| MOODY ALDRICH PARTNERS LLC | 140,170 | $7,145,867 | 1.35% |
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| SECTORAL ASSET MANAGEMENT INC | 121,230 | $6,180,305 | 1.20% |
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| Orbimed Advisors | 1,007,148 | $51,344,405 | 1.09% |
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| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,323,884 | $67,491,606 | 0.88% |
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| Ikarian Capital, LLC | 142,417 | $7,260,419 | 0.87% |
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| Eversept Partners, LP | 190,430 | $9,708,121 | 0.82% |
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| Artia Global Partners LP | 38,555 | $1,965,534 | 0.82% |
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| China Universal Asset Management Co., Ltd. | 42,410 | $2,162 | 0.63% |
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| FRED ALGER MANAGEMENT, LLC | 2,093,305 | $106,716,689 | 0.61% |
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| Polar Asset Management Partners Inc. | 325,579 | $16,598,017 | 0.37% |
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| Eventide Asset Management | 393,000 | $20,035,140 | 0.36% |
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| Affinity Asset Advisors, LLC | 25,000 | $1,274,500 | 0.36% |
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| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,003,916 | $51,179,638 | 0.35% |
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| ADVISORY RESEARCH INC | 41,255 | $2,103,180 | 0.29% |
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| Lisanti Capital Growth, LLC | 34,970 | $1,782,771 | 0.28% |
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| HighVista Strategies LLC | 11,248 | $573,423 | 0.26% |
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| JANUS HENDERSON GROUP PLC | 7,060,588 | $359,911,596 | 0.24% |
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| Woodline Partners LP | 380,613 | $19,403,651 | 0.23% |
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| EAM Investors, LLC | 17,289 | $881,393 | 0.17% |
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| Campbell & CO Investment Adviser LLC | 26,342 | $1,342,915 | 0.16% |
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