Baker Brothers Advisors - Q1 2016 holdings

$9.48 Billion is the total value of Baker Brothers Advisors's 134 reported holdings in Q1 2016. The portfolio turnover from Q4 2015 to Q1 2016 was 11.3% .

 Value Shares↓ Weighting
INCY BuyIncyte Corporation$1,702,933,000
-19.4%
23,498,460
+20.7%
17.96%
+2.6%
SGEN BuySeattle Genetics, Inc.$1,517,126,000
-9.4%
43,235,267
+15.9%
16.00%
+15.4%
ALXN  Alexion Pharmaceuticals, Inc.$910,861,000
-27.0%
6,542,5990.0%9.61%
-7.1%
ABBV  AbbVie Inc.$821,016,000
-3.6%
14,373,5380.0%8.66%
+22.8%
ACAD BuyACADIA Pharmaceuticals Inc.$677,019,000
-7.3%
24,213,838
+18.2%
7.14%
+18.0%
 Incyte Corporation Notes 1.25% 11/15/2020 144Anote 1.25% 11/15/2020$432,150,000
-27.6%
274,500,0000.0%4.56%
-7.8%
 Incyte Corporation Notes 0.375% 11/15/2018 144Anote 0.375% 11/15/2018$397,943,000
-28.5%
259,000,0000.0%4.20%
-9.0%
BMRN BuyBioMarin Pharmaceutical Inc.$396,439,000
-8.0%
4,806,483
+16.8%
4.18%
+17.1%
GHDX BuyGenomic Health, Inc.$338,354,000
-29.6%
13,659,832
+0.0%
3.57%
-10.4%
ANAC BuyAnacor Pharmaceuticals, Inc.$273,791,000
-42.3%
5,122,375
+22.0%
2.89%
-26.5%
DBVT BuyDBV Technologies S.A.sponsored adr$179,336,000
-9.6%
5,509,560
+0.9%
1.89%
+15.1%
ACOR BuyAcorda Therapeutics, Inc.$96,836,000
-36.8%
3,661,082
+2.3%
1.02%
-19.5%
 BioMarin Pharmaceutical Inc. Notes 1.875% 4/23/2017note 1.875% 4/23/2017$89,825,000
-22.0%
22,379,0000.0%0.95%
-0.7%
 Clovis Oncology Inc. 2.5% 9/15/2021note 2.5% 9/15/2021$87,801,000
-20.9%
129,300,0000.0%0.93%
+0.8%
 Gilead Sciences, Inc. 1.625% 5/1/16note 1.625% 5/1/2016$85,863,000
-8.1%
20,944,0000.0%0.91%
+17.1%
CERS  Cerus Corporation$80,371,000
-6.2%
13,553,2750.0%0.85%
+19.4%
 Anacor Pharmaceuticals Inc. 2.0% 15 OCT 2021note 2.0% 10/15/2021$75,337,000
-50.5%
42,000,0000.0%0.80%
-37.0%
NewXenoport, Inc. Notes 2.5% 2/1/2022note 2.5% 2/1/2022$73,436,000100,000,000
+100.0%
0.77%
MRTX BuyMirati Therapeutics, Inc.$69,947,000
-25.1%
3,268,556
+10.6%
0.74%
-4.7%
BuyAcorda Therapeutics, Inc. Notes 1.75% 6/15/2021note 1.75% 6/15/2021$68,456,000
+15.4%
77,083,000
+49.4%
0.72%
+47.0%
AQXP BuyAquinox Pharmaceuticals, Inc.$68,377,000
-18.8%
7,752,487
+14.9%
0.72%
+3.3%
NVTA  Invitae Corporation$67,057,000
+24.6%
6,554,9670.0%0.71%
+58.5%
BGNE NewBeiGene, Ltd.sponsored adr$56,061,0001,912,680
+100.0%
0.59%
HRTX  Heron Therapeutics, Inc.$55,219,000
-28.9%
2,907,7840.0%0.58%
-9.5%
BLCM  Bellicum Pharmaceuticals, Inc.$45,494,000
-53.9%
4,865,6470.0%0.48%
-41.2%
BCRX BuyBioCryst Pharmaceuticals, Inc.$42,480,000
-71.0%
15,010,534
+5.6%
0.45%
-63.2%
IMGN  ImmunoGen, Inc.$37,935,000
-37.2%
4,452,4450.0%0.40%
-20.2%
ONCE  Spark Therapeutics, Inc.$37,253,000
-34.9%
1,262,3820.0%0.39%
-17.1%
NBIX BuyNeurocrine Biosciences, Inc.$35,414,000
-26.4%
895,422
+5.3%
0.37%
-6.5%
VSAR SellVersartis, Inc.$25,660,000
-36.1%
3,199,559
-1.3%
0.27%
-18.6%
SGMO  Sangamo BioSciences, Inc.$24,538,000
-33.7%
4,055,8760.0%0.26%
-15.6%
AAAP BuyAdvanced Accelerator Applications S.A.sponsored adr$21,538,000
+21.4%
615,033
+8.4%
0.23%
+54.4%
 Exelixis, Inc. Notes 4.25% 8/15/2019note 4.25% 8/15/2019$19,775,000
-15.0%
20,000,0000.0%0.21%
+8.3%
ACHN BuyAchillion Pharmaceuticals, Inc.$19,111,000
-11.4%
2,475,515
+23.8%
0.20%
+12.8%
INSM BuyInsmed Incorporated$19,005,000
+4.7%
1,500,000
+50.0%
0.20%
+33.3%
PGNX  Progenics Pharmaceuticals, Inc.$18,970,000
-28.9%
4,350,8080.0%0.20%
-9.5%
HALO  Halozyme Therapeutics, Inc.$18,287,000
-45.4%
1,931,0570.0%0.19%
-30.3%
TGTX  TG Therapeutics, Inc.$17,074,000
-28.6%
2,003,9910.0%0.18%
-9.1%
ITCI  Intra-Cellular Therapies, Inc.$16,935,000
-48.3%
609,1660.0%0.18%
-33.9%
XNPT  XenoPort, Inc.$15,675,000
-17.9%
3,475,6720.0%0.16%
+4.4%
MDVN SellMedivation, Inc.$15,168,000
-52.4%
329,876
-50.0%
0.16%
-39.4%
BLUE Buybluebird bio, Inc.$15,000,000
+65.5%
352,943
+150.1%
0.16%
+110.7%
FOMX BuyFoamix Pharmaceuticals Ltd.$14,616,000
-12.0%
2,241,702
+9.5%
0.15%
+11.6%
 BioMarin Pharmaceutical Inc. Notes 0.75% 10/15/2018note 0.75% 10/15/2018$14,125,000
-10.0%
12,228,0000.0%0.15%
+14.6%
IDRA BuyIdera Pharmaceuticals, Inc.$13,841,000
-35.9%
6,990,189
+0.1%
0.15%
-18.4%
 Aegerion Pharmaceuticals, Inc. Notes 2.0% 8/15/2019note 2.0% 8/15/2019$13,526,000
-22.9%
26,517,0000.0%0.14%
-1.4%
GLPG SellGalapagos NVsponsored adr$12,688,000
-45.4%
303,394
-17.8%
0.13%
-30.2%
ARRY  Array BioPharma Inc.$12,716,000
-30.1%
4,310,6660.0%0.13%
-11.3%
AGIO BuyAgios Pharmaceuticals, Inc.$12,501,000
+92.6%
307,915
+207.9%
0.13%
+144.4%
NVAX BuyNovavax, Inc.$12,277,000
-33.4%
2,379,254
+8.4%
0.13%
-15.7%
BuyCorsicanto Ltd. 3.5% 1/15/2032note 3.5% 1/15/2032$12,103,000
+170.2%
15,000,000
+200.0%
0.13%
+245.9%
XNCR  Xencor, Inc.$11,703,000
-8.2%
872,0720.0%0.12%
+16.0%
DSCI  Derma Sciences, Inc.$11,632,000
-32.2%
3,752,3900.0%0.12%
-13.4%
OMER BuyOmeros Corporation$11,493,000
+117.3%
749,250
+122.8%
0.12%
+175.0%
EXEL NewExelixis, Inc.$10,320,0002,580,000
+100.0%
0.11%
DMTX BuyDimension Therapeutics, Inc.$9,802,000
-29.6%
1,251,881
+1.4%
0.10%
-10.4%
GBT BuyGlobal Blood Therapeutics, Inc.$9,516,000
-26.4%
600,000
+50.0%
0.10%
-6.5%
ASND  Ascendis Pharma A/Ssponsored adr$9,377,000
+1.3%
505,5210.0%0.10%
+28.6%
ZGNX  Zogenix, Inc.$9,240,000
-37.3%
1,000,0000.0%0.10%
-20.5%
ADHD  Alcobra Ltd.$8,855,000
-39.6%
2,336,3590.0%0.09%
-23.8%
ALKS  Alkermes plc$8,556,000
-56.9%
250,2510.0%0.09%
-45.5%
LIFE SellaTyr Pharma, Inc.$8,422,000
-63.3%
2,137,606
-8.5%
0.09%
-53.2%
LGND  Ligand Pharmaceuticals Incorporated$7,859,000
-1.2%
73,3860.0%0.08%
+25.8%
RARE  Ultragenyx Pharmaceutical Inc.$7,844,000
-43.6%
123,8940.0%0.08%
-27.8%
SAGE BuySage Therapeutics, Inc.$7,183,000
+17.3%
224,048
+113.4%
0.08%
+49.0%
MGNX  MacroGenics, Inc.$6,819,000
-39.5%
363,6760.0%0.07%
-22.6%
CNCE  Concert Pharmaceuticals, Inc.$6,774,000
-28.0%
495,9080.0%0.07%
-9.0%
PRQR BuyProQR Therapeutics N.V.$6,587,000
-23.2%
1,349,719
+36.6%
0.07%
-2.8%
CPRX SellCatalyst Pharmaceuticals, Inc.$6,433,000
-68.3%
5,498,459
-33.6%
0.07%
-59.5%
DERM  Dermira, Inc.$5,687,000
-40.3%
275,0000.0%0.06%
-24.1%
AKTX  Akari Therapeutics plcsponsored adr$5,542,000
-3.4%
395,8820.0%0.06%
+20.8%
LBIO SellLion Biotechnologies, Inc.$5,417,000
-61.4%
1,066,285
-41.3%
0.06%
-50.9%
ECYT  Endocyte, Inc.$5,257,000
-22.7%
1,695,8650.0%0.06%
-1.8%
ARWR NewArrowhead Pharmaceuticals, Inc.$4,866,0001,009,509
+100.0%
0.05%
NTRA BuyNatera, Inc.$4,284,000
+58.7%
450,000
+80.0%
0.04%
+104.5%
VTAE BuyVitae Pharmaceuticals, Inc.$4,227,000
+24.5%
637,597
+239.9%
0.04%
+60.7%
 NeuroDerm Ltd.$4,307,000
-17.2%
305,0000.0%0.04%
+4.7%
RXDX  Ignyta, Inc.$3,866,000
-49.5%
571,0000.0%0.04%
-34.9%
LOXO  Loxo Oncology, Inc.$3,766,000
-3.9%
137,7350.0%0.04%
+25.0%
TRVN  Trevena, Inc.$3,722,000
-21.2%
450,0000.0%0.04%0.0%
AERI  Aerie Pharmaceuticals, Inc.$3,640,000
-50.1%
299,3560.0%0.04%
-36.7%
AIMT  Aimmune Therapeutics, Inc.$3,390,000
-26.5%
250,0000.0%0.04%
-5.3%
MDGN  Medgenics Inc.$3,366,000
-26.9%
765,0000.0%0.04%
-7.9%
MCRB  Seres Therapeutics, Inc.$3,320,000
-24.3%
125,0000.0%0.04%
-2.8%
CRIS  Curis, Inc.$3,219,000
-44.7%
1,999,3030.0%0.03%
-29.2%
NBRV  Nabriva Therapeutics AGsponsored adr$3,136,000
-6.9%
350,0000.0%0.03%
+17.9%
JUNO  Juno Therapeutics, Inc.$3,047,000
-13.4%
80,0000.0%0.03%
+10.3%
EPZM  Epizyme, Inc.$2,818,000
-24.3%
232,4810.0%0.03%
-3.2%
OSIR  Osiris Therapeutics, Inc.$2,850,000
-45.0%
499,1930.0%0.03%
-30.2%
NVIV NewInVivo Therapeutics Holdings Corp.$2,792,000400,000
+100.0%
0.03%
QURE BuyuniQure N.V.$2,732,000
+450.8%
230,000
+666.7%
0.03%
+625.0%
ADMS NewAdamas Pharmaceuticals, Inc.$2,496,000172,630
+100.0%
0.03%
 Protalix BioTherapeutics, Inc. Notes 4.5% 9/15/18note 4.5% 9/15/2018$2,334,000
-1.7%
3,423,0000.0%0.02%
+25.0%
 Array BioPharma Inc. Notes 3.0% 6/1/2020note 3.0% 6/1/2020$2,382,000
-15.4%
3,000,0000.0%0.02%
+8.7%
SNSS  Sunesis Pharmaceuticals, Inc.$2,403,000
-39.8%
4,450,0000.0%0.02%
-24.2%
PRTO  Proteon Therapeutics Inc.$2,311,000
-50.1%
298,5910.0%0.02%
-36.8%
IONS  Ionis Pharmaceuticals, Inc.$2,314,000
-34.6%
57,1400.0%0.02%
-17.2%
ENTA  Enanta Pharmaceuticals, Inc.$2,213,000
-11.1%
75,3570.0%0.02%
+9.5%
AUPH  Aurinia Pharmaceuticals Inc.$2,082,000
+16.4%
711,4990.0%0.02%
+46.7%
 Trillium Therapeutics Inc.$1,959,000
-26.7%
211,7920.0%0.02%
-4.5%
IRWD  Ironwood Pharmaceuticals, Inc.$1,851,000
-5.6%
169,1630.0%0.02%
+25.0%
IMDZ  Immune Design Corp.$1,936,000
-35.3%
148,9370.0%0.02%
-20.0%
KPTI  Karyopharm Therapeutics Inc.$1,936,000
-32.7%
216,9900.0%0.02%
-16.7%
CYTR  CytRx Corporation$1,769,000
+1.1%
659,9950.0%0.02%
+35.7%
MDWD BuyMediWound Ltd.$1,824,000
-5.1%
226,000
+0.4%
0.02%
+18.8%
AFMD  Affimed N.V.$1,496,000
-47.5%
400,0000.0%0.02%
-33.3%
OPHT  Ophthotech Corporation$1,507,000
-46.2%
35,6490.0%0.02%
-30.4%
STML  Stemline Therapeutics, Inc.$1,554,000
-26.1%
333,4970.0%0.02%
-5.9%
DVAX  Dynavax Technologies Corporation$1,443,000
-20.4%
75,0000.0%0.02%0.0%
CLLS  Cellectis S.A.sponsored ads$1,375,000
-11.4%
50,0000.0%0.02%
+15.4%
MSTX  Mast Therapeutics, Inc.$1,309,000
-35.1%
4,797,4420.0%0.01%
-17.6%
DNAI  ProNai Therapeutics, Inc.$1,348,000
-55.2%
200,0000.0%0.01%
-44.0%
ASMB  Assembly Biosciences, Inc.$1,255,000
-33.2%
250,0000.0%0.01%
-18.8%
AMRN SellAmarin Corporation plcsponsored adr new$1,227,000
-70.6%
801,860
-63.6%
0.01%
-62.9%
PTN  Palatin Technologies, Inc.$1,107,000
-18.7%
2,050,0000.0%0.01%
+9.1%
GWPH NewGW Pharmaceuticals plcads$1,082,00015,000
+100.0%
0.01%
TENX  Tenax Therapeutics, Inc.$861,000
-37.5%
420,0000.0%0.01%
-18.2%
ADAP  Adaptimmune Therapeutics plcsponsored adr$813,000
-32.6%
100,0000.0%0.01%
-10.0%
ALNY  Alnylam Pharmaceuticals, Inc.$712,000
-33.3%
11,3400.0%0.01%
-11.1%
ABUS  Arbutus Biopharma Corporation$746,000
-7.2%
180,5820.0%0.01%
+14.3%
FPRX  Five Prime Therapeutics, Inc.$782,000
-2.1%
19,2470.0%0.01%
+14.3%
XLRN  Acceleron Pharma, Inc.$759,000
-45.9%
28,7650.0%0.01%
-33.3%
BDSI  BioDelivery Sciences International, Inc.$678,000
-32.6%
210,0210.0%0.01%
-12.5%
CMRX  Chimerix, Inc.$589,000
-42.9%
115,2160.0%0.01%
-33.3%
ALDX  Aldeyra Therapeutics, Inc.$595,000
-38.2%
142,0000.0%0.01%
-25.0%
RTTR  Ritter Pharmaceuticals, Inc.$452,000
-33.5%
400,0000.0%0.01%
-16.7%
DSCO NewDiscovery Laboratories, Inc.$426,000254,973
+100.0%
0.00%
FMI  Foundation Medicine, Inc.$380,000
-13.6%
20,8920.0%0.00%0.0%
LJPC  La Jolla Pharmaceutical Company$287,000
-22.6%
13,7460.0%0.00%0.0%
AKAOQ  Achaogen, Inc.$276,000
-51.9%
100,0000.0%0.00%
-40.0%
 Aptose Biosciences Inc.$100,000
+19.0%
33,3970.0%0.00%0.0%
CYCCP  Cyclacel Pharmaceuticals, Inc.pfd conv ex 6%$76,000
+46.2%
13,2530.0%0.00%
CCXI  ChemoCentryx, Inc.$122,000
-69.3%
49,0640.0%0.00%
-66.7%
BTXWS  BioTime, Inc.*w exp 10/1/201$12,000
-50.0%
20,0840.0%0.00%
DSCO ExitDiscovery Laboratories, Inc.$0-3,569,643
-100.0%
-0.01%
MRNS ExitMarinus Pharmaceuticals, Inc.$0-200,000
-100.0%
-0.01%
OHRP ExitOhr Pharmaceuticals, Inc.$0-370,370
-100.0%
-0.02%
FLXN ExitFlexion Therapeutics, Inc.$0-146,642
-100.0%
-0.02%
ARWR ExitArrowhead Research Corp.$0-1,009,509
-100.0%
-0.05%
GILD ExitGilead Sciences, Inc.$0-249,995
-100.0%
-0.21%
DYAX ExitDyax Corp.$0-8,310,017
-100.0%
-2.59%
Original filings

The following EDGAR filing(s) were analyzed to create this report:

  • View 13F-HR filed 2016-05-16
Signatures

The EDGAR filing(s) were signed by:

About Baker Brothers Advisors

Baker Brothers Advisors is a well-known investment management firm that specializes in the healthcare sector. The firm was founded in 2000 by brothers Julian and Felix Baker, who are both highly respected in the industry. Julian Baker is the CEO of the firm, while Felix Baker serves as a managing partner.

Baker Brothers Advisors has a reputation for investing in innovative healthcare companies that have the potential to make a significant impact on the industry. The firm has a long-term investment approach and is known for taking large positions in companies that it believes in. Some of the firm's most successful investments include companies such as Pharmacyclics, which was acquired by AbbVie for $21 billion, and Ariad Pharmaceuticals, which was acquired by Takeda for $5.2 billion.

The firm's investment strategy is led by its Chief Investment Officer, Dr. Robert Duggan, who has a background in both medicine and finance. Dr. Duggan is known for his ability to identify promising healthcare companies and for his willingness to take risks on early-stage companies.

Overall, Baker Brothers Advisors is a highly respected investment management firm that has a proven track record of success in the healthcare sector. While the firm's investment approach may not be suitable for all investors, those who are interested in the healthcare sector may want to consider Baker Brothers Advisors as a potential investment opportunity.

It's important to note that this information is for educational purposes only and has not been fact-checked. As with any investment, it's important to do your own research and consult with a financial advisor before making any investment decisions.

Top long-term holdings
NameQuarters ownedLatest quarter ownedMax weighting
Incyte Corporation42Q3 202337.6%
ACADIA Pharmaceuticals Inc.42Q3 202310.9%
Biomarin Pharmaceuticals Inc.42Q3 20235.9%
BioCryst Pharmaceuticals, Inc.42Q3 20231.7%
Cerus Corporation42Q3 20230.9%
Insmed Incorporated42Q3 20230.4%
Mirati Therapeutics, Inc.41Q3 20231.8%
Bluebird Bio Inc.41Q3 20230.3%
Heron Therapeutics, Inc.39Q3 20231.5%
ChemoCentryx, Inc.37Q3 20220.6%

View Baker Brothers Advisors's complete holdings history.

Latest significant ownerships (13-D/G)
Baker Brothers Advisors Q1 2016 significant holdings filed using form 13D/G when ownership exceeds 5% of a company's total stock issue.
FiledShares Percentage
Neoleukin Therapeutics, Inc.August 17, 20239,469,83820.0%
Mereo Biopharma Group plcAugust 10, 202314,604,3912.2%
Verastem, Inc.August 10, 2023? ?
TScan Therapeutics, Inc.June 02, 20232,793,9386.5%
ACADIA PHARMACEUTICALS INCMay 24, 202343,084,28026.5%
INCYTE CORPMarch 15, 202336,280,96716.3%
Seagen Inc.March 13, 202346,985,65625.1%
Talis Biomedical CorpMarch 10, 202337,569,14066.2%
Aeglea BioTherapeutics, Inc.February 14, 20236,384,0139.9%
Merus N.V.February 14, 2023? ?

View Baker Brothers Advisors's complete significant-ownership history.

Latest filings
TypeFiled
42024-04-23
SC 13D/A2024-04-23
42024-04-22
32024-04-18
SC 13D2024-04-18
32024-04-01
42024-04-01
42024-04-01
42024-04-01
SC 13D2024-04-01

View Baker Brothers Advisors's complete filings history.

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