$17.4 Billion is the total value of Baker Brothers Advisors's 118 reported holdings in Q1 2022. The portfolio turnover from Q4 2021 to Q1 2022 was 5.8% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| SGEN | Buy | Seagen Inc. | $6,757,712,000 | -6.8% | 46,912,266 | +0.0% | 38.83% | +10.1% |
| INCY | Buy | Incyte Corporation | $2,871,326,000 | +16.4% | 36,153,684 | +7.5% | 16.50% | +37.4% |
| BGNE | BeiGene, Ltd.sponsored adr | $2,200,754,000 | -30.4% | 11,668,897 | 0.0% | 12.64% | -17.8% | |
| ACAD | ACADIA Pharmaceuticals Inc. | $1,015,077,000 | +3.8% | 41,910,704 | 0.0% | 5.83% | +22.6% | |
| BMRN | BioMarin Pharmaceutical Inc. | $587,540,000 | -12.7% | 7,620,494 | 0.0% | 3.38% | +3.1% | |
| ASND | Ascendis Pharma A/Ssponsored adr | $533,003,000 | -12.8% | 4,541,604 | 0.0% | 3.06% | +3.0% | |
| ARGX | argenx SEsponsored adr | $353,008,000 | -10.0% | 1,119,557 | 0.0% | 2.03% | +6.3% | |
| BCRX | BioCryst Pharmaceuticals, Inc. | $206,678,000 | +17.4% | 12,710,818 | 0.0% | 1.19% | +38.6% | |
| MDGL | Madrigal Pharmaceuticals, Inc. | $147,103,000 | +15.8% | 1,499,213 | 0.0% | 0.84% | +36.7% | |
| KOD | Buy | Kodiak Sciences Inc. | $122,988,000 | -90.1% | 15,931,045 | +8.5% | 0.71% | -88.3% |
| MRTX | Mirati Therapeutics, Inc. | $115,912,000 | -43.9% | 1,409,784 | 0.0% | 0.67% | -33.8% | |
| GBT | Global Blood Therapeutics, Inc. | $114,823,000 | +18.3% | 3,314,765 | 0.0% | 0.66% | +39.8% | |
| ABCL | AbCellera Biologics Inc. | $101,889,000 | -31.8% | 10,450,180 | 0.0% | 0.58% | -19.5% | |
| KYMR | Kymera Therapeutics, Inc. | $100,922,000 | -33.3% | 2,384,742 | 0.0% | 0.58% | -21.3% | |
| HZNP | Buy | Horizon Therapeutics Public Ltd Co | $94,567,000 | +46.5% | 898,842 | +50.0% | 0.54% | +72.9% |
| TVTX | Buy | Travere Therapeutics, Inc. | $85,041,000 | +2.6% | 3,300,009 | +23.6% | 0.49% | +21.3% |
| IGMS | IGM Biosciences, Inc. | $84,363,000 | -8.9% | 3,156,102 | 0.0% | 0.48% | +7.8% | |
| NVTA | Invitae Corporation | $78,692,000 | -47.8% | 9,873,488 | 0.0% | 0.45% | -38.4% | |
| IMCR | Immunocore Holdings plcads | $75,370,000 | -12.7% | 2,520,730 | 0.0% | 0.43% | +3.1% | |
| CERS | Cerus Corporation | $75,285,000 | -19.4% | 13,713,195 | 0.0% | 0.43% | -4.6% | |
| LEGN | Sell | Legend Biotech Corporationsponsored ads | $73,007,000 | -37.1% | 2,008,999 | -19.3% | 0.42% | -25.7% |
| PRLD | Prelude Therapeutics Inc. | $69,854,000 | -44.6% | 10,123,824 | 0.0% | 0.40% | -34.6% | |
| AMRN | Amarin Corporation plcsponsored adr | $69,649,000 | -2.4% | 21,169,805 | 0.0% | 0.40% | +15.3% | |
| NBIX | Neurocrine Biosciences, Inc. | $63,466,000 | +10.1% | 676,975 | 0.0% | 0.36% | +29.9% | |
| MRUS | Merus N.V. | $53,871,000 | -16.9% | 2,037,469 | 0.0% | 0.31% | -1.6% | |
| KRYS | Krystal Biotech, Inc. | $53,747,000 | -4.9% | 807,735 | 0.0% | 0.31% | +12.4% | |
| INSM | Insmed Incorporated | $50,666,000 | -13.7% | 2,156,001 | 0.0% | 0.29% | +1.7% | |
| PACB | Pacific Biosciences of California, Inc. | $49,549,000 | -55.5% | 5,444,963 | 0.0% | 0.28% | -47.4% | |
| RYTM | Buy | Rhythm Pharmaceuticals, Inc. | $47,521,000 | +23.3% | 4,125,062 | +6.8% | 0.27% | +45.2% |
| HRTX | Heron Therapeutics, Inc. | $46,513,000 | -37.3% | 8,131,678 | 0.0% | 0.27% | -26.0% | |
| Entrada Therapeutics, Inc. | $44,174,000 | -45.2% | 4,704,419 | 0.0% | 0.25% | -35.2% | ||
| TIL | Instil Bio, Inc. | $41,857,000 | -37.2% | 3,893,700 | 0.0% | 0.24% | -25.6% | |
| ALKS | Alkermes plc | $39,465,000 | +13.1% | 1,500,000 | 0.0% | 0.23% | +33.5% | |
| Insmed Incorporatednote 0.75% 6/1/2028 | $38,614,000 | -10.9% | 40,000,000 | 0.0% | 0.22% | +5.2% | ||
| Sarepta Therapeutics, Inc.dbcv 1.5% 11/15/2024 | $38,359,000 | -10.2% | 29,174,000 | 0.0% | 0.22% | +5.8% | ||
| VSTM | Buy | Verastem, Inc. | $38,054,000 | -13.6% | 26,988,898 | +25.6% | 0.22% | +2.3% |
| KDNY | Chinook Therapeutics, Inc. | $38,186,000 | +0.3% | 2,334,102 | 0.0% | 0.22% | +18.4% | |
| AVTE | Buy | Aerovate Therapeutics, Inc. | $37,943,000 | +75.7% | 2,070,010 | +13.0% | 0.22% | +107.6% |
| IMTX | Immatics N.V. | $35,346,000 | -40.5% | 4,423,731 | 0.0% | 0.20% | -29.8% | |
| Buy | 2seventy bio, Inc. | $35,190,000 | +64.8% | 2,062,744 | +147.6% | 0.20% | +94.2% | |
| NRIX | Nurix Therapeutics, Inc. | $34,382,000 | -51.6% | 2,454,082 | 0.0% | 0.20% | -42.8% | |
| VERV | Verve Therapeutics, Inc. | $32,325,000 | -38.1% | 1,416,530 | 0.0% | 0.19% | -26.8% | |
| RARE | Ultragenyx Pharmaceutical Inc. | $32,276,000 | -13.6% | 444,444 | 0.0% | 0.18% | +1.6% | |
| KNSA | Kiniksa Pharmaceuticals, Ltd. | $27,828,000 | -15.5% | 2,799,577 | 0.0% | 0.16% | 0.0% | |
| REPL | Buy | Replimune Group, Inc. | $27,367,000 | +70.2% | 1,611,703 | +171.6% | 0.16% | +101.3% |
| AXSM | Axsome Therapeutics, Inc. | $25,288,000 | +9.6% | 610,970 | 0.0% | 0.14% | +29.5% | |
| DBVT | DBV Technologies S.A.sponsored adr | $23,237,000 | -0.6% | 14,614,264 | 0.0% | 0.13% | +17.5% | |
| DSGN | Design Therapeutics, Inc. | $23,202,000 | -24.6% | 1,436,636 | 0.0% | 0.13% | -11.3% | |
| XENE | Xenon Pharmaceuticals Inc. | $22,978,000 | -2.1% | 751,639 | 0.0% | 0.13% | +15.8% | |
| CCXI | Sell | ChemoCentryx, Inc. | $22,986,000 | -61.3% | 916,862 | -43.8% | 0.13% | -54.3% |
| AFMD | Buy | Affimed N.V. | $22,519,000 | +53.8% | 5,153,169 | +94.2% | 0.13% | +81.7% |
| ADAP | Adaptimmune Therapeutics plcsponsored adr | $20,252,000 | -45.1% | 9,830,877 | 0.0% | 0.12% | -35.2% | |
| OTIC | Otonomy, Inc. | $18,827,000 | +15.4% | 7,844,692 | 0.0% | 0.11% | +36.7% | |
| FMTX | Forma Therapeutics Holdings, Inc. | $18,831,000 | -34.6% | 2,024,876 | 0.0% | 0.11% | -22.9% | |
| OPT | Sell | Opthea Limitedsponsored ads | $18,485,000 | -23.3% | 2,696,191 | -15.6% | 0.11% | -9.4% |
| CRNX | Crinetics Pharmaceuticals, Inc. | $18,163,000 | -22.7% | 827,480 | 0.0% | 0.10% | -8.8% | |
| TCDA | Buy | Tricida, Inc. | $14,235,000 | +15.9% | 1,731,714 | +34.8% | 0.08% | +36.7% |
| RLMD | Relmada Therapeutics, Inc. | $13,363,000 | +19.8% | 495,113 | 0.0% | 0.08% | +42.6% | |
| FLGT | Fulgent Genetics, Inc. | $12,572,000 | -38.0% | 201,444 | 0.0% | 0.07% | -27.3% | |
| BLUE | bluebird bio, Inc. | $12,124,000 | -51.4% | 2,499,715 | 0.0% | 0.07% | -42.1% | |
| DICE Therapeutics, Inc. | $11,253,000 | -24.4% | 588,235 | 0.0% | 0.06% | -9.7% | ||
| ZYME | Zymeworks Inc. | $11,190,000 | -60.0% | 1,708,472 | 0.0% | 0.06% | -52.9% | |
| BCEL | Atreca, Inc. | $11,199,000 | +4.6% | 3,532,760 | 0.0% | 0.06% | +23.1% | |
| ATHA | Athira Pharma, Inc. | $10,886,000 | +3.6% | 806,367 | 0.0% | 0.06% | +23.5% | |
| TLIS | Talis Biomedical Corporation | $10,751,000 | -64.8% | 7,624,835 | 0.0% | 0.06% | -58.4% | |
| ANAB | AnaptysBio, Inc. | $10,568,000 | -28.8% | 427,179 | 0.0% | 0.06% | -15.3% | |
| CNTA | Centessa Pharmaceuticals plcsponsored ads | $10,112,000 | -20.3% | 1,127,273 | 0.0% | 0.06% | -6.5% | |
| SRPT | Sarepta Therapeutics, Inc. | $9,644,000 | -13.2% | 123,456 | 0.0% | 0.06% | +1.9% | |
| KRTX | Karuna Therapeutics, Inc. | $8,871,000 | -3.2% | 69,966 | 0.0% | 0.05% | +13.3% | |
| Invitae Corporationnote 2.0% 9/1/2024 | $8,379,000 | -12.9% | 10,300,000 | 0.0% | 0.05% | +2.1% | ||
| VERA | New | Vera Therapeutics, Inc.cl a | $7,830,000 | – | 333,333 | +100.0% | 0.04% | – |
| AGLE | Aeglea BioTherapeutics, Inc. | $7,843,000 | -51.6% | 3,410,106 | 0.0% | 0.04% | -43.0% | |
| ACHL | Achilles Therapeutics plcsponsored ads | $7,619,000 | -41.3% | 2,591,366 | 0.0% | 0.04% | -30.2% | |
| Surrozen, Inc. | $7,525,000 | -53.3% | 2,500,000 | 0.0% | 0.04% | -44.9% | ||
| RETA | Reata Pharmaceuticals, Inc.cl a | $7,337,000 | +24.2% | 223,976 | 0.0% | 0.04% | +44.8% | |
| NLTX | Neoleukin Therapeutics, Inc. | $7,185,000 | -61.0% | 3,821,740 | 0.0% | 0.04% | -54.4% | |
| BMEA | Buy | Biomea Fusion, Inc. | $6,919,000 | +77.0% | 1,551,445 | +195.7% | 0.04% | +110.5% |
| FGEN | Buy | FibroGen, Inc. | $6,993,000 | -14.5% | 581,750 | +0.3% | 0.04% | 0.0% |
| CBAY | CymaBay Therapeutics, Inc. | $6,750,000 | -8.0% | 2,170,464 | 0.0% | 0.04% | +8.3% | |
| ALT | Altimmune, Inc. | $6,529,000 | -33.5% | 1,072,038 | 0.0% | 0.04% | -20.8% | |
| HRMY | Harmony Biosciences Holdings, Inc. | $6,013,000 | +14.1% | 123,600 | 0.0% | 0.04% | +34.6% | |
| Tango Therapeutics, Inc. | $5,685,000 | -30.7% | 750,000 | 0.0% | 0.03% | -17.5% | ||
| RVMD | Revolution Medicines, Inc. | $5,669,000 | +1.4% | 222,222 | 0.0% | 0.03% | +22.2% | |
| HOOK | Buy | HOOKIPA Pharma Inc. | $5,473,000 | +235.4% | 2,400,481 | +242.7% | 0.03% | +287.5% |
| ITOS | Iteos Therapeutics, Inc. | $4,838,000 | -30.9% | 150,346 | 0.0% | 0.03% | -17.6% | |
| EWTX | Edgewise Therapeutics, Inc. | $4,850,000 | -36.5% | 500,000 | 0.0% | 0.03% | -24.3% | |
| NGM | NGM Biopharmaceuticals, Inc. | $4,450,000 | -13.9% | 291,801 | 0.0% | 0.03% | +4.0% | |
| ALGS | Aligos Therapeutics, Inc. | $4,464,000 | -81.9% | 2,076,400 | 0.0% | 0.03% | -78.3% | |
| KURA | Sell | Kura Oncology, Inc. | $4,413,000 | +3.6% | 274,458 | -9.8% | 0.02% | +19.0% |
| BCAB | BioAtla, Inc. | $4,125,000 | -74.5% | 825,000 | 0.0% | 0.02% | -69.6% | |
| TScan Therapeutics, Inc. | $3,990,000 | -37.8% | 1,425,000 | 0.0% | 0.02% | -25.8% | ||
| ALLK | Allakos Inc. | $4,007,000 | -41.8% | 703,050 | 0.0% | 0.02% | -30.3% | |
| MGNX | MacroGenics, Inc. | $3,899,000 | -45.1% | 442,579 | 0.0% | 0.02% | -37.1% | |
| ALEC | Alector, Inc. | $3,409,000 | -31.0% | 239,228 | 0.0% | 0.02% | -16.7% | |
| NVAX | Novavax, Inc. | $3,548,000 | -48.5% | 48,168 | 0.0% | 0.02% | -41.2% | |
| LIFE | aTyr Pharma, Inc. | $3,344,000 | -28.4% | 625,000 | 0.0% | 0.02% | -17.4% | |
| CYT | Cyteir Therapeutics, Inc. | $3,064,000 | -66.8% | 812,640 | 0.0% | 0.02% | -60.0% | |
| DNLI | Denali Therapeutics Inc. | $2,855,000 | -27.9% | 88,738 | 0.0% | 0.02% | -15.8% | |
| KZR | Kezar Life Sciences, Inc. | $2,321,000 | -0.6% | 139,676 | 0.0% | 0.01% | +18.2% | |
| TCRR | TCR2 Therapeutics Inc. | $2,078,000 | -40.8% | 753,064 | 0.0% | 0.01% | -29.4% | |
| SNDX | Syndax Pharmaceuticals, Inc. | $1,924,000 | -20.6% | 110,729 | 0.0% | 0.01% | -8.3% | |
| BNR | Burning Rock Biotech Limitedsponsored ads | $1,943,000 | -2.5% | 209,131 | 0.0% | 0.01% | +10.0% | |
| AKRO | Akero Therapeutics, Inc. | $1,680,000 | -32.9% | 118,378 | 0.0% | 0.01% | -16.7% | |
| CABA | Cabaletta Bio, Inc. | $1,344,000 | -46.4% | 662,063 | 0.0% | 0.01% | -33.3% | |
| EPZM | New | Epizyme, Inc. | $1,150,000 | – | 1,000,000 | +100.0% | 0.01% | – |
| NEXI | NexImmune, Inc. | $1,238,000 | -8.7% | 294,117 | 0.0% | 0.01% | 0.0% | |
| TARA | Protara Therapeutics, Inc. | $1,020,000 | -24.3% | 199,671 | 0.0% | 0.01% | -14.3% | |
| GTH | Genetron Holdings Limitedads | $997,000 | -64.1% | 455,306 | 0.0% | 0.01% | -57.1% | |
| VINC | Vincerx Pharma, Inc. | $966,000 | -60.7% | 241,379 | 0.0% | 0.01% | -50.0% | |
| LPTX | Leap Therapeutics, Inc. | $979,000 | -46.0% | 559,705 | 0.0% | 0.01% | -33.3% | |
| OYST | Oyster Point Pharma, Inc. | $715,000 | -36.3% | 61,424 | 0.0% | 0.00% | -20.0% | |
| Sera Prognostics, Inc. | $764,000 | -44.8% | 201,562 | 0.0% | 0.00% | -42.9% | ||
| FHTX | Foghorn Therapeutics Inc. | $686,000 | -33.4% | 45,027 | 0.0% | 0.00% | -20.0% | |
| INZY | Inozyme Pharma, Inc. | $438,000 | -40.0% | 106,999 | 0.0% | 0.00% | -25.0% | |
| Bellicum Pharmaceuticals, Inc. | $538,000 | +45.0% | 249,123 | 0.0% | 0.00% | +50.0% | ||
| PASG | Passage Bio, Inc. | $363,000 | -51.2% | 117,161 | 0.0% | 0.00% | -50.0% | |
| LOGC | LogicBio Therapeutics, Inc. | $307,000 | -70.6% | 451,478 | 0.0% | 0.00% | -60.0% | |
| Surrozen, Inc.w exp 8/11/2026 | $208,000 | -78.3% | 833,333 | 0.0% | 0.00% | -80.0% | ||
| EVFM | Exit | Evofem Biosciences, Inc. | $0 | – | -2,697,110 | -100.0% | -0.01% | – |
| GMDA | Exit | Gamida Cell Ltd. | $0 | – | -610,626 | -100.0% | -0.01% | – |
| ALBO | Exit | Albireo Pharma, Inc. | $0 | – | -104,521 | -100.0% | -0.01% | – |
| Exit | Tricida, Inc.note 3.5% 5/15/2027 | $0 | – | -27,500,000 | -100.0% | -0.07% | – | |
| Exit | Apellis Pharmaceuticals, Inc.note 3.5% 9/15/2026 | $0 | – | -31,754,000 | -100.0% | -0.23% | – |
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2022-05-16
About Baker Brothers Advisors
Baker Brothers Advisors is a well-known investment management firm that specializes in the healthcare sector. The firm was founded in 2000 by brothers Julian and Felix Baker, who are both highly respected in the industry. Julian Baker is the CEO of the firm, while Felix Baker serves as a managing partner.
Baker Brothers Advisors has a reputation for investing in innovative healthcare companies that have the potential to make a significant impact on the industry. The firm has a long-term investment approach and is known for taking large positions in companies that it believes in. Some of the firm's most successful investments include companies such as Pharmacyclics, which was acquired by AbbVie for $21 billion, and Ariad Pharmaceuticals, which was acquired by Takeda for $5.2 billion.
The firm's investment strategy is led by its Chief Investment Officer, Dr. Robert Duggan, who has a background in both medicine and finance. Dr. Duggan is known for his ability to identify promising healthcare companies and for his willingness to take risks on early-stage companies.
Overall, Baker Brothers Advisors is a highly respected investment management firm that has a proven track record of success in the healthcare sector. While the firm's investment approach may not be suitable for all investors, those who are interested in the healthcare sector may want to consider Baker Brothers Advisors as a potential investment opportunity.
It's important to note that this information is for educational purposes only and has not been fact-checked. As with any investment, it's important to do your own research and consult with a financial advisor before making any investment decisions.
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| Incyte Corporation | 42 | Q3 2023 | 37.6% |
| ACADIA Pharmaceuticals Inc. | 42 | Q3 2023 | 10.9% |
| Biomarin Pharmaceuticals Inc. | 42 | Q3 2023 | 5.9% |
| BioCryst Pharmaceuticals, Inc. | 42 | Q3 2023 | 1.7% |
| Cerus Corporation | 42 | Q3 2023 | 0.9% |
| Insmed Incorporated | 42 | Q3 2023 | 0.4% |
| Mirati Therapeutics, Inc. | 41 | Q3 2023 | 1.8% |
| Bluebird Bio Inc. | 41 | Q3 2023 | 0.3% |
| Heron Therapeutics, Inc. | 39 | Q3 2023 | 1.5% |
| ChemoCentryx, Inc. | 37 | Q3 2022 | 0.6% |
View Baker Brothers Advisors's complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Neoleukin Therapeutics, Inc. | August 17, 2023 | 9,469,838 | 20.0% |
| Mereo Biopharma Group plc | August 10, 2023 | 14,604,391 | 2.2% |
| Verastem, Inc. | August 10, 2023 | ? | ? |
| TScan Therapeutics, Inc. | June 02, 2023 | 2,793,938 | 6.5% |
| ACADIA PHARMACEUTICALS INC | May 24, 2023 | 43,084,280 | 26.5% |
| INCYTE CORP | March 15, 2023 | 36,280,967 | 16.3% |
| Seagen Inc. | March 13, 2023 | 46,985,656 | 25.1% |
| Talis Biomedical Corp | March 10, 2023 | 37,569,140 | 66.2% |
| Aeglea BioTherapeutics, Inc. | February 14, 2023 | 6,384,013 | 9.9% |
| Merus N.V. | February 14, 2023 | ? | ? |
View Baker Brothers Advisors's complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 4 | 2024-04-23 |
| SC 13D/A | 2024-04-23 |
| 4 | 2024-04-22 |
| 3 | 2024-04-18 |
| SC 13D | 2024-04-18 |
| 3 | 2024-04-01 |
| 4 | 2024-04-01 |
| 4 | 2024-04-01 |
| 4 | 2024-04-01 |
| SC 13D | 2024-04-01 |
View Baker Brothers Advisors's complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.