| Type | Filed | Filer | Subject | Shares Owned | Percent Owned | |
|---|---|---|---|---|---|---|
| SC 13G/A | 2019-02-12 | MORGAN STANLEY | Tekla Healthcare Opportunities Fund | 1,885,658 | 4.4% | EDGAR |
| SC 13G/A | 2018-02-13 | MORGAN STANLEY | Tekla Healthcare Opportunities Fund | 2,964,227 | 6.8% | EDGAR |
| SC 13G/A | 2017-02-13 | MORGAN STANLEY | Tekla Healthcare Opportunities Fund | 2,905,189 | 6.6% | EDGAR |
| SC 13G | 2016-02-11 | MORGAN STANLEY | Tekla Healthcare Opportunities Fund | 2,795,332 | 6.4% | EDGAR |