| Soleus Capital Management, L.P. | 1,907,823 | $25,011,560 | 2.31% |
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| FORMULA GROWTH LTD | 222,269 | $2,913,947 | 0.99% |
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| EMERALD MUTUAL FUND ADVISERS TRUST | 1,193,939 | $15,652,540 | 0.94% |
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| EMERALD ADVISERS, LLC | 1,473,281 | $19,314,713 | 0.94% |
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| Perceptive Advisors | 1,834,060 | $24,044,527 | 0.80% |
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| NEXT CENTURY GROWTH INVESTORS LLC | 512,738 | $6,721,995 | 0.73% |
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| OBERWEIS ASSET MANAGEMENT INC/ | 355,600 | $4,661,916 | 0.50% |
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| Novo Holdings A/S | 360,000 | $4,719,600 | 0.35% |
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| TimesSquare Capital Management, LLC | 1,433,429 | $18,792 | 0.29% |
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| KORNITZER CAPITAL MANAGEMENT INC /KS | 677,733 | $8,885,080 | 0.18% |
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| OAK RIDGE INVESTMENTS LLC | 88,665 | $1,162,398 | 0.15% |
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| DRIEHAUS CAPITAL MANAGEMENT LLC | 570,582 | $7,480,330 | 0.10% |
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| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,786,001 | $23,414,473 | 0.08% |
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| Numerai GP LLC | 16,564 | $217,154 | 0.07% |
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| Polar Asset Management Partners Inc. | 222,671 | $2,919,217 | 0.06% |
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| UBS OCONNOR LLC | 173,004 | $2,268,082 | 0.06% |
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| Point72 Asset Management, L.P. | 1,252,628 | $16,421,953 | 0.05% |
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| FWL INVESTMENT MANAGEMENT, LLC | 5,347 | $70,099 | 0.05% |
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| Spouting Rock Asset Management, LLC | 11,260 | $147,619 | 0.05% |
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| CIBC Private Wealth Group, LLC | 1,384,051 | $18,144,909 | 0.04% |
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