| Essex Woodlands Management, Inc. | 4,110,709 | $32,885,672 | 28.99% |
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| Velan Capital Investment Management LP | 746,087 | $5,968,696 | 4.81% |
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| AIGH Capital Management LLC | 1,252,945 | $10,023,560 | 4.74% |
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| Opaleye Management Inc. | 750,000 | $6,000,000 | 1.95% |
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| First Light Asset Management, LLC | 2,480,264 | $19,842,112 | 1.88% |
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| JACOB ASSET MANAGEMENT OF NEW YORK LLC | 159,775 | $1,278,200 | 1.80% |
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| PERKINS CAPITAL MANAGEMENT INC | 190,500 | $1,524 | 1.51% |
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| Worth Venture Partners, LLC | 314,220 | $2,513,760 | 1.49% |
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| Stonepine Capital Management, LLC | 491,919 | $3,935,352 | 1.31% |
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| SILVERARC CAPITAL MANAGEMENT, LLC | 490,471 | $3,923,768 | 1.19% |
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| SECTORAL ASSET MANAGEMENT INC | 525,000 | $4,200,000 | 0.82% |
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| Kamunting Street Capital Management, L.P. | 95,694 | $765,552 | 0.58% |
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| PURA VIDA INVESTMENTS, LLC | 337,175 | $2,697,400 | 0.51% |
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| Orbimed Advisors | 2,835,542 | $22,684,336 | 0.48% |
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| NEXT CENTURY GROWTH INVESTORS LLC | 473,131 | $3,785,048 | 0.41% |
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| Nantahala Capital Management | 456,092 | $3,648,736 | 0.31% |
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| Parkman Healthcare Partners LLC | 166,725 | $1,333,800 | 0.24% |
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| SANDERS MORRIS HARRIS LLC | 68,168 | $545,344 | 0.11% |
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| PARADIGM CAPITAL MANAGEMENT INC/NY | 219,500 | $1,756,000 | 0.10% |
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| KENNEDY CAPITAL MANAGEMENT LLC | 387,623 | $3,100,984 | 0.08% |
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