| Palo Alto Investors LP | 5,228,609 | $132,336,094 | 10.69% |
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| Essex Woodlands Management, Inc. | 457,085 | $11,568,821 | 8.76% |
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| Ghost Tree Capital, LLC | 525,000 | $13,287,750 | 4.39% |
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| INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 288,726 | $7,298,993 | 2.22% |
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| Evolutionary Tree Capital Management, LLC | 59,411 | $1,503,692 | 1.81% |
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| Sio Capital Management, LLC | 141,500 | $3,581,365 | 0.91% |
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| RICE HALL JAMES & ASSOCIATES, LLC | 552,495 | $13,983,655 | 0.79% |
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| Integral Health Asset Management, LLC | 250,000 | $6,327,500 | 0.78% |
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| Waypoint Capital Advisors, LLC | 90,989 | $2,302,932 | 0.72% |
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| Polar Capital Holdings Plc | 4,167,842 | $105,488,081 | 0.53% |
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| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 870,000 | $22,019,700 | 0.47% |
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| RF&L WEALTH MANAGEMENT, LLC | 20,000 | $506,200 | 0.46% |
|---|
| ESSEX INVESTMENT MANAGEMENT CO LLC | 108,860 | $2,755,247 | 0.38% |
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| Rhenman & Partners Asset Management AB | 123,000 | $3,113,130 | 0.33% |
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| Neo Ivy Capital Management | 23,952 | $606 | 0.32% |
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| Jackson Creek Investment Advisors LLC | 29,839 | $755 | 0.30% |
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| SEVEN EIGHT CAPITAL, LP | 70,697 | $1,789,341 | 0.30% |
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| Caption Management, LLC | 569,800 | $14,421,638 | 0.26% |
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| Granahan Investment Management | 288,927 | $7,312,742 | 0.22% |
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| Nebula Research & Development LLC | 11,619 | $294,077 | 0.22% |
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