| Connective Portfolio Management, LLC | 4,000 | $485,000 | 1.48% |
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| TOBAM | 148,941 | $18,055 | 1.45% |
|---|
| PFM Health Sciences, LP | 250,967 | $30,422,220 | 1.43% |
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| Orbimed Advisors | 529,200 | $64,149,624 | 1.36% |
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| Rock Springs Capital Management LP | 392,000 | $47,518,240 | 1.27% |
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| ACUTA CAPITAL PARTNERS, LLC | 15,500 | $1,878,910 | 1.26% |
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| Caption Management, LLC | 656,100 | $79,532,442 | 1.22% |
|---|
| SPHERA FUNDS MANAGEMENT LTD. | 50,000 | $6,061,000 | 1.10% |
|---|
| Diametric Capital, LP | 21,657 | $2,625,261 | 1.10% |
|---|
| INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 26,700 | $3,234,972 | 1.09% |
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| Palo Alto Investors LP | 94,030 | $11,398,317 | 1.08% |
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| MIZUHO MARKETS AMERICAS LLC | 245,939 | $29,812,726 | 1.04% |
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| Atlantic Private Wealth, LLC | 7,500 | $909,150 | 0.92% |
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| FARALLON CAPITAL MANAGEMENT LLC | 1,375,200 | $166,701,744 | 0.84% |
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| Caption Management, LLC | 396,500 | $48,063,730 | 0.74% |
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| Perceptive Advisors | 182,720 | $22,149,318 | 0.74% |
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| WESTFIELD CAPITAL MANAGEMENT CO LP | 806,400 | $97,751,772 | 0.67% |
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| EFG Asset Management (North America) Corp. | 22,712 | $2,753,262 | 0.65% |
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| BOOTHBAY FUND MANAGEMENT, LLC | 224,600 | $27,226,012 | 0.65% |
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| Worth Venture Partners, LLC | 7,300 | $884,906 | 0.52% |
|---|