$415 Million is the total value of Ikarian Capital, LLC's 86 reported holdings in Q4 2022. The portfolio turnover from Q3 2022 to Q4 2022 was 59.2% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| MDGL | New | MADRIGAL PHARMACEUTICALS INCput | $87,075,000 | – | 300,000 | +100.0% | 21.01% | – |
| RXDX | Buy | PROMETHEUS BIOSCIENCES INC | $31,781,860 | +133.0% | 288,926 | +25.0% | 7.67% | +182.1% |
| IMVT | Buy | IMMUNOVANT INC | $17,158,925 | +278.9% | 966,700 | +19.1% | 4.14% | +359.0% |
| KRYS | Buy | KRYSTAL BIOTECH INCput | $13,142,598 | +98.1% | 165,900 | +74.3% | 3.17% | +139.9% |
| PCVX | New | VAXCYTE INC | $11,987,501 | – | 250,000 | +100.0% | 2.89% | – |
| CLDX | Sell | CELLDEX THERAPEUTICS INC NEW | $11,921,406 | +33.6% | 267,476 | -15.7% | 2.88% | +61.8% |
| ESPR | Sell | ESPERION THERAPEUTICS INC NE | $11,781,846 | -17.5% | 1,891,147 | -11.3% | 2.84% | -0.1% |
| New | BIOHAVEN LTD | $11,624,500 | – | 837,500 | +100.0% | 2.80% | – | |
| RXDX | Sell | PROMETHEUS BIOSCIENCES INCcall | $11,000,000 | +4.7% | 100,000 | -43.8% | 2.65% | +26.8% |
| HZNP | Buy | HORIZON THERAPEUTICS PUB L | $10,153,123 | +121.1% | 89,219 | +20.2% | 2.45% | +167.7% |
| Sell | ASTRIA THERAPEUTICS INC | $10,053,370 | +59.0% | 675,176 | -3.5% | 2.42% | +92.5% | |
| ALT | Sell | ALTIMMUNE INCcall | $9,498,230 | -11.7% | 577,400 | -31.5% | 2.29% | +6.8% |
| XBI | New | SPDR SER TRcall | $8,300,000 | – | 100,000 | +100.0% | 2.00% | – |
| XBI | Sell | SPDR SER TRput | $8,300,000 | -30.2% | 100,000 | -33.3% | 2.00% | -15.6% |
| ESPR | Buy | ESPERION THERAPEUTICS INC NEcall | $8,079,687 | +503.4% | 1,296,900 | +548.4% | 1.95% | +630.0% |
| ISEE | Sell | IVERIC BIO INC | $8,072,019 | -54.0% | 377,021 | -61.5% | 1.95% | -44.4% |
| RETA | Buy | REATA PHARMACEUTICALS INCput | $7,643,588 | +1550.9% | 201,200 | +993.5% | 1.84% | +1904.3% |
| TERN | Sell | TERNS PHARMACEUTICALS INC | $7,505,908 | +40.9% | 737,319 | -18.4% | 1.81% | +70.7% |
| BLU | Buy | BELLUS HEALTH INC NEW | $7,277,445 | -18.9% | 885,334 | +4.1% | 1.76% | -1.8% |
| VRNA | Sell | VERONA PHARMA PLCsponsored ads | $6,666,573 | +3354.2% | 255,131 | -19.0% | 1.61% | +4131.6% |
| XENE | XENON PHARMACEUTICALS INC | $6,327,963 | +9.2% | 160,486 | 0.0% | 1.53% | +32.2% | |
| DCPH | Sell | DECIPHERA PHARMACEUTICALS IN | $6,017,081 | -33.9% | 367,119 | -25.4% | 1.45% | -20.0% |
| RCUS | New | ARCUS BIOSCIENCES INCput | $5,854,508 | – | 283,100 | +100.0% | 1.41% | – |
| ETNB | Buy | 89BIO INC | $5,779,419 | +399.1% | 454,000 | +127.0% | 1.39% | +503.5% |
| BLUE | Buy | BLUEBIRD BIO INC | $5,623,385 | +92.1% | 812,628 | +75.7% | 1.36% | +132.8% |
| BTAI | New | BIOXCEL THERAPEUTICS INC | $5,370,000 | – | 250,000 | +100.0% | 1.30% | – |
| VRNA | New | VERONA PHARMA PLCcall | $5,226,000 | – | 200,000 | +100.0% | 1.26% | – |
| ACAD | ACADIA PHARMACEUTICALS INC | $5,174,001 | -2.7% | 325,000 | 0.0% | 1.25% | +17.7% | |
| MRTX | New | MIRATI THERAPEUTICS INC | $4,898,010 | – | 108,100 | +100.0% | 1.18% | – |
| ALT | Sell | ALTIMMUNE INC | $4,497,956 | -25.4% | 273,432 | -42.1% | 1.08% | -9.7% |
| KZR | Sell | KEZAR LIFE SCIENCES INC | $4,435,102 | -29.3% | 629,986 | -13.5% | 1.07% | -14.4% |
| TCON | TRACON PHARMACEUTICALS INC | $4,120,639 | -10.8% | 2,765,530 | 0.0% | 0.99% | +8.0% | |
| ARDX | Sell | ARDELYX INC | $3,929,651 | +3.8% | 1,378,825 | -56.6% | 0.95% | +25.7% |
| AVTE | Sell | AEROVATE THERAPEUTICS INC | $3,748,085 | +13.0% | 127,921 | -36.0% | 0.90% | +36.8% |
| SRPT | Buy | SAREPTA THERAPEUTICS INC | $3,670,224 | +97.5% | 28,324 | +68.5% | 0.88% | +139.2% |
| ARVN | ARVINAS INCcall | $3,421,000 | -23.1% | 100,000 | 0.0% | 0.82% | -7.0% | |
| SGEN | New | SEAGEN INC | $3,212,750 | – | 25,000 | +100.0% | 0.78% | – |
| RCUS | New | ARCUS BIOSCIENCES INC | $2,853,572 | – | 137,987 | +100.0% | 0.69% | – |
| SAGE | Sell | SAGE THERAPEUTICS INC | $2,586,083 | -58.2% | 67,805 | -57.0% | 0.62% | -49.3% |
| New | ASTRIA THERAPEUTICS INCcall | $2,547,679 | – | 171,100 | +100.0% | 0.62% | – | |
| MRUS | New | MERUS N V | $2,413,320 | – | 156,000 | +100.0% | 0.58% | – |
| VKTX | Sell | VIKING THERAPEUTICS INC | $1,909,666 | +51.6% | 203,156 | -56.1% | 0.46% | +83.7% |
| MIST | Sell | MILESTONE PHARMACEUTICALS IN | $1,823,248 | -76.8% | 460,416 | -46.2% | 0.44% | -71.9% |
| GERN | Buy | GERON CORPcall | $1,573,000 | +34.4% | 650,000 | +30.0% | 0.38% | +62.7% |
| PRQR | New | PROQR THRAPEUTICS N V | $1,563,713 | – | 422,625 | +100.0% | 0.38% | – |
| ABOS | Sell | ACUMEN PHARMACEUTICALS INC | $1,376,703 | -60.8% | 254,945 | -27.2% | 0.33% | -52.6% |
| ARKG | Sell | ARK ETF TRgenomic rev etf | $1,311,622 | -58.6% | 46,462 | -51.8% | 0.32% | -50.0% |
| LYRA | LYRA THERAPEUTICS INC | $1,079,171 | -37.3% | 343,685 | 0.0% | 0.26% | -24.2% | |
| ICPT | INTERCEPT PHARMACEUTICALS IN | $1,053,924 | -11.4% | 85,200 | 0.0% | 0.25% | +7.2% | |
| PNT | Sell | POINT BIOPHARMA GLOBAL INC | $1,017,429 | -70.8% | 139,565 | -69.0% | 0.24% | -64.7% |
| CMMB | Buy | CHEMOMAB THERAPEUTICS LTDsponsored ads | $1,002,855 | +63.9% | 313,392 | +27.4% | 0.24% | +98.4% |
| IMUX | New | IMMUNIC INC | $910,000 | – | 650,000 | +100.0% | 0.22% | – |
| COGT | Sell | COGENT BIOSCIENCES INC | $725,576 | -70.1% | 62,766 | -61.4% | 0.18% | -63.8% |
| OCUL | Sell | OCULAR THERAPEUTIX INC | $562,000 | -48.9% | 200,000 | -24.5% | 0.14% | -37.9% |
| ELDN | ELEDON PHARMACEUTICALS INC | $514,645 | -15.9% | 221,830 | 0.0% | 0.12% | +1.6% | |
| TARA | PROTARA THERAPEUTICS INC | $505,619 | -9.4% | 188,664 | 0.0% | 0.12% | +9.9% | |
| BIIB | Sell | BIOGEN INCcall | $498,456 | -97.4% | 1,800 | -97.4% | 0.12% | -96.8% |
| DSGN | DESIGN THERAPEUTICS INCput | $497,610 | -38.6% | 48,500 | 0.0% | 0.12% | -25.9% | |
| AUTL | AUTOLUS THERAPEUTICS PLCspon ads | $494,166 | -11.1% | 260,087 | 0.0% | 0.12% | +7.2% | |
| IMVT | New | IMMUNOVANT INCcall | $465,050 | – | 26,200 | +100.0% | 0.11% | – |
| IMTX | IMMATICS N.V | $427,060 | -12.8% | 49,031 | 0.0% | 0.10% | +5.1% | |
| ANEB | ANEBULO PHARMACEUTICALS INC | $374,888 | -14.2% | 156,203 | 0.0% | 0.09% | +3.4% | |
| GERN | New | GERON CORPput | $363,000 | – | 150,000 | +100.0% | 0.09% | – |
| RPHM | RENEO PHARMACEUTICALS INC | $363,059 | -30.3% | 155,819 | 0.0% | 0.09% | -15.4% | |
| PRAX | New | PRAXIS PRECISION MEDICINES I | $357,000 | – | 150,000 | +100.0% | 0.09% | – |
| XFOR | Sell | X4 PHARMACEUTICALS INC | $346,689 | -64.4% | 349,133 | -38.6% | 0.08% | -56.7% |
| BELLICUM PHARMACEUTICALS INC | $322,633 | -39.9% | 448,101 | 0.0% | 0.08% | -27.1% | ||
| BCLI | BRAINSTORM CELL THERAPEUTICS | $311,494 | -62.9% | 189,935 | 0.0% | 0.08% | -55.1% | |
| CABA | Sell | CABALETTA BIO INC | $280,145 | +157.0% | 30,286 | -82.0% | 0.07% | +209.1% |
| BIIB | Sell | BIOGEN INC | $266,398 | -90.9% | 962 | -91.2% | 0.06% | -89.0% |
| SYBX | SYNLOGIC INC | $233,135 | -20.2% | 306,757 | 0.0% | 0.06% | -3.4% | |
| RLMD | New | RELMADA THERAPEUTICS INC | $228,563 | – | 65,491 | +100.0% | 0.06% | – |
| CNTB | CONNECT BIOPHARMA HLDGS LTDads | $190,482 | -32.7% | 219,501 | 0.0% | 0.05% | -17.9% | |
| ASLN | ASLAN PHARMACEUTICALS LTDads | $151,446 | +3.7% | 820,455 | 0.0% | 0.04% | +27.6% | |
| ARKK | ARK ETF TRinnovation etf | $141,174 | -17.4% | 4,519 | 0.0% | 0.03% | 0.0% | |
| STSA | SATSUMA PHARMACEUTICALS INC | $122,453 | -85.0% | 136,059 | 0.0% | 0.03% | -81.5% | |
| DSGN | New | DESIGN THERAPEUTICS INC | $118,689 | – | 11,568 | +100.0% | 0.03% | – |
| FNCH | FINCH THERAPEUTICS GROUP INC | $114,026 | -71.3% | 237,553 | 0.0% | 0.03% | -64.6% | |
| SPPI | SPECTRUM PHARMACEUTICALS INC | $65,217 | -14.2% | 176,980 | 0.0% | 0.02% | +6.7% | |
| CRBP | CORBUS PHARMACEUTICALS HLDGS | $43,888 | -33.5% | 397,168 | 0.0% | 0.01% | -15.4% | |
| MDGL | New | MADRIGAL PHARMACEUTICALS INC | $21,770 | – | 75 | +100.0% | 0.01% | – |
| TCDA | Sell | TRICIDA INCcall | $22,277 | -99.6% | 145,700 | -74.8% | 0.01% | -99.6% |
| GOSS | Sell | GOSSAMER BIO INC | $13,237 | -99.8% | 6,100 | -99.0% | 0.00% | -99.8% |
| DSGN | New | DESIGN THERAPEUTICS INCcall | $8,208 | – | 800 | +100.0% | 0.00% | – |
| ERYP | ERYTECH PHARMAsponsored adr | $1,185 | -40.8% | 3,019 | 0.0% | 0.00% | – | |
| KDNY | CHINOOK THERAPEUTICS INC | $0 | – | 283,464 | 0.0% | 0.00% | – | |
| IVA | Exit | INVENTIVA SAads | $0 | – | -13,236 | -100.0% | -0.01% | – |
| RETA | Exit | REATA PHARMACEUTICALS INCcl a | $0 | – | -4,064 | -100.0% | -0.02% | – |
| MITO | Exit | STEALTH BIOTHERAPEUTICS CORPsponsored ads | $0 | – | -435,516 | -100.0% | -0.03% | – |
| PRAX | Exit | PRAXIS PRECISION MEDICINES Icall | $0 | – | -74,200 | -100.0% | -0.03% | – |
| GOSS | Exit | GOSSAMER BIO INCput | $0 | – | -17,400 | -100.0% | -0.04% | – |
| CLVS | Exit | CLOVIS ONCOLOGY INC | $0 | – | -361,518 | -100.0% | -0.09% | – |
| CLNN | Exit | CLENE INCput | $0 | – | -177,400 | -100.0% | -0.10% | – |
| ALNY | Exit | ALNYLAM PHARMACEUTICALS INC | $0 | – | -2,800 | -100.0% | -0.11% | – |
| Exit | RENOVACOR INC | $0 | – | -288,119 | -100.0% | -0.14% | – | |
| MCRB | Exit | SERES THERAPEUTICS INC | $0 | – | -131,310 | -100.0% | -0.17% | – |
| BLU | Exit | BELLUS HEALTH INC NEWcall | $0 | – | -85,200 | -100.0% | -0.18% | – |
| CLNN | Exit | CLENE INCcall | $0 | – | -322,600 | -100.0% | -0.18% | – |
| AKRO | Exit | AKERO THERAPEUTICS INCcall | $0 | – | -40,900 | -100.0% | -0.28% | – |
| Exit | CINCOR PHARMA INC | $0 | – | -45,100 | -100.0% | -0.30% | – | |
| MIST | Exit | MILESTONE PHARMACEUTICALS INcall | $0 | – | -180,300 | -100.0% | -0.33% | – |
| INSM | Exit | INSMED INCcall | $0 | – | -100,000 | -100.0% | -0.43% | – |
| DCPH | Exit | DECIPHERA PHARMACEUTICALS INcall | $0 | – | -122,600 | -100.0% | -0.45% | – |
| STSA | Exit | SATSUMA PHARMACEUTICALS INCcall | $0 | – | -400,000 | -100.0% | -0.48% | – |
| RVNC | Exit | REVANCE THERAPEUTICS INC | $0 | – | -100,000 | -100.0% | -0.54% | – |
| MIST | Exit | MILESTONE PHARMACEUTICALS INput | $0 | – | -338,000 | -100.0% | -0.62% | – |
| SCPH | Exit | SCPHARMACEUTICALS INC | $0 | – | -479,383 | -100.0% | -0.62% | – |
| RETA | Exit | REATA PHARMACEUTICALS INCcall | $0 | – | -138,100 | -100.0% | -0.69% | – |
| PRTA | Exit | PROTHENA CORP PLCcall | $0 | – | -66,800 | -100.0% | -0.81% | – |
| STOK | Exit | STOKE THERAPEUTICS INCput | $0 | – | -368,700 | -100.0% | -0.94% | – |
| CERE | Exit | CEREVEL THERAPEUTICS HLDNG I | $0 | – | -178,100 | -100.0% | -1.00% | – |
| HZNP | Exit | HORIZON THERAPEUTICS PUB Lcall | $0 | – | -85,100 | -100.0% | -1.05% | – |
| GOSS | Exit | GOSSAMER BIO INCcall | $0 | – | -526,600 | -100.0% | -1.26% | – |
| Exit | AMYLYX PHARMACEUTICALS INCcall | $0 | – | -250,000 | -100.0% | -1.40% | – | |
| TCDA | Exit | TRICIDA INCput | $0 | – | -727,900 | -100.0% | -1.52% | – |
| ISEE | Exit | IVERIC BIO INCcall | $0 | – | -437,900 | -100.0% | -1.56% | – |
| SRPT | Exit | SAREPTA THERAPEUTICS INCcall | $0 | – | -85,200 | -100.0% | -1.88% | – |
| Exit | DICE THERAPEUTICS INCput | $0 | – | -504,100 | -100.0% | -2.04% | – | |
| BIIB | Exit | BIOGEN INCput | $0 | – | -53,200 | -100.0% | -2.83% | – |
| Exit | DICE THERAPEUTICS INCcall | $0 | – | -748,900 | -100.0% | -3.03% | – | |
| AXSM | Exit | AXSOME THERAPEUTICS INCput | $0 | – | -407,600 | -100.0% | -3.62% | – |
| SGEN | Exit | SEAGEN INCcall | $0 | – | -150,000 | -100.0% | -4.09% | – |
| SPY | Exit | SPDR S&P 500 ETF TRput | $0 | – | -60,000 | -100.0% | -4.27% | – |
| RLMD | Exit | RELMADA THERAPEUTICS INCcall | $0 | – | -775,300 | -100.0% | -5.72% | – |
| RLMD | Exit | RELMADA THERAPEUTICS INCput | $0 | – | -775,300 | -100.0% | -5.72% | – |
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2023-02-14
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| XENON PHARMACEUTICALS INC | 15 | Q2 2023 | 1.5% |
| OCULAR THERAPEUTIX INC | 15 | Q3 2023 | 1.4% |
| SAREPTA THERAPEUTICS INC | 14 | Q3 2023 | 6.4% |
| X4 PHARMACEUTICALS INC - PIPE | 14 | Q2 2023 | 1.4% |
| PROTARA THERAPEUTICS INC | 14 | Q3 2023 | 1.2% |
| SPDR SER TR | 13 | Q3 2023 | 9.0% |
| VAXCYTE INC | 13 | Q3 2023 | 2.9% |
| TRACON PHARMACEUTICALS INC | 13 | Q3 2023 | 1.4% |
| MILESTONE PHARMACEUTICALS IN | 13 | Q3 2023 | 1.7% |
| BELLUS HEALTH INC NEW | 13 | Q1 2023 | 1.8% |
View Ikarian Capital, LLC's complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Milestone Pharmaceuticals Inc. | February 14, 2023 | 460,416 | 1.3% |
| X4 Pharmaceuticals, Inc | February 14, 2023 | 349,133 | 0.3% |
| aTYR PHARMA INC | February 14, 2022 | 35,048 | 0.1% |
| Cyclacel Pharmaceuticals, Inc. | February 14, 2022 | 99,422 | 1.0% |
| KalVista Pharmaceuticals, Inc. | February 14, 2022 | 36,576 | 0.2% |
| Lyra Therapeutics, Inc. | February 14, 2022 | 394,536 | 3.0% |
| Odonate Therapeutics, Inc. | February 14, 2022 | 1,340,631 | 3.5% |
| Protara Therapeutics, Inc. | February 14, 2022 | 279,256 | 2.5% |
| Science 37 Holdings, Inc.Sold out | February 14, 2022 | 0 | 0.0% |
| scPharmaceuticals Inc. | February 14, 2022 | 901,362 | 3.3% |
View Ikarian Capital, LLC's complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| SC 13G/A | 2024-04-05 |
| 13F-HR | 2024-02-14 |
| SC 13G/A | 2024-02-14 |
| 13F-HR | 2023-11-14 |
| 13F-HR | 2023-08-14 |
| 13F-HR | 2023-05-15 |
| SC 13G/A | 2023-02-14 |
| SC 13G/A | 2023-02-14 |
| SC 13G/A | 2023-02-14 |
| SC 13G/A | 2023-02-14 |
View Ikarian Capital, LLC's complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.