% | +19.5% | |
| BWAY | BRAINSWAY LTDsponsored ads | $3,957,881 | -31.6% | 1,602,381 | 0.0% | 0.08% | -39.1% | |
| XGN | Buy | EXAGEN INC | $3,274,406 | +15.2% | 1,364,336 | +30.1% | 0.07% | +1.5% |
| JNJ | JOHNSON & JOHNSON | $3,202,135 | +8.1% | 18,127 | 0.0% | 0.06% | -4.4% | |
| MSAC | MEDICUS SCIENCES ACQUISITION | $3,021,000 | +1.7% | 300,000 | 0.0% | 0.06% | -8.8% | |
| THIRD HARMONIC BIO INC | $2,621,654 | -77.3% | 609,687 | 0.0% | 0.05% | -79.8% | ||
| MASS | 908 DEVICES INC | $2,377,440 | -53.7% | 312,000 | 0.0% | 0.05% | -58.5% | |
| LUNG | Sell | PULMONX CORP | $2,318,250 | -69.8% | 275,000 | -40.3% | 0.05% | -73.4% |
| Sell | NYXOAH S A | $1,347,265 | -38.0% | 269,993 | -21.7% | 0.03% | -44.0% | |
| Sell | SCIENCE 37 HOLDINGS INC | $1,073,752 | -84.6% | 2,586,108 | -40.3% | 0.02% | -86.3% | |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | $1,080,000 | -15.1% | 600,000 | 0.0% | 0.02% | -24.1% | |
| MIRO | MIROMATRIX MED INC | $837,200 | -31.7% | 280,000 | 0.0% | 0.02% | -39.3% | |
| MSACW | MEDICUS SCIENCES ACQUISITION*w exp 02/12/202 | $3,000 | +200.0% | 33,331 | 0.0% | 0.00% | – | |
| Exit | RENOVACOR INC*w exp 99/99/999 | $0 | – | -350,000 | -100.0% | -0.00% | – | |
| ASLN | Exit | ASLAN PHARMACEUTICALS LTDads | $0 | – | -3,015,987 | -100.0% | -0.04% | – |
| EPIX | Exit | ESSA PHARMA INC | $0 | – | -1,311,294 | -100.0% | -0.06% | – |
| LABP | Exit | LANDOS BIOPHARMA INC | $0 | – | -3,975,722 | -100.0% | -0.06% | – |
| FVAM | Exit | 5 01 ACQUISITION CORP | $0 | – | -392,000 | -100.0% | -0.09% | – |
| BLSA | Exit | BCLS ACQUISITION CORP | $0 | – | -612,500 | -100.0% | -0.14% | – |
| RACB | Exit | RESEARCH ALLIANCE CORP II | $0 | – | -637,000 | -100.0% | -0.14% | – |
| Exit | RENOVACOR INC | $0 | – | -3,000,803 | -100.0% | -0.17% | – | |
| TNDM | Exit | TANDEM DIABETES CARE INC | $0 | – | -322,000 | -100.0% | -0.36% | – |
| Exit | 2SEVENTY BIO INC | $0 | – | -1,229,508 | -100.0% | -0.41% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2023-02-14
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| ALNYLAM PHARMACEUTICALS INC | 36 | Q3 2023 | 19.7% |
| MASIMO CORP | 32 | Q3 2023 | 5.8% |
| LA JOLLA PHARMACEUTICAL CO | 31 | Q2 2022 | 9.7% |
| REGENXBIO INC | 30 | Q4 2022 | 10.8% |
| AGENUS INC | 29 | Q2 2022 | 9.0% |
| PTC THERAPEUTICS INC | 28 | Q3 2023 | 12.8% |
| DICERNA PHARMACEUTICALS INC | 28 | Q3 2021 | 10.8% |
| MIRATI THERAPEUTICS INC | 26 | Q3 2023 | 6.2% |
| ARGENX SE | 26 | Q3 2023 | 5.3% |
| VERICEL CORP | 24 | Q3 2023 | 3.9% |
View RTW INVESTMENTS, LP's complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| ROCKET PHARMACEUTICALS, INC. | September 19, 2023 | 18,188,457 | - |
| ALLURION TECHNOLOGIES, INC. | August 11, 2023 | 3,457,707 | 7.4% |
| Orchestra BioMed Holdings, Inc. | May 05, 2023 | 5,620,645 | 15.7% |
| Renovacor, Inc.Sold out | April 05, 2023 | 0 | - |
| Adverum Biotechnologies, Inc.Sold out | February 14, 2023 | 0 | 0.0% |
| Aptevo Therapeutics Inc.Sold out | February 14, 2023 | 0 | 0.0% |
| ASLAN Pharmaceuticals LtdSold out | February 14, 2023 | 0 | 0.0% |
| Athira Pharma, Inc.Sold out | February 14, 2023 | 0 | 0.0% |
| BELLUS Health Inc.Sold out | February 14, 2023 | 0 | 0.0% |
| Clearside Biomedical, Inc.Sold out | February 14, 2023 | 0 | 0.0% |
View RTW INVESTMENTS, LP's complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| SC 13D/A | 2024-04-17 |
| SC 13D/A | 2024-03-01 |
| 13F-HR | 2024-02-14 |
| SC 13G/A | 2024-02-14 |
| SC 13G/A | 2024-02-14 |
| SC 13G/A | 2024-02-14 |
| SC 13G/A | 2024-02-14 |
| SC 13G/A | 2024-02-14 |
| SC 13G/A | 2024-02-14 |
| SC 13G/A | 2024-02-14 |
View RTW INVESTMENTS, LP's complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.