Baker Brothers Advisors - Q1 2015 holdings

$12 Billion is the total value of Baker Brothers Advisors's 130 reported holdings in Q1 2015. The portfolio turnover from Q4 2014 to Q1 2015 was 24.0% .

 Value Shares↓ Weighting
PCYC SellPharmacyclics Inc.$2,313,699,000
+107.3%
9,039,652
-1.0%
19.24%
+68.9%
INCY  Incyte Corp.$1,360,744,000
+25.4%
14,845,5590.0%11.32%
+2.2%
GEVA BuySynageva Biopharma Corp.$1,137,242,000
+15.0%
11,660,432
+9.4%
9.46%
-6.3%
SGEN BuySeattle Genetics, Inc.$1,020,792,000
+14.0%
28,876,712
+3.6%
8.49%
-7.1%
SellSalix Pharmaceuticals Inc. 2.75% 5/15/15conv bonds$801,152,000
+47.6%
216,077,000
-1.5%
6.66%
+20.3%
ACAD  Acadia Pharmaceuticals Inc.$667,490,000
+2.6%
20,481,4420.0%5.55%
-16.3%
BMRN BuyBiomarin Pharmaceuticals Inc.$523,461,000
+55.9%
4,200,456
+13.1%
4.35%
+27.0%
 Incyte Corp. Notes 1.25% 11/15/2020 144Aconv bonds$508,427,000
+20.6%
274,500,0000.0%4.23%
-1.7%
 Incyte Corp. Notes 0.375% 11/15/2018 144Aconv bonds$471,944,000
+21.6%
259,000,0000.0%3.92%
-0.9%
 Incyte Corp. Notes 4.75% 10/1/2015 144Aconv bonds$421,673,000
+25.4%
40,446,0000.0%3.51%
+2.2%
GHDX BuyGenomic Health Inc.$417,220,000
-4.4%
13,656,942
+0.0%
3.47%
-22.1%
ANAC  Anacor Pharmaceuticals Inc.$243,242,000
+79.4%
4,204,7020.0%2.02%
+46.2%
SellBiomarin Pharmaceuticals Inc. Notes 1.875% 4/23/2017conv bonds$136,987,000
+34.2%
22,379,000
-2.3%
1.14%
+9.3%
NVTA NewInvitae Corp.$109,861,0006,554,967
+100.0%
0.91%
ONCE NewSpark Therapeutics, Inc.$102,878,0001,327,451
+100.0%
0.86%
DYAX SellDyax Corp.$100,890,000
+16.5%
6,021,485
-2.2%
0.84%
-5.1%
BLCM SellBellicum Pharmaceuticals, Inc.$97,096,000
-1.6%
4,190,594
-2.2%
0.81%
-19.8%
BCRX SellBiocryst Pharmaceuticals Inc.$94,618,000
-27.4%
10,478,204
-2.2%
0.79%
-40.8%
SellGilead Sciences Inc. 1.625% 5/1/16conv bonds$90,193,000
+1.4%
20,944,000
-2.6%
0.75%
-17.4%
SellMedivation Inc. 2.625% 4/1/17conv bonds$84,927,000
+26.1%
33,889,000
-2.4%
0.71%
+2.8%
MRTX BuyMirati Therapeutics Inc.$82,245,000
+86.6%
2,805,074
+17.9%
0.68%
+52.0%
SellAcorda Therapeutics Inc. Notes 1.75% 6/15/2021conv bonds$60,762,000
-13.0%
59,583,000
-2.2%
0.50%
-29.2%
CERS BuyCerus Corp.$56,517,000
-22.6%
13,553,275
+15.8%
0.47%
-36.9%
VSAR BuyVersartis Inc.$54,694,000
+6.8%
2,977,396
+30.5%
0.46%
-13.0%
XOMA SellXoma Corp.$53,539,000
-11.9%
14,708,613
-13.1%
0.44%
-28.2%
XNPT SellXenoport Inc.$46,341,000
-23.5%
6,508,622
-5.7%
0.38%
-37.7%
ARRY BuyArray Biopharma Inc.$41,705,000
+514.9%
5,658,755
+294.7%
0.35%
+402.9%
SellSalix Pharmaceuticals Inc. 1.5% 3/15/19conv bonds$38,948,000
+42.5%
14,668,000
-2.2%
0.32%
+16.1%
HRTX  Heron Therapeutics, Inc.$37,943,000
+44.6%
2,607,7840.0%0.32%
+17.9%
DBVT  DBV Technologies Inc.sponsored adr$35,489,000
-13.9%
1,519,2290.0%0.30%
-29.9%
INSM BuyInsmed Inc.$32,937,000
+92.2%
1,583,490
+42.9%
0.27%
+56.6%
CPRX BuyCatalyst Pharmaceuticals, Inc.$32,758,000
+64.2%
7,565,462
+12.7%
0.27%
+33.3%
HALO SellHalozyme Therapeutics Inc.$32,104,000
+19.8%
2,248,152
-19.0%
0.27%
-2.2%
TGTX  TG Therapeutics Inc.$31,739,000
-2.3%
2,050,3130.0%0.26%
-20.2%
DSCI SellDerma Sciences Inc.$29,288,000
-11.1%
3,457,841
-2.2%
0.24%
-27.4%
PGNX SellProgenics Pharmaceuticals, Inc.$26,018,000
-22.7%
4,350,808
-2.2%
0.22%
-37.0%
IDRA BuyIdera Pharmaceuticals Inc.$25,842,000
+259.9%
6,965,432
+327.8%
0.22%
+194.5%
ALDR BuyAlder Biopharmaceuticals Inc.$25,385,000
+469.0%
879,581
+473.6%
0.21%
+358.7%
ACOR SellAcorda Therapeutics, Inc.$24,591,000
-20.4%
738,916
-2.2%
0.20%
-34.9%
GILD SellGilead Sciences Inc.$24,532,000
+1.6%
249,995
-2.4%
0.20%
-17.1%
SGMO BuySangamo Biosciences, Inc.$22,023,000
+51.6%
1,404,544
+47.0%
0.18%
+23.6%
NBIX SellNeurocrine Biosciences, Inc.$21,532,000
+73.8%
542,236
-2.2%
0.18%
+42.1%
SellBiomarin Pharmaceuticals Inc. Notes 0.75% 10/15/2018conv bonds$17,970,000
+22.1%
12,228,000
-2.2%
0.15%
-0.7%
KYTH BuyKythera Biopharmaceuticals Inc.$17,766,000
+79.0%
354,265
+23.8%
0.15%
+46.5%
BLUE SellBluebird Bio Inc.$17,703,000
+28.7%
146,581
-2.3%
0.15%
+5.0%
RPRX  Repros Therapeutics Inc.$17,180,000
-13.8%
2,000,0000.0%0.14%
-29.9%
FOMX BuyFoamix Pharmaceuticals Ltd.$16,853,000
+135.3%
1,821,967
+78.3%
0.14%
+91.8%
VNDA SellVanda Pharmaceuticals, Inc.$16,277,000
-74.6%
1,750,230
-60.9%
0.14%
-79.4%
NVAX BuyNovavax Inc.$16,091,000
+121.8%
1,945,687
+59.0%
0.13%
+81.1%
LBIO NewLion Biotechnologies Inc.$16,046,0001,325,000
+100.0%
0.13%
CLVS  Clovis Oncology Inc.$15,041,000
+32.6%
202,6300.0%0.12%
+7.8%
AGIO SellAgios Pharmaceuticals Inc.$14,141,000
-22.8%
149,954
-8.2%
0.12%
-36.9%
OMER SellOmeros Corp.$14,043,000
-12.6%
637,446
-1.6%
0.12%
-28.7%
XNCR BuyXencor Inc.$13,360,000
+40.8%
872,072
+47.5%
0.11%
+14.4%
THLD BuyThreshold Pharmaceuticals Inc.$11,878,000
+73.3%
2,925,519
+35.7%
0.10%
+41.4%
ADHD BuyAlcobra Ltd.$10,077,000
+832.2%
1,789,871
+517.5%
0.08%
+663.6%
AQXP SellAquinox Pharmaceuticals, Inc.$9,763,000
+7.5%
1,187,666
-1.9%
0.08%
-12.9%
MGNX SellMacrogenics, Inc.$9,569,000
-12.5%
305,043
-2.2%
0.08%
-28.6%
AERI  Aerie Pharmaceuticals Inc.$9,382,000
+7.4%
299,3560.0%0.08%
-12.4%
RARE SellUltragenyx Pharmaceuticals Inc.$9,245,000
+40.5%
148,894
-0.7%
0.08%
+14.9%
IMGN NewImmunogen, Inc.$8,945,000999,496
+100.0%
0.07%
PRQR  ProQR Therapeutics NV$8,752,000
+1.0%
400,0000.0%0.07%
-17.0%
OSIR SellOsiris Therapeutics Inc.$8,776,000
+7.5%
499,193
-2.2%
0.07%
-12.0%
ARWR BuyArrowhead Research Corp.$8,728,000
-3.9%
1,290,187
+4.8%
0.07%
-21.5%
SNSS  Sunesis Pharmaceuticals, Inc.$7,840,000
-3.9%
3,200,0000.0%0.06%
-21.7%
LJPC SellLa Jolla Pharmaceuticals, Co.$7,540,000
-3.1%
412,008
-2.3%
0.06%
-20.3%
CNCE SellConcert Pharmaceuticals, Inc.$7,511,000
+11.6%
495,908
-1.9%
0.06%
-10.1%
CLDN SellCelladon Corp$6,947,000
-5.1%
366,806
-2.2%
0.06%
-22.7%
KPTI BuyKaryopharm Therapeutics Inc.$6,642,000
+88.6%
216,990
+130.6%
0.06%
+52.8%
FMI SellFoundation Medicine Inc.$5,978,000
+113.3%
124,255
-1.5%
0.05%
+72.4%
JUNO  Juno Therapeutics Inc.$6,066,000
+16.2%
100,0000.0%0.05%
-5.7%
LGND SellLigand Pharmaceuticals Inc.$5,659,000
+44.9%
73,386
-0.0%
0.05%
+17.5%
RXDX  Ignyta Inc.$5,681,000
+45.3%
571,0000.0%0.05%
+17.5%
TTHI NewTransition Therapeutics, Inc.$5,254,000769,230
+100.0%
0.04%
AMRN NewAmarin Corp. PLCsponsored adr$5,161,0002,205,710
+100.0%
0.04%
STML SellStemline Therapeutics Inc.$4,826,000
-16.5%
333,497
-1.5%
0.04%
-32.2%
CYTR SellCytrx Corp.$4,448,000
+20.2%
1,319,989
-2.2%
0.04%
-2.6%
CMRX SellChimerix Inc.$4,342,000
-37.4%
115,216
-33.2%
0.04%
-49.3%
EPZM BuyEpizyme Inc.$4,366,000
+14.6%
232,481
+15.1%
0.04%
-7.7%
INFI SellInfinity Pharmaceuticals Inc.$4,264,000
-19.1%
305,037
-2.2%
0.04%
-35.2%
DSCO SellDiscovery Laboratories Inc.$4,248,000
+0.3%
3,569,643
-2.3%
0.04%
-18.6%
RCPT  Receptos Inc.$3,941,000
+34.6%
23,9000.0%0.03%
+10.0%
NewArray Biopharma, Inc. Notes 3.0% 6/1/2020conv bonds$3,759,0003,000,000
+100.0%
0.03%
ZFGN NewZafgen, Inc.$3,753,00094,745
+100.0%
0.03%
SAGE  Sage Therapeutics Inc.$3,767,000
+37.2%
75,0000.0%0.03%
+10.7%
ISIS SellIsis Pharmaceuticals, Inc.$3,638,000
-38.8%
57,140
-40.7%
0.03%
-50.8%
ASMB NewAssembly Biosciences, Inc.$3,310,000250,000
+100.0%
0.03%
 Neuroderm Ltd.$3,355,000
-4.4%
250,0000.0%0.03%
-22.2%
LPCN SellLipocine Inc.$3,375,000
+28.3%
489,175
-2.2%
0.03%
+3.7%
BLPH NewBellerophon Therapeutics, Inc.$3,213,000350,000
+100.0%
0.03%
TKMR SellTekmira Pharmaceuticals Corp.$3,153,000
-57.0%
180,582
-62.7%
0.03%
-65.3%
ZGNX SellZogenix, Inc.$3,149,000
-2.2%
2,298,466
-2.2%
0.03%
-21.2%
AUPH SellAurinia Pharmaceuticals, Inc.$3,118,000
+20.0%
711,499
-2.2%
0.03%
-3.7%
IRWD SellIronwood Pharmaceuticals Inc.$2,707,000
-49.0%
169,163
-51.1%
0.02%
-57.4%
BDSI BuyBioDelivery Sciences Intl. Inc.$2,686,000
+6.4%
255,866
+21.8%
0.02%
-15.4%
 Protalix Biotherapeutics, Inc. Notes 4.5% 9/15/18conv bonds$2,612,000
-1.2%
3,500,0000.0%0.02%
-18.5%
AFMD  Affimed N.V.$2,520,000
+1.6%
400,0000.0%0.02%
-16.0%
ITCI NewIntra Cellular Therapies Inc.$2,487,000104,166
+100.0%
0.02%
ASPX NewAuspex Pharmaceuticals, Inc.$2,507,00025,000
+100.0%
0.02%
MSTX SellMast Therapeutics, Inc.$2,283,000
-14.6%
4,707,464
-1.4%
0.02%
-29.6%
ENTA  Enanta Pharmaceuticals Inc.$2,307,000
-39.8%
75,3570.0%0.02%
-51.3%
ACHN SellAchillion Pharmaceuticals, Inc.$2,112,000
-60.7%
214,237
-51.1%
0.02%
-67.3%
VTAE NewVitae Pharmaceuticals Inc.$2,197,000187,597
+100.0%
0.02%
ZIOP SellZiopharm Oncology Inc.$2,038,000
+107.5%
189,259
-2.3%
0.02%
+70.0%
BOTA SellBiota Pharmaceuticals Inc.$1,985,000
-19.9%
863,184
-22.0%
0.02%
-32.0%
PRTO  Proteon Therapeutics, Inc.$2,011,000
+11.8%
172,9170.0%0.02%
-5.6%
PTN  Palatin Technologies Inc.$2,091,000
+39.7%
2,050,0000.0%0.02%
+13.3%
MRNS SellMarinus Pharmaceuticals Inc.$1,798,000
-16.8%
200,000
-2.2%
0.02%
-31.8%
ASND NewAscendis Pharma SAsponsored adr$1,735,000100,000
+100.0%
0.01%
OPHT SellOphthotech Corp.$1,659,000
+0.5%
35,649
-3.1%
0.01%
-17.6%
MDWD  Mediwound Ltd.$1,629,000
+8.7%
225,0000.0%0.01%
-6.7%
CLLS NewCellectis SAsponsored adr$1,729,00050,000
+100.0%
0.01%
DERM  Dermira Inc.$1,535,000
-15.2%
100,0000.0%0.01%
-27.8%
OSUR SellOrasure Technologies Inc.$1,500,000
-36.9%
229,397
-2.2%
0.01%
-50.0%
ALDX NewAldeyra Therapeutics, Inc.$1,446,000142,000
+100.0%
0.01%
RIGL SellRigel Pharmaceuticals Inc.$1,275,000
+16.5%
357,187
-25.9%
0.01%0.0%
ALNY SellAlnylam Pharmaceuticals, Inc.$1,184,000
+5.2%
11,340
-2.2%
0.01%
-9.1%
LOXO  Loxo Oncology Inc.$1,245,000
+6.0%
100,0000.0%0.01%
-16.7%
XLRN  Acceleron Pharma Inc.$1,095,000
-2.3%
28,7650.0%0.01%
-18.2%
AKAOQ  Achaogen Inc.$976,000
-25.2%
100,0000.0%0.01%
-38.5%
SNTA SellSynta Pharmaceuticals Corp.$949,000
-28.4%
489,053
-2.2%
0.01%
-42.9%
OHRP NewOhr Pharmaceuticals, Inc.$941,000370,370
+100.0%
0.01%
QURE SellUniQure N.V.$730,000
+60.8%
30,000
-2.2%
0.01%
+20.0%
FPRX SellFive Prime Therapeutics Inc.$440,000
-17.8%
19,247
-2.9%
0.00%
-20.0%
AEGR NewAegerion Pharmaceuticals, Inc.$374,00014,300
+100.0%
0.00%
CCXI SellChemocentryx Inc.$370,000
+8.2%
49,064
-1.9%
0.00%0.0%
SellAptose Biosciences, Inc.$181,000
-93.6%
33,397
-93.0%
0.00%
-93.1%
CYCCP  Cyclacel Pharmaceuticals Inc.pfd conv ex 6%$86,000
+4.9%
13,2530.0%0.00%0.0%
BIOD NewBiodel Inc.$36,00030,179
+100.0%
0.00%
BTXWS SellBiotime Inc.warrants$40,000
+81.8%
20,084
-2.1%
0.00%
AST ExitAsterias Biotherapeutics, Inc.$0-16,775
-100.0%
-0.00%
TSRO ExitTesaro Inc.$0-31,218
-100.0%
-0.01%
GERN ExitGeron Corp.$0-402,629
-100.0%
-0.01%
SGYPQ ExitSynergy Pharmaceuticals$0-973,245
-100.0%
-0.03%
CLTX ExitCelsus Therapeuticssponsored adr ne$0-673,887
-100.0%
-0.03%
FOLD ExitAmicus Therapeutics$0-481,697
-100.0%
-0.04%
MNKKQ ExitMallinckrodt PUB LTD CO$0-46,666
-100.0%
-0.05%
QLTI ExitQLT Inc.$0-1,535,863
-100.0%
-0.06%
SLXP ExitSalix Pharmaceuticals$0-635,321
-100.0%
-0.74%
AVNR ExitAvanir Pharmaceuticals$0-38,513,713
-100.0%
-6.66%
Original filings

The following EDGAR filing(s) were analyzed to create this report:

  • View 13F-HR filed 2015-05-15
Signatures

The EDGAR filing(s) were signed by:

About Baker Brothers Advisors

Baker Brothers Advisors is a well-known investment management firm that specializes in the healthcare sector. The firm was founded in 2000 by brothers Julian and Felix Baker, who are both highly respected in the industry. Julian Baker is the CEO of the firm, while Felix Baker serves as a managing partner.

Baker Brothers Advisors has a reputation for investing in innovative healthcare companies that have the potential to make a significant impact on the industry. The firm has a long-term investment approach and is known for taking large positions in companies that it believes in. Some of the firm's most successful investments include companies such as Pharmacyclics, which was acquired by AbbVie for $21 billion, and Ariad Pharmaceuticals, which was acquired by Takeda for $5.2 billion.

The firm's investment strategy is led by its Chief Investment Officer, Dr. Robert Duggan, who has a background in both medicine and finance. Dr. Duggan is known for his ability to identify promising healthcare companies and for his willingness to take risks on early-stage companies.

Overall, Baker Brothers Advisors is a highly respected investment management firm that has a proven track record of success in the healthcare sector. While the firm's investment approach may not be suitable for all investors, those who are interested in the healthcare sector may want to consider Baker Brothers Advisors as a potential investment opportunity.

It's important to note that this information is for educational purposes only and has not been fact-checked. As with any investment, it's important to do your own research and consult with a financial advisor before making any investment decisions.

Top long-term holdings
NameQuarters ownedLatest quarter ownedMax weighting
Incyte Corporation42Q3 202337.6%
ACADIA Pharmaceuticals Inc.42Q3 202310.9%
Biomarin Pharmaceuticals Inc.42Q3 20235.9%
BioCryst Pharmaceuticals, Inc.42Q3 20231.7%
Cerus Corporation42Q3 20230.9%
Insmed Incorporated42Q3 20230.4%
Mirati Therapeutics, Inc.41Q3 20231.8%
Bluebird Bio Inc.41Q3 20230.3%
Heron Therapeutics, Inc.39Q3 20231.5%
ChemoCentryx, Inc.37Q3 20220.6%

View Baker Brothers Advisors's complete holdings history.

Latest significant ownerships (13-D/G)
Baker Brothers Advisors Q1 2015 significant holdings filed using form 13D/G when ownership exceeds 5% of a company's total stock issue.
FiledShares Percentage
Neoleukin Therapeutics, Inc.August 17, 20239,469,83820.0%
Mereo Biopharma Group plcAugust 10, 202314,604,3912.2%
Verastem, Inc.August 10, 2023? ?
TScan Therapeutics, Inc.June 02, 20232,793,9386.5%
ACADIA PHARMACEUTICALS INCMay 24, 202343,084,28026.5%
INCYTE CORPMarch 15, 202336,280,96716.3%
Seagen Inc.March 13, 202346,985,65625.1%
Talis Biomedical CorpMarch 10, 202337,569,14066.2%
Aeglea BioTherapeutics, Inc.February 14, 20236,384,0139.9%
Merus N.V.February 14, 2023? ?

View Baker Brothers Advisors's complete significant-ownership history.

Latest filings
TypeFiled
42024-04-23
SC 13D/A2024-04-23
42024-04-22
32024-04-18
SC 13D2024-04-18
32024-04-01
42024-04-01
42024-04-01
42024-04-01
SC 13D2024-04-01

View Baker Brothers Advisors's complete filings history.

Compare quarters

Export Baker Brothers Advisors's holdings