$7.56 Billion is the total value of RA Capital Management's 79 reported holdings in Q2 2024. The portfolio turnover from Q1 2024 to Q2 2024 was 26.3% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/S - ADRsh | $1,378,583,592 | -9.8% | 10,108,400 | 0.0% | 18.23% | -6.2% | |
| PCVX | VAXCYTE INCsh | $619,465,465 | +10.5% | 8,203,754 | 0.0% | 8.19% | +14.9% | |
| JANX | JANUX THERAPEUTICS INCsh | $383,949,162 | +11.3% | 9,165,652 | 0.0% | 5.08% | +15.7% | |
| LEGN | Buy | LEGEND BIOTECH CORP-ADRsh | $332,482,107 | -13.6% | 7,506,934 | +9.4% | 4.40% | -10.2% |
| RYTM | Buy | RHYTHM PHARMACEUTICALS INCsh | $249,825,957 | +8.2% | 6,084,412 | +14.1% | 3.30% | +12.5% |
| BIIB | Buy | BIOGEN INCsh | $227,679,463 | +42.5% | 982,139 | +32.6% | 3.01% | +48.2% |
| Buy | ELIEM THERAPEUTICS INCsh | $223,390,988 | +520.0% | 31,419,267 | +138.9% | 2.96% | +545.2% | |
| Buy | RXSIGHT INCsh | $222,317,620 | +25.2% | 3,694,825 | +7.3% | 2.94% | +30.1% | |
| RNA | Buy | AVIDITY BIOSCIENCES INCsh | $220,606,667 | +163.4% | 5,400,408 | +64.5% | 2.92% | +173.7% |
| DYN | Buy | DYNE THERAPEUTICS INCsh | $213,476,409 | +51.8% | 6,049,204 | +22.1% | 2.82% | +57.7% |
| GERN | GERON CORPsh | $195,898,282 | +28.5% | 46,202,425 | 0.0% | 2.59% | +33.6% | |
| PEPGEN INCsh | $170,605,138 | +8.6% | 10,689,545 | 0.0% | 2.26% | +12.9% | ||
| TYRA BIOSCIENCES INCsh | $166,561,578 | -2.5% | 10,416,609 | 0.0% | 2.20% | +1.4% | ||
| EVH | Buy | EVOLENT HEALTH INC - Ash | $162,804,161 | -13.4% | 8,514,862 | +48.4% | 2.15% | -10.0% |
| EWTX | EDGEWISE THERAPEUTICS INCsh | $160,452,729 | -1.3% | 8,909,091 | 0.0% | 2.12% | +2.7% | |
| Buy | NEWAMSTERDAM PHARMA CO NVsh | $154,909,440 | -16.7% | 8,064,000 | +2.5% | 2.05% | -13.4% | |
| RXRX | New | RECURSION PHARMACEUTICALS-Ash | $115,384,613 | – | 15,384,615 | +100.0% | 1.53% | – |
| ETNB | Buy | 89BIO INCsh | $113,544,938 | -23.6% | 14,175,398 | +11.0% | 1.50% | -20.6% |
| VRNA | Buy | VERONA PHARMA PLC - ADRsh | $110,368,061 | +8.6% | 7,632,646 | +20.8% | 1.46% | +12.9% |
| DAWN | Buy | DAY ONE BIOPHARMACEUTICALS Ish | $108,472,315 | -15.9% | 7,871,721 | +0.8% | 1.44% | -12.6% |
| FDMT | Buy | 4D MOLECULAR THERAPEUTICS INsh | $107,011,449 | -33.5% | 5,098,211 | +0.9% | 1.42% | -30.9% |
| SBTX | ARS PHARMACEUTICALS INCsh | $92,426,914 | -16.7% | 10,860,977 | 0.0% | 1.22% | -13.5% | |
| WVE | WAVE LIFE SCIENCES LTDsh | $90,828,025 | -19.1% | 18,202,009 | 0.0% | 1.20% | -16.0% | |
| LBPH | LONGBOARD PHARMACEUTICALS INsh | $88,904,887 | +25.1% | 3,289,119 | 0.0% | 1.18% | +30.1% | |
| New | ARCELLX INCsh | $88,525,533 | – | 1,604,014 | +100.0% | 1.17% | – | |
| AXSM | AXSOME THERAPEUTICS INCsh | $80,500,000 | +0.9% | 1,000,000 | 0.0% | 1.06% | +4.9% | |
| Sell | APOGEE THERAPEUTICS INCsh | $77,199,309 | -41.3% | 1,961,863 | -0.8% | 1.02% | -38.9% | |
| GHRS | Buy | GH RESEARCH PLCsh | $76,975,694 | +15.5% | 6,601,689 | +5.6% | 1.02% | +20.0% |
| Buy | STRUCTURE THERAPEUTICS INCsh | $74,486,236 | +15.1% | 1,896,772 | +25.6% | 0.98% | +19.5% | |
| LENZ THERAPEUTICS INCsh | $72,251,850 | -22.6% | 4,178,823 | 0.0% | 0.96% | -19.5% | ||
| FULC | FULCRUM THERAPEUTICS INCsh | $71,980,165 | -34.3% | 11,609,704 | 0.0% | 0.95% | -31.7% | |
| NKTX | NKARTA INCsh | $63,858,312 | -45.3% | 10,805,129 | 0.0% | 0.84% | -43.1% | |
| DIANTHUS THERAPEUTICS INCsh | $60,378,040 | -13.7% | 2,333,000 | 0.0% | 0.80% | -10.2% | ||
| MINERALYS THERAPEUTICS INCsh | $56,756,513 | -9.4% | 4,850,984 | 0.0% | 0.75% | -5.8% | ||
| ITOS | Sell | ITEOS THERAPEUTICS INCsh | $52,196,124 | -13.4% | 3,517,259 | -20.4% | 0.69% | -10.0% |
| URGN | UROGEN PHARMA LTDsh | $51,739,955 | +11.9% | 3,083,430 | 0.0% | 0.68% | +16.3% | |
| Buy | PRAXIS PRECISION MEDICINES Ish | $51,104,375 | +1.1% | 1,235,599 | +49.2% | 0.68% | +5.1% | |
| ENLIVEN THERAPEUTICS INCsh | $49,602,007 | +32.9% | 2,122,465 | 0.0% | 0.66% | +38.1% | ||
| Buy | ACRIVON THERAPEUTICS INCsh | $48,374,946 | +40.6% | 8,340,508 | +73.4% | 0.64% | +46.1% | |
| Buy | ASTRIA THERAPEUTICS INCsh | $45,898,180 | -26.1% | 5,043,756 | +14.3% | 0.61% | -23.2% | |
| BCYC | Buy | BICYCLE THERAPEUTICS PLC-ADRsh | $45,600,720 | +128.9% | 2,253,000 | +181.6% | 0.60% | +138.3% |
| CG ONCOLOGY INCsh | $44,116,960 | -28.1% | 1,397,433 | 0.0% | 0.58% | -25.3% | ||
| LRMR | LARIMAR THERAPEUTICS INCsh | $43,828,795 | -4.5% | 6,045,351 | 0.0% | 0.58% | -0.7% | |
| ABOS | ACUMEN PHARMACEUTICALS INCsh | $36,135,592 | -40.2% | 14,932,063 | 0.0% | 0.48% | -37.8% | |
| New | TOURMALINE BIO INCsh | $32,650,576 | – | 2,538,925 | +100.0% | 0.43% | – | |
| THIRD HARMONIC BIO INCsh | $26,429,728 | +37.7% | 2,033,056 | 0.0% | 0.35% | +43.4% | ||
| SOLID BIOSCIENCES INCsh | $24,553,629 | -57.4% | 4,330,446 | 0.0% | 0.32% | -55.7% | ||
| TSHA | TAYSHA GENE THERAPIES INCsh | $24,354,407 | -22.0% | 10,872,503 | 0.0% | 0.32% | -18.9% | |
| Buy | TENAYA THERAPEUTICS INCsh | $23,629,276 | -21.5% | 7,622,347 | +32.4% | 0.31% | -18.3% | |
| VOR | VOR BIOPHARMA INCsh | $22,748,880 | -57.8% | 22,748,880 | 0.0% | 0.30% | -56.1% | |
| CCCC | C4 THERAPEUTICS INCsh | $22,536,360 | -43.5% | 4,878,000 | 0.0% | 0.30% | -41.2% | |
| Buy | ALTO NEUROSCIENCE INCsh | $22,294,572 | +4.8% | 2,085,554 | +50.5% | 0.30% | +8.9% | |
| IMTX | IMMATICS NVsh | $20,335,000 | +10.6% | 1,750,000 | 0.0% | 0.27% | +15.0% | |
| Buy | SERA PROGNOSTICS INC-Ash | $17,954,223 | -2.5% | 3,032,808 | +49.8% | 0.24% | +1.3% | |
| AVTE | Buy | AEROVATE THERAPEUTICS INCsh | $15,258,873 | -93.8% | 9,192,092 | +11.2% | 0.20% | -93.5% |
| HOWL | WEREWOLF THERAPEUTICS INCsh | $14,993,510 | -62.3% | 6,144,881 | 0.0% | 0.20% | -60.9% | |
| Sell | CERVOMED INCsh | $13,989,094 | -30.3% | 817,120 | -5.2% | 0.18% | -27.5% | |
| PLRX | PLIANT THERAPEUTICS INCsh | $13,770,750 | -27.9% | 1,281,000 | 0.0% | 0.18% | -25.1% | |
| NRIX | New | NURIX THERAPEUTICS INCsh | $13,565,500 | – | 650,000 | +100.0% | 0.18% | – |
| INSM | New | INSMED INCsh | $13,400,000 | – | 200,000 | +100.0% | 0.18% | – |
| CLXPF | Sell | CYBIN INCsh | $11,925,210 | -50.4% | 44,004,464 | -24.3% | 0.16% | -48.4% |
| AN2 THERAPEUTICS INCsh | $11,935,284 | -33.8% | 5,551,295 | 0.0% | 0.16% | -31.3% | ||
| New | ZURA BIO LTDsh | $11,261,261 | – | 3,217,503 | +100.0% | 0.15% | – | |
| REGULUS THERAPEUTICS INCsh | $11,156,250 | -38.0% | 6,250,000 | 0.0% | 0.15% | -35.4% | ||
| ARVN | ARVINAS INCsh | $11,216,284 | -35.5% | 421,348 | 0.0% | 0.15% | -33.0% | |
| Buy | LEXEO THERAPEUTICS INCsh | $10,790,300 | +4.1% | 672,712 | +1.8% | 0.14% | +8.3% | |
| ACET | ADICET BIO INCsh | $9,124,610 | -48.5% | 7,541,000 | 0.0% | 0.12% | -46.2% | |
| New | NUVALENT INC-Ash | $9,087,194 | – | 119,789 | +100.0% | 0.12% | – | |
| MGNX | MACROGENICS INCsh | $8,848,589 | -71.1% | 2,082,021 | 0.0% | 0.12% | -70.0% | |
| BOUNDLESS BIO INCsh | $8,439,042 | -72.8% | 2,180,631 | 0.0% | 0.11% | -71.6% | ||
| CMRX | CHIMERIX INCsh | $7,708,800 | -17.4% | 8,800,000 | 0.0% | 0.10% | -14.3% | |
| New | PERCEPTIVE CAPITAL SOLUTIONSsh | $7,545,000 | – | 750,000 | +100.0% | 0.10% | – | |
| Sell | METAGENOMI INCsh | $6,029,216 | -67.2% | 1,477,749 | -15.3% | 0.08% | -65.8% | |
| TARA | New | PROTARA THERAPEUTIC INCsh | $3,952,000 | – | 1,900,000 | +100.0% | 0.05% | – |
| New | SURROZEN INCsh | $3,094,251 | – | 282,580 | +100.0% | 0.04% | – | |
| NEWAMSTERDAM PHARMA CO NV-27sh | $2,906,664 | -21.0% | 333,333 | 0.0% | 0.04% | -19.1% | ||
| Sell | UNICYCIVE THERAPEUTICS INCsh | $1,318,995 | -72.5% | 2,632,200 | -24.2% | 0.02% | -72.1% | |
| New | SCILEX HOLDING COsh | $504,075 | – | 261,179 | +100.0% | 0.01% | – | |
| CVAC | Exit | CUREVAC NVsh | $0 | – | -1,965,707 | -100.0% | -0.08% | – |
| CMPS | Exit | COMPASS PATHWAYS PLCsh | $0 | – | -791,359 | -100.0% | -0.08% | – |
| IGMS | Exit | IGM BIOSCIENCES INCsh | $0 | – | -937,500 | -100.0% | -0.12% | – |
| BDTX | Exit | BLACK DIAMOND THERAPEUTICS Ish | $0 | – | -3,525,754 | -100.0% | -0.23% | – |
| EYPT | Exit | EYEPOINT PHARMACEUTICALS INCsh | $0 | – | -938,591 | -100.0% | -0.25% | – |
| VXRT | Exit | VAXART INCsh | $0 | – | -15,384,615 | -100.0% | -0.25% | – |
| Exit | CYTEK BIOSCIENCES INCsh | $0 | – | -6,809,404 | -100.0% | -0.58% | – | |
| MDGL | Exit | MADRIGAL PHARMACEUTICALS INCsh | $0 | – | -204,500 | -100.0% | -0.70% | – |
| INBX | Exit | INHIBRX INCsh | $0 | – | -2,629,837 | -100.0% | -1.17% | – |
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2024-08-14
About RA Capital Management
RA Capital Management is a Boston-based investment management firm that specializes in the healthcare sector. The firm was founded in 2001 by Peter Kolchinsky, a former biotech analyst at Lehman Brothers. Since then, RA Capital has grown to become one of the most respected healthcare investment firms in the world, with over $5 billion in assets under management.
The firm's investment strategy is focused on identifying and investing in companies that are developing innovative therapies and technologies that have the potential to transform the healthcare industry. RA Capital's team of experienced analysts and portfolio managers conduct extensive research and due diligence to identify the most promising investment opportunities in the healthcare sector.
RA Capital's portfolio includes a diverse range of companies, from early-stage startups to established biotech and pharmaceutical companies. Some of the notable companies in RA Capital's portfolio include Moderna, a biotech company that is developing a COVID-19 vaccine, and Intellia Therapeutics, a gene editing company that is developing therapies for genetic diseases.
Peter Kolchinsky, the founder and CEO of RA Capital, is a well-respected figure in the healthcare investment community. He is a frequent speaker at industry conferences and has authored several books on biotech investing. Other key members of RA Capital's management team include Rajeev Shah, the firm's COO, and Derek DiRocco, the Chief Investment Officer.
Overall, RA Capital Management is a highly respected investment firm that has a proven track record of identifying and investing in innovative healthcare companies. Investors who are interested in the healthcare sector may want to consider RA Capital as a potential investment opportunity.
It's important to note that this information is for educational purposes only and has not been fact-checked. As with any investment, it's important to do your own research and consult with a financial advisor before making any investment decisions.
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| ASCENDIS PHARMA A/S - ADR | 38 | Q2 2024 | 25.5% |
| WAVE LIFE SCIENCES PTE LTD | 35 | Q2 2024 | 26.3% |
| TG THERAPEUTICS INC | 30 | Q4 2021 | 6.3% |
| ZOGENIX INC | 26 | Q4 2021 | 9.5% |
| RHYTHM PHARMACEUTICALS INC | 25 | Q2 2024 | 4.4% |
| BIOCRYST PHARMACEUTICALS | 23 | Q1 2019 | 9.2% |
| DICERNA PHARMACEUTICALS INC | 23 | Q3 2019 | 5.8% |
| ACHILLION PHARMACEUTICALS INC | 19 | Q4 2017 | 17.2% |
| 89BIO INC | 19 | Q2 2024 | 4.1% |
| KALA PHARMACEUTICALS INC | 19 | Q1 2022 | 4.4% |
View RA Capital Management's complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Perceptive Capital Solutions Corp | June 24, 2024 | 750,000 | 8.4% |
| Aerovate Therapeutics, Inc. | June 20, 2024 | 9,242,092 | 32.0% |
| Evolent Health, Inc. | June 17, 2024 | 8,279,103 | 7.1% |
| Solid Biosciences Inc. | June 12, 2024 | 4,358,478 | 11.3% |
| BICYCLE THERAPEUTICS plc | June 07, 2024 | 2,253,000 | 5.0% |
| Tourmaline Bio, Inc. | June 03, 2024 | 2,045,028 | 8.0% |
| Structure Therapeutics Inc. | May 30, 2024 | 7,225,311 | 5.2% |
| iTeos Therapeutics, Inc. | May 14, 2024 | 3,659,046 | 10.0% |
| Medicenna Therapeutics Corp. | May 10, 2024 | 7,714,760 | 10.0% |
| Black Diamond Therapeutics, Inc. | May 09, 2024 | 2,788,028 | 5.0% |
View RA Capital Management's complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| SC 13D | 2024-11-04 |
| SC 13G | 2024-10-31 |
| 4 | 2024-10-30 |
| 3 | 2024-10-24 |
| 4 | 2024-10-22 |
| 4 | 2024-10-22 |
| SC 13D/A | 2024-10-22 |
| SC 13D/A | 2024-10-22 |
| SC 13G | 2024-10-07 |
| SC 13D/A | 2024-10-01 |
View RA Capital Management's complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.