Baker Brothers Advisors Q4 2021 holdings

$20.6 Billion is the total value of Baker Brothers Advisors's 121 reported holdings in Q4 2021. The portfolio turnover from Q3 2021 to Q4 2021 was 9.0% .

 Value Shares↓ Weighting
SGEN SellSeagen Inc.$7,249,714
-9.7%
46,893,364
-0.8%
35.27%
+0.0%
BGNE  BeiGene, Ltd.sponsored adr$3,161,454
-25.4%
11,668,8970.0%15.38%
-17.3%
INCY BuyIncyte Corporation$2,467,566
+12.0%
33,618,063
+5.0%
12.01%
+24.1%
KOD  Kodiak Sciences Inc.$1,244,681
-11.7%
14,681,3040.0%6.06%
-2.1%
ACAD  ACADIA Pharmaceuticals Inc.$978,196
+40.5%
41,910,7040.0%4.76%
+55.7%
BMRN  BioMarin Pharmaceutical Inc.$673,271
+14.3%
7,620,4940.0%3.28%
+26.7%
ASND  Ascendis Pharma A/Ssponsored adr$610,982
-15.6%
4,541,6040.0%2.97%
-6.5%
ARGX  argenx SEsponsored adr$392,058
+16.0%
1,119,5570.0%1.91%
+28.4%
MRTX  Mirati Therapeutics, Inc.$206,801
-17.1%
1,409,7840.0%1.01%
-8.1%
BCRX  BioCryst Pharmaceuticals, Inc.$176,045
-3.6%
12,710,8180.0%0.86%
+6.9%
KYMR  Kymera Therapeutics, Inc.$151,407
+8.1%
2,384,7420.0%0.74%
+19.8%
NVTA  Invitae Corporation$150,768
-46.3%
9,873,4880.0%0.73%
-40.5%
ABCL  AbCellera Biologics Inc.$149,438
-28.6%
10,450,1800.0%0.73%
-21.0%
MDGL  Madrigal Pharmaceuticals, Inc.$127,043
+6.2%
1,499,2130.0%0.62%
+17.7%
PRLD  Prelude Therapeutics Inc.$126,042
-60.2%
10,123,8240.0%0.61%
-55.9%
LEGN BuyLegend Biotech Corporationsponsored ads$116,012
-2.9%
2,489,003
+5.3%
0.56%
+7.4%
PACB  Pacific Biosciences of California, Inc.$111,404
-19.9%
5,444,9630.0%0.54%
-11.3%
GBT BuyGlobal Blood Therapeutics, Inc.$97,023
+18.3%
3,314,765
+3.0%
0.47%
+31.1%
CERS  Cerus Corporation$93,387
+11.8%
13,713,1950.0%0.45%
+23.7%
IGMS  IGM Biosciences, Inc.$92,568
-55.4%
3,156,1020.0%0.45%
-50.6%
IMCR  Immunocore Holdings plcads$86,310
-7.6%
2,520,7300.0%0.42%
+2.4%
TVTX BuyTravere Therapeutics, Inc.$82,847
+67.5%
2,669,054
+30.9%
0.40%
+85.7%
NewEntrada Therapeutics, Inc.$80,5404,704,419
+100.0%
0.39%
HRTX  Heron Therapeutics, Inc.$74,242
-14.6%
8,131,6780.0%0.36%
-5.5%
AMRN SellAmarin Corporation plcsponsored adr$71,342
-36.0%
21,169,805
-3.1%
0.35%
-29.0%
NRIX  Nurix Therapeutics, Inc.$71,046
-3.4%
2,454,0820.0%0.35%
+7.1%
TIL  Instil Bio, Inc.$66,621
-4.3%
3,893,7000.0%0.32%
+5.9%
MRUS  Merus N.V.$64,792
+44.5%
2,037,4690.0%0.32%
+59.9%
HZNP  Horizon Therapeutics Public Ltd Co$64,560
-1.6%
599,1100.0%0.31%
+9.0%
CCXI BuyChemoCentryx, Inc.$59,394
+1053.3%
1,631,266
+441.6%
0.29%
+1156.5%
IMTX  Immatics N.V.$59,455
+3.4%
4,423,7310.0%0.29%
+14.2%
INSM  Insmed Incorporated$58,729
-1.1%
2,156,0010.0%0.29%
+9.6%
NBIX  Neurocrine Biosciences, Inc.$57,658
-11.2%
676,9750.0%0.28%
-1.4%
KRYS BuyKrystal Biotech, Inc.$56,501
+78.1%
807,735
+32.9%
0.28%
+97.8%
VERV  Verve Therapeutics, Inc.$52,227
-21.6%
1,416,5300.0%0.25%
-13.0%
SellApellis Pharmaceuticals, Inc.note 3.5% 9/15/2026$47,968
-16.2%
31,754,000
-32.1%
0.23%
-7.2%
VSTM  Verastem, Inc.$44,058
-33.4%
21,491,6300.0%0.21%
-26.5%
 Insmed Incorporatednote 0.75% 6/1/2028$43,336
-1.1%
40,000,0000.0%0.21%
+9.3%
 Sarepta Therapeutics, Inc.dbcv 1.5% 11/15/2024$42,695
-1.1%
29,174,0000.0%0.21%
+9.5%
RYTM  Rhythm Pharmaceuticals, Inc.$38,555
-23.6%
3,863,2390.0%0.19%
-15.3%
KDNY BuyChinook Therapeutics, Inc.$38,069
+56.8%
2,334,102
+22.6%
0.18%
+72.9%
RARE  Ultragenyx Pharmaceutical Inc.$37,373
-6.8%
444,4440.0%0.18%
+3.4%
ADAP  Adaptimmune Therapeutics plcsponsored adr$36,866
-27.5%
9,830,8770.0%0.18%
-19.7%
ALKS BuyAlkermes plc$34,890
-7.9%
1,500,000
+22.1%
0.17%
+2.4%
KNSA  Kiniksa Pharmaceuticals, Ltd.$32,951
+3.3%
2,799,5770.0%0.16%
+14.3%
DSGN  Design Therapeutics, Inc.$30,758
+45.7%
1,436,6360.0%0.15%
+61.3%
TLIS BuyTalis Biomedical Corporation$30,576
-35.4%
7,624,835
+0.7%
0.15%
-28.4%
FMTX  Forma Therapeutics Holdings, Inc.$28,794
-38.7%
2,024,8760.0%0.14%
-32.0%
ZYME  Zymeworks Inc.$28,002
-43.6%
1,708,4720.0%0.14%
-37.6%
BLUE  bluebird bio, Inc.$24,972
-47.7%
2,499,7150.0%0.12%
-42.4%
ALGS  Aligos Therapeutics, Inc.$24,647
-23.5%
2,076,4000.0%0.12%
-14.9%
OPT SellOpthea Limitedsponsored ads$24,115
-10.9%
3,196,191
-5.5%
0.12%
-1.7%
CRNX SellCrinetics Pharmaceuticals, Inc.$23,509
+21.3%
827,480
-10.1%
0.11%
+34.1%
XENE  Xenon Pharmaceuticals Inc.$23,481
+104.4%
751,6390.0%0.11%
+128.0%
DBVT  DBV Technologies S.A.sponsored adr$23,383
-67.3%
14,614,2640.0%0.11%
-63.7%
AXSM BuyAxsome Therapeutics, Inc.$23,082
+29.9%
610,970
+13.3%
0.11%
+43.6%
AVTE BuyAerovate Therapeutics, Inc.$21,597
-37.7%
1,831,789
+10.9%
0.10%
-30.9%
New2seventy bio, Inc.$21,356833,236
+100.0%
0.10%
FLGT SellFulgent Genetics, Inc.$20,263
-43.8%
201,444
-49.8%
0.10%
-37.3%
NLTX  Neoleukin Therapeutics, Inc.$18,421
-33.3%
3,821,7400.0%0.09%
-25.6%
OTIC BuyOtonomy, Inc.$16,317
+10.5%
7,844,692
+2.0%
0.08%
+21.5%
AGLE  Aeglea BioTherapeutics, Inc.$16,198
-40.3%
3,410,1060.0%0.08%
-33.6%
BCAB  BioAtla, Inc.$16,195
-33.3%
825,0000.0%0.08%
-26.2%
REPL BuyReplimune Group, Inc.$16,081
+253.4%
593,395
+286.5%
0.08%
+290.0%
 Surrozen, Inc.$16,100
-9.0%
2,500,0000.0%0.08%0.0%
SellTricida, Inc.note 3.5% 5/15/2027$14,828
-52.7%
27,500,000
-63.3%
0.07%
-47.8%
ANAB  AnaptysBio, Inc.$14,844
+28.1%
427,1790.0%0.07%
+41.2%
 DICE Therapeutics, Inc.$14,888
-22.7%
588,2350.0%0.07%
-15.3%
AFMD BuyAffimed N.V.$14,645
+1340.0%
2,653,169
+1511.8%
0.07%
+1675.0%
ACHL  Achilles Therapeutics plcsponsored ads$12,983
-35.7%
2,591,3660.0%0.06%
-29.2%
CNTA  Centessa Pharmaceuticals plcsponsored ads$12,693
-32.6%
1,127,2730.0%0.06%
-25.3%
TCDA BuyTricida, Inc.$12,285
+155.2%
1,285,014
+23.9%
0.06%
+185.7%
SRPT NewSarepta Therapeutics, Inc.$11,117123,456
+100.0%
0.05%
RLMD BuyRelmada Therapeutics, Inc.$11,155
+111.8%
495,113
+146.3%
0.05%
+134.8%
BCEL  Atreca, Inc.$10,704
-51.4%
3,532,7600.0%0.05%
-46.4%
ATHA  Athira Pharma, Inc.$10,507
+38.9%
806,3670.0%0.05%
+54.5%
ALT  Altimmune, Inc.$9,820
-19.0%
1,072,0380.0%0.05%
-9.4%
 Invitae Corporationnote 2.0% 9/1/2024$9,623
-23.4%
10,300,0000.0%0.05%
-14.5%
KRTX  Karuna Therapeutics, Inc.$9,166
+7.1%
69,9660.0%0.04%
+18.4%
CYT  Cyteir Therapeutics, Inc.$9,240
-35.2%
812,6400.0%0.04%
-28.6%
FGEN NewFibroGen, Inc.$8,180580,150
+100.0%
0.04%
 Tango Therapeutics, Inc.$8,205
-15.4%
750,0000.0%0.04%
-7.0%
EWTX  Edgewise Therapeutics, Inc.$7,640
-8.0%
500,0000.0%0.04%
+2.8%
CBAY  CymaBay Therapeutics, Inc.$7,336
-7.4%
2,170,4640.0%0.04%
+2.9%
MGNX  MacroGenics, Inc.$7,103
-23.4%
442,5790.0%0.04%
-14.6%
NVAX SellNovavax, Inc.$6,891
-69.4%
48,168
-55.7%
0.03%
-65.7%
ITOS  Iteos Therapeutics, Inc.$7,000
+72.5%
150,3460.0%0.03%
+88.9%
ALLK  Allakos Inc.$6,883
-90.8%
703,0500.0%0.03%
-89.9%
 TScan Therapeutics, Inc.$6,413
-46.0%
1,425,0000.0%0.03%
-40.4%
RETA  Reata Pharmaceuticals, Inc.cl a$5,906
-73.8%
223,9760.0%0.03%
-70.7%
RVMD  Revolution Medicines, Inc.$5,593
-8.5%
222,2220.0%0.03%0.0%
HRMY  Harmony Biosciences Holdings, Inc.$5,270
+11.2%
123,6000.0%0.03%
+23.8%
NGM  NGM Biopharmaceuticals, Inc.$5,168
-15.7%
291,8010.0%0.02%
-7.4%
ALEC  Alector, Inc.$4,940
-9.5%
239,2280.0%0.02%0.0%
LIFE  aTyr Pharma, Inc.$4,669
-17.7%
625,0000.0%0.02%
-8.0%
KURA  Kura Oncology, Inc.$4,258
-25.3%
304,1580.0%0.02%
-16.0%
BMEA  Biomea Fusion, Inc.$3,908
-37.8%
524,6170.0%0.02%
-32.1%
DNLI  Denali Therapeutics Inc.$3,958
-11.6%
88,7380.0%0.02%
-5.0%
TCRR BuyTCR2 Therapeutics Inc.$3,509
+133.6%
753,064
+326.8%
0.02%
+142.9%
GTH  Genetron Holdings Limitedads$2,777
-56.0%
455,3060.0%0.01%
-50.0%
ALBO SellAlbireo Pharma, Inc.$2,434
-81.1%
104,521
-74.7%
0.01%
-78.9%
AKRO  Akero Therapeutics, Inc.$2,504
-5.4%
118,3780.0%0.01%0.0%
SNDX  Syndax Pharmaceuticals, Inc.$2,424
+14.6%
110,7290.0%0.01%
+33.3%
VINC  Vincerx Pharma, Inc.$2,460
-37.0%
241,3790.0%0.01%
-29.4%
CABA  Cabaletta Bio, Inc.$2,509
-68.8%
662,0630.0%0.01%
-65.7%
KZR  Kezar Life Sciences, Inc.$2,335
+93.5%
139,6760.0%0.01%
+120.0%
BNR  Burning Rock Biotech Limitedsponsored ads$1,993
-46.7%
209,1310.0%0.01%
-37.5%
LPTX  Leap Therapeutics, Inc.$1,813
-19.2%
559,7050.0%0.01%
-10.0%
HOOK  HOOKIPA Pharma Inc.$1,632
-60.4%
700,4810.0%0.01%
-55.6%
GMDA  Gamida Cell Ltd.$1,551
-35.2%
610,6260.0%0.01%
-27.3%
TARA  Protara Therapeutics, Inc.$1,348
-2.5%
199,6710.0%0.01%
+16.7%
NEXI  NexImmune, Inc.$1,356
-69.5%
294,1170.0%0.01%
-65.0%
 Sera Prognostics, Inc.$1,385
-38.1%
201,5620.0%0.01%
-30.0%
FHTX NewFoghorn Therapeutics Inc.$1,03045,027
+100.0%
0.01%
 Surrozen, Inc.w exp 8/11/2026$958
+0.8%
833,3330.0%0.01%
+25.0%
OYST  Oyster Point Pharma, Inc.$1,122
+54.1%
61,4240.0%0.01%
+66.7%
LOGC  LogicBio Therapeutics, Inc.$1,043
-49.6%
451,4780.0%0.01%
-44.4%
EVFM  Evofem Biosciences, Inc.$1,013
-49.1%
2,697,1100.0%0.01%
-44.4%
INZY  Inozyme Pharma, Inc.$730
-41.1%
106,9990.0%0.00%
-20.0%
PASG  Passage Bio, Inc.$744
-36.2%
117,1610.0%0.00%
-20.0%
 Bellicum Pharmaceuticals, Inc.$371
-49.0%
249,1230.0%0.00%
-33.3%
MREO ExitMereo BioPharma Group plcads$0-292,692
-100.0%
-0.00%
XLRN ExitAcceleron Pharma Inc.$0-22,430
-100.0%
-0.02%
ExitBioMarin Pharmaceutical Inc.note 0.599% 8/1/2024$0-4,500,000
-100.0%
-0.02%
AMYT ExitAmryt Pharma plcsponsored adr$0-518,380
-100.0%
-0.03%
AUPH ExitAurinia Pharmaceuticals Inc.$0-520,523
-100.0%
-0.05%
MIRM ExitMirum Pharmaceuticals, Inc.$0-647,313
-100.0%
-0.06%
Signed by
  • Alexandra Toohey — Chief Financial Officer

Compare quarterly holdings

Export Baker Brothers Advisors's holdings

EDGAR filings