Baker Brothers Advisors - Q2 2015 holdings

$11.4 Billion is the total value of Baker Brothers Advisors's 126 reported holdings in Q2 2015. The portfolio turnover from Q1 2015 to Q2 2015 was 18.5% .

 Value Shares↓ Weighting
INCY BuyIncyte Corporation$1,549,140,000
+13.8%
14,865,559
+0.1%
13.59%
+20.1%
SGEN BuySeattle Genetics, Inc.$1,494,121,000
+46.4%
30,870,262
+6.9%
13.11%
+54.4%
ALXN NewAlexion Pharmaceuticals, Inc.$1,182,706,0006,542,599
+100.0%
10.37%
ABBV NewAbbVie Inc.$965,758,00014,373,538
+100.0%
8.47%
ACAD  ACADIA Pharmaceuticals Inc.$857,763,000
+28.5%
20,481,4420.0%7.52%
+35.5%
 Incyte Corporation Notes 1.25% 11/15/2020 144Aconv bonds$567,758,000
+11.7%
274,500,0000.0%4.98%
+17.8%
BMRN SellBioMarin Pharmaceutical Inc.$560,148,000
+7.0%
4,095,247
-2.5%
4.91%
+12.8%
 Incyte Corporation Notes 0.375% 11/15/2018 144Aconv bonds$529,519,000
+12.2%
259,000,0000.0%4.64%
+18.3%
 Incyte Corporation Notes 4.75% 10/1/2015 144Aconv bonds$478,833,000
+13.6%
40,446,0000.0%4.20%
+19.8%
GHDX BuyGenomic Health Inc.$379,545,000
-9.0%
13,657,598
+0.0%
3.33%
-4.1%
ANAC SellAnacor Pharmaceuticals, Inc.$280,722,000
+15.4%
3,625,498
-13.8%
2.46%
+21.7%
DYAX BuyDyax Corp.$210,056,000
+108.2%
7,926,630
+31.6%
1.84%
+119.7%
BCRX BuyBioCryst Pharmaceuticals, Inc.$172,849,000
+82.7%
11,577,299
+10.5%
1.52%
+92.6%
 BioMarin Pharmaceutical Inc. Notes 1.875% 4/23/2017conv bonds$149,970,000
+9.5%
22,379,0000.0%1.32%
+15.5%
 Gilead, Inc. 1.625% 5/1/16conv bonds$107,926,000
+19.7%
20,944,0000.0%0.95%
+26.3%
NVTA  Invitae Corporation$97,538,000
-11.2%
6,554,9670.0%0.86%
-6.3%
BLCM  Bellicum Pharmaceuticals, Inc.$89,134,000
-8.2%
4,190,5940.0%0.78%
-3.2%
MRTX  Mirati Therapeutics, Inc.$88,276,000
+7.3%
2,805,0740.0%0.77%
+13.2%
HRTX BuyHeron Therapeutics, Inc.$87,491,000
+130.6%
2,807,784
+7.7%
0.77%
+142.7%
ONCE SellSpark Therapeutics, Inc.$76,084,000
-26.0%
1,262,382
-4.9%
0.67%
-22.1%
 Medivation, Inc. 2.625% 4/1/17conv bonds$75,011,000
-11.7%
33,889,0000.0%0.66%
-6.8%
CERS  Cerus Corporation$70,341,000
+24.5%
13,553,2750.0%0.62%
+31.3%
 Acorda Therapeutics, Inc. Notes 1.75% 6/15/2021conv bonds$60,049,000
-1.2%
59,583,0000.0%0.53%
+4.4%
XOMA SellXOMA Corporation$56,972,000
+6.4%
14,683,513
-0.2%
0.50%
+12.4%
DBVT BuyDBV Technologies S.A.sponsored adr$55,451,000
+56.2%
1,862,019
+22.6%
0.49%
+64.7%
VSAR BuyVersartis, Inc.$52,305,000
-4.4%
3,436,585
+15.4%
0.46%
+0.9%
ALDR BuyAlder Biopharmaceuticals Inc.$47,233,000
+86.1%
891,688
+1.4%
0.41%
+96.2%
HALO SellHalozyme Therapeutics, Inc.$43,603,000
+35.8%
1,931,057
-14.1%
0.38%
+43.1%
LIFE NewaTyr Pharma Inc.$43,247,0002,335,125
+100.0%
0.38%
XNPT  XenoPort, Inc.$39,898,000
-13.9%
6,508,6220.0%0.35%
-9.1%
ARRY SellArray BioPharma Inc.$39,529,000
-5.2%
5,482,505
-3.1%
0.35%0.0%
INSM  Insmed, Inc.$38,669,000
+17.4%
1,583,4900.0%0.34%
+23.7%
SGMO BuySangamo BioSciences, Inc.$35,831,000
+62.7%
3,230,932
+130.0%
0.31%
+71.6%
IMGN BuyImmunoGen, Inc.$33,368,000
+273.0%
2,320,424
+132.2%
0.29%
+295.9%
TGTX SellTG Therapeutics, Inc.$33,246,000
+4.7%
2,003,991
-2.3%
0.29%
+10.6%
PGNX  Progenics Pharmaceuticals, Inc.$32,457,000
+24.7%
4,350,8080.0%0.28%
+31.9%
CPRX SellCatalyst Pharmaceuticals, Inc.$30,296,000
-7.5%
7,335,692
-3.0%
0.27%
-2.2%
GILD  Gilead Sciences, Inc.$29,269,000
+19.3%
249,9950.0%0.26%
+26.0%
KYTH BuyKythera Biopharmaceuticals, Inc.$29,201,000
+64.4%
387,741
+9.4%
0.26%
+73.0%
IDRA BuyIdera Pharmaceuticals, Inc.$25,862,000
+0.1%
6,970,902
+0.1%
0.23%
+5.6%
NBIX  Neurocrine Biosciences, Inc.$25,897,000
+20.3%
542,2360.0%0.23%
+26.8%
BLUE Buybluebird bio, Inc.$25,442,000
+43.7%
151,105
+3.1%
0.22%
+51.7%
DSCI  Derma Sciences, Inc.$24,758,000
-15.5%
3,457,8410.0%0.22%
-11.1%
ACOR  Acorda Therapeutics, Inc.$24,628,000
+0.2%
738,9160.0%0.22%
+5.4%
NVAX  Novavax, Inc.$21,675,000
+34.7%
1,945,6870.0%0.19%
+41.8%
FOMX BuyFoamix Pharmaceuticals Ltd.$20,981,000
+24.5%
2,046,967
+12.3%
0.18%
+31.4%
XNCR  Xencor, Inc.$19,159,000
+43.4%
872,0720.0%0.17%
+51.4%
GLPG NewGalapagos NVsponsored adr$19,018,000369,276
+100.0%
0.17%
 BioMarin Pharmaceutical Inc. Notes 0.75% 10/15/2018conv bonds$18,940,000
+5.4%
12,228,0000.0%0.17%
+11.4%
CLVS  Clovis Oncology, Inc.$17,807,000
+18.4%
202,6300.0%0.16%
+24.8%
OMER BuyOmeros Corporation$17,354,000
+23.6%
964,621
+51.3%
0.15%
+29.9%
ZGNX BuyZogenix, Inc.$16,848,000
+435.0%
10,028,564
+336.3%
0.15%
+469.2%
LBIO BuyLion Biotechnologies, Inc.$16,666,000
+3.9%
1,817,429
+37.2%
0.15%
+9.8%
PRQR BuyProQR Therapeutics N.V.$16,475,000
+88.2%
988,299
+147.1%
0.14%
+98.6%
RPRX SellRepros Therapeutics Inc.$13,985,000
-18.6%
1,955,944
-2.2%
0.12%
-14.0%
ACHN BuyAchillion Pharmaceuticals, Inc.$13,500,000
+539.2%
1,523,739
+611.2%
0.12%
+555.6%
RARE SellUltragenyx Pharmaceuticals$12,686,000
+37.2%
123,894
-16.8%
0.11%
+44.2%
THLD  Threshold Pharmaceuticals, Inc.$11,819,000
-0.5%
2,925,5190.0%0.10%
+5.1%
ADHD  Alcobra Ltd.$11,706,000
+16.2%
1,789,8710.0%0.10%
+22.6%
MGNX  MacroGenics, Inc.$11,582,000
+21.0%
305,0430.0%0.10%
+27.5%
AGIO SellAgios Pharmaceuticals, Inc.$11,114,000
-21.4%
100,000
-33.3%
0.10%
-17.8%
LJPC  La Jolla Pharmaceutical Company$10,098,000
+33.9%
412,0080.0%0.09%
+41.3%
ZFGN BuyZafgen, Inc.$9,962,000
+165.4%
287,677
+203.6%
0.09%
+180.6%
OSIR  Osiris Therapeutics, Inc.$9,714,000
+10.7%
499,1930.0%0.08%
+16.4%
SNSS  Sunesis Pharmaceuticals, Inc.$9,632,000
+22.9%
3,200,0000.0%0.08%
+29.2%
RXDX  Ignyta, Inc.$8,616,000
+51.7%
571,0000.0%0.08%
+61.7%
AQXP BuyAquinox Pharmaceuticals, Inc.$8,310,000
-14.9%
1,197,366
+0.8%
0.07%
-9.9%
SAGE BuySage Therapeutics, Inc.$7,665,000
+103.5%
105,000
+40.0%
0.07%
+116.1%
LGND  Ligand Pharmaceuticals Incorporated$7,405,000
+30.9%
73,3860.0%0.06%
+38.3%
CNCE  Concert Pharmaceuticals, Inc.$7,384,000
-1.7%
495,9080.0%0.06%
+4.8%
ARWR SellArrowhead Research Corp.$7,218,000
-17.3%
1,009,509
-21.8%
0.06%
-13.7%
KPTI  Karyopharm Therapeutics Inc.$5,904,000
-11.1%
216,9900.0%0.05%
-5.5%
EPZM  Epizyme, Inc.$5,580,000
+27.8%
232,4810.0%0.05%
+36.1%
AMRN  Amarin Corporation plcsponsored adr$5,426,000
+5.1%
2,205,7100.0%0.05%
+11.6%
CMRX  Chimerix, Inc.$5,323,000
+22.6%
115,2160.0%0.05%
+30.6%
AFMD  Affimed N.V.$5,388,000
+113.8%
400,0000.0%0.05%
+123.8%
VNDA SellVanda Pharmaceuticals Inc.$5,201,000
-68.0%
409,881
-76.6%
0.05%
-65.9%
AERI  Aerie Pharmaceuticals, Inc.$5,284,000
-43.7%
299,3560.0%0.05%
-41.0%
MCRB NewSeres Therapeutics, Inc.$5,188,000125,000
+100.0%
0.05%
CYTR  CytRx Corporation$4,910,000
+10.4%
1,319,9890.0%0.04%
+16.2%
ASMB  Assembly Biosciences, Inc.$4,815,000
+45.5%
250,0000.0%0.04%
+50.0%
RCPT  Receptos, Inc.$4,542,000
+15.2%
23,9000.0%0.04%
+21.2%
JUNO SellJuno Therapeutics, Inc.$4,266,000
-29.7%
80,000
-20.0%
0.04%
-26.0%
STML  Stemline Therapeutics, Inc.$3,925,000
-18.7%
333,4970.0%0.03%
-15.0%
 NeuroDerm Ltd.$3,838,000
+14.4%
250,0000.0%0.03%
+21.4%
 Array BioPharma Inc. Notes 3.0% 6/1/2020conv bonds$3,780,000
+0.6%
3,000,0000.0%0.03%
+6.5%
CRIS NewCuris, Inc.$3,567,0001,077,663
+100.0%
0.03%
ENTA  Enanta Pharmaceuticals, Inc.$3,390,000
+46.9%
75,3570.0%0.03%
+57.9%
ISIS  Isis Pharmaceuticals, Inc.$3,288,000
-9.6%
57,1400.0%0.03%
-3.3%
ITCI  Intra-Cellular Therapies, Inc.$3,328,000
+33.8%
104,1660.0%0.03%
+38.1%
PRTO BuyProteon Therapeutics, Inc.$3,157,000
+57.0%
176,762
+2.2%
0.03%
+64.7%
IMDZ NewImmune Design Corp.$3,076,000148,937
+100.0%
0.03%
VTAE  Vitae Pharmaceuticals, Inc.$2,701,000
+22.9%
187,5970.0%0.02%
+33.3%
BLPH  Bellerophon Therapeutics, Inc.$2,776,000
-13.6%
350,0000.0%0.02%
-11.1%
SellProtalix BioTherapeutics, Inc. Notes 4.5% 9/15/18conv bonds$2,606,000
-0.2%
3,423,000
-2.2%
0.02%
+4.5%
DSCO  Discovery Laboratories, Inc.$2,427,000
-42.9%
3,569,6430.0%0.02%
-40.0%
ZIOP  ZIOPHARM Oncology, Inc.$2,271,000
+11.4%
189,2590.0%0.02%
+17.6%
MSTX  Mast Therapeutics, Inc.$2,307,000
+1.1%
4,707,4640.0%0.02%
+5.3%
MRNS  Marinus Pharmaceuticals, Inc.$2,320,000
+29.0%
200,0000.0%0.02%
+33.3%
TKMR  Tekmira Pharmaceuticals Corp.$2,142,000
-32.1%
180,5820.0%0.02%
-26.9%
AUPH  Aurinia Pharmaceuticals Inc.$2,130,000
-31.7%
711,4990.0%0.02%
-26.9%
IRWD  Ironwood Pharmaceuticals, Inc.$2,040,000
-24.6%
169,1630.0%0.02%
-21.7%
PTN  Palatin Technologies, Inc.$1,825,000
-12.7%
2,050,0000.0%0.02%
-5.9%
OPHT  Ophthotech Corporation$1,856,000
+11.9%
35,6490.0%0.02%
+14.3%
ADAP NewAdaptimmune Therapeutics plcsponsored adr$1,833,000100,000
+100.0%
0.02%
LOXO  Loxo Oncology, Inc.$1,803,000
+44.8%
100,0000.0%0.02%
+60.0%
CLLS  Cellectis S.A.sponsored adr$1,804,000
+4.3%
50,0000.0%0.02%
+14.3%
RTTR NewRitter Pharmaceuticals, Inc.$1,780,000400,000
+100.0%
0.02%
ASND  Ascendis Pharma A/Ssponsored adr$1,768,000
+1.9%
100,0000.0%0.02%
+14.3%
BDSI SellBioDelivery Sciences International, Inc.$1,672,000
-37.8%
210,021
-17.9%
0.02%
-31.8%
DERM  Dermira, Inc.$1,755,000
+14.3%
100,0000.0%0.02%
+15.4%
BOTA SellBiota Pharmaceuticals, Inc.$1,719,000
-13.4%
830,440
-3.8%
0.02%
-11.8%
MDWD  MediWound Ltd.$1,591,000
-2.3%
225,0000.0%0.01%0.0%
ALNY  Alnylam Pharmaceuticals, Inc.$1,359,000
+14.8%
11,3400.0%0.01%
+20.0%
TENX NewTenax Therapeutics Inc.$1,311,000355,348
+100.0%
0.01%
ALDX  Aldeyra Therapeutics, Inc.$1,102,000
-23.8%
142,0000.0%0.01%
-16.7%
OHRP  Ohr Pharmaceuticals, Inc.$930,000
-1.2%
370,3700.0%0.01%0.0%
XLRN  Acceleron Pharma, Inc.$910,000
-16.9%
28,7650.0%0.01%
-11.1%
QURE  UniQure B.V.$810,000
+11.0%
30,0000.0%0.01%
+16.7%
FMI SellFoundation Medicine, Inc.$707,000
-88.2%
20,892
-83.2%
0.01%
-88.0%
AKAOQ  Achaogen, Inc.$603,000
-38.2%
100,0000.0%0.01%
-37.5%
FPRX  Five Prime Therapeutics, Inc.$478,000
+8.6%
19,2470.0%0.00%0.0%
CCXI  ChemoCentryx, Inc.$404,000
+9.2%
49,0640.0%0.00%
+33.3%
CYCCP  Cyclacel Pharmaceuticals, Inc. Pfd. Conv. Ex 6%pfd conv ex 6%$85,000
-1.2%
13,2530.0%0.00%0.0%
 Aptose Biosciences, Inc.$170,000
-6.1%
33,3970.0%0.00%
-50.0%
BTXWS  BioTime, Inc. Rightswarrants$23,000
-42.5%
20,0840.0%0.00%
BIOD ExitBiodel Inc.$0-30,179
-100.0%
0.00%
AEGR ExitAegerion Pharmaceuticals, Inc.$0-14,300
-100.0%
-0.00%
SNTA ExitSynta Pharmaceuticals Corp.$0-489,053
-100.0%
-0.01%
RIGL ExitRigel Pharmaceuticals Inc.$0-357,187
-100.0%
-0.01%
OSUR ExitOrasure Technologies Inc.$0-229,397
-100.0%
-0.01%
ASPX ExitAuspex Pharmaceuticals, Inc.$0-25,000
-100.0%
-0.02%
LPCN ExitLipocine Inc.$0-489,175
-100.0%
-0.03%
INFI ExitInfinity Pharmaceuticals Inc.$0-305,037
-100.0%
-0.04%
TTHI ExitTransition Therapeutics, Inc.$0-769,230
-100.0%
-0.04%
CLDN ExitCelladon Corp$0-366,806
-100.0%
-0.06%
ExitSalix Pharmaceuticals Inc. 1.5% 3/15/19conv bonds$0-14,668,000
-100.0%
-0.32%
ExitSalix Pharmaceuticals Inc. 2.75% 5/15/15conv bonds$0-216,077,000
-100.0%
-6.66%
GEVA ExitSynageva Biopharma Corp.$0-11,660,432
-100.0%
-9.46%
PCYC ExitPharmacyclics Inc.$0-9,039,652
-100.0%
-19.24%
Original filings

The following EDGAR filing(s) were analyzed to create this report:

  • View 13F-HR filed 2015-08-14
Signatures

The EDGAR filing(s) were signed by:

About Baker Brothers Advisors

Baker Brothers Advisors is a well-known investment management firm that specializes in the healthcare sector. The firm was founded in 2000 by brothers Julian and Felix Baker, who are both highly respected in the industry. Julian Baker is the CEO of the firm, while Felix Baker serves as a managing partner.

Baker Brothers Advisors has a reputation for investing in innovative healthcare companies that have the potential to make a significant impact on the industry. The firm has a long-term investment approach and is known for taking large positions in companies that it believes in. Some of the firm's most successful investments include companies such as Pharmacyclics, which was acquired by AbbVie for $21 billion, and Ariad Pharmaceuticals, which was acquired by Takeda for $5.2 billion.

The firm's investment strategy is led by its Chief Investment Officer, Dr. Robert Duggan, who has a background in both medicine and finance. Dr. Duggan is known for his ability to identify promising healthcare companies and for his willingness to take risks on early-stage companies.

Overall, Baker Brothers Advisors is a highly respected investment management firm that has a proven track record of success in the healthcare sector. While the firm's investment approach may not be suitable for all investors, those who are interested in the healthcare sector may want to consider Baker Brothers Advisors as a potential investment opportunity.

It's important to note that this information is for educational purposes only and has not been fact-checked. As with any investment, it's important to do your own research and consult with a financial advisor before making any investment decisions.

Top long-term holdings
NameQuarters ownedLatest quarter ownedMax weighting
Incyte Corporation42Q3 202337.6%
ACADIA Pharmaceuticals Inc.42Q3 202310.9%
Biomarin Pharmaceuticals Inc.42Q3 20235.9%
BioCryst Pharmaceuticals, Inc.42Q3 20231.7%
Cerus Corporation42Q3 20230.9%
Insmed Incorporated42Q3 20230.4%
Mirati Therapeutics, Inc.41Q3 20231.8%
Bluebird Bio Inc.41Q3 20230.3%
Heron Therapeutics, Inc.39Q3 20231.5%
ChemoCentryx, Inc.37Q3 20220.6%

View Baker Brothers Advisors's complete holdings history.

Latest significant ownerships (13-D/G)
Baker Brothers Advisors Q2 2015 significant holdings filed using form 13D/G when ownership exceeds 5% of a company's total stock issue.
FiledShares Percentage
Neoleukin Therapeutics, Inc.August 17, 20239,469,83820.0%
Mereo Biopharma Group plcAugust 10, 202314,604,3912.2%
Verastem, Inc.August 10, 2023? ?
TScan Therapeutics, Inc.June 02, 20232,793,9386.5%
ACADIA PHARMACEUTICALS INCMay 24, 202343,084,28026.5%
INCYTE CORPMarch 15, 202336,280,96716.3%
Seagen Inc.March 13, 202346,985,65625.1%
Talis Biomedical CorpMarch 10, 202337,569,14066.2%
Aeglea BioTherapeutics, Inc.February 14, 20236,384,0139.9%
Merus N.V.February 14, 2023? ?

View Baker Brothers Advisors's complete significant-ownership history.

Latest filings
TypeFiled
42024-04-23
SC 13D/A2024-04-23
42024-04-22
32024-04-18
SC 13D2024-04-18
32024-04-01
42024-04-01
42024-04-01
42024-04-01
SC 13D2024-04-01

View Baker Brothers Advisors's complete filings history.

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