RTW INVESTMENTS, LP - Q4 2021 holdings

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$6.85 Billion is the total value of RTW INVESTMENTS, LP's 124 reported holdings in Q4 2021. The portfolio turnover from Q3 2021 to Q4 2021 was 25.0% .

All

			Value		Shares		↓ Weighting
SPY	Buy	SPDR S&P 500 ETF TRtr unit	$422,590,000	+12.8%	889,739	+1.9%	6.17%	+9.2%
RCKT		ROCKET PHARMACEUTICALS INC	$344,975,000	-26.5%	15,802,802	0.0%	5.04%	-28.9%
ALNY	Buy	ALNYLAM PHARMACEUTICALS INC	$335,070,000	+5.4%	1,975,879	+17.4%	4.89%	+2.1%
TMO	Buy	THERMO FISHER SCIENTIFIC INC	$290,583,000	+22.3%	435,500	+4.7%	4.24%	+18.4%
MASI	Buy	MASIMO CORP	$248,855,000	+10.4%	849,971	+2.1%	3.63%	+6.9%
MRTX	Buy	MIRATI THERAPEUTICS INC	$229,056,000	-13.3%	1,561,497	+4.6%	3.34%	-16.0%
PTCT		PTC THERAPEUTICS INC	$210,859,000	+7.0%	5,293,966	0.0%	3.08%	+3.6%
ILMN	Buy	ILLUMINA INC	$186,567,000	-4.7%	490,399	+1.6%	2.72%	-7.8%
PEN	Buy	PENUMBRA INC	$178,389,000	+73.8%	620,871	+61.2%	2.60%	+68.3%
VCEL		VERICEL CORP	$177,541,000	-19.5%	4,517,570	0.0%	2.59%	-22.0%
TNDM		TANDEM DIABETES CARE INC	$174,714,000	+26.1%	1,160,734	0.0%	2.55%	+22.1%
NTRA		NATERA INC	$173,914,000	-16.2%	1,862,234	0.0%	2.54%	-18.8%
ESTA		ESTABLISHMENT LABS HLDGS INC	$156,751,000	-5.6%	2,319,138	0.0%	2.29%	-8.5%
CLDX	Buy	CELLDEX THERAPEUTICS INC NEW	$151,530,000	-28.2%	3,921,579	+0.3%	2.21%	-30.5%
RXDX		PROMETHEUS BIOSCIENCES INC	$129,060,000	+66.8%	3,264,031	0.0%	1.88%	+61.5%
GMED		GLOBUS MED INCcl a	$120,633,000	-5.8%	1,670,811	0.0%	1.76%	-8.8%
CYTK	Buy	CYTOKINETICS INC	$116,739,000	+63.3%	2,561,182	+28.1%	1.70%	+58.2%
RARE	New	ULTRAGENYX PHARMACEUTICAL IN	$115,479,000	–	1,373,284	+100.0%	1.69%	–
RNA		AVIDITY BIOSCIENCES INC	$113,977,000	-3.5%	4,795,000	0.0%	1.66%	-6.6%
ISEE		IVERIC BIO INC	$112,402,000	+3.0%	6,722,624	0.0%	1.64%	-0.3%
ARGX	Buy	ARGENX SEsponsored adr	$111,167,000	+162.3%	317,447	+126.2%	1.62%	+154.0%
ITOS		ITEOS THERAPEUTICS INC	$109,556,000	+72.4%	2,353,015	0.0%	1.60%	+67.0%
TXG		10X GENOMICS INC	$109,408,000	+2.3%	734,481	0.0%	1.60%	-0.9%
AXNX		AXONICS INC	$108,856,000	-14.0%	1,943,864	0.0%	1.59%	-16.7%
APLS	New	APELLIS PHARMACEUTICALS INC	$94,106,000	–	1,990,404	+100.0%	1.37%	–
PTGX	Buy	PROTAGONIST THERAPEUTICS INC	$88,914,000	+186.1%	2,599,822	+48.2%	1.30%	+176.8%
STOK		STOKE THERAPEUTICS INC	$87,426,000	-5.7%	3,644,248	0.0%	1.28%	-8.7%
GH	Sell	GUARDANT HEALTH INC	$81,350,000	-29.7%	813,342	-12.1%	1.19%	-31.9%
CCCC		C4 THERAPEUTICS INC	$80,338,000	-27.9%	2,494,965	0.0%	1.17%	-30.2%
PMVP	Buy	PMV PHARMACEUTICALS INC	$68,860,000	+185.3%	2,980,960	+268.1%	1.01%	+176.4%
FULC	Buy	FULCRUM THERAPEUTICS INC	$68,405,000	-37.1%	3,866,872	+0.3%	1.00%	-39.1%
MGNX		MACROGENICS INC	$63,808,000	-23.4%	3,975,554	0.0%	0.93%	-25.7%
AXSM	Buy	AXSOME THERAPEUTICS INC	$61,159,000	+14.8%	1,618,819	+0.1%	0.89%	+11.1%
RGNX		REGENXBIO INC	$60,343,000	-22.0%	1,845,366	0.0%	0.88%	-24.5%
IDYA	Sell	IDEAYA BIOSCIENCES INC	$59,575,000	-28.4%	2,520,076	-22.8%	0.87%	-30.7%
CUTR	Buy	CUTERA INC	$57,727,000	-1.5%	1,397,063	+11.1%	0.84%	-4.6%
PRQR	Buy	PROQR THRAPEUTICS N V	$56,292,000	+4.4%	7,027,725	+9.1%	0.82%	+1.1%
BCYC	New	BICYCLE THERAPEUTICS PLCsponsored ads	$52,913,000	–	869,271	+100.0%	0.77%	–
ACET	New	ADICET BIO INC	$52,885,000	–	3,023,744	+100.0%	0.77%	–
SRPT	New	SAREPTA THERAPEUTICS INC	$52,433,000	–	582,265	+100.0%	0.77%	–
GHRS		GH RESEARCH PLCordinary shares	$50,602,000	+10.7%	2,168,957	0.0%	0.74%	+7.3%
	New	SCIENCE 37 HOLDINGS INC	$49,568,000	–	3,975,000	+100.0%	0.72%	–
	Buy	DERMTECH INC	$49,275,000	-50.8%	3,118,666	+0.0%	0.72%	-52.3%
RLMD	Buy	RELMADA THERAPEUTICS INC	$49,258,000	+22.2%	2,186,324	+42.2%	0.72%	+18.3%
BLU	Buy	BELLUS HEALTH INC NEW	$48,043,000	+57.9%	5,968,017	+20.1%	0.70%	+52.9%
		TENAYA THERAPEUTICS INC	$46,593,000	-4.1%	2,458,750	0.0%	0.68%	-7.2%
AVDL		AVADEL PHARMACEUTICALS PLCsponsored adr	$46,395,000	-17.6%	5,741,939	0.0%	0.68%	-20.3%
TARS		TARSUS PHARMACEUTICALS INC	$45,306,000	+4.4%	2,013,601	0.0%	0.66%	+1.2%
APYX		APYX MEDICAL CORPORATION	$43,566,000	-7.4%	3,398,279	0.0%	0.64%	-10.4%
IMCR		IMMUNOCORE HLDGS PLCads	$42,647,000	-7.6%	1,245,532	0.0%	0.62%	-10.5%
OM		OUTSET MED INC	$41,235,000	-6.8%	894,652	0.0%	0.60%	-9.7%
OYST	Buy	OYSTER PT PHARMA INC	$37,588,000	+70.4%	2,058,504	+10.6%	0.55%	+64.9%
EPIX		ESSA PHARMA INC	$37,448,000	+77.5%	2,637,192	0.0%	0.55%	+72.0%
LUNG		PULMONX CORP	$37,349,000	-10.9%	1,164,600	0.0%	0.54%	-13.8%
	New	VENTYX BIOSCIENCES INC	$30,818,000	–	1,551,778	+100.0%	0.45%	–
QTRX	New	QUANTERIX CORP	$29,106,000	–	686,470	+100.0%	0.42%	–
MIST		MILESTONE PHARMACEUTICALS IN	$28,264,000	+14.7%	4,315,102	0.0%	0.41%	+11.0%
CTMX	Buy	CYTOMX THERAPEUTICS INC	$26,109,000	+266.1%	6,029,700	+330.4%	0.38%	+252.8%
CSTL		CASTLE BIOSCIENCES INC	$25,680,000	-35.5%	599,009	0.0%	0.38%	-37.6%
NSTG	Sell	NANOSTRING TECHNOLOGIES INC	$25,508,000	-33.9%	604,029	-24.9%	0.37%	-36.1%
ATHA		ATHIRA PHARMA INC	$24,842,000	+38.9%	1,906,557	0.0%	0.36%	+34.4%
GLUE		MONTE ROSA THERAPEUTICS INC	$24,802,000	-4.6%	1,214,572	0.0%	0.36%	-7.7%
JNCE	Buy	JOUNCE THERAPEUTICS INC	$23,908,000	+130.5%	2,863,198	+105.1%	0.35%	+123.7%
	New	PYXIS ONCOLOGY INC	$23,265,000	–	2,120,760	+100.0%	0.34%	–
ARWR	New	ARROWHEAD PHARMACEUTICALS IN	$22,996,000	–	346,842	+100.0%	0.34%	–
CERE		CEREVEL THERAPEUTICS HLDNG I	$21,613,000	+9.9%	666,666	0.0%	0.32%	+6.4%
JNJ	Sell	JOHNSON & JOHNSON	$21,405,000	-22.3%	125,127	-26.6%	0.31%	-24.6%
	Sell	SIGHT SCIENCES INC	$20,801,000	-28.6%	1,183,871	-7.8%	0.30%	-30.9%
LABP		LANDOS BIOPHARMA INC	$20,523,000	-67.1%	4,275,722	0.0%	0.30%	-68.1%
	Buy	RENOVACOR INC	$20,386,000	+5.9%	2,647,540	+21.0%	0.30%	+2.8%
AGEN	Sell	AGENUS INC	$18,896,000	-60.3%	5,868,315	-35.3%	0.28%	-61.6%
OLK	Sell	OLINK HLDG ABsponsored ads	$18,531,000	-42.0%	1,018,188	-22.8%	0.27%	-43.8%
		AADI BIOSCIENCES INC	$18,468,000	-13.4%	764,701	0.0%	0.27%	-16.1%
TELA	Buy	TELA BIO INC	$17,916,000	-5.8%	1,399,686	+0.6%	0.26%	-8.7%
IMUX	Buy	IMMUNIC INC	$16,417,000	+35.3%	1,715,470	+25.1%	0.24%	+31.1%
ADVM	Buy	ADVERUM BIOTECHNOLOGIES INC	$13,296,000	-18.1%	7,554,817	+0.9%	0.19%	-20.8%
BWAY		BRAINSWAY LTDsponsored ads	$12,338,000	-4.5%	1,602,381	0.0%	0.18%	-7.7%
LJPC		LA JOLLA PHARMACEUTICAL CO	$10,825,000	+16.5%	2,327,903	0.0%	0.16%	+12.9%
NEO		NEOGENOMICS INC	$10,615,000	-28.6%	311,111	0.0%	0.16%	-30.8%
CLSD	Sell	CLEARSIDE BIOMEDICAL INC	$10,467,000	-58.5%	3,806,018	-9.5%	0.15%	-59.8%
OSUR	Sell	ORASURE TECHNOLOGIES INC	$10,032,000	-24.5%	1,154,380	-1.7%	0.15%	-27.0%
ABUS	Sell	ARBUTUS BIOPHARMA CORP	$9,742,000	-52.0%	2,504,493	-47.1%	0.14%	-53.6%
XGN		EXAGEN INC	$9,553,000	-14.5%	821,414	0.0%	0.14%	-17.3%
GTH	Sell	GENETRON HLDGS LTDads	$8,674,000	-62.5%	1,421,894	-15.0%	0.13%	-63.6%
URGN		UROGEN PHARMA LTD	$8,154,000	-43.5%	857,464	0.0%	0.12%	-45.4%
	New	ROIVANT SCIENCES LTD	$8,091,000	–	802,717	+100.0%	0.12%	–
		NYXOAH S A	$7,933,000	-21.4%	344,911	0.0%	0.12%	-23.7%
VINC	Sell	VINCERX PHARMA INC	$7,553,000	-37.7%	741,236	-1.2%	0.11%	-39.9%
MRUS	New	MERUS N V	$6,240,000	–	196,231	+100.0%	0.09%	–
RACB		RESEARCH ALLIANCE CORP II	$6,192,000	-1.3%	637,000	0.0%	0.09%	-5.3%
BLSA		BCLS ACQUISITION CORP	$6,003,000	-1.6%	612,500	0.0%	0.09%	-4.3%
NAUT		NAUTILUS BIOTECHNOLOGY INC	$5,698,000	-13.5%	1,100,000	0.0%	0.08%	-16.2%
SMIHU		SUMMIT HEALTHCRE ACQUISTN COunit 06/03/2026	$4,975,000	-1.0%	500,000	0.0%	0.07%	-3.9%
ARYD		ARYA SCIENCES ACQU CORP IVcl a	$4,958,000	-1.3%	500,000	0.0%	0.07%	-5.3%
		ARYA SCIENCES ACQUISITN CORP	$4,850,000	-1.8%	500,000	0.0%	0.07%	-4.1%
		PROCEPT BIOROBOTICS CORP	$4,855,000	-34.4%	194,136	0.0%	0.07%	-36.6%
IMTX		IMMATICS N.V	$4,704,000	+3.4%	350,000	0.0%	0.07%	0.0%
BMEA	Sell	BIOMEA FUSION INC	$4,424,000	-55.2%	593,846	-28.5%	0.06%	-56.4%
		SOPHIA GENETICS SAordinary shares	$4,230,000	-19.6%	300,000	0.0%	0.06%	-21.5%
FVAM		5 01 ACQUISITION CORP	$3,861,000	+0.3%	392,000	0.0%	0.06%	-3.4%
ASLN		ASLAN PHARMACEUTICALS LTDads	$3,640,000	-37.1%	3,250,000	0.0%	0.05%	-39.1%
	New	ISOPLEXIS CORP	$3,354,000	–	365,000	+100.0%	0.05%	–
MSAC		MEDICUS SCIENCES ACQUISITION	$2,907,000	-0.6%	300,000	0.0%	0.04%	-4.5%
		MAXCYTE INC	$2,802,000	-16.6%	275,000	0.0%	0.04%	-19.6%
PNT		POINT BIOPHARMA GLOBAL INC	$2,744,000	-27.2%	490,000	0.0%	0.04%	-29.8%
CNTB		CONNECT BIOPHARMA HLDGS LTDads	$2,318,000	-78.7%	450,000	0.0%	0.03%	-79.3%
DNAY		CODEX DNA INC	$2,160,000	-3.0%	200,000	0.0%	0.03%	-5.9%
APEN	New	APOLLO ENDOSURGERY INC	$2,175,000	–	258,064	+100.0%	0.03%	–
	Sell	TANGO THERAPEUTICS INC	$1,978,000	-74.5%	180,819	-69.9%	0.03%	-75.2%
	New	MINK THERAPEUTICS INC	$1,858,000	–	416,666	+100.0%	0.03%	–
MDXG		MIMEDX GROUP INC	$1,786,000	-0.3%	295,748	0.0%	0.03%	-3.7%
		SEMA4 HOLDINGS CORP	$1,784,000	-39.2%	400,000	0.0%	0.03%	-40.9%
		RXSIGHT INC	$1,688,000	-11.2%	150,000	0.0%	0.02%	-13.8%
AKYA		AKOYA BIOSCIENCES INC	$1,531,000	+9.7%	100,000	0.0%	0.02%	+4.8%
MIRO		MIROMATRIX MED INC	$1,313,000	-32.6%	280,000	0.0%	0.02%	-34.5%
RCEL	Sell	AVITA MEDICAL INC	$1,278,000	-74.2%	106,667	-61.9%	0.02%	-74.7%
OMIC		SINGULAR GENOMICS SYSTEMS IN	$1,156,000	+3.3%	100,000	0.0%	0.02%	0.0%
MASS		908 DEVICES INC	$1,035,000	-20.4%	40,000	0.0%	0.02%	-25.0%
	New	MINERVA SURGICAL INC	$853,000	–	166,000	+100.0%	0.01%	–
BOLT		BOLT BIOTHERAPEUTICS INC	$619,000	-61.3%	126,365	0.0%	0.01%	-62.5%
ZY		ZYMERGEN INC	$468,000	-49.2%	70,000	0.0%	0.01%	-50.0%
		RENOVACOR INC*w exp 99/99/999	$200,000	-10.7%	350,000	0.0%	0.00%	0.0%
ACHL	New	ACHILLES THERAPEUTICS PLCsponsored ads	$61,000	–	12,229	+100.0%	0.00%	–
MSACW		MEDICUS SCIENCES ACQUISITION*w exp 02/12/202	$24,000	0.0%	33,331	0.0%	0.00%	–
BNR	Exit	BURNING ROCK BIOTECH LTDsponsored ads	$0	–	-30,000	-100.0%	-0.01%	–
PROF	Exit	PROFOUND MED CORP	$0	–	-122,098	-100.0%	-0.03%	–
TWST	Exit	TWIST BIOSCIENCE CORP	$0	–	-18,473	-100.0%	-0.03%	–
CVRX	Exit	CVRX INC	$0	–	-150,000	-100.0%	-0.04%	–
MAAC	Exit	MONTES ARCHIMEDES ACQUISITIO	$0	–	-400,000	-100.0%	-0.05%	–
AFIB	Exit	ACUTUS MED INC	$0	–	-491,834	-100.0%	-0.07%	–
APVO	Exit	APTEVO THERAPEUTICS INC	$0	–	-281,402	-100.0%	-0.07%	–
BLI	Exit	BERKELEY LTS INC	$0	–	-257,546	-100.0%	-0.08%	–
SRRK	Exit	SCHOLAR ROCK HLDG CORP	$0	–	-161,612	-100.0%	-0.08%	–
HLXA	Exit	HELIX ACQUISITION CORP	$0	–	-750,000	-100.0%	-0.11%	–
LSAQ	Exit	LIFESCI ACQUISITION II CORP	$0	–	-975,000	-100.0%	-0.14%	–
INMD	Exit	INMODE LTD	$0	–	-124,999	-100.0%	-0.30%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-7,582,396	-100.0%	-2.30%	–

Other managers

Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):

Original filings

The following EDGAR filing(s) were analyzed to create this report:

View 13F-HR filed 2022-02-14

Signatures

The EDGAR filing(s) were signed by:

Roderick Wong — Managing Partner

Top long-term holdings

Name	Quarters owned	Latest quarter owned	Max weighting
ALNYLAM PHARMACEUTICALS INC	36	Q3 2023	19.7%
MASIMO CORP	32	Q3 2023	5.8%
LA JOLLA PHARMACEUTICAL CO	31	Q2 2022	9.7%
REGENXBIO INC	30	Q4 2022	10.8%
AGENUS INC	29	Q2 2022	9.0%
PTC THERAPEUTICS INC	28	Q3 2023	12.8%
DICERNA PHARMACEUTICALS INC	28	Q3 2021	10.8%
MIRATI THERAPEUTICS INC	26	Q3 2023	6.2%
ARGENX SE	26	Q3 2023	5.3%
VERICEL CORP	24	Q3 2023	3.9%

View RTW INVESTMENTS, LP's complete holdings history.

Latest significant ownerships (13-D/G)

RTW INVESTMENTS, LP Q4 2021 significant holdings filed using form 13D/G when ownership exceeds 5% of a company's total stock issue.
	Filed	Shares	Percentage
ROCKET PHARMACEUTICALS, INC.	September 19, 2023	18,188,457	-
ALLURION TECHNOLOGIES, INC.	August 11, 2023	3,457,707	7.4%
Orchestra BioMed Holdings, Inc.	May 05, 2023	5,620,645	15.7%
Renovacor, Inc.^{Sold out}	April 05, 2023	0	-
Adverum Biotechnologies, Inc.^{Sold out}	February 14, 2023	0	0.0%
Aptevo Therapeutics Inc.^{Sold out}	February 14, 2023	0	0.0%
ASLAN Pharmaceuticals Ltd^{Sold out}	February 14, 2023	0	0.0%
Athira Pharma, Inc.^{Sold out}	February 14, 2023	0	0.0%
BELLUS Health Inc.^{Sold out}	February 14, 2023	0	0.0%
Clearside Biomedical, Inc.^{Sold out}	February 14, 2023	0	0.0%

View RTW INVESTMENTS, LP's complete significant-ownership history.

Latest filings

Type	Filed
SC 13D/A	2024-04-17
SC 13D/A	2024-03-01
13F-HR	2024-02-14
SC 13G/A	2024-02-14
SC 13G/A	2024-02-14
SC 13G/A	2024-02-14
SC 13G/A	2024-02-14
SC 13G/A	2024-02-14
SC 13G/A	2024-02-14
SC 13G/A	2024-02-14

View RTW INVESTMENTS, LP's complete filings history.

All filings

View complete filings history.

Compare quarters

Issues

The following issues were detected while analyzing the report:

The reported total value is incorrect (6848326000.0 != 6848327000.0)

Export RTW INVESTMENTS, LP's holdings