$441 Million is the total value of Ikarian Capital, LLC's 117 reported holdings in Q1 2023. The portfolio turnover from Q4 2022 to Q1 2023 was 91.8% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| SRPT | New | SAREPTA THERAPEUTICS INCput | $37,393,279 | – | 271,300 | +100.0% | 8.48% | – |
| SRPT | New | SAREPTA THERAPEUTICS INCcall | $28,310,282 | – | 205,400 | +100.0% | 6.42% | – |
| ITCI | New | INTRA-CELLULAR THERAPIES INCcall | $20,577,000 | – | 380,000 | +100.0% | 4.67% | – |
| RXDX | Sell | PROMETHEUS BIOSCIENCES INC | $13,514,378 | -57.5% | 125,926 | -56.4% | 3.07% | -60.0% |
| IMVT | Sell | IMMUNOVANT INC | $12,010,913 | -30.0% | 774,398 | -19.9% | 2.72% | -34.2% |
| Buy | ASTRIA THERAPEUTICS INC | $11,562,887 | +15.0% | 869,390 | +28.8% | 2.62% | +8.2% | |
| MRK | New | MERCK & CO INC | $10,639,000 | – | 100,000 | +100.0% | 2.41% | – |
| BBIO | New | BRIDGEBIO PHARMA INC | $9,859,894 | – | 594,686 | +100.0% | 2.24% | – |
| AXSM | New | AXSOME THERAPEUTICS INCcall | $9,252,000 | – | 150,000 | +100.0% | 2.10% | – |
| AXSM | New | AXSOME THERAPEUTICS INCput | $9,252,000 | – | 150,000 | +100.0% | 2.10% | – |
| BBIO | New | BRIDGEBIO PHARMA INCcall | $9,112,368 | – | 549,600 | +100.0% | 2.07% | – |
| RETA | New | REATA PHARMACEUTICALS INCcall | $9,092,000 | – | 100,000 | +100.0% | 2.06% | – |
| BMEA | New | BIOMEA FUSION INCcall | $9,023,910 | – | 291,000 | +100.0% | 2.05% | – |
| TERN | Sell | TERNS PHARMACEUTICALS INC | $8,540,677 | +13.8% | 721,341 | -2.2% | 1.94% | +7.0% |
| PCVX | Sell | VAXCYTE INC | $8,433,000 | -29.7% | 225,000 | -10.0% | 1.91% | -33.9% |
| INSM | New | INSMED INC | $8,269,250 | – | 485,000 | +100.0% | 1.88% | – |
| MORF | New | MORPHIC HLDG INCcall | $8,032,376 | – | 213,400 | +100.0% | 1.82% | – |
| XBI | SPDR SER TRput | $7,621,000 | -8.2% | 100,000 | 0.0% | 1.73% | -13.6% | |
| RETA | New | REATA PHARMACEUTICALS INCcl a | $7,324,879 | – | 80,564 | +100.0% | 1.66% | – |
| APLS | New | APELLIS PHARMACEUTICALS INC | $6,595,999 | – | 100,000 | +100.0% | 1.50% | – |
| KDNY | CHINOOK THERAPEUTICS INC | $6,562,191 | – | 283,464 | 0.0% | 1.49% | – | |
| BMEA | New | BIOMEA FUSION INC | $6,542,334 | – | 210,975 | +100.0% | 1.48% | – |
| BLU | BELLUS HEALTH INC NEW | $6,374,405 | -12.4% | 885,334 | 0.0% | 1.45% | -17.7% | |
| ACRS | New | ACLARIS THERAPEUTICS INCput | $5,921,880 | – | 732,000 | +100.0% | 1.34% | – |
| XENE | XENON PHARMACEUTICALS INC | $5,743,793 | -9.2% | 160,486 | 0.0% | 1.30% | -14.7% | |
| Sell | BIOHAVEN LTD | $5,495,774 | -52.7% | 402,326 | -52.0% | 1.25% | -55.5% | |
| TCON | TRACON PHARMACEUTICALS INC | $5,226,851 | +26.8% | 2,765,530 | 0.0% | 1.19% | +19.3% | |
| ISEE | Sell | IVERIC BIO INC | $5,194,967 | -35.6% | 213,521 | -43.4% | 1.18% | -39.4% |
| PTGX | New | PROTAGONIST THERAPEUTICS INCcall | $4,862,200 | – | 211,400 | +100.0% | 1.10% | – |
| PTGX | New | PROTAGONIST THERAPEUTICS INCput | $4,862,200 | – | 211,400 | +100.0% | 1.10% | – |
| BMRN | New | BIOMARIN PHARMACEUTICAL INC | $4,862,000 | – | 50,000 | +100.0% | 1.10% | – |
| ACRS | New | ACLARIS THERAPEUTICS INCcall | $4,767,437 | – | 589,300 | +100.0% | 1.08% | – |
| VRNA | Sell | VERONA PHARMA PLCsponsored ads | $4,591,834 | -31.1% | 228,677 | -10.4% | 1.04% | -35.2% |
| ALT | New | ALTIMMUNE INCput | $4,545,784 | – | 1,077,200 | +100.0% | 1.03% | – |
| BCYC | New | BICYCLE THERAPEUTICS PLCsponsored ads | $4,405,273 | – | 207,112 | +100.0% | 1.00% | – |
| New | AMYLYX PHARMACEUTICALS INCcall | $4,401,000 | – | 150,000 | +100.0% | 1.00% | – | |
| BCYC | New | BICYCLE THERAPEUTICS PLCcall | $4,254,000 | – | 200,000 | +100.0% | 0.96% | – |
| New | ROIVANT SCIENCES LTD | $4,243,500 | – | 575,000 | +100.0% | 0.96% | – | |
| RCUS | Buy | ARCUS BIOSCIENCES INC | $4,195,200 | +47.0% | 230,000 | +66.7% | 0.95% | +38.4% |
| CLDX | New | CELLDEX THERAPEUTICS INC NEWput | $3,957,800 | – | 110,000 | +100.0% | 0.90% | – |
| AVTE | Buy | AEROVATE THERAPEUTICS INC | $3,936,094 | +5.0% | 195,146 | +52.6% | 0.89% | -1.2% |
| MRUS | Buy | MERUS N V | $3,839,161 | +59.1% | 208,650 | +33.8% | 0.87% | +49.7% |
| CLDX | Sell | CELLDEX THERAPEUTICS INC NEW | $3,815,932 | -68.0% | 106,057 | -60.3% | 0.87% | -69.9% |
| ALT | Buy | ALTIMMUNE INCcall | $3,792,092 | -60.1% | 898,600 | +55.6% | 0.86% | -62.5% |
| XLV | New | SELECT SECTOR SPDR TRsbi healthcare | $3,556,137 | – | 27,469 | +100.0% | 0.81% | – |
| INSM | New | INSMED INCcall | $3,410,000 | – | 200,000 | +100.0% | 0.77% | – |
| ALT | Buy | ALTIMMUNE INC | $2,858,206 | -36.5% | 677,300 | +147.7% | 0.65% | -40.2% |
| BIVI | New | BIOVIE INCcl a new | $2,816,332 | – | 348,556 | +100.0% | 0.64% | – |
| ARDX | Sell | ARDELYX INC | $2,772,572 | -29.4% | 578,825 | -58.0% | 0.63% | -33.6% |
| DCPH | Sell | DECIPHERA PHARMACEUTICALS IN | $2,696,179 | -55.2% | 174,510 | -52.5% | 0.61% | -57.9% |
| KZR | Buy | KEZAR LIFE SCIENCES INC | $2,634,195 | -40.6% | 841,596 | +33.6% | 0.60% | -44.1% |
| IMVT | Buy | IMMUNOVANT INCcall | $2,486,253 | +434.6% | 160,300 | +511.8% | 0.56% | +403.6% |
| BTAI | Sell | BIOXCEL THERAPEUTICS INC | $2,482,041 | -53.8% | 133,014 | -46.8% | 0.56% | -56.6% |
| ACRS | New | ACLARIS THERAPEUTICS INC | $2,428,319 | – | 300,163 | +100.0% | 0.55% | – |
| New | VENTYX BIOSCIENCES INC | $2,177,501 | – | 65,000 | +100.0% | 0.49% | – | |
| ESPR | Sell | ESPERION THERAPEUTICS INC NE | $2,155,411 | -81.7% | 1,355,605 | -28.3% | 0.49% | -82.8% |
| New | JASPER THERAPEUTICS INC | $2,038,579 | – | 1,126,287 | +100.0% | 0.46% | – | |
| CYTK | New | CYTOKINETICS INC | $1,958,886 | – | 55,666 | +100.0% | 0.44% | – |
| AKRO | New | AKERO THERAPEUTICS INC | $1,913,000 | – | 50,000 | +100.0% | 0.43% | – |
| MIST | MILESTONE PHARMACEUTICALS IN | $1,814,039 | -0.5% | 460,416 | 0.0% | 0.41% | -6.4% | |
| MGNX | New | MACROGENICS INC | $1,792,500 | – | 250,000 | +100.0% | 0.41% | – |
| MORF | New | MORPHIC HLDG INC | $1,726,660 | – | 45,873 | +100.0% | 0.39% | – |
| ARKG | ARK ETF TRgenomic rev etf | $1,397,112 | +6.5% | 46,462 | 0.0% | 0.32% | +0.3% | |
| New | CORBUS PHARMACEUTICALS HLDGS | $1,397,730 | – | 192,260 | +100.0% | 0.32% | – | |
| BTAI | New | BIOXCEL THERAPEUTICS INCcall | $1,328,592 | – | 71,200 | +100.0% | 0.30% | – |
| BLUE | Sell | BLUEBIRD BIO INC | $1,312,157 | -76.7% | 412,628 | -49.2% | 0.30% | -78.0% |
| BMEA | New | BIOMEA FUSION INCput | $1,240,400 | – | 40,000 | +100.0% | 0.28% | – |
| MRTX | Sell | MIRATI THERAPEUTICS INC | $1,230,658 | -74.9% | 33,100 | -69.4% | 0.28% | -76.4% |
| KPTI | New | KARYOPHARM THERAPEUTICS INC | $1,167,000 | – | 300,000 | +100.0% | 0.26% | – |
| ICPT | INTERCEPT PHARMACEUTICALS IN | $1,144,236 | +8.6% | 85,200 | 0.0% | 0.26% | +2.4% | |
| SRPT | Sell | SAREPTA THERAPEUTICS INC | $1,147,297 | -68.7% | 8,324 | -70.6% | 0.26% | -70.6% |
| ACAD | Sell | ACADIA PHARMACEUTICALS INC | $1,129,200 | -78.2% | 60,000 | -81.5% | 0.26% | -79.5% |
| KALV | New | KALVISTA PHARMACEUTICALS INC | $1,100,400 | – | 140,000 | +100.0% | 0.25% | – |
| DCTH | New | DELCATH SYS INC | $1,078,601 | – | 360,569 | +100.0% | 0.24% | – |
| OCUL | OCULAR THERAPEUTIX INC | $1,054,000 | +87.5% | 200,000 | 0.0% | 0.24% | +75.7% | |
| ABOS | ACUMEN PHARMACEUTICALS INC | $1,035,077 | -24.8% | 254,945 | 0.0% | 0.24% | -29.2% | |
| PNT | POINT BIOPHARMA GLOBAL INC | $1,014,639 | -0.3% | 139,565 | 0.0% | 0.23% | -6.1% | |
| KOD | New | KODIAK SCIENCES INC | $1,007,668 | – | 162,527 | +100.0% | 0.23% | – |
| PRQR | Buy | PROQR THRAPEUTICS N V | $1,006,691 | -35.6% | 472,625 | +11.8% | 0.23% | -39.5% |
| IVA | New | INVENTIVA SAads | $999,202 | – | 292,599 | +100.0% | 0.23% | – |
| New | ACHIEVE LIFE SCIENCES INC | $989,535 | – | 174,714 | +100.0% | 0.22% | – | |
| IMUX | IMMUNIC INC | $968,500 | +6.4% | 650,000 | 0.0% | 0.22% | 0.0% | |
| RPHM | RENEO PHARMACEUTICALS INC | $931,798 | +156.7% | 155,819 | 0.0% | 0.21% | +139.8% | |
| KRYS | Sell | KRYSTAL BIOTECH INCput | $824,618 | -93.7% | 10,300 | -93.8% | 0.19% | -94.1% |
| New | TYRA BIOSCIENCES INC | $774,092 | – | 48,170 | +100.0% | 0.18% | – | |
| SAGE | Sell | SAGE THERAPEUTICS INC | $747,098 | -71.1% | 17,805 | -73.7% | 0.17% | -72.8% |
| VKTX | Sell | VIKING THERAPEUTICS INC | $718,548 | -62.4% | 43,156 | -78.8% | 0.16% | -64.6% |
| LYRA | LYRA THERAPEUTICS INC | $711,427 | -34.1% | 343,685 | 0.0% | 0.16% | -38.1% | |
| COGT | COGENT BIOSCIENCES INC | $677,246 | -6.7% | 62,766 | 0.0% | 0.15% | -12.0% | |
| BCLI | BRAINSTORM CELL THERAPEUTICS | $626,786 | +101.2% | 189,935 | 0.0% | 0.14% | +89.3% | |
| New | BIOHAVEN LTDcall | $617,432 | – | 45,200 | +100.0% | 0.14% | – | |
| TARA | PROTARA THERAPEUTICS INC | $584,859 | +15.7% | 188,664 | 0.0% | 0.13% | +9.0% | |
| ELDN | ELEDON PHARMACEUTICALS INC | $523,518 | +1.7% | 221,830 | 0.0% | 0.12% | -4.0% | |
| IMTX | Buy | IMMATICS N.V | $526,266 | +23.2% | 179,552 | +266.2% | 0.12% | +15.5% |
| AUTL | AUTOLUS THERAPEUTICS PLCspon ads | $478,559 | -3.2% | 260,087 | 0.0% | 0.11% | -8.4% | |
| PTCT | New | PTC THERAPEUTICS INCcall | $474,712 | – | 9,800 | +100.0% | 0.11% | – |
| New | ASLAN PHARMACEUTICALS LTDspon ads new | $475,856 | – | 164,088 | +100.0% | 0.11% | – | |
| ANEB | ANEBULO PHARMACEUTICALS INC | $462,360 | +23.3% | 156,203 | 0.0% | 0.10% | +16.7% | |
| IMGN | New | IMMUNOGEN INCcall | $409,344 | – | 106,600 | +100.0% | 0.09% | – |
| CMMB | Sell | CHEMOMAB THERAPEUTICS LTDsponsored ads | $342,091 | -65.9% | 236,709 | -24.5% | 0.08% | -67.8% |
| XFOR | X4 PHARMACEUTICALS INC | $303,745 | -12.4% | 349,133 | 0.0% | 0.07% | -17.9% | |
| New | AMYLYX PHARMACEUTICALS INC | $293,400 | – | 10,000 | +100.0% | 0.07% | – | |
| BIIB | BIOGEN INC | $267,465 | +0.4% | 962 | 0.0% | 0.06% | -4.7% | |
| ERYP | Buy | ERYTECH PHARMAsponsored adr | $252,111 | +21175.2% | 248,426 | +8128.8% | 0.06% | – |
| CNTB | CONNECT BIOPHARMA HLDGS LTDads | $219,479 | +15.2% | 219,501 | 0.0% | 0.05% | +8.7% | |
| SYBX | SYNLOGIC INC | $193,871 | -16.8% | 306,757 | 0.0% | 0.04% | -21.4% | |
| ARKK | ARK ETF TRinnovation etf | $182,297 | +29.1% | 4,519 | 0.0% | 0.04% | +20.6% | |
| BELLICUM PHARMACEUTICALS INC | $147,873 | -54.2% | 448,101 | 0.0% | 0.03% | -56.4% | ||
| RLMD | RELMADA THERAPEUTICS INC | $148,010 | -35.2% | 65,491 | 0.0% | 0.03% | -38.2% | |
| GNFT | New | GENFIT S Aads | $131,511 | – | 32,786 | +100.0% | 0.03% | – |
| SPPI | SPECTRUM PHARMACEUTICALS INC | $132,735 | +103.5% | 176,980 | 0.0% | 0.03% | +87.5% | |
| STSA | SATSUMA PHARMACEUTICALS INC | $95,037 | -22.4% | 136,059 | 0.0% | 0.02% | -26.7% | |
| FNCH | FINCH THERAPEUTICS GROUP INC | $93,359 | -18.1% | 237,553 | 0.0% | 0.02% | -25.0% | |
| New | ROCKET PHARMACEUTICALS INC*w exp 09/02/202 | $59,985 | – | 367,112 | +100.0% | 0.01% | – | |
| MDGL | MADRIGAL PHARMACEUTICALS INC | $18,170 | -16.5% | 75 | 0.0% | 0.00% | -20.0% | |
| GOSS | GOSSAMER BIO INC | $7,686 | -41.9% | 6,100 | 0.0% | 0.00% | -33.3% | |
| CYCC | New | CYCLACEL PHARMACEUTICALS INC | $10,999 | – | 275,000 | +100.0% | 0.00% | – |
| DSGN | Exit | DESIGN THERAPEUTICS INCcall | $0 | – | -800 | -100.0% | -0.00% | – |
| TCDA | Exit | TRICIDA INCcall | $0 | – | -145,700 | -100.0% | -0.01% | – |
| CRBP | Exit | CORBUS PHARMACEUTICALS HLDGS | $0 | – | -397,168 | -100.0% | -0.01% | – |
| DSGN | Exit | DESIGN THERAPEUTICS INC | $0 | – | -11,568 | -100.0% | -0.03% | – |
| ASLN | Exit | ASLAN PHARMACEUTICALS LTDads | $0 | – | -820,455 | -100.0% | -0.04% | – |
| CABA | Exit | CABALETTA BIO INC | $0 | – | -30,286 | -100.0% | -0.07% | – |
| PRAX | Exit | PRAXIS PRECISION MEDICINES I | $0 | – | -150,000 | -100.0% | -0.09% | – |
| GERN | Exit | GERON CORPput | $0 | – | -150,000 | -100.0% | -0.09% | – |
| BIIB | Exit | BIOGEN INCcall | $0 | – | -1,800 | -100.0% | -0.12% | – |
| DSGN | Exit | DESIGN THERAPEUTICS INCput | $0 | – | -48,500 | -100.0% | -0.12% | – |
| GERN | Exit | GERON CORPcall | $0 | – | -650,000 | -100.0% | -0.38% | – |
| Exit | ASTRIA THERAPEUTICS INCcall | $0 | – | -171,100 | -100.0% | -0.62% | – | |
| SGEN | Exit | SEAGEN INC | $0 | – | -25,000 | -100.0% | -0.78% | – |
| ARVN | Exit | ARVINAS INCcall | $0 | – | -100,000 | -100.0% | -0.82% | – |
| VRNA | Exit | VERONA PHARMA PLCcall | $0 | – | -200,000 | -100.0% | -1.26% | – |
| ETNB | Exit | 89BIO INC | $0 | – | -454,000 | -100.0% | -1.39% | – |
| RCUS | Exit | ARCUS BIOSCIENCES INCput | $0 | – | -283,100 | -100.0% | -1.41% | – |
| RETA | Exit | REATA PHARMACEUTICALS INCput | $0 | – | -201,200 | -100.0% | -1.84% | – |
| ESPR | Exit | ESPERION THERAPEUTICS INC NEcall | $0 | – | -1,296,900 | -100.0% | -1.95% | – |
| XBI | Exit | SPDR SER TRcall | $0 | – | -100,000 | -100.0% | -2.00% | – |
| HZNP | Exit | HORIZON THERAPEUTICS PUB L | $0 | – | -89,219 | -100.0% | -2.45% | – |
| RXDX | Exit | PROMETHEUS BIOSCIENCES INCcall | $0 | – | -100,000 | -100.0% | -2.65% | – |
| MDGL | Exit | MADRIGAL PHARMACEUTICALS INCput | $0 | – | -300,000 | -100.0% | -21.01% | – |
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2023-05-15
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| XENON PHARMACEUTICALS INC | 15 | Q2 2023 | 1.5% |
| OCULAR THERAPEUTIX INC | 15 | Q3 2023 | 1.4% |
| SAREPTA THERAPEUTICS INC | 14 | Q3 2023 | 6.4% |
| X4 PHARMACEUTICALS INC - PIPE | 14 | Q2 2023 | 1.4% |
| PROTARA THERAPEUTICS INC | 14 | Q3 2023 | 1.2% |
| SPDR SER TR | 13 | Q3 2023 | 9.0% |
| VAXCYTE INC | 13 | Q3 2023 | 2.9% |
| TRACON PHARMACEUTICALS INC | 13 | Q3 2023 | 1.4% |
| MILESTONE PHARMACEUTICALS IN | 13 | Q3 2023 | 1.7% |
| BELLUS HEALTH INC NEW | 13 | Q1 2023 | 1.8% |
View Ikarian Capital, LLC's complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Milestone Pharmaceuticals Inc. | February 14, 2023 | 460,416 | 1.3% |
| X4 Pharmaceuticals, Inc | February 14, 2023 | 349,133 | 0.3% |
| aTYR PHARMA INC | February 14, 2022 | 35,048 | 0.1% |
| Cyclacel Pharmaceuticals, Inc. | February 14, 2022 | 99,422 | 1.0% |
| KalVista Pharmaceuticals, Inc. | February 14, 2022 | 36,576 | 0.2% |
| Lyra Therapeutics, Inc. | February 14, 2022 | 394,536 | 3.0% |
| Odonate Therapeutics, Inc. | February 14, 2022 | 1,340,631 | 3.5% |
| Protara Therapeutics, Inc. | February 14, 2022 | 279,256 | 2.5% |
| Science 37 Holdings, Inc.Sold out | February 14, 2022 | 0 | 0.0% |
| scPharmaceuticals Inc. | February 14, 2022 | 901,362 | 3.3% |
View Ikarian Capital, LLC's complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| SC 13G/A | 2024-04-05 |
| 13F-HR | 2024-02-14 |
| SC 13G/A | 2024-02-14 |
| 13F-HR | 2023-11-14 |
| 13F-HR | 2023-08-14 |
| 13F-HR | 2023-05-15 |
| SC 13G/A | 2023-02-14 |
| SC 13G/A | 2023-02-14 |
| SC 13G/A | 2023-02-14 |
| SC 13G/A | 2023-02-14 |
View Ikarian Capital, LLC's complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.