| Camber Capital Management LP | 7,000,000 | $339,010 | 11.63% |
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| Eversept Partners, LP | 1,603,348 | $77,650,144 | 6.80% |
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| SPHERA FUNDS MANAGEMENT LTD. | 559,515 | $27,097,311 | 5.82% |
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| Virtus Family Office LLC | 52,623 | $2,548,532 | 5.69% |
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| Sofinnova Investments, Inc. | 1,965,475 | $95,187,954 | 5.65% |
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| Iron Triangle Partners LP | 650,000 | $31,479,500 | 5.64% |
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| Callodine Capital Management, LP | 350,000 | $16,950,500 | 5.05% |
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| NKCFO LLC | 214,575 | $10,392 | 4.87% |
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| MANAGED ASSET PORTFOLIOS, LLC | 626,080 | $30,321 | 4.74% |
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| OAK FAMILY ADVISORS, LLC | 182,383 | $8,832,809 | 4.73% |
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| Redwood Grove Capital, LLC | 146,544 | $7,097,126 | 3.52% |
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| Y.D. More Investments Ltd | 287,108 | $13,939,093 | 3.38% |
|---|
| EQUITY INVESTMENT CORP | 1,927,433 | $93,345,580 | 3.14% |
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| DODGE & COX | 84,189,074 | $4,077,276,854 | 2.80% |
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| INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 143,500 | $6,942,530 | 2.14% |
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| FOUNDATION RESOURCE MANAGEMENT INC | 257,709 | $12,481 | 2.06% |
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| Integral Health Asset Management, LLC | 200,000 | $9,686,000 | 2.03% |
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| Altrius Capital Management Inc | 131,827 | $6,384,399 | 2.00% |
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| Eagle Ridge Investment Management | 348,810 | $16,892,868 | 1.97% |
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| MUFG Securities EMEA plc | 1,000,000 | $96,275 | 1.59% |
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