RA Capital Management Activity Q4 2007-Q3 2023

Q3 2023

			Value		Shares		↓ Weighting
ASND	Sell	ASCENDIS PHARMA A/S - ADR	$1,003,779,130	+0.2%	10,719,555	-4.5%	19.76%	+4.5%
IMGN	Buy	IMMUNOGEN INC	$211,424,711	+380.9%	13,322,288	+471.8%	4.16%	+401.4%
CBAY	New	CYMABAY THERAPEUTICS INC	$103,475,400	–	6,940,000	–	2.04%	–
GERN	Buy	GERON CORP	$97,949,141	-3.3%	46,202,425	+46.5%	1.93%	+0.8%
JANX	Buy	JANUX THERAPEUTICS INC	$92,389,772	-10.2%	9,165,652	+5.7%	1.82%	-6.4%
	Buy	AN2 THERAPEUTICS INC	$89,264,824	+178.3%	5,551,295	+47.1%	1.76%	+189.9%
INBX	Buy	INHIBRX INCsh	$86,689,198	-13.4%	4,724,207	+22.6%	1.71%	-9.6%
EVH	New	EVOLENT HEALTH INC - A	$74,519,796	–	2,736,680	–	1.47%	–
CVAC	Sell	CUREVAC NV	$72,427,670	-43.2%	10,604,344	-13.4%	1.43%	-40.8%
ABOS	Buy	ACUMEN PHARMACEUTICALS INC	$61,968,061	+31.9%	14,932,063	+52.8%	1.22%	+37.5%
TSHA	New	TAYSHA GENE THERAPIES INC	$58,373,109	–	18,472,503	–	1.15%	–
FDMT	Buy	4D MOLECULAR THERAPEUTICS IN	$52,997,676	-4.5%	4,163,211	+35.6%	1.04%	-0.4%
	New	APOGEE THERAPEUTICS INC	$42,129,291	–	1,977,901	–	0.83%	–
	Sell	CYTEK BIOSCIENCES INC	$37,587,910	-64.2%	6,809,404	-44.6%	0.74%	-62.7%
	New	SOLENO THERAPEUTICS INC	$36,562,890	–	1,239,000	–	0.72%	–
SBTX	Buy	ARS PHARMACEUTICALS INC	$35,757,583	+77.3%	9,459,678	+214.3%	0.70%	+84.8%
MDGL	New	MADRIGAL PHARMACEUTICALS INC	$29,865,180	–	204,500	–	0.59%	–
URGN	New	UROGEN PHARMA LTD	$20,786,595	–	1,483,697	–	0.41%	–
	Buy	TENAYA THERAPEUTICS INC	$17,132,132	-51.9%	6,718,483	+10.7%	0.34%	-49.9%
BCYC	New	BICYCLE THERAPEUTICS PLC-ADRsponsored adr	$16,072,000	–	800,000	–	0.32%	–
NKTR	New	NEKTAR THERAPEUTICS	$11,137,720	–	18,700,000	–	0.22%	–
CMPS	New	COMPASS PATHWAYS PLC	$9,516,400	–	1,286,000	–	0.19%	–
TALS	Buy	TALARIS THERAPEUTICS INC	$6,753,099	-4.8%	2,403,238	+3.0%	0.13%	-0.7%
CMRX	New	CHIMERIX INC	$6,240,259	–	6,501,624	–	0.12%	–
	New	THIRD HARMONIC BIO INC	$6,146,305	–	961,863	–	0.12%	–
	New	UNICYCIVE THERAPEUTICS INC	$2,984,792	–	3,470,688	–	0.06%	–
MGNX	New	MACROGENICS INC	$1,593,720	–	342,000	–	0.03%	–
DSGN	Exit	DESIGN THERAPEUTICS INC	$0	–	-2,971,231	–	-0.35%	–
	Exit	DICE THERAPEUTICS INC	$0	–	-7,856,612	–	-6.89%	–

Q2 2023

			Value		Shares		↓ Weighting
ASND	New	ASCENDIS PHARMA A/S	$1,001,863,112	–	11,225,357	–	18.92%	–
LEGN	New	LEGEND BIOTECH CORP	$432,452,724	–	6,264,707	–	8.16%	–
PCVX	New	VAXCYTE INCsponsored ads	$394,089,225	–	7,891,254	–	7.44%	–
	New	DICE THERAPEUTICS INC	$365,018,194	–	7,856,612	–	6.89%	–
ETNB	New	89BIO INC	$216,351,165	–	11,416,948	–	4.08%	–
BIIB	New	BIOGEN INCsponsored adr	$151,794,286	–	532,892	–	2.87%	–
AVTE	New	AEROVATE THERAPEUTICS INC	$141,727,291	–	8,263,982	–	2.68%	–
VRNA	New	VERONA PHARMA PLC	$133,562,309	–	6,317,990	–	2.52%	–
CVAC	New	CUREVAC N V	$127,602,851	–	12,245,955	–	2.41%	–
	New	TYRA BIOSCIENCES INC	$123,236,812	–	7,236,454	–	2.33%	–
	New	NEWAMSTERDAM PHARMA COMPANY	$107,010,000	–	9,000,000	–	2.02%	–
	New	CYTEK BIOSCIENCES INC	$105,022,537	–	12,297,721	–	1.98%	–
JANX	New	JANUX THERAPEUTICS INC	$102,920,544	–	8,670,644	–	1.94%	–
GERN	New	GERON CORP	$101,258,827	–	31,544,806	–	1.91%	–
INBX	New	INHIBRX INC	$100,046,387	–	3,853,867	–	1.89%	–
RYTM	New	RHYTHM PHARMACEUTICALS INC	$93,598,345	–	5,676,067	–	1.77%	–
DAWN	New	DAY ONE BIOPHARMACEUTICALS I	$93,249,633	–	7,809,852	–	1.76%	–
	New	RXSIGHT INC	$87,920,525	–	3,052,796	–	1.66%	–
COGT	New	COGENT COMMUNICATIONS HLDGS	$75,967,180	–	6,416,147	–	1.43%	–
	New	PEPGEN INC	$72,699,651	–	8,131,952	–	1.37%	–
AXSM	New	AXSOME THERAPEUTICS INC	$71,860,000	–	1,000,000	–	1.36%	–
RNA	New	AVIDITY BIOSCIENCES INC	$71,164,508	–	6,416,998	–	1.34%	–
VOR	New	VOR BIOPHARMA INC	$70,294,039	–	22,748,880	–	1.33%	–
GHRS	New	GH RESEARCH PLCsponsored adr	$66,293,706	–	5,587,333	–	1.25%	–
WVE	New	WAVE LIFE SCIENCES LTD	$62,615,313	–	17,202,009	–	1.18%	–
	New	ACRIVON THERAPEUTICS INC	$62,344,184	–	4,810,508	–	1.18%	–
	New	ICOSAVAX INC	$59,218,200	–	5,963,565	–	1.12%	–
ITOS	New	ITEOS THERAPEUTICS INC	$58,484,509	–	4,417,259	–	1.10%	–
FDMT	New	4D MOLECULAR THERAPEUTICS IN	$55,466,425	–	3,069,531	–	1.05%	–
	New	MINERALYS THERAPEUTICS INC	$54,193,016	–	3,178,476	–	1.02%	–
ALPN	New	ALPINE IMMUNE SCIENCES INC	$48,225,310	–	4,691,178	–	0.91%	–
VRDN	New	VIRIDIAN THERAPEUTICS INC	$47,769,035	–	2,007,946	–	0.90%	–
ABOS	New	ACUMEN PHARMACEUTICALS INC	$46,997,418	–	9,770,773	–	0.89%	–
ACRS	New	ACLARIS THERAPEUTICS INCsponsored ads	$45,611,958	–	4,398,453	–	0.86%	–
IMGN	New	IMMUNOGEN INC	$43,966,307	–	2,329,958	–	0.83%	–
	New	ENLIVEN THERAPEUTICS INC	$43,319,511	–	2,122,465	–	0.82%	–
FULC	New	FULCRUM THERAPEUTICS INC	$38,312,023	–	11,609,704	–	0.72%	–
	New	ELIEM THERAPEUTICS INCads	$36,822,377	–	13,150,849	–	0.70%	–
	New	TENAYA THERAPEUTICS INC	$35,616,125	–	6,067,483	–	0.67%	–
	New	AN2 THERAPEUTICS INC	$32,074,895	–	3,773,517	–	0.61%	–
PLRX	New	PLIANT THERAPEUTICS INC	$31,927,440	–	1,762,000	–	0.60%	–
EYPT	New	EYEPOINT PHARMACEUTICALS INC	$29,323,402	–	3,370,506	–	0.55%	–
SBTX	New	ARS PHARMACEUTICALS INC	$20,164,843	–	3,009,678	–	0.38%	–
HOWL	New	WEREWOLF THERAPEUTICS INC	$18,741,887	–	6,144,881	–	0.35%	–
DSGN	New	DESIGN THERAPEUTICS INC	$18,718,755	–	2,971,231	–	0.35%	–
	New	SOLID BIOSCIENCES INC	$17,953,739	–	3,426,286	–	0.34%	–
BDTX	New	BLACK DIAMOND THERAPEUTICS I	$17,805,058	–	3,525,754	–	0.34%	–
NKTX	New	NKARTA INC	$17,093,233	–	7,805,129	–	0.32%	–
CELC	New	CELCUITY INC	$15,372,011	–	1,400,001	–	0.29%	–
IGMS	New	IGM BIOSCIENCES INC	$8,653,125	–	937,500	–	0.16%	–
CNTB	New	CONNECT BIOPHARMA HLDGS LTD	$7,899,833	–	6,991,003	–	0.15%	–
TALS	New	TALARIS THERAPEUTICS INC	$7,092,852	–	2,333,175	–	0.13%	–
NSTG	New	NANOSTRING TECHNOLOGIESordinary shares	$6,979,661	–	1,723,373	–	0.13%	–
	New	NEWAMSTERDAM PHARMA COMPANY	$696,666	–	333,333	–	0.01%	–

Q4 2022

			Value		Shares		↓ Weighting
AGLE	Exit	AEGLEA BIOTHERAPEUTICS INC	$0	–	-10,439	–	0.00%	–
APTX	Exit	APTINYX INC	$0	–	-1,954,698	–	-0.02%	–
BOLT	Exit	BOLT BIOTHERAPEUTICS INC	$0	–	-533,432	–	-0.02%	–
SNSE	Exit	SENSEI BIOTHERAPEUTICS	$0	–	-683,529	–	-0.02%	–
	Exit	PYXIS ONCOLOGY INC	$0	–	-764,653	–	-0.03%	–
FUSN	Exit	FUSION PHARMACEUTICALS INC	$0	–	-659,992	–	-0.04%	–
ENTX	Exit	ENTERA BIO LTD	$0	–	-2,082,372	–	-0.05%	–
CVRX	Exit	CVRX INC	$0	–	-275,000	–	-0.06%	–
BDTX	Exit	BLACK DIAMOND THERAPEUTICS I	$0	–	-2,589,904	–	-0.09%	–
SYBX	Exit	SYNLOGIC INC	$0	–	-4,618,415	–	-0.09%	–
	Exit	TENAYA THERAPEUTICS INC	$0	–	-1,602,009	–	-0.10%	–
	Exit	IO BIOTECH INC	$0	–	-1,857,755	–	-0.11%	–
MGTA	Exit	MAGENTA THERAPEUTICS INC	$0	–	-3,588,081	–	-0.11%	–
ATHA	Exit	ATHIRA PHARMA INC	$0	–	-1,878,000	–	-0.12%	–
SLDB	Exit	SOLID BIOSCIENCES INC	$0	–	-12,367,873	–	-0.12%	–
HSAQ	Exit	HEALTH SCIENCES ACQ CORP 2	$0	–	-610,283	–	-0.13%	–
DBVT	Exit	DBV TECHNOLOGIES S Asponsored adr	$0	–	-3,724,740	–	-0.14%	–
CNCE	Exit	CONCERT PHARMACEUTICALS INC	$0	–	-1,088,296	–	-0.16%	–
FVAM	Exit	5 01 ACQUISITION CORP	$0	–	-750,000	–	-0.16%	–
	Exit	AADI BIOSCIENCE INC	$0	–	-590,218	–	-0.18%	–
CNTB	Exit	CONNECT BIOPHARMA HLDGS LTDads	$0	–	-6,991,003	–	-0.19%	–
	Exit	ARYA SCIENCES ACQUISITN CORP	$0	–	-1,000,000	–	-0.21%	–
FLACU	Exit	FRAZIER LIFESCIENCES ACQU CO	$0	–	-1,000,000	–	-0.21%	–
ACHL	Exit	ACHILLES THERAPEUTICS PLCsponsored ads	$0	–	-5,014,687	–	-0.24%	–
	Exit	PARDES BIOSCIENCES INC	$0	–	-6,175,038	–	-0.24%	–
BLSA	Exit	BCLS ACQUISITION CORP	$0	–	-1,250,000	–	-0.27%	–
	Exit	DA32 LIFE SCNCE	$0	–	-1,500,000	–	-0.31%	–
RLAY	Exit	RELAY THERAPEUTICS INC	$0	–	-717,618	–	-0.34%	–
VRDN	Exit	VIRIDIAN THERAPEUTICS INCsponsored ads	$0	–	-880,000	–	-0.38%	–
	Exit	ICOSAVAX INC	$0	–	-5,963,565	–	-0.40%	–
HOWL	Exit	WEREWOLF THERAPEUTICS INC	$0	–	-4,291,881	–	-0.41%	–
PMVP	Exit	PMV PHARMACEUTICALS INC	$0	–	-1,710,265	–	-0.43%	–
MIST	Exit	MILESTONE PHARMACEUTICALS IN	$0	–	-2,246,503	–	-0.44%	–
EYPT	Exit	EYEPOINT PHARMACEUTICALS INC	$0	–	-3,370,506	–	-0.57%	–
ACET	Exit	ADICET BIO INC	$0	–	-2,059,372	–	-0.62%	–
	Exit	HILLEVAX INC	$0	–	-1,760,019	–	-0.64%	–
ALPN	Exit	ALPINE IMMUNE SCIENCES INC	$0	–	-4,356,632	–	-0.67%	–
AKRO	Exit	AKERO THERAPEUTICS INC	$0	–	-958,980	–	-0.70%	–
RCKT	Exit	ROCKET PHARMACEUTICALS INC	$0	–	-2,107,149	–	-0.72%	–
VERA	Exit	VERA THERAPEUTICS INCcl a	$0	–	-1,578,820	–	-0.72%	–
RNA	Exit	AVIDITY BIOSCIENCES INC	$0	–	-2,167,391	–	-0.76%	–
STSA	Exit	SATSUMA PHARMACEUTICALS INC	$0	–	-5,914,252	–	-0.76%	–
	Exit	RXSIGHT INC	$0	–	-3,052,796	–	-0.78%	–
TIL	Exit	INSTIL BIO INC	$0	–	-7,670,793	–	-0.79%	–
	Exit	ELIEM THERAPEUTICS INC	$0	–	-13,150,849	–	-0.91%	–
VOR	Exit	VOR BIOPHARMA INC	$0	–	-11,120,973	–	-0.94%	–
ETNB	Exit	89BIO INC	$0	–	-7,782,669	–	-0.96%	–
DSGN	Exit	DESIGN THERAPEUTICS INC	$0	–	-2,773,231	–	-0.99%	–
ENTA	Exit	ENANTA PHARMACEUTICALS INC	$0	–	-896,724	–	-0.99%	–
KNTE	Exit	KINNATE BIOPHARMA INC	$0	–	-4,264,144	–	-1.09%	–
FULC	Exit	FULCRUM THERAPEUTICS INC	$0	–	-7,000,000	–	-1.21%	–
GHRS	Exit	GH RESEARCH PLCordinary shares	$0	–	-4,898,373	–	-1.21%	–
CLDX	Exit	CELLDEX THERAPEUTICS INC NEW	$0	–	-2,075,000	–	-1.24%	–
NSTG	Exit	NANOSTRING TECHNOLOGIES	$0	–	-4,602,478	–	-1.25%	–
COGT	Exit	COGENT COMMUNICATIONS HLDGS	$0	–	-4,013,453	–	-1.28%	–
VRNA	Exit	VERONA PHARMA PLCsponsored ads	$0	–	-6,050,000	–	-1.32%	–
WVE	Exit	WAVE LIFE SCIENCES LTD	$0	–	-17,202,009	–	-1.32%	–
	Exit	TYRA BIOSCIENCES INC	$0	–	-7,236,454	–	-1.36%	–
	Exit	AN2 THERAPEUTICS INC	$0	–	-3,773,517	–	-1.40%	–
	Exit	THIRD HARMONIC BIO INC	$0	–	-3,475,687	–	-1.41%	–
ACRS	Exit	ACLARIS THERAPEUTICS INC	$0	–	-4,398,453	–	-1.48%	–
GERN	Exit	GERON CORP	$0	–	-30,126,299	–	-1.50%	–
	Exit	PEPGEN INC	$0	–	-8,131,952	–	-1.58%	–
RLMD	Exit	RELMADA THERAPEUTICS INC	$0	–	-2,000,000	–	-1.58%	–
ITOS	Exit	ITEOS THERAPEUTICS INC	$0	–	-4,417,259	–	-1.80%	–
LEGN	Exit	LEGEND BIOTECH CORPsponsored ads	$0	–	-2,338,610	–	-2.04%	–
ABOS	Exit	ACUMEN PHARMACEUTICALS INC	$0	–	-9,770,773	–	-2.09%	–
NKTX	Exit	NKARTA INC	$0	–	-7,805,129	–	-2.19%	–
IMGN	Exit	IMMUNOGEN INC	$0	–	-21,741,458	–	-2.22%	–
	Exit	DICE THERAPEUTICS INC	$0	–	-5,208,911	–	-2.25%	–
PCVX	Exit	VAXCYTE INC	$0	–	-4,581,203	–	-2.35%	–
JANX	Exit	JANUX THERAPEUTICS INC	$0	–	-8,670,644	–	-2.50%	–
BLU	Exit	BELLUS HEALTH INC NEW	$0	–	-11,385,574	–	-2.56%	–
TVTX	Exit	TRAVERE THERAPEUTICS INC	$0	–	-4,922,941	–	-2.59%	–
RYTM	Exit	RHYTHM PHARMACEUTICALS INC	$0	–	-5,471,067	–	-2.86%	–
AVTE	Exit	AEROVATE THERAPEUTICS INC	$0	–	-8,263,982	–	-2.92%	–
DAWN	Exit	DAY ONE BIOPHARMACEUTICALS I	$0	–	-7,040,622	–	-3.01%	–
FMTX	Exit	FORMA THERAPEUTICS HLDGS INC	$0	–	-9,011,651	–	-3.84%	–
	Exit	CYTEK BIOSCIENCES INC	$0	–	-13,381,054	–	-4.20%	–
BIIB	Exit	BIOGEN INC	$0	–	-937,549	–	-5.34%	–
ASND	Exit	ASCENDIS PHARMA A/Ssponsored adr	$0	–	-7,567,900	–	-16.67%	–

Q3 2022

			Value		Shares		↓ Weighting
BIIB	Buy	BIOGEN INC	$250,325,000	+68.8%	937,549	+29.0%	5.34%	+35.1%
RYTM	Buy	RHYTHM PHARMACEUTICALS INC	$134,041,000	+563.1%	5,471,067	+12.3%	2.86%	+430.6%
BLU	Buy	BELLUS HEALTH INC NEW	$120,232,000	+27.2%	11,385,574	+11.3%	2.56%	+1.8%
LEGN	New	LEGEND BIOTECH CORPsponsored ads	$95,415,000	–	2,338,610	–	2.04%	–
	New	THIRD HARMONIC BIO INC	$65,934,000	–	3,475,687	–	1.41%	–
	Buy	AN2 THERAPEUTICS INC	$65,584,000	+125.8%	3,773,517	+0.7%	1.40%	+80.5%
VRNA	Buy	VERONA PHARMA PLCsponsored ads	$61,831,000	+189.3%	6,050,000	+18.6%	1.32%	+131.4%
COGT	New	COGENT COMMUNICATIONS HLDGS	$59,881,000	–	4,013,453	–	1.28%	–
NSTG	Buy	NANOSTRING TECHNOLOGIES	$58,774,000	+29.1%	4,602,478	+28.4%	1.25%	+3.3%
FULC	New	FULCRUM THERAPEUTICS INC	$56,630,000	–	7,000,000	–	1.21%	–
DSGN	Buy	DESIGN THERAPEUTICS INC	$46,368,000	+51.5%	2,773,231	+26.8%	0.99%	+21.2%
AKRO	New	AKERO THERAPEUTICS INC	$32,653,000	–	958,980	–	0.70%	–
ALPN	New	ALPINE IMMUNE SCIENCES INC	$31,368,000	–	4,356,632	–	0.67%	–
ACET	New	ADICET BIO INC	$29,284,000	–	2,059,372	–	0.62%	–
VRDN	New	VIRIDIAN THERAPEUTICS INCsponsored ads	$18,049,000	–	880,000	–	0.38%	–
RLAY	Buy	RELAY THERAPEUTICS INC	$16,053,000	+74.5%	717,618	+30.7%	0.34%	+39.6%
	Buy	AADI BIOSCIENCE INC	$8,340,000	+76.7%	590,218	+54.1%	0.18%	+41.3%
CNCE	Sell	CONCERT PHARMACEUTICALS INC	$7,292,000	-47.6%	1,088,296	-67.1%	0.16%	-58.0%
DBVT	New	DBV TECHNOLOGIES S Asponsored adr	$6,593,000	–	3,724,740	–	0.14%	–
HSAQ	Sell	HEALTH SCIENCES ACQ CORP 2	$6,042,000	-2.9%	610,283	-2.4%	0.13%	-22.3%
MGTA	New	MAGENTA THERAPEUTICS INC	$5,059,000	–	3,588,081	–	0.11%	–
	Sell	TENAYA THERAPEUTICS INC	$4,646,000	-76.8%	1,602,009	-54.9%	0.10%	-81.4%
SYBX	Sell	SYNLOGIC INC	$4,387,000	-34.5%	4,618,415	-20.7%	0.09%	-47.5%
ENTX	Sell	ENTERA BIO LTD	$2,166,000	-30.8%	2,082,372	-11.5%	0.05%	-44.6%
FUSN	New	FUSION PHARMACEUTICALS INC	$1,987,000	–	659,992	–	0.04%	–
	Sell	PYXIS ONCOLOGY INC	$1,506,000	-33.6%	764,653	-19.8%	0.03%	-46.7%
SNSE	Sell	SENSEI BIOTHERAPEUTICS	$1,059,000	-35.5%	683,529	-5.5%	0.02%	-47.7%
BOLT	Buy	BOLT BIOTHERAPEUTICS INC	$789,000	-14.1%	533,432	+18.5%	0.02%	-29.2%
APTX	New	APTINYX INC	$720,000	–	1,954,698	–	0.02%	–
AGLE	New	AEGLEA BIOTHERAPEUTICS INC	$5,000	–	10,439	–	0.00%	–
CLBS	Exit	CALADRIUS BIOSCIENCES	$0	–	-752,500	–	-0.01%	–
AVRO	Exit	AVROBIO INC	$0	–	-559,600	–	-0.01%	–
OLMA	Exit	OLEMA PHARMACEUTICALS INC	$0	–	-233,793	–	-0.02%	–
ORTX	Exit	ORCHARD THERAPEUTICS PLCads	$0	–	-3,040,885	–	-0.05%	–
LRMR	Exit	LARIMAR THERAPEUTICS INC	$0	–	-1,031,482	–	-0.05%	–
ADVM	Exit	ADVERUM BIOTECHNOLOGIES INC	$0	–	-1,726,019	–	-0.06%	–
	Exit	ASTRIA THERAPEUTICS INC	$0	–	-760,857	–	-0.06%	–
BCAB	Exit	BIOATLA INC	$0	–	-1,031,805	–	-0.08%	–
TERN	Exit	TERNS PHARMACEUTICALS INC	$0	–	-1,261,435	–	-0.08%	–
FLDM	Exit	STANDARD BIOTOOLS INC	$0	–	-1,987,589	–	-0.08%	–
	Exit	XILIO THERAPEUTICS INC	$0	–	-1,649,711	–	-0.13%	–
BMEA	Exit	BIOMEA FUSION INC	$0	–	-500,000	–	-0.16%	–
IPSC	Exit	CENTURY THERAPEUTICS INC	$0	–	-756,821	–	-0.17%	–
	Exit	LIANBIOsponsored ads	$0	–	-4,622,574	–	-0.27%	–
OTIC	Exit	OTONOMY INC	$0	–	-5,600,000	–	-0.31%	–
GH	Exit	GUARDANT HEALTH INC	$0	–	-476,380	–	-0.51%	–
DYN	Exit	DYNE THERAPEUTICS INC	$0	–	-2,805,045	–	-0.51%	–
NTRA	Exit	NATERA INC	$0	–	-1,310,289	–	-1.24%	–
PNT	Exit	POINT BIOPHARMA GLOBAL INC	$0	–	-9,003,018	–	-1.64%	–
VERU	Exit	VERU INC	$0	–	-7,900,000	–	-2.38%	–

Q2 2022

			Value		Shares		↓ Weighting
ASND	New	ASCENDIS PHARMA A/Ssponsored adr	$703,512,000	–	7,567,900	–	18.76%	–
BIIB	New	BIOGEN INC	$148,269,000	–	727,024	–	3.95%	–
	New	CYTEK BIOSCIENCES INC	$143,578,000	–	13,381,054	–	3.83%	–
AVTE	New	AEROVATE THERAPEUTICS INC	$129,166,000	–	8,263,982	–	3.44%	–
DAWN	New	DAY ONE BIOPHARMACEUTICALS I	$126,027,000	–	7,040,622	–	3.36%	–
TVTX	New	TRAVERE THERAPEUTICS INC	$119,283,000	–	4,922,941	–	3.18%	–
JANX	New	JANUX THERAPEUTICS INC	$105,869,000	–	8,670,644	–	2.82%	–
PCVX	New	VAXCYTE INC	$99,687,000	–	4,581,203	–	2.66%	–
IMGN	New	IMMUNOGEN INC	$97,837,000	–	21,741,458	–	2.61%	–
NKTX	New	NKARTA INC	$96,159,000	–	7,805,129	–	2.56%	–
BLU	New	BELLUS HEALTH INC NEW	$94,528,000	–	10,230,274	–	2.52%	–
ITOS	New	ITEOS THERAPEUTICS INC	$90,996,000	–	4,417,259	–	2.43%	–
VERU	New	VERU INC	$89,270,000	–	7,900,000	–	2.38%	–
	New	DICE THERAPEUTICS INC	$80,842,000	–	5,208,911	–	2.16%	–
	New	PEPGEN INC	$80,750,000	–	8,131,952	–	2.15%	–
FMTX	New	FORMA THERAPEUTICS HLDGS INC	$62,090,000	–	9,011,651	–	1.66%	–
ACRS	New	ACLARIS THERAPEUTICS INC	$61,403,000	–	4,398,453	–	1.64%	–
PNT	New	POINT BIOPHARMA GLOBAL INC	$61,311,000	–	9,003,018	–	1.64%	–
CLDX	New	CELLDEX THERAPEUTICS INC NEW	$55,942,000	–	2,075,000	–	1.49%	–
WVE	New	WAVE LIFE SCIENCES LTD	$55,907,000	–	17,202,009	–	1.49%	–
VOR	New	VOR BIOPHARMA INC	$55,271,000	–	11,120,973	–	1.47%	–
KNTE	New	KINNATE BIOPHARMA INC	$53,771,000	–	4,264,144	–	1.43%	–
	New	TYRA BIOSCIENCES INC	$51,741,000	–	7,236,454	–	1.38%	–
GHRS	New	GH RESEARCH PLCordinary shares	$48,886,000	–	4,898,373	–	1.30%	–
GERN	New	GERON CORP	$46,696,000	–	30,126,299	–	1.24%	–
NTRA	New	NATERA INC	$46,437,000	–	1,310,289	–	1.24%	–
ABOS	New	ACUMEN PHARMACEUTICALS INC	$45,923,000	–	9,770,773	–	1.22%	–
NSTG	New	NANOSTRING TECHNOLOGIES	$45,523,000	–	3,584,478	–	1.21%	–
	New	RXSIGHT INC	$42,983,000	–	3,052,796	–	1.15%	–
ENTA	New	ENANTA PHARMACEUTICALS INC	$42,389,000	–	896,724	–	1.13%	–
	New	ELIEM THERAPEUTICS INC	$39,716,000	–	13,150,849	–	1.06%	–
RLMD	New	RELMADA THERAPEUTICS INC	$37,980,000	–	2,000,000	–	1.01%	–
TIL	New	INSTIL BIO INC	$35,439,000	–	7,670,793	–	0.94%	–
	New	ICOSAVAX INC	$34,172,000	–	5,963,565	–	0.91%	–
RNA	New	AVIDITY BIOSCIENCES INC	$31,492,000	–	2,167,391	–	0.84%	–
DSGN	New	DESIGN THERAPEUTICS INC	$30,613,000	–	2,186,636	–	0.82%	–
	New	AN2 THERAPEUTICS INC	$29,050,000	–	3,748,389	–	0.78%	–
RCKT	New	ROCKET PHARMACEUTICALS INC	$28,994,000	–	2,107,149	–	0.77%	–
EYPT	New	EYEPOINT PHARMACEUTICALS INC	$26,526,000	–	3,370,506	–	0.71%	–
ETNB	New	89BIO INC	$25,060,000	–	7,782,669	–	0.67%	–
STSA	New	SATSUMA PHARMACEUTICALS INC	$24,485,000	–	5,914,252	–	0.65%	–
PMVP	New	PMV PHARMACEUTICALS INC	$24,371,000	–	1,710,265	–	0.65%	–
VERA	New	VERA THERAPEUTICS INCcl a	$21,488,000	–	1,578,820	–	0.57%	–
VRNA	New	VERONA PHARMA PLCsponsored ads	$21,369,000	–	5,100,000	–	0.57%	–
RYTM	New	RHYTHM PHARMACEUTICALS INC	$20,215,000	–	4,871,067	–	0.54%	–
	New	TENAYA THERAPEUTICS INC	$19,995,000	–	3,551,508	–	0.53%	–
DYN	New	DYNE THERAPEUTICS INC	$19,271,000	–	2,805,045	–	0.51%	–
	New	HILLEVAX INC	$19,237,000	–	1,760,019	–	0.51%	–
GH	New	GUARDANT HEALTH INC	$19,217,000	–	476,380	–	0.51%	–
	New	PARDES BIOSCIENCES INC	$18,957,000	–	6,175,038	–	0.50%	–
HOWL	New	WEREWOLF THERAPEUTICS INC	$17,554,000	–	4,291,881	–	0.47%	–
	New	DA32 LIFE SCNCE	$14,535,000	–	1,500,000	–	0.39%	–
CNCE	New	CONCERT PHARMACEUTICALS INC	$13,923,000	–	3,307,203	–	0.37%	–
MIST	New	MILESTONE PHARMACEUTICALS IN	$13,816,000	–	2,246,503	–	0.37%	–
ACHL	New	ACHILLES THERAPEUTICS PLCsponsored ads	$12,637,000	–	5,014,687	–	0.34%	–
BLSA	New	BCLS ACQUISITION CORP	$12,375,000	–	1,250,000	–	0.33%	–
OTIC	New	OTONOMY INC	$11,648,000	–	5,600,000	–	0.31%	–
	New	LIANBIOsponsored ads	$9,985,000	–	4,622,574	–	0.27%	–
FLACU	New	FRAZIER LIFESCIENCES ACQU CO	$9,870,000	–	1,000,000	–	0.26%	–
	New	ARYA SCIENCES ACQUISITN	$9,720,000	–	1,000,000	–	0.26%	–
RLAY	New	RELAY THERAPEUTICS INC	$9,197,000	–	549,055	–	0.24%	–
	New	IO BIOTECH INC	$8,676,000	–	1,857,755	–	0.23%	–
SLDB	New	SOLID BIOSCIENCES INC	$7,614,000	–	12,367,873	–	0.20%	–
FVAM	New	5 01 ACQUISITION CORP	$7,425,000	–	750,000	–	0.20%	–
SYBX	New	SYNLOGIC INC	$6,700,000	–	5,825,858	–	0.18%	–
BDTX	New	BLACK DIAMOND THERAPEUTICS I	$6,371,000	–	2,589,904	–	0.17%	–
IPSC	New	CENTURY THERAPEUTICS INC	$6,357,000	–	756,821	–	0.17%	–
HSAQ	New	HEALTH SCIENCES ACQ CORP 2	$6,225,000	–	625,000	–	0.17%	–
CNTB	New	CONNECT BIOPHARMA HLDGS LTDads	$6,082,000	–	6,991,003	–	0.16%	–
BMEA	New	BIOMEA FUSION INC	$5,990,000	–	500,000	–	0.16%	–
ATHA	New	ATHIRA PHARMA INC	$5,728,000	–	1,878,000	–	0.15%	–
	New	XILIO THERAPEUTICS INC	$4,817,000	–	1,649,711	–	0.13%	–
	New	AADI BIOSCIENCE INC	$4,719,000	–	383,028	–	0.13%	–
FLDM	New	STANDARD BIOTOOLS INC	$3,180,000	–	1,987,589	–	0.08%	–
ENTX	New	ENTERA BIO LTD	$3,129,000	–	2,353,000	–	0.08%	–
TERN	New	TERNS PHARMACEUTICALS INC	$3,128,000	–	1,261,435	–	0.08%	–
BCAB	New	BIOATLA INC	$2,941,000	–	1,031,805	–	0.08%	–
	New	ASTRIA THERAPEUTICS INC	$2,283,000	–	760,857	–	0.06%	–
	New	PYXIS ONCOLOGY INC	$2,269,000	–	953,393	–	0.06%	–
ADVM	New	ADVERUM BIOTECHNOLOGIES INC	$2,071,000	–	1,726,019	–	0.06%	–
LRMR	New	LARIMAR THERAPEUTICS INC	$2,022,000	–	1,031,482	–	0.05%	–
ORTX	New	ORCHARD THERAPEUTICS PLCads	$1,776,000	–	3,040,885	–	0.05%	–
CVRX	New	CVRX INC	$1,653,000	–	275,000	–	0.04%	–
SNSE	New	SENSEI BIOTHERAPEUTICS	$1,642,000	–	723,549	–	0.04%	–
OLMA	New	OLEMA PHARMACEUTICALS INC	$952,000	–	233,793	–	0.02%	–
BOLT	New	BOLT BIOTHERAPEUTICS INC	$918,000	–	450,141	–	0.02%	–
AVRO	New	AVROBIO INC	$515,000	–	559,600	–	0.01%	–
CLBS	New	CALADRIUS BIOSCIENCES	$399,000	–	752,500	–	0.01%	–

Q4 2021

			Value		Shares		↓ Weighting
VRDN	Exit	VIRIDIAN THERAPEUTICS INC	$0	–	-1,034	–	0.00%	–
RPHM	Exit	RENEO PHARMACEUTICALS INC	$0	–	-62,217	–	-0.01%	–
OTIC	Exit	OTONOMY INC	$0	–	-1,631,635	–	-0.04%	–
CCXI	Exit	CHEMOCENTRYX INC	$0	–	-218,532	–	-0.05%	–
SYRS	Exit	SYROS PHARMACEUTICALS INC	$0	–	-900,000	–	-0.06%	–
CVRX	Exit	CVRX INC	$0	–	-275,000	–	-0.06%	–
BMEA	Exit	BIOMEA FUSION INC	$0	–	-500,000	–	-0.08%	–
HSAQ	Exit	HEALTH SCIENCES ACQ CORP 2	$0	–	-625,000	–	-0.09%	–
HLXA	Exit	HELIX ACQUISITION CORP	$0	–	-700,000	–	-0.10%	–
FVAM	Exit	5 01 ACQUISITION CORP	$0	–	-750,000	–	-0.10%	–
OCUL	Exit	OCULAR THERAPEUTIX INC	$0	–	-750,000	–	-0.10%	–
CGEM	Exit	CULLINAN ONCOLOGY INC	$0	–	-350,000	–	-0.11%	–
COGT	Exit	COGENT BIOSCIENCES INC	$0	–	-1,025,641	–	-0.12%	–
	Exit	CUE HEALTH INC	$0	–	-750,000	–	-0.12%	–
PHAS	Exit	PHASEBIO PHARMACEUTICALS INC	$0	–	-2,850,000	–	-0.12%	–
IKNA	Exit	IKENA ONCOLOGY INC	$0	–	-750,000	–	-0.13%	–
FLACU	Exit	FRAZIER LIFESCIENCES ACQUISITION CO	$0	–	-1,000,000	–	-0.14%	–
CNCE	Exit	CONCERT PHARMACEUTICALS INC	$0	–	-3,033,603	–	-0.14%	–
	Exit	ARYA SCIENCES ACQUISITN CORP	$0	–	-1,000,000	–	-0.14%	–
FSII	Exit	FS DEVELOPMENT CORP II	$0	–	-1,000,000	–	-0.14%	–
	Exit	AADI BIOSCIENCES INC	$0	–	-347,668	–	-0.14%	–
	Exit	TSCAN THERAPEUTICS INC	$0	–	-1,255,317	–	-0.14%	–
RNA	Exit	AVIDITY BIOSCIENCES INC	$0	–	-423,616	–	-0.14%	–
ENTX	Exit	ENTERA BIO LTD	$0	–	-2,353,000	–	-0.15%	–
	Exit	ASTRIA THERAPEUTICS INC	$0	–	-1,262,193	–	-0.16%	–
BLSA	Exit	BCLS ACQUISITION CORP	$0	–	-1,250,000	–	-0.17%	–
MIST	Exit	MILESTONE PHARMACEUTICALS INC	$0	–	-2,246,503	–	-0.18%	–
	Exit	DA32 LIFE SCNCE	$0	–	-1,500,000	–	-0.20%	–
NAUT	Exit	NAUTILUS BIOTECHNOLOGY INC	$0	–	-2,436,430	–	-0.21%	–
SBTX	Exit	SILVERBACK THERAPEUTICS INC	$0	–	-1,742,186	–	-0.24%	–
LRMR	Exit	LARIMAR THERAPEUTICS INC	$0	–	-1,515,151	–	-0.24%	–
CTMX	Exit	CYTOMX THERAPEUTICS INC	$0	–	-3,500,000	–	-0.25%	–
SCPH	Exit	SCPHARMACEUTICALS INC	$0	–	-2,731,170	–	-0.25%	–
SYBX	Exit	SYNLOGIC INC	$0	–	-6,666,666	–	-0.28%	–
BDTX	Exit	BLACK DIAMOND THERAPEUTICS INC	$0	–	-2,589,904	–	-0.30%	–
IPSC	Exit	CENTURY THERAPEUTICS INC	$0	–	-914,094	–	-0.32%	–
EYPT	Exit	EYEPOINT PHARMACEUTICALS INC	$0	–	-2,210,506	–	-0.32%	–
ORTX	Exit	ORCHARD THERAPEUTICS PLCads	$0	–	-11,028,722	–	-0.35%	–
AKUS	Exit	AKOUOS INC	$0	–	-2,281,249	–	-0.37%	–
STSA	Exit	SATSUMA PHARMACEUTICALS INC	$0	–	-5,914,252	–	-0.38%	–
VRNA	Exit	VERONA PHARMA PLCsponsored ads	$0	–	-5,100,000	–	-0.39%	–
KALA	Exit	KALA PHARMACEUTICALS INC	$0	–	-10,874,613	–	-0.40%	–
	Exit	TANGO THERAPEUTICS INC	$0	–	-2,250,000	–	-0.40%	–
SLDB	Exit	SOLID BIOSCIENCES INC	$0	–	-12,367,873	–	-0.41%	–
BOLT	Exit	BOLT BIOTHERAPEUTICS INC	$0	–	-2,378,325	–	-0.42%	–
DSGN	Exit	DESIGN THERAPEUTICS INC	$0	–	-2,186,636	–	-0.44%	–
KALV	Exit	KALVISTA PHARMACEUTICALS INC	$0	–	-1,930,322	–	-0.47%	–
WVE	Exit	WAVE LIFE SCIENCES LTD	$0	–	-7,775,207	–	-0.53%	–
	Exit	RXSIGHT INC	$0	–	-3,052,796	–	-0.54%	–
ACHL	Exit	ACHILLES THERAPEUTICS PLCsponsored ads	$0	–	-5,014,687	–	-0.54%	–
GERN	Exit	GERON CORP	$0	–	-30,126,299	–	-0.57%	–
VERV	Exit	VERVE THERAPEUTICS INC	$0	–	-880,284	–	-0.57%	–
EWTX	Exit	EDGEWISE THERAPEUTICS INC	$0	–	-2,613,623	–	-0.60%	–
GRPH	Exit	GRAPHITE BIO INC	$0	–	-2,698,369	–	-0.61%	–
DYN	Exit	DYNE THERAPEUTICS INC	$0	–	-2,805,045	–	-0.63%	–
ZGNX	Exit	ZOGENIX INC	$0	–	-3,333,700	–	-0.70%	–
PMVP	Exit	PMV PHARMACEUTICALS INC	$0	–	-1,710,265	–	-0.71%	–
CYT	Exit	CYTEIR THERAPEUTICS INC	$0	–	-3,350,506	–	-0.82%	–
OLMA	Exit	OLEMA PHARMACEUTICALS INC	$0	–	-2,150,404	–	-0.82%	–
CNTA	Exit	CENTESSA PHARMACEUTICALS PLCsponsored ads	$0	–	-3,577,094	–	-0.83%	–
CCCC	Exit	C4 THERAPEUTICS INC	$0	–	-1,377,569	–	-0.85%	–
RCKT	Exit	ROCKET PHARMACEUTICALS INC COM	$0	–	-2,107,149	–	-0.87%	–
RYTM	Exit	RHYTHM PHARMACEUTICALS INC	$0	–	-4,871,067	–	-0.88%	–
GHRS	Exit	GH RESEARCH PLCordinary shares	$0	–	-3,013,957	–	-0.92%	–
PNT	Exit	POINT BIOPHARMA GLOBAL	$0	–	-8,856,018	–	-0.94%	–
	Exit	TENAYA THERAPEUTICS INC	$0	–	-3,551,508	–	-1.02%	–
HOWL	Exit	WEREWOLF THERAPEUTICS INC	$0	–	-4,291,881	–	-1.02%	–
KNTE	Exit	KINNATE BIOPHARMA INC	$0	–	-3,593,052	–	-1.15%	–
CLDX	Exit	CELLDEX THERAPEUTICS INC NEW	$0	–	-1,600,000	–	-1.20%	–
TIL	Exit	INSTIL BIO INC	$0	–	-4,870,793	–	-1.21%	–
ETNB	Exit	89BIO INC	$0	–	-4,965,769	–	-1.35%	–
PCVX	Exit	VAXCYTE INC	$0	–	-3,896,865	–	-1.37%	–
PHAT	Exit	PHATHOM PHARMACEUTICALS INC	$0	–	-3,115,008	–	-1.39%	–
IMGN	Exit	IMMUNOGEN INC	$0	–	-18,417,458	–	-1.45%	–
DAWN	Exit	DAY ONE BIOPHARMACEUTICALS I	$0	–	-4,965,588	–	-1.63%	–
ITOS	Exit	ITEOS THERAPEUTICS INC	$0	–	-4,417,259	–	-1.65%	–
MGNX	Exit	MACROGENICS INC	$0	–	-5,943,594	–	-1.72%	–
	Exit	TYRA BIOSCIENCES INC	$0	–	-7,236,454	–	-1.76%	–
TVTX	Exit	TRAVERE THERAPEUTICS INC	$0	–	-5,614,428	–	-1.89%	–
TGTX	Exit	TG THERAPEUTICS INC	$0	–	-4,098,332	–	-1.89%	–
ABOS	Exit	ACUMEN PHARMACEUTICALS INC	$0	–	-9,770,773	–	-2.01%	–
NKTX	Exit	NKARTA INC	$0	–	-5,605,129	–	-2.16%	–
CNTB	Exit	CONNECT BIOPHARMA HLDGS LTDads	$0	–	-6,991,003	–	-2.35%	–
	Exit	DICE THERAPEUTICS INC	$0	–	-5,208,911	–	-2.36%	–
	Exit	ICOSAVAX INC	$0	–	-5,779,347	–	-2.37%	–
AVTE	Exit	AEROVATE THERAPEUTICS INC	$0	–	-8,263,982	–	-2.40%	–
VOR	Exit	VOR BIOPHARMA INC	$0	–	-11,120,973	–	-2.42%	–
JANX	Exit	JANUX THERAPEUTICS INC	$0	–	-8,670,644	–	-2.60%	–
AVIR	Exit	ATEA PHARMACEUTICALS INC	$0	–	-5,427,655	–	-2.64%	–
	Exit	CYTEK BIOSCIENCES INC	$0	–	-9,607,028	–	-2.85%	–
FMTX	Exit	FORMA THERAPEUTICS HLDGS INC	$0	–	-9,011,651	–	-2.90%	–
	Exit	ADAGIO THERAPEUTICS INC	$0	–	-5,340,130	–	-3.13%	–
	Exit	ELIEM THERAPEUTICS INC	$0	–	-13,150,849	–	-3.28%	–
NVAX	Exit	NOVAVAX INC	$0	–	-2,097,794	–	-6.03%	–
ASND	Exit	ASCENDIS PHARMA A/Ssponsored adr	$0	–	-7,387,900	–	-16.32%	–

Q3 2021

			Value		Shares		↓ Weighting
ASND	Buy	ASCENDIS PHARMA A/Ssponsored adr	$1,177,557,000	+31.5%	7,387,900	+8.5%	16.32%	+13.5%
NVAX	Sell	NOVAVAX INC	$434,894,000	-20.0%	2,097,794	-18.1%	6.03%	-30.9%
	New	ELIEM THERAPEUTICS INC	$236,452,000	–	13,150,849	–	3.28%	–
	New	ADAGIO THERAPEUTICS INC	$225,567,000	–	5,340,130	–	3.13%	–
	New	CYTEK BIOSCIENCES INC	$205,686,000	–	9,607,028	–	2.85%	–
AVIR	Buy	ATEA PHARMACEUTICALS INC	$190,294,000	+65.0%	5,427,655	+1.1%	2.64%	+42.5%
	New	ICOSAVAX INC	$171,011,000	–	5,779,347	–	2.37%	–
	New	DICE THERAPEUTICS INC	$170,592,000	–	5,208,911	–	2.36%	–
ABOS	New	ACUMEN PHARMACEUTICALS INC	$145,194,000	–	9,770,773	–	2.01%	–
TGTX	Buy	TG THERAPEUTICS INC	$136,392,000	+5.2%	4,098,332	+22.6%	1.89%	-9.2%
	New	TYRA BIOSCIENCES INC	$127,289,000	–	7,236,454	–	1.76%	–
PCVX	Buy	VAXCYTE INC	$98,863,000	+13.6%	3,896,865	+0.8%	1.37%	-1.9%
CLDX	New	CELLDEX THERAPEUTICS INC NEW	$86,384,000	–	1,600,000	–	1.20%	–
	New	TENAYA THERAPEUTICS INC	$73,339,000	–	3,551,508	–	1.02%	–
PNT	New	POINT BIOPHARMA GLOBAL	$68,103,000	–	8,856,018	–	0.94%	–
GHRS	Buy	GH RESEARCH PLCordinary shares	$66,488,000	+2.7%	3,013,957	+1.2%	0.92%	-11.4%
CNTA	Buy	CENTESSA PHARMACEUTICALS PLCsponsored ads	$59,737,000	+110.1%	3,577,094	+179.4%	0.83%	+81.6%
CYT	Buy	CYTEIR THERAPEUTICS INC	$58,801,000	-15.4%	3,350,506	+3.2%	0.82%	-26.9%
ZGNX	Sell	ZOGENIX INC	$50,639,000	-44.5%	3,333,700	-36.9%	0.70%	-52.1%
	New	RXSIGHT INC	$38,679,000	–	3,052,796	–	0.54%	–
	New	TANGO THERAPEUTICS INC	$29,093,000	–	2,250,000	–	0.40%	–
ORTX	Sell	ORCHARD THERAPEUTICS PLCads	$25,366,000	-53.1%	11,028,722	-10.4%	0.35%	-59.6%
EYPT	Buy	EYEPOINT PHARMACEUTICALS INC	$23,033,000	+105.0%	2,210,506	+76.8%	0.32%	+77.2%
SYBX	New	SYNLOGIC INC	$20,333,000	–	6,666,666	–	0.28%	–
NAUT	Sell	NAUTILUS BIOTECHNOLOGY INC	$14,960,000	-40.1%	2,436,430	-1.4%	0.21%	-48.4%
	New	DA32 LIFE SCNCE	$14,745,000	–	1,500,000	–	0.20%	–
	New	ASTRIA THERAPEUTICS INC	$11,158,000	–	1,262,193	–	0.16%	–
RNA	New	AVIDITY BIOSCIENCES INC	$10,434,000	–	423,616	–	0.14%	–
	New	TSCAN THERAPEUTICS INC	$10,469,000	–	1,255,317	–	0.14%	–
	New	AADI BIOSCIENCES INC	$10,211,000	–	347,668	–	0.14%	–
	New	ARYA SCIENCES ACQUISITN CORP	$9,880,000	–	1,000,000	–	0.14%	–
	New	CUE HEALTH INC	$8,858,000	–	750,000	–	0.12%	–
CCXI	Sell	CHEMOCENTRYX INC	$3,737,000	-92.0%	218,532	-93.8%	0.05%	-93.1%
OTIC	New	OTONOMY INC	$3,133,000	–	1,631,635	–	0.04%	–
VRDN	Sell	VIRIDIAN THERAPEUTICS INC	$17,000	-99.7%	1,034	-99.7%	0.00%	-100.0%
MCRB	Exit	SERES THERAPEUTICS INC	$0	–	-5,105,547	–	-0.03%	–
IMRA	Exit	IMARA INC	$0	–	-248,804	–	-0.03%	–
NTLA	Exit	INTELLIA THERAPEUTICS INC	$0	–	-15,000	–	-0.04%	–
CEREW	Exit	CEREVEL THERAPEUTICS HLDNG INC*w exp 06/09/2027	$0	–	-233,333	–	-0.05%	–
ARPO	Exit	AERPIO PHARMACEUTICALS INC	$0	–	-2,693,309	–	-0.07%	–
TXMD	Exit	THERAPEUTICSMD INC	$0	–	-7,812,500	–	-0.15%	–
ORIC	Exit	ORIC PHARMACEUTICALS INC	$0	–	-584,000	–	-0.17%	–
ARYD	Exit	ARYA SCIENCES ACQU CORP IVcl a	$0	–	-1,000,000	–	-0.17%	–
RACA	Exit	THERAPEUTICS ACQUISITION COR	$0	–	-1,098,318	–	-0.18%	–
	Exit	CATABASIS PHARMACEUTICALS IN	$0	–	-5,947,861	–	-0.20%	–
BCTG	Exit	BCTG ACQUISITION CORP	$0	–	-1,250,000	–	-0.23%	–
INZY	Exit	INOZYME PHARMA INC	$0	–	-2,003,653	–	-0.55%	–
LEGN	Exit	LEGEND BIOTECH CORPsponsored ads	$0	–	-977,503	–	-0.64%	–
ARDX	Exit	ARDELYX INC	$0	–	-6,077,294	–	-0.74%	–
	Exit	TRILLIUM THERAPEUTICS INC	$0	–	-5,290,481	–	-0.82%	–
CERE	Exit	CEREVEL THERAPEUTICS HLDNG INC	$0	–	-2,200,000	–	-0.90%	–
CRIS	Exit	CURIS INC	$0	–	-7,140,091	–	-0.92%	–
AXSM	Exit	AXSOME THERAPEUTICS INC	$0	–	-1,655,447	–	-1.79%	–

Q2 2021

			Value		Shares		↓ Weighting
ASND	New	ASCENDIS PHARMA A/Ssponsored adr	$895,374,000	–	6,806,341	–	14.37%	–
NVAX	New	NOVAVAX INC	$543,496,000	–	2,559,918	–	8.72%	–
FMTX	New	FORMA THERAPEUTICS HLDGS INC	$224,300,000	–	9,011,651	–	3.60%	–
JANX	New	JANUX THERAPEUTICS INC	$216,333,000	–	8,670,644	–	3.47%	–
VOR	New	VOR BIOPHARMA INC	$207,406,000	–	11,120,973	–	3.33%	–
AVTE	New	AEROVATE THERAPEUTICS INC	$188,667,000	–	8,263,982	–	3.03%	–
NKTX	New	NKARTA INC	$177,627,000	–	5,605,129	–	2.85%	–
MGNX	New	MACROGENICS INC	$159,645,000	–	5,943,594	–	2.56%	–
CNTB	New	CONNECT BIOPHARMA HLDGS LTDads	$136,534,000	–	6,991,003	–	2.19%	–
TGTX	New	TG THERAPEUTICS INC	$129,665,000	–	3,342,743	–	2.08%	–
IMGN	New	IMMUNOGEN INC	$121,371,000	–	18,417,458	–	1.95%	–
AVIR	New	ATEA PHARMACEUTICALS INC	$115,314,000	–	5,368,451	–	1.85%	–
ITOS	New	ITEOS THERAPEUTICS INC	$113,303,000	–	4,417,259	–	1.82%	–
DAWN	New	DAY ONE BIOPHARMACEUTICALS I	$113,066,000	–	4,965,588	–	1.82%	–
AXSM	New	AXSOME THERAPEUTICS INC	$111,676,000	–	1,655,447	–	1.79%	–
PHAT	New	PHATHOM PHARMACEUTICALS INC	$105,443,000	–	3,115,008	–	1.69%	–
TIL	New	INSTIL BIO INC	$94,104,000	–	4,870,793	–	1.51%	–
RCKT	New	ROCKET PHARMACEUTICALS INC COM	$93,326,000	–	2,107,149	–	1.50%	–
ETNB	New	89BIO INC	$92,860,000	–	4,965,769	–	1.49%	–
ZGNX	New	ZOGENIX INC	$91,307,000	–	5,283,976	–	1.46%	–
PCVX	New	VAXCYTE INC	$87,019,000	–	3,865,808	–	1.40%	–
KNTE	New	KINNATE BIOPHARMA INC	$83,646,000	–	3,593,052	–	1.34%	–
GRPH	New	GRAPHITE BIO INC	$82,921,000	–	2,698,369	–	1.33%	–
TVTX	New	TRAVERE THERAPEUTICS INC	$81,915,000	–	5,614,428	–	1.32%	–
HOWL	New	WEREWOLF THERAPEUTICS INC	$74,850,000	–	4,291,881	–	1.20%	–
RYTM	New	RHYTHM PHARMACEUTICALS INC	$71,077,000	–	4,871,067	–	1.14%	–
CYT	New	CYTEIR THERAPEUTICS INC	$69,488,000	–	3,247,117	–	1.12%	–
GHRS	New	GH RESEARCH PLCordinary shares	$64,733,000	–	2,978,955	–	1.04%	–
OLMA	New	OLEMA PHARMACEUTICALS INC	$60,168,000	–	2,150,404	–	0.97%	–
DYN	New	DYNE THERAPEUTICS INC	$59,018,000	–	2,805,045	–	0.95%	–
PMVP	New	PMV PHARMACEUTICALS INC	$58,423,000	–	1,710,265	–	0.94%	–
CRIS	New	CURIS INC	$57,621,000	–	7,140,091	–	0.92%	–
KALA	New	KALA PHARMACEUTICALS INC	$57,635,000	–	10,874,613	–	0.92%	–
CERE	New	CEREVEL THERAPEUTICS HLDNG INC	$56,364,000	–	2,200,000	–	0.90%	–
EWTX	New	EDGEWISE THERAPEUTICS INC	$55,749,000	–	2,613,623	–	0.90%	–
ORTX	New	ORCHARD THERAPEUTICS PLCads	$54,064,000	–	12,315,213	–	0.87%	–
SBTX	New	SILVERBACK THERAPEUTICS INC	$53,816,000	–	1,742,186	–	0.86%	–
VERV	New	VERVE THERAPEUTICS INC	$53,037,000	–	880,284	–	0.85%	–
CCCC	New	C4 THERAPEUTICS INC	$52,127,000	–	1,377,569	–	0.84%	–
WVE	New	WAVE LIFE SCIENCES LTD	$51,783,000	–	7,775,207	–	0.83%	–
	New	TRILLIUM THERAPEUTICS INC	$51,318,000	–	5,290,481	–	0.82%	–
ACHL	New	ACHILLES THERAPEUTICS PLCsponsored ads	$49,094,000	–	5,014,687	–	0.79%	–
CCXI	New	CHEMOCENTRYX INC	$46,820,000	–	3,496,639	–	0.75%	–
KALV	New	KALVISTA PHARMACEUTICALS INC	$46,251,000	–	1,930,322	–	0.74%	–
ARDX	New	ARDELYX INC	$46,066,000	–	6,077,294	–	0.74%	–
SLDB	New	SOLID BIOSCIENCES INC	$45,266,000	–	12,367,873	–	0.73%	–
DSGN	New	DESIGN THERAPEUTICS INC	$43,492,000	–	2,186,636	–	0.70%	–
GERN	New	GERON CORP	$42,478,000	–	30,126,299	–	0.68%	–
STSA	New	SATSUMA PHARMACEUTICALS INC	$41,695,000	–	5,914,252	–	0.67%	–
LEGN	New	LEGEND BIOTECH CORPsponsored ads	$40,126,000	–	977,503	–	0.64%	–
BOLT	New	BOLT BIOTHERAPEUTICS INC	$36,769,000	–	2,378,325	–	0.59%	–
INZY	New	INOZYME PHARMA INC	$34,142,000	–	2,003,653	–	0.55%	–
VRNA	New	VERONA PHARMA PLCsponsored ads	$33,354,000	–	5,100,000	–	0.54%	–
BDTX	New	BLACK DIAMOND THERAPEUTICS INC	$31,571,000	–	2,589,904	–	0.51%	–
AKUS	New	AKOUOS INC	$28,630,000	–	2,281,249	–	0.46%	–
CNTA	New	CENTESSA PHARMACEUTICALS PLCsponsored ads	$28,435,000	–	1,280,300	–	0.46%	–
IPSC	New	CENTURY THERAPEUTICS INC	$26,820,000	–	914,094	–	0.43%	–
NAUT	New	NAUTILUS BIOTECHNOLOGY INC	$24,961,000	–	2,471,430	–	0.40%	–
CTMX	New	CYTOMX THERAPEUTICS INC	$22,155,000	–	3,500,000	–	0.36%	–
SCPH	New	SCPHARMACEUTICALS INC	$16,687,000	–	2,731,170	–	0.27%	–
LRMR	New	LARIMAR THERAPEUTICS INC	$14,879,000	–	1,515,151	–	0.24%	–
BCTG	New	BCTG ACQUISITION CORP	$14,225,000	–	1,250,000	–	0.23%	–
ENTX	New	ENTERA BIO LTD	$14,071,000	–	2,353,000	–	0.23%	–
BLSA	New	BCLS ACQUISITION CORP	$13,163,000	–	1,250,000	–	0.21%	–
CNCE	New	CONCERT PHARMACEUTICALS INC	$12,802,000	–	3,033,603	–	0.20%	–
	New	CATABASIS PHARMACEUTICALS IN	$12,550,000	–	5,947,861	–	0.20%	–
MIST	New	MILESTONE PHARMACEUTICALS INC	$12,356,000	–	2,246,503	–	0.20%	–
RACA	New	THERAPEUTICS ACQUISITION COR	$11,284,000	–	1,098,318	–	0.18%	–
EYPT	New	EYEPOINT PHARMACEUTICALS INC	$11,238,000	–	1,250,000	–	0.18%	–
ARYD	New	ARYA SCIENCES ACQU CORP IVcl a	$10,720,000	–	1,000,000	–	0.17%	–
OCUL	New	OCULAR THERAPEUTIX INC	$10,635,000	–	750,000	–	0.17%	–
PHAS	New	PHASEBIO PHARMACEUTICALS INC	$10,602,000	–	2,850,000	–	0.17%	–
IKNA	New	IKENA ONCOLOGY INC	$10,530,000	–	750,000	–	0.17%	–
ORIC	New	ORIC PHARMACEUTICALS INC	$10,331,000	–	584,000	–	0.17%	–
FLACU	New	FRAZIER LIFESCIENCES ACQUISITION COunit 12/09/2025	$10,050,000	–	1,000,000	–	0.16%	–
FSII	New	FS DEVELOPMENT CORP II	$9,980,000	–	1,000,000	–	0.16%	–
TXMD	New	THERAPEUTICSMD INC	$9,297,000	–	7,812,500	–	0.15%	–
CGEM	New	CULLINAN ONCOLOGY INC	$9,013,000	–	350,000	–	0.14%	–
COGT	New	COGENT BIOSCIENCES INC	$8,318,000	–	1,025,641	–	0.13%	–
BMEA	New	BIOMEA FUSION INC	$7,805,000	–	500,000	–	0.12%	–
CVRX	New	CVRX INC	$7,700,000	–	275,000	–	0.12%	–
FVAM	New	5 01 ACQUISITION CORP	$7,478,000	–	750,000	–	0.12%	–
HLXA	New	HELIX ACQUISITION CORP	$7,245,000	–	700,000	–	0.12%	–
HSAQ	New	HEALTH SCIENCES ACQ CORP 2	$6,375,000	–	625,000	–	0.10%	–
VRDN	New	VIRIDIAN THERAPEUTICS INC	$5,712,000	–	312,328	–	0.09%	–
SYRS	New	SYROS PHARMACEUTICALS INC	$4,905,000	–	900,000	–	0.08%	–
ARPO	New	AERPIO PHARMACEUTICALS INC	$4,552,000	–	2,693,309	–	0.07%	–
CEREW	New	CEREVEL THERAPEUTICS HLDNG INC*w exp 06/09/2027	$3,358,000	–	233,333	–	0.05%	–
NTLA	New	INTELLIA THERAPEUTICS INC	$2,429,000	–	15,000	–	0.04%	–
IMRA	New	IMARA INC	$1,966,000	–	248,804	–	0.03%	–
MCRB	New	SERES THERAPEUTICS INC	$1,900,000	–	5,105,547	–	0.03%	–
RPHM	New	RENEO PHARMACEUTICALS INC	$580,000	–	62,217	–	0.01%	–

Q4 2020

			Value		Shares		↓ Weighting
OVID	Exit	OVID THERAPEUTICS INC	$0	–	-285,000	–	-0.03%	–
EPIX	Exit	ESSA PHARMA INC	$0	–	-470,428	–	-0.06%	–
XFOR	Exit	X4 PHARMACEUTICALS INC	$0	–	-559,494	–	-0.07%	–
PASG	Exit	PASSAGE BIO INC	$0	–	-322,630	–	-0.08%	–
IMRA	Exit	IMARA INC	$0	–	-249,739	–	-0.09%	–
CLDX	Exit	CELLDEX THERAPEUTICS INC NEW	$0	–	-353,072	–	-0.10%	–
HSAQ	Exit	HEALTH SCIENCES ACQ CORP 2	$0	–	-625,000	–	-0.13%	–
GRTX	Exit	GALERA THERAPEUTICS INC	$0	–	-825,118	–	-0.14%	–
ARYBU	Exit	ARYA SCIENCES ACQUISITION CORPunit 06/09/2027	$0	–	-700,000	–	-0.14%	–
LYRA	Exit	LYRA THERAPEUTICS INC	$0	–	-815,849	–	-0.17%	–
SLDB	Exit	SOLID BIOSCIENCES INC	$0	–	-4,571,164	–	-0.17%	–
VSTM	Exit	VERASTEM INC	$0	–	-8,066,171	–	-0.18%	–
ARYA	Exit	ARYA SCIENCES ACQUISITION CO	$0	–	-1,000,000	–	-0.20%	–
FSDC	Exit	FS DEV CORP	$0	–	-1,000,000	–	-0.20%	–
RPTX	Exit	REPARE THERAPEUTICS INC	$0	–	-409,000	–	-0.23%	–
BCTG	Exit	BCTG ACQUISITION CORP	$0	–	-1,250,000	–	-0.24%	–
SNDX	Exit	SYNDAX PHARMACEUTICALS INC	$0	–	-1,023,067	–	-0.28%	–
MIST	Exit	MILESTONE PHARMACEUTICALS INC	$0	–	-2,418,798	–	-0.32%	–
STSA	Exit	SATSUMA PHARMACEUTICALS INC	$0	–	-4,681,858	–	-0.33%	–
CNCE	Exit	CONCERT PHARMACEUTICALS INC	$0	–	-1,858,474	–	-0.33%	–
PRVL	Exit	PREVAIL THERAPEUTICS INC	$0	–	-1,915,568	–	-0.36%	–
PAND	Exit	PANDION THERAPEUTICS INC	$0	–	-1,770,023	–	-0.37%	–
OCUL	Exit	OCULAR THERAPEUTIX INC	$0	–	-2,727,272	–	-0.38%	–
STRO	Exit	SUTRO BIOPHARMA INC	$0	–	-2,118,212	–	-0.39%	–
LRMR	Exit	LARIMAR THERAPEUTICS INC	$0	–	-1,515,151	–	-0.42%	–
IMGN	Exit	IMMUNOGEN INC	$0	–	-7,040,485	–	-0.46%	–
SCPH	Exit	SCPHARMACEUTICALS INC	$0	–	-3,518,998	–	-0.48%	–
RLMD	Exit	RELMADA THERAPEUTICS INC	$0	–	-781,290	–	-0.54%	–
VRNA	Exit	VERONA PHARMA PLCsponsored ads	$0	–	-5,100,000	–	-0.58%	–
ARDX	Exit	ARDELYX INC	$0	–	-6,260,904	–	-0.60%	–
ARQT	Exit	ARCUTIS BIOTHERAPEUTICS INC	$0	–	-1,165,184	–	-0.62%	–
CRNX	Exit	CRINETICS PHARMACEUTICALS INC	$0	–	-2,328,698	–	-0.67%	–
ALEC	Exit	ALECTOR INC	$0	–	-3,618,748	–	-0.70%	–
INBX	Exit	INHIBRX INC	$0	–	-2,129,003	–	-0.70%	–
RLAY	Exit	RELAY THERAPEUTICS INC	$0	–	-1,000,000	–	-0.78%	–
CRDF	Exit	CARDIFF ONCOLOGY INC	$0	–	-3,290,000	–	-0.85%	–
ORTX	Exit	ORCHARD THERAPEUTICS PLCads	$0	–	-12,315,213	–	-0.93%	–
AKUS	Exit	AKOUOS INC	$0	–	-2,281,249	–	-0.95%	–
GERN	Exit	GERON CORP	$0	–	-30,126,299	–	-0.96%	–
INZY	Exit	INOZYME PHARMA INC	$0	–	-2,003,653	–	-0.96%	–
DYN	Exit	DYNE THERAPEUTICS INC	$0	–	-2,805,045	–	-1.04%	–
PMVP	Exit	PMV PHARMACEUTICALS INC	$0	–	-1,710,265	–	-1.11%	–
WVE	Exit	WAVE LIFE SCIENCES LTD	$0	–	-7,775,207	–	-1.21%	–
VXRT	Exit	VAXART INC	$0	–	-10,810,937	–	-1.32%	–
KROS	Exit	KEROS THERAPEUTICS INC	$0	–	-1,875,000	–	-1.32%	–
IGMS	Exit	IGM BIOSCIENCES INC	$0	–	-982,723	–	-1.33%	–
LEGN	Exit	LEGEND BIOTECH CORPsponsored ads	$0	–	-2,408,292	–	-1.36%	–
BDTX	Exit	BLACK DIAMOND THERAPEUTICS INC	$0	–	-2,589,904	–	-1.43%	–
KALA	Exit	KALA PHARMACEUTICALS INC	$0	–	-10,874,613	–	-1.49%	–
RTRX	Exit	RETROPHIN INC	$0	–	-4,635,687	–	-1.56%	–
ARVN	Exit	ARVINAS INC	$0	–	-3,672,872	–	-1.59%	–
	Exit	TRILLIUM THERAPEUTICS INC	$0	–	-6,162,694	–	-1.60%	–
ADAP	Exit	ADAPTIMMUNE THERAPEUTICS PLCsponds adr	$0	–	-11,329,581	–	-1.65%	–
ADVM	Exit	ADVERUM BIOTECHNOLOGIES INC	$0	–	-9,410,860	–	-1.77%	–
ZGNX	Exit	ZOGENIX INC	$0	–	-5,488,424	–	-1.80%	–
ITOS	Exit	ITEOS THERAPEUTICS INC	$0	–	-4,417,258	–	-1.99%	–
EIDX	Exit	EIDOS THERAPEUTICS INC	$0	–	-2,163,271	–	-2.00%	–
MGNX	Exit	MACROGENICS INC	$0	–	-4,375,217	–	-2.02%	–
RYTM	Exit	RHYTHM PHARMACEUTICALS INC	$0	–	-5,140,408	–	-2.04%	–
ETNB	Exit	89BIO INC	$0	–	-4,736,214	–	-2.22%	–
NVAX	Exit	NOVAVAX INC	$0	–	-1,198,602	–	-2.38%	–
MCRB	Exit	SERES THERAPEUTICS INC	$0	–	-4,750,000	–	-2.46%	–
PHAT	Exit	PHATHOM PHARMACEUTICALS INC	$0	–	-3,825,008	–	-2.57%	–
AXSM	Exit	AXSOME THERAPEUTICS INC	$0	–	-2,035,132	–	-2.65%	–
NKTX	Exit	NKARTA INC	$0	–	-5,605,129	–	-3.08%	–
TGTX	Exit	TG THERAPEUTICS INC	$0	–	-8,825,849	–	-4.32%	–
PCVX	Exit	VAXCYTE INC	$0	–	-5,283,818	–	-4.77%	–
CCXI	Exit	CHEMOCENTRYX INC	$0	–	-4,826,910	–	-4.84%	–
FMTX	Exit	FORMA THERAPEUTICS HLDGS INC	$0	–	-9,011,651	–	-8.22%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-5,909,742	–	-16.68%	–

Q3 2020

			Value		Shares		↓ Weighting
ASND	Buy	ASCENDIS PHARMA A Ssponsored adr	$911,991,000	+25.5%	5,909,742	+20.2%	16.68%	+17.8%
PCVX	Sell	VAXCYTE INC	$260,915,000	+50.4%	5,283,818	-3.7%	4.77%	+41.1%
TGTX	Sell	TG THERAPEUTICS INC	$236,180,000	-5.2%	8,825,849	-31.0%	4.32%	-11.0%
NKTX	New	NKARTA INC	$168,490,000	–	5,605,129	–	3.08%	–
MCRB	New	SERES THERAPEUTICS INC	$134,473,000	–	4,750,000	–	2.46%	–
NVAX	Sell	NOVAVAX INC	$129,869,000	-67.3%	1,198,602	-74.8%	2.38%	-69.3%
ETNB	Buy	89BIO INC	$121,531,000	+92.9%	4,736,214	+49.8%	2.22%	+81.0%
RYTM	Sell	RHYTHM PHARMACEUTICALS INC	$111,393,000	-4.1%	5,140,408	-1.3%	2.04%	-10.0%
MGNX	Sell	MACROGENICS INC	$110,212,000	-13.9%	4,375,217	-4.6%	2.02%	-19.2%
EIDX	Buy	EIDOS THERAPEUTICS INC	$109,310,000	+6.0%	2,163,271	+0.0%	2.00%	-0.5%
ITOS	New	ITEOS THERAPEUTICS INC	$108,974,000	–	4,417,258	–	1.99%	–
ZGNX	Buy	ZOGENIX INC	$98,407,000	-0.9%	5,488,424	+49.2%	1.80%	-7.0%
ADVM	Buy	ADVERUM BIOTECHNOLOGIES INC	$96,932,000	-40.5%	9,410,860	+20.6%	1.77%	-44.1%
ADAP	Sell	ADAPTIMMUNE THERAPEUTICS PLCsponds adr	$90,410,000	-30.8%	11,329,581	-13.2%	1.65%	-35.0%
LEGN	Sell	LEGEND BIOTECH CORPsponsored ads	$74,344,000	-29.6%	2,408,292	-3.0%	1.36%	-33.9%
VXRT	New	VAXART INC	$71,893,000	–	10,810,937	–	1.32%	–
PMVP	New	PMV PHARMACEUTICALS INC	$60,714,000	–	1,710,265	–	1.11%	–
DYN	New	DYNE THERAPEUTICS INC	$56,634,000	–	2,805,045	–	1.04%	–
INZY	New	INOZYME PHARMA INC	$52,676,000	–	2,003,653	–	0.96%	–
ORTX	Buy	ORCHARD THERAPEUTICS PLCads	$50,616,000	+10.8%	12,315,213	+18.4%	0.93%	+4.0%
CRDF	New	CARDIFF ONCOLOGY INC	$46,685,000	–	3,290,000	–	0.85%	–
RLAY	New	RELAY THERAPEUTICS INC	$42,590,000	–	1,000,000	–	0.78%	–
INBX	New	INHIBRX INC	$38,322,000	–	2,129,003	–	0.70%	–
ALEC	Sell	ALECTOR INC	$38,124,000	-62.2%	3,618,748	-12.3%	0.70%	-64.5%
VRNA	New	VERONA PHARMA PLCsponsored ads	$31,824,000	–	5,100,000	–	0.58%	–
RLMD	Sell	RELMADA THERAPEUTICS INC	$29,392,000	-22.9%	781,290	-8.3%	0.54%	-27.6%
IMGN	New	IMMUNOGEN INC	$25,346,000	–	7,040,485	–	0.46%	–
STRO	Buy	SUTRO BIOPHARMA INC	$21,288,000	+42.9%	2,118,212	+10.3%	0.39%	+34.1%
PAND	New	PANDION THERAPEUTICS INC	$20,284,000	–	1,770,023	–	0.37%	–
PRVL	Sell	PREVAIL THERAPEUTICS INC	$19,500,000	-47.5%	1,915,568	-23.2%	0.36%	-50.7%
MIST	New	MILESTONE PHARMACEUTICALS INC	$17,706,000	–	2,418,798	–	0.32%	–
BCTG	New	BCTG ACQUISITION CORP	$12,950,000	–	1,250,000	–	0.24%	–
FSDC	New	FS DEV CORP	$11,198,000	–	1,000,000	–	0.20%	–
ARYA	New	ARYA SCIENCES ACQUISITION CO	$10,815,000	–	1,000,000	–	0.20%	–
VSTM	Sell	VERASTEM INC	$9,760,000	-37.8%	8,066,171	-11.6%	0.18%	-41.5%
HSAQ	New	HEALTH SCIENCES ACQ CORP 2	$6,875,000	–	625,000	–	0.13%	–
CLDX	Sell	CELLDEX THERAPEUTICS INC NEW	$5,236,000	-65.0%	353,072	-69.3%	0.10%	-67.0%
IMRA	Sell	IMARA INC	$5,080,000	-77.8%	249,739	-69.9%	0.09%	-79.2%
EPIX	Sell	ESSA PHARMA INC	$3,246,000	-38.4%	470,428	-44.6%	0.06%	-42.7%
SELB	Exit	SELECTA BIOSCIENCES INC	$0	–	-95,000	–	-0.01%	–
INSM	Exit	INSMED INC	$0	–	-87,405	–	-0.05%	–
AVDL	Exit	AVADEL PHARMACEUTICALS PLCsponsored adr	$0	–	-3,126,131	–	-0.49%	–
STOK	Exit	STOKE THERAPEUTICS INC	$0	–	-1,119,963	–	-0.52%	–
MNTA	Exit	MOMENTA PHARMACEUTICALS INC	$0	–	-2,531,445	–	-1.64%	–

Q2 2020

			Value		Shares		↓ Weighting
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$726,922,000	–	4,914,955	–	14.16%	–
FMTX	New	FORMA THERAPEUTICS HLDGS INC	$418,952,000	–	9,011,651	–	8.16%	–
NVAX	New	NOVAVAX INC	$396,649,000	–	4,758,833	–	7.73%	–
CCXI	New	CHEMOCENTRYX INC	$277,740,000	–	4,826,910	–	5.41%	–
TGTX	New	TG THERAPEUTICS INC	$249,119,000	–	12,788,457	–	4.85%	–
PCVX	New	VAXCYTE INC	$173,513,000	–	5,489,181	–	3.38%	–
AXSM	New	AXSOME THERAPEUTICS INC	$167,451,000	–	2,035,132	–	3.26%	–
ADVM	New	ADVERUM BIOTECHNOLOGIES INC	$162,898,000	–	7,801,641	–	3.17%	–
STSA	New	SATSUMA PHARMACEUTICALS INC	$134,650,000	–	4,681,858	–	2.62%	–
ADAP	New	ADAPTIMMUNE THERAPEUTICS PLCsponds adr	$130,655,000	–	13,052,464	–	2.55%	–
MGNX	New	MACROGENICS INC	$128,003,000	–	4,584,652	–	2.49%	–
PHAT	New	PHATHOM PHARMACEUTICALS INC	$125,881,000	–	3,825,008	–	2.45%	–
ARVN	New	ARVINAS INC	$123,188,000	–	3,672,872	–	2.40%	–
RYTM	New	RHYTHM PHARMACEUTICALS INC	$116,185,000	–	5,210,088	–	2.26%	–
KALA	New	KALA PHARMACEUTICALS INC	$114,292,000	–	10,874,613	–	2.23%	–
BDTX	New	BLACK DIAMOND THERAPEUTICS INC	$109,190,000	–	2,589,904	–	2.13%	–
LEGN	New	LEGEND BIOTECH CORPsponsored ads	$105,631,000	–	2,481,942	–	2.06%	–
EIDX	New	EIDOS THERAPEUTICS INC	$103,095,000	–	2,162,671	–	2.01%	–
ALEC	New	ALECTOR INC	$100,872,000	–	4,127,348	–	1.97%	–
ZGNX	New	ZOGENIX INC	$99,327,000	–	3,677,424	–	1.94%	–
RTRX	New	RETROPHIN INC	$94,614,000	–	4,635,687	–	1.84%	–
MNTA	New	MOMENTA PHARMACEUTICALS INC	$84,221,000	–	2,531,445	–	1.64%	–
WVE	New	WAVE LIFE SCIENCES LTD	$80,940,000	–	7,775,207	–	1.58%	–
IGMS	New	IGM BIOSCIENCES INC	$71,739,000	–	982,723	–	1.40%	–
KROS	New	KEROS THERAPEUTICS INC	$70,331,000	–	1,875,000	–	1.37%	–
GERN	New	GERON CORP	$65,675,000	–	30,126,299	–	1.28%	–
ETNB	New	89BIO INC	$63,003,000	–	3,161,214	–	1.23%	–
AKUS	New	AKOUOS INC	$51,328,000	–	2,281,249	–	1.00%	–
	New	TRILLIUM THERAPEUTICS INC	$49,856,000	–	6,162,694	–	0.97%	–
ORTX	New	ORCHARD THERAPEUTICS PLCads	$45,688,000	–	10,403,187	–	0.89%	–
ARDX	New	ARDELYX INC	$43,325,000	–	6,260,904	–	0.84%	–
CRNX	New	CRINETICS PHARMACEUTICALS INC	$40,799,000	–	2,328,698	–	0.80%	–
RLMD	New	RELMADA THERAPEUTICS INC	$38,123,000	–	851,907	–	0.74%	–
PRVL	New	PREVAIL THERAPEUTICS INC	$37,171,000	–	2,494,691	–	0.72%	–
ARQT	New	ARCUTIS BIOTHERAPEUTICS INC	$35,235,000	–	1,165,184	–	0.69%	–
STOK	New	STOKE THERAPEUTICS INC	$26,689,000	–	1,119,963	–	0.52%	–
SCPH	New	SCPHARMACEUTICALS INC	$25,900,000	–	3,518,998	–	0.50%	–
AVDL	New	AVADEL PHARMACEUTICALS PLCsponsored adr	$25,259,000	–	3,126,131	–	0.49%	–
IMRA	New	IMARA INC	$22,915,000	–	829,348	–	0.45%	–
OCUL	New	OCULAR THERAPEUTIX INC	$22,718,000	–	2,727,272	–	0.44%	–
LRMR	New	LARIMAR THERAPEUTICS INC	$19,470,000	–	1,515,151	–	0.38%	–
CNCE	New	CONCERT PHARMACEUTICALS INC	$18,492,000	–	1,858,474	–	0.36%	–
VSTM	New	VERASTEM INC	$15,702,000	–	9,129,251	–	0.31%	–
SNDX	New	SYNDAX PHARMACEUTICALS INC	$15,162,000	–	1,023,067	–	0.30%	–
CLDX	New	CELLDEX THERAPEUTICS INC NEW	$14,950,000	–	1,150,000	–	0.29%	–
STRO	New	SUTRO BIOPHARMA INC	$14,896,000	–	1,919,644	–	0.29%	–
SLDB	New	SOLID BIOSCIENCES INC	$13,394,000	–	4,571,164	–	0.26%	–
RPTX	New	REPARE THERAPEUTICS INC	$12,687,000	–	409,000	–	0.25%	–
LYRA	New	LYRA THERAPEUTICS INC	$9,252,000	–	815,849	–	0.18%	–
PASG	New	PASSAGE BIO INC	$8,817,000	–	322,630	–	0.17%	–
ARYBU	New	ARYA SCIENCES ACQUISITION CORPunit 06/09/2027	$8,117,000	–	700,000	–	0.16%	–
GRTX	New	GALERA THERAPEUTICS INC	$5,891,000	–	825,118	–	0.12%	–
EPIX	New	ESSA PHARMA INC	$5,266,000	–	849,300	–	0.10%	–
XFOR	New	X4 PHARMACEUTICALS INC	$5,214,000	–	559,494	–	0.10%	–
INSM	New	INSMED INC	$2,407,000	–	87,405	–	0.05%	–
OVID	New	OVID THERAPEUTICS INC	$2,100,000	–	285,000	–	0.04%	–
SELB	New	SELECTA BIOSCIENCES INC	$270,000	–	95,000	–	0.01%	–

Q4 2019

			Value		Shares		↓ Weighting
SENS	Exit	SENSEONICS HLDGS INC	$0	–	-2,727,273	–	-0.16%	–
EPIX	Exit	ESSA PHARMA INC	$0	–	-1,000,000	–	-0.20%	–
CMRX	Exit	CHIMERIX INC	$0	–	-1,782,202	–	-0.25%	–
ODT	Exit	ODONATE THERAPEUTICS INC	$0	–	-200,000	–	-0.31%	–
XFOR	Exit	X4 PHARMACEUTICALS INC	$0	–	-478,107	–	-0.36%	–
IGMS	Exit	IGM BIOSCIENCES INC	$0	–	-466,368	–	-0.49%	–
DVAX	Exit	DYNAVAX TECHNOLOGIES CORP	$0	–	-2,365,912	–	-0.50%	–
PTLA	Exit	PORTOLA PHARMACEUTICALS INC	$0	–	-429,399	–	-0.69%	–
AXSM	Exit	AXSOME THERAPEUTICS INC	$0	–	-664,385	–	-0.80%	–
ALEC	Exit	ALECTOR INC	$0	–	-1,000,000	–	-0.86%	–
KOD	Exit	KODIAK SCIENCES INC	$0	–	-1,025,165	–	-0.88%	–
DTIL	Exit	PRECISION BIOSCIENCES INC	$0	–	-1,842,366	–	-0.92%	–
KALA	Exit	KALA PHARMACEUTICALS INC	$0	–	-4,537,478	–	-1.03%	–
SCPH	Exit	SCPHARMACEUTICALS INC	$0	–	-3,247,005	–	-1.14%	–
STOK	Exit	STOKE THERAPEUTICS INC	$0	–	-1,119,963	–	-1.43%	–
CRNX	Exit	CRINETICS PHARMACEUTICALS INC	$0	–	-1,875,209	–	-1.68%	–
MYOV	Exit	MYOVANT SCIENCES LTD	$0	–	-6,166,875	–	-1.91%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-2,456,669	–	-2.10%	–
ARVN	Exit	ARVINAS INC	$0	–	-1,663,512	–	-2.14%	–
TGTX	Exit	TG THERAPEUTICS INC	$0	–	-6,880,323	–	-2.30%	–
PRVL	Exit	PREVAIL THERAPEUTICS INC	$0	–	-3,363,605	–	-2.46%	–
RTRX	Exit	RETROPHIN INC	$0	–	-3,987,560	–	-2.75%	–
SLDB	Exit	SOLID BIOSCIENCES INC	$0	–	-4,571,164	–	-2.82%	–
ORTX	Exit	ORCHARD THERAPEUTICS PLCads	$0	–	-5,224,475	–	-3.70%	–
STSA	Exit	SATSUMA PHARMACEUTICALS INC	$0	–	-4,681,858	–	-4.19%	–
RYTM	Exit	RHYTHM PHARMACEUTICALS INC	$0	–	-3,422,312	–	-4.40%	–
EIDX	Exit	EIDOS THERAPEUTICS INC	$0	–	-2,162,671	–	-4.64%	–
ZGNX	Exit	ZOGENIX INC	$0	–	-2,260,751	–	-5.39%	–
RARX	Exit	RA PHARMACEUTICALS INC	$0	–	-4,858,260	–	-6.85%	–
THOR	Exit	SYNTHORX INC	$0	–	-9,724,598	–	-9.43%	–
WVE	Exit	WAVE LIFE SCIENCES LTD	$0	–	-7,775,207	–	-9.51%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-4,132,442	–	-23.72%	–

Q3 2019

			Value		Shares		↓ Weighting
ZGNX	Sell	ZOGENIX INC	$90,520,000	-49.1%	2,260,751	-39.3%	5.39%	-43.5%
RYTM	Buy	RHYTHM PHARMACEUTICALS INC	$73,888,000	+78.2%	3,422,312	+81.6%	4.40%	+97.8%
STSA	New	SATSUMA PHARMACEUTICALS INC	$70,275,000	–	4,681,858	–	4.19%	–
ORTX	Buy	ORCHARD THERAPEUTICS PLCads	$62,067,000	-13.2%	5,224,475	+2.3%	3.70%	-3.6%
SLDB	Buy	SOLID BIOSCIENCES INC	$47,266,000	+122.0%	4,571,164	+70.0%	2.82%	+146.4%
RTRX	New	RETROPHIN INC	$46,216,000	–	3,987,560	–	2.75%	–
PRVL	Buy	PREVAIL THERAPEUTICS INC	$41,305,000	+14.1%	3,363,605	+22.6%	2.46%	+26.6%
ARVN	Sell	ARVINAS INC	$35,849,000	-3.4%	1,663,512	-1.5%	2.14%	+7.2%
MYOV	Sell	MYOVANT SCIENCES LTD	$32,068,000	-45.9%	6,166,875	-5.8%	1.91%	-39.9%
KOD	New	KODIAK SCIENCES INC	$14,742,000	–	1,025,165	–	0.88%	–
AXSM	Sell	AXSOME THERAPEUTICS INC	$13,447,000	-61.1%	664,385	-50.4%	0.80%	-56.8%
PTLA	New	PORTOLA PHARMACEUTICALS INC	$11,516,000	–	429,399	–	0.69%	–
DVAX	New	DYNAVAX TECHNOLOGIES CORP	$8,458,000	–	2,365,912	–	0.50%	–
IGMS	New	IGM BIOSCIENCES INC	$8,278,000	–	466,368	–	0.49%	–
XFOR	Sell	X4 PHARMACEUTICALS INC	$6,077,000	-53.0%	478,107	-44.5%	0.36%	-47.8%
CMRX	New	CHIMERIX INC	$4,188,000	–	1,782,202	–	0.25%	–
EPIX	New	ESSA PHARMA INC	$3,370,000	–	1,000,000	–	0.20%	–
SENS	New	SENSEONICS HLDGS INC	$2,696,000	–	2,727,273	–	0.16%	–
GTHX	Exit	G1 THERAPEUTICS INC	$0	–	-483,990	–	-0.80%	–
SWAV	Exit	SHOCKWAVE MED INC	$0	–	-495,608	–	-1.52%	–

Q2 2019

			Value		Shares		↓ Weighting
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$475,851,000	–	4,132,442	–	25.54%	–
WVE	New	WAVE LIFE SCIENCES LTD	$202,855,000	–	7,775,207	–	10.89%	–
ZGNX	New	ZOGENIX INC	$177,861,000	–	3,722,504	–	9.55%	–
RARX	New	RA PHARMACEUTICALS INC	$136,959,000	–	4,858,260	–	7.35%	–
THOR	New	SYNTHORX INC	$131,379,000	–	9,724,598	–	7.05%	–
EIDX	New	EIDOS THERAPEUTICS INC	$112,726,000	–	2,162,671	–	6.05%	–
ORTX	New	ORCHARD THERAPEUTICS PLCads	$71,466,000	–	5,108,330	–	3.84%	–
TGTX	New	TG THERAPEUTICS INC	$59,515,000	–	6,880,323	–	3.20%	–
MYOV	New	MYOVANT SCIENCES LTD	$59,238,000	–	6,545,642	–	3.18%	–
CRNX	New	CRINETICS PHARMACEUTICALS INC	$46,880,000	–	1,875,209	–	2.52%	–
RYTM	New	RHYTHM PHARMACEUTICALS INC	$41,465,000	–	1,884,782	–	2.23%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$38,693,000	–	2,456,669	–	2.08%	–
ARVN	New	ARVINAS INC	$37,128,000	–	1,688,412	–	1.99%	–
PRVL	New	PREVAIL THERAPEUTICS INC	$36,216,000	–	2,743,625	–	1.94%	–
AXSM	New	AXSOME THERAPEUTICS INC	$34,526,000	–	1,340,828	–	1.85%	–
STOK	New	STOKE THERAPEUTICS INC	$32,669,000	–	1,119,963	–	1.75%	–
KALA	New	KALA PHARMACEUTICALS INC	$28,949,000	–	4,537,478	–	1.55%	–
SWAV	New	SHOCKWAVE MED INC	$28,294,000	–	495,608	–	1.52%	–
DTIL	New	PRECISION BIOSCIENCES INC	$24,411,000	–	1,842,366	–	1.31%	–
SLDB	New	SOLID BIOSCIENCES INC	$21,293,000	–	2,689,444	–	1.14%	–
ALEC	New	ALECTOR INC	$19,000,000	–	1,000,000	–	1.02%	–
GTHX	New	G1 THERAPEUTICS INC	$14,839,000	–	483,990	–	0.80%	–
XFOR	New	X4 PHARMACEUTICALS INC	$12,921,000	–	861,393	–	0.69%	–
SCPH	New	SCPHARMACEUTICALS INC	$10,358,000	–	3,247,005	–	0.56%	–
ODT	New	ODONATE THERAPEUTICS INC	$7,338,000	–	200,000	–	0.39%	–

Q4 2018

			Value		Shares		↓ Weighting
PRTO	Exit	PROTEON THERAPEUTICS INC	$0	–	-1,337,462	–	-0.14%	–
GLYC	Exit	GLYCOMIMETICS INC	$0	–	-253,547	–	-0.20%	–
IOVA	Exit	IOVANCE BIOTHERAPEUTICS INC	$0	–	-1,121,153	–	-0.67%	–
APLS	Exit	APELLIS PHARMACEUTICALS INC	$0	–	-900,000	–	-0.86%	–
SCPH	Exit	SCPHARMACEUTICALS INC	$0	–	-2,857,143	–	-0.90%	–
PGNX	Exit	PROGENICS PHARMACEUTICALS INC	$0	–	-3,030,303	–	-1.02%	–
KALA	Exit	KALA PHARMACEUTICALS INC	$0	–	-2,113,236	–	-1.12%	–
EIDX	Exit	EIDOS THERAPEUTICS INC	$0	–	-2,162,671	–	-1.15%	–
KALV	Exit	KALVISTA PHARMACEUTICALS INC	$0	–	-1,441,070	–	-1.70%	–
MNTA	Exit	MOMENTA PHARMACEUTICALS INC	$0	–	-1,558,357	–	-2.19%	–
TGTX	Exit	TG THERAPEUTICS INC	$0	–	-8,198,337	–	-2.45%	–
CRNX	Exit	CRINETICS PHARMACEUTICALS INC	$0	–	-1,701,017	–	-2.60%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-350,933	–	-2.65%	–
ARVN	Exit	ARVINAS INC	$0	–	-3,138,412	–	-2.83%	–
RYTM	Exit	RHYTHM PHARMACEUTICALS INC	$0	–	-1,950,332	–	-3.04%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-3,933,489	–	-3.21%	–
IMMU	Exit	IMMUNOMEDICS INC	$0	–	-3,119,778	–	-3.47%	–
IFRX	Exit	INFLARX NV	$0	–	-1,967,848	–	-3.61%	–
RARX	Exit	RA PHARMACEUTICALS INC	$0	–	-3,851,808	–	-3.72%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALS	$0	–	-9,234,692	–	-3.77%	–
MYOV	Exit	MYOVANT SCIENCES LTD	$0	–	-3,451,859	–	-4.90%	–
ZGNX	Exit	ZOGENIX INC	$0	–	-1,878,768	–	-4.98%	–
ECYT	Exit	ENDOCYTE INC	$0	–	-6,196,143	–	-5.88%	–
SLDB	Exit	SOLID BIOSCIENCES INC	$0	–	-2,689,444	–	-6.78%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-4,240,536	–	-16.06%	–
WVE	Exit	WAVE LIFE SCIENCES LTD	$0	–	-7,512,049	–	-20.08%	–

Q3 2018

			Value		Shares		↓ Weighting
ECYT	Buy	ENDOCYTE INC	$110,043,000	+41.1%	6,196,143	+9.7%	5.88%	+16.2%
ZGNX	Buy	ZOGENIX INC	$93,187,000	+84.1%	1,878,768	+64.0%	4.98%	+51.6%
MYOV	Buy	MYOVANT SCIENCES LTD	$91,647,000	+41.6%	3,451,859	+22.0%	4.90%	+16.6%
BCRX	Buy	BIOCRYST PHARMACEUTICALS	$70,461,000	+76.1%	9,234,692	+32.2%	3.77%	+45.0%
IFRX	Buy	INFLARX NV	$67,537,000	+6.5%	1,967,848	+0.0%	3.61%	-12.3%
RYTM	Buy	RHYTHM PHARMACEUTICALS INC	$56,891,000	+18.0%	1,950,332	+26.5%	3.04%	-2.8%
ARVN	New	ARVINAS INC	$52,945,000	–	3,138,412	–	2.83%	–
CRNX	New	CRINETICS PHARMACEUTICALS INC	$48,734,000	–	1,701,017	–	2.60%	–
TGTX	Buy	TG THERAPEUTICS INC	$45,911,000	-18.4%	8,198,337	+91.6%	2.45%	-32.8%
MNTA	Sell	MOMENTA PHARMACEUTICALS INC	$40,985,000	-45.9%	1,558,357	-57.9%	2.19%	-55.4%
PGNX	New	PROGENICS PHARMACEUTICALS INC	$19,000,000	–	3,030,303	–	1.02%	–
GTHX	Exit	G1 THERAPEUTICS INC	$0	–	-40,000	–	-0.11%	–
SPRO	Exit	SPERO THERAPEUTICS INC	$0	–	-741,647	–	-0.71%	–
AVEO	Exit	AVEO PHARMACEUTICALS INC	$0	–	-5,062,759	–	-0.74%	–
CLSD	Exit	CLEARSIDE BIOMEDICAL INC	$0	–	-1,525,000	–	-1.06%	–

Q2 2018

			Value		Shares		↓ Weighting
WVE	New	WAVE LIFE SCIENCES LTD	$287,336,000	–	7,512,049	–	18.66%	–
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$282,080,000	–	4,240,536	–	18.31%	–
SLDB	New	SOLID BIOSCIENCES INC	$95,825,000	–	2,689,444	–	6.22%	–
ECYT	New	ENDOCYTE INC	$77,968,000	–	5,649,884	–	5.06%	–
MNTA	New	MOMENTA PHARMACEUTICALS INC	$75,717,000	–	3,702,533	–	4.92%	–
IMMU	New	IMMUNOMEDICS INC	$73,845,000	–	3,119,778	–	4.79%	–
MYOV	New	MYOVANT SCIENCES LTD	$64,733,000	–	2,830,455	–	4.20%	–
IFRX	New	INFLARX NV	$63,441,000	–	1,967,148	–	4.12%	–
TGTX	New	TG THERAPEUTICS INC	$56,266,000	–	4,278,796	–	3.65%	–
SAGE	New	SAGE THERAPEUTICS INC	$54,932,000	–	350,933	–	3.57%	–
ZGNX	New	ZOGENIX INC	$50,621,000	–	1,145,268	–	3.29%	–
RYTM	New	RHYTHM PHARMACEUTICALS INC	$48,195,000	–	1,541,743	–	3.13%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$48,185,000	–	3,933,489	–	3.13%	–
EIDX	New	EIDOS THERAPEUTICS INC	$43,989,000	–	2,162,671	–	2.86%	–
BCRX	New	BIOCRYST PHARMACEUTICALS	$40,022,000	–	6,984,692	–	2.60%	–
RARX	New	RA PHARMACEUTICALS INC	$38,325,000	–	3,851,808	–	2.49%	–
KALA	New	KALA PHARMACEUTICALS INC	$29,015,000	–	2,113,236	–	1.88%	–
APLS	New	APELLIS PHARMACEUTICALS INC	$19,800,000	–	900,000	–	1.29%	–
CLSD	New	CLEARSIDE BIOMEDICAL INC	$16,302,000	–	1,525,000	–	1.06%	–
SCPH	New	SCPHARMACEUTICALS INC	$16,171,000	–	2,857,143	–	1.05%	–
IOVA	New	IOVANCE BIOTHERAPEUTICS INC	$14,351,000	–	1,121,153	–	0.93%	–
KALV	New	KALVISTA PHARMACEUTICALS INC	$11,701,000	–	1,441,070	–	0.76%	–
AVEO	New	AVEO PHARMACEUTICALS INC	$11,442,000	–	5,062,759	–	0.74%	–
SPRO	New	SPERO THERAPEUTICS INC	$10,880,000	–	741,647	–	0.71%	–
GLYC	New	GLYCOMIMETICS INC	$4,090,000	–	253,547	–	0.27%	–
PRTO	New	PROTEON THERAPEUTICS INC	$3,277,000	–	1,337,462	–	0.21%	–
GTHX	New	G1 THERAPEUTICS INC	$1,738,000	–	40,000	–	0.11%	–

Q4 2017

			Value		Shares		↓ Weighting
PRTO	Exit	PROTEON THERAPEUTICS INC	$0	–	-1,337,462	–	-0.24%	–
CHMA	Exit	CHIASMA INC	$0	–	-1,396,400	–	-0.32%	–
KALV	Exit	KALVISTA PHARMACEUTICALS INC	$0	–	-591,070	–	-0.39%	–
VNDA	Exit	VANDA PHARMACEUTICALS INC	$0	–	-243,971	–	-0.40%	–
KRYS	Exit	KRYSTAL BIOTECH INC	$0	–	-700,000	–	-0.63%	–
TGTX	Exit	TG THERAPEUTICS INC	$0	–	-700,000	–	-0.75%	–
CMTA	Exit	CLEMENTIA PHARMACEUTICALS INC COM NPV	$0	–	-585,403	–	-0.89%	–
	Exit	AQUINOX PHARMACEUTICALS INC	$0	–	-710,682	–	-0.91%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-2,428,571	–	-1.26%	–
SGMO	Exit	SANGAMO THERAPEUTICS INC	$0	–	-1,250,000	–	-1.69%	–
RARX	Exit	RA PHARMACEUTICALS INC	$0	–	-1,351,808	–	-1.78%	–
IMMU	Exit	IMMUNOMEDICS INC	$0	–	-1,478,742	–	-1.87%	–
ACOR	Exit	ACORDA THERAPEUTICS INC	$0	–	-900,259	–	-1.92%	–
KDMN	Exit	KADMON HLDGS INC	$0	–	-6,666,666	–	-2.02%	–
INSM	Exit	INSMED INC	$0	–	-722,714	–	-2.04%	–
ZGNX	Exit	ZOGENIX INC	$0	–	-992,268	–	-3.14%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALS	$0	–	-6,984,692	–	-3.31%	–
AVEO	Exit	AVEO PHARMACEUTICALS INC	$0	–	-11,328,646	–	-3.74%	–
MYOV	Exit	MYOVANT SCIENCES LTD	$0	–	-2,830,455	–	-3.96%	–
KALA	Exit	KALA PHARMACEUTICALS INC	$0	–	-2,113,236	–	-4.36%	–
GTHX	Exit	G1 THERAPEUTICS INC	$0	–	-2,684,244	–	-4.50%	–
RXDX	Exit	IGNYTA INC	$0	–	-4,106,601	–	-4.58%	–
ACHN	Exit	ACHILLION PHARMACEUTICALS INC	$0	–	-13,633,220	–	-5.53%	–
BHVN	Exit	BIOHAVEN PHARMACTL HLDG CO LTD	$0	–	-1,997,278	–	-6.74%	–
AVXS	Exit	AVEXIS INC	$0	–	-1,238,181	–	-10.82%	–
WVE	Exit	WAVE LIFE SCIENCES LTD	$0	–	-7,088,651	–	-13.93%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-5,580,690	–	-18.28%	–

Q3 2017

			Value		Shares		↓ Weighting
AVXS	Sell	AVEXIS INC	$119,769,000	+11.3%	1,238,181	-5.5%	10.82%	-12.4%
BHVN	Sell	BIOHAVEN PHARMACTL HLDG CO LTD	$74,658,000	+22.0%	1,997,278	-18.4%	6.74%	-4.0%
RXDX	Buy	IGNYTA INC	$50,717,000	+22.0%	4,106,601	+2.2%	4.58%	-4.0%
KALA	New	KALA PHARMACEUTICALS INC	$48,266,000	–	2,113,236	–	4.36%	–
MYOV	Buy	MYOVANT SCIENCES LTD	$43,787,000	+33.3%	2,830,455	+0.8%	3.96%	+5.0%
AVEO	Buy	AVEO PHARMACEUTICALS INC	$41,350,000	+120.8%	11,328,646	+34.3%	3.74%	+73.8%
BCRX	Buy	BIOCRYST PHARMACEUTICALS	$36,600,000	+27.5%	6,984,692	+35.3%	3.31%	+0.4%
ZGNX	Sell	ZOGENIX INC	$34,779,000	+62.6%	992,268	-32.7%	3.14%	+28.0%
INSM	New	INSMED INC	$22,556,000	–	722,714	–	2.04%	–
KDMN	New	KADMON HLDGS INC	$22,333,000	–	6,666,666	–	2.02%	–
IMMU	New	IMMUNOMEDICS INC	$20,673,000	–	1,478,742	–	1.87%	–
	New	AQUINOX PHARMACEUTICALS INC	$10,085,000	–	710,682	–	0.91%	–
CMTA	New	CLEMENTIA PHARMACEUTICALS INC COM NPV	$9,887,000	–	585,403	–	0.89%	–
KRYS	New	KRYSTAL BIOTECH INC	$6,979,000	–	700,000	–	0.63%	–
VNDA	New	VANDA PHARMACEUTICALS INC	$4,367,000	–	243,971	–	0.40%	–
CHMA	New	CHIASMA INC	$3,561,000	–	1,396,400	–	0.32%	–
AKBA	Exit	AKEBIA THERAPEUTICS INC	$0	–	-836,337	–	-1.38%	–
AQXP	Exit	AQUINOX PHARMACEUTICALS INC	$0	–	-1,396,071	–	-2.25%	–
RDUS	Exit	RADIUS HEALTH INC	$0	–	-497,157	–	-2.58%	–
ESPR	Exit	ESPERION THERAPEUTICS INC	$0	–	-731,531	–	-3.88%	–

Q2 2017

			Value		Shares		↓ Weighting
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$154,920,000	–	5,580,690	–	17.78%	–
WVE	New	WAVE LIFE SCIENCES LTD	$131,849,000	–	7,088,651	–	15.13%	–
AVXS	New	AVEXIS INC	$107,633,000	–	1,310,046	–	12.35%	–
ACHN	New	ACHILLION PHARMACEUTICALS INC	$62,576,000	–	13,633,220	–	7.18%	–
BHVN	New	BIOHAVEN PHARMACTL HLDG CO LTD	$61,209,000	–	2,448,350	–	7.02%	–
GTHX	New	G1 THERAPEUTICS INC	$46,813,000	–	2,684,244	–	5.37%	–
RXDX	New	IGNYTA INC	$41,576,000	–	4,016,990	–	4.77%	–
ESPR	New	ESPERION THERAPEUTICS INC	$33,855,000	–	731,531	–	3.88%	–
MYOV	New	MYOVANT SCIENCES LTD	$32,848,000	–	2,807,550	–	3.77%	–
BCRX	New	BIOCRYST PHARMACEUTICALS	$28,702,000	–	5,162,242	–	3.29%	–
RARX	New	RA PHARMACEUTICALS INC	$25,333,000	–	1,351,808	–	2.91%	–
RDUS	New	RADIUS HEALTH INC	$22,486,000	–	497,157	–	2.58%	–
ZGNX	New	ZOGENIX INC	$21,383,000	–	1,474,688	–	2.45%	–
AQXP	New	AQUINOX PHARMACEUTICALS INC	$19,643,000	–	1,396,071	–	2.25%	–
AVEO	New	AVEO PHARMACEUTICALS INC	$18,727,000	–	8,435,584	–	2.15%	–
ACOR	New	ACORDA THERAPEUTICS INC	$17,735,000	–	900,259	–	2.04%	–
AKBA	New	AKEBIA THERAPEUTICS INC	$12,018,000	–	836,337	–	1.38%	–
SGMO	New	SANGAMO THERAPEUTICS INC	$11,000,000	–	1,250,000	–	1.26%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$7,699,000	–	2,428,571	–	0.88%	–
TGTX	New	TG THERAPEUTICS INC	$7,035,000	–	700,000	–	0.81%	–
KALV	New	KALVISTA PHARMACEUTICALS INC	$4,350,000	–	591,070	–	0.50%	–
PRTO	New	PROTEON THERAPEUTICS INC	$2,040,000	–	1,337,462	–	0.23%	–

Q4 2016

			Value		Shares		↓ Weighting
AKTX	Exit	AKARI THERAPEUTICS PLCsponsored adr	$0	–	-114,039	–	-0.10%	–
ABIO	Exit	ARCA BIOPHARMA INC	$0	–	-521,606	–	-0.15%	–
AGLE	Exit	AEGLEA BIOTHERAPEUTICS INC	$0	–	-336,134	–	-0.22%	–
SGMO	Exit	SANGAMO BIOSCIENCES INC	$0	–	-899,438	–	-0.43%	–
EIGR	Exit	EIGER BIOPHARMACEUTICALS INC	$0	–	-354,200	–	-0.49%	–
ADHD	Exit	ALCOBRA LTD	$0	–	-2,044,756	–	-0.52%	–
BGNE	Exit	BEIGENE LTDsponsored adr	$0	–	-170,000	–	-0.54%	–
TENX	Exit	TENAX THERAPEUTICS INC	$0	–	-2,389,700	–	-0.57%	–
ARWR	Exit	ARROWHEAD PHARMACEUTICALS INC	$0	–	-1,525,424	–	-1.16%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-318,565	–	-1.19%	–
DMTX	Exit	DIMENSION THERAPEUTICS INC	$0	–	-1,548,033	–	-1.28%	–
BOLD	Exit	AUDENTES THERAPEUTICS INC	$0	–	-707,426	–	-1.30%	–
SBBP	Exit	STRONGBRIDGE BIOPHARMA PLC	$0	–	-2,501,667	–	-1.35%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALS	$0	–	-2,989,795	–	-1.36%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-2,428,571	–	-1.47%	–
PRTO	Exit	PROTEON THERAPEUTICS INC	$0	–	-1,626,931	–	-1.57%	–
PTGX	Exit	PROTAGONIST THERAPEUTICS INC	$0	–	-754,411	–	-1.64%	–
FOMX	Exit	FOAMIX PHARMACEUTICALS LTD	$0	–	-1,820,138	–	-1.74%	–
AIMT	Exit	AIMMUNE THERAPEUTICS INC	$0	–	-1,292,940	–	-2.00%	–
AQXP	Exit	AQUINOX PHARMACEUTICALS INC	$0	–	-2,191,977	–	-3.02%	–
ZGNX	Exit	ZOGENIX INC	$0	–	-2,656,166	–	-3.24%	–
TGTX	Exit	TG THERAPEUTICS INC	$0	–	-4,631,114	–	-3.70%	–
ACRS	Exit	ACLARIS THERAPEUTICS INC	$0	–	-1,547,152	–	-4.09%	–
ARDX	Exit	ARDELYX INC	$0	–	-3,266,045	–	-4.36%	–
NKTR	Exit	NEKTAR THERAPEUTICS	$0	–	-3,664,154	–	-6.49%	–
AXGT	Exit	AXOVANT SCIENCES LTD	$0	–	-5,000,000	–	-7.22%	–
AVXS	Exit	AVEXIS INC	$0	–	-1,732,274	–	-7.36%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-3,681,491	–	-7.63%	–
ACHN	Exit	ACHILLION PHARMACEUTICALS INC	$0	–	-12,033,220	–	-10.06%	–
WVE	Exit	WAVE LIFE SCIENCES PTE LTD	$0	–	-7,088,651	–	-23.74%	–

Q3 2016

			Value		Shares		↓ Weighting
ASND	Buy	ASCENDIS PHARMA A Ssponsored adr	$73,998,000	+63.4%	3,681,491	+7.9%	7.63%	+21.7%
AVXS	Buy	AVEXIS INC	$71,387,000	+40.2%	1,732,274	+29.3%	7.36%	+4.4%
NKTR	Buy	NEKTAR THERAPEUTICS	$62,950,000	+37.2%	3,664,154	+13.6%	6.49%	+2.2%
ARDX	Buy	ARDELYX INC	$42,263,000	+109.4%	3,266,045	+41.3%	4.36%	+56.0%
ACRS	Sell	ACLARIS THERAPEUTICS INC	$39,623,000	-18.4%	1,547,152	-41.1%	4.09%	-39.2%
TGTX	Buy	TG THERAPEUTICS INC	$35,845,000	+30.5%	4,631,114	+2.2%	3.70%	-2.7%
ZGNX	Buy	ZOGENIX INC	$31,451,000	+59.4%	2,656,166	+8.4%	3.24%	+18.7%
AQXP	Buy	AQUINOX PHARMACEUTICALS INC	$29,285,000	+161.4%	2,191,977	+29.6%	3.02%	+94.8%
FOMX	New	FOAMIX PHARMACEUTICALS LTD	$16,854,000	–	1,820,138	–	1.74%	–
PTGX	New	PROTAGONIST THERAPEUTICS INC	$15,941,000	–	754,411	–	1.64%	–
SBBP	Sell	STRONGBRIDGE BIOPHARMA PLC	$13,059,000	+22.6%	2,501,667	-6.5%	1.35%	-8.6%
BOLD	New	AUDENTES THERAPEUTICS INC	$12,599,000	–	707,426	–	1.30%	–
XLRN	New	ACCELERON PHARMA INC	$11,529,000	–	318,565	–	1.19%	–
ARWR	New	ARROWHEAD PHARMACEUTICALS INC	$11,212,000	–	1,525,424	–	1.16%	–
ADHD	Sell	ALCOBRA LTD	$5,051,000	-62.9%	2,044,756	-32.6%	0.52%	-72.4%
EIGR	Buy	EIGER BIOPHARMACEUTICALS INC	$4,743,000	-18.0%	354,200	+21.4%	0.49%	-38.9%
SGMO	Sell	SANGAMO BIOSCIENCES INC	$4,164,000	-38.3%	899,438	-22.9%	0.43%	-54.0%
AGLE	Sell	AEGLEA BIOTHERAPEUTICS INC	$2,155,000	-15.0%	336,134	-35.6%	0.22%	-36.8%
ABIO	Sell	ARCA BIOPHARMA INC	$1,476,000	-9.6%	521,606	-7.3%	0.15%	-32.7%
AKTX	Sell	AKARI THERAPEUTICS PLCsponsored adr	$970,000	-69.3%	114,039	-51.3%	0.10%	-77.2%
DNAI	Exit	PRONAI THERAPEUTICS INC	$0	–	-29,719	–	-0.01%	–
ZYNE	Exit	ZYNERBA PHARMACEUTICALS INC	$0	–	-253,468	–	-0.24%	–
MRUS	Exit	MERUS N V	$0	–	-237,599	–	-0.26%	–
CDTX	Exit	CIDARA THERAPEUTICS INC	$0	–	-410,809	–	-0.59%	–
AGRX	Exit	AGILE THERAPEUTICS INC	$0	–	-853,151	–	-0.90%	–
NTRA	Exit	NATERA INC	$0	–	-783,520	–	-1.31%	–
VTAE	Exit	VITAE PHARMACEUTICALS INC	$0	–	-1,575,000	–	-2.35%	–

Q2 2016

			Value		Shares		↓ Weighting
WVE	New	WAVE LIFE SCIENCES LTD	$146,664,000	–	7,088,651	–	20.31%	–
ACHN	New	ACHILLION PHARMACEUTICALS INC	$93,859,000	–	12,033,220	–	13.00%	–
AXGT	New	AXOVANT SCIENCES LTD	$64,200,000	–	5,000,000	–	8.89%	–
AVXS	New	AVEXIS INC	$50,923,000	–	1,339,382	–	7.05%	–
ACRS	New	ACLARIS THERAPEUTICS INC	$48,534,000	–	2,627,719	–	6.72%	–
NKTR	New	NEKTAR THERAPEUTICS	$45,890,000	–	3,224,854	–	6.35%	–
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$45,289,000	–	3,412,857	–	6.27%	–
TGTX	New	TG THERAPEUTICS INC	$27,462,000	–	4,531,714	–	3.80%	–
ARDX	New	ARDELYX INC	$20,186,000	–	2,312,243	–	2.80%	–
ZGNX	New	ZOGENIX INC	$19,732,000	–	2,451,237	–	2.73%	–
VTAE	New	VITAE PHARMACEUTICALS INC	$16,994,000	–	1,575,000	–	2.35%	–
AIMT	New	AIMMUNE THERAPEUTICS INC	$13,990,000	–	1,292,940	–	1.94%	–
ADHD	New	ALCOBRA LTD	$13,618,000	–	3,032,911	–	1.89%	–
PRTO	New	PROTEON THERAPEUTICS INC	$13,064,000	–	1,626,931	–	1.81%	–
AQXP	New	AQUINOX PHARMACEUTICALS INC	$11,201,000	–	1,691,977	–	1.55%	–
SBBP	New	STRONGBRIDGE BIOPHARMA PLC	$10,648,000	–	2,675,338	–	1.47%	–
NTRA	New	NATERA INC	$9,453,000	–	783,520	–	1.31%	–
DMTX	New	DIMENSION THERAPEUTICS INC	$9,288,000	–	1,548,033	–	1.29%	–
BCRX	New	BIOCRYST PHARMACEUTICALS	$8,491,000	–	2,989,795	–	1.18%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$7,286,000	–	2,428,571	–	1.01%	–
SGMO	New	SANGAMO BIOSCIENCES INC	$6,751,000	–	1,165,938	–	0.94%	–
AGRX	New	AGILE THERAPEUTICS INC	$6,492,000	–	853,151	–	0.90%	–
TENX	New	TENAX THERAPEUTICS INC	$6,118,000	–	2,389,700	–	0.85%	–
EIGR	New	EIGER BIOPHARMACEUTICALS INC	$5,781,000	–	291,700	–	0.80%	–
BGNE	New	BEIGENE LTDsponsored adr	$5,066,000	–	170,000	–	0.70%	–
CDTX	New	CIDARA THERAPEUTICS INC	$4,235,000	–	410,809	–	0.59%	–
AKTX	New	AKARI THERAPEUTICS PLCsponsored adr	$3,160,000	–	234,240	–	0.44%	–
AGLE	New	AEGLEA BIOTHERAPEUTICS INC	$2,535,000	–	521,550	–	0.35%	–
MRUS	New	MERUS N V	$1,898,000	–	237,599	–	0.26%	–
ZYNE	New	ZYNERBA PHARMACEUTICALS INC	$1,736,000	–	253,468	–	0.24%	–
ABIO	New	ARCA BIOPHARMA INC	$1,632,000	–	562,693	–	0.23%	–
DNAI	New	PRONAI THERAPEUTICS INC	$59,000	–	29,719	–	0.01%	–

Q4 2015

			Value		Shares		↓ Weighting
APHB	Exit	AMPLIPHI BIOSCIENCES CORP	$0	–	-65,100	–	-0.04%	–
WGBS	Exit	WAFERGEN BIO-SYSTEMS INC	$0	–	-205,400	–	-0.04%	–
DRRX	Exit	DURECT CORP	$0	–	-381,800	–	-0.11%	–
BNTC	Exit	BENITEC BIOPHARMA LTDspons adr new	$0	–	-140,548	–	-0.12%	–
VICL	Exit	VICAL INC	$0	–	-2,084,078	–	-0.14%	–
NVAX	Exit	NOVAVAX INC	$0	–	-162,060	–	-0.16%	–
AGTC	Exit	APPLIED GENETIC TECHNOL CORP	$0	–	-121,100	–	-0.23%	–
EARS	Exit	AURIS MED HLDG AG	$0	–	-467,572	–	-0.24%	–
EPZM	Exit	EPIZYME INC	$0	–	-227,092	–	-0.42%	–
VTAE	Exit	VITAE PHARMACEUTICALS INC	$0	–	-321,161	–	-0.51%	–
ABIO	Exit	ARCA BIOPHARMA INC	$0	–	-811,227	–	-0.58%	–
AGRX	Exit	AGILE THERAPEUTICS INC	$0	–	-630,702	–	-0.61%	–
BLCM	Exit	BELLICUM PHARMACEUTICALS INC	$0	–	-315,704	–	-0.66%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INC	$0	–	-63,026	–	-0.73%	–
RARE	Exit	ULTRAGENYX PHARMACEUTICAL INC	$0	–	-56,067	–	-0.78%	–
AKTX	Exit	AKARI THERAPEUTICS PLCsponsored adr	$0	–	-263,921	–	-0.91%	–
MCRB	Exit	SERES THERAPEUTICS INC	$0	–	-246,645	–	-1.05%	–
ZYNE	Exit	ZYNERBA PHARMACEUTICALS INC	$0	–	-525,000	–	-1.08%	–
NVLS	Exit	NIVALIS THERAPEUTICS INC	$0	–	-612,863	–	-1.14%	–
TENX	Exit	TENAX THERAPEUTICS INC	$0	–	-2,670,300	–	-1.15%	–
SGMO	Exit	SANGAMO BIOSCIENCES INC	$0	–	-1,445,430	–	-1.17%	–
XNCR	Exit	XENCOR INC	$0	–	-679,885	–	-1.19%	–
NTRA	Exit	NATERA INC	$0	–	-783,521	–	-1.22%	–
	Exit	NEURODERM LTD	$0	–	-425,000	–	-1.26%	–
TXMD	Exit	THERAPEUTICSMD INC	$0	–	-1,518,460	–	-1.28%	–
ADHD	Exit	ALCOBRA LTD	$0	–	-1,832,911	–	-1.59%	–
DNAI	Exit	PRONAI THERAPEUTICS INC	$0	–	-604,982	–	-1.78%	–
ITCI	Exit	INTRA CELLULAR THERAPIES INC	$0	–	-314,349	–	-1.81%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALS	$0	–	-1,196,603	–	-1.96%	–
BLUE	Exit	BLUEBIRD BIO INC	$0	–	-167,367	–	-2.06%	–
CDTX	Exit	CIDARA THERAPEUTICS INC	$0	–	-1,180,570	–	-2.16%	–
ARDX	Exit	ARDELYX INC	$0	–	-1,064,013	–	-2.64%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-878,348	–	-2.69%	–
GBT	Exit	GLOBAL BLOOD THERAPEUTICS INC	$0	–	-457,142	–	-2.77%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-2,428,571	–	-2.86%	–
AIMT	Exit	AIMMUNE THERAPEUTICS INC	$0	–	-790,200	–	-2.87%	–
PRTO	Exit	PROTEON THERAPEUTICS INC	$0	–	-1,506,872	–	-3.01%	–
AQXP	Exit	AQUINOX PHARMACEUTICALS INC	$0	–	-1,532,151	–	-3.10%	–
ZGNX	Exit	ZOGENIX INC	$0	–	-1,679,500	–	-3.26%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-1,461,268	–	-3.71%	–
CHRS	Exit	COHERUS BIOSCIENCES INC	$0	–	-1,305,020	–	-3.76%	–
RGLS	Exit	REGULUS THERAPEUTICS INC	$0	–	-4,039,823	–	-3.79%	–
TGTX	Exit	TG THERAPEUTICS INC	$0	–	-3,124,480	–	-4.52%	–
COLL	Exit	COLLEGIUM PHARMACEUTICAL INC	$0	–	-1,553,175	–	-4.93%	–
DYAX	Exit	DYAX CORP	$0	–	-2,551,193	–	-6.99%	–
AXGT	Exit	AXOVANT SCIENCES LTD	$0	–	-5,000,000	–	-9.28%	–
ACHN	Exit	ACHILLION PHARMACEUTICALS INC	$0	–	-11,733,815	–	-11.64%	–

Q3 2015

			Value		Shares		↓ Weighting
ACHN	Buy	ACHILLION PHARMACEUTICALS INC	$81,081,000	-8.0%	11,733,815	+18.0%	11.64%	+31.4%
DYAX	Sell	DYAX CORP	$48,702,000	-32.0%	2,551,193	-5.6%	6.99%	-2.9%
COLL	Buy	COLLEGIUM PHARMACEUTICAL INC	$34,341,000	+24.6%	1,553,175	+0.5%	4.93%	+77.9%
TGTX	Sell	TG THERAPEUTICS INC	$31,495,000	-42.5%	3,124,480	-5.4%	4.52%	-17.9%
RGLS	Buy	REGULUS THERAPEUTICS INC	$26,420,000	-36.4%	4,039,823	+6.6%	3.79%	-9.2%
CHRS	Sell	COHERUS BIOSCIENCES INC	$26,153,000	-34.4%	1,305,020	-5.5%	3.76%	-6.4%
ASND	Sell	ASCENDIS PHARMA A Ssponsored adr	$25,864,000	-23.5%	1,461,268	-23.6%	3.71%	+9.1%
ZGNX	New	ZOGENIX INC	$22,673,000	–	1,679,500	–	3.26%	–
AQXP	New	AQUINOX PHARMACEUTICALS INC	$21,557,000	–	1,532,151	–	3.10%	–
AIMT	New	AIMMUNE THERAPEUTICS INC	$20,008,000	–	790,200	–	2.87%	–
GBT	New	GLOBAL BLOOD THERAPEUTICS INC	$19,273,000	–	457,142	–	2.77%	–
ARDX	Sell	ARDELYX INC	$18,386,000	-33.1%	1,064,013	-38.1%	2.64%	-4.4%
CDTX	Buy	CIDARA THERAPEUTICS INC	$15,017,000	-6.1%	1,180,570	+3.4%	2.16%	+34.0%
BLUE	Buy	BLUEBIRD BIO INC	$14,318,000	-22.3%	167,367	+53.0%	2.06%	+11.0%
BCRX	Sell	BIOCRYST PHARMACEUTICALS	$13,641,000	-64.9%	1,196,603	-54.1%	1.96%	-49.9%
ITCI	New	INTRA CELLULAR THERAPIES INC	$12,587,000	–	314,349	–	1.81%	–
DNAI	New	PRONAI THERAPEUTICS INC	$12,414,000	–	604,982	–	1.78%	–
ADHD	Buy	ALCOBRA LTD	$11,071,000	+10.9%	1,832,911	+20.1%	1.59%	+58.4%
TXMD	Sell	THERAPEUTICSMD INC	$8,898,000	-32.6%	1,518,460	-9.6%	1.28%	-3.8%
	New	NEURODERM LTD	$8,785,000	–	425,000	–	1.26%	–
NTRA	New	NATERA INC	$8,501,000	–	783,521	–	1.22%	–
XNCR	Sell	XENCOR INC	$8,315,000	-64.8%	679,885	-36.8%	1.19%	-49.8%
SGMO	Buy	SANGAMO BIOSCIENCES INC	$8,152,000	-39.8%	1,445,430	+18.5%	1.17%	-14.0%
NVLS	Sell	NIVALIS THERAPEUTICS INC	$7,949,000	-30.7%	612,863	-19.1%	1.14%	-1.0%
ZYNE	New	ZYNERBA PHARMACEUTICALS INC	$7,513,000	–	525,000	–	1.08%	–
AKTX	New	AKARI THERAPEUTICS PLCsponsored adr	$6,333,000	–	263,921	–	0.91%	–
RARE	New	ULTRAGENYX PHARMACEUTICAL INC	$5,400,000	–	56,067	–	0.78%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$5,065,000	–	63,026	–	0.73%	–
BLCM	Sell	BELLICUM PHARMACEUTICALS INC	$4,587,000	-79.0%	315,704	-69.2%	0.66%	-70.0%
AGRX	Sell	AGILE THERAPEUTICS INC	$4,251,000	-66.1%	630,702	-56.8%	0.61%	-51.5%
ABIO	New	ARCA BIOPHARMA INC	$4,024,000	–	811,227	–	0.58%	–
VTAE	New	VITAE PHARMACEUTICALS INC	$3,536,000	–	321,161	–	0.51%	–
EPZM	New	EPIZYME INC	$2,920,000	–	227,092	–	0.42%	–
EARS	Sell	AURIS MED HLDG AG	$1,665,000	-63.6%	467,572	-50.3%	0.24%	-48.0%
AGTC	New	APPLIED GENETIC TECHNOL CORP	$1,591,000	–	121,100	–	0.23%	–
NVAX	Sell	NOVAVAX INC	$1,146,000	-92.8%	162,060	-88.7%	0.16%	-89.7%
VICL	Sell	VICAL INC	$958,000	-47.5%	2,084,078	-20.1%	0.14%	-25.0%
BNTC	New	BENITEC BIOPHARMA LTDspons adr new	$864,000	–	140,548	–	0.12%	–
APHB	New	AMPLIPHI BIOSCIENCES CORP	$257,000	–	65,100	–	0.04%	–
PBYI	Exit	PUMA BIOTECHNOLOGY INC	$0	–	-3,100	–	-0.04%	–
KERX	Exit	KERYX BIOPHARMACEUTICALS INC	$0	–	-59,200	–	-0.06%	–
ARRY	Exit	ARRAY BIOPHARMA INC	$0	–	-126,095	–	-0.09%	–
AMGN	Exit	AMGEN INC	$0	–	-5,900	–	-0.09%	–
CELG	Exit	CELGENE CORP	$0	–	-8,700	–	-0.10%	–
BIIB	Exit	BIOGEN INC	$0	–	-2,600	–	-0.11%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INC	$0	–	-9,900	–	-0.11%	–
INCY	Exit	INCYTE CORP	$0	–	-10,700	–	-0.11%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INC	$0	–	-27,300	–	-0.12%	–
CLVS	Exit	CLOVIS ONCOLOGY INC	$0	–	-13,200	–	-0.12%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-24,400	–	-0.12%	–
ALKS	Exit	ALKERMES PLC	$0	–	-19,200	–	-0.12%	–
PTCT	Exit	PTC THERAPEUTICS INC	$0	–	-25,800	–	-0.12%	–
REGN	Exit	REGENERON PHARMACEUTICALS	$0	–	-2,450	–	-0.13%	–
NLNK	Exit	NEWLINK GENETICS CORP	$0	–	-30,000	–	-0.13%	–
TSRO	Exit	TESARO INC	$0	–	-23,500	–	-0.14%	–
MACK	Exit	MERRIMACK PHARMACEUTICALS IN	$0	–	-116,400	–	-0.14%	–
BOTA	Exit	BIOTA PHARMACEUTIALS INC	$0	–	-807,855	–	-0.17%	–
TTOO	Exit	T2 BIOSYSTEMS INC	$0	–	-138,002	–	-0.22%	–
TRVN	Exit	TREVENA INC	$0	–	-528,118	–	-0.33%	–
AUPH	Exit	AURINIA PHARMACEUTICALS INC	$0	–	-1,142,676	–	-0.35%	–
ABIO	Exit	ARCA BIOPHARMA INC	$0	–	-5,678,592	–	-0.66%	–
SCMP	Exit	SUCAMPO PHARMACEUTICALS INCcl a	$0	–	-450,000	–	-0.74%	–
CNCE	Exit	CONCERT PHARMACEUTICALS INC	$0	–	-668,406	–	-1.00%	–
OMER	Exit	OMEROS CORP	$0	–	-749,000	–	-1.36%	–
AGEN	Exit	AGENUS INC	$0	–	-1,600,000	–	-1.39%	–
JUNO	Exit	JUNO THERAPEUTICS INC	$0	–	-280,000	–	-1.50%	–
DVAX	Exit	DYNAVAX TECHNOLOGIES CORP	$0	–	-766,000	–	-1.80%	–
MDCO	Exit	MEDICINES CO	$0	–	-705,925	–	-2.03%	–
SGMO	Exit	SANGAMO BIOSCIENCES INCcall	$0	–	-6,000,000	–	-6.69%	–

Q2 2015

			Value		Shares		↓ Weighting
AXGT	New	AXOVANT SCIENCES LTD	$101,900,000	–	5,000,000	–	10.25%	–
ACHN	New	ACHILLION PHARMACEUTICALS INC	$88,122,000	–	9,945,997	–	8.86%	–
DYAX	New	DYAX CORP	$71,632,000	–	2,703,093	–	7.21%	–
SGMO	New	SANGAMO BIOSCIENCES INCcall	$66,540,000	–	6,000,000	–	6.69%	–
TGTX	New	TG THERAPEUTICS INC	$54,784,000	–	3,302,213	–	5.51%	–
RGLS	New	REGULUS THERAPEUTICS INC	$41,544,000	–	3,790,476	–	4.18%	–
CHRS	New	COHERUS BIOSCIENCES INC	$39,891,000	–	1,380,320	–	4.01%	–
BCRX	New	BIOCRYST PHARMACEUTICALS	$38,898,000	–	2,605,361	–	3.91%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$33,879,000	–	2,428,571	–	3.41%	–
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$33,825,000	–	1,913,153	–	3.40%	–
COLL	New	COLLEGIUM PHARMACEUTICAL INC	$27,570,000	–	1,545,410	–	2.77%	–
ARDX	New	ARDELYX INC	$27,468,000	–	1,719,945	–	2.76%	–
PRTO	New	PROTEON THERAPEUTICS INC	$26,913,000	–	1,506,872	–	2.71%	–
XNCR	New	XENCOR INC	$23,627,000	–	1,075,410	–	2.38%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$23,267,000	–	878,348	–	2.34%	–
BLCM	New	BELLICUM PHARMACEUTICALS INC	$21,832,000	–	1,026,402	–	2.20%	–
MDCO	New	MEDICINES CO	$20,197,000	–	705,925	–	2.03%	–
BLUE	New	BLUEBIRD BIO INC	$18,417,000	–	109,383	–	1.85%	–
DVAX	New	DYNAVAX TECHNOLOGIES CORP	$17,944,000	–	766,000	–	1.80%	–
CDTX	New	CIDARA THERAPEUTICS INC	$16,001,000	–	1,141,333	–	1.61%	–
NVAX	New	NOVAVAX INC	$15,944,000	–	1,431,232	–	1.60%	–
JUNO	New	JUNO THERAPEUTICS INC	$14,932,000	–	280,000	–	1.50%	–
AGEN	New	AGENUS INC	$13,808,000	–	1,600,000	–	1.39%	–
SGMO	New	SANGAMO BIOSCIENCES INC	$13,532,000	–	1,220,209	–	1.36%	–
OMER	New	OMEROS CORP	$13,475,000	–	749,000	–	1.36%	–
TXMD	New	THERAPEUTICSMD INC	$13,208,000	–	1,680,395	–	1.33%	–
AGRX	New	AGILE THERAPEUTICS INC	$12,531,000	–	1,458,792	–	1.26%	–
NVLS	New	NIVALIS THERAPEUTICS INC	$11,473,000	–	757,263	–	1.15%	–
MCRB	New	SERES THERAPEUTICS INC	$10,236,000	–	246,645	–	1.03%	–
ADHD	New	ALCOBRA LTD	$9,979,000	–	1,525,894	–	1.00%	–
CNCE	New	CONCERT PHARMACEUTICALS INC	$9,953,000	–	668,406	–	1.00%	–
TENX	New	TENAX THERAPEUTICS INC	$9,853,000	–	2,670,300	–	0.99%	–
SCMP	New	SUCAMPO PHARMACEUTICALS INCcl a	$7,394,000	–	450,000	–	0.74%	–
ABIO	New	ARCA BIOPHARMA INC	$6,530,000	–	5,678,592	–	0.66%	–
EARS	New	AURIS MED HLDG AG	$4,568,000	–	940,000	–	0.46%	–
AUPH	New	AURINIA PHARMACEUTICALS INC	$3,451,000	–	1,142,676	–	0.35%	–
TRVN	New	TREVENA INC	$3,306,000	–	528,118	–	0.33%	–
TTOO	New	T2 BIOSYSTEMS INC	$2,240,000	–	138,002	–	0.22%	–
VICL	New	VICAL INC	$1,825,000	–	2,606,978	–	0.18%	–
BOTA	New	BIOTA PHARMACEUTIALS INC	$1,672,000	–	807,855	–	0.17%	–
MACK	New	MERRIMACK PHARMACEUTICALS IN	$1,439,000	–	116,400	–	0.14%	–
TSRO	New	TESARO INC	$1,382,000	–	23,500	–	0.14%	–
NLNK	New	NEWLINK GENETICS CORP	$1,328,000	–	30,000	–	0.13%	–
REGN	New	REGENERON PHARMACEUTICALS	$1,250,000	–	2,450	–	0.13%	–
PTCT	New	PTC THERAPEUTICS INC	$1,242,000	–	25,800	–	0.12%	–
ALKS	New	ALKERMES PLC	$1,235,000	–	19,200	–	0.12%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$1,165,000	–	24,400	–	0.12%	–
CLVS	New	CLOVIS ONCOLOGY INC	$1,160,000	–	13,200	–	0.12%	–
ACAD	New	ACADIA PHARMACEUTICALS INC	$1,143,000	–	27,300	–	0.12%	–
INCY	New	INCYTE CORP	$1,115,000	–	10,700	–	0.11%	–
AGIO	New	AGIOS PHARMACEUTICALS INC	$1,100,000	–	9,900	–	0.11%	–
BIIB	New	BIOGEN INC	$1,050,000	–	2,600	–	0.11%	–
CELG	New	CELGENE CORP	$1,007,000	–	8,700	–	0.10%	–
DRRX	New	DURECT CORP	$913,000	–	381,800	–	0.09%	–
AMGN	New	AMGEN INC	$906,000	–	5,900	–	0.09%	–
ARRY	New	ARRAY BIOPHARMA INC	$909,000	–	126,095	–	0.09%	–
WGBS	New	WAFERGEN BIO-SYSTEMS INC	$647,000	–	205,400	–	0.06%	–
KERX	New	KERYX BIOPHARMACEUTICALS INC	$591,000	–	59,200	–	0.06%	–
PBYI	New	PUMA BIOTECHNOLOGY INC	$362,000	–	3,100	–	0.04%	–

Q4 2014

			Value		Shares		↓ Weighting
NLNK	Exit	NEWLINK GENETICS CORP	$0	–	-30,000	–	-0.08%	–
PBYI	Exit	PUMA BIOTECHNOLOGY INC	$0	–	-3,100	–	-0.09%	–
KYTH	Exit	KYTHERA BIOPHARMACEUTICALS	$0	–	-22,750	–	-0.09%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INC	$0	–	-30,000	–	-0.09%	–
KERX	Exit	KERYX BIOPHARMACEUTICALS INC	$0	–	-59,200	–	-0.10%	–
ALKS	Exit	ALKERMES PLC	$0	–	-19,200	–	-0.10%	–
CELG	Exit	CELGENE CORP	$0	–	-8,700	–	-0.10%	–
AMGN	Exit	AMGEN INC	$0	–	-5,900	–	-0.10%	–
BIIB	Exit	BIOGEN IDEC INC	$0	–	-2,600	–	-0.10%	–
REGN	Exit	REGENERON PHARMACEUTICALS	$0	–	-2,450	–	-0.10%	–
RGEN	Exit	REPLIGEN CORP	$0	–	-45,000	–	-0.11%	–
MACK	Exit	MERRIMACK PHARMACEUTICALS INC	$0	–	-116,400	–	-0.12%	–
VRTX	Exit	VERTEX PHARMACEUTICALS INC	$0	–	-9,300	–	-0.12%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INC	$0	–	-17,600	–	-0.13%	–
PTCT	Exit	PTC THERAPEUTICS INC	$0	–	-25,800	–	-0.13%	–
CDXS	Exit	CODEXIS INC	$0	–	-504,279	–	-0.14%	–
ALIM	Exit	ALIMERA SCIENCES INC	$0	–	-243,726	–	-0.16%	–
OCRX	Exit	OCERA THERAPEUTICS INC	$0	–	-417,476	–	-0.24%	–
WGBS	Exit	WAFERGEN BIO-SYSTEMS INC	$0	–	-560,000	–	-0.29%	–
TTOO	Exit	T2 BIOSYSTEMS INC	$0	–	-138,002	–	-0.30%	–
EARS	Exit	AURIS MED HLDG AG	$0	–	-940,000	–	-0.64%	–
VICL	Exit	VICAL INC	$0	–	-5,475,419	–	-0.72%	–
SCYX	Exit	SCYNEXIS INC	$0	–	-840,000	–	-0.73%	–
TENX	Exit	TENAX THERAPEUTICS INC	$0	–	-2,336,375	–	-1.08%	–
ENTA	Exit	ENANTA PHARMACEUTICALS INC	$0	–	-250,000	–	-1.17%	–
XNCR	Exit	XENCOR INC	$0	–	-1,248,923	–	-1.37%	–
SGMO	Exit	SANGAMO BIOSCIENCES INC	$0	–	-1,220,209	–	-1.56%	–
AKBA	Exit	AKEBIA THERAPEUTICS INC	$0	–	-597,363	–	-1.56%	–
ZFGN	Exit	ZAFGEN INC	$0	–	-732,960	–	-1.70%	–
TXMD	Exit	THERAPEUTICSMD INC	$0	–	-3,454,332	–	-1.89%	–
VSAR	Exit	VERSARTIS INC	$0	–	-898,993	–	-2.02%	–
DVAX	Exit	DYNAVAX TECHNOLOGIES CORP	$0	–	-12,179,002	–	-2.06%	–
NVAX	Exit	NOVAVAX INC	$0	–	-5,067,083	–	-2.50%	–
TGTX	Exit	TG THERAPEUTICS INC	$0	–	-2,065,571	–	-2.60%	–
ZSPH	Exit	ZS PHARMA INC	$0	–	-564,483	–	-2.62%	–
OPHT	Exit	OPHTHOTECH CORP	$0	–	-588,941	–	-2.71%	–
BLUE	Exit	BLUEBIRD BIO INC	$0	–	-728,812	–	-3.09%	–
ACHN	Exit	ACHILLION PHARMACEUTICALS INcall	$0	–	-3,000,000	–	-3.54%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-2,428,571	–	-3.65%	–
SNSS	Exit	SUNESIS PHARMACEUTICALS INC	$0	–	-4,869,261	–	-4.11%	–
AVNR	Exit	AVANIR PHARMACEUTICALS INCcl a new	$0	–	-5,386,700	–	-7.59%	–
SGMO	Exit	SANGAMO BIOSCIENCES INCcall	$0	–	-6,000,000	–	-7.65%	–
ACHN	Exit	ACHILLION PHARMACEUTICALS INC	$0	–	-6,700,000	–	-7.90%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALS	$0	–	-7,069,159	–	-8.17%	–
DYAX	Exit	DYAX CORP	$0	–	-7,809,139	–	-9.34%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INCcall	$0	–	-5,250,000	–	-15.36%	–

Q3 2014

			Value		Shares		↓ Weighting
DYAX	Sell	DYAX CORP	$79,028,000	-17.5%	7,809,139	-21.8%	9.34%	-3.6%
BCRX	Buy	BIOCRYST PHARMACEUTICALS	$69,136,000	+69.5%	7,069,159	+121.0%	8.17%	+98.2%
ACHN	Sell	ACHILLION PHARMACEUTICALS INC	$66,866,000	-60.7%	6,700,000	-70.2%	7.90%	-54.1%
AVNR	New	AVANIR PHARMACEUTICALS INCcl a new	$64,209,000	–	5,386,700	–	7.59%	–
BLUE	Buy	BLUEBIRD BIO INC	$26,150,000	+34.8%	728,812	+44.9%	3.09%	+57.6%
OPHT	Buy	OPHTHOTECH CORP	$22,927,000	+2.6%	588,941	+11.6%	2.71%	+20.0%
ZSPH	New	ZS PHARMA INC	$22,145,000	–	564,483	–	2.62%	–
TGTX	New	TG THERAPEUTICS INC	$22,040,000	–	2,065,571	–	2.60%	–
NVAX	Sell	NOVAVAX INC	$21,130,000	-31.3%	5,067,083	-23.9%	2.50%	-19.7%
DVAX	Sell	DYNAVAX TECHNOLOGIES CORP	$17,416,000	-22.5%	12,179,002	-13.2%	2.06%	-9.3%
VSAR	Sell	VERSARTIS INC	$17,072,000	-65.9%	898,993	-25.3%	2.02%	-60.2%
TXMD	Sell	THERAPEUTICSMD INC	$16,028,000	-15.7%	3,454,332	-19.7%	1.89%	-1.5%
ZFGN	New	ZAFGEN INC	$14,403,000	–	732,960	–	1.70%	–
SGMO	Sell	SANGAMO BIOSCIENCES INC	$13,160,000	-69.1%	1,220,209	-56.3%	1.56%	-63.9%
XNCR	Buy	XENCOR INC	$11,627,000	-1.6%	1,248,923	+22.8%	1.37%	+15.1%
ENTA	Sell	ENANTA PHARMACEUTICALS INC	$9,893,000	-85.1%	250,000	-83.8%	1.17%	-82.6%
TENX	New	TENAX THERAPEUTICS INC	$9,182,000	–	2,336,375	–	1.08%	–
VICL	New	VICAL INC	$6,132,000	–	5,475,419	–	0.72%	–
EARS	New	AURIS MED HLDG AG	$5,424,000	–	940,000	–	0.64%	–
TTOO	New	T2 BIOSYSTEMS INC	$2,496,000	–	138,002	–	0.30%	–
WGBS	New	WAFERGEN BIO-SYSTEMS INC	$2,436,000	–	560,000	–	0.29%	–
OCRX	Sell	OCERA THERAPEUTICS INC	$2,046,000	-45.4%	417,476	-14.9%	0.24%	-36.1%
ALIM	Sell	ALIMERA SCIENCES INC	$1,321,000	-66.9%	243,726	-63.4%	0.16%	-61.3%
CDXS	New	CODEXIS INC	$1,175,000	–	504,279	–	0.14%	–
PTCT	New	PTC THERAPEUTICS INC	$1,135,000	–	25,800	–	0.13%	–
AGIO	New	AGIOS PHARMACEUTICALS INC	$1,080,000	–	17,600	–	0.13%	–
VRTX	New	VERTEX PHARMACEUTICALS INC	$1,044,000	–	9,300	–	0.12%	–
MACK	New	MERRIMACK PHARMACEUTICALS INC	$1,022,000	–	116,400	–	0.12%	–
RGEN	New	REPLIGEN CORP	$896,000	–	45,000	–	0.11%	–
REGN	New	REGENERON PHARMACEUTICALS	$883,000	–	2,450	–	0.10%	–
BIIB	New	BIOGEN IDEC INC	$860,000	–	2,600	–	0.10%	–
AMGN	New	AMGEN INC	$829,000	–	5,900	–	0.10%	–
ALKS	New	ALKERMES PLC	$823,000	–	19,200	–	0.10%	–
CELG	New	CELGENE CORP	$825,000	–	8,700	–	0.10%	–
KERX	New	KERYX BIOPHARMACEUTICALS INC	$814,000	–	59,200	–	0.10%	–
ACAD	New	ACADIA PHARMACEUTICALS INC	$743,000	–	30,000	–	0.09%	–
KYTH	New	KYTHERA BIOPHARMACEUTICALS	$745,000	–	22,750	–	0.09%	–
PBYI	New	PUMA BIOTECHNOLOGY INC	$740,000	–	3,100	–	0.09%	–
NLNK	New	NEWLINK GENETICS CORP	$643,000	–	30,000	–	0.08%	–
PRAN	Exit	PRANA BIOTECHNOLOGY LTDcall	$0	–	-100,000	–	-0.02%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-68,968	–	-0.10%	–
OXBT	Exit	OXYGEN BIOTHERAPEUTICS INC	$0	–	-315,298	–	-0.13%	–
IMMU	Exit	IMMUNOMEDICS INC	$0	–	-1,000,000	–	-0.37%	–
ARWR	Exit	ARROWHEAD RESH CORP	$0	–	-604,346	–	-0.87%	–
PSDV	Exit	PSIVIDA CORP	$0	–	-2,555,659	–	-1.12%	–
RPRX	Exit	REPROS THERAPEUTICS INC	$0	–	-1,219,381	–	-2.13%	–

Q2 2014

			Value		Shares		↓ Weighting
ACHN	New	ACHILLION PHARMACEUTICALS INC	$170,219,000	–	22,486,007	–	17.21%	–
ACAD	New	ACADIA PHARMACEUTICALS INCcall	$118,598,000	–	5,250,000	–	11.99%	–
DYAX	New	DYAX CORP	$95,833,000	–	9,982,578	–	9.69%	–
SGMO	New	SANGAMO BIOSCIENCES INCcall	$91,620,000	–	6,000,000	–	9.26%	–
ENTA	New	ENANTA PHARMACEUTICALS INC	$66,310,000	–	1,539,586	–	6.70%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$54,813,000	–	2,428,571	–	5.54%	–
VSAR	New	VERSARTIS INC	$50,107,000	–	1,203,002	–	5.06%	–
SGMO	New	SANGAMO BIOSCIENCES INC	$42,623,000	–	2,791,305	–	4.31%	–
BCRX	New	BIOCRYST PHARMACEUTICALS	$40,781,000	–	3,198,529	–	4.12%	–
SNSS	New	SUNESIS PHARMACEUTICALS INC	$31,748,000	–	4,869,261	–	3.21%	–
NVAX	New	NOVAVAX INC	$30,777,000	–	6,661,731	–	3.11%	–
ACHN	New	ACHILLION PHARMACEUTICALS INcall	$22,710,000	–	3,000,000	–	2.30%	–
DVAX	New	DYNAVAX TECHNOLOGIES CORP	$22,459,000	–	14,036,590	–	2.27%	–
OPHT	New	OPHTHOTECH CORP	$22,337,000	–	527,941	–	2.26%	–
RPRX	New	REPROS THERAPEUTICS INC	$21,095,000	–	1,219,381	–	2.13%	–
BLUE	New	BLUEBIRD BIO INC	$19,403,000	–	503,062	–	1.96%	–
TXMD	New	THERAPEUTICSMD INC	$19,020,000	–	4,303,066	–	1.92%	–
AKBA	New	AKEBIA THERAPEUTICS INC	$16,601,000	–	597,363	–	1.68%	–
XNCR	New	XENCOR INC	$11,814,000	–	1,016,735	–	1.19%	–
PSDV	New	PSIVIDA CORP	$11,092,000	–	2,555,659	–	1.12%	–
ARWR	New	ARROWHEAD RESH CORP	$8,648,000	–	604,346	–	0.87%	–
SCYX	New	SCYNEXIS INC	$6,737,000	–	840,000	–	0.68%	–
ALIM	New	ALIMERA SCIENCES INC	$3,987,000	–	666,667	–	0.40%	–
OCRX	New	OCERA THERAPEUTICS INC	$3,749,000	–	490,697	–	0.38%	–
IMMU	New	IMMUNOMEDICS INC	$3,650,000	–	1,000,000	–	0.37%	–
OXBT	New	OXYGEN BIOTHERAPEUTICS INC	$1,286,000	–	315,298	–	0.13%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$1,023,000	–	68,968	–	0.10%	–
PRAN	New	PRANA BIOTECHNOLOGY LTDcall	$227,000	–	100,000	–	0.02%	–

Q4 2013

			Value		Shares		↓ Weighting
	Exit	SAVIENT PHARMACEUTICALS INCnote 4.750% 2/0	$0	–	-1,000,000	–	-0.02%	–
EPZM	Exit	EPIZYME INC	$0	–	-10,000	–	-0.04%	–
OCRX	Exit	OCERA THERAPEUTICS INC	$0	–	-215,999	–	-0.19%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INC	$0	–	-70,000	–	-0.20%	–
TGTX	Exit	TG THERAPEUTICS INC	$0	–	-600,000	–	-0.32%	–
DYAX	Exit	DYAX CORPcall	$0	–	-500,000	–	-0.36%	–
ARWR	Exit	ARROWHEAD RESH CORP	$0	–	-879,561	–	-0.52%	–
PTCT	Exit	PTC THERAPEUTICS INC	$0	–	-300,000	–	-0.67%	–
CNDO	Exit	CORONADO BIOSCIENCES INCcall	$0	–	-1,000,000	–	-0.73%	–
OGXI	Exit	ONCOGENEX PHARMACEUTICALS IN	$0	–	-763,332	–	-0.74%	–
DVAX	Exit	DYNAVAX TECHNOLOGIES CORP	$0	–	-6,000,000	–	-0.74%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-551,723	–	-0.87%	–
ENZ	Exit	ENZO BIOCHEM INC	$0	–	-3,348,029	–	-0.88%	–
NLNK	Exit	NEWLINK GENETICS CORPcall	$0	–	-500,000	–	-0.98%	–
AMPE	Exit	AMPIO PHARMACEUTICALS INC	$0	–	-1,325,566	–	-1.04%	–
KERX	Exit	KERYX BIOPHARMACEUTICALS INCcall	$0	–	-1,000,000	–	-1.05%	–
OMER	Exit	OMEROS CORP	$0	–	-1,055,311	–	-1.07%	–
MYGN	Exit	MYRIAD GENETICS INC	$0	–	-450,000	–	-1.10%	–
RMTI	Exit	ROCKWELL MED INCput	$0	–	-1,000,000	–	-1.19%	–
BLUE	Exit	BLUEBIRD BIO INC	$0	–	-467,418	–	-1.32%	–
ACHN	Exit	ACHILLION PHARMACEUTICALS INcall	$0	–	-5,500,000	–	-1.73%	–
CCXI	Exit	CHEMOCENTRYX INC	$0	–	-3,045,380	–	-1.77%	–
HPTX	Exit	HYPERION THERAPEUTICS INC	$0	–	-902,858	–	-2.46%	–
KERX	Exit	KERYX BIOPHARMACEUTICALS INC	$0	–	-2,391,261	–	-2.52%	–
SNSS	Exit	SUNESIS PHARMACEUTICALS INC	$0	–	-4,869,261	–	-2.52%	–
DSCI	Exit	DERMA SCIENCES INC	$0	–	-1,994,876	–	-2.58%	–
XOMA	Exit	XOMA CORP DEL	$0	–	-6,915,525	–	-3.24%	–
SGMO	Exit	SANGAMO BIOSCIENCES INCcall	$0	–	-3,000,000	–	-3.28%	–
PRTA	Exit	PROTHENA CORP PLC	$0	–	-1,646,399	–	-3.48%	–
NLNK	Exit	NEWLINK GENETICS CORP	$0	–	-1,840,294	–	-3.61%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALS	$0	–	-5,844,700	–	-4.44%	–
ACHN	Exit	ACHILLION PHARMACEUTICALS IN	$0	–	-14,457,061	–	-4.56%	–
SGMO	Exit	SANGAMO BIOSCIENCES INC	$0	–	-4,258,244	–	-4.66%	–
INSM	Exit	INSMED INC	$0	–	-2,983,319	–	-4.86%	–
TXMD	Exit	THERAPEUTICSMD INC	$0	–	-16,528,641	–	-5.06%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INC	$0	–	-2,035,510	–	-5.84%	–
NVAX	Exit	NOVAVAX INC	$0	–	-20,800,000	–	-6.84%	–
DYAX	Exit	DYAX CORP	$0	–	-10,418,379	–	-7.46%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INCcall	$0	–	-5,250,000	–	-15.05%	–

Q3 2013

			Value		Shares		↓ Weighting
ACAD	Buy	ACADIA PHARMACEUTICALS INCcall	$144,218,000	+58.9%	5,250,000	+5.0%	15.05%	+25.1%
DYAX	Sell	DYAX CORP	$71,470,000	+89.4%	10,418,379	-4.5%	7.46%	+49.0%
NVAX	Buy	NOVAVAX INC	$65,520,000	+86.1%	20,800,000	+21.1%	6.84%	+46.5%
ACAD	Sell	ACADIA PHARMACEUTICALS INC	$55,915,000	-52.8%	2,035,510	-68.8%	5.84%	-62.9%
TXMD	Buy	THERAPEUTICSMD INC	$48,429,000	+41.9%	16,528,641	+46.8%	5.06%	+11.7%
INSM	Buy	INSMED INC	$46,570,000	+60.0%	2,983,319	+22.6%	4.86%	+25.9%
SGMO	Sell	SANGAMO BIOSCIENCES INC	$44,669,000	+6.5%	4,258,244	-20.7%	4.66%	-16.2%
ACHN	Buy	ACHILLION PHARMACEUTICALS IN	$43,660,000	-28.4%	14,457,061	+93.9%	4.56%	-43.7%
BCRX	New	BIOCRYST PHARMACEUTICALS	$42,549,000	–	5,844,700	–	4.44%	–
PRTA	Buy	PROTHENA CORP PLC	$33,307,000	+418.2%	1,646,399	+230.7%	3.48%	+308.0%
XOMA	Buy	XOMA CORP DEL	$31,051,000	+27.7%	6,915,525	+3.2%	3.24%	+0.5%
SNSS	Buy	SUNESIS PHARMACEUTICALS INC	$24,152,000	-1.2%	4,869,261	+3.2%	2.52%	-22.3%
KERX	Sell	KERYX BIOPHARMACEUTICALS INC	$24,128,000	-42.9%	2,391,261	-57.7%	2.52%	-55.1%
CCXI	New	CHEMOCENTRYX INC	$16,932,000	–	3,045,380	–	1.77%	–
ACHN	Buy	ACHILLION PHARMACEUTICALS INcall	$16,610,000	+1.5%	5,500,000	+175.0%	1.73%	-20.1%
BLUE	New	BLUEBIRD BIO INC	$12,602,000	–	467,418	–	1.32%	–
RMTI	New	ROCKWELL MED INCput	$11,400,000	–	1,000,000	–	1.19%	–
MYGN	New	MYRIAD GENETICS INC	$10,575,000	–	450,000	–	1.10%	–
OMER	Sell	OMEROS CORP	$10,289,000	-30.9%	1,055,311	-64.3%	1.07%	-45.6%
AMPE	New	AMPIO PHARMACEUTICALS INC	$9,942,000	–	1,325,566	–	1.04%	–
NLNK	New	NEWLINK GENETICS CORPcall	$9,390,000	–	500,000	–	0.98%	–
MRTX	New	MIRATI THERAPEUTICS INC	$8,359,000	–	551,723	–	0.87%	–
OGXI	Sell	ONCOGENEX PHARMACEUTICALS IN	$7,076,000	-16.4%	763,332	-11.6%	0.74%	-34.1%
CNDO	New	CORONADO BIOSCIENCES INCcall	$7,011,000	–	1,000,000	–	0.73%	–
PTCT	New	PTC THERAPEUTICS INC	$6,438,000	–	300,000	–	0.67%	–
ARWR	Sell	ARROWHEAD RESH CORP	$5,005,000	-19.7%	879,561	-71.8%	0.52%	-36.8%
DYAX	New	DYAX CORPcall	$3,430,000	–	500,000	–	0.36%	–
TGTX	New	TG THERAPEUTICS INC	$3,024,000	–	600,000	–	0.32%	–
AGIO	New	AGIOS PHARMACEUTICALS INC	$1,957,000	–	70,000	–	0.20%	–
OCRX	New	OCERA THERAPEUTICS INC	$1,830,000	–	215,999	–	0.19%	–
EPZM	Sell	EPIZYME INC	$400,000	-90.6%	10,000	-93.4%	0.04%	-92.5%
TZYM	Exit	TRANZYME INC	$0	–	-2,700,000	–	-0.17%	–
SNMX	Exit	SENOMYX INC	$0	–	-975,610	–	-0.28%	–
ENTA	Exit	ENANTA PHARMACEUTICALS INC	$0	–	-436,145	–	-1.02%	–
RCPT	Exit	RECEPTOS INC	$0	–	-975,000	–	-2.57%	–

Q2 2013

			Value		Shares		↓ Weighting
ACAD	New	ACADIA PHARMACEUTICALS INC	$118,516,000	–	6,529,810	–	15.72%	–
ACAD	New	ACADIA PHARMACEUTICALS INCcall	$90,750,000	–	5,000,000	–	12.04%	–
ACHN	New	ACHILLION PHARMACEUTICALS IN	$60,984,000	–	7,455,202	–	8.09%	–
KERX	New	KERYX BIOPHARMACEUTICALS INC	$42,275,000	–	5,659,285	–	5.61%	–
SGMO	New	SANGAMO BIOSCIENCES INC	$41,925,000	–	5,368,094	–	5.56%	–
DYAX	New	DYAX CORP	$37,743,000	–	10,908,379	–	5.01%	–
NLNK	New	NEWLINK GENETICS CORP	$36,291,000	–	1,840,294	–	4.81%	–
NVAX	New	NOVAVAX INC	$35,200,000	–	17,170,801	–	4.67%	–
TXMD	New	THERAPEUTICSMD INC	$34,126,000	–	11,262,608	–	4.53%	–
INSM	New	INSMED INC	$29,102,000	–	2,433,319	–	3.86%	–
DSCI	New	DERMA SCIENCES INC	$26,632,000	–	1,994,876	–	3.53%	–
SNSS	New	SUNESIS PHARMACEUTICALS INC	$24,454,000	–	4,716,296	–	3.24%	–
XOMA	New	XOMA CORP DEL	$24,316,000	–	6,698,558	–	3.22%	–
SGMO	New	SANGAMO BIOSCIENCES INCcall	$23,430,000	–	3,000,000	–	3.11%	–
HPTX	New	HYPERION THERAPEUTICS INC	$19,863,000	–	902,858	–	2.63%	–
RCPT	New	RECEPTOS INC	$19,393,000	–	975,000	–	2.57%	–
ACHN	New	ACHILLION PHARMACEUTICALS INcall	$16,360,000	–	2,000,000	–	2.17%	–
OMER	New	OMEROS CORP	$14,883,000	–	2,953,004	–	1.97%	–
OGXI	New	ONCOGENEX PHARMACEUTICALS IN	$8,461,000	–	863,332	–	1.12%	–
ENTA	New	ENANTA PHARMACEUTICALS INC	$7,724,000	–	436,145	–	1.02%	–
KERX	New	KERYX BIOPHARMACEUTICALS INCcall	$7,470,000	–	1,000,000	–	0.99%	–
ENZ	New	ENZO BIOCHEM INC	$6,964,000	–	3,348,029	–	0.92%	–
DVAX	New	DYNAVAX TECHNOLOGIES CORP	$6,600,000	–	6,000,000	–	0.88%	–
PRTA	New	PROTHENA CORP PLC	$6,427,000	–	497,807	–	0.85%	–
ARWR	New	ARROWHEAD RESH CORP	$6,230,000	–	3,114,755	–	0.83%	–
EPZM	New	EPIZYME INC	$4,248,000	–	151,000	–	0.56%	–
SNMX	New	SENOMYX INC	$2,127,000	–	975,610	–	0.28%	–
TZYM	New	TRANZYME INC	$1,269,000	–	2,700,000	–	0.17%	–
	New	SAVIENT PHARMACEUTICALS INCnote 4.750% 2/0	$228,000	–	1,000,000	–	0.03%	–

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