| Hood River Capital Management LLC | 1,309,574 | $71,450,000 | 2.31% |
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| NEXT CENTURY GROWTH INVESTORS LLC | 366,163 | $19,977,853 | 2.20% |
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| Sio Capital Management, LLC | 70,841 | $3,865,085 | 1.91% |
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| Rhenman & Partners Asset Management AB | 271,062 | $14,748,483 | 1.62% |
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| First Light Asset Management, LLC | 309,240 | $16,872,134 | 1.52% |
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| Bellevue Group AG | 1,911,861 | $104,311,136 | 1.51% |
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| Cormorant Asset Management, LP | 322,240 | $17,581 | 1.16% |
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| SECTORAL ASSET MANAGEMENT INC | 109,950 | $5,998,872 | 1.15% |
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| Bullseye Asset Management LLC | 37,994 | $2,073 | 1.06% |
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| Granite Investment Partners, LLC | 451,073 | $24,610,543 | 1.02% |
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| RTW INVESTMENTS, LP | 884,974 | $48,284,181 | 1.00% |
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| AtonRa Partners | 10,644 | $580,737 | 0.85% |
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| OBERWEIS ASSET MANAGEMENT INC/ | 95,740 | $5,223,574 | 0.81% |
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| Magnetar Financial LLC | 732,431 | $39,961,435 | 0.78% |
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| MOODY ALDRICH PARTNERS LLC | 57,427 | $3,133,217 | 0.63% |
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| CROWN ADVISORS MANAGEMENT, INC. | 15,000 | $818 | 0.61% |
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| Champlain Investment Partners, LLC | 1,336,845 | $72,938,263 | 0.46% |
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| Lisanti Capital Growth, LLC | 58,355 | $3,183,849 | 0.44% |
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| OAK RIDGE INVESTMENTS LLC | 54,966 | $2,998,945 | 0.41% |
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| PEREGRINE CAPITAL MANAGEMENT LLC | 234,539 | $12,796,448 | 0.37% |
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