| RiverVest Venture Management LLC | 2,936,281 | $6,635,996 | 16.41% |
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| Omega Fund Management, LLC | 2,161,022 | $4,883,910 | 4.49% |
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| 5AM Venture Management, LLC | 2,364,000 | $5,342,640 | 1.54% |
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| AIGH Capital Management LLC | 1,211,000 | $2,736,860 | 1.30% |
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| Novo Holdings A/S | 6,722,336 | $15,192,479 | 1.12% |
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| Aisling Capital Management LP | 1,205,511 | $2,724,455 | 1.12% |
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| Sands Capital Ventures, LLC | 787,007 | $1,778,636 | 0.53% |
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| Worth Venture Partners, LLC | 302,074 | $682,687 | 0.40% |
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| DAFNA Capital Management LLC | 570,130 | $1,288,494 | 0.40% |
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| Acuitas Investments, LLC | 275,001 | $621,502 | 0.36% |
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| Carlyle Group Inc. | 2,896,518 | $6,459,235 | 0.28% |
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| Rock Springs Capital Management LP | 2,728,125 | $6,165,563 | 0.16% |
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| ARMISTICE CAPITAL, LLC | 3,056,000 | $6,906,560 | 0.11% |
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| Privium Fund Management (UK) Ltd | 24,554 | $54,755 | 0.04% |
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| Verition Fund Management LLC | 1,319,393 | $2,981,828 | 0.04% |
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| Marquette Asset Management, LLC | 55,757 | $126,011 | 0.03% |
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| Alyeska Investment Group, L.P. | 1,000,000 | $2,260,000 | 0.02% |
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| Sofinnova Investments, Inc. | 58,029 | $131,146 | 0.01% |
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| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 85,000 | $192,100 | 0.01% |
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| CALDWELL SUTTER CAPITAL, INC. | 1,000 | $2,260 | 0.00% |
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