$6.63 Billion is the total value of RA Capital Management's 82 reported holdings in Q1 2021. The portfolio turnover from Q4 2020 to Q1 2021 was 46.3% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| ASND | Buy | ASCENDIS PHARMA A/Ssponsored adr | $826,408,000 | -15.5% | 6,412,228 | +9.3% | 12.46% | -8.9% |
| NVAX | Sell | NOVAVAX INC | $544,308,000 | +28.8% | 3,002,087 | -20.8% | 8.21% | +39.0% |
| VOR | New | VOR BIOPHARMA INC | $479,314,000 | – | 11,120,973 | +100.0% | 7.23% | – |
| AVIR | ATEA PHARMACEUTICALS INC | $331,502,000 | +47.8% | 5,368,451 | 0.0% | 5.00% | +59.5% | |
| FMTX | FORMA THERAPEUTICS HLDGS INC | $252,506,000 | -19.7% | 9,011,651 | 0.0% | 3.81% | -13.4% | |
| TGTX | Sell | TG THERAPEUTICS INC | $223,462,000 | -50.5% | 4,636,146 | -46.6% | 3.37% | -46.6% |
| NKTX | NKARTA INC | $184,409,000 | -46.5% | 5,605,129 | 0.0% | 2.78% | -42.3% | |
| CCXI | Sell | CHEMOCENTRYX INC | $182,251,000 | -38.4% | 3,556,810 | -25.5% | 2.75% | -33.5% |
| MGNX | Buy | MACROGENICS INC | $157,135,000 | +57.1% | 4,933,594 | +12.8% | 2.37% | +69.5% |
| ITOS | ITEOS THERAPEUTICS INC | $150,982,000 | +1.1% | 4,417,258 | 0.0% | 2.28% | +9.1% | |
| IMGN | IMMUNOGEN INC | $149,181,000 | +25.6% | 18,417,458 | 0.0% | 2.25% | +35.4% | |
| TVTX | Buy | TRAVERE THERAPEUTICS INC | $140,192,000 | +12.9% | 5,614,428 | +23.2% | 2.11% | +21.7% |
| TIL | New | INSTIL BIO INC | $122,159,000 | – | 4,870,793 | +100.0% | 1.84% | – |
| PHAT | Sell | PHATHOM PHARMACEUTICALS INC | $117,000,000 | -7.9% | 3,115,008 | -18.6% | 1.76% | -0.7% |
| ETNB | 89BIO INC | $112,154,000 | -2.8% | 4,736,214 | 0.0% | 1.69% | +4.8% | |
| KNTE | KINNATE BIOPHARMA INC | $111,960,000 | -21.7% | 3,593,052 | 0.0% | 1.69% | -15.5% | |
| RYTM | Buy | RHYTHM PHARMACEUTICALS INC | $103,608,000 | -16.6% | 4,871,067 | +16.6% | 1.56% | -10.1% |
| ZGNX | Sell | ZOGENIX INC | $103,143,000 | -3.5% | 5,283,976 | -1.2% | 1.56% | +4.1% |
| AXSM | AXSOME THERAPEUTICS INC | $93,731,000 | -30.5% | 1,655,447 | 0.0% | 1.41% | -25.0% | |
| RCKT | Sell | ROCKET PHARMACEUTICALS INC COM | $93,494,000 | -20.2% | 2,107,149 | -1.4% | 1.41% | -13.9% |
| ADVM | Sell | ADVERUM BIOTECHNOLOGIES INC | $92,347,000 | -10.3% | 9,365,833 | -1.4% | 1.39% | -3.3% |
| EWTX | New | EDGEWISE THERAPEUTICS INC | $84,943,000 | – | 2,613,623 | +100.0% | 1.28% | – |
| CRIS | Sell | CURIS INC | $80,826,000 | +28.0% | 7,140,091 | -7.4% | 1.22% | +38.2% |
| BOLT | New | BOLT BIOTHERAPEUTICS INC | $78,271,000 | – | 2,378,325 | +100.0% | 1.18% | – |
| PCVX | Buy | VAXCYTE INC | $76,350,000 | -22.6% | 3,865,808 | +4.2% | 1.15% | -16.5% |
| MCRB | New | SERES THERAPEUTICS INC | $76,063,000 | – | 3,694,193 | +100.0% | 1.15% | – |
| SBTX | SILVERBACK THERAPEUTICS INC | $76,012,000 | -5.8% | 1,742,186 | 0.0% | 1.15% | +1.5% | |
| IGMS | IGM BIOSCIENCES INC | $75,365,000 | -13.1% | 982,723 | 0.0% | 1.14% | -6.3% | |
| KALA | KALA PHARMACEUTICALS INC | $73,295,000 | -0.6% | 10,874,613 | 0.0% | 1.10% | +7.2% | |
| OLMA | OLEMA PHARMACEUTICALS INC | $71,350,000 | -31.0% | 2,150,404 | 0.0% | 1.08% | -25.5% | |
| ORTX | ORCHARD THERAPEUTICS PLCads | $69,164,000 | +68.1% | 12,315,213 | 0.0% | 1.04% | +81.4% | |
| SLDB | Buy | SOLID BIOSCIENCES INC | $68,394,000 | -9.6% | 12,367,873 | +24.0% | 1.03% | -2.5% |
| DSGN | New | DESIGN THERAPEUTICS INC | $65,380,000 | – | 2,186,636 | +100.0% | 0.99% | – |
| BDTX | BLACK DIAMOND THERAPEUTICS INC | $62,831,000 | -24.3% | 2,589,904 | 0.0% | 0.95% | -18.4% | |
| TRILLIUM THERAPEUTICS INC | $56,820,000 | -27.0% | 5,290,481 | 0.0% | 0.86% | -21.2% | ||
| PMVP | PMV PHARMACEUTICALS INC | $56,251,000 | -46.5% | 1,710,265 | 0.0% | 0.85% | -42.4% | |
| CNTB | New | CONNECT BIOPHARMA HLDGS LTDads | $55,337,000 | – | 2,991,208 | +100.0% | 0.83% | – |
| CNST | Buy | CONSTELLATION PHARMCETICLS INC | $52,359,000 | -1.9% | 2,238,536 | +20.8% | 0.79% | +5.9% |
| CCCC | C4 THERAPEUTICS INC | $50,956,000 | +11.7% | 1,377,569 | 0.0% | 0.77% | +20.4% | |
| STRO | SUTRO BIOPHARMA INC | $48,211,000 | +4.8% | 2,118,212 | 0.0% | 0.73% | +13.1% | |
| GERN | GERON CORP | $47,600,000 | -0.6% | 30,126,299 | 0.0% | 0.72% | +7.2% | |
| WVE | WAVE LIFE SCIENCES LTD | $43,619,000 | -28.7% | 7,775,207 | 0.0% | 0.66% | -23.0% | |
| DYN | DYNE THERAPEUTICS INC | $43,562,000 | -26.0% | 2,805,045 | 0.0% | 0.66% | -20.2% | |
| VRNA | VERONA PHARMA PLCsponsored ads | $42,636,000 | +34.0% | 5,100,000 | 0.0% | 0.64% | +44.5% | |
| ARDX | Sell | ARDELYX INC | $40,232,000 | +0.9% | 6,077,294 | -1.4% | 0.61% | +9.0% |
| INZY | INOZYME PHARMA INC | $39,672,000 | -4.1% | 2,003,653 | 0.0% | 0.60% | +3.5% | |
| STSA | Buy | SATSUMA PHARMACEUTICALS INC | $34,953,000 | +61.9% | 5,914,252 | +26.3% | 0.53% | +74.5% |
| RLAY | RELAY THERAPEUTICS INC | $34,570,000 | -16.8% | 1,000,000 | 0.0% | 0.52% | -10.3% | |
| AKUS | AKOUOS INC | $31,641,000 | -30.1% | 2,281,249 | 0.0% | 0.48% | -24.5% | |
| CERE | CEREVEL THERAPEUTICS HLDNG INC | $30,206,000 | -17.2% | 2,200,000 | 0.0% | 0.46% | -10.8% | |
| CTMX | New | CYTOMX THERAPEUTICS INC | $27,055,000 | – | 3,500,000 | +100.0% | 0.41% | – |
| ACHL | New | ACHILLES THERAPEUTICS PLCsponsored ads | $22,986,000 | – | 1,388,888 | +100.0% | 0.35% | – |
| SNDX | SYNDAX PHARMACEUTICALS INC | $22,876,000 | +0.5% | 1,023,067 | 0.0% | 0.34% | +8.5% | |
| LRMR | LARIMAR THERAPEUTICS INC | $22,136,000 | -31.8% | 1,515,151 | 0.0% | 0.33% | -26.3% | |
| IKNA | New | IKENA ONCOLOGY INC | $21,188,000 | – | 750,000 | +100.0% | 0.32% | – |
| SCPH | Sell | SCPHARMACEUTICALS INC | $18,162,000 | -2.4% | 2,731,170 | -22.4% | 0.27% | +5.4% |
| CNCE | Buy | CONCERT PHARMACEUTICALS INC | $15,138,000 | -34.3% | 3,033,603 | +66.4% | 0.23% | -29.2% |
| CGEM | New | CULLINAN ONCOLOGY INC COM | $14,585,000 | – | 350,000 | +100.0% | 0.22% | – |
| ORIC | ORIC PHARMACEUTICALS INC | $14,308,000 | -27.6% | 584,000 | 0.0% | 0.22% | -21.7% | |
| PRQR | New | PROQR THERAPEUTICS N V | $13,998,000 | – | 2,117,669 | +100.0% | 0.21% | – |
| BCTG | BCTG ACQUISITION CORP | $13,900,000 | -2.8% | 1,250,000 | 0.0% | 0.21% | +5.0% | |
| ARYA | Sell | ARYA SCIENCES ACQUISITION CO | $13,386,000 | +23.4% | 971,430 | -2.9% | 0.20% | +32.9% |
| BLSA | BCLS ACQUISITION CORP | $13,213,000 | -5.1% | 1,250,000 | 0.0% | 0.20% | +2.1% | |
| MIST | Sell | MILESTONE PHARMACEUTICALS INC | $13,007,000 | -16.6% | 2,246,503 | -3.5% | 0.20% | -10.1% |
| EYPT | New | EYEPOINT PHARMACEUTICALS INC | $12,700,000 | – | 1,250,000 | +100.0% | 0.19% | – |
| RPTX | REPARE THERAPEUTICS INC | $12,552,000 | -10.5% | 409,000 | 0.0% | 0.19% | -3.6% | |
| OCUL | OCULAR THERAPEUTIX INC | $12,308,000 | -20.7% | 750,000 | 0.0% | 0.19% | -14.3% | |
| TXMD | THERAPEUTICSMD INC | $10,469,000 | +10.7% | 7,812,500 | 0.0% | 0.16% | +19.7% | |
| ARYD | New | ARYA SCIENCES ACQU CORP IVcl a | $10,473,000 | – | 1,000,000 | +100.0% | 0.16% | – |
| FLACU | FRAZIER LIFESCIENCES ACQUISITION COunit 12/09/2025 | $10,160,000 | -2.1% | 1,000,000 | 0.0% | 0.15% | +5.5% | |
| FSII | New | FS DEVELOPMENT CORP II | $9,960,000 | – | 1,000,000 | +100.0% | 0.15% | – |
| PHAS | New | PHASEBIO PHARMACEUTICALS INC | $9,861,000 | – | 2,850,000 | +100.0% | 0.15% | – |
| KALV | New | KALVISTA PHARMACEUTICALS INC | $8,992,000 | – | 350,000 | +100.0% | 0.14% | – |
| COGT | COGENT BIOSCIENCES INC | $9,005,000 | -21.8% | 1,025,641 | 0.0% | 0.14% | -15.5% | |
| FVAM | 5 01 ACQUISITION CORP | $7,463,000 | -2.2% | 750,000 | 0.0% | 0.11% | +5.6% | |
| HLXA | HELIX ACQUISITION CORP | $7,147,000 | -10.2% | 700,000 | 0.0% | 0.11% | -2.7% | |
| HSAQ | HEALTH SCIENCES ACQ CORP 2 | $6,994,000 | -12.6% | 625,000 | 0.0% | 0.10% | -6.2% | |
| SYRS | New | SYROS PHARMACEUTICALS INC | $6,732,000 | – | 900,000 | +100.0% | 0.10% | – |
| VRDN | New | VIRIDIAN THERAPEUTICS INC | $5,219,000 | – | 312,328 | +100.0% | 0.08% | – |
| XFOR | X4 PHARMACEUTICALS INC | $4,623,000 | +33.9% | 536,962 | 0.0% | 0.07% | +45.8% | |
| IMRA | IMARA INC | $2,100,000 | -61.7% | 248,804 | 0.0% | 0.03% | -58.4% | |
| CEREW | CEREVEL THERAPEUTICS HLDNG INC*w exp 06/09/2027 | $1,006,000 | -23.7% | 233,333 | 0.0% | 0.02% | -16.7% | |
| OVID | Exit | OVID THERAPEUTICS INC | $0 | – | -285,000 | -100.0% | -0.01% | – |
| PROF | Exit | PROFOUND MEDICAL CORP | $0 | – | -192,311 | -100.0% | -0.06% | – |
| MGEN | Exit | MIRAGEN THERAPEUTICS INC | $0 | – | -451,932 | -100.0% | -0.10% | – |
| CRNX | Exit | CRINETICS PHARMACEUTICALS INC | $0 | – | -564,102 | -100.0% | -0.11% | – |
| PASG | Exit | PASSAGE BIO INC | $0 | – | -322,630 | -100.0% | -0.12% | – |
| LYRA | Exit | LYRA THERAPEUTICS INC | $0 | – | -815,849 | -100.0% | -0.13% | – |
| ADAP | Exit | ADAPTIMMUNE THERAPEUTICS PLCsponds adr | $0 | – | -2,499,025 | -100.0% | -0.19% | – |
| VXRT | Exit | VAXART INC | $0 | – | -2,742,271 | -100.0% | -0.22% | – |
| Exit | MARINUS PHARMACEUTICALS INC | $0 | – | -1,300,000 | -100.0% | -0.22% | – | |
| ALEC | Exit | ALECTOR INC | $0 | – | -1,616,879 | -100.0% | -0.34% | – |
| PAND | Exit | PANDION THERAPEUTICS INC | $0 | – | -1,770,023 | -100.0% | -0.37% | – |
| ARQT | Exit | ARCUTIS BIOTHERAPEUTICS INC | $0 | – | -1,165,184 | -100.0% | -0.46% | – |
| PACB | Exit | PACIFIC BIOSCIENCES OF CALIFORNIA INC | $0 | – | -1,987,997 | -100.0% | -0.72% | – |
| CRDF | Exit | CARDIFF ONCOLOGY INC | $0 | – | -3,290,000 | -100.0% | -0.83% | – |
| LEGN | Exit | LEGEND BIOTECH CORPsponsored ads | $0 | – | -2,408,292 | -100.0% | -0.95% | – |
| INBX | Exit | INHIBRX INC | $0 | – | -2,129,003 | -100.0% | -0.98% | – |
| FPRX | Exit | FIVE PRIME THERAPEUTICS INC | $0 | – | -4,285,161 | -100.0% | -1.02% | – |
| KROS | Exit | KEROS THERAPEUTICS INC | $0 | – | -1,875,000 | -100.0% | -1.85% | – |
| ARVN | Exit | ARVINAS INC | $0 | – | -3,672,872 | -100.0% | -4.36% | – |
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2021-05-17
About RA Capital Management
RA Capital Management is a Boston-based investment management firm that specializes in the healthcare sector. The firm was founded in 2001 by Peter Kolchinsky, a former biotech analyst at Lehman Brothers. Since then, RA Capital has grown to become one of the most respected healthcare investment firms in the world, with over $5 billion in assets under management.
The firm's investment strategy is focused on identifying and investing in companies that are developing innovative therapies and technologies that have the potential to transform the healthcare industry. RA Capital's team of experienced analysts and portfolio managers conduct extensive research and due diligence to identify the most promising investment opportunities in the healthcare sector.
RA Capital's portfolio includes a diverse range of companies, from early-stage startups to established biotech and pharmaceutical companies. Some of the notable companies in RA Capital's portfolio include Moderna, a biotech company that is developing a COVID-19 vaccine, and Intellia Therapeutics, a gene editing company that is developing therapies for genetic diseases.
Peter Kolchinsky, the founder and CEO of RA Capital, is a well-respected figure in the healthcare investment community. He is a frequent speaker at industry conferences and has authored several books on biotech investing. Other key members of RA Capital's management team include Rajeev Shah, the firm's COO, and Derek DiRocco, the Chief Investment Officer.
Overall, RA Capital Management is a highly respected investment firm that has a proven track record of identifying and investing in innovative healthcare companies. Investors who are interested in the healthcare sector may want to consider RA Capital as a potential investment opportunity.
It's important to note that this information is for educational purposes only and has not been fact-checked. As with any investment, it's important to do your own research and consult with a financial advisor before making any investment decisions.
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| ASCENDIS PHARMA A/S - ADR | 35 | Q3 2023 | 25.5% |
| WAVE LIFE SCIENCES PTE LTD | 32 | Q3 2023 | 26.3% |
| TG THERAPEUTICS INC | 30 | Q4 2021 | 6.3% |
| ZOGENIX INC | 26 | Q4 2021 | 9.5% |
| BIOCRYST PHARMACEUTICALS | 23 | Q1 2019 | 9.2% |
| DICERNA PHARMACEUTICALS INC | 23 | Q3 2019 | 5.8% |
| RHYTHM PHARMACEUTICALS INC | 22 | Q3 2023 | 4.4% |
| ACHILLION PHARMACEUTICALS INC | 19 | Q4 2017 | 17.2% |
| KALA PHARMACEUTICALS INC | 19 | Q1 2022 | 4.4% |
| SOLID BIOSCIENCES INC | 19 | Q3 2022 | 6.8% |
View RA Capital Management's complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| CymaBay Therapeutics, Inc. | September 22, 2023 | 6,940,000 | 6.2% |
| BELLUS Health Inc.Sold out | August 14, 2023 | 0 | 0.0% |
| Kinnate Biopharma Inc.Sold out | August 14, 2023 | 0 | 0.0% |
| Vor Biopharma Inc. | August 11, 2023 | 22,780,343 | 33.7% |
| DICE Therapeutics, Inc.Sold out | August 09, 2023 | 0 | 0.0% |
| Acumen Pharmaceuticals, Inc. | July 25, 2023 | 14,981,618 | 25.9% |
| Talaris Therapeutics, Inc. | July 06, 2023 | 2,333,175 | 5.5% |
| Aerovate Therapeutics, Inc. | June 27, 2023 | 8,293,148 | 30.0% |
| Satsuma Pharmaceuticals, Inc.Sold out | June 12, 2023 | 0 | 0.0% |
| ARYA Sciences Acquisition Corp VSold out | May 15, 2023 | 0 | 0.0% |
View RA Capital Management's complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| SC 13G | 2024-04-25 |
| 4 | 2024-04-15 |
| 4 | 2024-04-15 |
| SC 13G | 2024-04-15 |
| SC 13D/A | 2024-04-12 |
| SC 13G | 2024-04-12 |
| SC 13D/A | 2024-04-11 |
| SC 13G | 2024-04-11 |
| 4 | 2024-04-04 |
| SC 13G | 2024-04-04 |
View RA Capital Management's complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.