| NEXT CENTURY GROWTH INVESTORS LLC | 513,956 | $28,843,210 | 3.14% |
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| Hood River Capital Management LLC | 1,353,100 | $75,935,972 | 2.44% |
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| Bellevue Group AG | 2,252,851 | $126,429,998 | 2.04% |
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| SECTORAL ASSET MANAGEMENT INC | 172,950 | $9,705,954 | 1.89% |
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| First Light Asset Management, LLC | 321,173 | $18,024,229 | 1.71% |
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| Rhenman & Partners Asset Management AB | 230,000 | $12,907,600 | 1.39% |
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| Bullseye Asset Management LLC | 41,425 | $2,325 | 1.30% |
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| Intrinsic Edge Capital Management LLC | 191,354 | $10,738,786 | 1.21% |
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| AtonRa Partners | 8,833 | $495,708 | 1.04% |
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| OBERWEIS ASSET MANAGEMENT INC/ | 161,620 | $9,070,114 | 0.96% |
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| Magnetar Financial LLC | 627,693 | $35,226,131 | 0.90% |
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| Cormorant Asset Management, LP | 250,000 | $14,030,000 | 0.82% |
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| Granite Investment Partners, LLC | 328,666 | $18,444,736 | 0.77% |
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| Champlain Investment Partners, LLC | 2,013,401 | $112,992,064 | 0.73% |
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| Lisanti Capital Growth, LLC | 75,550 | $4,239,866 | 0.67% |
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| BRAIDWELL LP | 354,527 | $19,896,055 | 0.63% |
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| CROWN ADVISORS MANAGEMENT, INC. | 15,000 | $841 | 0.60% |
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| KENNEDY CAPITAL MANAGEMENT LLC | 399,970 | $22,446,316 | 0.55% |
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| RTW INVESTMENTS, LP | 442,487 | $24,832,370 | 0.52% |
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| Richmond Brothers, Inc. | 4,749 | $266,514 | 0.50% |
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