$598 Million is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 81 reported holdings in Q1 2023. The portfolio turnover from Q4 2022 to Q1 2023 was 95.3% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| IWM | New | ISHARES TRput | $75,088,557 | – | 420,900 | +100.0% | 12.55% | – |
| SPY | New | SPDR S&P 500 ETF TRput | $30,704,251 | – | 75,000 | +100.0% | 5.13% | – |
| SNY | Sell | SANOFIsponsored adr | $28,816,206 | +6.3% | 529,515 | -5.4% | 4.82% | -17.2% |
| NICE | New | NICE LTDsponsored adr | $26,432,675 | – | 115,482 | +100.0% | 4.42% | – |
| AZN | Sell | ASTRAZENECA PLCsponsored adr | $19,786,015 | -27.1% | 285,060 | -28.7% | 3.31% | -43.2% |
| JNJ | Buy | JOHNSON & JOHNSON | $18,573,805 | -4.3% | 119,831 | +9.1% | 3.10% | -25.5% |
| TEVA | New | TEVA PHARMACEUTICAL INDS LTDsponsored ads | $18,049,575 | – | 2,039,500 | +100.0% | 3.02% | – |
| TEVA | New | TEVA PHARMACEUTICAL INDS LTDcall | $18,027,451 | – | 2,037,000 | +100.0% | 3.01% | – |
| MSFT | New | MICROSOFT CORP | $15,747,811 | – | 54,623 | +100.0% | 2.63% | – |
| SNDX | Sell | SYNDAX PHARMACEUTICALS INC | $14,426,248 | -20.2% | 683,061 | -3.9% | 2.41% | -37.9% |
| MRK | MERCK & CO INC | $12,830,634 | -4.1% | 120,600 | 0.0% | 2.14% | -25.3% | |
| NVO | NOVO-NORDISK A Sadr | $11,384,876 | +17.6% | 71,540 | 0.0% | 1.90% | -8.4% | |
| New | ENPHASE ENERGY INCnote 3/0 | $11,190,251 | – | 10,725,000 | +100.0% | 1.87% | – | |
| LLY | Buy | LILLY ELI & CO | $10,882,980 | +15.8% | 31,690 | +23.4% | 1.82% | -9.8% |
| NTR | New | NUTRIEN LTD | $10,742,664 | – | 145,466 | +100.0% | 1.80% | – |
| INZY | Buy | INOZYME PHARMA INC | $10,210,046 | +498.4% | 1,781,858 | +9.6% | 1.71% | +366.1% |
| ABBV | Buy | ABBVIE INC | $10,040,310 | +3.5% | 63,000 | +5.0% | 1.68% | -19.4% |
| BBIO | New | BRIDGEBIO PHARMA INC | $9,317,678 | – | 561,983 | +100.0% | 1.56% | – |
| BIIB | Buy | BIOGEN INC | $9,318,453 | +347.7% | 33,516 | +345.9% | 1.56% | +248.3% |
| AMZN | New | AMAZON COM INC | $8,849,887 | – | 85,680 | +100.0% | 1.48% | – |
| QQQ | New | INVESCO QQQ TRunit ser 1 | $8,457,468 | – | 26,353 | +100.0% | 1.41% | – |
| SWTX | Buy | SPRINGWORKS THERAPEUTICS INC | $8,175,668 | -0.7% | 317,625 | +0.3% | 1.37% | -22.7% |
| PTCT | New | PTC THERAPEUTICS INC | $7,706,804 | – | 159,100 | +100.0% | 1.29% | – |
| New | ENLIGHT RENEWABLE ENERGY LTD | $7,628,619 | – | 450,864 | +100.0% | 1.28% | – | |
| KURA | Buy | KURA ONCOLOGY INC | $7,378,200 | +6.5% | 603,287 | +8.1% | 1.23% | -17.1% |
| RARE | ULTRAGENYX PHARMACEUTICAL IN | $7,366,210 | -13.4% | 183,696 | 0.0% | 1.23% | -32.6% | |
| New | JASPER THERAPEUTICS INC | $7,319,654 | – | 4,044,008 | +100.0% | 1.22% | – | |
| PNT | POINT BIOPHARMA GLOBAL INC | $6,925,707 | -0.3% | 952,642 | 0.0% | 1.16% | -22.4% | |
| CAMT | Buy | CAMTEK LTDord | $6,789,655 | +181.1% | 239,494 | +117.7% | 1.14% | +119.1% |
| SAGE | New | SAGE THERAPEUTICS INC | $6,503,800 | – | 155,000 | +100.0% | 1.09% | – |
| MRUS | Buy | MERUS N V | $6,200,671 | +26.4% | 336,993 | +6.3% | 1.04% | -1.5% |
| SRPT | New | SAREPTA THERAPEUTICS INC | $6,064,520 | – | 44,000 | +100.0% | 1.01% | – |
| KZR | Buy | KEZAR LIFE SCIENCES INC | $5,910,154 | -35.7% | 1,888,228 | +44.7% | 0.99% | -49.9% |
| XLI | New | SELECT SECTOR SPDR TRput | $5,838,086 | – | 57,700 | +100.0% | 0.98% | – |
| BLU | Buy | BELLUS HEALTH INC NEW | $5,758,992 | +43.0% | 799,860 | +63.3% | 0.96% | +11.3% |
| PFE | New | PFIZER INC | $5,712,000 | – | 140,000 | +100.0% | 0.96% | – |
| ISEE | Buy | IVERIC BIO INC | $5,634,609 | +34.6% | 231,591 | +18.4% | 0.94% | +4.8% |
| Sell | ASTRIA THERAPEUTICS INC | $5,599,539 | -19.9% | 421,018 | -10.3% | 0.94% | -37.6% | |
| NVS | New | NOVARTIS AGsponsored adr | $5,520,000 | – | 60,000 | +100.0% | 0.92% | – |
| IMTX | IMMATICS N.V | $5,387,879 | -20.8% | 780,852 | 0.0% | 0.90% | -38.4% | |
| New | MINERALYS THERAPEUTICS INC | $5,308,740 | – | 339,000 | +100.0% | 0.89% | – | |
| Sell | ARCELLX INC | $5,160,305 | -29.9% | 167,488 | -29.5% | 0.86% | -45.4% | |
| New | PERION NETWORK LTD | $5,145,400 | – | 130,000 | +100.0% | 0.86% | – | |
| KNSA | Buy | KINIKSA PHARMACEUTICALS LTD | $4,845,045 | +5.3% | 450,283 | +46.5% | 0.81% | -18.0% |
| FUSN | New | FUSION PHARMACEUTICALS INC | $4,838,934 | – | 1,283,537 | +100.0% | 0.81% | – |
| New | DISC MEDICINE INC | $4,662,075 | – | 220,013 | +100.0% | 0.78% | – | |
| MDGL | New | MADRIGAL PHARMACEUTICALS INC | $4,602,940 | – | 19,000 | +100.0% | 0.77% | – |
| GRCL | New | GRACELL BIOTECHNOLOGIES INCsponsored ads | $4,390,679 | – | 2,360,580 | +100.0% | 0.73% | – |
| TVTX | New | TRAVERE THERAPEUTICS INC | $4,216,875 | – | 187,500 | +100.0% | 0.70% | – |
| RCKT | New | ROCKET PHARMACEUTICALS INC | $4,042,680 | – | 236,000 | +100.0% | 0.68% | – |
| PANW | New | PALO ALTO NETWORKS INC | $3,994,800 | – | 20,000 | +100.0% | 0.67% | – |
| QURE | New | UNIQURE NVcall | $3,532,556 | – | 175,400 | +100.0% | 0.59% | – |
| PCVX | New | VAXCYTE INC | $3,373,200 | – | 90,000 | +100.0% | 0.56% | – |
| BBIO | New | BRIDGEBIO PHARMA INCcall | $3,316,000 | – | 200,000 | +100.0% | 0.55% | – |
| COGT | New | COGENT BIOSCIENCES INC | $3,237,000 | – | 300,000 | +100.0% | 0.54% | – |
| SELB | New | SELECTA BIOSCIENCES INC | $3,231,750 | – | 2,325,000 | +100.0% | 0.54% | – |
| MIRM | New | MIRUM PHARMACEUTICALS INC | $2,626,251 | – | 109,336 | +100.0% | 0.44% | – |
| DYN | Buy | DYNE THERAPEUTICS INC | $2,526,520 | +2949.3% | 219,316 | +2967.8% | 0.42% | +2244.4% |
| RIGL | Sell | RIGEL PHARMACEUTICALS INC | $2,480,075 | -27.4% | 1,878,845 | -17.6% | 0.41% | -43.6% |
| AMGN | New | AMGEN INC | $2,417,500 | – | 10,000 | +100.0% | 0.40% | – |
| RZLT | REZOLUTE INC | $2,219,322 | -7.2% | 1,155,897 | 0.0% | 0.37% | -27.8% | |
| KDNY | Sell | CHINOOK THERAPEUTICS INC | $2,134,430 | -36.0% | 92,200 | -27.5% | 0.36% | -50.1% |
| HOWL | WEREWOLF THERAPEUTICS INC | $1,629,706 | +26.8% | 626,810 | 0.0% | 0.27% | -1.4% | |
| ALPN | ALPINE IMMUNE SCIENCES INC | $1,544,000 | +5.0% | 200,000 | 0.0% | 0.26% | -18.1% | |
| Buy | MEDIWOUND LTD | $1,480,212 | +45.5% | 111,127 | +47.4% | 0.25% | +13.3% | |
| CRNX | Sell | CRINETICS PHARMACEUTICALS IN | $1,328,917 | -89.2% | 82,747 | -87.7% | 0.22% | -91.6% |
| KROS | Sell | KEROS THERAPEUTICS INC | $1,286,081 | -83.1% | 30,119 | -81.0% | 0.22% | -86.9% |
| ALT | Sell | ALTIMMUNE INC | $1,266,000 | -79.8% | 300,000 | -21.1% | 0.21% | -84.2% |
| QURE | New | UNIQURE NV | $1,248,680 | – | 62,000 | +100.0% | 0.21% | – |
| ANNX | New | ANNEXON INC | $962,500 | – | 250,000 | +100.0% | 0.16% | – |
| PMVP | PMV PHARMACEUTICALS INC | $895,806 | -45.2% | 187,800 | 0.0% | 0.15% | -57.3% | |
| RETA | New | REATA PHARMACEUTICALS INCcl a | $699,084 | – | 7,689 | +100.0% | 0.12% | – |
| INFI | INFINITY PHARMACEUTICALS INC | $236,160 | -71.2% | 1,476,000 | 0.0% | 0.04% | -77.8% | |
| Sell | FIVERR INTL LTDnote 11/0 | $208,223 | -94.8% | 250,000 | -95.0% | 0.04% | -95.9% | |
| ONCR | ONCORUS INC | $185,903 | +35.8% | 540,258 | 0.0% | 0.03% | +6.9% | |
| OTONOMO TECHNOLOGIES LTDordinary shares | $186,409 | +16.9% | 391,863 | 0.0% | 0.03% | -8.8% | ||
| AGLE | Buy | AEGLEA BIOTHERAPEUTICS INC | $187,479 | -5.5% | 646,478 | +46.6% | 0.03% | -27.9% |
| IMTXW | IMMATICS N.V*w exp 07/01/202 | $144,000 | -42.6% | 100,000 | 0.0% | 0.02% | -55.6% | |
| CYCC | CYCLACEL PHARMACEUTICALS INC | $142,625 | -14.5% | 250,000 | 0.0% | 0.02% | -33.3% | |
| ARBE ROBOTICS LTDordinary shares | $137,696 | -6.5% | 43,165 | 0.0% | 0.02% | -28.1% | ||
| MRSN | New | MERSANA THERAPEUTICS INC | $43,652 | – | 10,621 | +100.0% | 0.01% | – |
| Exit | OUTBRAIN INC | $0 | – | -12,148 | -100.0% | -0.01% | – | |
| Exit | 89BIO INCcall | $0 | – | -3,600 | -100.0% | -0.01% | – | |
| MGIC | Exit | MAGIC SOFTWARE ENTERPRISES Lord | $0 | – | -21,981 | -100.0% | -0.08% | – |
| TBLA | Exit | TABOOLA.COM LTD | $0 | – | -120,000 | -100.0% | -0.08% | – |
| Exit | NICE SYS INCnote 1.250% 1/1 | $0 | – | -250,000 | -100.0% | -0.12% | – | |
| AMAT | Exit | APPLIED MATLS INC | $0 | – | -8,499 | -100.0% | -0.18% | – |
| AUTL | Exit | AUTOLUS THERAPEUTICS PLCspon ads | $0 | – | -500,000 | -100.0% | -0.20% | – |
| BCAB | Exit | BIOATLA INC | $0 | – | -186,600 | -100.0% | -0.33% | – |
| STOK | Exit | STOKE THERAPEUTICS INC | $0 | – | -188,640 | -100.0% | -0.37% | – |
| ETNB | Exit | 89BIO INC | $0 | – | -180,600 | -100.0% | -0.49% | – |
| Exit | APELLIS PHARMACEUTICALS INCput | $0 | – | -60,000 | -100.0% | -0.67% | – | |
| Exit | LEONARDO DRS INC | $0 | – | -335,557 | -100.0% | -0.92% | – | |
| GNRC | Exit | GENERAC HLDGS INC | $0 | – | -50,000 | -100.0% | -1.08% | – |
| XBI | Exit | SPDR SER TRs&p biotech | $0 | – | -70,000 | -100.0% | -1.25% | – |
| CNCE | Exit | CONCERT PHARMACEUTICALS INC | $0 | – | -1,002,783 | -100.0% | -1.26% | – |
| FIVN | Exit | FIVE9 INC | $0 | – | -95,000 | -100.0% | -1.38% | – |
| Exit | CINCOR PHARMA INC | $0 | – | -529,640 | -100.0% | -1.40% | – | |
| Exit | TOWER SEMICONDUCTOR LTDput | $0 | – | -161,600 | -100.0% | -1.50% | – | |
| ALBO | Exit | ALBIREO PHARMA INC | $0 | – | -463,828 | -100.0% | -2.15% | – |
| Exit | TEVA PHARMACEUTICAL INDS LTDcall | $0 | – | -2,222,300 | -100.0% | -4.35% | – | |
| Exit | INVESCO QQQ TRput | $0 | – | -210,000 | -100.0% | -12.00% | – | |
| Exit | INVESCO QQQ TRcall | $0 | – | -231,000 | -100.0% | -13.20% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2023-05-15
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| TEVA PHARMACEUTICAL-SP ADR | 36 | Q3 2023 | 8.4% |
| MERCK & CO INC NEW | 35 | Q3 2023 | 8.4% |
| NICE Systems Ltd | 27 | Q3 2023 | 4.4% |
| BIOGEN INC | 26 | Q3 2023 | 6.7% |
| AMICUS THERAPEUTICS INC | 26 | Q2 2022 | 4.3% |
| PFIZER INC | 25 | Q3 2023 | 9.2% |
| SAREPTA THERAPEUTICS INC | 25 | Q3 2023 | 3.2% |
| JOHNSON & JOHNSON | 24 | Q3 2023 | 8.0% |
| UNIQURE NV | 23 | Q3 2023 | 1.2% |
| SYNDAX PHARMACEUTICALS INC | 22 | Q3 2023 | 3.9% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Cyclacel Pharmaceuticals, Inc. | February 06, 2023 | 250,000 | 2.0% |
| Altimmune, Inc. | February 14, 2022 | 1,244,241 | 3.1% |
| Allot Ltd. | February 16, 2021 | 1,129,054 | 3.2% |
| Larimar Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Neos Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Orgenesis Inc. | February 16, 2021 | 525,216 | 0.0% |
| Sio Gene Therapies Inc. | February 16, 2021 | ? | ? |
| X4 Pharmaceuticals, Inc | February 16, 2021 | 250,000 | 0.0% |
| Axovant Gene Therapies Ltd. | February 25, 2020 | 2,931,017 | 8.0% |
| Axovant Gene Therapies Ltd. | February 11, 2020 | 398,540 | 1.8% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 13F-HR/A | 2024-02-15 |
| 13F-HR | 2024-02-14 |
| SC 13G | 2024-02-08 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| 13F-HR | 2023-11-14 |
| SC 13G | 2023-10-10 |
| SC 13G | 2023-08-30 |
View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.