| Pivotal bioVenture Partners Investment Advisor LLC | 782,008 | $169,578,435 | 55.90% |
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| Nan Fung Group Holdings Ltd | 225,688 | $48,940,443 | 31.28% |
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| Sofinnova Investments, Inc. | 1,381,149 | $299,502,161 | 19.62% |
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| Paradigm Biocapital Advisors LP | 283,605 | $61,499,744 | 4.75% |
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| First Light Asset Management, LLC | 208,746 | $45,266,570 | 3.55% |
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| Avidity Partners Management LP | 442,200 | $95,891,070 | 3.35% |
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| CATALYST PRIVATE WEALTH, LLC | 21,837 | $4,735,353 | 2.97% |
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| Rock Springs Capital Management LP | 493,527 | $107,021,330 | 2.55% |
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| Boxer Capital, LLC | 250,000 | $54,213 | 2.51% |
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| DAFNA Capital Management LLC | 42,173 | $9,145,215 | 2.50% |
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| GENERAL ATLANTIC, L.P. | 726,958 | $157,640,842 | 2.48% |
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| UNC Management Company, Inc. | 12,061 | $2,615 | 2.36% |
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| MPM BioImpact LLC | 53,399 | $11,579,573 | 2.33% |
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| Nicholas Investment Partners, LP | 155,930 | $33,813,420 | 2.31% |
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| Patient Capital Management, LLC | 176,826 | $38,344,818 | 2.13% |
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| Parkman Healthcare Partners LLC | 49,233 | $10,676,176 | 1.85% |
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| INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 25,700 | $5,566,620 | 1.70% |
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| Clarius Group, LLC | 99,221 | $21,516,074 | 1.66% |
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| Atika Capital Management LLC | 65,000 | $14,095,250 | 1.41% |
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| Eventide Asset Management | 339,968 | $73,722,061 | 1.25% |
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