$466 Million is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 64 reported holdings in Q4 2022. The portfolio turnover from Q3 2022 to Q4 2022 was 64.9% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| New | INVESCO QQQ TRcall | $61,510,680 | – | 231,000 | +100.0% | 13.20% | – | |
| Sell | INVESCO QQQ TRput | $55,918,800 | -35.7% | 210,000 | -35.5% | 12.00% | -0.6% | |
| AZN | Sell | ASTRAZENECA PLCsponsored adr | $27,124,068 | -44.9% | 400,060 | -55.4% | 5.82% | -14.7% |
| SNY | Sell | SANOFIsponsored adr | $27,097,311 | -41.3% | 559,515 | -53.9% | 5.82% | -9.3% |
| Buy | TEVA PHARMACEUTICAL INDS LTDcall | $20,267,376 | +13.6% | 2,222,300 | +0.6% | 4.35% | +75.7% | |
| JNJ | Sell | JOHNSON & JOHNSON | $19,401,646 | -45.1% | 109,831 | -49.2% | 4.16% | -15.0% |
| SNDX | Sell | SYNDAX PHARMACEUTICALS INC | $18,083,777 | -8.5% | 710,561 | -13.6% | 3.88% | +41.4% |
| MRK | Sell | MERCK & CO INC | $13,380,570 | -57.7% | 120,600 | -67.1% | 2.87% | -34.5% |
| CRNX | Buy | CRINETICS PHARMACEUTICALS IN | $12,291,085 | -0.1% | 671,644 | +7.2% | 2.64% | +54.4% |
| ALBO | Buy | ALBIREO PHARMA INC | $10,023,323 | +44.2% | 463,828 | +29.2% | 2.15% | +122.9% |
| ABBV | Sell | ABBVIE INC | $9,696,600 | -55.5% | 60,000 | -63.0% | 2.08% | -31.2% |
| NVO | Sell | NOVO-NORDISK A Sadr | $9,682,224 | -67.2% | 71,540 | -75.9% | 2.08% | -49.3% |
| LLY | Sell | LILLY ELI & CO | $9,398,430 | -79.8% | 25,690 | -82.1% | 2.02% | -68.7% |
| KZR | Buy | KEZAR LIFE SCIENCES INC | $9,188,446 | -14.3% | 1,305,183 | +4.8% | 1.97% | +32.4% |
| RARE | Buy | ULTRAGENYX PHARMACEUTICAL IN | $8,510,636 | +18.3% | 183,696 | +5.8% | 1.83% | +83.1% |
| SWTX | Buy | SPRINGWORKS THERAPEUTICS INC | $8,235,416 | -4.3% | 316,625 | +5.0% | 1.77% | +48.1% |
| KROS | Sell | KEROS THERAPEUTICS INC | $7,623,511 | -2.0% | 158,757 | -23.2% | 1.64% | +51.5% |
| Sell | ARCELLX INC | $7,357,378 | +17.3% | 237,488 | -28.9% | 1.58% | +81.5% | |
| New | ASTRIA THERAPEUTICS INC | $6,988,473 | – | 469,340 | +100.0% | 1.50% | – | |
| New | TOWER SEMICONDUCTOR LTDput | $6,981,120 | – | 161,600 | +100.0% | 1.50% | – | |
| PNT | Sell | POINT BIOPHARMA GLOBAL INC | $6,944,760 | -14.7% | 952,642 | -9.5% | 1.49% | +31.9% |
| KURA | Sell | KURA ONCOLOGY INC | $6,928,342 | -35.8% | 558,287 | -29.3% | 1.49% | -0.7% |
| IMTX | Sell | IMMATICS N.V | $6,801,221 | -14.5% | 780,852 | -1.8% | 1.46% | +32.2% |
| Buy | CINCOR PHARMA INC | $6,509,276 | +66.7% | 529,640 | +345.3% | 1.40% | +157.7% | |
| FIVN | New | FIVE9 INC | $6,446,600 | – | 95,000 | +100.0% | 1.38% | – |
| ALT | Sell | ALTIMMUNE INC | $6,255,902 | -18.4% | 380,298 | -36.6% | 1.34% | +26.2% |
| CNCE | Buy | CONCERT PHARMACEUTICALS INC | $5,856,253 | -8.3% | 1,002,783 | +5.2% | 1.26% | +41.9% |
| XBI | New | SPDR SER TRs&p biotech | $5,810,000 | – | 70,000 | +100.0% | 1.25% | – |
| GNRC | New | GENERAC HLDGS INC | $5,032,995 | – | 50,000 | +100.0% | 1.08% | – |
| MRUS | Buy | MERUS N V | $4,903,882 | -21.9% | 316,993 | +1.2% | 1.05% | +20.8% |
| KNSA | New | KINIKSA PHARMACEUTICALS LTD | $4,603,099 | – | 307,283 | +100.0% | 0.99% | – |
| New | LEONARDO DRS INC | $4,288,418 | – | 335,557 | +100.0% | 0.92% | – | |
| ISEE | Sell | IVERIC BIO INC | $4,187,603 | -59.9% | 195,591 | -66.4% | 0.90% | -38.0% |
| BLU | Buy | BELLUS HEALTH INC NEW | $4,026,649 | -18.0% | 489,860 | +5.4% | 0.86% | +26.9% |
| FIVERR INTL LTDnote 11/0 | $4,013,955 | +2.9% | 4,951,000 | 0.0% | 0.86% | +59.1% | ||
| RIGL | Buy | RIGEL PHARMACEUTICALS INC | $3,418,268 | +33.9% | 2,278,845 | +5.4% | 0.73% | +107.3% |
| KDNY | Sell | CHINOOK THERAPEUTICS INC | $3,332,640 | -68.3% | 127,200 | -76.2% | 0.72% | -51.0% |
| New | APELLIS PHARMACEUTICALS INCput | $3,102,600 | – | 60,000 | +100.0% | 0.67% | – | |
| CAMT | New | CAMTEK LTDord | $2,415,600 | – | 110,000 | +100.0% | 0.52% | – |
| RZLT | REZOLUTE INC | $2,392,707 | -24.4% | 1,155,897 | 0.0% | 0.51% | +16.8% | |
| ETNB | Sell | 89BIO INC | $2,299,038 | -39.7% | 180,600 | -72.6% | 0.49% | -6.8% |
| BIIB | Sell | BIOGEN INC | $2,081,331 | -86.0% | 7,516 | -86.5% | 0.45% | -78.3% |
| STOK | Buy | STOKE THERAPEUTICS INC | $1,741,147 | -13.7% | 188,640 | +20.0% | 0.37% | +33.6% |
| INZY | Buy | INOZYME PHARMA INC | $1,706,311 | -45.8% | 1,625,058 | +38.3% | 0.37% | -16.2% |
| PMVP | PMV PHARMACEUTICALS INC | $1,633,860 | -26.9% | 187,800 | 0.0% | 0.35% | +13.2% | |
| BCAB | New | BIOATLA INC | $1,539,450 | – | 186,600 | +100.0% | 0.33% | – |
| ALPN | ALPINE IMMUNE SCIENCES INC | $1,470,000 | +2.1% | 200,000 | 0.0% | 0.32% | +57.5% | |
| HOWL | WEREWOLF THERAPEUTICS INC | $1,284,961 | -54.5% | 626,810 | 0.0% | 0.28% | -29.6% | |
| New | MEDIWOUND LTD | $1,017,321 | – | 75,413 | +100.0% | 0.22% | – | |
| AUTL | New | AUTOLUS THERAPEUTICS PLCspon ads | $950,000 | – | 500,000 | +100.0% | 0.20% | – |
| AMAT | New | APPLIED MATLS INC | $827,558 | – | 8,499 | +100.0% | 0.18% | – |
| INFI | INFINITY PHARMACEUTICALS INC | $819,180 | -53.3% | 1,476,000 | 0.0% | 0.18% | -27.9% | |
| NICE SYS INCnote 1.250% 1/1 | $576,550 | +1.0% | 250,000 | 0.0% | 0.12% | +57.0% | ||
| TBLA | New | TABOOLA.COM LTD | $369,600 | – | 120,000 | +100.0% | 0.08% | – |
| MGIC | Sell | MAGIC SOFTWARE ENTERPRISES Lord | $352,199 | -72.2% | 21,981 | -73.0% | 0.08% | -56.8% |
| IMTXW | IMMATICS N.V*w exp 07/01/202 | $251,000 | -7.4% | 100,000 | 0.0% | 0.05% | +42.1% | |
| AGLE | New | AEGLEA BIOTHERAPEUTICS INC | $198,333 | – | 440,837 | +100.0% | 0.04% | – |
| CYCC | CYCLACEL PHARMACEUTICALS INC | $166,750 | -54.3% | 250,000 | 0.0% | 0.04% | -29.4% | |
| OTONOMO TECHNOLOGIES LTDordinary shares | $159,488 | +43.7% | 391,863 | 0.0% | 0.03% | +126.7% | ||
| ARBE ROBOTICS LTDordinary shares | $147,193 | -43.2% | 43,165 | 0.0% | 0.03% | -11.1% | ||
| ONCR | ONCORUS INC | $136,847 | -70.2% | 540,258 | 0.0% | 0.03% | -54.7% | |
| DYN | New | DYNE THERAPEUTICS INC | $82,857 | – | 7,149 | +100.0% | 0.02% | – |
| New | 89BIO INCcall | $45,828 | – | 3,600 | +100.0% | 0.01% | – | |
| New | OUTBRAIN INC | $43,976 | – | 12,148 | +100.0% | 0.01% | – | |
| U | Exit | UNITY SOFTWARE INC | $0 | – | -11,500 | -100.0% | -0.05% | – |
| Exit | WIX COM LTDnote 8/1 | $0 | – | -700,000 | -100.0% | -0.08% | – | |
| EWTX | Exit | EDGEWISE THERAPEUTICS INC | $0 | – | -60,000 | -100.0% | -0.08% | – |
| NICE | Exit | NICE LTDsponsored adr | $0 | – | -3,145 | -100.0% | -0.08% | – |
| ICL | Exit | ICL GROUP LTD | $0 | – | -111,482 | -100.0% | -0.13% | – |
| MDWD | Exit | MEDIWOUND LTD | $0 | – | -688,716 | -100.0% | -0.13% | – |
| PSTX | Exit | POSEIDA THERAPEUTICS INC | $0 | – | -300,000 | -100.0% | -0.15% | – |
| VRNA | Exit | VERONA PHARMA PLCsponsored ads | $0 | – | -120,000 | -100.0% | -0.17% | – |
| Exit | ALTIMMUNE INCput | $0 | – | -100,000 | -100.0% | -0.18% | – | |
| RUN | Exit | SUNRUN INC | $0 | – | -65,000 | -100.0% | -0.25% | – |
| Exit | DICE THERAPEUTICS INCput | $0 | – | -150,000 | -100.0% | -0.42% | – | |
| Exit | DICE THERAPEUTICS INC | $0 | – | -152,913 | -100.0% | -0.43% | – | |
| Exit | RELMADA THERAPEUTICS INCput | $0 | – | -93,000 | -100.0% | -0.48% | – | |
| Exit | SENTINELONE INCcall | $0 | – | -164,800 | -100.0% | -0.58% | – | |
| NVDA | Exit | NVIDIA CORPORATION | $0 | – | -40,000 | -100.0% | -0.67% | – |
| TEVA | Exit | TEVA PHARMACEUTICAL INDS LTDsponsored ads | $0 | – | -776,346 | -100.0% | -0.87% | – |
| Exit | GENERAC HLDGS INCcall | $0 | – | -35,600 | -100.0% | -0.88% | – | |
| GILD | Exit | GILEAD SCIENCES INC | $0 | – | -105,090 | -100.0% | -0.90% | – |
| SEDG | Exit | SOLAREDGE TECHNOLOGIES INC | $0 | – | -29,426 | -100.0% | -0.94% | – |
| RLMD | Exit | RELMADA THERAPEUTICS INC | $0 | – | -193,230 | -100.0% | -0.99% | – |
| S | Exit | SENTINELONE INCcl a | $0 | – | -280,000 | -100.0% | -0.99% | – |
| Exit | PERION NETWORK LTD | $0 | – | -405,184 | -100.0% | -1.08% | – | |
| ADBE | Exit | ADOBE SYSTEMS INCORPORATED | $0 | – | -29,150 | -100.0% | -1.11% | – |
| GLBE | Exit | GLOBAL E ONLINE LTD | $0 | – | -311,460 | -100.0% | -1.16% | – |
| KRNT | Exit | KORNIT DIGITAL LTD | $0 | – | -322,926 | -100.0% | -1.19% | – |
| WIX | Exit | WIX COM LTD | $0 | – | -129,000 | -100.0% | -1.40% | – |
| PANW | Exit | PALO ALTO NETWORKS INC | $0 | – | -63,000 | -100.0% | -1.43% | – |
| Exit | UNITY SOFTWARE INCcall | $0 | – | -367,500 | -100.0% | -1.62% | – | |
| Exit | NVIDIA CORPORATIONcall | $0 | – | -172,600 | -100.0% | -2.91% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2023-02-14
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| TEVA PHARMACEUTICAL-SP ADR | 36 | Q3 2023 | 8.4% |
| MERCK & CO INC NEW | 35 | Q3 2023 | 8.4% |
| NICE Systems Ltd | 27 | Q3 2023 | 4.4% |
| BIOGEN INC | 26 | Q3 2023 | 6.7% |
| AMICUS THERAPEUTICS INC | 26 | Q2 2022 | 4.3% |
| PFIZER INC | 25 | Q3 2023 | 9.2% |
| SAREPTA THERAPEUTICS INC | 25 | Q3 2023 | 3.2% |
| JOHNSON & JOHNSON | 24 | Q3 2023 | 8.0% |
| UNIQURE NV | 23 | Q3 2023 | 1.2% |
| SYNDAX PHARMACEUTICALS INC | 22 | Q3 2023 | 3.9% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Cyclacel Pharmaceuticals, Inc. | February 06, 2023 | 250,000 | 2.0% |
| Altimmune, Inc. | February 14, 2022 | 1,244,241 | 3.1% |
| Allot Ltd. | February 16, 2021 | 1,129,054 | 3.2% |
| Larimar Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Neos Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Orgenesis Inc. | February 16, 2021 | 525,216 | 0.0% |
| Sio Gene Therapies Inc. | February 16, 2021 | ? | ? |
| X4 Pharmaceuticals, Inc | February 16, 2021 | 250,000 | 0.0% |
| Axovant Gene Therapies Ltd. | February 25, 2020 | 2,931,017 | 8.0% |
| Axovant Gene Therapies Ltd. | February 11, 2020 | 398,540 | 1.8% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 13F-HR/A | 2024-02-15 |
| 13F-HR | 2024-02-14 |
| SC 13G | 2024-02-08 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| 13F-HR | 2023-11-14 |
| SC 13G | 2023-10-10 |
| SC 13G | 2023-08-30 |
View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.