RTW INVESTMENTS, LP Activity Q4 2014-Q3 2023

Q3 2023

			Value		Shares		↓ Weighting
IMCR	Buy	IMMUNOCORE HLDGS PLCads	$316,402,485	-12.5%	6,096,387	+1.1%	6.68%	-3.0%
AXSM	Buy	AXSOME THERAPEUTICS INC	$313,777,864	+1.9%	4,489,596	+4.8%	6.62%	+13.0%
MRTX	Buy	MIRATI THERAPEUTICS INC	$294,836,470	+82.4%	6,768,514	+51.3%	6.22%	+102.2%
ARGX	Buy	ARGENX SEsponsored adr	$249,352,278	+32.7%	507,195	+5.2%	5.26%	+47.0%
ACAD	Buy	ACADIA PHARMACEUTICALS INC	$241,255,031	+3.0%	11,576,537	+18.3%	5.09%	+14.1%
BRKR	Buy	BRUKER CORP	$210,680,097	-3.7%	3,381,703	+14.3%	4.44%	+6.7%
NTRA	Buy	NATERA INC	$117,341,398	-7.7%	2,651,783	+1.5%	2.48%	+2.4%
SAGE	New	SAGE THERAPEUTICS INC	$105,976,340	–	5,149,482	–	2.24%	–
AVDL	Buy	AVADEL PHARMACEUTICALS PLCsponsored adr	$73,505,075	-34.5%	7,136,415	+4.8%	1.55%	-27.4%
TXG	Buy	10X GENOMICS INC	$62,698,185	-23.3%	1,519,956	+3.9%	1.32%	-14.9%
TSHA	New	TAYSHA GENE THERAPIES INC	$53,382,465	–	16,893,185	–	1.13%	–
TARS	Buy	TARSUS PHARMACEUTICALS INC	$51,190,057	+11.2%	2,880,701	+13.1%	1.08%	+23.1%
INSM	Buy	INSMED INC	$47,093,977	+123.2%	1,865,108	+86.5%	0.99%	+147.3%
MRUS	Buy	MERUS N V	$47,083,695	+70.2%	1,996,764	+90.0%	0.99%	+88.4%
	New	APOGEE THERAPEUTICS INC	$45,637,188	–	2,142,591	–	0.96%	–
MDGL	Buy	MADRIGAL PHARMACEUTICALS INC	$45,197,189	-11.7%	309,485	+39.7%	0.95%	-2.1%
GHRS	Buy	GH RESEARCH PLCordinary shares	$33,437,646	+29.9%	3,327,129	+53.4%	0.70%	+43.9%
ILMN	Sell	ILLUMINA INC	$25,825,800	-63.4%	188,125	-50.0%	0.54%	-59.4%
FULC	Sell	FULCRUM THERAPEUTICS INC	$25,835,490	+29.1%	5,818,804	-4.0%	0.54%	+43.0%
ALKS	New	ALKERMES PLC	$24,902,935	–	889,073	–	0.52%	–
AXNX	Sell	AXONICS INC	$24,832,370	-44.4%	442,487	-50.0%	0.52%	-38.4%
SWAV	New	SHOCKWAVE MED INC	$24,688,400	–	124,000	–	0.52%	–
	New	ALLURION TECHNOLOGIES INC	$14,868,140	–	3,457,707	–	0.31%	–
PMVP	Sell	PMV PHARMACEUTICALS INC	$14,587,320	-23.1%	2,375,785	-21.6%	0.31%	-14.7%
SYK	New	STRYKER CORPORATION	$7,651,560	–	28,000	–	0.16%	–
IMUX	Buy	IMMUNIC INC	$6,372,825	-40.9%	4,335,255	+0.9%	0.13%	-34.6%
DSGN	Buy	DESIGN THERAPEUTICS INC	$5,930,647	-39.8%	2,512,986	+60.8%	0.12%	-33.2%
	New	SAGIMET BIOSCIENCES INC	$3,522,438	–	400,277	–	0.07%	–
VKTX	Sell	VIKING THERAPEUTICS INC	$2,871,558	-82.3%	259,400	-74.1%	0.06%	-80.3%
OLK	Sell	OLINK HLDG ABsponsored ads	$2,413,867	-80.3%	163,652	-75.0%	0.05%	-78.2%
	New	RAYZEBIO INC	$1,027,860	–	46,300	–	0.02%	–
	New	SIENTRA INC	$845,220	–	304,036	–	0.02%	–
MRSN	Exit	MERSANA THERAPEUTICS INC	$0	–	-614,838	–	-0.04%	–
BDTX	Exit	BLACK DIAMOND THERAPEUTICS I	$0	–	-1,700,000	–	-0.16%	–
MRVI	Exit	MARAVAI LIFESCIENCES HLDGS I	$0	–	-1,532,685	–	-0.36%	–
ISRG	Exit	INTUITIVE SURGICAL INC	$0	–	-170,000	–	-1.11%	–
HZNP	Exit	HORIZON THERAPEUTICS PUB L	$0	–	-1,000,000	–	-1.96%	–

Q2 2023

			Value		Shares		↓ Weighting
IMCR	New	IMMUNOCORE HLDGS PLCads	$361,536,795	–	6,029,633	–	6.88%	–
RCKT	New	ROCKET PHARMACEUTICALS INC	$351,456,030	–	17,687,772	–	6.69%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$319,737,778	–	1,683,362	–	6.09%	–
AXSM	New	AXSOME THERAPEUTICS INC	$307,868,145	–	4,284,277	–	5.86%	–
PTCT	New	PTC THERAPEUTICS INC	$294,255,421	–	7,235,196	–	5.60%	–
RARE	New	ULTRAGENYX PHARMACEUTICAL IN	$249,336,756	–	5,405,089	–	4.75%	–
MASI	New	MASIMO CORP	$247,070,673	–	1,501,493	–	4.70%	–
ACAD	New	ACADIA PHARMACEUTICALS INC	$234,308,814	–	9,783,249	–	4.46%	–
PEN	New	PENUMBRA INC	$231,680,026	–	673,371	–	4.41%	–
BRKR	New	BRUKER CORP	$218,773,854	–	2,959,603	–	4.16%	–
ARGX	New	ARGENX SEsponsored adr	$187,925,857	–	482,195	–	3.58%	–
ESTA	New	ESTABLISHMENT LABS HLDGS INC	$171,122,808	–	2,494,138	–	3.26%	–
MRTX	New	MIRATI THERAPEUTICS INC	$161,608,948	–	4,472,985	–	3.08%	–
TMO	New	THERMO FISHER SCIENTIFIC INC	$151,481,765	–	290,334	–	2.88%	–
PTGX	New	PROTAGONIST THERAPEUTICS INC	$149,576,497	–	5,415,514	–	2.85%	–
NTRA	New	NATERA INC	$127,089,361	–	2,611,783	–	2.42%	–
VCEL	New	VERICEL CORP	$123,675,669	–	3,291,873	–	2.35%	–
CLDX	New	CELLDEX THERAPEUTICS INC NEW	$117,506,410	–	3,463,201	–	2.24%	–
AVDL	New	AVADEL PHARMACEUTICALS PLCsponsored adr	$112,239,364	–	6,810,641	–	2.14%	–
HZNP	New	HORIZON THERAPEUTICS PUB L	$102,850,000	–	1,000,000	–	1.96%	–
CYTK	New	CYTOKINETICS INC	$83,970,339	–	2,574,198	–	1.60%	–
TXG	New	10X GENOMICS INC	$81,691,463	–	1,462,956	–	1.56%	–
RNA	New	AVIDITY BIOSCIENCES INC	$74,189,760	–	6,689,789	–	1.41%	–
ILMN	New	ILLUMINA INC	$70,543,113	–	376,250	–	1.34%	–
ISRG	New	INTUITIVE SURGICAL INC	$58,129,800	–	170,000	–	1.11%	–
MDGL	New	MADRIGAL PHARMACEUTICALS INC	$51,180,822	–	221,562	–	0.97%	–
STOK	New	STOKE THERAPEUTICS INC	$46,671,632	–	4,390,558	–	0.89%	–
TARS	New	TARSUS PHARMACEUTICALS INC	$46,044,619	–	2,548,125	–	0.88%	–
AXNX	New	AXONICS INC	$44,664,638	–	884,974	–	0.85%	–
	New	ORCHESTRA BIOMED HLDGS INC	$39,344,480	–	5,620,640	–	0.75%	–
SCPH	New	SCPHARMACEUTICALS INC	$33,605,020	–	3,297,843	–	0.64%	–
CUTR	New	CUTERA INC	$27,938,997	–	1,846,596	–	0.53%	–
MRUS	New	MERUS N V	$27,670,013	–	1,050,893	–	0.53%	–
GHRS	New	GH RESEARCH PLCordinary shares	$25,734,675	–	2,168,957	–	0.49%	–
	New	MOONLAKE IMMUNOTHERAPEUTICSclass a ord	$25,500,000	–	500,000	–	0.48%	–
INSM	New	INSMED INC	$21,100,000	–	1,000,000	–	0.40%	–
	New	ACELYRIN INC	$20,446,679	–	978,310	–	0.39%	–
FULC	New	FULCRUM THERAPEUTICS INC	$20,011,606	–	6,064,123	–	0.38%	–
MRVI	New	MARAVAI LIFESCIENCES HLDGS I	$19,051,275	–	1,532,685	–	0.36%	–
PMVP	New	PMV PHARMACEUTICALS INC	$18,964,989	–	3,029,551	–	0.36%	–
GH	New	GUARDANT HEALTH INC	$17,931,755	–	500,887	–	0.34%	–
OM	New	OUTSET MED INC	$17,685,350	–	808,658	–	0.34%	–
VKTX	New	VIKING THERAPEUTICS INC	$16,210,000	–	1,000,000	–	0.31%	–
	New	MINERALYS THERAPEUTICS INC	$15,721,805	–	922,100	–	0.30%	–
	New	ROIVANT SCIENCES LTD	$15,651,387	–	1,552,717	–	0.30%	–
OLK	New	OLINK HLDG ABsponsored ads	$12,273,975	–	654,612	–	0.23%	–
IMUX	New	IMMUNIC INC	$10,779,092	–	4,294,459	–	0.20%	–
ACET	New	ADICET BIO INC	$10,306,777	–	4,241,472	–	0.20%	–
DSGN	New	DESIGN THERAPEUTICS INC	$9,847,095	–	1,563,031	–	0.19%	–
IMTX	New	IMMATICS N.V	$9,751,300	–	845,000	–	0.19%	–
MIST	New	MILESTONE PHARMACEUTICALS IN	$9,279,891	–	3,256,102	–	0.18%	–
APYX	New	APYX MEDICAL CORPORATION	$8,939,286	–	1,777,194	–	0.17%	–
URGN	New	UROGEN PHARMA LTD	$8,874,752	–	857,464	–	0.17%	–
BDTX	New	BLACK DIAMOND THERAPEUTICS I	$8,585,000	–	1,700,000	–	0.16%	–
	New	DERMTECH INC	$7,067,726	–	2,718,356	–	0.14%	–
RLMD	New	RELMADA THERAPEUTICS INC	$5,244,314	–	2,131,835	–	0.10%	–
XGN	New	EXAGEN INC	$4,328,053	–	1,492,432	–	0.08%	–
AKYA	New	AKOYA BIOSCIENCES INC	$2,500,939	–	338,422	–	0.05%	–
MRSN	New	MERSANA THERAPEUTICS INC	$2,022,817	–	614,838	–	0.04%	–
ARYD	New	ARYA SCIENCES ACQU CORP IVcl a	$1,347,524	–	127,970	–	0.03%	–
MIRO	New	MIROMATRIX MED INC	$779,139	–	445,222	–	0.02%	–
	New	ROCKET PHARMACEUTICALS INC*w exp 09/02/202	$66,500	–	350,000	–	0.00%	–

Q4 2022

			Value		Shares		↓ Weighting
MSACW	Exit	MEDICUS SCIENCES ACQUISITION*w exp 02/12/202	$0	–	-33,331	–	0.00%	–
	Exit	RENOVACOR INC*w exp 99/99/999	$0	–	-350,000	–	-0.00%	–
MIRO	Exit	MIROMATRIX MED INC	$0	–	-280,000	–	-0.03%	–
NAUT	Exit	NAUTILUS BIOTECHNOLOGY INC	$0	–	-600,000	–	-0.03%	–
ASLN	Exit	ASLAN PHARMACEUTICALS LTDads	$0	–	-3,015,987	–	-0.04%	–
	Exit	NYXOAH S A	$0	–	-344,911	–	-0.05%	–
EPIX	Exit	ESSA PHARMA INC	$0	–	-1,311,294	–	-0.06%	–
LABP	Exit	LANDOS BIOPHARMA INC	$0	–	-3,975,722	–	-0.06%	–
	Exit	ROIVANT SCIENCES LTD	$0	–	-802,717	–	-0.06%	–
XGN	Exit	EXAGEN INC	$0	–	-1,048,662	–	-0.07%	–
JNJ	Exit	JOHNSON & JOHNSON	$0	–	-18,127	–	-0.07%	–
MSAC	Exit	MEDICUS SCIENCES ACQUISITION	$0	–	-300,000	–	-0.07%	–
TELA	Exit	TELA BIO INC	$0	–	-390,364	–	-0.08%	–
IMTX	Exit	IMMATICS N.V	$0	–	-350,000	–	-0.08%	–
	Exit	MOONLAKE IMMUNOTHERAPEUTICSclass a ord	$0	–	-500,000	–	-0.09%	–
FVAM	Exit	5 01 ACQUISITION CORP	$0	–	-392,000	–	-0.09%	–
	Exit	SIGHT SCIENCES INC	$0	–	-665,323	–	-0.10%	–
	Exit	ARYA SCIENCES ACQUISITN CORP	$0	–	-500,000	–	-0.11%	–
ARYD	Exit	ARYA SCIENCES ACQU CORP IVcl a	$0	–	-500,000	–	-0.11%	–
SMIHU	Exit	SUMMIT HEALTHCRE ACQUISTN COunit 06/03/2026	$0	–	-500,000	–	-0.11%	–
MASS	Exit	908 DEVICES INC	$0	–	-312,000	–	-0.12%	–
AKYA	Exit	AKOYA BIOSCIENCES INC	$0	–	-483,815	–	-0.13%	–
BWAY	Exit	BRAINSWAY LTDsponsored ads	$0	–	-1,602,381	–	-0.13%	–
BLSA	Exit	BCLS ACQUISITION CORP	$0	–	-612,500	–	-0.14%	–
RACB	Exit	RESEARCH ALLIANCE CORP II	$0	–	-637,000	–	-0.14%	–
	Exit	SCIENCE 37 HOLDINGS INC	$0	–	-4,328,387	–	-0.16%	–
	Exit	TENAYA THERAPEUTICS INC	$0	–	-2,458,750	–	-0.16%	–
URGN	Exit	UROGEN PHARMA LTD	$0	–	-857,464	–	-0.16%	–
	Exit	RENOVACOR INC	$0	–	-3,000,803	–	-0.17%	–
LUNG	Exit	PULMONX CORP	$0	–	-460,847	–	-0.18%	–
IMUX	Exit	IMMUNIC INC	$0	–	-2,761,968	–	-0.20%	–
HSAQ	Exit	HEALTH SCIENCES ACQ CORP 2	$0	–	-1,000,000	–	-0.23%	–
GLUE	Exit	MONTE ROSA THERAPEUTICS INC	$0	–	-1,214,572	–	-0.23%	–
ALLK	Exit	ALLAKOS INC	$0	–	-1,643,500	–	-0.23%	–
	Exit	AADI BIOSCIENCE INC	$0	–	-764,701	–	-0.25%	–
OYST	Exit	OYSTER PT PHARMA INC	$0	–	-2,044,312	–	-0.26%	–
	Exit	THIRD HARMONIC BIO INC	$0	–	-609,687	–	-0.27%	–
JNCE	Exit	JOUNCE THERAPEUTICS INC	$0	–	-5,106,341	–	-0.28%	–
OLK	Exit	OLINK HLDG ABsponsored ads	$0	–	-981,918	–	-0.28%	–
	Exit	DERMTECH INC	$0	–	-3,118,666	–	-0.28%	–
CSTL	Exit	CASTLE BIOSCIENCES INC	$0	–	-516,995	–	-0.31%	–
OM	Exit	OUTSET MED INC	$0	–	-909,652	–	-0.33%	–
APYX	Exit	APYX MEDICAL CORPORATION	$0	–	-3,398,279	–	-0.35%	–
TNDM	Exit	TANDEM DIABETES CARE INC	$0	–	-322,000	–	-0.36%	–
	Exit	2SEVENTY BIO INC	$0	–	-1,229,508	–	-0.41%	–
TXG	Exit	10X GENOMICS INC	$0	–	-639,654	–	-0.42%	–
CCCC	Exit	C4 THERAPEUTICS INC	$0	–	-2,819,472	–	-0.57%	–
GHRS	Exit	GH RESEARCH PLCordinary shares	$0	–	-2,168,957	–	-0.58%	–
AVDL	Exit	AVADEL PHARMACEUTICALS PLCsponsored adr	$0	–	-5,741,939	–	-0.66%	–
BCYC	Exit	BICYCLE THERAPEUTICS PLCsponsored ads	$0	–	-1,276,276	–	-0.68%	–
FULC	Exit	FULCRUM THERAPEUTICS INC	$0	–	-3,985,910	–	-0.74%	–
TARS	Exit	TARSUS PHARMACEUTICALS INC	$0	–	-2,023,179	–	-0.80%	–
PTGX	Exit	PROTAGONIST THERAPEUTICS INC	$0	–	-4,176,837	–	-0.81%	–
GH	Exit	GUARDANT HEALTH INC	$0	–	-725,887	–	-0.90%	–
MIST	Exit	MILESTONE PHARMACEUTICALS IN	$0	–	-4,315,102	–	-0.91%	–
GMED	Exit	GLOBUS MED INCcl a	$0	–	-747,685	–	-1.03%	–
	Exit	CINCOR PHARMA INC	$0	–	-1,389,705	–	-1.05%	–
STOK	Exit	STOKE THERAPEUTICS INC	$0	–	-3,651,823	–	-1.08%	–
RGNX	Exit	REGENXBIO INC	$0	–	-1,845,366	–	-1.12%	–
PMVP	Exit	PMV PHARMACEUTICALS INC	$0	–	-4,356,920	–	-1.20%	–
	Exit	VENTYX BIOSCIENCES INC	$0	–	-1,551,778	–	-1.25%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INC	$0	–	-3,670,938	–	-1.38%	–
ACET	Exit	ADICET BIO INC	$0	–	-4,241,472	–	-1.39%	–
AXNX	Exit	AXONICS INC	$0	–	-884,974	–	-1.44%	–
ISEE	Exit	IVERIC BIO INC	$0	–	-3,625,000	–	-1.50%	–
VCEL	Exit	VERICEL CORP	$0	–	-3,099,904	–	-1.66%	–
CUTR	Exit	CUTERA INC	$0	–	-1,770,400	–	-1.86%	–
AXSM	Exit	AXSOME THERAPEUTICS INC	$0	–	-1,882,164	–	-1.94%	–
RNA	Exit	AVIDITY BIOSCIENCES INC	$0	–	-5,170,784	–	-1.95%	–
CLDX	Exit	CELLDEX THERAPEUTICS INC NEW	$0	–	-3,084,215	–	-2.00%	–
NTRA	Exit	NATERA INC	$0	–	-2,209,283	–	-2.23%	–
RARE	Exit	ULTRAGENYX PHARMACEUTICAL IN	$0	–	-2,359,996	–	-2.25%	–
RLMD	Exit	RELMADA THERAPEUTICS INC	$0	–	-2,644,475	–	-2.26%	–
ILMN	Exit	ILLUMINA INC	$0	–	-564,375	–	-2.48%	–
CYTK	Exit	CYTOKINETICS INC	$0	–	-2,574,198	–	-2.88%	–
ESTA	Exit	ESTABLISHMENT LABS HLDGS INC	$0	–	-2,369,138	–	-2.98%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-1,882,663	–	-3.03%	–
PEN	Exit	PENUMBRA INC	$0	–	-698,371	–	-3.05%	–
ARGX	Exit	ARGENX SEsponsored adr	$0	–	-467,195	–	-3.80%	–
RXDX	Exit	PROMETHEUS BIOSCIENCES INC	$0	–	-3,189,605	–	-4.34%	–
MASI	Exit	MASIMO CORP	$0	–	-1,439,993	–	-4.69%	–
IMCR	Exit	IMMUNOCORE HLDGS PLCads	$0	–	-4,451,483	–	-4.82%	–
TMO	Exit	THERMO FISHER SCIENTIFIC INC	$0	–	-435,500	–	-5.09%	–
RCKT	Exit	ROCKET PHARMACEUTICALS INC	$0	–	-15,802,802	–	-5.82%	–
PTCT	Exit	PTC THERAPEUTICS INC	$0	–	-5,620,580	–	-6.50%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INC	$0	–	-1,683,362	–	-7.77%	–

Q3 2022

			Value		Shares		↓ Weighting
PTCT	Buy	PTC THERAPEUTICS INC	$282,153,000	+39.6%	5,620,580	+11.4%	6.50%	+24.6%
IMCR	Buy	IMMUNOCORE HLDGS PLCads	$208,953,000	+40.1%	4,451,483	+11.4%	4.82%	+25.1%
MASI	Buy	MASIMO CORP	$203,269,000	+15.1%	1,439,993	+6.6%	4.69%	+2.7%
ARGX	Buy	ARGENX SEsponsored adr	$164,943,000	-1.6%	467,195	+5.5%	3.80%	-12.2%
CYTK	Buy	CYTOKINETICS INC	$124,720,000	+23.9%	2,574,198	+0.5%	2.88%	+10.6%
RLMD	Buy	RELMADA THERAPEUTICS INC	$97,898,000	+95.5%	2,644,475	+0.3%	2.26%	+74.4%
RARE	Buy	ULTRAGENYX PHARMACEUTICAL IN	$97,727,000	+19.3%	2,359,996	+71.9%	2.25%	+6.4%
NTRA	Buy	NATERA INC	$96,811,000	+28.7%	2,209,283	+4.1%	2.23%	+14.9%
RNA	Buy	AVIDITY BIOSCIENCES INC	$84,439,000	+21.2%	5,170,784	+7.8%	1.95%	+8.2%
AXSM	Buy	AXSOME THERAPEUTICS INC	$83,982,000	+35.5%	1,882,164	+16.3%	1.94%	+20.8%
VCEL	Sell	VERICEL CORP	$71,918,000	-18.9%	3,099,904	-12.0%	1.66%	-27.7%
ISEE	New	IVERIC BIO INC	$65,033,000	–	3,625,000	–	1.50%	–
AXNX	Sell	AXONICS INC	$62,338,000	-6.8%	884,974	-25.0%	1.44%	-16.8%
ACET	Buy	ADICET BIO INC	$60,314,000	+4.6%	4,241,472	+7.3%	1.39%	-6.8%
ACAD	Sell	ACADIA PHARMACEUTICALS INC	$60,057,000	+0.9%	3,670,938	-13.1%	1.38%	-9.9%
PMVP	Sell	PMV PHARMACEUTICALS INC	$51,847,000	-17.2%	4,356,920	-0.9%	1.20%	-26.1%
GMED	Sell	GLOBUS MED INCcl a	$44,540,000	-29.3%	747,685	-33.3%	1.03%	-36.9%
GH	Sell	GUARDANT HEALTH INC	$39,074,000	+4.7%	725,887	-21.5%	0.90%	-6.5%
PTGX	Sell	PROTAGONIST THERAPEUTICS INC	$35,211,000	-7.2%	4,176,837	-12.9%	0.81%	-17.1%
TARS	Buy	TARSUS PHARMACEUTICALS INC	$34,637,000	+17.8%	2,023,179	+0.5%	0.80%	+5.1%
FULC	Buy	FULCRUM THERAPEUTICS INC	$32,246,000	+66.1%	3,985,910	+0.6%	0.74%	+48.3%
CCCC	Sell	C4 THERAPEUTICS INC	$24,727,000	+6.0%	2,819,472	-8.9%	0.57%	-5.5%
TXG	Sell	10X GENOMICS INC	$18,217,000	-58.0%	639,654	-33.3%	0.42%	-62.6%
TNDM	Sell	TANDEM DIABETES CARE INC	$15,408,000	-71.8%	322,000	-65.1%	0.36%	-74.8%
CSTL	Sell	CASTLE BIOSCIENCES INC	$13,483,000	-32.8%	516,995	-43.4%	0.31%	-40.0%
JNCE	Buy	JOUNCE THERAPEUTICS INC	$11,949,000	-9.5%	5,106,341	+17.2%	0.28%	-19.4%
OLK	Sell	OLINK HLDG ABsponsored ads	$11,920,000	-49.8%	981,918	-37.1%	0.28%	-55.2%
	New	THIRD HARMONIC BIO INC	$11,566,000	–	609,687	–	0.27%	–
OYST	Sell	OYSTER PT PHARMA INC	$11,489,000	+28.9%	2,044,312	-0.7%	0.26%	+15.2%
ALLK	New	ALLAKOS INC	$10,058,000	–	1,643,500	–	0.23%	–
HSAQ	New	HEALTH SCIENCES ACQ CORP 2	$9,900,000	–	1,000,000	–	0.23%	–
LUNG	Sell	PULMONX CORP	$7,678,000	-24.5%	460,847	-33.3%	0.18%	-32.7%
	Buy	SCIENCE 37 HOLDINGS INC	$6,969,000	-19.1%	4,328,387	+1.0%	0.16%	-27.8%
AKYA	Buy	AKOYA BIOSCIENCES INC	$5,685,000	+89.4%	483,815	+107.2%	0.13%	+67.9%
MASS	Sell	908 DEVICES INC	$5,132,000	-51.4%	312,000	-39.2%	0.12%	-56.8%
	Sell	SIGHT SCIENCES INC	$4,225,000	-52.9%	665,323	-33.3%	0.10%	-58.2%
TELA	Sell	TELA BIO INC	$3,326,000	-53.4%	390,364	-61.6%	0.08%	-58.2%
XGN	Buy	EXAGEN INC	$2,842,000	-51.7%	1,048,662	+2.3%	0.07%	-56.6%
LABP	Sell	LANDOS BIOPHARMA INC	$2,584,000	-17.0%	3,975,722	-7.0%	0.06%	-25.0%
EPIX	Sell	ESSA PHARMA INC	$2,387,000	-71.3%	1,311,294	-50.3%	0.06%	-74.4%
ASLN	Sell	ASLAN PHARMACEUTICALS LTDads	$1,806,000	+12.2%	3,015,987	-7.2%	0.04%	0.0%
NAUT	Sell	NAUTILUS BIOTECHNOLOGY INC	$1,272,000	-57.0%	600,000	-45.5%	0.03%	-61.8%
DNAY	Exit	CODEX DNA INC	$0	–	-100,000	–	-0.01%	–
	Exit	MINERVA SURGICAL INC	$0	–	-166,000	–	-0.01%	–
OMIC	Exit	SINGULAR GENOMICS SYSTEMS IN	$0	–	-100,000	–	-0.01%	–
RCEL	Exit	AVITA MEDICAL INC	$0	–	-106,667	–	-0.01%	–
	Exit	ISOPLEXIS CORP	$0	–	-365,000	–	-0.02%	–
APEN	Exit	APOLLO ENDOSURGERY INC	$0	–	-258,064	–	-0.02%	–
	Exit	PYXIS ONCOLOGY INC	$0	–	-682,220	–	-0.04%	–
GTH	Exit	GENETRON HLDGS LTDads	$0	–	-1,198,961	–	-0.05%	–
	Exit	RXSIGHT INC	$0	–	-150,000	–	-0.06%	–
CTIC	Exit	CTI BIOPHARMA CORP	$0	–	-471,630	–	-0.07%	–
AGEN	Exit	AGENUS INC	$0	–	-1,583,822	–	-0.08%	–
PNT	Exit	POINT BIOPHARMA GLOBAL INC	$0	–	-490,000	–	-0.09%	–
	Exit	MAXCYTE INC	$0	–	-772,735	–	-0.09%	–
CTMX	Exit	CYTOMX THERAPEUTICS INC	$0	–	-2,849,707	–	-0.14%	–
	Exit	PROCEPT BIOROBOTICS CORP	$0	–	-161,138	–	-0.14%	–
LJPC	Exit	LA JOLLA PHARMACEUTICAL CO	$0	–	-2,327,403	–	-0.19%	–
TWST	Exit	TWIST BIOSCIENCE CORP	$0	–	-270,000	–	-0.24%	–
	Exit	SOMALOGIC INC	$0	–	-2,114,830	–	-0.25%	–
CDXS	Exit	CODEXIS INC	$0	–	-920,448	–	-0.25%	–
	Exit	CYTEK BIOSCIENCES INC	$0	–	-916,838	–	-0.25%	–
ALGN	Exit	ALIGN TECHNOLOGY INC	$0	–	-42,000	–	-0.26%	–
CYRX	Exit	CRYOPORT INC	$0	–	-335,299	–	-0.27%	–
MGNX	Exit	MACROGENICS INC	$0	–	-3,975,554	–	-0.30%	–
VERU	Exit	VERU INC	$0	–	-2,220,983	–	-0.65%	–
QTRX	Exit	QUANTERIX CORP	$0	–	-1,819,120	–	-0.76%	–

Q2 2022

			Value		Shares		↓ Weighting
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$245,518,000	–	1,683,362	–	6.34%	–
TMO	New	THERMO FISHER SCIENTIFIC INC	$236,598,000	–	435,500	–	6.11%	–
RCKT	New	ROCKET PHARMACEUTICALS INC	$217,447,000	–	15,802,802	–	5.62%	–
PTCT	New	PTC THERAPEUTICS INC	$202,115,000	–	5,045,307	–	5.22%	–
MASI	New	MASIMO CORP	$176,534,000	–	1,350,993	–	4.56%	–
ARGX	New	ARGENX SEsponsored adr	$167,706,000	–	442,635	–	4.33%	–
IMCR	New	IMMUNOCORE HLDGS PLCads	$149,097,000	–	3,996,154	–	3.85%	–
ESTA	New	ESTABLISHMENT LABS HLDGS INC	$128,834,000	–	2,369,138	–	3.33%	–
MRTX	New	MIRATI THERAPEUTICS INC	$126,383,000	–	1,882,663	–	3.26%	–
ILMN	New	ILLUMINA INC	$104,048,000	–	564,375	–	2.69%	–
CYTK	New	CYTOKINETICS INC	$100,629,000	–	2,561,182	–	2.60%	–
RXDX	New	PROMETHEUS BIOSCIENCES INC	$90,043,000	–	3,189,605	–	2.33%	–
VCEL	New	VERICEL CORP	$88,707,000	–	3,522,904	–	2.29%	–
PEN	New	PENUMBRA INC	$86,961,000	–	698,371	–	2.25%	–
CLDX	New	CELLDEX THERAPEUTICS INC NEW	$83,150,000	–	3,084,215	–	2.15%	–
RARE	New	ULTRAGENYX PHARMACEUTICAL IN	$81,930,000	–	1,373,284	–	2.12%	–
NTRA	New	NATERA INC	$75,214,000	–	2,122,283	–	1.94%	–
RNA	New	AVIDITY BIOSCIENCES INC	$69,671,000	–	4,795,000	–	1.80%	–
AXNX	New	AXONICS INC	$66,869,000	–	1,179,965	–	1.73%	–
CUTR	New	CUTERA INC	$66,390,000	–	1,770,400	–	1.72%	–
GMED	New	GLOBUS MED INCcl a	$62,963,000	–	1,121,527	–	1.63%	–
PMVP	New	PMV PHARMACEUTICALS INC	$62,638,000	–	4,395,677	–	1.62%	–
AXSM	New	AXSOME THERAPEUTICS INC	$62,001,000	–	1,618,819	–	1.60%	–
ACAD	New	ACADIA PHARMACEUTICALS INC	$59,518,000	–	4,224,109	–	1.54%	–
ACET	New	ADICET BIO INC	$57,689,000	–	3,951,281	–	1.49%	–
TNDM	New	TANDEM DIABETES CARE INC	$54,610,000	–	922,630	–	1.41%	–
RLMD	New	RELMADA THERAPEUTICS INC	$50,088,000	–	2,637,581	–	1.29%	–
STOK	New	STOKE THERAPEUTICS INC	$48,241,000	–	3,651,823	–	1.25%	–
RGNX	New	REGENXBIO INC	$45,581,000	–	1,845,366	–	1.18%	–
TXG	New	10X GENOMICS INC	$43,417,000	–	959,481	–	1.12%	–
PTGX	New	PROTAGONIST THERAPEUTICS INC	$37,924,000	–	4,794,499	–	0.98%	–
GH	New	GUARDANT HEALTH INC	$37,310,000	–	924,887	–	0.96%	–
QTRX	New	QUANTERIX CORP	$29,452,000	–	1,819,120	–	0.76%	–
TARS	New	TARSUS PHARMACEUTICALS INC	$29,399,000	–	2,013,601	–	0.76%	–
MIST	New	MILESTONE PHARMACEUTICALS IN	$26,538,000	–	4,315,102	–	0.69%	–
	New	CINCOR PHARMA INC	$26,182,000	–	1,389,705	–	0.68%	–
VERU	New	VERU INC	$25,097,000	–	2,220,983	–	0.65%	–
OLK	New	OLINK HLDG ABsponsored ads	$23,746,000	–	1,562,222	–	0.61%	–
CCCC	New	C4 THERAPEUTICS INC	$23,335,000	–	3,094,825	–	0.60%	–
GHRS	New	GH RESEARCH PLCordinary shares	$21,646,000	–	2,168,957	–	0.56%	–
BCYC	New	BICYCLE THERAPEUTICS PLCsponsored ads	$21,416,000	–	1,276,276	–	0.55%	–
CSTL	New	CASTLE BIOSCIENCES INC	$20,058,000	–	913,789	–	0.52%	–
APYX	New	APYX MEDICAL CORPORATION	$19,914,000	–	3,398,279	–	0.52%	–
FULC	New	FULCRUM THERAPEUTICS INC	$19,410,000	–	3,961,194	–	0.50%	–
	New	VENTYX BIOSCIENCES INC	$18,978,000	–	1,551,778	–	0.49%	–
	New	DERMTECH INC	$17,277,000	–	3,118,666	–	0.45%	–
	New	2SEVENTY BIO INC	$16,230,000	–	1,229,508	–	0.42%	–
AVDL	New	AVADEL PHARMACEUTICALS PLCsponsored adr	$14,010,000	–	5,741,939	–	0.36%	–
	New	TENAYA THERAPEUTICS INC	$13,843,000	–	2,458,750	–	0.36%	–
OM	New	OUTSET MED INC	$13,517,000	–	909,652	–	0.35%	–
JNCE	New	JOUNCE THERAPEUTICS INC	$13,206,000	–	4,358,433	–	0.34%	–
MGNX	New	MACROGENICS INC	$11,728,000	–	3,975,554	–	0.30%	–
GLUE	New	MONTE ROSA THERAPEUTICS INC	$11,745,000	–	1,214,572	–	0.30%	–
MASS	New	908 DEVICES INC	$10,562,000	–	512,957	–	0.27%	–
CYRX	New	CRYOPORT INC	$10,388,000	–	335,299	–	0.27%	–
LUNG	New	PULMONX CORP	$10,175,000	–	691,255	–	0.26%	–
ALGN	New	ALIGN TECHNOLOGY INC	$9,940,000	–	42,000	–	0.26%	–
	New	CYTEK BIOSCIENCES INC	$9,838,000	–	916,838	–	0.25%	–
CDXS	New	CODEXIS INC	$9,628,000	–	920,448	–	0.25%	–
IMUX	New	IMMUNIC INC	$9,584,000	–	2,761,968	–	0.25%	–
	New	SOMALOGIC INC	$9,559,000	–	2,114,830	–	0.25%	–
TWST	New	TWIST BIOSCIENCE CORP	$9,439,000	–	270,000	–	0.24%	–
	New	AADI BIOSCIENCES INC	$9,421,000	–	764,701	–	0.24%	–
	New	SIGHT SCIENCES INC	$8,964,000	–	997,099	–	0.23%	–
OYST	New	OYSTER PT PHARMA INC	$8,913,000	–	2,058,504	–	0.23%	–
	New	SCIENCE 37 HOLDINGS INC	$8,618,000	–	4,287,546	–	0.22%	–
EPIX	New	ESSA PHARMA INC	$8,307,000	–	2,637,192	–	0.22%	–
BWAY	New	BRAINSWAY LTDsponsored ads	$7,740,000	–	1,602,381	–	0.20%	–
LJPC	New	LA JOLLA PHARMACEUTICAL CO	$7,424,000	–	2,327,403	–	0.19%	–
TELA	New	TELA BIO INC	$7,133,000	–	1,017,546	–	0.18%	–
URGN	New	UROGEN PHARMA LTD	$7,023,000	–	857,464	–	0.18%	–
RACB	New	RESEARCH ALLIANCE CORP II	$6,223,000	–	637,000	–	0.16%	–
	New	RENOVACOR INC	$6,085,000	–	3,000,803	–	0.16%	–
BLSA	New	BCLS ACQUISITION CORP	$6,064,000	–	612,500	–	0.16%	–
XGN	New	EXAGEN INC	$5,884,000	–	1,025,002	–	0.15%	–
	New	PROCEPT BIOROBOTICS CORP	$5,268,000	–	161,138	–	0.14%	–
CTMX	New	CYTOMX THERAPEUTICS INC	$5,215,000	–	2,849,707	–	0.14%	–
ARYD	New	ARYA SCIENCES ACQU CORP IVcl a	$4,905,000	–	500,000	–	0.13%	–
SMIHU	New	SUMMIT HEALTHCRE ACQUISTN COunit 06/03/2026	$4,875,000	–	500,000	–	0.13%	–
	New	ARYA SCIENCES ACQUISITN CORP	$4,860,000	–	500,000	–	0.13%	–
FVAM	New	5 01 ACQUISITION CORP	$3,877,000	–	392,000	–	0.10%	–
	New	MAXCYTE INC	$3,655,000	–	772,735	–	0.09%	–
PNT	New	POINT BIOPHARMA GLOBAL INC	$3,337,000	–	490,000	–	0.09%	–
	New	ROIVANT SCIENCES LTD	$3,267,000	–	802,717	–	0.08%	–
JNJ	New	JOHNSON & JOHNSON	$3,218,000	–	18,127	–	0.08%	–
	New	NYXOAH S A	$3,173,000	–	344,911	–	0.08%	–
LABP	New	LANDOS BIOPHARMA INC	$3,112,000	–	4,275,722	–	0.08%	–
IMTX	New	IMMATICS N.V	$3,049,000	–	350,000	–	0.08%	–
AGEN	New	AGENUS INC	$3,073,000	–	1,583,822	–	0.08%	–
AKYA	New	AKOYA BIOSCIENCES INC	$3,001,000	–	233,557	–	0.08%	–
MSAC	New	MEDICUS SCIENCES ACQUISITION	$2,934,000	–	300,000	–	0.08%	–
NAUT	New	NAUTILUS BIOTECHNOLOGY INC	$2,959,000	–	1,100,000	–	0.08%	–
CTIC	New	CTI BIOPHARMA CORP	$2,816,000	–	471,630	–	0.07%	–
	New	MOONLAKE IMMUNOTHERAPEUTICSclass a ord	$2,625,000	–	500,000	–	0.07%	–
	New	RXSIGHT INC	$2,112,000	–	150,000	–	0.06%	–
GTH	New	GENETRON HLDGS LTDads	$2,038,000	–	1,198,961	–	0.05%	–
	New	PYXIS ONCOLOGY INC	$1,624,000	–	682,220	–	0.04%	–
ASLN	New	ASLAN PHARMACEUTICALS LTDads	$1,609,000	–	3,250,000	–	0.04%	–
MIRO	New	MIROMATRIX MED INC	$1,117,000	–	280,000	–	0.03%	–
APEN	New	APOLLO ENDOSURGERY INC	$942,000	–	258,064	–	0.02%	–
	New	ISOPLEXIS CORP	$788,000	–	365,000	–	0.02%	–
RCEL	New	AVITA MEDICAL INC	$507,000	–	106,667	–	0.01%	–
OMIC	New	SINGULAR GENOMICS SYSTEMS IN	$382,000	–	100,000	–	0.01%	–
	New	MINERVA SURGICAL INC	$390,000	–	166,000	–	0.01%	–
DNAY	New	CODEX DNA INC	$180,000	–	100,000	–	0.01%	–
	New	RENOVACOR INC*w exp 99/99/999	$21,000	–	350,000	–	0.00%	–
MSACW	New	MEDICUS SCIENCES ACQUISITION*w exp 02/12/202	$6,000	–	33,331	–	0.00%	–

Q4 2021

			Value		Shares		↓ Weighting
MSACW	Exit	MEDICUS SCIENCES ACQUISITION*w exp 02/12/202	$0	–	-33,331	–	0.00%	–
	Exit	RENOVACOR INC*w exp 99/99/999	$0	–	-350,000	–	-0.00%	–
BNR	Exit	BURNING ROCK BIOTECH LTDsponsored ads	$0	–	-30,000	–	-0.01%	–
ZY	Exit	ZYMERGEN INC	$0	–	-70,000	–	-0.01%	–
OMIC	Exit	SINGULAR GENOMICS SYSTEMS IN	$0	–	-100,000	–	-0.02%	–
MASS	Exit	908 DEVICES INC	$0	–	-40,000	–	-0.02%	–
AKYA	Exit	AKOYA BIOSCIENCES INC	$0	–	-100,000	–	-0.02%	–
BOLT	Exit	BOLT BIOTHERAPEUTICS INC	$0	–	-126,365	–	-0.02%	–
MDXG	Exit	MIMEDX GROUP INC	$0	–	-295,748	–	-0.03%	–
PROF	Exit	PROFOUND MED CORP	$0	–	-122,098	–	-0.03%	–
MIRO	Exit	MIROMATRIX MED INC	$0	–	-280,000	–	-0.03%	–
	Exit	RXSIGHT INC	$0	–	-150,000	–	-0.03%	–
TWST	Exit	TWIST BIOSCIENCE CORP	$0	–	-18,473	–	-0.03%	–
DNAY	Exit	CODEX DNA INC	$0	–	-200,000	–	-0.03%	–
CVRX	Exit	CVRX INC	$0	–	-150,000	–	-0.04%	–
MSAC	Exit	MEDICUS SCIENCES ACQUISITION	$0	–	-300,000	–	-0.04%	–
	Exit	SEMA4 HOLDINGS CORP	$0	–	-400,000	–	-0.04%	–
MAAC	Exit	MONTES ARCHIMEDES ACQUISITIO	$0	–	-400,000	–	-0.05%	–
	Exit	MAXCYTE INC	$0	–	-275,000	–	-0.05%	–
PNT	Exit	POINT BIOPHARMA GLOBAL INC	$0	–	-490,000	–	-0.06%	–
FVAM	Exit	5 01 ACQUISITION CORP	$0	–	-392,000	–	-0.06%	–
AFIB	Exit	ACUTUS MED INC	$0	–	-491,834	–	-0.07%	–
APVO	Exit	APTEVO THERAPEUTICS INC	$0	–	-281,402	–	-0.07%	–
IMTX	Exit	IMMATICS N.V	$0	–	-350,000	–	-0.07%	–
	Exit	ARYA SCIENCES ACQUISITN CORP	$0	–	-500,000	–	-0.07%	–
RCEL	Exit	AVITA MEDICAL INC	$0	–	-280,000	–	-0.08%	–
ARYD	Exit	ARYA SCIENCES ACQU CORP IVcl a	$0	–	-500,000	–	-0.08%	–
SMIHU	Exit	SUMMIT HEALTHCRE ACQUISTN COunit 06/03/2026	$0	–	-500,000	–	-0.08%	–
BLI	Exit	BERKELEY LTS INC	$0	–	-257,546	–	-0.08%	–
	Exit	SOPHIA GENETICS SAordinary shares	$0	–	-300,000	–	-0.08%	–
SRRK	Exit	SCHOLAR ROCK HLDG CORP	$0	–	-161,612	–	-0.08%	–
ASLN	Exit	ASLAN PHARMACEUTICALS LTDads	$0	–	-3,250,000	–	-0.09%	–
BLSA	Exit	BCLS ACQUISITION CORP	$0	–	-612,500	–	-0.09%	–
RACB	Exit	RESEARCH ALLIANCE CORP II	$0	–	-637,000	–	-0.10%	–
NAUT	Exit	NAUTILUS BIOTECHNOLOGY INC	$0	–	-1,100,000	–	-0.10%	–
CTMX	Exit	CYTOMX THERAPEUTICS INC	$0	–	-1,400,939	–	-0.11%	–
HLXA	Exit	HELIX ACQUISITION CORP	$0	–	-750,000	–	-0.11%	–
	Exit	PROCEPT BIOROBOTICS CORP	$0	–	-194,136	–	-0.11%	–
	Exit	TANGO THERAPEUTICS INC	$0	–	-600,000	–	-0.12%	–
LJPC	Exit	LA JOLLA PHARMACEUTICAL CO	$0	–	-2,327,903	–	-0.14%	–
LSAQ	Exit	LIFESCI ACQUISITION II CORP	$0	–	-975,000	–	-0.14%	–
BMEA	Exit	BIOMEA FUSION INC	$0	–	-830,794	–	-0.15%	–
	Exit	NYXOAH S A	$0	–	-344,911	–	-0.15%	–
JNCE	Exit	JOUNCE THERAPEUTICS INC	$0	–	-1,396,203	–	-0.16%	–
CNTB	Exit	CONNECT BIOPHARMA HLDGS LTDads	$0	–	-450,000	–	-0.16%	–
XGN	Exit	EXAGEN INC	$0	–	-821,414	–	-0.17%	–
VINC	Exit	VINCERX PHARMA INC	$0	–	-749,999	–	-0.18%	–
IMUX	Exit	IMMUNIC INC	$0	–	-1,370,814	–	-0.18%	–
BWAY	Exit	BRAINSWAY LTDsponsored ads	$0	–	-1,602,381	–	-0.20%	–
OSUR	Exit	ORASURE TECHNOLOGIES INC	$0	–	-1,174,722	–	-0.20%	–
URGN	Exit	UROGEN PHARMA LTD	$0	–	-857,464	–	-0.22%	–
NEO	Exit	NEOGENOMICS INC	$0	–	-311,111	–	-0.22%	–
ADVM	Exit	ADVERUM BIOTECHNOLOGIES INC	$0	–	-7,483,757	–	-0.24%	–
ATHA	Exit	ATHIRA PHARMA INC	$0	–	-1,906,557	–	-0.27%	–
TELA	Exit	TELA BIO INC	$0	–	-1,391,619	–	-0.29%	–
	Exit	RENOVACOR INC	$0	–	-2,187,540	–	-0.29%	–
CERE	Exit	CEREVEL THERAPEUTICS HLDNG I	$0	–	-666,666	–	-0.30%	–
INMD	Exit	INMODE LTD	$0	–	-124,999	–	-0.30%	–
ABUS	Exit	ARBUTUS BIOPHARMA CORP	$0	–	-4,733,323	–	-0.31%	–
EPIX	Exit	ESSA PHARMA INC	$0	–	-2,637,192	–	-0.32%	–
	Exit	AADI BIOSCIENCES INC	$0	–	-764,701	–	-0.32%	–
OYST	Exit	OYSTER PT PHARMA INC	$0	–	-1,861,209	–	-0.33%	–
GTH	Exit	GENETRON HLDGS LTDads	$0	–	-1,671,894	–	-0.35%	–
PMVP	Exit	PMV PHARMACEUTICALS INC	$0	–	-809,863	–	-0.36%	–
MIST	Exit	MILESTONE PHARMACEUTICALS IN	$0	–	-4,315,102	–	-0.37%	–
CLSD	Exit	CLEARSIDE BIOMEDICAL INC	$0	–	-4,206,765	–	-0.38%	–
GLUE	Exit	MONTE ROSA THERAPEUTICS INC	$0	–	-1,214,572	–	-0.39%	–
JNJ	Exit	JOHNSON & JOHNSON	$0	–	-170,542	–	-0.42%	–
	Exit	SIGHT SCIENCES INC	$0	–	-1,283,871	–	-0.44%	–
BLU	Exit	BELLUS HEALTH INC NEW	$0	–	-4,968,017	–	-0.46%	–
PTGX	Exit	PROTAGONIST THERAPEUTICS INC	$0	–	-1,753,695	–	-0.47%	–
OLK	Exit	OLINK HLDG ABsponsored ads	$0	–	-1,318,188	–	-0.48%	–
NSTG	Exit	NANOSTRING TECHNOLOGIES INC	$0	–	-804,029	–	-0.58%	–
CSTL	Exit	CASTLE BIOSCIENCES INC	$0	–	-599,009	–	-0.60%	–
RLMD	Exit	RELMADA THERAPEUTICS INC	$0	–	-1,538,026	–	-0.61%	–
LUNG	Exit	PULMONX CORP	$0	–	-1,164,600	–	-0.63%	–
ARGX	Exit	ARGENX SEsponsored adr	$0	–	-140,311	–	-0.64%	–
TARS	Exit	TARSUS PHARMACEUTICALS INC	$0	–	-2,013,601	–	-0.65%	–
OM	Exit	OUTSET MED INC	$0	–	-894,652	–	-0.67%	–
GHRS	Exit	GH RESEARCH PLCordinary shares	$0	–	-2,168,957	–	-0.69%	–
IMCR	Exit	IMMUNOCORE HLDGS PLCads	$0	–	-1,245,532	–	-0.70%	–
APYX	Exit	APYX MEDICAL CORPORATION	$0	–	-3,398,279	–	-0.71%	–
AGEN	Exit	AGENUS INC	$0	–	-9,074,438	–	-0.72%	–
	Exit	TENAYA THERAPEUTICS INC	$0	–	-2,458,750	–	-0.73%	–
AXSM	Exit	AXSOME THERAPEUTICS INC	$0	–	-1,616,497	–	-0.80%	–
PRQR	Exit	PROQR THRAPEUTICS N V	$0	–	-6,443,113	–	-0.81%	–
AVDL	Exit	AVADEL PHARMACEUTICALS PLCsponsored adr	$0	–	-5,741,939	–	-0.85%	–
CUTR	Exit	CUTERA INC	$0	–	-1,257,862	–	-0.88%	–
LABP	Exit	LANDOS BIOPHARMA INC	$0	–	-4,275,722	–	-0.94%	–
ITOS	Exit	ITEOS THERAPEUTICS INC	$0	–	-2,353,015	–	-0.96%	–
CYTK	Exit	CYTOKINETICS INC	$0	–	-2,000,000	–	-1.08%	–
RXDX	Exit	PROMETHEUS BIOSCIENCES INC	$0	–	-3,264,031	–	-1.17%	–
RGNX	Exit	REGENXBIO INC	$0	–	-1,845,366	–	-1.17%	–
MGNX	Exit	MACROGENICS INC	$0	–	-3,975,554	–	-1.26%	–
IDYA	Exit	IDEAYA BIOSCIENCES INC	$0	–	-3,266,255	–	-1.26%	–
STOK	Exit	STOKE THERAPEUTICS INC	$0	–	-3,644,248	–	-1.40%	–
	Exit	DERMTECH INC	$0	–	-3,118,665	–	-1.51%	–
PEN	Exit	PENUMBRA INC	$0	–	-385,194	–	-1.55%	–
TXG	Exit	10X GENOMICS INC	$0	–	-734,481	–	-1.61%	–
FULC	Exit	FULCRUM THERAPEUTICS INC	$0	–	-3,855,291	–	-1.64%	–
ISEE	Exit	IVERIC BIO INC	$0	–	-6,722,624	–	-1.65%	–
CCCC	Exit	C4 THERAPEUTICS INC	$0	–	-2,494,965	–	-1.68%	–
GH	Exit	GUARDANT HEALTH INC	$0	–	-925,342	–	-1.74%	–
RNA	Exit	AVIDITY BIOSCIENCES INC	$0	–	-4,795,000	–	-1.78%	–
AXNX	Exit	AXONICS INC	$0	–	-1,943,864	–	-1.91%	–
GMED	Exit	GLOBUS MED INCcl a	$0	–	-1,670,811	–	-1.93%	–
TNDM	Exit	TANDEM DIABETES CARE INC	$0	–	-1,160,734	–	-2.09%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-7,582,396	–	-2.30%	–
ESTA	Exit	ESTABLISHMENT LABS HLDGS INC	$0	–	-2,319,138	–	-2.50%	–
ILMN	Exit	ILLUMINA INC	$0	–	-482,791	–	-2.95%	–
PTCT	Exit	PTC THERAPEUTICS INC	$0	–	-5,293,966	–	-2.97%	–
NTRA	Exit	NATERA INC	$0	–	-1,862,234	–	-3.13%	–
CLDX	Exit	CELLDEX THERAPEUTICS INC NEW	$0	–	-3,908,947	–	-3.18%	–
VCEL	Exit	VERICEL CORP	$0	–	-4,517,570	–	-3.32%	–
MASI	Exit	MASIMO CORP	$0	–	-832,540	–	-3.40%	–
TMO	Exit	THERMO FISHER SCIENTIFIC INC	$0	–	-416,000	–	-3.58%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-1,492,532	–	-3.98%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INC	$0	–	-1,683,362	–	-4.79%	–
SPY	Exit	SPDR S&P 500 ETF TRtr unit	$0	–	-873,255	–	-5.65%	–
RCKT	Exit	ROCKET PHARMACEUTICALS INC	$0	–	-15,802,802	–	-7.08%	–

Q3 2021

			Value		Shares		↓ Weighting
RCKT	Buy	ROCKET PHARMACEUTICALS INC	$469,601,000	-29.3%	15,802,802	+5.4%	7.08%	-29.3%
SPY	Sell	SPDR S&P 500 ETF TRtr unit	$374,749,000	-12.1%	873,255	-12.3%	5.65%	-12.2%
MRTX	Buy	MIRATI THERAPEUTICS INC	$264,044,000	+12.2%	1,492,532	+2.4%	3.98%	+12.1%
TMO	New	THERMO FISHER SCIENTIFIC INC	$237,673,000	–	416,000	–	3.58%	–
MASI	Buy	MASIMO CORP	$225,377,000	+12.5%	832,540	+0.8%	3.40%	+12.4%
NTRA	Buy	NATERA INC	$207,527,000	+6.8%	1,862,234	+8.8%	3.13%	+6.7%
DRNA	Buy	DICERNA PHARMACEUTICALS INC	$152,861,000	-45.5%	7,582,396	+0.8%	2.30%	-45.6%
TNDM	Buy	TANDEM DIABETES CARE INC	$138,568,000	+24.0%	1,160,734	+1.2%	2.09%	+24.0%
RNA	Buy	AVIDITY BIOSCIENCES INC	$118,101,000	+19.6%	4,795,000	+20.0%	1.78%	+19.5%
GH	Buy	GUARDANT HEALTH INC	$115,677,000	+1.4%	925,342	+0.8%	1.74%	+1.4%
CCCC	Buy	C4 THERAPEUTICS INC	$111,475,000	+37.1%	2,494,965	+16.1%	1.68%	+37.0%
FULC	Buy	FULCRUM THERAPEUTICS INC	$108,758,000	+223.8%	3,855,291	+20.3%	1.64%	+223.5%
PEN	New	PENUMBRA INC	$102,654,000	–	385,194	–	1.55%	–
MGNX	Buy	MACROGENICS INC	$83,248,000	+21.7%	3,975,554	+56.1%	1.26%	+21.6%
RGNX	Buy	REGENXBIO INC	$77,358,000	+13.3%	1,845,366	+5.0%	1.17%	+13.3%
ITOS	Buy	ITEOS THERAPEUTICS INC	$63,531,000	+44.3%	2,353,015	+37.1%	0.96%	+44.3%
CUTR	Buy	CUTERA INC	$58,616,000	+65.9%	1,257,862	+74.5%	0.88%	+65.9%
	New	TENAYA THERAPEUTICS INC	$48,581,000	–	2,458,750	–	0.73%	–
AGEN	Sell	AGENUS INC	$47,641,000	-24.1%	9,074,438	-20.7%	0.72%	-24.2%
APYX	Buy	APYX MEDICAL CORPORATION	$47,066,000	+34.6%	3,398,279	+0.2%	0.71%	+34.5%
OM	Buy	OUTSET MED INC	$44,232,000	+20.1%	894,652	+21.4%	0.67%	+20.0%
ARGX	Buy	ARGENX SEsponsored adr	$42,374,000	+343.2%	140,311	+341.9%	0.64%	+343.8%
LUNG	Buy	PULMONX CORP	$41,902,000	-15.9%	1,164,600	+3.1%	0.63%	-16.0%
CSTL	Sell	CASTLE BIOSCIENCES INC	$39,834,000	-32.0%	599,009	-25.0%	0.60%	-32.0%
OLK	Buy	OLINK HLDG ABsponsored ads	$31,966,000	-25.6%	1,318,188	+5.6%	0.48%	-25.6%
PTGX	Sell	PROTAGONIST THERAPEUTICS INC	$31,075,000	-80.3%	1,753,695	-50.0%	0.47%	-80.3%
	New	SIGHT SCIENCES INC	$29,144,000	–	1,283,871	–	0.44%	–
PMVP	Buy	PMV PHARMACEUTICALS INC	$24,134,000	+45.9%	809,863	+67.3%	0.36%	+45.6%
GTH	Sell	GENETRON HLDGS LTDads	$23,156,000	-36.8%	1,671,894	-8.0%	0.35%	-36.9%
	New	AADI BIOSCIENCES INC	$21,336,000	–	764,701	–	0.32%	–
EPIX	Sell	ESSA PHARMA INC	$21,098,000	-75.8%	2,637,192	-13.6%	0.32%	-75.9%
ABUS	Sell	ARBUTUS BIOPHARMA CORP	$20,306,000	+12.1%	4,733,323	-20.8%	0.31%	+12.1%
CERE	Buy	CEREVEL THERAPEUTICS HLDNG I	$19,667,000	+53.5%	666,666	+33.3%	0.30%	+53.9%
	New	RENOVACOR INC	$19,254,000	–	2,187,540	–	0.29%	–
TELA	Sell	TELA BIO INC	$19,010,000	-15.3%	1,391,619	-0.1%	0.29%	-15.1%
ADVM	Buy	ADVERUM BIOTECHNOLOGIES INC	$16,240,000	-36.9%	7,483,757	+1.7%	0.24%	-37.0%
URGN	New	UROGEN PHARMA LTD	$14,423,000	–	857,464	–	0.22%	–
OSUR	New	ORASURE TECHNOLOGIES INC	$13,286,000	–	1,174,722	–	0.20%	–
BWAY	Buy	BRAINSWAY LTDsponsored ads	$12,915,000	-21.0%	1,602,381	+0.0%	0.20%	-21.1%
IMUX	Buy	IMMUNIC INC	$12,132,000	+7.5%	1,370,814	+48.9%	0.18%	+7.6%
JNCE	New	JOUNCE THERAPEUTICS INC	$10,374,000	–	1,396,203	–	0.16%	–
	New	NYXOAH S A	$10,087,000	–	344,911	–	0.15%	–
	New	TANGO THERAPEUTICS INC	$7,758,000	–	600,000	–	0.12%	–
	New	PROCEPT BIOROBOTICS CORP	$7,406,000	–	194,136	–	0.11%	–
	New	SOPHIA GENETICS SAordinary shares	$5,259,000	–	300,000	–	0.08%	–
	New	ARYA SCIENCES ACQUISITN CORP	$4,940,000	–	500,000	–	0.07%	–
AFIB	Buy	ACUTUS MED INC	$4,348,000	-43.3%	491,834	+8.9%	0.07%	-43.1%
PNT	New	POINT BIOPHARMA GLOBAL INC	$3,768,000	–	490,000	–	0.06%	–
	New	MAXCYTE INC	$3,358,000	–	275,000	–	0.05%	–
MAAC	New	MONTES ARCHIMEDES ACQUISITIO	$3,160,000	–	400,000	–	0.05%	–
	New	SEMA4 HOLDINGS CORP	$2,936,000	–	400,000	–	0.04%	–
	New	RXSIGHT INC	$1,901,000	–	150,000	–	0.03%	–
MDXG	Sell	MIMEDX GROUP INC	$1,792,000	-94.7%	295,748	-89.0%	0.03%	-94.7%
	New	RENOVACOR INC*w exp 99/99/999	$224,000	–	350,000	–	0.00%	–
PROG	Exit	PROGENITY INC	$0	–	-100,000	–	-0.01%	–
AZYO	Exit	AZIYO BIOLOGICS INC	$0	–	-125,000	–	-0.02%	–
BDSX	Exit	BIODESIX INC	$0	–	-125,000	–	-0.02%	–
CEREW	Exit	CEREVEL THERAPEUTICS HLDNG I*w exp 06/09/202	$0	–	-166,666	–	-0.04%	–
MRVI	Exit	MARAVAI LIFESCIENCES HLDGS I	$0	–	-70,000	–	-0.04%	–
PSNL	Exit	PERSONALIS INC	$0	–	-127,501	–	-0.05%	–
CHAQU	Exit	CHARDAN HEALTHCR ACQSTN 2 COunit 99/99/9999	$0	–	-350,000	–	-0.06%	–
RACA	Exit	THERAPEUTICS ACQUISITION COR	$0	–	-490,000	–	-0.08%	–
ITMR	Exit	ITAMAR MED LTDsponsored ads	$0	–	-268,609	–	-0.10%	–
BCTG	Exit	BCTG ACQUISITION CORP	$0	–	-600,000	–	-0.10%	–
CHAQ	Exit	CHARDAN HEALTHCR ACQSTN 2 CO	$0	–	-837,540	–	-0.12%	–
	Exit	TRILLIUM THERAPEUTICS INC	$0	–	-2,091,389	–	-0.31%	–
QDEL	Exit	QUIDEL CORP	$0	–	-878,533	–	-1.70%	–

Q2 2021

			Value		Shares		↓ Weighting
RCKT	New	ROCKET PHARMACEUTICALS INC	$663,920,000	–	14,990,286	–	10.02%	–
SPY	New	SPDR S&P 500 ETF TRtr unit	$426,457,000	–	996,255	–	6.44%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$285,364,000	–	1,683,362	–	4.31%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$280,716,000	–	7,521,859	–	4.24%	–
VCEL	New	VERICEL CORP	$237,172,000	–	4,517,570	–	3.58%	–
MRTX	New	MIRATI THERAPEUTICS INC	$235,435,000	–	1,457,532	–	3.55%	–
ILMN	New	ILLUMINA INC	$228,462,000	–	482,791	–	3.45%	–
PTCT	New	PTC THERAPEUTICS INC	$223,776,000	–	5,293,966	–	3.38%	–
ESTA	New	ESTABLISHMENT LABS HLDGS INC	$202,554,000	–	2,319,138	–	3.06%	–
MASI	New	MASIMO CORP	$200,315,000	–	826,210	–	3.02%	–
NTRA	New	NATERA INC	$194,390,000	–	1,712,234	–	2.93%	–
PTGX	New	PROTAGONIST THERAPEUTICS INC	$157,412,000	–	3,507,390	–	2.38%	–
TXG	New	10X GENOMICS INC	$143,826,000	–	734,481	–	2.17%	–
CLDX	New	CELLDEX THERAPEUTICS INC NEW	$130,715,000	–	3,908,947	–	1.97%	–
	New	DERMTECH INC	$129,643,000	–	3,118,665	–	1.96%	–
GMED	New	GLOBUS MED INCcl a	$129,538,000	–	1,670,811	–	1.96%	–
AXNX	New	AXONICS INC	$123,260,000	–	1,943,864	–	1.86%	–
STOK	New	STOKE THERAPEUTICS INC	$122,665,000	–	3,644,248	–	1.85%	–
GH	New	GUARDANT HEALTH INC	$114,038,000	–	918,253	–	1.72%	–
QDEL	New	QUIDEL CORP	$112,558,000	–	878,533	–	1.70%	–
TNDM	New	TANDEM DIABETES CARE INC	$111,758,000	–	1,147,408	–	1.69%	–
AXSM	New	AXSOME THERAPEUTICS INC	$109,049,000	–	1,616,497	–	1.65%	–
RNA	New	AVIDITY BIOSCIENCES INC	$98,716,000	–	3,995,000	–	1.49%	–
EPIX	New	ESSA PHARMA INC	$87,250,000	–	3,053,919	–	1.32%	–
CCCC	New	C4 THERAPEUTICS INC	$81,327,000	–	2,149,228	–	1.23%	–
RXDX	New	PROMETHEUS BIOSCIENCES INC	$75,989,000	–	3,264,031	–	1.15%	–
IDYA	New	IDEAYA BIOSCIENCES INC	$68,559,000	–	3,266,255	–	1.04%	–
MGNX	New	MACROGENICS INC	$68,410,000	–	2,546,925	–	1.03%	–
RGNX	New	REGENXBIO INC	$68,288,000	–	1,757,743	–	1.03%	–
AGEN	New	AGENUS INC	$62,790,000	–	11,437,238	–	0.95%	–
CSTL	New	CASTLE BIOSCIENCES INC	$58,591,000	–	799,009	–	0.88%	–
TARS	New	TARSUS PHARMACEUTICALS INC	$58,354,000	–	2,013,601	–	0.88%	–
NSTG	New	NANOSTRING TECHNOLOGIES INC	$52,093,000	–	804,029	–	0.79%	–
LUNG	New	PULMONX CORP	$49,838,000	–	1,129,600	–	0.75%	–
RLMD	New	RELMADA THERAPEUTICS INC	$49,232,000	–	1,538,026	–	0.74%	–
LABP	New	LANDOS BIOPHARMA INC	$48,457,000	–	4,275,722	–	0.73%	–
IMCR	New	IMMUNOCORE HLDGS PLCads	$47,888,000	–	1,245,532	–	0.72%	–
ITOS	New	ITEOS THERAPEUTICS INC	$44,030,000	–	1,716,585	–	0.66%	–
PRQR	New	PROQR THRAPEUTICS N V	$43,427,000	–	6,443,113	–	0.66%	–
OLK	New	OLINK HLDG ABsponsored ads	$42,963,000	–	1,248,188	–	0.65%	–
GHRS	New	GH RESEARCH PLCordinary shares	$42,661,000	–	2,168,957	–	0.64%	–
ISEE	New	IVERIC BIO INC	$42,420,000	–	6,722,624	–	0.64%	–
CYTK	New	CYTOKINETICS INC	$39,580,000	–	2,000,000	–	0.60%	–
AVDL	New	AVADEL PHARMACEUTICALS PLCsponsored adr	$38,643,000	–	5,741,939	–	0.58%	–
OM	New	OUTSET MED INC	$36,843,000	–	737,152	–	0.56%	–
GTH	New	GENETRON HLDGS LTDads	$36,618,000	–	1,818,162	–	0.55%	–
CUTR	New	CUTERA INC	$35,342,000	–	720,817	–	0.53%	–
APYX	New	APYX MEDICAL CORPORATION	$34,964,000	–	3,391,279	–	0.53%	–
MDXG	New	MIMEDX GROUP INC	$33,781,000	–	2,700,320	–	0.51%	–
FULC	New	FULCRUM THERAPEUTICS INC	$33,591,000	–	3,205,291	–	0.51%	–
OYST	New	OYSTER PT PHARMA INC	$31,994,000	–	1,861,209	–	0.48%	–
JNJ	New	JOHNSON & JOHNSON	$28,095,000	–	170,542	–	0.42%	–
ADVM	New	ADVERUM BIOTECHNOLOGIES INC	$25,753,000	–	7,357,917	–	0.39%	–
GLUE	New	MONTE ROSA THERAPEUTICS INC	$25,228,000	–	1,214,572	–	0.38%	–
MIST	New	MILESTONE PHARMACEUTICALS IN	$23,733,000	–	4,315,102	–	0.36%	–
TELA	New	TELA BIO INC	$22,432,000	–	1,392,434	–	0.34%	–
CLSD	New	CLEARSIDE BIOMEDICAL INC	$20,487,000	–	4,206,765	–	0.31%	–
	New	TRILLIUM THERAPEUTICS INC	$20,286,000	–	2,091,389	–	0.31%	–
ATHA	New	ATHIRA PHARMA INC	$19,523,000	–	1,906,557	–	0.30%	–
ABUS	New	ARBUTUS BIOPHARMA CORP	$18,114,000	–	5,978,355	–	0.27%	–
PMVP	New	PMV PHARMACEUTICALS INC	$16,538,000	–	484,133	–	0.25%	–
BWAY	New	BRAINSWAY LTDsponsored ads	$16,342,000	–	1,602,181	–	0.25%	–
BLU	New	BELLUS HEALTH INC NEW	$15,441,000	–	4,968,017	–	0.23%	–
NEO	New	NEOGENOMICS INC	$13,139,000	–	311,111	–	0.20%	–
CERE	New	CEREVEL THERAPEUTICS HLDNG I	$12,810,000	–	500,000	–	0.19%	–
XGN	New	EXAGEN INC	$12,313,000	–	821,414	–	0.19%	–
BMEA	New	BIOMEA FUSION INC	$12,270,000	–	830,794	–	0.18%	–
INMD	New	INMODE LTD	$11,835,000	–	124,999	–	0.18%	–
BLI	New	BERKELEY LTS INC	$11,541,000	–	257,546	–	0.17%	–
IMUX	New	IMMUNIC INC	$11,289,000	–	920,814	–	0.17%	–
ASLN	New	ASLAN PHARMACEUTICALS LTDads	$10,725,000	–	3,250,000	–	0.16%	–
NAUT	New	NAUTILUS BIOTECHNOLOGY INC	$10,383,000	–	1,100,000	–	0.16%	–
LJPC	New	LA JOLLA PHARMACEUTICAL CO	$9,963,000	–	2,327,903	–	0.15%	–
VINC	New	VINCERX PHARMA INC	$9,742,000	–	749,999	–	0.15%	–
LSAQ	New	LIFESCI ACQUISITION II CORP	$9,750,000	–	975,000	–	0.15%	–
ARGX	New	ARGENX SEsponsored adr	$9,560,000	–	31,752	–	0.14%	–
CTMX	New	CYTOMX THERAPEUTICS INC	$8,868,000	–	1,400,939	–	0.13%	–
CNTB	New	CONNECT BIOPHARMA HLDGS LTDads	$8,789,000	–	450,000	–	0.13%	–
CHAQ	New	CHARDAN HEALTHCR ACQSTN 2 CO	$8,299,000	–	837,540	–	0.12%	–
HLXA	New	HELIX ACQUISITION CORP	$7,763,000	–	750,000	–	0.12%	–
AFIB	New	ACUTUS MED INC	$7,672,000	–	451,834	–	0.12%	–
BCTG	New	BCTG ACQUISITION CORP	$6,828,000	–	600,000	–	0.10%	–
RACB	New	RESEARCH ALLIANCE CORP II	$6,459,000	–	637,000	–	0.10%	–
BLSA	New	BCLS ACQUISITION CORP	$6,450,000	–	612,500	–	0.10%	–
APVO	New	APTEVO THERAPEUTICS INC	$6,312,000	–	281,402	–	0.10%	–
ITMR	New	ITAMAR MED LTDsponsored ads	$6,326,000	–	268,609	–	0.10%	–
RCEL	New	AVITA MEDICAL INC	$5,746,000	–	280,000	–	0.09%	–
ARYD	New	ARYA SCIENCES ACQU CORP IVcl a	$5,360,000	–	500,000	–	0.08%	–
SMIHU	New	SUMMIT HEALTHCRE ACQUISTN COunit 06/03/2026	$5,005,000	–	500,000	–	0.08%	–
RACA	New	THERAPEUTICS ACQUISITION COR	$5,034,000	–	490,000	–	0.08%	–
SRRK	New	SCHOLAR ROCK HLDG CORP	$4,671,000	–	161,612	–	0.07%	–
DNAY	New	CODEX DNA INC	$4,400,000	–	200,000	–	0.07%	–
CVRX	New	CVRX INC	$4,200,000	–	150,000	–	0.06%	–
IMTX	New	IMMATICS N.V	$4,064,000	–	350,000	–	0.06%	–
FVAM	New	5 01 ACQUISITION CORP	$3,908,000	–	392,000	–	0.06%	–
CHAQU	New	CHARDAN HEALTHCR ACQSTN 2 COunit 99/99/9999	$3,644,000	–	350,000	–	0.06%	–
MIRO	New	MIROMATRIX MED INC	$3,262,000	–	280,000	–	0.05%	–
PSNL	New	PERSONALIS INC	$3,226,000	–	127,501	–	0.05%	–
MRVI	New	MARAVAI LIFESCIENCES HLDGS I	$2,921,000	–	70,000	–	0.04%	–
MSAC	New	MEDICUS SCIENCES ACQUISITION	$2,895,000	–	300,000	–	0.04%	–
ZY	New	ZYMERGEN INC	$2,801,000	–	70,000	–	0.04%	–
OMIC	New	SINGULAR GENOMICS SYSTEMS IN	$2,748,000	–	100,000	–	0.04%	–
TWST	New	TWIST BIOSCIENCE CORP	$2,462,000	–	18,473	–	0.04%	–
CEREW	New	CEREVEL THERAPEUTICS HLDNG I*w exp 06/09/202	$2,398,000	–	166,666	–	0.04%	–
PROF	New	PROFOUND MED CORP	$1,998,000	–	122,098	–	0.03%	–
BOLT	New	BOLT BIOTHERAPEUTICS INC	$1,954,000	–	126,365	–	0.03%	–
AKYA	New	AKOYA BIOSCIENCES INC	$1,934,000	–	100,000	–	0.03%	–
BDSX	New	BIODESIX INC	$1,651,000	–	125,000	–	0.02%	–
MASS	New	908 DEVICES INC	$1,550,000	–	40,000	–	0.02%	–
AZYO	New	AZIYO BIOLOGICS INC	$1,201,000	–	125,000	–	0.02%	–
BNR	New	BURNING ROCK BIOTECH LTDsponsored ads	$884,000	–	30,000	–	0.01%	–
PROG	New	PROGENITY INC	$357,000	–	100,000	–	0.01%	–
MSACW	New	MEDICUS SCIENCES ACQUISITION*w exp 02/12/202	$34,000	–	33,331	–	0.00%	–

Q4 2020

			Value		Shares		↓ Weighting
PHGEWS	Exit	BiomX Equities Warrant Exp 13 Dec 2023*w exp 10/16/202	$0	–	-600,000	–	-0.01%	–
BNR	Exit	Burning Rock Biotech Ltdsponsored ads	$0	–	-30,000	–	-0.02%	–
TWST	Exit	Twist Bioscience Corp	$0	–	-18,473	–	-0.03%	–
PROG	Exit	Progenity Inc	$0	–	-275,000	–	-0.06%	–
CHAQU	Exit	Chardan Healthcare Acquisition 2 Corpunit 99/99/9999	$0	–	-350,000	–	-0.09%	–
PANAU	Exit	Panacea Acquisition Corpunit 99/99/9999	$0	–	-300,000	–	-0.09%	–
IMTX	Exit	Immatics Nv	$0	–	-350,000	–	-0.09%	–
PHGE	Exit	Biomx Inc	$0	–	-600,000	–	-0.09%	–
PROF	Exit	Profound Medical Corp	$0	–	-244,193	–	-0.10%	–
ARYA	Exit	Arya Sciences Acquisition Corp	$0	–	-500,000	–	-0.13%	–
ARYBU	Exit	Arya Sciences Acquisition II Corpunit 06/09/2027	$0	–	-500,000	–	-0.13%	–
PSNL	Exit	Personalis Inc	$0	–	-255,000	–	-0.13%	–
EQ	Exit	Equillium Inc	$0	–	-1,004,784	–	-0.14%	–
QURE	Exit	Uniqure NV	$0	–	-158,479	–	-0.14%	–
CLSD	Exit	Clearside Biomedical Inc	$0	–	-3,947,518	–	-0.15%	–
BCTG	Exit	BCTG Acquisition Corp	$0	–	-600,000	–	-0.15%	–
BWAY	Exit	Brainsway Ltdsponsored ads	$0	–	-1,107,420	–	-0.16%	–
LSACU	Exit	Lifesci Acquisition Corpunit 03/31/2025	$0	–	-500,000	–	-0.16%	–
TMDX	Exit	Transmedics Group Inc	$0	–	-503,266	–	-0.17%	–
RACA	Exit	Therapeutics Acquisition Corp	$0	–	-490,000	–	-0.17%	–
ARGX	Exit	argenx SEsponsored adr	$0	–	-31,752	–	-0.20%	–
RGNX	Exit	Regenxbio Inc	$0	–	-318,434	–	-0.21%	–
INMD	Exit	Inmode Ltd	$0	–	-250,000	–	-0.22%	–
FULC	Exit	Fulcrum Therapeutics Inc	$0	–	-1,150,565	–	-0.22%	–
ITMR	Exit	Itamar Medical Ltdsponsored ads	$0	–	-457,218	–	-0.22%	–
BLU	Exit	Bellus Health Inc	$0	–	-4,195,356	–	-0.23%	–
LJPC	Exit	La Jolla Pharmaceutical Co	$0	–	-2,395,029	–	-0.23%	–
CTMX	Exit	Cytomx Therapeutics Inc	$0	–	-1,526,003	–	-0.24%	–
ARCT	Exit	Arcturus Therapeutics Ltd	$0	–	-251,236	–	-0.26%	–
GNMK	Exit	GenMark Diagnostics Inc	$0	–	-762,994	–	-0.26%	–
ODT	Exit	Odonate Therapeutics Inc	$0	–	-999,256	–	-0.32%	–
AFIB	Exit	Acutus Medical Inc	$0	–	-451,834	–	-0.32%	–
XGN	Exit	Exagen Inc	$0	–	-1,250,131	–	-0.33%	–
AMRS	Exit	Amyris Inc	$0	–	-5,161,347	–	-0.36%	–
APYX	Exit	Apyx Medical Corp	$0	–	-3,391,279	–	-0.38%	–
IMUX	Exit	Immunic Inc	$0	–	-912,496	–	-0.41%	–
MDXG	Exit	MiMedx Group Inc	$0	–	-2,700,320	–	-0.41%	–
ALT	Exit	Altimmune Inc	$0	–	-1,334,940	–	-0.42%	–
PMVP	Exit	Pmv Pharmaceuticals Inc	$0	–	-500,000	–	-0.43%	–
ABUS	Exit	Arbutus Biopharma Corp	$0	–	-5,978,355	–	-0.45%	–
OM	Exit	Outset Medical Inc	$0	–	-405,000	–	-0.49%	–
ITOS	Exit	Iteos Therapeutics Inc	$0	–	-902,855	–	-0.50%	–
ADAP	Exit	Adaptimmune Therapeutics PLCsponds adr	$0	–	-2,617,626	–	-0.50%	–
JNJ	Exit	Johnson & Johnson	$0	–	-149,761	–	-0.54%	–
TELA	Exit	Tela Bio Inc	$0	–	-1,378,776	–	-0.55%	–
BLI	Exit	Berkeley Lights Inc	$0	–	-300,338	–	-0.55%	–
VXRT	Exit	Vaxart Inc	$0	–	-3,517,345	–	-0.56%	–
PRQR	Exit	ProQR Therapeutics NV	$0	–	-4,973,174	–	-0.57%	–
OSUR	Exit	OraSure Technologies Inc	$0	–	-2,075,082	–	-0.61%	–
FIXX	Exit	Homology Medicines Inc	$0	–	-2,517,906	–	-0.65%	–
AVDL	Exit	Avadel Pharmaceuticals plcsponsored adr	$0	–	-5,366,705	–	-0.65%	–
INCY	Exit	Incyte Corp	$0	–	-334,144	–	-0.72%	–
	Exit	Trillium Therapeutics Inc	$0	–	-2,160,800	–	-0.74%	–
MIST	Exit	Milestone Pharmaceuticals Inc	$0	–	-4,315,102	–	-0.76%	–
MGNX	Exit	MacroGenics Inc	$0	–	-1,255,299	–	-0.76%	–
	Exit	DermTech Inc	$0	–	-2,887,215	–	-0.83%	–
ISEE	Exit	IVERIC bio Inc	$0	–	-6,663,439	–	-0.90%	–
CSTL	Exit	Castle Biosciences Inc	$0	–	-743,642	–	-0.92%	–
OYST	Exit	Oyster Point Pharma Inc	$0	–	-1,923,893	–	-0.98%	–
CYTK	Exit	Cytokinetics Inc Private	$0	–	-2,000,000	–	-0.98%	–
NSTG	Exit	NanoString Technologies Inc	$0	–	-947,134	–	-1.02%	–
ESTA	Exit	Establishment Labs Holdings Inc	$0	–	-2,319,138	–	-1.04%	–
ATHA	Exit	Athira Pharma Inc	$0	–	-2,668,913	–	-1.09%	–
CLDX	Exit	Celldex Therapeutics Inc	$0	–	-3,120,137	–	-1.11%	–
FREQ	Exit	Frequency Therapeutics Inc	$0	–	-2,461,486	–	-1.14%	–
TBIO	Exit	Translate Bio Inc	$0	–	-3,745,286	–	-1.23%	–
AGEN	Exit	Agenus Inc	$0	–	-12,864,677	–	-1.24%	–
GH	Exit	Guardant Health Inc	$0	–	-469,498	–	-1.26%	–
ILMN	Exit	Illumina Inc	$0	–	-175,000	–	-1.30%	–
RLMD	Exit	Relmada Therapeutics Inc	$0	–	-1,511,337	–	-1.37%	–
PTGX	Exit	Protagonist Therapeutics Inc	$0	–	-3,408,961	–	-1.60%	–
TNDM	Exit	Tandem Diabetes Care Inc	$0	–	-603,481	–	-1.65%	–
VCEL	Exit	Vericel Corp	$0	–	-3,850,851	–	-1.72%	–
ADVM	Exit	Adverum Biotechnologies Inc	$0	–	-7,234,764	–	-1.79%	–
TXG	Exit	10x Genomics Inc	$0	–	-660,933	–	-1.98%	–
BAX	Exit	Baxter International Inc	$0	–	-1,077,268	–	-2.09%	–
AXNX	Exit	Axonics Modulation Technologies Inc	$0	–	-1,883,864	–	-2.32%	–
CERN	Exit	Cerner Corp	$0	–	-1,392,049	–	-2.42%	–
MASI	Exit	Masimo Corp	$0	–	-450,390	–	-2.56%	–
RNA	Exit	Avidity Biosciences Inc	$0	–	-3,995,000	–	-2.65%	–
STOK	Exit	Stoke Therapeutics Inc	$0	–	-3,544,248	–	-2.86%	–
AXSM	Exit	Axsome Therapeutics Inc	$0	–	-1,670,938	–	-2.87%	–
NTRA	Exit	Natera Inc	$0	–	-1,710,769	–	-2.98%	–
MYOK	Exit	Myokardia Inc	$0	–	-936,931	–	-3.08%	–
DRNA	Exit	Dicerna Pharmaceuticals Inc	$0	–	-7,227,413	–	-3.13%	–
MRTX	Exit	Mirati Therapeutics Inc	$0	–	-1,096,005	–	-4.38%	–
PTCT	Exit	PTC Therapeutics Inc	$0	–	-3,993,286	–	-4.50%	–
ALNY	Exit	Alnylam Pharmaceuticals Inc	$0	–	-1,681,645	–	-5.90%	–
IMVT	Exit	Immunovant Inc	$0	–	-7,510,412	–	-6.36%	–
RCKT	Exit	Rocket Pharmaceuticals Inc	$0	–	-16,812,491	–	-9.25%	–

Q3 2020

			Value		Shares		↓ Weighting
IMVT	Buy	Immunovant Inc	$264,291,000	+89.8%	7,510,412	+31.4%	6.36%	+62.5%
PTCT	Buy	PTC Therapeutics Inc	$186,686,000	-7.2%	3,993,286	+0.8%	4.50%	-20.5%
MRTX	Buy	Mirati Therapeutics Inc	$181,992,000	+46.5%	1,096,005	+0.8%	4.38%	+25.4%
DRNA	Buy	Dicerna Pharmaceuticals Inc	$130,021,000	-28.4%	7,227,413	+1.0%	3.13%	-38.8%
NTRA	Buy	Natera Inc	$123,586,000	+62.1%	1,710,769	+11.9%	2.98%	+38.7%
AXSM	Buy	Axsome Therapeutics Inc	$119,054,000	-12.7%	1,670,938	+0.8%	2.87%	-25.3%
MASI	Buy	Masimo Corp	$106,319,000	+19.9%	450,390	+15.8%	2.56%	+2.6%
CERN	Buy	Cerner Corp	$100,631,000	+24.2%	1,392,049	+17.7%	2.42%	+6.3%
AXNX	Buy	Axonics Modulation Technologies Inc	$96,152,000	+45.4%	1,883,864	+0.0%	2.32%	+24.5%
BAX	Buy	Baxter International Inc	$86,634,000	+3.8%	1,077,268	+11.1%	2.09%	-11.2%
TXG	Buy	10x Genomics Inc	$82,405,000	+45.1%	660,933	+3.9%	1.98%	+24.2%
ADVM	Buy	Adverum Biotechnologies Inc	$74,518,000	-47.4%	7,234,764	+6.5%	1.79%	-55.0%
VCEL	Buy	Vericel Corp	$71,356,000	+34.1%	3,850,851	+0.0%	1.72%	+14.8%
TNDM	Buy	Tandem Diabetes Care Inc	$68,495,000	+15.6%	603,481	+0.8%	1.65%	-1.1%
PTGX	Buy	Protagonist Therapeutics Inc	$66,645,000	+11.5%	3,408,961	+0.8%	1.60%	-4.5%
RLMD	Buy	Relmada Therapeutics Inc	$56,857,000	-14.2%	1,511,337	+2.1%	1.37%	-26.6%
ILMN	New	Illumina Inc	$54,089,000	–	175,000	–	1.30%	–
GH	New	Guardant Health Inc	$52,480,000	–	469,498	–	1.26%	–
TBIO	Buy	Translate Bio Inc	$50,973,000	-23.5%	3,745,286	+0.8%	1.23%	-34.5%
FREQ	Buy	Frequency Therapeutics Inc	$47,285,000	-5.9%	2,461,486	+13.9%	1.14%	-19.5%
CLDX	Buy	Celldex Therapeutics Inc	$46,272,000	+36.4%	3,120,137	+19.5%	1.11%	+16.6%
ATHA	New	Athira Pharma Inc	$45,372,000	–	2,668,913	–	1.09%	–
CYTK	New	Cytokinetics Inc Private	$40,702,000	–	2,000,000	–	0.98%	–
OYST	Buy	Oyster Point Pharma Inc	$40,613,000	-26.3%	1,923,893	+0.8%	0.98%	-36.9%
CSTL	Sell	Castle Biosciences Inc	$38,260,000	+26.3%	743,642	-7.5%	0.92%	+8.1%
ISEE	Buy	IVERIC bio Inc	$37,582,000	+11.7%	6,663,439	+1.0%	0.90%	-4.3%
	Buy	DermTech Inc	$34,502,000	-8.7%	2,887,215	+1.1%	0.83%	-21.8%
MGNX	Buy	MacroGenics Inc	$31,621,000	-9.1%	1,255,299	+0.8%	0.76%	-22.3%
	New	Trillium Therapeutics Inc	$30,705,000	–	2,160,800	–	0.74%	–
INCY	New	Incyte Corp	$29,986,000	–	334,144	–	0.72%	–
AVDL	Buy	Avadel Pharmaceuticals plcsponsored adr	$27,048,000	-36.9%	5,366,705	+1.1%	0.65%	-46.0%
FIXX	Sell	Homology Medicines Inc	$26,942,000	-59.2%	2,517,906	-42.1%	0.65%	-65.1%
OSUR	Buy	OraSure Technologies Inc	$25,254,000	+40.9%	2,075,082	+34.7%	0.61%	+20.6%
PRQR	Buy	ProQR Therapeutics NV	$23,822,000	-20.1%	4,973,174	+1.4%	0.57%	-31.6%
VXRT	New	Vaxart Inc	$23,390,000	–	3,517,345	–	0.56%	–
BLI	New	Berkeley Lights Inc	$22,934,000	–	300,338	–	0.55%	–
TELA	Buy	Tela Bio Inc	$22,805,000	+29.0%	1,378,776	+1.1%	0.55%	+10.5%
JNJ	Buy	Johnson & Johnson	$22,296,000	+25.0%	149,761	+18.1%	0.54%	+7.0%
ITOS	New	Iteos Therapeutics Inc	$20,904,000	–	902,855	–	0.50%	–
ADAP	Buy	Adaptimmune Therapeutics PLCsponds adr	$20,889,000	-19.7%	2,617,626	+0.7%	0.50%	-31.3%
OM	New	Outset Medical Inc	$20,250,000	–	405,000	–	0.49%	–
ABUS	Sell	Arbutus Biopharma Corp	$18,712,000	+49.7%	5,978,355	-13.0%	0.45%	+28.1%
PMVP	New	Pmv Pharmaceuticals Inc	$17,750,000	–	500,000	–	0.43%	–
ALT	New	Altimmune Inc	$17,621,000	–	1,334,940	–	0.42%	–
IMUX	New	Immunic Inc	$16,945,000	–	912,496	–	0.41%	–
AMRS	Buy	Amyris Inc	$15,071,000	+21.5%	5,161,347	+66.3%	0.36%	+4.0%
XGN	Sell	Exagen Inc	$13,551,000	-13.0%	1,250,131	-0.4%	0.33%	-25.6%
AFIB	New	Acutus Medical Inc	$13,465,000	–	451,834	–	0.32%	–
ODT	Buy	Odonate Therapeutics Inc	$13,420,000	-34.1%	999,256	+107.7%	0.32%	-43.6%
GNMK	Sell	GenMark Diagnostics Inc	$10,835,000	-21.2%	762,994	-18.4%	0.26%	-32.6%
ARCT	New	Arcturus Therapeutics Ltd	$10,778,000	–	251,236	–	0.26%	–
CTMX	Buy	Cytomx Therapeutics Inc	$10,148,000	-19.6%	1,526,003	+0.8%	0.24%	-31.3%
LJPC	Buy	La Jolla Pharmaceutical Co	$9,652,000	-4.6%	2,395,029	+0.8%	0.23%	-18.6%
BLU	Sell	Bellus Health Inc	$9,547,000	-84.5%	4,195,356	-29.7%	0.23%	-86.7%
FULC	New	Fulcrum Therapeutics Inc	$9,124,000	–	1,150,565	–	0.22%	–
RGNX	Buy	Regenxbio Inc	$8,763,000	-24.7%	318,434	+0.8%	0.21%	-35.5%
RACA	New	Therapeutics Acquisition Corp	$7,046,000	–	490,000	–	0.17%	–
BCTG	New	BCTG Acquisition Corp	$6,216,000	–	600,000	–	0.15%	–
CLSD	Buy	Clearside Biomedical Inc	$6,079,000	-17.5%	3,947,518	+0.8%	0.15%	-29.5%
QURE	Buy	Uniqure NV	$5,837,000	-17.6%	158,479	+0.8%	0.14%	-29.1%
EQ	New	Equillium Inc	$5,798,000	–	1,004,784	–	0.14%	–
ARYA	New	Arya Sciences Acquisition Corp	$5,408,000	–	500,000	–	0.13%	–
PROF	Buy	Profound Medical Corp	$4,308,000	+46.0%	244,193	+40.2%	0.10%	+25.3%
IMTX	New	Immatics Nv	$3,714,000	–	350,000	–	0.09%	–
PANAU	New	Panacea Acquisition Corpunit 99/99/9999	$3,600,000	–	300,000	–	0.09%	–
VRAY	Exit	Viewray Inc	$0	–	-150,000	–	-0.01%	–
MOTS	Exit	Motus Gi Hldgs Inc	$0	–	-775,640	–	-0.03%	–
FLGT	Exit	Fulgent Genetics Inc	$0	–	-75,000	–	-0.03%	–
NARI	Exit	Inari Med Inc	$0	–	-44,860	–	-0.06%	–
ARVN	Exit	Arvinas Inc	$0	–	-174,118	–	-0.16%	–
RPTX	Exit	Repare Therapeutics Inc	$0	–	-225,000	–	-0.20%	–
NEO	Exit	Neogenomics Inc	$0	–	-445,000	–	-0.39%	–
STAA	Exit	STAAR Surgical Co	$0	–	-308,904	–	-0.54%	–
WVE	Exit	WAVE Life Sciences Ltd	$0	–	-2,390,496	–	-0.70%	–

Q2 2020

			Value		Shares		↓ Weighting
RCKT	New	Rocket Pharmaceuticals Inc	$351,885,000	–	16,812,491	–	9.90%	–
ALNY	New	Alnylam Pharmaceuticals Inc	$249,068,000	–	1,681,645	–	7.01%	–
PTCT	New	PTC Therapeutics Inc	$201,089,000	–	3,963,120	–	5.66%	–
DRNA	New	Dicerna Pharmaceuticals Inc	$181,684,000	–	7,152,918	–	5.11%	–
ADVM	New	Adverum Biotechnologies Inc	$141,776,000	–	6,790,027	–	3.99%	–
IMVT	New	Immunovant Inc	$139,213,000	–	5,717,182	–	3.92%	–
AXSM	New	Axsome Therapeutics Inc	$136,446,000	–	1,658,316	–	3.84%	–
MRTX	New	Mirati Therapeutics Inc	$124,186,000	–	1,087,726	–	3.49%	–
RNA	New	Avidity Biosciences Inc	$103,863,000	–	3,995,000	–	2.92%	–
MYOK	New	Myokardia Inc	$90,526,000	–	936,931	–	2.55%	–
MASI	New	Masimo Corp	$88,637,000	–	388,776	–	2.49%	–
STOK	New	Stoke Therapeutics Inc	$84,459,000	–	3,544,248	–	2.38%	–
BAX	New	Baxter Intl Inc	$83,463,000	–	969,370	–	2.35%	–
CERN	New	Cerner Corp	$81,054,000	–	1,182,409	–	2.28%	–
NTRA	New	Natera Inc	$76,242,000	–	1,529,128	–	2.14%	–
TBIO	New	Translate Bio Inc	$66,609,000	–	3,716,994	–	1.87%	–
RLMD	New	Relmada Therapeutics Inc	$66,268,000	–	1,480,852	–	1.86%	–
AXNX	New	Axonics Modulation Technolog	$66,121,000	–	1,883,257	–	1.86%	–
FIXX	New	Homology Medicines Inc	$66,110,000	–	4,352,190	–	1.86%	–
BLU	New	Bellus Health Inc New	$61,550,000	–	5,970,230	–	1.73%	–
PTGX	New	Protagonist Therapeutics Inc	$59,747,000	–	3,383,208	–	1.68%	–
TNDM	New	Tandem Diabetes Care Inc	$59,245,000	–	598,923	–	1.67%	–
TXG	New	10x Genomics Inc	$56,809,000	–	636,092	–	1.60%	–
OYST	New	Oyster Pt Pharma Inc	$55,142,000	–	1,909,360	–	1.55%	–
VCEL	New	Vericel Corp	$53,212,000	–	3,850,347	–	1.50%	–
AGEN	New	Agenus Inc	$50,558,000	–	12,864,677	–	1.42%	–
FREQ	New	Frequency Therapeutics Inc	$50,255,000	–	2,161,486	–	1.41%	–
ESTA	New	Establishment Labs Hldgs Inc	$43,322,000	–	2,319,138	–	1.22%	–
AVDL	New	Avadel Pharmaceuticals plcsponsored adr	$42,877,000	–	5,306,570	–	1.21%	–
	New	DermTech Inc	$37,782,000	–	2,855,765	–	1.06%	–
MGNX	New	MacroGenics Inc	$34,783,000	–	1,245,816	–	0.98%	–
CLDX	New	Celldex Therapeutics Inc New	$33,930,000	–	2,610,000	–	0.96%	–
ISEE	New	IVERIC bio Inc	$33,642,000	–	6,596,536	–	0.95%	–
CSTL	New	Castle Biosciences Inc	$30,284,000	–	803,510	–	0.85%	–
PRQR	New	ProQR Thrapeutics N V	$29,809,000	–	4,902,785	–	0.84%	–
NSTG	New	NanoString Technologies Inc	$27,798,000	–	947,134	–	0.78%	–
ADAP	New	Adaptimmune Therapeutics PLCsponds adr	$26,026,000	–	2,600,000	–	0.73%	–
WVE	New	WAVE Life Sciences Ltd	$24,885,000	–	2,390,496	–	0.70%	–
ODT	New	Odonate Therapeutics Inc	$20,367,000	–	481,027	–	0.57%	–
STAA	New	STAAR Surgical Co	$19,010,000	–	308,904	–	0.54%	–
APYX	New	Apyx Med Corp	$18,822,000	–	3,391,279	–	0.53%	–
OSUR	New	OraSure Technologies Inc	$17,922,000	–	1,540,972	–	0.50%	–
JNJ	New	Johnson & Johnson	$17,840,000	–	126,858	–	0.50%	–
TELA	New	Tela Bio Inc	$17,682,000	–	1,364,358	–	0.50%	–
MIST	New	Milestone Pharmaceuticals In	$16,311,000	–	4,315,102	–	0.46%	–
XGN	New	Exagen Inc	$15,576,000	–	1,255,131	–	0.44%	–
MDXG	New	MiMedx Group Inc	$14,582,000	–	2,700,320	–	0.41%	–
NEO	New	Neogenomics Inc	$13,786,000	–	445,000	–	0.39%	–
GNMK	New	GenMark Diagnostics Inc	$13,757,000	–	935,206	–	0.39%	–
CTMX	New	Cytomx Therapeutics Inc	$12,616,000	–	1,514,476	–	0.36%	–
ABUS	New	Arbutus Biopharma Corp	$12,502,000	–	6,869,281	–	0.35%	–
AMRS	New	Amyris Inc	$12,401,000	–	3,103,535	–	0.35%	–
RGNX	New	Regenxbio Inc	$11,639,000	–	316,028	–	0.33%	–
LJPC	New	La Jolla Pharmaceutical Co	$10,117,000	–	2,374,952	–	0.28%	–
TMDX	New	Transmedics Group Inc	$9,019,000	–	503,266	–	0.25%	–
ITMR	New	Itamar Med Ltdsponsored ads	$8,504,000	–	457,218	–	0.24%	–
CLSD	New	Clearside Biomedical Inc	$7,365,000	–	3,917,622	–	0.21%	–
ARGX	New	argenx SEsponsored adr	$7,152,000	–	31,752	–	0.20%	–
QURE	New	Uniqure NV	$7,087,000	–	157,282	–	0.20%	–
INMD	New	Inmode Ltd	$7,080,000	–	250,000	–	0.20%	–
RPTX	New	Repare Therapeutics Inc	$6,980,000	–	225,000	–	0.20%	–
BWAY	New	Brainsway Ltdsponsored ads	$6,556,000	–	1,107,420	–	0.18%	–
ARVN	New	Arvinas Inc	$5,840,000	–	174,118	–	0.16%	–
ARYBU	New	ARYA Sciences Acquistion Counit 06/09/2027	$5,798,000	–	500,000	–	0.16%	–
LSACU	New	Lifesci Acquisition Corpunit 03/31/2025	$5,500,000	–	500,000	–	0.16%	–
CHAQU	New	Chardan Healthcr Acqstn 2 Counit 99/99/9999	$3,675,000	–	350,000	–	0.10%	–
PHGE	New	Biomx Inc	$3,312,000	–	600,000	–	0.09%	–
PSNL	New	Personalis Inc	$3,307,000	–	255,000	–	0.09%	–
PROF	New	Profound Med Corp	$2,951,000	–	174,193	–	0.08%	–
PROG	New	Progenity Inc	$2,475,000	–	275,000	–	0.07%	–
NARI	New	Inari Med Inc	$2,173,000	–	44,860	–	0.06%	–
FLGT	New	Fulgent Genetics Inc	$1,200,000	–	75,000	–	0.03%	–
MOTS	New	Motus Gi Hldgs Inc	$1,024,000	–	775,640	–	0.03%	–
TWST	New	Twist Bioscience Corp	$837,000	–	18,473	–	0.02%	–
BNR	New	Burning Rock Biotech Ltdsponsored ads	$810,000	–	30,000	–	0.02%	–
VRAY	New	Viewray Inc	$336,000	–	150,000	–	0.01%	–
PHGEWS	New	BiomX Inc*w exp 10/16/202	$287,000	–	600,000	–	0.01%	–

Q4 2019

			Value		Shares		↓ Weighting
TXG	Exit	10x Genomics Inc	$0	–	-5,000	–	-0.02%	–
LVGO	Exit	Livongo Health Inc	$0	–	-15,000	–	-0.02%	–
OPTN	Exit	Optinose Inc	$0	–	-87,805	–	-0.04%	–
MOTS	Exit	Motus Gi Hldgs Inc	$0	–	-675,640	–	-0.08%	–
STIM	Exit	Neuronetics Inc	$0	–	-167,728	–	-0.08%	–
SLDB	Exit	Solid Biosciences Inc	$0	–	-145,541	–	-0.09%	–
CLSD	Exit	Clearside Biomedical Inc	$0	–	-3,747,699	–	-0.14%	–
	Exit	Vivus Inc 4.5 05/01/2020note 4.500% 5/0	$0	–	-4,000,000	–	-0.17%	–
CDNA	Exit	CareDx Inc	$0	–	-154,951	–	-0.21%	–
ARGX	Exit	argenx SEsponsored adr	$0	–	-31,516	–	-0.21%	–
PSNL	Exit	Personalis Inc	$0	–	-255,000	–	-0.22%	–
SNSS	Exit	Sunesis Pharmaceuticals Inc	$0	–	-6,946,074	–	-0.30%	–
INMD	Exit	Inmode Ltd	$0	–	-250,000	–	-0.32%	–
QURE	Exit	Uniqure NV	$0	–	-144,909	–	-0.34%	–
CHACU	Exit	Chardan Healthcare Acquisitiunit 12/13/2023	$0	–	-600,000	–	-0.43%	–
CTMX	Exit	Cytomx Therapeutics Inc	$0	–	-990,463	–	-0.44%	–
BWAY	Exit	Brainsway Ltdsponsored ads	$0	–	-834,687	–	-0.45%	–
PRNB	Exit	Principia Biopharma Inc	$0	–	-270,948	–	-0.46%	–
XGN	Exit	Exagen Inc	$0	–	-511,633	–	-0.47%	–
SILK	Exit	Silk Road Medical Inc	$0	–	-244,716	–	-0.47%	–
ABUS	Exit	Arbutus Biopharma Corp	$0	–	-5,562,967	–	-0.50%	–
ODT	Exit	Odonate Therapeutics Inc	$0	–	-339,892	–	-0.53%	–
PTGX	Exit	Protagonist Therapeutics Inc	$0	–	-762,283	–	-0.54%	–
NTRA	Exit	Natera Inc	$0	–	-287,470	–	-0.56%	–
FLDM	Exit	Fluidigm Corp Del	$0	–	-2,109,500	–	-0.58%	–
QTNT	Exit	Quotient Ltd	$0	–	-1,281,143	–	-0.59%	–
RGNX	Exit	Regenxbio Inc	$0	–	-291,168	–	-0.62%	–
QDEL	Exit	Quidel Corp	$0	–	-176,495	–	-0.64%	–
TMDX	Exit	Transmedics Group Inc	$0	–	-503,266	–	-0.71%	–
	Exit	DermTech Inc	$0	–	-2,386,871	–	-0.74%	–
CSTL	Exit	Castle Biosciences Inc	$0	–	-745,045	–	-0.80%	–
MDXG	Exit	MiMedx Group Inc	$0	–	-2,964,000	–	-0.86%	–
JNJ	Exit	Johnson & Johnson	$0	–	-116,858	–	-0.90%	–
AXSM	Exit	Axsome Therapeutics Inc	$0	–	-846,121	–	-1.02%	–
ARVN	Exit	Arvinas Inc	$0	–	-809,623	–	-1.04%	–
LJPC	Exit	La Jolla Pharmaceutical Co	$0	–	-2,016,269	–	-1.06%	–
PODD	Exit	Insulet Corp	$0	–	-111,232	–	-1.09%	–
PRQR	Exit	ProQR Thrapeutics N V	$0	–	-3,700,833	–	-1.27%	–
APYX	Exit	Apyx Med Corp	$0	–	-3,370,279	–	-1.36%	–
AGEN	Exit	Agenus Inc	$0	–	-9,213,191	–	-1.41%	–
BLU	Exit	Bellus Health Inc New	$0	–	-4,178,156	–	-1.60%	–
TBIO	Exit	Translate Bio Inc	$0	–	-3,148,628	–	-1.86%	–
ADVM	Exit	Adverum Biotechnologies Inc	$0	–	-6,281,003	–	-2.04%	–
MYOK	Exit	Myokardia Inc	$0	–	-725,025	–	-2.25%	–
ESTA	Exit	Establishment Labs Hldgs Inc	$0	–	-2,039,681	–	-2.29%	–
VCEL	Exit	Vericel Corp	$0	–	-2,645,476	–	-2.38%	–
AXNX	Exit	Axonics Modulation Tech Inc	$0	–	-1,534,605	–	-2.46%	–
FIXX	Exit	Homology Medicines Inc	$0	–	-2,449,478	–	-2.64%	–
MRTX	Exit	Mirati Therapeutics Inc	$0	–	-592,776	–	-2.75%	–
ACHN	Exit	Achillion Pharmaceuticals In	$0	–	-13,864,383	–	-2.97%	–
SRPT	Exit	Sarepta Therapeutics Inc	$0	–	-724,311	–	-3.24%	–
MASI	Exit	Masimo Corp	$0	–	-371,155	–	-3.28%	–
ZBH	Exit	Zimmer Biomet Hldgs Inc	$0	–	-403,000	–	-3.29%	–
MIST	Exit	Milestone Pharmaceuticals In	$0	–	-3,521,856	–	-3.80%	–
STOK	Exit	Stoke Therapeutics Inc	$0	–	-3,355,466	–	-4.13%	–
BMY	Exit	Bristol Myers Squibb Co	$0	–	-1,565,307	–	-4.72%	–
DRNA	Exit	Dicerna Pharmaceuticals Inc	$0	–	-6,202,425	–	-5.30%	–
PTCT	Exit	PTC Therapeutics Inc	$0	–	-3,651,361	–	-7.34%	–
ALNY	Exit	Alnylam Pharmaceuticals Inc	$0	–	-1,767,628	–	-8.45%	–
RCKT	Exit	Rocket Pharmaceuticals Inc	$0	–	-16,587,491	–	-11.45%	–

Q3 2019

			Value		Shares		↓ Weighting
ALNY	Sell	Alnylam Pharmaceuticals Inc	$142,153,000	-10.9%	1,767,628	-19.6%	8.45%	-0.8%
PTCT	Buy	PTC Therapeutics Inc	$123,489,000	-12.5%	3,651,361	+16.4%	7.34%	-2.6%
DRNA	Buy	Dicerna Pharmaceuticals Inc	$89,067,000	-8.1%	6,202,425	+0.8%	5.30%	+2.4%
BMY	Buy	Bristol Myers Squibb Co	$79,377,000	+12.1%	1,565,307	+0.2%	4.72%	+24.8%
ZBH	New	Zimmer Biomet Hldgs Inc	$55,320,000	–	403,000	–	3.29%	–
MASI	Sell	Masimo Corp	$55,224,000	-0.3%	371,155	-0.3%	3.28%	+11.0%
SRPT	Buy	Sarepta Therapeutics Inc	$54,555,000	-40.6%	724,311	+19.9%	3.24%	-33.8%
MRTX	Buy	Mirati Therapeutics Inc	$46,183,000	+75.6%	592,776	+132.2%	2.75%	+95.6%
FIXX	Buy	Homology Medicines Inc	$44,336,000	+10.2%	2,449,478	+19.2%	2.64%	+22.8%
VCEL	Buy	Vericel Corp	$40,053,000	-18.7%	2,645,476	+1.5%	2.38%	-9.4%
ESTA	Buy	Establishment Labs Hldgs Inc	$38,570,000	-6.9%	2,039,681	+8.3%	2.29%	+3.7%
MYOK	Buy	Myokardia Inc	$37,810,000	+4.2%	725,025	+0.2%	2.25%	+16.1%
ADVM	Sell	Adverum Biotechnologies Inc	$34,231,000	-54.4%	6,281,003	-0.6%	2.04%	-49.3%
TBIO	Buy	Translate Bio Inc	$31,203,000	+1.3%	3,148,628	+29.1%	1.86%	+12.8%
BLU	New	Bellus Health Inc New	$26,856,000	–	4,178,156	–	1.60%	–
AGEN	Sell	Agenus Inc	$23,770,000	-21.4%	9,213,191	-8.6%	1.41%	-12.5%
APYX	Sell	Apyx Med Corp	$22,817,000	-0.1%	3,370,279	-0.9%	1.36%	+11.2%
PRQR	Sell	ProQR Thrapeutics N V	$21,317,000	-37.1%	3,700,833	-0.6%	1.27%	-29.9%
PODD	New	Insulet Corp	$18,345,000	–	111,232	–	1.09%	–
LJPC	Buy	La Jolla Pharmaceutical Co	$17,743,000	-4.6%	2,016,269	+0.2%	1.06%	+6.1%
ARVN	Buy	Arvinas Inc	$17,447,000	-1.8%	809,623	+0.2%	1.04%	+9.4%
AXSM	Buy	Axsome Therapeutics Inc	$17,125,000	-21.2%	846,121	+0.2%	1.02%	-12.3%
JNJ	Buy	Johnson & Johnson	$15,119,000	+15.6%	116,858	+24.4%	0.90%	+28.6%
MDXG	New	MiMedx Group Inc	$14,524,000	–	2,964,000	–	0.86%	–
CSTL	New	Castle Biosciences Inc	$13,478,000	–	745,045	–	0.80%	–
	New	DermTech Inc	$12,498,000	–	2,386,871	–	0.74%	–
TMDX	Sell	Transmedics Group Inc	$11,953,000	-18.7%	503,266	-0.7%	0.71%	-9.4%
QDEL	New	Quidel Corp	$10,828,000	–	176,495	–	0.64%	–
RGNX	Sell	Regenxbio Inc	$10,366,000	-45.2%	291,168	-20.9%	0.62%	-39.0%
QTNT	Sell	Quotient Ltd	$9,954,000	-31.1%	1,281,143	-17.0%	0.59%	-23.2%
FLDM	Buy	Fluidigm Corp Del	$9,767,000	-61.8%	2,109,500	+1.5%	0.58%	-57.5%
NTRA	New	Natera Inc	$9,429,000	–	287,470	–	0.56%	–
PTGX	New	Protagonist Therapeutics Inc	$9,155,000	–	762,283	–	0.54%	–
ODT	Buy	Odonate Therapeutics Inc	$8,847,000	-28.9%	339,892	+0.2%	0.53%	-20.9%
ABUS	Buy	Arbutus Biopharma Corp	$8,484,000	-26.3%	5,562,967	+0.5%	0.50%	-17.9%
SILK	Buy	Silk Road Medical Inc	$7,961,000	-26.6%	244,716	+9.4%	0.47%	-18.3%
XGN	New	Exagen Inc	$7,925,000	–	511,633	–	0.47%	–
BWAY	Buy	Brainsway Ltdsponsored ads	$7,604,000	+21.4%	834,687	+39.8%	0.45%	+34.9%
CTMX	Buy	Cytomx Therapeutics Inc	$7,310,000	-34.1%	990,463	+0.2%	0.44%	-26.5%
QURE	Buy	Uniqure NV	$5,704,000	-49.5%	144,909	+0.2%	0.34%	-43.9%
INMD	New	Inmode Ltd	$5,378,000	–	250,000	–	0.32%	–
SNSS	New	Sunesis Pharmaceuticals Inc	$5,000,000	–	6,946,074	–	0.30%	–
PSNL	Buy	Personalis Inc	$3,742,000	-38.7%	255,000	+13.3%	0.22%	-31.6%
ARGX	Buy	argenx SEsponsored adr	$3,592,000	-19.3%	31,516	+0.2%	0.21%	-10.1%
CDNA	Buy	CareDx Inc	$3,503,000	-37.1%	154,951	+0.2%	0.21%	-30.0%
CLSD	New	Clearside Biomedical Inc	$2,361,000	–	3,747,699	–	0.14%	–
SLDB	Buy	Solid Biosciences Inc	$1,505,000	+80.2%	145,541	+0.2%	0.09%	+100.0%
STIM	Sell	Neuronetics Inc	$1,394,000	-33.8%	167,728	-0.3%	0.08%	-25.9%
MOTS	Sell	Motus Gi Hldgs Inc	$1,338,000	-60.8%	675,640	-40.0%	0.08%	-56.0%
OPTN	Buy	Optinose Inc	$615,000	-0.8%	87,805	+0.2%	0.04%	+12.1%
LVGO	New	Livongo Health Inc	$262,000	–	15,000	–	0.02%	–
TXG	New	10x Genomics Inc	$252,000	–	5,000	–	0.02%	–
ANCN	Exit	ANCHIANO THERAPEUTICS LTDsponsored ads	$0	–	-51,918	–	-0.01%	–
VRAY	Exit	VIEWRAY INC	$0	–	-159,247	–	-0.08%	–
VIVE	Exit	VIVEVE MED INC	$0	–	-4,480,565	–	-0.09%	–
MYGN	Exit	MYRIAD GENETICS INC	$0	–	-376,586	–	-0.56%	–
KIDS	Exit	ORTHOPEDIATRICS CORP	$0	–	-376,647	–	-0.78%	–
ARWR	Exit	ARROWHEAD PHARMACEUTICALS IN	$0	–	-1,120,346	–	-1.59%	–
ILMN	Exit	ILLUMINA INC	$0	–	-82,000	–	-1.61%	–

Q2 2019

			Value		Shares		↓ Weighting
RCKT	New	ROCKET PHARMACEUTICALS INC	$248,812,000	–	16,587,491	–	13.29%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$159,494,000	–	2,198,094	–	8.52%	–
PTCT	New	PTC THERAPEUTICS INC	$141,181,000	–	3,137,361	–	7.54%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$96,896,000	–	6,152,103	–	5.18%	–
STOK	New	STOKE THERAPEUTICS INC	$92,570,000	–	3,355,466	–	4.94%	–
SRPT	New	SAREPTA THERAPEUTICS INC	$91,814,000	–	604,236	–	4.90%	–
MIST	New	MILESTONE PHARMACEUTICALS IN	$90,967,000	–	3,521,856	–	4.86%	–
ADVM	New	ADVERUM BIOTECHNOLOGIES INC	$75,149,000	–	6,320,350	–	4.01%	–
BMY	New	BRISTOL MYERS SQUIBB CO	$70,833,000	–	1,561,918	–	3.78%	–
AXNX	New	AXONICS MODULATION TECH INC	$62,873,000	–	1,534,605	–	3.36%	–
MASI	New	MASIMO CORP	$55,399,000	–	372,258	–	2.96%	–
VCEL	New	VERICEL CORP	$49,242,000	–	2,606,771	–	2.63%	–
ESTA	New	ESTABLISHMENT LABS HLDGS INC	$41,411,000	–	1,883,180	–	2.21%	–
FIXX	New	HOMOLOGY MEDICINES INC	$40,215,000	–	2,054,932	–	2.15%	–
ACHN	New	ACHILLION PHARMACEUTICALS IN	$37,157,000	–	13,864,383	–	1.98%	–
MYOK	New	MYOKARDIA INC	$36,274,000	–	723,455	–	1.94%	–
PRQR	New	PROQR THRAPEUTICS N V	$33,879,000	–	3,722,950	–	1.81%	–
TBIO	New	TRANSLATE BIO INC	$30,808,000	–	2,439,250	–	1.64%	–
AGEN	New	AGENUS INC	$30,253,000	–	10,084,214	–	1.62%	–
ILMN	New	ILLUMINA INC	$30,188,000	–	82,000	–	1.61%	–
ARWR	New	ARROWHEAD PHARMACEUTICALS IN	$29,689,000	–	1,120,346	–	1.59%	–
MRTX	New	MIRATI THERAPEUTICS INC	$26,293,000	–	255,270	–	1.40%	–
FLDM	New	FLUIDIGM CORP DEL	$25,594,000	–	2,077,471	–	1.37%	–
APYX	New	APYX MED CORP	$22,847,000	–	3,399,899	–	1.22%	–
AXSM	New	AXSOME THERAPEUTICS INC	$21,740,000	–	844,289	–	1.16%	–
RGNX	New	REGENXBIO INC	$18,906,000	–	368,040	–	1.01%	–
LJPC	New	LA JOLLA PHARMACEUTICAL CO	$18,605,000	–	2,011,340	–	0.99%	–
ARVN	New	ARVINAS INC	$17,765,000	–	807,870	–	0.95%	–
KIDS	New	ORTHOPEDIATRICS CORP	$14,689,000	–	376,647	–	0.78%	–
TMDX	New	TRANSMEDICS GROUP INC	$14,698,000	–	507,007	–	0.78%	–
QTNT	New	QUOTIENT LTD	$14,437,000	–	1,544,047	–	0.77%	–
JNJ	New	JOHNSON & JOHNSON	$13,080,000	–	93,912	–	0.70%	–
ODT	New	ODONATE THERAPEUTICS INC	$12,444,000	–	339,156	–	0.66%	–
ABUS	New	ARBUTUS BIOPHARMA CORP	$11,509,000	–	5,533,093	–	0.62%	–
QURE	New	UNIQURE NV	$11,300,000	–	144,595	–	0.60%	–
CTMX	New	CYTOMX THERAPEUTICS INC	$11,089,000	–	988,319	–	0.59%	–
SILK	New	SILK ROAD MEDICAL INC	$10,842,000	–	223,722	–	0.58%	–
MYGN	New	MYRIAD GENETICS INC	$10,462,000	–	376,586	–	0.56%	–
PRNB	New	PRINCIPIA BIOPHARMA INC	$8,993,000	–	270,948	–	0.48%	–
BWAY	New	BRAINSWAY LTDsponsored ads	$6,263,000	–	597,216	–	0.34%	–
CHACU	New	CHARDAN HEALTHCARE ACQUISITIunit 12/13/2023	$6,113,000	–	600,000	–	0.33%	–
PSNL	New	PERSONALIS INC	$6,109,000	–	225,000	–	0.33%	–
CDNA	New	CAREDX INC	$5,565,000	–	154,616	–	0.30%	–
ARGX	New	ARGENX SEsponsored adr	$4,452,000	–	31,448	–	0.24%	–
MOTS	New	MOTUS GI HLDGS INC	$3,412,000	–	1,126,144	–	0.18%	–
	New	Vivus Inc 4.5 05/01/2020note 4.500% 5/0	$3,128,000	–	4,000,000	–	0.17%	–
STIM	New	NEURONETICS INC	$2,105,000	–	168,274	–	0.11%	–
VIVE	New	VIVEVE MED INC	$1,703,000	–	4,480,565	–	0.09%	–
VRAY	New	VIEWRAY INC	$1,403,000	–	159,247	–	0.08%	–
SLDB	New	SOLID BIOSCIENCES INC	$835,000	–	145,225	–	0.04%	–
OPTN	New	OPTINOSE INC	$620,000	–	87,615	–	0.03%	–
ANCN	New	ANCHIANO THERAPEUTICS LTDsponsored ads	$233,000	–	51,918	–	0.01%	–

Q4 2018

			Value		Shares		↓ Weighting
MOTS	Exit	MOTUS GI HLDGS INC	$0	–	-59,478	–	-0.02%	–
BLCM	Exit	Bellicum Pharmaceuticals Inc	$0	–	-157,489	–	-0.06%	–
ADVM	Exit	Adverum Biotechnologies Inc	$0	–	-184,821	–	-0.07%	–
NVUS	Exit	Novus Therapeutics Inc	$0	–	-316,257	–	-0.09%	–
TPIV	Exit	Tapimmune Inc	$0	–	-209,721	–	-0.11%	–
RMED	Exit	RA MED SYS INC	$0	–	-110,000	–	-0.12%	–
ARGX	Exit	ARGENX SEsponsored adr	$0	–	-26,853	–	-0.12%	–
PTI	Exit	PROTEOSTASIS THERAPEUTICS IN	$0	–	-1,129,121	–	-0.16%	–
	Exit	VIVUS INCnote 4.500% 5/0	$0	–	-4,000,000	–	-0.19%	–
STIM	Exit	Neuronetics Inc	$0	–	-157,487	–	-0.30%	–
NVAX	Exit	Novavax Inc	$0	–	-2,771,023	–	-0.31%	–
NVTRQ	Exit	Nuvectra Corp	$0	–	-251,329	–	-0.33%	–
ODT	Exit	Odonate Therapeutics Inc	$0	–	-289,608	–	-0.34%	–
ECOR	Exit	ELECTROCORE INC	$0	–	-514,165	–	-0.43%	–
VIVE	Exit	VIVEVE MED INC	$0	–	-3,147,232	–	-0.50%	–
VKTX	Exit	Viking Therapeutics Inc	$0	–	-500,000	–	-0.52%	–
FIXX	Exit	Homology Medicines Inc	$0	–	-434,917	–	-0.60%	–
CDNA	Exit	CareDx Inc	$0	–	-357,766	–	-0.62%	–
PACB	Exit	PACIFIC BIOSCIENCES CALIF IN	$0	–	-2,237,607	–	-0.72%	–
SLDB	Exit	Solid Biosciences Inc	$0	–	-262,318	–	-0.74%	–
QURE	Exit	Uniqure NV	$0	–	-428,980	–	-0.94%	–
BVX	Exit	Bovie Medical Corp	$0	–	-2,235,547	–	-0.95%	–
RMD	Exit	ResMed Inc	$0	–	-147,400	–	-1.02%	–
PRNB	Exit	Principia Biopharma Inc	$0	–	-644,448	–	-1.04%	–
MYOK	Exit	Myokardia Inc	$0	–	-273,917	–	-1.07%	–
ESTA	Exit	ESTABLISHMENT LABS HLDGS INC	$0	–	-775,809	–	-1.08%	–
AGEN	Exit	Agenus Inc	$0	–	-9,824,579	–	-1.26%	–
LJPC	Exit	La Jolla Pharmaceutical Co	$0	–	-1,197,107	–	-1.44%	–
QGEN	Exit	Qiagen NV	$0	–	-775,324	–	-1.76%	–
ILMN	Exit	Illumina Inc	$0	–	-82,621	–	-1.82%	–
VCEL	Exit	Vericel Corp	$0	–	-2,217,916	–	-1.88%	–
VRAY	Exit	Viewray Inc	$0	–	-3,389,498	–	-1.90%	–
ALNY	Exit	Alnylam Pharmaceuticals Inc	$0	–	-389,072	–	-2.04%	–
CORI	Exit	CORIUM INTL INC	$0	–	-3,610,632	–	-2.06%	–
ABUS	Exit	Arbutus Biopharma Corp	$0	–	-4,084,904	–	-2.31%	–
MASI	Exit	Masimo Corp	$0	–	-310,461	–	-2.32%	–
ACHN	Exit	ACHILLION PHARMACEUTICALS IN	$0	–	-13,595,704	–	-3.00%	–
SRPT	Exit	Sarepta Therapeutics Inc	$0	–	-314,070	–	-3.04%	–
LIVN	Exit	LivaNova PLC	$0	–	-443,036	–	-3.29%	–
BMY	Exit	BRISTOL MYERS SQUIBB CO	$0	–	-946,961	–	-3.52%	–
PRQR	Exit	PROQR THRAPEUTICS N V	$0	–	-3,739,406	–	-4.33%	–
DRNA	Exit	Dicerna Pharmaceuticals Inc	$0	–	-5,461,124	–	-4.99%	–
RGNX	Exit	Regenxbio Inc	$0	–	-1,459,128	–	-6.60%	–
ARWR	Exit	ARROWHEAD PHARMACEUTICALS IN	$0	–	-7,604,225	–	-8.73%	–
PTCT	Exit	PTC Therapeutics Inc	$0	–	-3,275,591	–	-9.22%	–
RCKT	Exit	Rocket Pharmaceuticals Inc	$0	–	-14,969,744	–	-22.07%	–

Q3 2018

			Value		Shares		↓ Weighting
PTCT	Sell	PTC Therapeutics Inc	$153,953,000	+12.0%	3,275,591	-19.6%	9.22%	-7.0%
ARWR	Sell	ARROWHEAD PHARMACEUTICALS IN	$145,773,000	+29.1%	7,604,225	-8.4%	8.73%	+7.2%
RGNX	Sell	Regenxbio Inc	$110,164,000	-26.2%	1,459,128	-29.8%	6.60%	-38.7%
DRNA	Buy	Dicerna Pharmaceuticals Inc	$83,337,000	+34.9%	5,461,124	+8.3%	4.99%	+12.0%
PRQR	New	PROQR THRAPEUTICS N V	$72,358,000	–	3,739,406	–	4.33%	–
BMY	Buy	BRISTOL MYERS SQUIBB CO	$58,787,000	+17.6%	946,961	+4.8%	3.52%	-2.4%
LIVN	Buy	LivaNova PLC	$54,923,000	+27.7%	443,036	+2.8%	3.29%	+6.0%
SRPT	Sell	Sarepta Therapeutics Inc	$50,725,000	-60.8%	314,070	-67.9%	3.04%	-67.4%
ACHN	Buy	ACHILLION PHARMACEUTICALS IN	$50,032,000	+30.6%	13,595,704	+0.4%	3.00%	+8.4%
MASI	Buy	Masimo Corp	$38,665,000	+58.7%	310,461	+24.4%	2.32%	+31.8%
ABUS	Sell	Arbutus Biopharma Corp	$38,602,000	+2.4%	4,084,904	-20.9%	2.31%	-15.0%
CORI	Buy	CORIUM INTL INC	$34,337,000	+122.9%	3,610,632	+87.7%	2.06%	+85.1%
ALNY	Buy	Alnylam Pharmaceuticals Inc	$34,052,000	-1.8%	389,072	+10.5%	2.04%	-18.5%
VRAY	Buy	Viewray Inc	$31,726,000	+211.0%	3,389,498	+129.9%	1.90%	+158.2%
ILMN	Buy	Illumina Inc	$30,327,000	+118.7%	82,621	+66.4%	1.82%	+81.6%
QGEN	Buy	Qiagen NV	$29,369,000	+53.4%	775,324	+46.5%	1.76%	+27.3%
LJPC	Sell	La Jolla Pharmaceutical Co	$24,098,000	-38.6%	1,197,107	-11.1%	1.44%	-49.0%
AGEN	Buy	Agenus Inc	$21,025,000	-1.2%	9,824,579	+4.8%	1.26%	-18.0%
ESTA	New	ESTABLISHMENT LABS HLDGS INC	$18,094,000	–	775,809	–	1.08%	–
MYOK	Buy	Myokardia Inc	$17,859,000	+37.6%	273,917	+4.8%	1.07%	+14.2%
PRNB	New	Principia Biopharma Inc	$17,369,000	–	644,448	–	1.04%	–
RMD	New	ResMed Inc	$17,001,000	–	147,400	–	1.02%	–
BVX	Buy	Bovie Medical Corp	$15,872,000	+75.2%	2,235,547	+7.4%	0.95%	+45.5%
QURE	Buy	Uniqure NV	$15,611,000	+0.9%	428,980	+4.8%	0.94%	-16.2%
SLDB	Sell	Solid Biosciences Inc	$12,376,000	-45.6%	262,318	-61.2%	0.74%	-54.8%
PACB	New	PACIFIC BIOSCIENCES CALIF IN	$12,105,000	–	2,237,607	–	0.72%	–
CDNA	Sell	CareDx Inc	$10,322,000	+10.3%	357,766	-53.2%	0.62%	-8.4%
FIXX	Buy	Homology Medicines Inc	$9,942,000	+115.2%	434,917	+92.1%	0.60%	+78.7%
VKTX	New	Viking Therapeutics Inc	$8,710,000	–	500,000	–	0.52%	–
VIVE	Buy	VIVEVE MED INC	$8,435,000	+8.4%	3,147,232	+10.0%	0.50%	-10.0%
ECOR	Buy	ELECTROCORE INC	$7,198,000	-13.7%	514,165	+1.8%	0.43%	-28.3%
ODT	Buy	Odonate Therapeutics Inc	$5,621,000	-7.9%	289,608	+4.8%	0.34%	-23.4%
NVTRQ	Sell	Nuvectra Corp	$5,524,000	-29.8%	251,329	-34.4%	0.33%	-41.6%
NVAX	Buy	Novavax Inc	$5,210,000	+47.1%	2,771,023	+4.8%	0.31%	+21.9%
STIM	Sell	Neuronetics Inc	$5,049,000	-0.1%	157,487	-17.1%	0.30%	-17.3%
	New	VIVUS INCnote 4.500% 5/0	$3,185,000	–	4,000,000	–	0.19%	–
PTI	Buy	PROTEOSTASIS THERAPEUTICS IN	$2,721,000	-9.5%	1,129,121	+4.8%	0.16%	-24.9%
ARGX	Buy	ARGENX SEsponsored adr	$2,037,000	-3.8%	26,853	+5.1%	0.12%	-20.3%
RMED	New	RA MED SYS INC	$2,002,000	–	110,000	–	0.12%	–
TPIV	Buy	Tapimmune Inc	$1,898,000	+0.6%	209,721	+4.9%	0.11%	-16.2%
NVUS	Buy	Novus Therapeutics Inc	$1,477,000	-30.1%	316,257	+4.8%	0.09%	-42.1%
ADVM	Buy	Adverum Biotechnologies Inc	$1,118,000	+19.6%	184,821	+4.8%	0.07%	0.0%
BLCM	Buy	Bellicum Pharmaceuticals Inc	$970,000	-12.5%	157,489	+4.8%	0.06%	-27.5%
	Exit	Vivus Inc 4.5 05/01/2020note 4.500% 5/0	$0	–	-4,000,000	–	-0.23%	–
PTE	Exit	Polarityte Inc	$0	–	-426,670	–	-0.72%	–

Q2 2018

			Value		Shares		↓ Weighting
RCKT	New	Rocket Pharmaceuticals Inc	$289,448,000	–	14,969,744	–	20.88%	–
RGNX	New	Regenxbio Inc	$149,208,000	–	2,079,555	–	10.76%	–
PTCT	New	Ptc Therapeutics Inc	$137,406,000	–	4,073,690	–	9.91%	–
SRPT	New	Sarepta Therapeutics Inc	$129,345,000	–	978,551	–	9.33%	–
ARWR	New	Arrowhead Pharmaceuticals In	$112,874,000	–	8,299,542	–	8.14%	–
DRNA	New	Dicerna Pharmaceuticals Inc	$61,799,000	–	5,044,813	–	4.46%	–
BMY	New	Bristol Myers Squibb Co	$50,009,000	–	903,672	–	3.61%	–
LIVN	New	Livanova PLC	$43,022,000	–	431,000	–	3.10%	–
LJPC	New	La Jolla Pharmaceutical Co	$39,259,000	–	1,345,881	–	2.83%	–
ACHN	New	Achillion Pharmaceuticals In	$38,324,000	–	13,541,997	–	2.76%	–
ABUS	New	Arbutus Biopharma Corp	$37,708,000	–	5,165,499	–	2.72%	–
ALNY	New	Alnylam Pharmaceuticals Inc	$34,688,000	–	352,200	–	2.50%	–
MASI	New	Masimo Corp	$24,368,000	–	249,543	–	1.76%	–
SLDB	New	Solid Biosciences Inc	$22,753,000	–	675,771	–	1.64%	–
VCEL	New	Vericel Corp	$21,514,000	–	2,217,916	–	1.55%	–
AGEN	New	Agenus Inc	$21,282,000	–	9,375,451	–	1.54%	–
QGEN	New	Qiagen NV	$19,143,000	–	529,385	–	1.38%	–
QURE	New	Uniqure NV	$15,474,000	–	409,370	–	1.12%	–
CORI	New	Corium Intl Inc	$15,405,000	–	1,923,217	–	1.11%	–
ILMN	New	Illumina Inc	$13,869,000	–	49,658	–	1.00%	–
MYOK	New	Myokardia Inc	$12,978,000	–	261,395	–	0.94%	–
VRAY	New	Viewray Inc	$10,201,000	–	1,474,156	–	0.74%	–
PTE	New	Polarityte Inc	$10,044,000	–	426,670	–	0.72%	–
CDNA	New	Caredx Inc	$9,358,000	–	764,532	–	0.68%	–
BVX	New	Bovie Medical Corp	$9,057,000	–	2,082,137	–	0.65%	–
ECOR	New	Electrocore Inc	$8,338,000	–	505,000	–	0.60%	–
NVTRQ	New	Nuvectra Corp	$7,864,000	–	383,030	–	0.57%	–
VIVE	New	Viveve Med Inc	$7,782,000	–	2,861,023	–	0.56%	–
ODT	New	Odonate Therapeutics Inc	$6,102,000	–	276,368	–	0.44%	–
STIM	New	Neuronetics Inc	$5,056,000	–	190,000	–	0.36%	–
FIXX	New	Homology Medicines Inc	$4,619,000	–	226,431	–	0.33%	–
NVAX	New	Novavax Inc	$3,543,000	–	2,644,346	–	0.26%	–
	New	Vivus Inc 4.5 05/01/2020note 4.500% 5/0	$3,140,000	–	4,000,000	–	0.23%	–
PTI	New	Proteostasis Therapeutics In	$3,006,000	–	1,077,408	–	0.22%	–
ARGX	New	Argenx Sesponsored adr	$2,118,000	–	25,559	–	0.15%	–
NVUS	New	Novus Therapeutics Inc	$2,113,000	–	301,799	–	0.15%	–
TPIV	New	Tapimmune Inc	$1,886,000	–	200,000	–	0.14%	–
BLCM	New	Bellicum Pharmaceuticals Inc	$1,109,000	–	150,289	–	0.08%	–
ADVM	New	Adverum Biotechnologies Inc	$935,000	–	176,372	–	0.07%	–
MOTS	New	Motus Gi Hldgs Inc	$428,000	–	59,478	–	0.03%	–

Q4 2017

			Value		Shares		↓ Weighting
SRTSW	Exit	SENSUS HEATLHCARE INC*w exp 06/08/201	$0	–	-155,000	–	-0.02%	–
ARGX	Exit	argenx SEsponsored adr	$0	–	-24,906	–	-0.10%	–
GBT	Exit	Global Blood Therapeutics In	$0	–	-26,310	–	-0.14%	–
ZYNE	Exit	Zynerba Pharmaceuticals Inc	$0	–	-200,000	–	-0.29%	–
BVX	Exit	Bovie Medical Corp	$0	–	-1,139,600	–	-0.67%	–
SBPH	Exit	Spring Bk Pharmaceuticals In	$0	–	-249,095	–	-0.73%	–
VRAY	Exit	Viewray Inc	$0	–	-1,020,462	–	-1.02%	–
VIVE	Exit	Viveve Med Inc	$0	–	-1,473,028	–	-1.34%	–
MASI	Exit	Masimo Corp	$0	–	-120,900	–	-1.82%	–
ATRA	Exit	Atara Biotherapeutics Inc	$0	–	-656,018	–	-1.89%	–
MYOK	Exit	Myokardia Inc	$0	–	-253,962	–	-1.90%	–
TCMD	Exit	Tactile Sys Technology Inc	$0	–	-353,216	–	-1.90%	–
DRNA	Exit	Dicerna Pharmaceuticals Inc	$0	–	-2,078,991	–	-2.08%	–
OSUR	Exit	OraSure Technologies Inc	$0	–	-535,707	–	-2.10%	–
BLUE	Exit	bluebird bio Inc	$0	–	-104,078	–	-2.49%	–
OXFD	Exit	Oxford Immunotec Global PLC	$0	–	-1,032,370	–	-3.02%	–
BCRX	Exit	BioCryst Pharmaceuticals	$0	–	-3,324,705	–	-3.03%	–
CORI	Exit	Corium Intl Inc	$0	–	-1,675,479	–	-3.23%	–
AGEN	Exit	Agenus Inc	$0	–	-4,218,520	–	-3.24%	–
ABUS	Exit	Arbutus Biopharma Corp	$0	–	-5,266,280	–	-5.69%	–
ACHN	Exit	Achillion Pharmaceuticals In	$0	–	-7,839,766	–	-6.13%	–
LJPC	Exit	La Jolla Pharmaceutical Co	$0	–	-1,044,307	–	-6.33%	–
AVXS	Exit	Avexis Inc	$0	–	-467,667	–	-7.88%	–
RGNX	Exit	Regenxbio Inc	$0	–	-1,539,005	–	-8.83%	–
BMY	Exit	Bristol Myers Squibb Co	$0	–	-827,512	–	-9.19%	–
PTCT	Exit	PTC Therapeutics Inc	$0	–	-3,495,143	–	-12.18%	–
ALNY	Exit	Alnylam Pharmaceuticals Inc	$0	–	-623,338	–	-12.76%	–

Q3 2017

			Value		Shares		↓ Weighting
ALNY	Sell	Alnylam Pharmaceuticals Inc	$73,236,000	-11.8%	623,338	-40.1%	12.76%	-27.1%
PTCT	Buy	PTC Therapeutics Inc	$69,938,000	+15.5%	3,495,143	+5.8%	12.18%	-4.6%
BMY	Buy	Bristol Myers Squibb Co	$52,746,000	+22.2%	827,512	+6.8%	9.19%	+1.0%
RGNX	Buy	Regenxbio Inc	$50,710,000	+101.7%	1,539,005	+20.9%	8.83%	+66.7%
AVXS	Sell	Avexis Inc	$45,237,000	-6.2%	467,667	-20.3%	7.88%	-22.5%
LJPC	Sell	La Jolla Pharmaceutical Co	$36,321,000	+10.2%	1,044,307	-5.7%	6.33%	-9.0%
ACHN	Buy	Achillion Pharmaceuticals In	$35,201,000	+382.2%	7,839,766	+392.9%	6.13%	+298.3%
ABUS	Buy	Arbutus Biopharma Corp	$32,651,000	+74.1%	5,266,280	+1.1%	5.69%	+43.8%
AGEN	Sell	Agenus Inc	$18,604,000	+11.2%	4,218,520	-1.4%	3.24%	-8.1%
CORI	Buy	Corium Intl Inc	$18,564,000	+52.5%	1,675,479	+2.7%	3.23%	+25.9%
BCRX	Sell	BioCryst Pharmaceuticals	$17,421,000	-6.0%	3,324,705	-0.3%	3.03%	-22.4%
OXFD	Buy	Oxford Immunotec Global PLC	$17,344,000	+21.8%	1,032,370	+21.9%	3.02%	+0.6%
BLUE	Sell	bluebird bio Inc	$14,295,000	+30.4%	104,078	-0.3%	2.49%	+7.7%
OSUR	Sell	OraSure Technologies Inc	$12,053,000	+18.7%	535,707	-8.9%	2.10%	-1.9%
TCMD	Sell	Tactile Sys Technology Inc	$10,932,000	+2.7%	353,216	-5.1%	1.90%	-15.1%
MYOK	New	Myokardia Inc	$10,882,000	–	253,962	–	1.90%	–
ATRA	Sell	Atara Biotherapeutics Inc	$10,857,000	-33.9%	656,018	-44.1%	1.89%	-45.4%
MASI	Buy	Masimo Corp	$10,465,000	+13.8%	120,900	+19.8%	1.82%	-6.0%
VIVE	Buy	Viveve Med Inc	$7,719,000	-13.3%	1,473,028	+18.8%	1.34%	-28.4%
VRAY	Buy	Viewray Inc	$5,878,000	+18.9%	1,020,462	+33.5%	1.02%	-1.7%
SBPH	Sell	Spring Bk Pharmaceuticals In	$4,195,000	+23.9%	249,095	-0.4%	0.73%	+2.4%
BVX	New	Bovie Medical Corp	$3,852,000	–	1,139,600	–	0.67%	–
ZYNE	New	Zynerba Pharmaceuticals Inc	$1,672,000	–	200,000	–	0.29%	–
GBT	Sell	Global Blood Therapeutics In	$817,000	+13.3%	26,310	-0.3%	0.14%	-6.6%
ARGX	Sell	argenx SEsponsored adr	$563,000	+6.2%	24,906	-0.3%	0.10%	-12.5%
IVTY	Exit	Invuity Inc	$0	–	-23,830	–	-0.04%	–
PODD	Exit	Insulet Corp	$0	–	-58,000	–	-0.63%	–
UHS	Exit	Universal Health Services Inccl b	$0	–	-25,800	–	-0.66%	–
OMER	Exit	Omeros Corp	$0	–	-237,453	–	-1.00%	–

Q2 2017

			Value		Shares		↓ Weighting
ALNY	New	Alnylam Pharmaceuticals Inc	$82,999,000	–	1,040,607	–	17.50%	–
PTCT	New	PTC Therapeutics Inc	$60,566,000	–	3,304,214	–	12.77%	–
AVXS	New	Avexis Inc	$48,238,000	–	587,117	–	10.17%	–
BMY	New	Bristol-Myers Squibb Co	$43,165,000	–	774,675	–	9.10%	–
LJPC	New	La Jolla Pharmaceutical Co	$32,967,000	–	1,107,379	–	6.95%	–
RGNX	New	Regenxbio Inc	$25,137,000	–	1,272,770	–	5.30%	–
ABUS	New	Arbutus Biopharma Corp	$18,755,000	–	5,209,823	–	3.95%	–
BCRX	New	BioCryst Pharmaceuticals Inc	$18,537,000	–	3,333,958	–	3.91%	–
AGEN	New	Agenus Inc	$16,725,000	–	4,277,456	–	3.53%	–
ATRA	New	Atara Biotherapeutics Inc	$16,418,000	–	1,172,744	–	3.46%	–
OXFD	New	Oxford Immunotec Global PLC	$14,245,000	–	846,917	–	3.00%	–
CORI	New	Corium International Inc	$12,175,000	–	1,632,001	–	2.57%	–
BLUE	New	bluebird bio Inc	$10,965,000	–	104,383	–	2.31%	–
TCMD	New	Tactile Systems Technology Inc	$10,640,000	–	372,302	–	2.24%	–
OSUR	New	OraSure Technologies Inc	$10,153,000	–	588,256	–	2.14%	–
MASI	New	Masimo Corp	$9,200,000	–	100,900	–	1.94%	–
VIVE	New	Viveve Medical Inc	$8,899,000	–	1,239,443	–	1.88%	–
ACHN	New	Achillion Pharmaceuticals Inc	$7,300,000	–	1,590,454	–	1.54%	–
DRNA	New	Dicerna Pharmaceuticals Inc	$6,590,000	–	2,078,991	–	1.39%	–
VRAY	New	Viewray Inc	$4,945,000	–	764,335	–	1.04%	–
OMER	New	Omeros Corp	$4,727,000	–	237,453	–	1.00%	–
SBPH	New	Spring Bank Pharmaceuticals Inc	$3,385,000	–	250,000	–	0.71%	–
UHS	New	Universal Health Services Inccl b	$3,150,000	–	25,800	–	0.66%	–
PODD	New	Insulet Corp	$2,976,000	–	58,000	–	0.63%	–
GBT	New	Global Blood Therapeutics Inc	$721,000	–	26,377	–	0.15%	–
ARGX	New	Argenx Nvsponsored adr	$530,000	–	24,970	–	0.11%	–
IVTY	New	Invuity Inc	$173,000	–	23,830	–	0.04%	–
SRTSW	New	Sensus Heatlhcare Inc*w exp 06/08/201	$93,000	–	155,000	–	0.02%	–

Q4 2016

			Value		Shares		↓ Weighting
ABEO	Exit	Abeona Therapeutics Inc	$0	–	-19,391	–	-0.04%	–
NVLS	Exit	Nivalis Therapeutics Inc	$0	–	-30,000	–	-0.07%	–
MNKD	Exit	MANNKIND CORPput	$0	–	-4,385	–	-0.08%	–
NTRA	Exit	Natera Inc	$0	–	-31,693	–	-0.11%	–
BOLD	Exit	Audentes Therapeutics Inc	$0	–	-20,000	–	-0.11%	–
BPMX	Exit	Biopharmx Corp	$0	–	-700,636	–	-0.12%	–
SRTS	Exit	Sensus Healthcare Inc Cmn	$0	–	-125,700	–	-0.23%	–
MRTX	Exit	Mirati Therapeutics Inc	$0	–	-129,129	–	-0.26%	–
NVAX	Exit	NOVAVAX INCcall	$0	–	-4,787	–	-0.30%	–
MASI	Exit	Masimo Corp	$0	–	-25,900	–	-0.47%	–
GBT	Exit	Global Blood Therapeutics Inc	$0	–	-95,714	–	-0.67%	–
FPRX	Exit	Five Prime Therapeutics Inc	$0	–	-44,044	–	-0.70%	–
OXFD	Exit	Oxford Immunotec Global PLC	$0	–	-235,900	–	-0.90%	–
RGNX	Exit	Regenxbio Inc	$0	–	-238,740	–	-1.01%	–
JJOFF	Exit	Barclays Bank Plcetn djubscoffe38	$0	–	-180,500	–	-1.21%	–
TCMD	Exit	Tactile Systems Technology Inc Cmn	$0	–	-227,599	–	-1.29%	–
OMER	Exit	Omeros Corp	$0	–	-383,012	–	-1.29%	–
MDCO	Exit	Medicines Co	$0	–	-123,000	–	-1.40%	–
CLDX	Exit	Celldex Therapeutics Inc	$0	–	-1,243,164	–	-1.52%	–
IVTY	Exit	Invuity Inc	$0	–	-392,838	–	-1.63%	–
CORI	Exit	Corium International Inc	$0	–	-1,045,747	–	-1.78%	–
BLUE	Exit	bluebird bio Inc	$0	–	-87,734	–	-1.80%	–
VIVE	Exit	Viveve Medical Inc	$0	–	-839,274	–	-1.83%	–
HRTX	Exit	Heron Therapeutics Inc	$0	–	-386,787	–	-2.01%	–
ARWR	Exit	Arrowhead Pharmaceuticals Inc	$0	–	-1,116,777	–	-2.48%	–
	Exit	Atara Biotherapeutics Inc.	$0	–	-458,113	–	-2.96%	–
GLD	Exit	SPDR Gold Trust	$0	–	-83,000	–	-3.15%	–
BMY	Exit	Bristol-Myers Squibb Co	$0	–	-209,701	–	-3.42%	–
DRNA	Exit	Dicerna Pharmaceuticals Inc	$0	–	-2,026,894	–	-3.60%	–
ACHN	Exit	Achillion Pharmaceuticals Inc	$0	–	-2,208,749	–	-5.41%	–
INCY	Exit	Incyte Corp	$0	–	-191,151	–	-5.45%	–
BCRX	Exit	BioCryst Pharmaceuticals Inc	$0	–	-4,204,579	–	-5.60%	–
LJPC	Exit	La Jolla Pharmaceutical Co	$0	–	-1,170,151	–	-8.41%	–
AGEN	Exit	Agenus Inc	$0	–	-4,141,644	–	-8.99%	–
AVXS	Exit	Avexis Inc	$0	–	-825,980	–	-10.29%	–
ALNY	Exit	Alnylam Pharmaceuticals Inc	$0	–	-948,286	–	-19.42%	–

Q3 2016

			Value		Shares		↓ Weighting
ALNY	Buy	Alnylam Pharmaceuticals Inc	$64,275,000	+39.1%	948,286	+13.9%	19.42%	+23.1%
AVXS	Buy	Avexis Inc	$34,039,000	+87.9%	825,980	+73.4%	10.29%	+66.2%
AGEN	Buy	Agenus Inc	$29,737,000	+202.3%	4,141,644	+70.5%	8.99%	+167.4%
LJPC	Sell	La Jolla Pharmaceutical Co	$27,838,000	+47.9%	1,170,151	-0.5%	8.41%	+30.9%
BCRX	Buy	BioCryst Pharmaceuticals Inc	$18,542,000	+191.9%	4,204,579	+88.0%	5.60%	+158.1%
INCY	Sell	Incyte Corp	$18,024,000	-42.5%	191,151	-51.3%	5.45%	-49.2%
ACHN	Sell	Achillion Pharmaceuticals Inc	$17,891,000	-5.4%	2,208,749	-8.9%	5.41%	-16.3%
	New	Atara Biotherapeutics Inc.	$9,799,000	–	458,113	–	2.96%	–
ARWR	New	Arrowhead Pharmaceuticals Inc	$8,208,000	–	1,116,777	–	2.48%	–
HRTX	New	Heron Therapeutics Inc	$6,664,000	–	386,787	–	2.01%	–
VIVE	Buy	Viveve Medical Inc	$6,060,000	+81.4%	839,274	+3.0%	1.83%	+60.5%
BLUE	Sell	bluebird bio Inc	$5,947,000	-77.6%	87,734	-85.7%	1.80%	-80.1%
CORI	Buy	Corium International Inc	$5,888,000	+98.9%	1,045,747	+22.6%	1.78%	+76.0%
IVTY	Buy	Invuity Inc	$5,390,000	+150.2%	392,838	+73.8%	1.63%	+121.3%
CLDX	Sell	Celldex Therapeutics Inc	$5,022,000	-9.5%	1,243,164	-1.7%	1.52%	-19.9%
MDCO	New	Medicines Co	$4,642,000	–	123,000	–	1.40%	–
OMER	Sell	Omeros Corp	$4,274,000	-22.9%	383,012	-27.3%	1.29%	-31.7%
TCMD	New	Tactile Systems Technology Inc Cmn	$4,256,000	–	227,599	–	1.29%	–
JJOFF	Buy	Barclays Bank Plcetn djubscoffe38	$4,018,000	+25.8%	180,500	+25.2%	1.21%	+11.3%
RGNX	Sell	Regenxbio Inc	$3,345,000	+72.2%	238,740	-1.7%	1.01%	+52.5%
OXFD	New	Oxford Immunotec Global PLC	$2,963,000	–	235,900	–	0.90%	–
FPRX	Sell	Five Prime Therapeutics Inc	$2,312,000	+25.1%	44,044	-1.5%	0.70%	+10.8%
GBT	Sell	Global Blood Therapeutics Inc	$2,206,000	+36.8%	95,714	-1.5%	0.67%	+21.1%
NVAX	New	NOVAVAX INCcall	$996,000	–	4,787	–	0.30%	–
MRTX	Sell	Mirati Therapeutics Inc	$854,000	+19.3%	129,129	-1.5%	0.26%	+5.3%
SRTS	New	Sensus Healthcare Inc Cmn	$773,000	–	125,700	–	0.23%	–
BOLD	New	Audentes Therapeutics Inc	$356,000	–	20,000	–	0.11%	–
ABEO	New	Abeona Therapeutics Inc	$116,000	–	19,391	–	0.04%	–
MDRX	Exit	Allscripts Healthcare Solutions Inc	$0	–	-48,000	–	-0.21%	–
SRTSU	Exit	Sensus Healthcare Incunit 99/99/9999	$0	–	-155,000	–	-0.34%	–
CYTR	Exit	CytRx Corp	$0	–	-466,200	–	-0.36%	–
AXDX	Exit	Accelerate Diagnostics Inc	$0	–	-74,843	–	-0.37%	–
ICPT	Exit	Intercept Pharmaceuticals Inc	$0	–	-39,500	–	-1.93%	–
TLT	Exit	iShares 20+ Year Treasury Bond ETF20 yr tr bd etf	$0	–	-45,000	–	-2.14%	–
ATRA	Exit	Atara Biotherapeutics Inc.	$0	–	-465,874	–	-3.58%	–
SSRG	Exit	Symmetry Surgical Inc	$0	–	-922,215	–	-4.14%	–
KITE	Exit	Kite Pharma Inc	$0	–	-285,518	–	-4.88%	–

Q2 2016

			Value		Shares		↓ Weighting
ALNY	New	Alnylam Pharmaceuticals Inc	$46,198,000	–	832,549	–	15.78%	–
INCY	New	Incyte Corp	$31,371,000	–	392,236	–	10.72%	–
BLUE	New	bluebird bio Inc	$26,495,000	–	612,025	–	9.05%	–
ACHN	New	Achillion Pharmaceuticals Inc	$18,908,000	–	2,424,136	–	6.46%	–
LJPC	New	La Jolla Pharmaceutical Co	$18,818,000	–	1,176,146	–	6.43%	–
AVXS	New	Avexis Inc	$18,111,000	–	476,367	–	6.19%	–
BMY	New	Bristol-Myers Squibb Co	$15,424,000	–	209,701	–	5.27%	–
KITE	New	Kite Pharma Inc	$14,276,000	–	285,518	–	4.88%	–
SSRG	New	Symmetry Surgical Inc	$12,109,000	–	922,215	–	4.14%	–
GLD	New	SPDR Gold Shares ETF	$10,497,000	–	83,000	–	3.59%	–
ATRA	New	Atara Biotherapeutics Inc.	$10,487,000	–	465,874	–	3.58%	–
AGEN	New	Agenus Inc	$9,838,000	–	2,429,149	–	3.36%	–
BCRX	New	BioCryst Pharmaceuticals Inc	$6,353,000	–	2,237,066	–	2.17%	–
TLT	New	iShares 20+ Year Treasury Bond ETF20 yr tr bd etf	$6,251,000	–	45,000	–	2.14%	–
DRNA	New	Dicerna Pharmaceuticals Inc	$6,081,000	–	2,026,894	–	2.08%	–
ICPT	New	Intercept Pharmaceuticals Inc	$5,636,000	–	39,500	–	1.93%	–
CLDX	New	Celldex Therapeutics Inc	$5,550,000	–	1,264,227	–	1.90%	–
OMER	New	Omeros Corp	$5,542,000	–	526,788	–	1.89%	–
VIVE	New	Viveve Medical Inc	$3,341,000	–	814,946	–	1.14%	–
JJOFF	New	Barclays Bank iPath Dow Jones-UBS Coffee Subindex TR ETNetn djubscoffe38	$3,194,000	–	144,200	–	1.09%	–
CORI	New	Corium International Inc	$2,960,000	–	852,961	–	1.01%	–
IVTY	New	Invuity Inc	$2,154,000	–	226,042	–	0.74%	–
RGNX	New	Regenxbio Inc	$1,942,000	–	242,784	–	0.66%	–
FPRX	New	Five Prime Therapeutics Inc	$1,848,000	–	44,701	–	0.63%	–
GBT	New	Global Blood Therapeutics Inc	$1,612,000	–	97,138	–	0.55%	–
MASI	New	Masimo Corp	$1,360,000	–	25,900	–	0.46%	–
AXDX	New	Accelerate Diagnostics Inc	$1,077,000	–	74,843	–	0.37%	–
CYTR	New	CytRx Corp	$1,040,000	–	466,200	–	0.36%	–
SRTSU	New	Sensus Healthcare Incunit 99/99/9999	$1,006,000	–	155,000	–	0.34%	–
MNKD	New	MNKD 01/20/2017 PUT 3put	$912,000	–	4,385	–	0.31%	–
MRTX	New	Mirati Therapeutics Inc	$716,000	–	131,052	–	0.24%	–
MDRX	New	Allscripts Healthcare Solutions Inc	$610,000	–	48,000	–	0.21%	–
BPMX	New	Biopharmx Corp	$455,000	–	700,636	–	0.16%	–
NTRA	New	Natera Inc	$382,000	–	31,693	–	0.13%	–
NVLS	New	Nivalis Therapeutics Inc	$138,000	–	30,000	–	0.05%	–

Q4 2015

			Value		Shares		↓ Weighting
	Exit	Berkshire Hathaway Inccl b new	$0	–	-50	–	-0.00%	–
USO	Exit	USO 01/15/2016 CALL 25call	$0	–	-13,850	–	-0.01%	–
VIVO	Exit	VIVO 01/15/2016 CALL 20call	$0	–	-1,252	–	-0.02%	–
ADAP	Exit	Adaptimmune Therapeutics-adrsponds adr	$0	–	-7,028	–	-0.03%	–
VCYT	Exit	Veracyte Inc	$0	–	-25,000	–	-0.04%	–
ELGX	Exit	Endologix Inc	$0	–	-15,000	–	-0.06%	–
GHDX	Exit	Genomic Health Inc	$0	–	-15,000	–	-0.10%	–
NTRA	Exit	Natera Inc	$0	–	-31,693	–	-0.11%	–
BPMX	Exit	Biopharmx Corp	$0	–	-370,636	–	-0.12%	–
NVLS	Exit	Nivalis Therapeutics Inc	$0	–	-30,000	–	-0.12%	–
BCRX	Exit	BCRX 12/18/2015 CALL 12call	$0	–	-2,000	–	-0.13%	–
MDRX	Exit	Allscripts Healthcare Solutions Inc	$0	–	-48,000	–	-0.18%	–
MASI	Exit	Masimo Corp	$0	–	-25,900	–	-0.31%	–
NLNK	Exit	NewLink Genetics Corp	$0	–	-28,291	–	-0.32%	–
CYTR	Exit	CytRx Corp	$0	–	-453,465	–	-0.33%	–
OSUR	Exit	OraSure Technologies Inc	$0	–	-322,996	–	-0.45%	–
VBIV	Exit	Vbi Vaccines Inc	$0	–	-650,000	–	-0.53%	–
RPRX	Exit	Repros Therapeutics Inc	$0	–	-232,830	–	-0.54%	–
CBIO	Exit	Catalyst Biosciences Inc	$0	–	-380,806	–	-0.55%	–
LENS	Exit	Presbia Plc	$0	–	-350,000	–	-0.60%	–
DYAX	Exit	Dyax Corp	$0	–	-115,358	–	-0.68%	–
IVTY	Exit	Invuity Inc	$0	–	-175,000	–	-0.76%	–
LPCN	Exit	Lipocine Inc	$0	–	-212,497	–	-0.78%	–
BMY	Exit	BMY 01/15/2016 CALL 60call	$0	–	-7,500	–	-0.80%	–
GBT	Exit	Global Blood Therapeutics Inc	$0	–	-92,399	–	-1.21%	–
RGNX	Exit	Regenxbio Inc	$0	–	-204,494	–	-1.40%	–
OMER	Exit	Omeros Corp	$0	–	-490,000	–	-1.67%	–
CORI	Exit	Corium International Inc	$0	–	-575,212	–	-1.67%	–
BMY	Exit	Bristol-Myers Squibb Co	$0	–	-102,425	–	-1.88%	–
SSRG	Exit	Symmetry Surgical Inc	$0	–	-807,442	–	-2.23%	–
CLDX	Exit	Celldex Therapeutics Inc	$0	–	-718,729	–	-2.35%	–
	Exit	Atara Biotherapeutics Inc.	$0	–	-262,995	–	-2.57%	–
AGEN	Exit	Agenus Inc	$0	–	-2,084,142	–	-2.98%	–
FPRX	Exit	Five Prime Therapeutics Inc	$0	–	-713,954	–	-3.41%	–
	Exit	Arrowhead Research Corp	$0	–	-2,097,185	–	-3.75%	–
BLUE	Exit	bluebird bio Inc	$0	–	-151,594	–	-4.03%	–
DRNA	Exit	Dicerna Pharmaceuticals Inc	$0	–	-2,005,238	–	-5.12%	–
MRTX	Exit	Mirati Therapeutics Inc	$0	–	-482,069	–	-5.16%	–
ACHN	Exit	Achillion Pharmaceuticals Inc	$0	–	-2,589,818	–	-5.56%	–
KITE	Exit	Kite Pharma Inc	$0	–	-375,476	–	-6.50%	–
BCRX	Exit	BioCryst Pharmaceuticals Inc	$0	–	-2,228,206	–	-7.89%	–
LJPC	Exit	La Jolla Pharmaceutical Co	$0	–	-1,080,331	–	-9.33%	–
INCY	Exit	Incyte Corp	$0	–	-303,212	–	-10.39%	–
ALNY	Exit	Alnylam Pharmaceuticals Inc	$0	–	-533,660	–	-13.32%	–

Q3 2015

			Value		Shares		↓ Weighting
ALNY	Buy	Alnylam Pharmaceuticals Inc	$42,885,000	-13.0%	533,660	+29.8%	13.32%	-7.1%
INCY	Buy	Incyte Corp	$33,453,000	+64.6%	303,212	+55.5%	10.39%	+75.7%
LJPC	Buy	La Jolla Pharmaceutical Co	$30,022,000	+331.8%	1,080,331	+280.8%	9.33%	+360.9%
BCRX	Sell	BioCryst Pharmaceuticals Inc	$25,402,000	-24.8%	2,228,206	-1.5%	7.89%	-19.7%
KITE	Sell	Kite Pharma Inc	$20,907,000	-14.3%	375,476	-6.1%	6.50%	-8.5%
ACHN	Buy	Achillion Pharmaceuticals Inc	$17,896,000	-19.7%	2,589,818	+3.0%	5.56%	-14.3%
MRTX	New	Mirati Therapeutics Inc	$16,593,000	–	482,069	–	5.16%	–
DRNA	Buy	Dicerna Pharmaceuticals Inc	$16,463,000	-7.8%	2,005,238	+56.7%	5.12%	-1.6%
BLUE	Buy	bluebird bio Inc	$12,969,000	-26.6%	151,594	+44.4%	4.03%	-21.7%
	New	Arrowhead Research Corp	$12,080,000	–	2,097,185	–	3.75%	–
FPRX	Buy	Five Prime Therapeutics Inc	$10,988,000	-21.1%	713,954	+27.4%	3.41%	-15.7%
AGEN	Buy	Agenus Inc	$9,587,000	-45.9%	2,084,142	+1.5%	2.98%	-42.2%
	New	Atara Biotherapeutics Inc.	$8,269,000	–	262,995	–	2.57%	–
CLDX	Buy	Celldex Therapeutics Inc	$7,575,000	-36.3%	718,729	+52.4%	2.35%	-32.0%
SSRG	Buy	Symmetry Surgical Inc	$7,186,000	+17.6%	807,442	+15.2%	2.23%	+25.5%
BMY	Buy	Bristol-Myers Squibb Co	$6,064,000	-6.5%	102,425	+5.1%	1.88%	-0.2%
CORI	Buy	Corium International Inc	$5,378,000	+10.7%	575,212	+62.0%	1.67%	+18.1%
OMER	New	Omeros Corp	$5,370,000	–	490,000	–	1.67%	–
RGNX	New	Regenxbio Inc	$4,505,000	–	204,494	–	1.40%	–
GBT	New	Global Blood Therapeutics Inc	$3,896,000	–	92,399	–	1.21%	–
BMY	New	BMY 01/15/2016 CALL 60call	$2,588,000	–	7,500	–	0.80%	–
LPCN	Buy	Lipocine Inc	$2,514,000	+40.0%	212,497	+1.5%	0.78%	+49.3%
IVTY	Buy	Invuity Inc	$2,454,000	+5.3%	175,000	+6.1%	0.76%	+12.4%
DYAX	Sell	Dyax Corp	$2,202,000	-85.1%	115,358	-79.4%	0.68%	-84.1%
CBIO	New	Catalyst Biosciences Inc	$1,775,000	–	380,806	–	0.55%	–
RPRX	Buy	Repros Therapeutics Inc	$1,730,000	+5.5%	232,830	+1.5%	0.54%	+12.8%
VBIV	New	Vbi Vaccines Inc	$1,716,000	–	650,000	–	0.53%	–
OSUR	New	OraSure Technologies Inc	$1,434,000	–	322,996	–	0.45%	–
CYTR	Buy	CytRx Corp	$1,075,000	-35.3%	453,465	+1.5%	0.33%	-31.0%
NLNK	Sell	NewLink Genetics Corp	$1,014,000	-77.1%	28,291	-71.7%	0.32%	-75.6%
MASI	New	Masimo Corp	$999,000	–	25,900	–	0.31%	–
MDRX	New	Allscripts Healthcare Solutions Inc	$595,000	–	48,000	–	0.18%	–
BCRX	New	BCRX 12/18/2015 CALL 12call	$431,000	–	2,000	–	0.13%	–
NTRA	New	Natera Inc	$344,000	–	31,693	–	0.11%	–
GHDX	New	Genomic Health Inc	$317,000	–	15,000	–	0.10%	–
ELGX	New	Endologix Inc	$184,000	–	15,000	–	0.06%	–
VCYT	New	Veracyte Inc	$117,000	–	25,000	–	0.04%	–
ADAP	Sell	Adaptimmune Therapeutics-adrsponds adr	$84,000	-77.1%	7,028	-64.9%	0.03%	-75.7%
VIVO	New	VIVO 01/15/2016 CALL 20call	$50,000	–	1,252	–	0.02%	–
USO	New	USO 01/15/2016 CALL 25call	$42,000	–	13,850	–	0.01%	–
	New	Berkshire Hathaway Inccl b new	$7,000	–	50	–	0.00%	–
BRKB	Exit	Berkshire Hathaway Inc	$0	–	-50	–	-0.00%	–
FBIO	Exit	Fortress Biotech Inc	$0	–	-11,917	–	-0.01%	–
	Exit	Valeant Pharmaceuticals Intl VRX 10/16/2015 CALL 260call	$0	–	-150	–	-0.02%	–
ZGNX	Exit	Zogenix Inc	$0	–	-114,128	–	-0.06%	–
	Exit	Meridian Bioscience Inc. VIVO 10/16/2015 CALL 20call	$0	–	-3,756	–	-0.08%	–
USO	Exit	United States Oil ETF	$0	–	-165,000	–	-0.96%	–
TLT	Exit	iShares 20+ Year Treasury Bond ETF	$0	–	-33,000	–	-1.13%	–
	Exit	Bristol Myers Squibb Co 01/15/2016 CALL 60call	$0	–	-7,500	–	-1.78%	–
TRGT	Exit	Targacept Inc	$0	–	-2,665,643	–	-2.16%	–
ARWR	Exit	Arrowhead Research Corp	$0	–	-2,560,000	–	-5.33%	–
	Exit	La Jolla Pharmaceutical Company Cmn Di	$0	–	-780,547	–	-5.57%	–

Q2 2015

			Value		Shares		↓ Weighting
ALNY	New	Alnylam Pharmaceuticals Inc	$49,268,000	–	411,016	–	14.34%	–
BCRX	New	BioCryst Pharmaceuticals Inc	$33,762,000	–	2,261,361	–	9.83%	–
KITE	New	Kite Pharma Inc	$24,388,000	–	400,000	–	7.10%	–
ACHN	New	Achillion Pharmaceuticals Inc	$22,287,000	–	2,515,433	–	6.49%	–
INCY	New	Incyte Corp	$20,321,000	–	195,000	–	5.92%	–
	New	La Jolla Pharmaceutical Company Cmn Di	$19,131,000	–	780,547	–	5.57%	–
ARWR	New	Arrowhead Research Corp	$18,304,000	–	2,560,000	–	5.33%	–
DRNA	New	Dicerna Pharmaceuticals Inc	$17,854,000	–	1,279,886	–	5.20%	–
AGEN	New	Agenus Inc	$17,717,000	–	2,052,915	–	5.16%	–
BLUE	New	bluebird bio Inc	$17,679,000	–	105,000	–	5.15%	–
DYAX	New	Dyax Corp	$14,817,000	–	559,141	–	4.31%	–
FPRX	New	Five Prime Therapeutics Inc	$13,921,000	–	560,437	–	4.05%	–
CLDX	New	Celldex Therapeutics Inc	$11,893,000	–	471,554	–	3.46%	–
TRGT	New	Targacept Inc	$7,437,000	–	2,665,643	–	2.16%	–
LJPC	New	La Jolla Pharmaceutical Co	$6,953,000	–	283,700	–	2.02%	–
BMY	New	Bristol-Myers Squibb Co	$6,485,000	–	97,454	–	1.89%	–
	New	Bristol Myers Squibb Co 01/15/2016 CALL 60call	$6,113,000	–	7,500	–	1.78%	–
SSRG	New	Symmetry Surgical Inc	$6,111,000	–	700,851	–	1.78%	–
CORI	New	Corium International Inc	$4,860,000	–	355,007	–	1.42%	–
NLNK	New	NewLink Genetics Corp	$4,427,000	–	100,000	–	1.29%	–
TLT	New	iShares 20+ Year Treasury Bond ETF	$3,876,000	–	33,000	–	1.13%	–
USO	New	United States Oil ETF	$3,280,000	–	165,000	–	0.96%	–
LENS	New	Presbia Plc	$2,877,000	–	350,000	–	0.84%	–
IVTY	New	Invuity Inc	$2,330,000	–	165,000	–	0.68%	–
LPCN	New	Lipocine Inc	$1,796,000	–	209,333	–	0.52%	–
CYTR	New	CytRx Corp	$1,662,000	–	446,714	–	0.48%	–
RPRX	New	Repros Therapeutics Inc	$1,640,000	–	229,364	–	0.48%	–
BPMX	New	Biopharmx Corp	$949,000	–	370,636	–	0.28%	–
NVLS	New	Nivalis Therapeutics Inc	$455,000	–	30,000	–	0.13%	–
ADAP	New	Adaptimmune Therapeutics-adr	$367,000	–	20,000	–	0.11%	–
	New	Meridian Bioscience Inc. VIVO 10/16/2015 CALL 20call	$260,000	–	3,756	–	0.08%	–
ZGNX	New	Zogenix Inc	$192,000	–	114,128	–	0.06%	–
	New	Valeant Pharmaceuticals Intl VRX 10/16/2015 CALL 260call	$78,000	–	150	–	0.02%	–
FBIO	New	Fortress Biotech Inc	$40,000	–	11,917	–	0.01%	–
BRKB	New	Berkshire Hathaway Inc	$7,000	–	50	–	0.00%	–

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