$1.3 Billion is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 170 reported holdings in Q1 2021. The portfolio turnover from Q4 2020 to Q1 2021 was 132.7% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| LLY | Buy | LILLY ELI & CO | $80,183,000 | +15.8% | 429,200 | +4.7% | 6.15% | +0.1% |
| JNJ | Buy | JOHNSON & JOHNSON | $74,598,000 | +40.2% | 453,900 | +34.2% | 5.72% | +21.1% |
| ABBV | Buy | ABBVIE INC | $64,878,000 | +78.1% | 599,500 | +76.3% | 4.98% | +53.9% |
| MRK | Buy | MERCK & CO. INC | $62,351,000 | +4.6% | 808,808 | +11.0% | 4.78% | -9.6% |
| SNY | New | SANOFIsponsored adr | $49,356,000 | – | 997,900 | +100.0% | 3.79% | – |
| AZN | Buy | ASTRAZENECA PLCsponsored adr | $47,755,000 | +38.4% | 960,473 | +39.1% | 3.66% | +19.6% |
| IWM | New | ISHARES TRput | $46,397,000 | – | 210,000 | +100.0% | 3.56% | – |
| ENPH | New | ENPHASE ENERGY INCcall | $37,297,000 | – | 230,000 | +100.0% | 2.86% | – |
| GNRC | GENERAC HLDGS INC | $34,599,000 | +44.0% | 105,663 | 0.0% | 2.65% | +24.4% | |
| JNJ | New | JOHNSON & JOHNSONcall | $32,870,000 | – | 200,000 | +100.0% | 2.52% | – |
| IGV | New | ISHARES TRput | $24,207,000 | – | 70,900 | +100.0% | 1.86% | – |
| FVRR | New | FIVERR INTL LTDcall | $21,718,000 | – | 100,000 | +100.0% | 1.67% | – |
| KURA | Buy | KURA ONCOLOGY INC | $20,291,000 | +31.8% | 717,751 | +52.2% | 1.56% | +13.8% |
| CCCC | Buy | C4 THERAPEUTICS INC | $18,389,000 | +25.9% | 497,136 | +12.0% | 1.41% | +8.8% |
| MSFT | Buy | MICROSOFT CORP | $15,923,000 | +50.6% | 67,536 | +42.1% | 1.22% | +30.2% |
| KRNT | Buy | KORNIT DIGITAL LTD | $14,708,000 | +28.5% | 148,381 | +15.6% | 1.13% | +11.0% |
| SNDX | Sell | SYNDAX PHARMACEUTICALS INC | $14,268,000 | -14.0% | 638,093 | -14.5% | 1.09% | -25.7% |
| LPSN | New | LIVEPERSON INC | $13,712,000 | – | 260,000 | +100.0% | 1.05% | – |
| EPIX | Buy | ESSA PHARMA INC | $13,631,000 | +192.8% | 469,241 | +20.3% | 1.04% | +153.0% |
| AUDC | Buy | AUDIOCODES LTDord | $12,832,000 | +8.6% | 475,624 | +10.9% | 0.98% | -6.2% |
| BMY | Sell | BRISTOL-MYERS SQUIBB CO | $12,626,000 | -67.4% | 200,000 | -68.0% | 0.97% | -71.9% |
| ONCR | ONCORUS INC | $12,571,000 | -55.7% | 903,111 | 0.0% | 0.96% | -61.7% | |
| CERE | Buy | CEREVEL THERAPEUTICS HLDNG I | $12,525,000 | -6.9% | 912,240 | +12.4% | 0.96% | -19.5% |
| MWK | New | MOHAWK GROUP HLDGS INCcall | $10,490,000 | – | 355,600 | +100.0% | 0.80% | – |
| PANW | Sell | PALO ALTO NETWORKS INC | $10,403,000 | -22.7% | 32,300 | -14.7% | 0.80% | -33.2% |
| TEVA | New | TEVA PHARMACEUTICAL INDS LTDcall | $10,257,000 | – | 888,800 | +100.0% | 0.79% | – |
| ICLN | New | ISHARES TRput | $10,206,000 | – | 420,000 | +100.0% | 0.78% | – |
| SWTX | Buy | SPRINGWORKS THERAPEUTICS INC | $10,129,000 | +346.2% | 137,672 | +339.8% | 0.78% | +286.6% |
| CRIS | New | CURIS INC | $10,028,000 | – | 885,838 | +100.0% | 0.77% | – |
| ORTX | New | ORCHARD THERAPEUTICS PLCads | $9,921,000 | – | 1,366,564 | +100.0% | 0.76% | – |
| KYMR | Buy | KYMERA THERAPEUTICS INC | $9,619,000 | +5.0% | 247,527 | +67.6% | 0.74% | -9.2% |
| TEVA | TEVA PHARMACEUTICAL INDS LTDsponsored ads | $9,611,000 | +19.6% | 832,878 | 0.0% | 0.74% | +3.4% | |
| ALXO | Sell | ALX ONCOLOGY HLDGS INC | $9,612,000 | -16.4% | 130,351 | -2.3% | 0.74% | -27.8% |
| FATE | Buy | FATE THERAPEUTICS INC | $9,054,000 | +21.4% | 109,807 | +33.9% | 0.69% | +4.8% |
| VTGN | Buy | VISTAGEN THERAPEUTICS INC | $8,897,000 | +68.3% | 4,177,158 | +53.3% | 0.68% | +45.4% |
| ZLAB | New | ZAI LAB LTDadr | $8,778,000 | – | 65,788 | +100.0% | 0.67% | – |
| NICE | Sell | NICE LTDsponsored adr | $8,606,000 | -59.2% | 39,481 | -47.0% | 0.66% | -64.8% |
| AMZN | Buy | AMAZON COM INC | $8,543,000 | +27.3% | 2,761 | +34.0% | 0.66% | +9.9% |
| PRGO | New | PERRIGO CO PLCcall | $8,499,000 | – | 210,000 | +100.0% | 0.65% | – |
| ONTO | New | ONTO INNOVATION INC | $8,214,000 | – | 125,000 | +100.0% | 0.63% | – |
| TLT | New | ISHARES TRput | $8,127,000 | – | 60,000 | +100.0% | 0.62% | – |
| SGTX | Sell | SIGILON THERAPEUTICS INC | $8,072,000 | -69.0% | 362,239 | -36.2% | 0.62% | -73.2% |
| AFMD | New | AFFIMED N V | $8,060,000 | – | 1,018,965 | +100.0% | 0.62% | – |
| BOLT | New | BOLT BIOTHERAPEUTICS INC | $7,931,000 | – | 241,000 | +100.0% | 0.61% | – |
| RPTX | Buy | REPARE THERAPEUTICS INC | $7,614,000 | -1.0% | 248,100 | +10.6% | 0.58% | -14.5% |
| ZNTL | Sell | ZENTALIS PHARMACEUTICALS INC | $7,599,000 | -23.3% | 175,140 | -8.2% | 0.58% | -33.7% |
| RACA | Buy | THERAPEUTICS ACQUISITION COR | $7,567,000 | +2612.2% | 720,000 | +3500.0% | 0.58% | +2220.0% |
| MWK | New | MOHAWK GROUP HLDGS INC | $7,405,000 | – | 251,015 | +100.0% | 0.57% | – |
| CSTE | New | CAESARSTONE LTD | $7,348,000 | – | 535,148 | +100.0% | 0.56% | – |
| SBTX | Sell | SILVERBACK THERAPEUTICS INC | $7,321,000 | -9.3% | 167,799 | -3.7% | 0.56% | -21.6% |
| BLSA | Buy | BCLS ACQUISITION CORP | $7,271,000 | +5.5% | 687,900 | +10.1% | 0.56% | -8.8% |
| BGNE | New | BEIGENE LTDsponsored adr | $7,275,000 | – | 20,900 | +100.0% | 0.56% | – |
| Buy | TRILLIUM THERAPEUTICS INC | $7,201,000 | -21.9% | 670,459 | +7.0% | 0.55% | -32.5% | |
| VRNS | Buy | VARONIS SYS INC | $7,120,000 | -21.2% | 138,675 | +151.1% | 0.55% | -31.9% |
| CYBR | New | CYBERARK SOFTWARE LTD | $7,114,000 | – | 55,000 | +100.0% | 0.55% | – |
| DYN | Buy | DYNE THERAPEUTICS INC | $6,989,000 | +232.8% | 450,064 | +350.1% | 0.54% | +188.2% |
| ALLT | Sell | ALLOT LTD | $6,711,000 | +19.6% | 420,205 | -21.2% | 0.52% | +3.4% |
| STRO | Buy | SUTRO BIOPHARMA INC | $6,710,000 | +53.3% | 294,825 | +46.2% | 0.52% | +32.7% |
| VRNA | Sell | VERONA PHARMA PLCsponsored ads | $6,699,000 | -7.4% | 801,256 | -22.5% | 0.51% | -19.9% |
| COGT | Buy | UNUM THERAPEUTICS INC | $6,695,000 | -18.9% | 762,569 | +3.7% | 0.51% | -29.9% |
| NRIX | New | NURIX THERAPEUTICS INC | $6,687,000 | – | 215,076 | +100.0% | 0.51% | – |
| KALV | Buy | KALVISTA PHARMACEUTICALS INC | $6,651,000 | +45.9% | 258,880 | +7.8% | 0.51% | +25.9% |
| IONS | Buy | IONIS PHARMACEUTICALS INC | $6,541,000 | +26.0% | 145,476 | +58.5% | 0.50% | +8.9% |
| RACB | New | RESEARCH ALLIANCE CORP II | $6,150,000 | – | 600,000 | +100.0% | 0.47% | – |
| STOK | New | STOKE THERAPEUTICS INC | $5,854,000 | – | 150,729 | +100.0% | 0.45% | – |
| ARYA | ARYA SCIENCES ACQUISITION CO | $5,512,000 | +27.0% | 400,000 | 0.0% | 0.42% | +9.9% | |
| BIDU | New | BAIDU INCspon adr rep a | $5,439,000 | – | 25,000 | +100.0% | 0.42% | – |
| PTGX | New | PROTAGONIST THERAPEUTICS INC | $5,235,000 | – | 202,134 | +100.0% | 0.40% | – |
| ARYD | New | ARYA SCIENCES ACQU CORP IVcl a | $5,200,000 | – | 500,000 | +100.0% | 0.40% | – |
| MRTX | MIRATI THERAPEUTICS INC | $5,101,000 | -22.0% | 29,779 | 0.0% | 0.39% | -32.7% | |
| ACHL | New | ACHILLES THERAPEUTICS PLCsponsored ads | $4,965,000 | – | 300,000 | +100.0% | 0.38% | – |
| RADA | New | RADA ELECTR INDS LTD | $4,899,000 | – | 407,925 | +100.0% | 0.38% | – |
| IDYA | New | IDEAYA BIOSCIENCES INC | $4,747,000 | – | 201,984 | +100.0% | 0.36% | – |
| RTPZ | New | REINVENT TECHNOLOGY PARTNERS | $4,685,000 | – | 468,012 | +100.0% | 0.36% | – |
| CLDX | Sell | CELLDEX THERAPEUTICS INC NEW | $4,539,000 | -56.6% | 220,320 | -63.1% | 0.35% | -62.5% |
| MREO | New | MEREO BIOPHARMA GROUP PLCads | $4,423,000 | – | 1,312,415 | +100.0% | 0.34% | – |
| CLOU | New | GLOBAL X FDSput | $4,391,000 | – | 170,600 | +100.0% | 0.34% | – |
| CRNX | New | CRINETICS PHARMACEUTICALS IN | $4,343,000 | – | 284,224 | +100.0% | 0.33% | – |
| FTCH | New | FARFETCH LTDord sh cl a | $4,242,000 | – | 80,000 | +100.0% | 0.32% | – |
| FOREU | New | FORESIGHT ACQUISITION CORPunit 01/29/2026 | $4,162,000 | – | 420,000 | +100.0% | 0.32% | – |
| ORIC | Sell | ORIC PHARMACEUTICALS INC | $4,163,000 | -32.5% | 169,900 | -6.8% | 0.32% | -41.7% |
| STTK | Buy | SHATTUCK LABS INC | $4,113,000 | +41.9% | 140,665 | +154.4% | 0.32% | +22.6% |
| ARKO | Sell | ARKO CORP | $4,056,000 | -24.9% | 408,000 | -32.0% | 0.31% | -35.1% |
| HCCCU | New | HEALTHCARE CAPITAL CORPunit 12/31/2025 | $3,948,000 | – | 400,000 | +100.0% | 0.30% | – |
| IFRX | New | INFLARX NV | $3,900,000 | – | 1,000,000 | +100.0% | 0.30% | – |
| YMTX | Buy | YUMANITY THERAPEUTICS INC | $3,776,000 | +70.3% | 208,609 | +59.9% | 0.29% | +47.2% |
| New | CATABASIS PHARMACEUTICALS IN | $3,740,000 | – | 1,294,000 | +100.0% | 0.29% | – | |
| CYCC | New | CYCLACEL PHARMACEUTICALS INC | $3,614,000 | – | 508,322 | +100.0% | 0.28% | – |
| NKTX | New | NKARTA INC | $3,323,000 | – | 101,006 | +100.0% | 0.26% | – |
| GRCL | New | GRACELL BIOTECHNOLOGIES INCsponsored ads | $3,274,000 | – | 212,600 | +100.0% | 0.25% | – |
| LVTX | New | LAVA THERAPEUTICS NV | $3,249,000 | – | 213,894 | +100.0% | 0.25% | – |
| EWTX | New | EDGEWISE THERAPEUTICS INC | $3,250,000 | – | 100,000 | +100.0% | 0.25% | – |
| LGVU | New | LONGVIEW ACQUISITION CORP IIunit 99/99/9999 | $3,012,000 | – | 300,000 | +100.0% | 0.23% | – |
| EUCR | New | EUCRATES BIOMEDICAL ACQU COR | $3,007,000 | – | 304,025 | +100.0% | 0.23% | – |
| CLRMU | New | CLARIM ACQUISITION CORPunit 99/99/9999 | $2,985,000 | – | 300,000 | +100.0% | 0.23% | – |
| GRTX | Sell | GALERA THERAPEUTICS INC | $2,852,000 | -40.4% | 323,348 | -30.9% | 0.22% | -48.5% |
| GLTO | Buy | GALECTO INC | $2,722,000 | -41.7% | 448,016 | +14.4% | 0.21% | -49.5% |
| IMAB | Sell | I MABsponsored ads | $2,664,000 | -68.9% | 54,962 | -69.8% | 0.20% | -73.2% |
| PHAS | New | PHASEBIO PHARMACEUTICALS INC | $2,595,000 | – | 750,000 | +100.0% | 0.20% | – |
| ARGX | ARGENX SEsponsored adr | $2,547,000 | -6.4% | 9,249 | 0.0% | 0.20% | -19.1% | |
| IMVT | Sell | IMMUNOVANT INC | $2,542,000 | -67.6% | 158,500 | -6.8% | 0.20% | -72.0% |
| LSAQ | Buy | LIFESCI ACQUISITION II CORP | $2,474,000 | +133.0% | 244,000 | +144.0% | 0.19% | +102.1% |
| CAMT | Sell | CAMTEK LTDord | $2,384,000 | -72.8% | 79,746 | -80.1% | 0.18% | -76.5% |
| FNCH | New | FINCH THERAPEUTICS GROUP INC | $2,387,000 | – | 150,000 | +100.0% | 0.18% | – |
| TIL | New | INSTIL BIO INC | $2,383,000 | – | 95,000 | +100.0% | 0.18% | – |
| INBX | Buy | INHIBRX INC | $2,301,000 | +61.6% | 114,643 | +165.5% | 0.18% | +39.7% |
| TMPM | New | TURMERIC ACQUISITION CORPcl a | $2,144,000 | – | 219,440 | +100.0% | 0.16% | – |
| ALPN | ALPINE IMMUNE SCIENCES INC | $2,102,000 | -15.9% | 198,260 | 0.0% | 0.16% | -27.5% | |
| CAPA | New | HIGHCAPE CAP ACQUISITION COR | $2,055,000 | – | 172,396 | +100.0% | 0.16% | – |
| WPF | New | FOLEY TRASIMENE ACQUISTN COR | $2,008,000 | – | 200,000 | +100.0% | 0.15% | – |
| HCAQ | New | HEALTHCOR CATALIO ACQU CORP | $2,000,000 | – | 200,000 | +100.0% | 0.15% | – |
| JYAC | New | JIYA ACQUISITION CORP | $1,958,000 | – | 199,028 | +100.0% | 0.15% | – |
| BIIB | New | BIOGEN INC | $1,902,000 | – | 6,800 | +100.0% | 0.15% | – |
| VINC | Buy | VINCERX PHARMA INC | $1,809,000 | +86.1% | 93,708 | +101.7% | 0.14% | +61.6% |
| EQ | New | EQUILLIUM INC | $1,817,000 | – | 254,184 | +100.0% | 0.14% | – |
| GIGGU | New | GIGCAPITAL4 INCunit 99/99/9999 | $1,727,000 | – | 175,000 | +100.0% | 0.13% | – |
| SVAC | New | STARBOARD VALUE ACQUISITN CO | $1,697,000 | – | 170,937 | +100.0% | 0.13% | – |
| PIRS | Buy | PIERIS PHARMACEUTICALS INC | $1,671,000 | +21.5% | 650,000 | +18.2% | 0.13% | +4.9% |
| DFPH | New | DFP HEALTHCARE ACQUISITNS CO | $1,621,000 | – | 162,759 | +100.0% | 0.12% | – |
| MRUS | New | MERUS N V | $1,608,000 | – | 76,992 | +100.0% | 0.12% | – |
| WIX | New | WIX COM LTD | $1,592,000 | – | 5,700 | +100.0% | 0.12% | – |
| KDNY | Sell | CHINOOK THERAPEUTICS INC | $1,580,000 | -50.6% | 101,666 | -49.6% | 0.12% | -57.4% |
| NSTB | New | NORTHERN STAR INVSTMNT CORP | $1,554,000 | – | 155,367 | +100.0% | 0.12% | – |
| IMCR | New | IMMUNOCORE HLDGS PLCads | $1,533,000 | – | 36,000 | +100.0% | 0.12% | – |
| TERN | New | TERNS PHARMACEUTICALS INC | $1,540,000 | – | 70,000 | +100.0% | 0.12% | – |
| LCAHU | New | LANDCADIA HOLDINGS IV INCunit 05/01/2025 | $1,485,000 | – | 150,000 | +100.0% | 0.11% | – |
| TWNIU | New | TAILWIND INTERNATNAL ACQ CORunit 99/99/9999 | $1,484,000 | – | 150,000 | +100.0% | 0.11% | – |
| KURIU | New | ALKURI GLOBAL ACQUISITION COunit 01/01/2028 | $1,482,000 | – | 150,000 | +100.0% | 0.11% | – |
| FMIVU | New | FORUM MERGER IV CORPunit 03/15/2028 | $1,485,000 | – | 150,000 | +100.0% | 0.11% | – |
| APSG | New | APOLLO STRATEGIC GROWTH CAPT | $1,485,000 | – | 150,000 | +100.0% | 0.11% | – |
| BBIO | Sell | BRIDGEBIO PHARMA INC | $1,472,000 | -86.9% | 23,890 | -84.9% | 0.11% | -88.7% |
| LRMR | New | LARIMAR THERAPEUTICS INC | $1,461,000 | – | 100,000 | +100.0% | 0.11% | – |
| GMDA | Buy | GAMIDA CELL LTD | $1,444,000 | +329.8% | 178,450 | +346.1% | 0.11% | +270.0% |
| PMVP | New | PMV PHARMACEUTICALS INC | $1,426,000 | – | 43,356 | +100.0% | 0.11% | – |
| FLAC | New | FRAZIER LIFESCIENCES ACQU CO | $1,261,000 | – | 126,687 | +100.0% | 0.10% | – |
| LFTR | New | LEFTERIS ACQUISITION CORP | $1,181,000 | – | 120,000 | +100.0% | 0.09% | – |
| VRTX | New | VERTEX PHARMACEUTICALS INC | $1,188,000 | – | 5,530 | +100.0% | 0.09% | – |
| RAAC | New | REVOLUTION ACCELERTN ACQU CO | $1,115,000 | – | 109,994 | +100.0% | 0.09% | – |
| HSAQ | HEALTH SCIENCES ACQ CORP 2 | $1,123,000 | -12.3% | 100,000 | 0.0% | 0.09% | -24.6% | |
| CAPA | New | HIGHCAPE CAP ACQUISITION CORcall | $1,013,000 | – | 85,000 | +100.0% | 0.08% | – |
| SWBK | New | SWITCHBACK II CORPORATION | $1,019,000 | – | 103,698 | +100.0% | 0.08% | – |
| OMEG | New | OMEGA ALPHA SPACcl a | $990,000 | – | 100,000 | +100.0% | 0.08% | – |
| MACQU | New | MCAP ACQUISITION CORPunit 02/18/2030 | $995,000 | – | 100,000 | +100.0% | 0.08% | – |
| VPCCU | New | VPC IMPACT ACQU HOLDI III INunit 99/99/9999 | $987,000 | – | 100,000 | +100.0% | 0.08% | – |
| VPCBU | New | VPC IMPACT ACQUISITION HLDGunit 03/05/2026 | $986,000 | – | 100,000 | +100.0% | 0.08% | – |
| FCAC | New | FALCON CAPITAL ACQUISITN COR | $997,000 | – | 100,010 | +100.0% | 0.08% | – |
| ENFAU | New | 890 5TH AVE PARTNERS INCunit 01/12/2026 | $983,000 | – | 98,828 | +100.0% | 0.08% | – |
| LCAP | New | LIONHEART ACQUISITION CORP I | $982,000 | – | 100,000 | +100.0% | 0.08% | – |
| ETAC | New | E MERGE TECHNOLOGY ACQUISITI | $975,000 | – | 100,000 | +100.0% | 0.08% | – |
| CNTB | New | CONNECT BIOPHARMA HLDGS LTDads | $925,000 | – | 50,000 | +100.0% | 0.07% | – |
| GLHAU | New | GLASS HOUSES ACQUISITION CORunit 03/25/2028 | $902,000 | – | 89,884 | +100.0% | 0.07% | – |
| NVMI | Sell | NOVA MEASURING INSTRUMENTS L | $779,000 | -85.9% | 8,556 | -89.0% | 0.06% | -87.7% |
| LOKMU | New | LIVE OAK MOBILITY ACQUISI COunit 03/01/2028 | $749,000 | – | 75,000 | +100.0% | 0.06% | – |
| CEREW | CEREVEL THERAPEUTICS HLDNG I*w exp 06/09/202 | $702,000 | -25.3% | 166,332 | 0.0% | 0.05% | -34.9% | |
| LABP | New | LANDOS BIOPHARMA INC | $674,000 | – | 70,000 | +100.0% | 0.05% | – |
| NICE SYS INCnote 1.250% 1/1 | $666,000 | -22.2% | 250,000 | 0.0% | 0.05% | -32.9% | ||
| SPRQ | New | SPARTAN ACQUISITION CORP II | $523,000 | – | 50,000 | +100.0% | 0.04% | – |
| VTIQU | New | VECTOIQ ACQUISITION CORP IIunit 99/99/9999 | $507,000 | – | 50,000 | +100.0% | 0.04% | – |
| EJFAU | New | EJF ACQUISITION CORPunit 03/10/2026 | $497,000 | – | 49,900 | +100.0% | 0.04% | – |
| AGGRU | New | AGILE GROWTH CORPunit 03/09/2026 | $496,000 | – | 50,000 | +100.0% | 0.04% | – |
| SCAQU | New | STRATIM CLOUD ACQUISITION COunit 03/05/2026 | $500,000 | – | 50,000 | +100.0% | 0.04% | – |
| ZWRKU | New | Z-WORK ACQUISITION CORPunit 99/99/9999 | $498,000 | – | 50,000 | +100.0% | 0.04% | – |
| MDHU | New | MDH ACQUISITION CORPunit 99/99/9999 | $308,000 | – | 31,000 | +100.0% | 0.02% | – |
| CMLF | New | CM LIFE SCIENCES INC | $298,000 | – | 20,000 | +100.0% | 0.02% | – |
| IMTXW | IMMATICS N.V*w exp 07/01/202 | $295,000 | +2.4% | 100,000 | 0.0% | 0.02% | -11.5% | |
| NRACU | New | NOBLE ROCK ACQUISITION CORPunit 01/31/2028 | $277,000 | – | 28,000 | +100.0% | 0.02% | – |
| FTEVU | New | FINTECH EVOLUTION ACQUIS GROunit 99/99/9999 | $247,000 | – | 25,000 | +100.0% | 0.02% | – |
| SRSA | New | SARISSA CAPITAL ACQUISITN COcl a | $242,000 | – | 23,900 | +100.0% | 0.02% | – |
| NBSE | New | NEUBASE THERAPEUTICS INC | $236,000 | – | 31,900 | +100.0% | 0.02% | – |
| OTLKW | OUTLOOK THERAPEUTICS INC*w exp 02/18/202 | $131,000 | +351.7% | 129,500 | 0.0% | 0.01% | +233.3% | |
| ORGS | Exit | ORGENESIS INC | $0 | – | -35,712 | -100.0% | -0.01% | – |
| CLRB | Exit | CELLECTAR BIOSCIENCES INC | $0 | – | -87,500 | -100.0% | -0.02% | – |
| MGEN | Exit | MIRAGEN THERAPEUTICS INC | $0 | – | -30,497 | -100.0% | -0.04% | – |
| OLMA | Exit | OLEMA PHARMACEUTICALS INC | $0 | – | -15,200 | -100.0% | -0.06% | – |
| SAGE | Exit | SAGE THERAPEUTICS INC | $0 | – | -8,554 | -100.0% | -0.07% | – |
| ACRS | Exit | ACLARIS THERAPEUTICS INC | $0 | – | -150,000 | -100.0% | -0.09% | – |
| KRON | Exit | KRONOS BIO INC | $0 | – | -35,000 | -100.0% | -0.09% | – |
| BTAI | Exit | BIOXCEL THERAPEUTICS INC | $0 | – | -28,093 | -100.0% | -0.12% | – |
| BCAB | Exit | BIOATLA INC | $0 | – | -50,000 | -100.0% | -0.15% | – |
| ETNB | Exit | 89BIO INC | $0 | – | -69,939 | -100.0% | -0.15% | – |
| IACA | Exit | ION ACQUISITION CORP 1 LTD | $0 | – | -150,000 | -100.0% | -0.16% | – |
| LPTX | Exit | LEAP THERAPEUTICS INC | $0 | – | -800,000 | -100.0% | -0.16% | – |
| ATHA | Exit | ATHIRA PHARMA INC | $0 | – | -53,900 | -100.0% | -0.16% | – |
| ALGS | Exit | ALIGOS THERAPEUTICS INC | $0 | – | -74,000 | -100.0% | -0.18% | – |
| WVE | Exit | WAVE LIFE SCIENCES LTD | $0 | – | -414,959 | -100.0% | -0.29% | – |
| ASND | Exit | ASCENDIS PHARMA A/Ssponsored adr | $0 | – | -23,599 | -100.0% | -0.35% | – |
| RCKT | Exit | ROCKET PHARMACEUTICALS INC | $0 | – | -75,000 | -100.0% | -0.36% | – |
| FROG | Exit | JFROG LTD | $0 | – | -72,377 | -100.0% | -0.40% | – |
| DRNA | Exit | DICERNA PHARMACEUTICALS INC | $0 | – | -216,980 | -100.0% | -0.42% | – |
| CNCE | Exit | CONCERT PHARMACEUTICALS INC | $0 | – | -384,039 | -100.0% | -0.43% | – |
| PRAX | Exit | PRAXIS PRECISION MEDICINES I | $0 | – | -100,000 | -100.0% | -0.49% | – |
| IOVA | Exit | IOVANCE BIOTHERAPEUTICS INC | $0 | – | -127,289 | -100.0% | -0.52% | – |
| DCPH | Exit | DECIPHERA PHARMACEUTICALS IN | $0 | – | -103,565 | -100.0% | -0.52% | – |
| KRYS | Exit | KRYSTAL BIOTECH INC | $0 | – | -101,044 | -100.0% | -0.54% | – |
| FOLD | Exit | AMICUS THERAPEUTICS INC | $0 | – | -265,753 | -100.0% | -0.54% | – |
| YMAB | Exit | Y-MABS THERAPEUTICS INC | $0 | – | -131,016 | -100.0% | -0.58% | – |
| BYSI | Exit | BEYONDSPRING INC | $0 | – | -598,000 | -100.0% | -0.65% | – |
| QURE | Exit | UNIQURE NV | $0 | – | -216,000 | -100.0% | -0.69% | – |
| VRNT | Exit | VERINT SYS INC | $0 | – | -127,000 | -100.0% | -0.76% | – |
| IMTX | Exit | IMMATICS N.V | $0 | – | -823,391 | -100.0% | -0.79% | – |
| AVRO | Exit | AVROBIO INC | $0 | – | -655,874 | -100.0% | -0.81% | – |
| BURL | Exit | BURLINGTON STORES INC | $0 | – | -35,000 | -100.0% | -0.81% | – |
| ALXN | Exit | ALEXION PHARMACEUTICALS INC | $0 | – | -60,000 | -100.0% | -0.83% | – |
| MRK | Exit | MERCK & CO. INCcall | $0 | – | -130,000 | -100.0% | -0.94% | – |
| FB | Exit | FACEBOOK INCcl a | $0 | – | -39,998 | -100.0% | -0.97% | – |
| NVS | Exit | NOVARTIS AGcall | $0 | – | -120,000 | -100.0% | -1.01% | – |
| ZYME | Exit | ZYMEWORKS INC | $0 | – | -245,000 | -100.0% | -1.03% | – |
| SRPT | Exit | SAREPTA THERAPEUTICS INC | $0 | – | -75,000 | -100.0% | -1.14% | – |
| SRPT | Exit | SAREPTA THERAPEUTICS INCput | $0 | – | -75,000 | -100.0% | -1.14% | – |
| ABBV | Exit | ABBVIE INCcall | $0 | – | -225,000 | -100.0% | -2.14% | – |
| NVS | Exit | NOVARTIS AGsponsored adr | $0 | – | -429,000 | -100.0% | -3.60% | – |
| XBI | Exit | SPDR SER TRput | $0 | – | -300,000 | -100.0% | -3.75% | – |
| SRPT | Exit | SAREPTA THERAPEUTICS INCcall | $0 | – | -370,000 | -100.0% | -5.60% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2021-05-17
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| TEVA PHARMACEUTICAL-SP ADR | 36 | Q3 2023 | 8.4% |
| MERCK & CO INC NEW | 35 | Q3 2023 | 8.4% |
| NICE Systems Ltd | 27 | Q3 2023 | 4.4% |
| BIOGEN INC | 26 | Q3 2023 | 6.7% |
| AMICUS THERAPEUTICS INC | 26 | Q2 2022 | 4.3% |
| PFIZER INC | 25 | Q3 2023 | 9.2% |
| SAREPTA THERAPEUTICS INC | 25 | Q3 2023 | 3.2% |
| JOHNSON & JOHNSON | 24 | Q3 2023 | 8.0% |
| UNIQURE NV | 23 | Q3 2023 | 1.2% |
| SYNDAX PHARMACEUTICALS INC | 22 | Q3 2023 | 3.9% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Cyclacel Pharmaceuticals, Inc. | February 06, 2023 | 250,000 | 2.0% |
| Altimmune, Inc. | February 14, 2022 | 1,244,241 | 3.1% |
| Allot Ltd. | February 16, 2021 | 1,129,054 | 3.2% |
| Larimar Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Neos Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Orgenesis Inc. | February 16, 2021 | 525,216 | 0.0% |
| Sio Gene Therapies Inc. | February 16, 2021 | ? | ? |
| X4 Pharmaceuticals, Inc | February 16, 2021 | 250,000 | 0.0% |
| Axovant Gene Therapies Ltd. | February 25, 2020 | 2,931,017 | 8.0% |
| Axovant Gene Therapies Ltd. | February 11, 2020 | 398,540 | 1.8% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 13F-HR/A | 2024-02-15 |
| 13F-HR | 2024-02-14 |
| SC 13G | 2024-02-08 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| 13F-HR | 2023-11-14 |
| SC 13G | 2023-10-10 |
| SC 13G | 2023-08-30 |
View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.