Orbimed Advisors - Q3 2023 holdings

$4.71 Billion is the total value of Orbimed Advisors's 128 reported holdings in Q3 2023. The portfolio turnover from Q2 2023 to Q3 2023 was 35.7% .

 Value Shares↓ Weighting
SVA  SINOVAC BIOTECH LTD$340,000,0000.0%2,718,7350.0%7.22%
+17.2%
BSX SellBOSTON SCIENTIFIC CORP$174,599,040
-4.5%
3,306,800
-2.2%
3.71%
+12.0%
HUM SellHUMANA INC$166,633,100
+6.9%
342,500
-1.8%
3.54%
+25.3%
ISRG SellINTUITIVE SURGICAL INC$145,852,710
-31.3%
499,000
-19.6%
3.10%
-19.4%
BIIB  BIOGEN INC$143,103,168
-9.8%
556,8000.0%3.04%
+5.8%
BMRN  BIOMARIN PHARMACEUTICAL INC$142,913,781
+2.1%
1,615,2100.0%3.04%
+19.7%
 ENLIVEN THERAPEUTICS INC$122,917,297
-33.1%
8,998,3380.0%2.61%
-21.5%
MRK NewMERCK & CO INC$108,612,2501,055,000
+100.0%
2.31%
 DISC MEDICINE INC$106,627,546
+5.8%
2,269,6370.0%2.26%
+24.0%
LLY  ELI LILLY & CO$99,906,180
+14.5%
186,0000.0%2.12%
+34.2%
IONS  IONIS PHARMACEUTICALS INC$98,408,520
+10.6%
2,169,5000.0%2.09%
+29.6%
SWTX SellSPRINGWORKS THERAPEUTICS INC$91,753,755
-16.3%
3,968,588
-5.0%
1.95%
-1.8%
UTHR  UNITED THERAPEUTICS CORP DEL$90,777,153
+2.3%
401,9000.0%1.93%
+19.9%
CRNX SellCRINETICS PHARMACEUTICALS IN$86,129,241
+21.0%
2,896,074
-26.7%
1.83%
+41.9%
MRTX BuyMIRATI THERAPEUTICS INC$85,336,218
+158.5%
1,959,050
+114.4%
1.81%
+203.2%
BAX SellBAXTER INTL INC$84,533,826
-45.0%
2,239,900
-33.6%
1.80%
-35.5%
EWTX  EDGEWISE THERAPEUTICS INC$83,469,918
-26.1%
14,567,1760.0%1.77%
-13.3%
THC BuyTENET HEALTHCARE CORP$80,675,716
+3.2%
1,224,400
+27.5%
1.71%
+21.0%
XTNT  XTANT MED HLDGS INC$80,426,051
+18.3%
73,114,5920.0%1.71%
+38.6%
EVH  EVOLENT HEALTH INCcl a$78,848,059
-10.1%
2,895,6320.0%1.68%
+5.3%
SYK SellSTRYKER CORPORATION$73,509,630
-11.2%
269,000
-0.9%
1.56%
+4.1%
TMO SellTHERMO FISHER SCIENTIFIC INC$72,787,246
-14.3%
143,800
-11.7%
1.55%
+0.5%
BuyAPOLLOMICS INC$67,386,163
+1675.0%
17,993,635
+2615.8%
1.43%
+1973.9%
CI BuyTHE CIGNA GROUP$66,225,205
+46.6%
231,500
+43.8%
1.41%
+71.8%
SRPT SellSAREPTA THERAPEUTICS INC$64,149,624
-14.3%
529,200
-19.1%
1.36%
+0.4%
VRNA  VERONA PHARMA PLCsponsored ads$61,577,781
-22.9%
3,777,7780.0%1.31%
-9.6%
NewRAYZEBIO INC$58,228,5802,622,909
+100.0%
1.24%
VRTX  VERTEX PHARMACEUTICALS INC$57,516,196
-1.2%
165,4000.0%1.22%
+15.8%
 ACELYRIN INC$54,168,491
-51.3%
5,326,3020.0%1.15%
-42.9%
 R1 RCM INC$51,855,870
-18.3%
3,441,0000.0%1.10%
-4.2%
PCVX  VAXCYTE INC$51,344,405
+2.1%
1,007,1480.0%1.09%
+19.8%
ABBV NewABBVIE INC$49,189,800330,000
+100.0%
1.04%
SIBN  SI-BONE INC$48,693,358
-21.3%
2,292,5310.0%1.03%
-7.8%
KROS  KEROS THERAPEUTICS INC$48,289,720
-20.7%
1,514,7340.0%1.03%
-7.0%
APLS BuyAPELLIS PHARMACEUTICALS INC$47,949,420
-42.2%
1,260,500
+38.5%
1.02%
-32.2%
BuyTHESEUS PHARMACEUTICALS INC$47,649,584
-70.4%
17,713,600
+2.8%
1.01%
-65.3%
NBIX SellNEUROCRINE BIOSCIENCES INC$46,788,750
+1.5%
415,900
-14.9%
0.99%
+18.9%
ALPN  ALPINE IMMUNE SCIENCES INC$46,734,228
+11.4%
4,081,5920.0%0.99%
+30.7%
BuyPRELUDE THERAPEUTICS INCnonvoting$45,127,757
-32.0%
12,048,773
+1.3%
0.96%
-20.2%
CMPX  COMPASS THERAPEUTICS INC$44,054,815
-38.1%
22,362,8500.0%0.94%
-27.4%
NTRA SellNATERA INC$40,735,709
-14.0%
920,581
-5.4%
0.86%
+0.8%
PMVP  PMV PHARMACEUTICALS INC$40,297,293
-1.9%
6,563,0770.0%0.86%
+15.1%
RPTX  REPARE THERAPEUTICS INC$40,135,655
+14.2%
3,322,4880.0%0.85%
+33.9%
SCPH  SCPHARMACEUTICALS INC$39,583,839
-30.1%
5,559,5280.0%0.84%
-18.0%
NPCE  NEUROPACE INC$39,039,494
+116.7%
4,012,2810.0%0.83%
+154.3%
TERN  TERNS PHARMACEUTICALS INC$38,324,249
-42.5%
7,619,1350.0%0.81%
-32.6%
MDGL SellMADRIGAL PHARMACEUTICALS INC$36,993,246
-50.2%
253,309
-21.2%
0.79%
-41.6%
 THIRD HARMONIC BIO INC$36,928,264
+32.8%
5,779,0710.0%0.78%
+55.6%
UNH SellUNITEDHEALTH GROUP INC$35,293,300
-69.9%
70,000
-71.3%
0.75%
-64.7%
SBTX BuyARS PHARMACEUTICALS INC$34,930,553
-40.4%
9,240,887
+5.7%
0.74%
-30.1%
AMGN  AMGEN INC$34,213,148
+21.1%
127,3000.0%0.73%
+42.0%
PRLD  PRELUDE THERAPEUTICS INC$33,709,601
-31.3%
10,909,2560.0%0.72%
-19.6%
JANX BuyJANUX THERAPEUTICS INC$33,444,704
-0.7%
3,317,927
+17.0%
0.71%
+16.4%
XENE SellXENON PHARMACEUTICALS INC$32,752,369
-22.4%
958,793
-12.5%
0.70%
-9.0%
ICLR NewICON PLC$32,554,250132,200
+100.0%
0.69%
HZNP SellHORIZON THERAPEUTICS PUB L$30,819,816
-5.3%
266,400
-15.8%
0.66%
+11.0%
NewAPOGEE THERAPEUTICS INC$30,414,2911,427,901
+100.0%
0.65%
GRCL BuyGRACELL BIOTECHNOLOGIES INCsponsored ads$26,809,131
-22.1%
9,308,726
+3.0%
0.57%
-8.8%
TELA  TELA BIO INC$22,684,336
-21.0%
2,835,5420.0%0.48%
-7.3%
IOVA  IOVANCE BIOTHERAPEUTICS INC$21,418,934
-35.4%
4,707,4580.0%0.46%
-24.2%
NewNEUMORA THERAPEUTICS INC.$21,165,0001,500,000
+100.0%
0.45%
VERA SellVERA THERAPEUTICS INCcl a$20,813,357
-26.2%
1,518,115
-13.6%
0.44%
-13.5%
RAPT SellRAPT THERAPEUTICS INC$20,690,986
-11.6%
1,244,945
-0.5%
0.44%
+3.8%
ABCL  ABCELLERA BIOLOGICS INC$19,231,533
-28.8%
4,180,7680.0%0.41%
-16.4%
SNDX SellSYNDAX PHARMACEUTICALS INC$18,643,680
-64.8%
1,284,000
-49.3%
0.40%
-58.8%
AKRO BuyAKERO THERAPEUTICS INC$17,703,000
+90.1%
350,000
+75.4%
0.38%
+122.5%
AZN NewASTRAZENECA PLCcall$16,930,000250,000
+100.0%
0.36%
ARGX  ARGENX SEsponsored adr$16,027,138
+26.1%
32,6000.0%0.34%
+47.8%
SRRK BuySCHOLAR ROCK HLDG CORP$14,439,902
+160.3%
2,033,789
+176.5%
0.31%
+204.0%
QURE  UNIQURE NV$13,852,493
-41.4%
2,064,4550.0%0.29%
-31.5%
IKNA  IKENA ONCOLOGY INC$13,796,099
-34.0%
3,186,1660.0%0.29%
-22.7%
ALXO  ALX ONCOLOGY HLDGS INC$13,780,800
-36.1%
2,871,0000.0%0.29%
-25.1%
RYTM NewRHYTHM PHARMACEUTICALS INC$13,379,993583,642
+100.0%
0.28%
 VERASTEM INC$12,431,705
+9.3%
1,529,1150.0%0.26%
+28.2%
NewTURNSTONE BIOLOGICS CORP$12,211,1043,099,265
+100.0%
0.26%
IMTX BuyIMMATICS N.V$12,161,316
+9.0%
1,050,200
+8.6%
0.26%
+27.7%
SellVENTYX BIOSCIENCES INC$11,821,536
-33.4%
340,384
-37.1%
0.25%
-22.0%
ARWR BuyARROWHEAD PHARMACEUTICALS IN$11,652,202
+179.3%
433,651
+270.6%
0.25%
+226.3%
ACET  ADICET BIO INC$11,401,332
-43.6%
8,322,1400.0%0.24%
-33.9%
KNTE  KINNATE BIOPHARMA INC$11,213,621
-53.8%
8,009,7290.0%0.24%
-45.9%
REGN  REGENERON PHARMACEUTICALS$11,109,960
+14.5%
13,5000.0%0.24%
+34.1%
SGEN NewSEAGEN INCcall$10,607,50050,000
+100.0%
0.22%
AVTE  AEROVATE THERAPEUTICS INC$10,271,540
-20.9%
756,9300.0%0.22%
-7.2%
ARQT  ARCUTIS BIOTHERAPEUTICS INC$10,165,883
-44.3%
1,914,4790.0%0.22%
-34.7%
CRVS  CORVUS PHARMACEUTICALS INC$10,137,735
-36.2%
6,943,6540.0%0.22%
-25.3%
SGEN NewSEAGEN INC$9,037,59042,600
+100.0%
0.19%
GDRX SellGOODRX HLDGS INC$8,979,850
-9.0%
1,595,000
-10.8%
0.19%
+6.7%
 INVIVYD INC$8,959,680
+61.9%
5,270,4000.0%0.19%
+90.0%
FUSN  FUSION PHARMACEUTICALS INC$8,119,202
-44.3%
3,122,7700.0%0.17%
-34.8%
XFOR  X4 PHARMACEUTICALS INC$7,775,531
-43.8%
7,133,5150.0%0.16%
-34.3%
GILD  GILEAD SCIENCES INC$7,494,000
-2.8%
100,0000.0%0.16%
+13.6%
PASG  PASSAGE BIO INC$6,661,971
-30.1%
10,124,5760.0%0.14%
-17.9%
 MOONLAKE IMMUNOTHERAPEUTICSclass a ord$6,669,000
+11.8%
117,0000.0%0.14%
+31.5%
KZR  KEZAR LIFE SCIENCES INC$6,500,970
-51.4%
5,463,0000.0%0.14%
-43.2%
NewKENVUE INC$6,273,072312,404
+100.0%
0.13%
NSPR  INSPIREMD INC$6,083,524
+30.3%
1,860,4050.0%0.13%
+51.8%
ORIC SellORIC PHARMACEUTICALS INC$5,406,691
-40.4%
893,668
-23.5%
0.12%
-29.9%
NewKENVUE INCcall$5,020,000250,000
+100.0%
0.11%
CGEM  CULLINAN ONCOLOGY INC$4,930,874
-15.9%
544,8480.0%0.10%
-0.9%
MORF  MORPHIC HLDG INC$4,776,735
-60.0%
208,5000.0%0.10%
-53.5%
DXCM NewDEXCOM INCcall$4,665,00050,000
+100.0%
0.10%
MRTX NewMIRATI THERAPEUTICS INCcall$4,356,000100,000
+100.0%
0.09%
RLAY NewRELAY THERAPEUTICS INC$4,221,534501,966
+100.0%
0.09%
CUTR BuyCUTERA INC$3,630,662
-38.0%
603,100
+55.8%
0.08%
-27.4%
BuyYS BIOPHARMA CO LTDordinary shares$3,633,138
-38.8%
4,541,422
+5.7%
0.08%
-28.0%
NXTC  NEXTCURE INC$3,497,207
-28.3%
2,711,0130.0%0.07%
-15.9%
APLS NewAPELLIS PHARMACEUTICALS INCcall$2,948,10077,500
+100.0%
0.06%
EPIX SellESSA PHARMA INC$2,602,911
+4.6%
842,366
-8.6%
0.06%
+22.2%
 VIGIL NEUROSCIENCE INC$2,419,522
-42.7%
448,8910.0%0.05%
-32.9%
KRTX NewKARUNA THERAPEUTICS INC$2,367,26014,000
+100.0%
0.05%
CMMB  CHEMOMAB THERAPEUTICS LTDsponsored ads$2,005,940
-31.9%
2,241,2740.0%0.04%
-18.9%
TDOC NewTELADOC HEALTH INC$2,044,900110,000
+100.0%
0.04%
AFIB  ACUTUS MED INC$1,844,866
-21.6%
2,648,3860.0%0.04%
-9.3%
BCAB SellBIOATLA INC$1,715,774
-50.5%
1,009,279
-12.7%
0.04%
-42.9%
PHGE  BIOMX INC$1,602,828
-2.2%
4,553,4890.0%0.03%
+13.3%
BOLT  BOLT BIOTHERAPEUTICS INC$1,602,640
-18.8%
1,541,0000.0%0.03%
-5.6%
IMTX NewIMMATICS N.Vcall$1,447,500125,000
+100.0%
0.03%
TARA  PROTARA THERAPEUTICS INC$1,290,215
-30.1%
772,5840.0%0.03%
-18.2%
NewSYNLOGIC INC$1,129,614401,998
+100.0%
0.02%
ELEV  ELEVATION ONCOLOGY INC$993,900
-56.4%
1,500,0000.0%0.02%
-48.8%
HRTX  HERON THERAPEUTICS INC$826,781
-11.2%
802,7000.0%0.02%
+5.9%
 CALCIMEDICA INC$790,882
-33.7%
297,3800.0%0.02%
-22.7%
GLTO SellGALECTO INC$665,385
-93.1%
924,788
-75.9%
0.01%
-92.0%
XNCR NewXENCOR INC$385,71119,142
+100.0%
0.01%
ALT  ALTIMMUNE INC$260,000
-26.3%
100,0000.0%0.01%0.0%
NewHARPOON THERAPEUTICS INC$250,34862,121
+100.0%
0.01%
OMIC  SINGULAR GENOMICS SYSTEMS IN$206,006
-54.1%
540,6970.0%0.00%
-50.0%
NKTR ExitNEKTAR THERAPEUTICScall$0-515,000
-100.0%
-0.01%
HARP ExitHARPOON THERAPEUTICS INC$0-621,218
-100.0%
-0.01%
MRSN ExitMERSANA THERAPEUTICS INCcall$0-250,000
-100.0%
-0.02%
TGTX ExitTG THERAPEUTICS INCcall$0-45,800
-100.0%
-0.02%
RVNC ExitREVANCE THERAPEUTICS INC$0-100,000
-100.0%
-0.05%
SYBX ExitSYNLOGIC INC$0-6,029,995
-100.0%
-0.05%
ALKS ExitALKERMES PLC$0-151,400
-100.0%
-0.09%
HZNP ExitHORIZON THERAPEUTICS PUB Lput$0-50,000
-100.0%
-0.09%
THC ExitTENET HEALTHCARE CORPcall$0-100,000
-100.0%
-0.15%
GHRS ExitGH RESEARCH PLCordinary shares$0-736,315
-100.0%
-0.16%
ExitBRIDGEBIO PHARMA INCnote 2.250% 2/0$0-15,000,000
-100.0%
-0.17%
HUM ExitHUMANA INCcall$0-25,000
-100.0%
-0.20%
BAX ExitBAXTER INTL INCcall$0-300,000
-100.0%
-0.25%
DBTX ExitDECIBEL THERAPEUTICS INC$0-4,945,192
-100.0%
-0.34%
FOLD ExitAMICUS THERAPEUTICS INC$0-1,856,400
-100.0%
-0.42%
MRSN ExitMERSANA THERAPEUTICS INC$0-7,214,937
-100.0%
-0.43%
Exit2SEVENTY BIO INC$0-2,391,628
-100.0%
-0.44%
TVTX ExitTRAVERE THERAPEUTICS INC$0-2,118,100
-100.0%
-0.59%
ZBH ExitZIMMER BIOMET HOLDINGS INC$0-245,000
-100.0%
-0.65%
EW ExitEDWARDS LIFESCIENCES CORP$0-515,000
-100.0%
-0.88%
VECT ExitVECTIVBIO HLDG AG$0-5,156,561
-100.0%
-1.59%
BMY ExitBRISTOL-MYERS SQUIBB CO$0-1,488,000
-100.0%
-1.72%
Other managers

Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):

Original filings

The following EDGAR filing(s) were analyzed to create this report:

  • View 13F-HR filed 2023-11-14
Signatures

The EDGAR filing(s) were signed by:

About Orbimed Advisors

Orbimed Advisors is a leading healthcare-focused investment firm that manages over $16 billion in assets. The firm was founded in 1998 by Samuel Isaly, who has over 50 years of experience in the healthcare industry. Isaly is widely regarded as a pioneer in the field of healthcare investing and has been recognized for his contributions to the industry by numerous organizations.

Orbimed Advisors has a team of over 100 professionals, including investment professionals, research analysts, and operational experts. The firm has offices in New York, San Francisco, Shanghai, and Mumbai, and invests in companies across the healthcare spectrum, including biotechnology, pharmaceuticals, medical devices, and healthcare services.

The firm's investment philosophy is based on a deep understanding of the healthcare industry and a rigorous approach to due diligence. Orbimed Advisors seeks to identify companies with innovative technologies and strong management teams that have the potential to transform the healthcare landscape.

Orbimed Advisors has a strong track record of success, with numerous successful investments in companies such as Juno Therapeutics, Spark Therapeutics, and Kite Pharma. The firm's leadership team, which includes CEO Sven Borho, COO Jonathan Silverstein, and Chief Investment Officer Carl Gordon, has decades of experience in the healthcare industry and is widely respected for their expertise and insights.

Overall, Orbimed Advisors is a leading healthcare investment firm that has a proven track record of success and a deep understanding of the healthcare industry. Investors looking to gain exposure to the healthcare sector may want to consider Orbimed Advisors as a potential investment opportunity.

It's important to note that this information is for educational purposes only and has not been fact-checked. As with any investment, it's important to do your own research and consult with a financial advisor before making any investment decisions.

Top long-term holdings
NameQuarters ownedLatest quarter ownedMax weighting
BIOGEN INC42Q3 20235.0%
VERTEX PHARMACEUTICALS INC42Q3 20233.7%
THERMO FISHER SCIENTIFIC INC42Q3 20233.2%
SINOVAC BIOTECH LTD41Q3 20237.2%
NEUROCRINE BIOSCIENCES INC41Q3 20232.7%
BOSTON SCIENTIFIC CORP40Q3 20235.6%
BRISTOL-MYERS SQUIBB CO40Q2 20235.2%
AMGEN INC40Q3 20235.5%
INTUITIVE SURGICAL INC40Q3 20233.8%
GILEAD SCIENCES INC39Q3 20235.5%

View Orbimed Advisors's complete holdings history.

Latest significant ownerships (13-D/G)
Orbimed Advisors Q3 2023 significant holdings filed using form 13D/G when ownership exceeds 5% of a company's total stock issue.
FiledShares Percentage
Ikena Oncology, Inc.September 21, 20232,189,1115.2%
Galecto, Inc.September 18, 2023749,5572.8%
PMV Pharmaceuticals, Inc.August 23, 20236,563,07713.5%
Gracell Biotechnologies Inc.August 11, 20237,641,5318.0%
Xtant Medical Holdings, Inc.August 03, 202373,114,59256.7%
Turnstone Biologics Corp.July 24, 20233,099,26513.4%
Passage BIO, Inc.June 29, 20238,034,00014.7%
Prelude Therapeutics IncMay 24, 202315,716,64228.6%
VectivBio Holding AGMay 24, 20235,156,5617.7%
Fusion Pharmaceuticals Inc.May 16, 20232,930,6704.6%

View Orbimed Advisors's complete significant-ownership history.

Latest filings
TypeFiled
3/A2024-04-12
SC 13D/A2024-04-12
42024-04-05
SC 13D/A2024-04-04
32024-04-03
SC 13D2024-03-28
32024-03-27
SC 13D/A2024-03-22
SC 13D/A2024-03-21
SC 13D/A2024-03-08

View Orbimed Advisors's complete filings history.

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