| NEXT CENTURY GROWTH INVESTORS LLC | 471,186 | $23,780,757 | 2.29% |
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| Sio Capital Management, LLC | 164,017 | $8,277,938 | 2.10% |
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| Hood River Capital Management LLC | 1,329,707 | $67,110,000 | 2.00% |
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| Bellevue Group AG | 2,223,418 | $112,215,907 | 1.60% |
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| First Light Asset Management, LLC | 312,786 | $15,786,309 | 1.24% |
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| Rhenman & Partners Asset Management AB | 230,000 | $11,608,100 | 1.22% |
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| SECTORAL ASSET MANAGEMENT INC | 127,950 | $6,457,637 | 1.08% |
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| Magnetar Financial LLC | 968,112 | $48,860,613 | 1.07% |
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| Bullseye Asset Management LLC | 41,425 | $2,091 | 1.05% |
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| BRAIDWELL LP | 573,791 | $28,959,232 | 0.95% |
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| Cormorant Asset Management, LP | 322,240 | $16,263,453 | 0.91% |
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| Granite Investment Partners, LLC | 447,088 | $22,564,531 | 0.90% |
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| RTW INVESTMENTS, LP | 884,974 | $44,664,638 | 0.85% |
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| Intrinsic Edge Capital Management LLC | 212,154 | $10,707,412 | 0.77% |
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| OBERWEIS ASSET MANAGEMENT INC/ | 125,440 | $6,330,957 | 0.77% |
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| AtonRa Partners | 9,134 | $460,993 | 0.71% |
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| Avidity Partners Management LP | 379,700 | $19,163,459 | 0.67% |
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| Champlain Investment Partners, LLC | 1,741,395 | $87,888,206 | 0.54% |
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| CROWN ADVISORS MANAGEMENT, INC. | 15,000 | $757 | 0.49% |
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| OAK RIDGE INVESTMENTS LLC | 53,230 | $2,686,518 | 0.33% |
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