Baker Brothers Advisors - Q3 2015 holdings

$10.8 Billion is the total value of Baker Brothers Advisors's 133 reported holdings in Q3 2015. The portfolio turnover from Q2 2015 to Q3 2015 was 21.4% .

 Value Shares↓ Weighting
INCY BuyIncyte Corporation$2,148,673,000
+38.7%
19,474,969
+31.0%
19.85%
+46.1%
SGEN BuySeattle Genetics, Inc.$1,389,307,000
-7.0%
36,029,746
+16.7%
12.84%
-2.1%
ALXN  Alexion Pharmaceuticals, Inc.$1,023,197,000
-13.5%
6,542,5990.0%9.45%
-8.9%
ABBV  AbbVie Inc.$782,064,000
-19.0%
14,373,5380.0%7.22%
-14.7%
ACAD  ACADIA Pharmaceuticals Inc.$677,321,000
-21.0%
20,481,4420.0%6.26%
-16.8%
 Incyte Corporation Notes 1.25% 11/15/2020 144Aconv bonds$598,696,000
+5.4%
274,500,0000.0%5.53%
+11.1%
 Incyte Corporation Notes 0.375% 11/15/2018 144Aconv bonds$559,636,000
+5.7%
259,000,0000.0%5.17%
+11.3%
ANAC BuyAnacor Pharmaceuticals, Inc.$486,779,000
+73.4%
4,135,412
+14.1%
4.50%
+82.7%
BMRN SellBioMarin Pharmaceutical Inc.$429,321,000
-23.4%
4,076,353
-0.5%
3.97%
-19.3%
GHDX BuyGenomic Health Inc.$289,011,000
-23.9%
13,658,328
+0.0%
2.67%
-19.8%
NewClovis Oncology Inc. 2.5% 9/15/2021conv bonds$215,311,000129,300,000
+100.0%
1.99%
DBVT BuyDBV Technologies S.A.sponsored adr$194,393,000
+250.6%
5,462,019
+193.3%
1.80%
+269.5%
BCRX BuyBioCryst Pharmaceuticals, Inc.$160,856,000
-6.9%
14,110,179
+21.9%
1.49%
-2.0%
DYAX SellDyax Corp.$144,349,000
-31.3%
7,561,480
-4.6%
1.33%
-27.6%
 BioMarin Pharmaceutical Inc. Notes 1.875% 4/23/2017conv bonds$115,619,000
-22.9%
22,379,0000.0%1.07%
-18.8%
MRTX BuyMirati Therapeutics, Inc.$101,714,000
+15.2%
2,955,074
+5.3%
0.94%
+21.4%
AQXP BuyAquinox Pharmaceuticals, Inc.$94,935,000
+1042.4%
6,747,332
+463.5%
0.88%
+1101.4%
 Gilead, Inc. 1.625% 5/1/16conv bonds$90,326,000
-16.3%
20,944,0000.0%0.84%
-11.8%
HRTX BuyHeron Therapeutics, Inc.$70,950,000
-18.9%
2,907,784
+3.6%
0.66%
-14.5%
CERS  Cerus Corporation$61,532,000
-12.5%
13,553,2750.0%0.57%
-7.9%
BLCM  Bellicum Pharmaceuticals, Inc.$60,889,000
-31.7%
4,190,5940.0%0.56%
-28.0%
 Acorda Therapeutics, Inc. Notes 1.75% 6/15/2021conv bonds$54,123,000
-9.9%
59,583,0000.0%0.50%
-5.1%
ONCE  Spark Therapeutics, Inc.$52,679,000
-30.8%
1,262,3820.0%0.49%
-27.0%
NVTA  Invitae Corporation$47,327,000
-51.5%
6,554,9670.0%0.44%
-48.9%
VSAR SellVersartis, Inc.$37,378,000
-28.5%
3,241,783
-5.7%
0.34%
-24.8%
IMGN BuyImmunoGen, Inc.$34,061,000
+2.1%
3,548,040
+52.9%
0.32%
+7.5%
NBIX BuyNeurocrine Biosciences, Inc.$29,872,000
+15.3%
750,739
+38.5%
0.28%
+21.6%
INSM  Insmed, Inc.$29,405,000
-24.0%
1,583,4900.0%0.27%
-19.8%
ACOR BuyAcorda Therapeutics, Inc.$29,078,000
+18.1%
1,096,876
+48.4%
0.27%
+24.5%
MDVN NewMedivation, Inc.$28,039,000659,752
+100.0%
0.26%
HALO  Halozyme Therapeutics, Inc.$25,934,000
-40.5%
1,931,0570.0%0.24%
-37.2%
PGNX  Progenics Pharmaceuticals, Inc.$24,887,000
-23.3%
4,350,8080.0%0.23%
-19.3%
GILD  Gilead Sciences, Inc.$24,547,000
-16.1%
249,9950.0%0.23%
-11.7%
ITCI BuyIntra-Cellular Therapies, Inc.$24,391,000
+632.9%
609,166
+484.8%
0.22%
+675.9%
ZGNX NewZogenix, Inc.$24,278,0001,798,365
+100.0%
0.22%
NewExelisis, Inc. Notes 4.25% 8/15/2019conv bonds$23,988,00020,000,000
+100.0%
0.22%
LIFE  aTyr Pharma Inc.$23,958,000
-44.6%
2,335,1250.0%0.22%
-41.7%
IDRA BuyIdera Pharmaceuticals, Inc.$23,370,000
-9.6%
6,976,162
+0.1%
0.22%
-4.8%
XNPT  XenoPort, Inc.$22,585,000
-43.4%
6,508,6220.0%0.21%
-40.3%
CPRX  Catalyst Pharmaceuticals, Inc.$22,007,000
-27.4%
7,335,6920.0%0.20%
-23.7%
SGMO BuySangamo BioSciences, Inc.$21,183,000
-40.9%
3,755,876
+16.2%
0.20%
-37.6%
TGTX  TG Therapeutics, Inc.$20,200,000
-39.2%
2,003,9910.0%0.19%
-36.0%
NewAegerion Pharmaceuticals, Inc. Notes 2.0% 8/15/2019conv bonds$19,873,00026,517,000
+100.0%
0.18%
ARRY SellArray BioPharma Inc.$19,657,000
-50.3%
4,310,666
-21.4%
0.18%
-47.6%
CLVS  Clovis Oncology, Inc.$18,634,000
+4.6%
202,6300.0%0.17%
+10.3%
ALDR SellAlder Biopharmaceuticals Inc.$16,820,000
-64.4%
513,439
-42.4%
0.16%
-62.6%
DSCI  Derma Sciences, Inc.$16,286,000
-34.2%
3,457,8410.0%0.15%
-30.9%
 BioMarin Pharmaceutical Inc. Notes 0.75% 10/15/2018conv bonds$15,899,000
-16.1%
12,228,0000.0%0.15%
-11.4%
NVAX BuyNovavax, Inc.$15,524,000
-28.4%
2,195,687
+12.8%
0.14%
-24.7%
FOMX  Foamix Pharmaceuticals Ltd.$15,004,000
-28.5%
2,046,9670.0%0.14%
-24.5%
GLPG  Galapagos NV ADRspon adr$15,033,000
-21.0%
369,2760.0%0.14%
-16.8%
RPRX  Repros Therapeutics Inc.$14,533,000
+3.9%
1,955,9440.0%0.13%
+8.9%
PRQR  ProQR Therapeutics N.V.$14,400,000
-12.6%
988,2990.0%0.13%
-8.3%
ACHN BuyAchillion Pharmaceuticals, Inc.$13,820,000
+2.4%
2,000,000
+31.3%
0.13%
+8.5%
ZFGN BuyZafgen, Inc.$12,472,000
+25.2%
390,346
+35.7%
0.12%
+32.2%
BLUE Sellbluebird bio, Inc.$12,072,000
-52.6%
141,105
-6.6%
0.11%
-49.8%
RARE  Ultragenyx Pharmaceuticals$11,932,000
-5.9%
123,8940.0%0.11%
-0.9%
THLD  Threshold Pharmaceuticals, Inc.$11,907,000
+0.7%
2,925,5190.0%0.11%
+5.8%
LJPC  La Jolla Pharmaceutical Company$11,450,000
+13.4%
412,0080.0%0.11%
+19.1%
XNCR  Xencor, Inc.$10,665,000
-44.3%
872,0720.0%0.10%
-41.1%
LBIO  Lion Biotechnologies, Inc.$10,468,000
-37.2%
1,817,4290.0%0.10%
-33.6%
ADHD SellAlcobra Ltd.$9,905,000
-15.4%
1,639,871
-8.4%
0.09%
-10.7%
AKTX NewAkari Therapeutics PLC ADRsponsored adr$9,499,000395,882
+100.0%
0.09%
CNCE  Concert Pharmaceuticals, Inc.$9,308,000
+26.1%
495,9080.0%0.09%
+32.3%
OSIR  Osiris Therapeutics, Inc.$9,220,000
-5.1%
499,1930.0%0.08%0.0%
GBT NewGlobal Blood Therapeutics, Inc.$8,432,000200,000
+100.0%
0.08%
ASND BuyAscendis Pharma A/Ssponsored adr$7,709,000
+336.0%
435,540
+335.5%
0.07%
+343.8%
MGNX BuyMacroGenics, Inc.$7,449,000
-35.7%
347,776
+14.0%
0.07%
-32.4%
AGIO  Agios Pharmaceuticals, Inc.$7,059,000
-36.5%
100,0000.0%0.06%
-33.0%
DERM BuyDermira, Inc.$6,419,000
+265.8%
275,000
+175.0%
0.06%
+293.3%
AIMT NewAimmune Therapeutics, Inc.$6,330,000250,000
+100.0%
0.06%
LGND  Ligand Pharmaceuticals Incorporated$6,286,000
-15.1%
73,3860.0%0.06%
-10.8%
BuyNeuroDerm Ltd.$6,304,000
+64.3%
305,000
+22.0%
0.06%
+70.6%
ECYT NewEndocyte, Inc.$6,213,0001,356,552
+100.0%
0.06%
ARWR  Arrowhead Research Corp.$5,815,000
-19.4%
1,009,5090.0%0.05%
-14.3%
AERI  Aerie Pharmaceuticals, Inc.$5,311,000
+0.5%
299,3560.0%0.05%
+6.5%
RXDX  Ignyta, Inc.$5,013,000
-41.8%
571,0000.0%0.05%
-39.5%
TRVN NewTrevena, Inc.$4,658,000450,000
+100.0%
0.04%
SAGE  Sage Therapeutics, Inc.$4,444,000
-42.0%
105,0000.0%0.04%
-38.8%
CMRX  Chimerix, Inc.$4,401,000
-17.3%
115,2160.0%0.04%
-12.8%
AMRN  Amarin Corporation plcspons adr new$4,257,000
-21.5%
2,205,7100.0%0.04%
-18.8%
DNAI NewPronai Therapeutics, Inc.$4,104,000200,000
+100.0%
0.04%
CRIS BuyCuris, Inc.$4,039,000
+13.2%
1,999,303
+85.5%
0.04%
+19.4%
PRTO BuyProteon Therapeutics, Inc.$3,820,000
+21.0%
274,617
+55.4%
0.04%
+25.0%
MCRB  Seres Therapeutics, Inc.$3,705,000
-28.6%
125,0000.0%0.03%
-26.1%
OMER SellOmeros Corporation$3,685,000
-78.8%
336,226
-65.1%
0.03%
-77.6%
NBRV NewNabriva Therapeutics AGsponsored adr$3,325,000350,000
+100.0%
0.03%
JUNO  Juno Therapeutics, Inc.$3,255,000
-23.7%
80,0000.0%0.03%
-18.9%
CYTR  CytRx Corporation$3,128,000
-36.3%
1,319,9890.0%0.03%
-32.6%
EPZM  Epizyme, Inc.$2,990,000
-46.4%
232,4810.0%0.03%
-42.9%
 Array BioPharma Inc. Notes 3.0% 6/1/2020conv bonds$2,921,000
-22.7%
3,000,0000.0%0.03%
-18.2%
STML  Stemline Therapeutics, Inc.$2,945,000
-25.0%
333,4970.0%0.03%
-20.6%
NTRA NewNatera, Inc.$2,713,000250,000
+100.0%
0.02%
ENTA  Enanta Pharmaceuticals, Inc.$2,723,000
-19.7%
75,3570.0%0.02%
-16.7%
MSTX  Mast Therapeutics, Inc.$2,730,000
+18.3%
4,707,4640.0%0.02%
+25.0%
SNSS  Sunesis Pharmaceuticals, Inc.$2,592,000
-73.1%
3,200,0000.0%0.02%
-71.4%
AFMD  Affimed N.V.$2,468,000
-54.2%
400,0000.0%0.02%
-51.1%
 Protalix BioTherapeutics, Inc. Notes 4.5% 9/15/18conv bonds$2,450,000
-6.0%
3,423,0000.0%0.02%0.0%
ASMB  Assembly Biosciences, Inc.$2,390,000
-50.4%
250,0000.0%0.02%
-47.6%
KPTI  Karyopharm Therapeutics Inc.$2,285,000
-61.3%
216,9900.0%0.02%
-59.6%
ISIS  Isis Pharmaceuticals, Inc.$2,310,000
-29.7%
57,1400.0%0.02%
-27.6%
VTAE  Vitae Pharmaceuticals, Inc.$2,065,000
-23.5%
187,5970.0%0.02%
-20.8%
AUPH  Aurinia Pharmaceuticals Inc.$1,999,000
-6.2%
711,4990.0%0.02%
-5.3%
BLPH BuyBellerophon Therapeutics, Inc.$1,832,000
-34.0%
352,928
+0.8%
0.02%
-29.2%
DVAX NewDynavax Technologies Corporation$1,841,00075,000
+100.0%
0.02%
IMDZ  Immune Design Corp.$1,817,000
-40.9%
148,9370.0%0.02%
-37.0%
IRWD  Ironwood Pharmaceuticals, Inc.$1,763,000
-13.6%
169,1630.0%0.02%
-11.1%
LOXO  Loxo Oncology, Inc.$1,748,000
-3.1%
100,0000.0%0.02%0.0%
MDWD  MediWound Ltd.$1,717,000
+7.9%
225,0000.0%0.02%
+14.3%
MRNS  Marinus Pharmaceuticals, Inc.$1,668,000
-28.1%
200,0000.0%0.02%
-25.0%
PTN  Palatin Technologies, Inc.$1,661,000
-9.0%
2,050,0000.0%0.02%
-6.2%
OPHT  Ophthotech Corporation$1,444,000
-22.2%
35,6490.0%0.01%
-18.8%
CLLS  Cellectis S.A.sponsored ads$1,318,000
-26.9%
50,0000.0%0.01%
-25.0%
TENX BuyTenax Therapeutics Inc.$1,260,000
-3.9%
420,000
+18.2%
0.01%
+9.1%
BDSI  BioDelivery Sciences International, Inc.$1,168,000
-30.1%
210,0210.0%0.01%
-26.7%
ADAP  Adaptimmune Therapeutics plc ADRsponds adr$1,197,000
-34.7%
100,0000.0%0.01%
-31.2%
DSCO  Discovery Laboratories, Inc.$1,071,000
-55.9%
3,569,6430.0%0.01%
-52.4%
ABUS NewArbutus Biopharma Corporation$1,100,000180,582
+100.0%
0.01%
OHRP  Ohr Pharmaceuticals, Inc.$1,022,000
+9.9%
370,3700.0%0.01%
+12.5%
RTTR  Ritter Pharmaceuticals, Inc.$820,000
-53.9%
400,0000.0%0.01%
-50.0%
NewTrillium Therapeutics, Inc.$821,00063,014
+100.0%
0.01%
ALDX  Aldeyra Therapeutics, Inc.$828,000
-24.9%
142,0000.0%0.01%
-20.0%
ALNY  Alnylam Pharmaceuticals, Inc.$911,000
-33.0%
11,3400.0%0.01%
-33.3%
XLRN  Acceleron Pharma, Inc.$716,000
-21.3%
28,7650.0%0.01%
-12.5%
QURE  UniQure B.V.$614,000
-24.2%
30,0000.0%0.01%
-14.3%
AKAOQ  Achaogen, Inc.$576,000
-4.5%
100,0000.0%0.01%0.0%
FMI  Foundation Medicine, Inc.$385,000
-45.5%
20,8920.0%0.00%
-33.3%
CCXI  ChemoCentryx, Inc.$297,000
-26.5%
49,0640.0%0.00%
-25.0%
FPRX  Five Prime Therapeutics, Inc.$296,000
-38.1%
19,2470.0%0.00%
-25.0%
SGYPQ NewSynergy Pharmaceuticals, Inc.$356,00067,100
+100.0%
0.00%
CYCCP  Cyclacel Pharmaceuticals, Inc. Pfd. Conv. Ex 6%pfd conv ex 6%$62,000
-27.1%
13,2530.0%0.00%0.0%
 Aptose Biosciences, Inc.$144,000
-15.3%
33,3970.0%0.00%0.0%
BTXWS  BioTime, Inc. Rights*w exp 10/01/201$17,000
-26.1%
20,0840.0%0.00%
BOTA ExitBiota Pharmaceuticals, Inc.$0-830,440
-100.0%
-0.02%
TKMR ExitTekmira Pharmaceuticals Corp.$0-180,582
-100.0%
-0.02%
ZIOP ExitZIOPHARM Oncology, Inc.$0-189,259
-100.0%
-0.02%
RCPT ExitReceptos, Inc.$0-23,900
-100.0%
-0.04%
VNDA ExitVanda Pharmaceuticals Inc.$0-409,881
-100.0%
-0.05%
ZGNX ExitZogenix, Inc.$0-10,028,564
-100.0%
-0.15%
KYTH ExitKythera Biopharmaceuticals, Inc.$0-387,741
-100.0%
-0.26%
XOMA ExitXOMA Corporation$0-14,683,513
-100.0%
-0.50%
ExitMedivation, Inc. 2.625% 4/1/17conv bonds$0-33,889,000
-100.0%
-0.66%
ExitIncyte Corporation Notes 4.75% 10/1/2015 144Aconv bonds$0-40,446,000
-100.0%
-4.20%
Original filings

The following EDGAR filing(s) were analyzed to create this report:

  • View 13F-HR filed 2015-11-16
Signatures

The EDGAR filing(s) were signed by:

About Baker Brothers Advisors

Baker Brothers Advisors is a well-known investment management firm that specializes in the healthcare sector. The firm was founded in 2000 by brothers Julian and Felix Baker, who are both highly respected in the industry. Julian Baker is the CEO of the firm, while Felix Baker serves as a managing partner.

Baker Brothers Advisors has a reputation for investing in innovative healthcare companies that have the potential to make a significant impact on the industry. The firm has a long-term investment approach and is known for taking large positions in companies that it believes in. Some of the firm's most successful investments include companies such as Pharmacyclics, which was acquired by AbbVie for $21 billion, and Ariad Pharmaceuticals, which was acquired by Takeda for $5.2 billion.

The firm's investment strategy is led by its Chief Investment Officer, Dr. Robert Duggan, who has a background in both medicine and finance. Dr. Duggan is known for his ability to identify promising healthcare companies and for his willingness to take risks on early-stage companies.

Overall, Baker Brothers Advisors is a highly respected investment management firm that has a proven track record of success in the healthcare sector. While the firm's investment approach may not be suitable for all investors, those who are interested in the healthcare sector may want to consider Baker Brothers Advisors as a potential investment opportunity.

It's important to note that this information is for educational purposes only and has not been fact-checked. As with any investment, it's important to do your own research and consult with a financial advisor before making any investment decisions.

Top long-term holdings
NameQuarters ownedLatest quarter ownedMax weighting
Incyte Corporation42Q3 202337.6%
ACADIA Pharmaceuticals Inc.42Q3 202310.9%
Biomarin Pharmaceuticals Inc.42Q3 20235.9%
BioCryst Pharmaceuticals, Inc.42Q3 20231.7%
Cerus Corporation42Q3 20230.9%
Insmed Incorporated42Q3 20230.4%
Mirati Therapeutics, Inc.41Q3 20231.8%
Bluebird Bio Inc.41Q3 20230.3%
Heron Therapeutics, Inc.39Q3 20231.5%
ChemoCentryx, Inc.37Q3 20220.6%

View Baker Brothers Advisors's complete holdings history.

Latest significant ownerships (13-D/G)
Baker Brothers Advisors Q3 2015 significant holdings filed using form 13D/G when ownership exceeds 5% of a company's total stock issue.
FiledShares Percentage
Neoleukin Therapeutics, Inc.August 17, 20239,469,83820.0%
Mereo Biopharma Group plcAugust 10, 202314,604,3912.2%
Verastem, Inc.August 10, 2023? ?
TScan Therapeutics, Inc.June 02, 20232,793,9386.5%
ACADIA PHARMACEUTICALS INCMay 24, 202343,084,28026.5%
INCYTE CORPMarch 15, 202336,280,96716.3%
Seagen Inc.March 13, 202346,985,65625.1%
Talis Biomedical CorpMarch 10, 202337,569,14066.2%
Aeglea BioTherapeutics, Inc.February 14, 20236,384,0139.9%
Merus N.V.February 14, 2023? ?

View Baker Brothers Advisors's complete significant-ownership history.

Latest filings
TypeFiled
42024-04-23
SC 13D/A2024-04-23
42024-04-22
32024-04-18
SC 13D2024-04-18
32024-04-01
42024-04-01
42024-04-01
42024-04-01
SC 13D2024-04-01

View Baker Brothers Advisors's complete filings history.

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