| Nicholas Investment Partners, LP | 92,101 | $15,573,358 | 1.16% |
|---|
| PFM Health Sciences, LP | 138,209 | $23,369,760 | 1.10% |
|---|
| Eventide Asset Management | 339,840 | $57,463,546 | 1.03% |
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| Atika Capital Management LLC | 43,500 | $7,355,415 | 0.96% |
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| SECTORAL ASSET MANAGEMENT INC | 25,980 | $4,392,958 | 0.86% |
|---|
| VIKING GLOBAL INVESTORS LP | 1,131,263 | $191,285,261 | 0.78% |
|---|
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 101,000 | $17,078,090 | 0.74% |
|---|
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 97,377 | $16,465,477 | 0.72% |
|---|
| HighVista Strategies LLC | 9,071 | $1,533,815 | 0.71% |
|---|
| Ghost Tree Capital, LLC | 12,500 | $2,113,625 | 0.70% |
|---|
| Rhenman & Partners Asset Management AB | 35,000 | $5,918,150 | 0.64% |
|---|
| Hood River Capital Management LLC | 110,556 | $18,693,914 | 0.60% |
|---|
| CLOUGH CAPITAL PARTNERS L P | 31,930 | $5,399,044 | 0.58% |
|---|
| Values First Advisors, Inc. | 4,107 | $694,376 | 0.45% |
|---|
| Nantahala Capital Management | 30,000 | $5,072,700 | 0.43% |
|---|
| RICE HALL JAMES & ASSOCIATES, LLC | 39,381 | $6,658,933 | 0.42% |
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| KRS Capital Management, LLC | 1,914 | $323,638 | 0.34% |
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| T. Rowe Price Investment Management, Inc. | 2,742,457 | $463,723 | 0.33% |
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| MYDA Advisors LLC | 6,000 | $1,014,540 | 0.33% |
|---|
| TANG CAPITAL MANAGEMENT LLC | 10,000 | $1,690,900 | 0.24% |
|---|