Baker Brothers Advisors - Q2 2016 holdings

$9.54 Billion is the total value of Baker Brothers Advisors's 135 reported holdings in Q2 2016. The portfolio turnover from Q1 2016 to Q2 2016 was 15.7% .

 Value Shares↓ Weighting
INCY BuyIncyte Corporation$1,879,426,000
+10.4%
23,498,697
+0.0%
19.70%
+9.7%
SGEN BuySeattle Genetics, Inc.$1,747,287,000
+15.2%
43,238,967
+0.0%
18.32%
+14.5%
ABBV  AbbVie Inc.$889,866,000
+8.4%
14,373,5380.0%9.33%
+7.7%
ACAD BuyACADIA Pharmaceuticals Inc.$795,813,000
+17.5%
24,516,738
+1.3%
8.34%
+16.9%
ALXN BuyAlexion Pharmaceuticals, Inc.$763,995,000
-16.1%
6,543,295
+0.0%
8.01%
-16.6%
 Incyte Corporation Notes 1.25% 11/15/2020 144Anote 1.25% 11/15/2020$467,293,000
+8.1%
274,500,0000.0%4.90%
+7.5%
 Incyte Corporation Notes 0.375% 11/15/2018 144Anote 0.375% 11/15/2018$431,835,000
+8.5%
259,000,0000.0%4.53%
+7.9%
BMRN  BioMarin Pharmaceutical Inc.$373,944,000
-5.7%
4,806,4830.0%3.92%
-6.2%
GHDX BuyGenomic Health, Inc.$353,955,000
+4.6%
13,668,866
+0.1%
3.71%
+4.0%
DBVT  DBV Technologies S.A.sponsored adr$179,722,000
+0.2%
5,509,5600.0%1.88%
-0.4%
 XenoPort, Inc. Notes 2.5% 2/1/2022note 2.5% 2/1/2022$98,471,000
+34.1%
100,000,0000.0%1.03%
+33.3%
ACOR  Acorda Therapeutics, Inc.$93,376,000
-3.6%
3,661,0820.0%0.98%
-4.1%
 BioMarin Pharmaceutical Inc. Notes 1.875% 4/23/2017note 1.875% 4/23/2017$84,908,000
-5.5%
22,379,0000.0%0.89%
-6.0%
CERS  Cerus Corporation$84,572,000
+5.2%
13,553,2750.0%0.89%
+4.6%
ONCE BuySpark Therapeutics, Inc.$67,407,000
+80.9%
1,318,341
+4.4%
0.71%
+79.9%
 Acorda Therapeutics, Inc. Notes 1.75% 6/15/2021note 1.75% 6/15/2021$67,351,000
-1.6%
77,083,0000.0%0.71%
-2.2%
BLCM  Bellicum Pharmaceuticals, Inc.$63,059,000
+38.6%
4,865,6470.0%0.66%
+37.7%
BGNE  BeiGene, Ltd.sponsored adr$56,998,000
+1.7%
1,912,6800.0%0.60%
+1.2%
HRTX SellHeron Therapeutics, Inc.$51,573,000
-6.6%
2,857,250
-1.7%
0.54%
-7.0%
AQXP  Aquinox Pharmaceuticals, Inc.$51,321,000
-24.9%
7,752,4870.0%0.54%
-25.4%
SellClovis Oncology, Inc. 2.5% 9/15/2021note 2.5% 9/15/2021$51,310,000
-41.6%
72,758,000
-43.7%
0.54%
-41.9%
NVTA  Invitae Corporation$48,441,000
-27.8%
6,554,9670.0%0.51%
-28.1%
BCRX  BioCryst Pharmaceuticals, Inc.$42,630,000
+0.4%
15,010,5340.0%0.45%
-0.2%
NBIX  Neurocrine Biosciences, Inc.$40,697,000
+14.9%
895,4220.0%0.43%
+14.5%
VSAR SellVersartis, Inc.$30,121,000
+17.4%
2,723,399
-14.9%
0.32%
+16.6%
 Exelixis, Inc. Notes 4.25% 8/15/2019note 4.25% 8/15/2019$29,654,000
+50.0%
20,000,0000.0%0.31%
+48.8%
AAAP BuyAdvanced Accelerator Applications S.A.sponsored adr$25,188,000
+16.9%
833,089
+35.5%
0.26%
+16.3%
XNPT  XenoPort, Inc.$24,469,000
+56.1%
3,475,6720.0%0.26%
+55.8%
ITCI  Intra-Cellular Therapies, Inc.$23,648,000
+39.6%
609,1660.0%0.25%
+38.5%
SGMO  Sangamo BioSciences, Inc.$23,484,000
-4.3%
4,055,8760.0%0.25%
-5.0%
NTLA NewIntellia Therapeutics, Inc.$22,676,0001,062,120
+100.0%
0.24%
EXEL  Exelixis, Inc.$20,150,000
+95.3%
2,580,0000.0%0.21%
+93.6%
MDVN  Medivation, Inc.$19,892,000
+31.1%
329,8760.0%0.21%
+30.6%
ACHN  Achillion Pharmaceuticals, Inc.$19,309,000
+1.0%
2,475,5150.0%0.20%0.0%
NVAX  Novavax, Inc.$17,297,000
+40.9%
2,379,2540.0%0.18%
+40.3%
PGNX SellProgenics Pharmaceuticals, Inc.$16,754,000
-11.7%
3,970,250
-8.7%
0.18%
-12.0%
XNCR  Xencor, Inc.$16,561,000
+41.5%
872,0720.0%0.17%
+41.5%
HALO SellHalozyme Therapeutics, Inc.$15,862,000
-13.3%
1,838,057
-4.8%
0.17%
-14.0%
ARRY  Array BioPharma Inc.$15,346,000
+20.7%
4,310,6660.0%0.16%
+20.1%
 Corsicanto Ltd. 3.5% 1/15/2032note 3.5% 1/15/2032$15,285,000
+26.3%
15,000,0000.0%0.16%
+25.0%
 Aegerion Pharmaceuticals, Inc. Notes 2.0% 8/15/2019note 2.0% 8/15/2019$14,840,000
+9.7%
26,517,0000.0%0.16%
+9.1%
DSCI  Derma Sciences, Inc.$14,784,000
+27.1%
3,752,3900.0%0.16%
+26.0%
INSM  Insmed Incorporated$14,790,000
-22.2%
1,500,0000.0%0.16%
-22.5%
GLPG SellGalapagos NVsponsored adr$14,416,000
+13.6%
259,894
-14.3%
0.15%
+12.7%
FOMX  Foamix Pharmaceuticals Ltd.$14,235,000
-2.6%
2,241,7020.0%0.15%
-3.2%
 BioMarin Pharmaceutical Inc. Notes 0.75% 10/15/2018note 0.75% 10/15/2018$13,573,000
-3.9%
12,228,0000.0%0.14%
-4.7%
BLUE Sellbluebird bio, Inc.$12,725,000
-15.2%
293,943
-16.7%
0.13%
-15.8%
MRTX SellMirati Therapeutics, Inc.$12,390,000
-82.3%
2,269,198
-30.6%
0.13%
-82.4%
TGTX  TG Therapeutics, Inc.$12,144,000
-28.9%
2,003,9910.0%0.13%
-29.4%
ALKS  Alkermes plc$10,816,000
+26.4%
250,2510.0%0.11%
+25.6%
IDRA BuyIdera Pharmaceuticals, Inc.$10,711,000
-22.6%
7,000,977
+0.2%
0.11%
-23.3%
ADHD  Alcobra Ltd.$10,490,000
+18.5%
2,336,3590.0%0.11%
+18.3%
ASND BuyAscendis Pharma A/Ssponsored adr$9,893,000
+5.5%
745,521
+47.5%
0.10%
+5.1%
MGNX  MacroGenics, Inc.$9,816,000
+44.0%
363,6760.0%0.10%
+43.1%
DERM BuyDermira, Inc.$9,548,000
+67.9%
326,428
+18.7%
0.10%
+66.7%
IMGN SellImmunoGen, Inc.$9,287,000
-75.5%
3,015,353
-32.3%
0.10%
-75.8%
MRUS NewMerus N.V.$8,972,0001,122,859
+100.0%
0.09%
LGND  Ligand Pharmaceuticals Incorporated$8,753,000
+11.4%
73,3860.0%0.09%
+10.8%
AGIO SellAgios Pharmaceuticals, Inc.$8,711,000
-30.3%
207,915
-32.5%
0.09%
-31.1%
ZGNX  Zogenix, Inc.$8,050,000
-12.9%
1,000,0000.0%0.08%
-13.4%
DMTX  Dimension Therapeutics, Inc.$7,511,000
-23.4%
1,251,8810.0%0.08%
-23.3%
AIMT BuyAimmune Therapeutics, Inc.$7,292,000
+115.1%
673,908
+169.6%
0.08%
+111.1%
VTAE  Vitae Pharmaceuticals, Inc.$6,880,000
+62.8%
637,5970.0%0.07%
+60.0%
SAGE  Sage Therapeutics, Inc.$6,751,000
-6.0%
224,0480.0%0.07%
-6.6%
AKTX BuyAkari Therapeutics plcsponsored adr$6,703,000
+20.9%
496,901
+25.5%
0.07%
+20.7%
PRQR SellProQR Therapeutics N.V.$5,973,000
-9.3%
1,234,095
-8.6%
0.06%
-8.7%
ALDR NewAlder BioPharmaceuticals, Inc.$5,427,000217,328
+100.0%
0.06%
RARE SellUltragenyx Pharmaceutical Inc.$5,424,000
-30.9%
110,894
-10.5%
0.06%
-31.3%
NTRA  Natera, Inc.$5,429,000
+26.7%
450,0000.0%0.06%
+26.7%
ARWR  Arrowhead Pharmaceuticals, Inc.$5,371,000
+10.4%
1,009,5090.0%0.06%
+9.8%
AERI  Aerie Pharmaceuticals, Inc.$5,269,000
+44.8%
299,3560.0%0.06%
+44.7%
CNCE SellConcert Pharmaceuticals, Inc.$5,279,000
-22.1%
470,058
-5.2%
0.06%
-22.5%
NERV NewMinerva Neurosciences, Inc.$5,191,000508,405
+100.0%
0.05%
 NeuroDerm Ltd.$4,956,000
+15.1%
305,0000.0%0.05%
+15.6%
MDGN BuyMedgenics, Inc.$4,887,000
+45.2%
880,539
+15.1%
0.05%
+45.7%
SYRS NewSyros Pharmaceuticals, Inc.$3,711,000204,465
+100.0%
0.04%
MCRB  Seres Therapeutics, Inc.$3,631,000
+9.4%
125,0000.0%0.04%
+8.6%
CPRX SellCatalyst Pharmaceuticals, Inc.$3,637,000
-43.5%
5,122,153
-6.8%
0.04%
-44.1%
ECYT SellEndocyte, Inc.$3,629,000
-31.0%
1,130,577
-33.3%
0.04%
-30.9%
LOXO  Loxo Oncology, Inc.$3,193,000
-15.2%
137,7350.0%0.03%
-17.5%
CRIS  Curis, Inc.$3,119,000
-3.1%
1,999,3030.0%0.03%
-2.9%
RXDX  Ignyta, Inc.$3,095,000
-19.9%
571,0000.0%0.03%
-22.0%
JUNO  Juno Therapeutics, Inc.$3,075,000
+0.9%
80,0000.0%0.03%0.0%
TRVN  Trevena, Inc.$2,835,000
-23.8%
450,0000.0%0.03%
-23.1%
GLYC NewGlycoMimetics, Inc.$2,772,000381,235
+100.0%
0.03%
NBRV  Nabriva Therapeutics AGsponsored adr$2,625,000
-16.3%
350,0000.0%0.03%
-15.2%
 Array BioPharma Inc. Notes 3.0% 6/1/2020note 3.0% 6/1/2020$2,544,000
+6.8%
3,000,0000.0%0.03%
+8.0%
OSIR  Osiris Therapeutics, Inc.$2,541,000
-10.8%
499,1930.0%0.03%
-10.0%
ADMS  Adamas Pharmaceuticals, Inc.$2,614,000
+4.7%
172,6300.0%0.03%
+3.8%
SNSS  Sunesis Pharmaceuticals, Inc.$2,437,000
+1.4%
4,450,0000.0%0.03%
+4.0%
SELB NewSelecta Biosciences, Inc.$2,504,000178,950
+100.0%
0.03%
EPZM  Epizyme, Inc.$2,381,000
-15.5%
232,4810.0%0.02%
-16.7%
PRTO  Proteon Therapeutics, Inc.$2,398,000
+3.8%
298,5910.0%0.02%
+4.2%
 Protalix BioTherapeutics, Inc. Notes 4.5% 9/15/18note 4.5% 9/15/2018$2,300,000
-1.5%
3,423,0000.0%0.02%
-4.0%
STML  Stemline Therapeutics, Inc.$2,258,000
+45.3%
333,4970.0%0.02%
+50.0%
NVIV  InVivo Therapeutics Holdings Corp.$2,312,000
-17.2%
400,0000.0%0.02%
-17.2%
AUPH  Aurinia Pharmaceuticals Inc.$2,120,000
+1.8%
711,4990.0%0.02%0.0%
AGLE NewAeglea BioTherapeutics, Inc.$1,965,000404,230
+100.0%
0.02%
 Trillium Therapeutics Inc.$1,902,000
-2.9%
211,7920.0%0.02%
-4.8%
MSTX SellMast Therapeutics, Inc.$1,818,000
+38.9%
3,868,026
-19.4%
0.02%
+35.7%
MDWD  MediWound Ltd.$1,783,000
-2.2%
226,0000.0%0.02%0.0%
OPHT  Ophthotech Corporation$1,819,000
+20.7%
35,6490.0%0.02%
+18.8%
QURE  uniQure N.V.$1,695,000
-38.0%
230,0000.0%0.02%
-37.9%
AMRN  Amarin Corporation plcsponsored adr new$1,732,000
+41.2%
801,8600.0%0.02%
+38.5%
ENTA  Enanta Pharmaceuticals, Inc.$1,662,000
-24.9%
75,3570.0%0.02%
-26.1%
CYTR  CytRx Corporation$1,472,000
-16.8%
659,9950.0%0.02%
-21.1%
KPTI  Karyopharm Therapeutics Inc.$1,456,000
-24.8%
216,9900.0%0.02%
-25.0%
ASMB  Assembly Biosciences, Inc.$1,388,000
+10.6%
250,0000.0%0.02%
+15.4%
CLLS  Cellectis S.A.sponsored ads$1,330,000
-3.3%
50,0000.0%0.01%
-6.7%
IONS  Ionis Pharmaceuticals, Inc.$1,331,000
-42.5%
57,1400.0%0.01%
-41.7%
GWPH  GW Pharmaceuticals plcads$1,374,000
+27.0%
15,0000.0%0.01%
+27.3%
IMDZ  Immune Design Corp.$1,215,000
-37.2%
148,9370.0%0.01%
-35.0%
DVAX  Dynavax Technologies Corporation$1,094,000
-24.2%
75,0000.0%0.01%
-26.7%
TENX  Tenax Therapeutics, Inc.$1,075,000
+24.9%
420,0000.0%0.01%
+22.2%
SCYX NewSCYNEXIS, Inc.$1,015,000467,600
+100.0%
0.01%
XLRN  Acceleron Pharma Inc.$977,000
+28.7%
28,7650.0%0.01%
+25.0%
AFMD  Affimed N.V.$992,000
-33.7%
400,0000.0%0.01%
-37.5%
PTN  Palatin Technologies, Inc.$905,000
-18.2%
2,050,0000.0%0.01%
-25.0%
ADAP  Adaptimmune Therapeutics plcsponsored adr$815,000
+0.2%
100,0000.0%0.01%0.0%
FPRX  Five Prime Therapeutics, Inc.$796,000
+1.8%
19,2470.0%0.01%0.0%
ALDX  Aldeyra Therapeutics, Inc.$808,000
+35.8%
142,0000.0%0.01%
+33.3%
ABUS  Arbutus Biopharma Corporation$628,000
-15.8%
180,5820.0%0.01%
-12.5%
ALNY  Alnylam Pharmaceuticals, Inc.$629,000
-11.7%
11,3400.0%0.01%
-12.5%
SNTA NewSynta Pharmaceuticals Corp.$526,0002,021,728
+100.0%
0.01%
RTTR  Ritter Pharmaceuticals, Inc.$612,000
+35.4%
400,0000.0%0.01%
+20.0%
WINT NewWindtree Therapeutics, Inc.$492,000254,973
+100.0%
0.01%
BDSI  BioDelivery Sciences International, Inc.$496,000
-26.8%
210,0210.0%0.01%
-28.6%
CMRX  Chimerix, Inc.$453,000
-23.1%
115,2160.0%0.01%
-16.7%
FMI  Foundation Medicine, Inc.$390,000
+2.6%
20,8920.0%0.00%0.0%
DNAI  ProNAi Therapeutics, Inc.$398,000
-70.5%
200,0000.0%0.00%
-71.4%
AKAOQ  Achaogen, Inc.$379,000
+37.3%
100,0000.0%0.00%
+33.3%
LJPC  La Jolla Pharmaceutical Company$220,000
-23.3%
13,7460.0%0.00%
-33.3%
CCXI  ChemoCentryx, Inc.$220,000
+80.3%
49,0640.0%0.00%
+100.0%
CYCCP  Cyclacel Pharmaceuticals, Inc.pfd conv ex 6%$83,000
+9.2%
13,2530.0%0.00%0.0%
BTXWS  BioTime, Inc.*w exp 10/1/201$9,000
-25.0%
20,0840.0%0.00%
ExitAptose Biosciences Inc.$0-33,397
-100.0%
-0.00%
DSCO ExitDiscovery Laboratories, Inc.$0-254,973
-100.0%
-0.00%
IRWD ExitIronwood Pharmaceuticals, Inc.$0-169,163
-100.0%
-0.02%
LBIO ExitLion Biotechnologies, Inc.$0-1,066,285
-100.0%
-0.06%
LIFE ExitaTyr Pharma, Inc.$0-2,137,606
-100.0%
-0.09%
GBT ExitGlobal Blood Therapeutics, Inc.$0-600,000
-100.0%
-0.10%
OMER ExitOmeros Corporation$0-749,250
-100.0%
-0.12%
ExitAnacor Pharmaceuticals Inc. 2.0% 15 OCT 2021note 2.0% 10/15/2021$0-42,000,000
-100.0%
-0.80%
ExitGilead Sciences, Inc. 1.625% 5/1/16note 1.625% 5/1/2016$0-20,944,000
-100.0%
-0.91%
ANAC ExitAnacor Pharmaceuticals, Inc.$0-5,122,375
-100.0%
-2.89%
Original filings

The following EDGAR filing(s) were analyzed to create this report:

  • View 13F-HR filed 2016-08-15
Signatures

The EDGAR filing(s) were signed by:

About Baker Brothers Advisors

Baker Brothers Advisors is a well-known investment management firm that specializes in the healthcare sector. The firm was founded in 2000 by brothers Julian and Felix Baker, who are both highly respected in the industry. Julian Baker is the CEO of the firm, while Felix Baker serves as a managing partner.

Baker Brothers Advisors has a reputation for investing in innovative healthcare companies that have the potential to make a significant impact on the industry. The firm has a long-term investment approach and is known for taking large positions in companies that it believes in. Some of the firm's most successful investments include companies such as Pharmacyclics, which was acquired by AbbVie for $21 billion, and Ariad Pharmaceuticals, which was acquired by Takeda for $5.2 billion.

The firm's investment strategy is led by its Chief Investment Officer, Dr. Robert Duggan, who has a background in both medicine and finance. Dr. Duggan is known for his ability to identify promising healthcare companies and for his willingness to take risks on early-stage companies.

Overall, Baker Brothers Advisors is a highly respected investment management firm that has a proven track record of success in the healthcare sector. While the firm's investment approach may not be suitable for all investors, those who are interested in the healthcare sector may want to consider Baker Brothers Advisors as a potential investment opportunity.

It's important to note that this information is for educational purposes only and has not been fact-checked. As with any investment, it's important to do your own research and consult with a financial advisor before making any investment decisions.

Top long-term holdings
NameQuarters ownedLatest quarter ownedMax weighting
Incyte Corporation42Q3 202337.6%
ACADIA Pharmaceuticals Inc.42Q3 202310.9%
Biomarin Pharmaceuticals Inc.42Q3 20235.9%
BioCryst Pharmaceuticals, Inc.42Q3 20231.7%
Cerus Corporation42Q3 20230.9%
Insmed Incorporated42Q3 20230.4%
Mirati Therapeutics, Inc.41Q3 20231.8%
Bluebird Bio Inc.41Q3 20230.3%
Heron Therapeutics, Inc.39Q3 20231.5%
ChemoCentryx, Inc.37Q3 20220.6%

View Baker Brothers Advisors's complete holdings history.

Latest significant ownerships (13-D/G)
Baker Brothers Advisors Q2 2016 significant holdings filed using form 13D/G when ownership exceeds 5% of a company's total stock issue.
FiledShares Percentage
Neoleukin Therapeutics, Inc.August 17, 20239,469,83820.0%
Mereo Biopharma Group plcAugust 10, 202314,604,3912.2%
Verastem, Inc.August 10, 2023? ?
TScan Therapeutics, Inc.June 02, 20232,793,9386.5%
ACADIA PHARMACEUTICALS INCMay 24, 202343,084,28026.5%
INCYTE CORPMarch 15, 202336,280,96716.3%
Seagen Inc.March 13, 202346,985,65625.1%
Talis Biomedical CorpMarch 10, 202337,569,14066.2%
Aeglea BioTherapeutics, Inc.February 14, 20236,384,0139.9%
Merus N.V.February 14, 2023? ?

View Baker Brothers Advisors's complete significant-ownership history.

Latest filings
TypeFiled
42024-04-23
SC 13D/A2024-04-23
42024-04-22
32024-04-18
SC 13D2024-04-18
32024-04-01
42024-04-01
42024-04-01
42024-04-01
SC 13D2024-04-01

View Baker Brothers Advisors's complete filings history.

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