| Type | Filed | Filer | Subject | Shares Owned | Percent Owned | |
|---|---|---|---|---|---|---|
| SC 13G/A | 2024-04-25 | Rosalind Advisors, Inc. | SPRUCE BIOSCIENCES, INC. | 1,508,419 | 3.7% | EDGAR |
| SC 13D/A | 2024-03-28 | Novo Holdings A/S | SPRUCE BIOSCIENCES, INC. | 1,656,000 | 3.9% | EDGAR |
| SC 13G | 2024-03-28 | Radoff Bradley Louis | SPRUCE BIOSCIENCES, INC. | 2,825,000 | 6.9% | EDGAR |
| SC 13D/A | 2024-03-25 | Novo Holdings A/S | SPRUCE BIOSCIENCES, INC. | 2,756,000 | 6.4% | EDGAR |
| SC 13D/A | 2024-03-20 | Novo Holdings A/S | SPRUCE BIOSCIENCES, INC. | 4,671,021 | 10.9% | EDGAR |
| SC 13D/A | 2024-03-18 | Novo Holdings A/S | SPRUCE BIOSCIENCES, INC. | 6,466,020 | 15.1% | EDGAR |
| SC 13D/A | 2024-03-07 | HealthCap VIII, L.P. | SPRUCE BIOSCIENCES, INC. | 3,685,621 | 8.9% | EDGAR |
| SC 13G/A | 2024-02-14 | CITADEL ADVISORS LLC | SPRUCE BIOSCIENCES, INC. | - | 0.2% | EDGAR |
| SC 13G/A | 2024-02-14 | Rock Springs Capital Management LP | SPRUCE BIOSCIENCES, INC. | 2,609,125 | 6.4% | EDGAR |
| SC 13G | 2024-02-14 | ARMISTICE CAPITAL, LLC | SPRUCE BIOSCIENCES, INC. | 2,230,000 | 5.5% | EDGAR |
| SC 13G/A | 2024-02-06 | Aisling Capital V, LP | SPRUCE BIOSCIENCES, INC. | 1,205,511 | 3.0% | EDGAR |
| SC 13G | 2024-01-30 | Rosalind Advisors, Inc. | SPRUCE BIOSCIENCES, INC. | 2,322,000 | 5.7% | EDGAR |
| SC 13D/A | 2023-05-30 | RiverVest Venture Fund III, L.P. | SPRUCE BIOSCIENCES, INC. | 1,641,077 | 4.0% | EDGAR |
| SC 13G | 2023-02-27 | 5AM Opportunities II, L.P. | SPRUCE BIOSCIENCES, INC. | 4,137,000 | 10.0% | EDGAR |
| SC 13D/A | 2023-02-23 | Carlyle Group Inc. | SPRUCE BIOSCIENCES, INC. | 3,734,518 | 9.2% | EDGAR |
| SC 13D/A | 2023-02-21 | Novo Holdings A/S | SPRUCE BIOSCIENCES, INC. | 8,378,336 | 19.9% | EDGAR |
| SC 13G/A | 2023-02-14 | CITADEL ADVISORS LLC | SPRUCE BIOSCIENCES, INC. | - | 7.2% | EDGAR |
| SC 13G/A | 2023-02-14 | Rock Springs Capital Management LP | SPRUCE BIOSCIENCES, INC. | 1,622,689 | 6.9% | EDGAR |
| SC 13D/A | 2023-02-13 | HealthCap VIII, L.P. | SPRUCE BIOSCIENCES, INC. | 3,685,621 | 8.9% | EDGAR |
| SC 13D/A | 2022-09-30 | Novo Holdings A/S | SPRUCE BIOSCIENCES, INC. | 4,514,336 | 19.2% | EDGAR |